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Conserved domains on  [gi|568955498|ref|XP_006509753|]
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anoctamin-8 isoform X6 [Mus musculus]

Protein Classification

anoctamin family protein( domain architecture ID 10518511)

anoctamin family protein similar to anoctamin (anion channel with 8 transmembrane domains), which is a calcium-activated protein and may mediate the calcium-dependent exposure of phospholipids to the extracellular surface, a process called phospholipid scrambling

Gene Ontology:  GO:0005509|GO:0005254|GO:1902476
PubMed:  24692353|21607626|23532839|28724583|19015192
SCOP:  4004881
TCDB:  1.A.17

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
 237-470 3.96e-81

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


:

Pssm-ID: 461349  Cd Length: 377  Bit Score: 269.45  E-value: 3.96e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498   237 ICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEAdqTSRDVSCVVFALFNVIWSTLFLEEWKRRGAELAYKWGTL 316
Cdd:pfam04547    1 IRDYFGEKIAFYFAFLGFYTKWLLPPAIVGLLVFLYGLA--TLFDPYTVFFAIFMSLWATLFLEFWKRREAELAYRWGTT 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498   317 DSpgEAVEEPRPQFRGI-RRISPITRAEEFYYPPWKRLLFQLLVSLPLC--LACLICVFILMlgcfqlqelvlsvkglpr 393
Cdd:pfam04547   79 GF--EEEEEPRPEFKGEkERINPVTGEKEPYYPPWKRRLRRYLLSIPLVllLIALLVLGVII------------------ 138

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498   394 lvrFLPKVmlallvsvsaegYKKLAVWLNDMENYRLESTYERHLIIKVVLM-----LATLLITRQLLQNVREVLQPHLYR 468
Cdd:pfam04547  139 ---YLNFV------------YTKLAKKLTDWENHRTQSEYENSLILKVFLDrlriqLAIIMVTKQIINNITEVVLPYLKR 203


                   ..
gi 568955498   469 RL 470
Cdd:pfam04547  204 KR 205
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
 678-847 5.41e-69

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


:

Pssm-ID: 461349  Cd Length: 377  Bit Score: 235.94  E-value: 5.41e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498   678 RQKRHNRSSWIDPPEEEHSPQLTQAELESCMKKYEDtFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKL 757
Cdd:pfam04547  211 KKKKKEEPSVSIKDEPEESEFLERVEKEYELEPYDG-LDDYLEMVIQFGYVTLFSAAFPLAPLFALLNNIIEIRSDAFKL 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498   758 CTGLQRPFGRRVESIGQWQKVMEAMGVLAIVVNCYLIGQCGQLQRLFPWlspeAAIVS-VVVLEHLALLVKYLIHVAIPD 836
Cdd:pfam04547  290 CTELRRPVPERADSIGPWLNILEFLSWLAVITNAALIYAFTSDQYWSLL----ALLLAfVIVFEHVVLLLKFLIAWLIPD 365

                          170
                   ....*....|.
gi 568955498   837 IPGWVAEEMAK 847
Cdd:pfam04547  366 VPEWVRKERKR 376
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
895-1074 3.49e-08

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK12323:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 700  Bit Score: 57.58  E-value: 3.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  895 GGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVlrlkqiiplQTRPPAPTGCAPPPRSPADTRLPAFLSLR 974
Cdd:PRK12323  370 GGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPA---------AAAAARAVAAAPARRSPAPEALAAARQAS 440

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  975 FLKAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAePEPRPEDagsasPPagcwrwdaPWgcGDNPP 1054
Cdd:PRK12323  441 ARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAA-PAPADDD-----PP--------PW--EELPP 504

                         170       180
                  ....*....|....*....|
gi 568955498 1055 RVPADVPADAPAQPACWPTA 1074
Cdd:PRK12323  505 EFASPAPAQPDAAPAGWVAE 524
 
Name Accession Description Interval E-value
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
 237-470 3.96e-81

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


Pssm-ID: 461349  Cd Length: 377  Bit Score: 269.45  E-value: 3.96e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498   237 ICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEAdqTSRDVSCVVFALFNVIWSTLFLEEWKRRGAELAYKWGTL 316
Cdd:pfam04547    1 IRDYFGEKIAFYFAFLGFYTKWLLPPAIVGLLVFLYGLA--TLFDPYTVFFAIFMSLWATLFLEFWKRREAELAYRWGTT 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498   317 DSpgEAVEEPRPQFRGI-RRISPITRAEEFYYPPWKRLLFQLLVSLPLC--LACLICVFILMlgcfqlqelvlsvkglpr 393
Cdd:pfam04547   79 GF--EEEEEPRPEFKGEkERINPVTGEKEPYYPPWKRRLRRYLLSIPLVllLIALLVLGVII------------------ 138

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498   394 lvrFLPKVmlallvsvsaegYKKLAVWLNDMENYRLESTYERHLIIKVVLM-----LATLLITRQLLQNVREVLQPHLYR 468
Cdd:pfam04547  139 ---YLNFV------------YTKLAKKLTDWENHRTQSEYENSLILKVFLDrlriqLAIIMVTKQIINNITEVVLPYLKR 203


                   ..
gi 568955498   469 RL 470
Cdd:pfam04547  204 KR 205
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
 678-847 5.41e-69

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


Pssm-ID: 461349  Cd Length: 377  Bit Score: 235.94  E-value: 5.41e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498   678 RQKRHNRSSWIDPPEEEHSPQLTQAELESCMKKYEDtFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKL 757
Cdd:pfam04547  211 KKKKKEEPSVSIKDEPEESEFLERVEKEYELEPYDG-LDDYLEMVIQFGYVTLFSAAFPLAPLFALLNNIIEIRSDAFKL 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498   758 CTGLQRPFGRRVESIGQWQKVMEAMGVLAIVVNCYLIGQCGQLQRLFPWlspeAAIVS-VVVLEHLALLVKYLIHVAIPD 836
Cdd:pfam04547  290 CTELRRPVPERADSIGPWLNILEFLSWLAVITNAALIYAFTSDQYWSLL----ALLLAfVIVFEHVVLLLKFLIAWLIPD 365

                          170
                   ....*....|.
gi 568955498   837 IPGWVAEEMAK 847
Cdd:pfam04547  366 VPEWVRKERKR 376
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
895-1074 3.49e-08

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 57.58  E-value: 3.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  895 GGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVlrlkqiiplQTRPPAPTGCAPPPRSPADTRLPAFLSLR 974
Cdd:PRK12323  370 GGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPA---------AAAAARAVAAAPARRSPAPEALAAARQAS 440

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  975 FLKAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAePEPRPEDagsasPPagcwrwdaPWgcGDNPP 1054
Cdd:PRK12323  441 ARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAA-PAPADDD-----PP--------PW--EELPP 504

                         170       180
                  ....*....|....*....|
gi 568955498 1055 RVPADVPADAPAQPACWPTA 1074
Cdd:PRK12323  505 EFASPAPAQPDAAPAGWVAE 524
KLF14_N cd21576
N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as ...
 907-1076 1.98e-03

N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as Krueppel-like factor 14 or basic transcription element-binding protein 5/BTEB5) is a protein that in humans is encoded by the KLF14 gene. KLF14 regulates the transcription of various genes, including TGFbetaRII (the type II receptor for TGFbeta). KLF14 is expressed in many tissues, lacks introns, and is subject to parent-specific expression. It also appears to be a master regulator of gene expression in adipose tissue. KLF14 is associated with coronary artery disease, hypercholesterolemia, and type 2 diabetes. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF14 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF14.


Pssm-ID: 409238 [Multi-domain]  Cd Length: 195  Bit Score: 40.57  E-value: 1.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  907 PDPVAERGAAKAKGSERPRRPgALLPPGPvlRLKQIIPLQTRPPAPtgcaPPPRSPADTRLPAFLSLRFLK--APERGPS 984
Cdd:cd21576    29 PDPEGAGGAAGSEVGAAPPES-ALPGPGP--PGPAWVPPLLQVPAP----SPGAGGAAPHLLAASVLADLRggAGEGSRE 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  985 PPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEpAAAEPEPRPEDAGSASPPAGCWRWDAPWGCGDNPPRV-PADVPAD 1063
Cdd:cd21576   102 DSGEAPRASSGSSDPARGSSPTLGSEPAPASGED-AVSGPESSFGAPAIPSAPAAPGAPAVSGEVPGGAPGAgPAPAAGP 180

                         170
                  ....*....|....
gi 568955498 1064 APAQPACWPTA-RH 1076
Cdd:cd21576   181 APRRRPVTPAAkRH 194
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 884-1039 3.49e-03

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 41.20  E-value: 3.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  884 AEQQARRERDTGGREEARAEAPGPDPVAERGAAKAKGSERP-RRPGALLPPGPVLRLKQIIPLQTRPPAPTG-----CAP 957
Cdd:COG5180   208 DEAQEEPPDLTGGADHPRPEAASSPKVDPPSTSEARSRPATvDAQPEMRPPADAKERRRAAIGDTPAAEPPGlpvleAGS 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  958 PPRS---PADTRLPAFLSLRFLKAPERGPSPPRPGKLFAFSAREPSANGAPgggarahrsAGDEPAAAEPEPRPedagSA 1034
Cdd:COG5180   288 EPQSdapEAETARPIDVKGVASAPPATRPVRPPGGARDPGTPRPGQPTERP---------AGVPEAASDAGQPP----SA 354


                  ....*
gi 568955498 1035 SPPAG 1039
Cdd:COG5180   355 YPPAE 359
 
Name Accession Description Interval E-value
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
 237-470 3.96e-81

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


Pssm-ID: 461349  Cd Length: 377  Bit Score: 269.45  E-value: 3.96e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498   237 ICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEAdqTSRDVSCVVFALFNVIWSTLFLEEWKRRGAELAYKWGTL 316
Cdd:pfam04547    1 IRDYFGEKIAFYFAFLGFYTKWLLPPAIVGLLVFLYGLA--TLFDPYTVFFAIFMSLWATLFLEFWKRREAELAYRWGTT 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498   317 DSpgEAVEEPRPQFRGI-RRISPITRAEEFYYPPWKRLLFQLLVSLPLC--LACLICVFILMlgcfqlqelvlsvkglpr 393
Cdd:pfam04547   79 GF--EEEEEPRPEFKGEkERINPVTGEKEPYYPPWKRRLRRYLLSIPLVllLIALLVLGVII------------------ 138

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498   394 lvrFLPKVmlallvsvsaegYKKLAVWLNDMENYRLESTYERHLIIKVVLM-----LATLLITRQLLQNVREVLQPHLYR 468
Cdd:pfam04547  139 ---YLNFV------------YTKLAKKLTDWENHRTQSEYENSLILKVFLDrlriqLAIIMVTKQIINNITEVVLPYLKR 203


                   ..
gi 568955498   469 RL 470
Cdd:pfam04547  204 KR 205
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
 678-847 5.41e-69

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


Pssm-ID: 461349  Cd Length: 377  Bit Score: 235.94  E-value: 5.41e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498   678 RQKRHNRSSWIDPPEEEHSPQLTQAELESCMKKYEDtFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKL 757
Cdd:pfam04547  211 KKKKKEEPSVSIKDEPEESEFLERVEKEYELEPYDG-LDDYLEMVIQFGYVTLFSAAFPLAPLFALLNNIIEIRSDAFKL 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498   758 CTGLQRPFGRRVESIGQWQKVMEAMGVLAIVVNCYLIGQCGQLQRLFPWlspeAAIVS-VVVLEHLALLVKYLIHVAIPD 836
Cdd:pfam04547  290 CTELRRPVPERADSIGPWLNILEFLSWLAVITNAALIYAFTSDQYWSLL----ALLLAfVIVFEHVVLLLKFLIAWLIPD 365

                          170
                   ....*....|.
gi 568955498   837 IPGWVAEEMAK 847
Cdd:pfam04547  366 VPEWVRKERKR 376
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
895-1074 3.49e-08

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 57.58  E-value: 3.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  895 GGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVlrlkqiiplQTRPPAPTGCAPPPRSPADTRLPAFLSLR 974
Cdd:PRK12323  370 GGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPA---------AAAAARAVAAAPARRSPAPEALAAARQAS 440

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  975 FLKAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAePEPRPEDagsasPPagcwrwdaPWgcGDNPP 1054
Cdd:PRK12323  441 ARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAA-PAPADDD-----PP--------PW--EELPP 504

                         170       180
                  ....*....|....*....|
gi 568955498 1055 RVPADVPADAPAQPACWPTA 1074
Cdd:PRK12323  505 EFASPAPAQPDAAPAGWVAE 524
PHA03247 PHA03247
large tegument protein UL36; Provisional
 883-1074 2.48e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.33  E-value: 2.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  883 HAEQQARRERDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVLRLKQIIPlqtrPPAPTGCAPPPRSP 962
Cdd:PHA03247 2642 PPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPP----PPPTPEPAPHALVS 2717

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  963 ADTRLPAFLSLR-FLKAPERGPSPPRPGKLFAF------SAREPSANGAPGGGARAHRSAGDEPAAAEPEPRPEDAGSAS 1035
Cdd:PHA03247 2718 ATPLPPGPAAARqASPALPAAPAPPAVPAGPATpggparPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRES 2797

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 568955498 1036 PPAGcwrWDAPWGCGDNPPRVPADVPADAPAQPACWPTA 1074
Cdd:PHA03247 2798 LPSP---WDPADPPAAVLAPAAALPPAASPAGPLPPPTS 2833
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 977-1074 2.42e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.91  E-value: 2.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  977 KAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGD-EPAAAEPEPRPEDAGSASPPAGCWRWDAPWGCGDNPPR 1055
Cdd:PRK07764  593 GAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAaAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAK 672

                          90
                  ....*....|....*....
gi 568955498 1056 VPADVPADAPAQPACWPTA 1074
Cdd:PRK07764  673 AGGAAPAAPPPAPAPAAPA 691
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 884-1073 2.63e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.53  E-value: 2.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  884 AEQQARRERDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPvlrlkqiiPLQTRPPAPTGCAPPPRSPA 963
Cdd:PRK07764  600 PPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPE--------HHPKHVAVPDASDGGDGWPA 671

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  964 DTRLPAFLSlrflkAPERGPSPPRPGklfafSAREPSANGAPGGGARAHRSAGDEPAAAEP-------EPRPEDAGSASP 1036
Cdd:PRK07764  672 KAGGAAPAA-----PPPAPAPAAPAA-----PAGAAPAQPAPAPAATPPAGQADDPAAQPPqaaqgasAPSPAADDPVPL 741

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 568955498 1037 PAGCWRWDAPWGCGDNPPRVPADVPADAPAQPACWPT 1073
Cdd:PRK07764  742 PPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSP 778
PHA03247 PHA03247
large tegument protein UL36; Provisional
 904-1074 5.00e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.09  E-value: 5.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  904 APGPDPVA----ERGAAKAKGSERPRRPgallPPGPVLRLKQIIPLQTRPPAPTGCAPPPRSPADTrlPAFLSLRFLKAP 979
Cdd:PHA03247 2628 PPSPSPAAnepdPHPPPTVPPPERPRDD----PAPGRVSRPRRARRLGRAAQASSPPQRPRRRAAR--PTVGSLTSLADP 2701

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  980 ERGPSPPRPgklfafsAREPSANGAPGGGARAHRSAGDEPAAAEPEPRPEDAGSASP--PAGCWRWDAPWG-CGDNPPRV 1056
Cdd:PHA03247 2702 PPPPPTPEP-------APHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPggPARPARPPTTAGpPAPAPPAA 2774

                         170
                  ....*....|....*...
gi 568955498 1057 PADVPADAPAQPACWPTA 1074
Cdd:PHA03247 2775 PAAGPPRRLTRPAVASLS 2792
PHA03247 PHA03247
large tegument protein UL36; Provisional
 887-1069 6.27e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 6.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  887 QARRERDTGGREEARAEAPGPDPVAERGAAKAkgSERPRRPGALLPPGPVLRlkqiiPLQTRPPAP-TGCAPPPRSPADT 965
Cdd:PHA03247 2583 TSRARRPDAPPQSARPRAPVDDRGDPRGPAPP--SPLPPDTHAPDPPPPSPS-----PAANEPDPHpPPTVPPPERPRDD 2655

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  966 RLPAFLSLrflkaPERGPSPPRPGKLFAfSAREPSANGAPGGGARAHRSAGDEPAAAEPEPRPEDAGSASP-PAGcwrwd 1044
Cdd:PHA03247 2656 PAPGRVSR-----PRRARRLGRAAQASS-PPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPlPPG----- 2724

                         170       180
                  ....*....|....*....|....*
gi 568955498 1045 APWGCGDNPPRVPADVPADAPAQPA 1069
Cdd:PHA03247 2725 PAAARQASPALPAAPAPPAVPAGPA 2749
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
887-1041 6.70e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 50.26  E-value: 6.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  887 QARRERDTGGREEARAEAPGPDPVAERGAAKAKGSerPRRPGALLPPGPVLRLkqiiPLQTRPPAPTGCAPPPRSPADTR 966
Cdd:PRK12323  434 AAARQASARGPGGAPAPAPAPAAAPAAAARPAAAG--PRPVAAAAAAAPARAA----PAAAPAPADDDPPPWEELPPEFA 507

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568955498  967 LPAFLSLRFLKAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAhRSAGDEPAAAEPEPRPEDAGSASPPAGCW 1041
Cdd:PRK12323  508 SPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPR-AAAATEPVVAPRPPRASASGLPDMFDGDW 581
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
894-1069 7.74e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 50.23  E-value: 7.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  894 TGGREEARAEAPGPDPVAeRGAAKAKGSERPRRPGALLPPGPVLRlkqiiPLQTRPPAPTGCAPPPRSPAD-------TR 966
Cdd:PRK07003  368 PGGGVPARVAGAVPAPGA-RAAAAVGASAVPAVTAVTGAAGAALA-----PKAAAAAAATRAEAPPAAPAPpatadrgDD 441

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  967 LPAFLSLRFLKAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAEPEPR-PEDAGSASPPAGCWRWDA 1045
Cdd:PRK07003  442 AADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAAtPAAVPDARAPAAASREDA 521

                         170       180
                  ....*....|....*....|....
gi 568955498 1046 PwgcgdNPPRVPAdvPADAPAQPA 1069
Cdd:PRK07003  522 P-----AAAAPPA--PEARPPTPA 538
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 894-1069 1.83e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.83  E-value: 1.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  894 TGGREEARAEApGPDPVAERGAAKAKGSERPRRPGALLPPGPVlrlkqiIPLQTRPPAPTGCAPPPRSPADTRLPAFLSL 973
Cdd:PRK07764  578 LGGDWQVEAVV-GPAPGAAGGEGPPAPASSGPPEEAARPAAPA------APAAPAAPAPAGAAAAPAEASAAPAPGVAAP 650

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  974 RFLKAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAEPEPRP------------------EDAGSAS 1035
Cdd:PRK07764  651 EHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPaatppagqaddpaaqppqAAQGASA 730

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 568955498 1036 PPAGCWR--------WDAPWGCGDNPPRVPADVPADAPAQPA 1069
Cdd:PRK07764  731 PSPAADDpvplppepDDPPDPAGAPAQPPPPPAPAPAAAPAA 772
PHA03247 PHA03247
large tegument protein UL36; Provisional
 900-1069 2.09e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 2.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  900 ARAEAPGPDPVAERGAAKAKGSERPRRP----GALLPPGPVLRLKQiiplqTRPPAPTGCAPP-PRSPADTRLPAFLSLR 974
Cdd:PHA03247 2822 ASPAGPLPPPTSAQPTAPPPPPGPPPPSlplgGSVAPGGDVRRRPP-----SRSPAAKPAAPArPPVRRLARPAVSRSTE 2896

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  975 FLKAPERGPSPPRPGKLfAFSAREPSANGAPGGGARAHRSAGDEPAAAEPEPRPEDAGSASPPAgcwrwDAPWGCGDNPP 1054
Cdd:PHA03247 2897 SFALPPDQPERPPQPQA-PPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAV-----PQPWLGALVPG 2970

                         170
                  ....*....|....*...
gi 568955498 1055 RVPA---DVPADAPAQPA 1069
Cdd:PHA03247 2971 RVAVprfRVPQPAPSREA 2988
PHA03247 PHA03247
large tegument protein UL36; Provisional
 900-1073 2.11e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 2.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  900 ARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVLRLKQIIPLQTRPPAPTGCAPPPRSPADTR-------LPAFLS 972
Cdd:PHA03247 2772 PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTApppppgpPPPSLP 2851

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  973 LRFLKAP-----ERGPSPPRPGKLfAFSAREPSANGAPGGGARAHRSAGDEPAAAEPEPRPEDAGSASPPAGCWRWDAPW 1047
Cdd:PHA03247 2852 LGGSVAPggdvrRRPPSRSPAAKP-AAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQ 2930

                         170       180
                  ....*....|....*....|....*.
gi 568955498 1048 GCGDNPPRVPADVPADAPAQPACWPT 1073
Cdd:PHA03247 2931 PPPPPPPRPQPPLAPTTDPAGAGEPS 2956
PHA03378 PHA03378
EBNA-3B; Provisional
 905-1074 2.84e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 48.52  E-value: 2.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  905 PGPD--PVAERGAAKAKGSERPRRPGALLPPGP-VLRLKQIIPLQTRPP--APTgCAPPPRSPADTRLPaflslrflkaP 979
Cdd:PHA03378  649 PTPHqpPQVEITPYKPTWTQIGHIPYQPSPTGAnTMLPIQWAPGTMQPPprAPT-PMRPPAAPPGRAQR----------P 717

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  980 ERGPSPPRPGKLFAFSAREPSanGAPGggaRAHRSAGDEPAAAEPEPRPedaGSASPPAGCWRWDAPWGCGDNPPrVPAD 1059
Cdd:PHA03378  718 AAATGRARPPAAAPGRARPPA--AAPG---RARPPAAAPGRARPPAAAP---GRARPPAAAPGAPTPQPPPQAPP-APQQ 788

                         170
                  ....*....|....*...
gi 568955498 1060 VPADAPA---QPACWPTA 1074
Cdd:PHA03378  789 RPRGAPTpqpPPQAGPTS 806
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 897-1075 4.03e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 47.67  E-value: 4.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  897 REEARAEAPGPDPVAERGAAKAKGSERPRRPGallppgpvlrlkqiiplqtrPPAPTGCAPPPRSPADTRLPAflslrfl 976
Cdd:PRK07764  380 RLERRLGVAGGAGAPAAAAPSAAAAAPAAAPA--------------------PAAAAPAAAAAPAPAAAPQPA------- 432

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  977 KAPERGPSPPrpgklfafSAREPSANGAPGGGARAhrsagdepAAAEPEPRPEDAGSASPPAGCWRWDAPWGCGDNPPRV 1056
Cdd:PRK07764  433 PAPAPAPAPP--------SPAGNAPAGGAPSPPPA--------AAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAA 496

                         170       180
                  ....*....|....*....|....
gi 568955498 1057 PADVPADAPAQPAC-----WPTAR 1075
Cdd:PRK07764  497 PAAPAAPAGADDAAtlrerWPEIL 520
PHA03379 PHA03379
EBNA-3A; Provisional
 885-1067 5.45e-05

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 47.36  E-value: 5.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  885 EQQARRERDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGA--LLPPGPVLRLKQIIP--LQTRPPAPTgcapPPR 960
Cdd:PHA03379  403 EALEKASEPTYGTPRPPVEKPRPEVPQSLETATSHGSAQVPEPPPvhDLEPGPLHDQHSMAPcpVAQLPPGPL----QDL 478

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  961 SPADtRLPAFLslrflKAPERGPSP-PRPGKLFAfSAREPSANGAPGGGARAHRSagdEPAAAEPEPRP----EDAGSAS 1035
Cdd:PHA03379  479 EPGD-QLPGVV-----QDGRPACAPvPAPAGPIV-RPWEASLSQVPGVAFAPVMP---QPMPVEPVPVPtvalERPVCPA 548

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 568955498 1036 PPAGCW--------------RW-DAPWgcGDNPPRVPADVPA-DAPAQ 1067
Cdd:PHA03379  549 PPLIAMqgpgetsgivrvreRWrPAPW--TPNPPRSPSQMSVrDRLAR 594
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
908-1074 7.37e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 46.77  E-value: 7.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  908 DPVAERGAAKAkGSERPRRPGALLPPGPV---LRLKQIIPLQTRPPAPTGCAPPPRSPAdtrlPAFLSLRflKAPERGPS 984
Cdd:PRK07003  359 EPAVTGGGAPG-GGVPARVAGAVPAPGARaaaAVGASAVPAVTAVTGAAGAALAPKAAA----AAAATRA--EAPPAAPA 431

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  985 PPRPGKlfafSAREPSANGAPGGGARAHRSAGDEPAAAEPEPRPEDAGSASPPAGCWRWDAPWgcgdnPPRVPADVPADA 1064
Cdd:PRK07003  432 PPATAD----RGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAF-----EPAPRAAAPSAA 502

                         170
                  ....*....|
gi 568955498 1065 PAQPACWPTA 1074
Cdd:PRK07003  503 TPAAVPDARA 512
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
884-1061 8.16e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 46.77  E-value: 8.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  884 AEQQARRERDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPvlRLKQIIPLQTRPPAPTGCAPPPRSPA 963
Cdd:PRK07003  423 AEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADS--GSASAPASDAPPDAAFEPAPRAAAPS 500

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  964 DTRLPAFLSLRFLKAPERGPSPPRPGKLFAFSAREPSANGAP---GGGARAH----RSAG-----DEPAAAEPEPRPEDA 1031
Cdd:PRK07003  501 AATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPaarAGGAAAAldvlRNAGmrvssDRGARAAAAAKPAAA 580

                         170       180       190
                  ....*....|....*....|....*....|
gi 568955498 1032 GSASPPAGcwrwdapwgcgdnPPRVPADVP 1061
Cdd:PRK07003  581 PAAAPKPA-------------APRVAVQVP 597
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 897-1072 8.31e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.09  E-value: 8.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  897 REEARAEAPGPDPVAERGAAKAKGSERPRRPGA----LLPPGPVLRLKQIIPLQTRPPAPTGCAPPPRSPADTRLPAfls 972
Cdd:PHA03307  270 WEASGWNGPSSRPGPASSSSSPRERSPSPSPSSpgsgPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPS--- 346

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  973 lrflkaPERGPSPPRPgklfafsaREPSANGAPGGGARAHRSAGdEPAAAEPEPRPEDAGSASPPAGCWRWDAPWGCGDN 1052
Cdd:PHA03307  347 ------PSRSPSPSRP--------PPPADPSSPRKRPRPSRAPS-SPAASAGRPTRRRARAAVAGRARRRDATGRFPAGR 411

                         170       180
                  ....*....|....*....|
gi 568955498 1053 PPRVPADVPADAPAQPACWP 1072
Cdd:PHA03307  412 PRPSPLDAGAASGAFYARYP 431
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
897-1073 8.63e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.79  E-value: 8.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  897 REEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVLrlkqiiplQTRPPAPtgcapPPRSPADTRLPAflSLRFL 976
Cdd:PRK12323  420 AAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAA--------AARPAAA-----GPRPVAAAAAAA--PARAA 484

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  977 KAPERGPSPPR-------PGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAEPEPRPEDAGSASPPAgcwrwDAPwgc 1049
Cdd:PRK12323  485 PAAAPAPADDDpppweelPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRA-----AAA--- 556

                         170       180       190
                  ....*....|....*....|....*....|
gi 568955498 1050 gdnPPRVPADVPADA------PAQPACWPT 1073
Cdd:PRK12323  557 ---TEPVVAPRPPRAsasglpDMFDGDWPA 583
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 883-1039 1.18e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.13  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  883 HAEQQARRERDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGAllpPGPvlrlkqiiPLQTRPPAPTGCAPPPRSP 962
Cdd:PRK07764  656 HVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPA---PAP--------AATPPAGQADDPAAQPPQA 724

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568955498  963 ADTRLPAFLSlrflkAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAhrSAGDEPAAAEPEPRPEDAGSASPPAG 1039
Cdd:PRK07764  725 AQGASAPSPA-----ADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAA--APAAAPPPSPPSEEEEMAEDDAPSMD 794
PHA03247 PHA03247
large tegument protein UL36; Provisional
 900-1075 1.19e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  900 ARAEAPGPDP----------VAERGAAKAKGSERPRRPGALLPP----GPVLRLKQIIPlqTRPPAPTG--CAPPPRSPA 963
Cdd:PHA03247 2699 ADPPPPPPTPepaphalvsaTPLPPGPAAARQASPALPAAPAPPavpaGPATPGGPARP--ARPPTTAGppAPAPPAAPA 2776

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  964 DTRLPAflslrflkAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAEPEP-RPEDAGSASPPAGCWR 1042
Cdd:PHA03247 2777 AGPPRR--------LTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPtSAQPTAPPPPPGPPPP 2848

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 568955498 1043 WDAPWGC----GDNPPRVPADVPADAPAQPACWPTAR 1075
Cdd:PHA03247 2849 SLPLGGSvapgGDVRRRPPSRSPAAKPAAPARPPVRR 2885
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 884-1068 1.52e-04

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 45.33  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  884 AEQQARRERDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVlrlkQIIPLQTRPPAPTGCAPPPRSPA 963
Cdd:PTZ00436  173 ARKQELRKREKDRERARREDAAAAAAAKQKAAAKKAAAPSGKKSAKAAAPAKA----AAAPAKAAAPPAKAAAAPAKAAA 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  964 DTRLPAFLSLRFLKAPERGPSPPRPGKLFAFSAREPSANGA--PGGGARAHRSAGDEPAAAEPEPrpedAGSASPPAgcw 1041
Cdd:PTZ00436  249 APAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAapPAKAAAAPAKAAAAPAKAAAAP----AKAAAPPA--- 321

                         170       180
                  ....*....|....*....|....*..
gi 568955498 1042 RWDAPWGCGDNPPRVPADVPADAPAQP 1068
Cdd:PTZ00436  322 KAAAPPAKAATPPAKAAAPPAKAAAAP 348
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 890-1070 1.95e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.55  E-value: 1.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  890 RERDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVlrlkqiiplqtRPPAPTGCAPPPRSPADTRL-- 967
Cdd:PHA03307  790 VRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSESSGPA-----------RPPGAAARPPPARSSESSKSkp 858

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  968 PAFLSLRFLKAPERGPSPPRPgklfafsaREPSANGAPGGGARAHRSAGDEPAAAEPEPRPEDagSASPPAGcwrwDAPW 1047
Cdd:PHA03307  859 AAAGGRARGKNGRRRPRPPEP--------RARPGAAAPPKAAAAAPPAGAPAPRPRPAPRVKL--GPMPPGG----PDPR 924

                         170       180
                  ....*....|....*....|...
gi 568955498 1048 GCGDNPPRVPADVPadAPAQPAC 1070
Cdd:PHA03307  925 GGFRRVPPGDLHTP--APSAAAL 945
PHA03247 PHA03247
large tegument protein UL36; Provisional
 891-1073 2.31e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 2.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  891 ERDTGGREEARAE--APGPDPVAERGAAKAKGSERPRRPGALLP----PGPVLRLKQII---PLQTRPPA-PTGCAPPPR 960
Cdd:PHA03247  239 ERRVVISHPLRGDiaAPAPPPVVGEGADRAPETARGATGPPPPPeaaaPNGAAAPPDGVwgaALAGAPLAlPAPPDPPPP 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  961 SPAD----------------------TRLPAFL------------SLRFLKAPERGP---SPPRPGKLFAFSAREPSANG 1003
Cdd:PHA03247  319 APAGdaeeeddedgamevvsplprprQHYPLGFpkrrrptwtppsSLEDLSAGRHHPkraSLPTRKRRSARHAATPFARG 398

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498 1004 ApgGGARAHRSAGDEPAAAePEPRPEDAGSASPPAGCWRWDAPWGCGDNPPRVPADVPADAPAQPACWPT 1073
Cdd:PHA03247  399 P--GGDDQTRPAAPVPASV-PTPAPTPVPASAPPPPATPLPSAEPGSDDGPAPPPERQPPAPATEPAPDD 465
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 883-1072 2.58e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.16  E-value: 2.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  883 HAEQQARRERDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPP-------GPVLRLKQIIPLQTRPPAPTGC 955
Cdd:PHA03307   77 TEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPpspapdlSEMLRPVGSPGPPPAASPPAAG 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  956 APPPRSPADTRLPAFLSLRFLKAPERGPSPPRPGKLFAFSarePSANGAPGGGARAHRSAGDepAAAEPEPRPEDAGSAS 1035
Cdd:PHA03307  157 ASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPS---TPPAAASPRPPRRSSPISA--SASSPAPAPGRSAADD 231

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 568955498 1036 PPAGCWRWDAPWGCG-DNPPRVPADVPADAPAQPACWP 1072
Cdd:PHA03307  232 AGASSSDSSSSESSGcGWGPENECPLPRPAPITLPTRI 269
dnaA PRK14086
chromosomal replication initiator protein DnaA;
894-1039 3.61e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 44.43  E-value: 3.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  894 TGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALlPPGPVLRLKQIIPLQTRPPAP-TGCAPPPRSPADTRLPAFLS 972
Cdd:PRK14086  122 GGPRADDRPPGLPRQDQLPTARPAYPAYQQRPEPGAW-PRAADDYGWQQQRLGFPPRAPyASPASYAPEQERDREPYDAG 200

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568955498  973 LRFLKAPERGPSPPRPGKLFAFSAREPSANGAPGGGARaHRSAGDEPAAAEPEPRPEDAGSASPPAG 1039
Cdd:PRK14086  201 RPEYDQRRRDYDHPRPDWDRPRRDRTDRPEPPPGAGHV-HRGGPGPPERDDAPVVPIRPSAPGPLAA 266
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 903-1076 4.25e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.39  E-value: 4.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  903 EAPGPDPVAER-GAAKAKGSERPRRPGALLPPG--------PVLRLKQIIPLQTRPPAPTGCAPPPRSPADTRLPaflsl 973
Cdd:PHA03307  124 ASPPPSPAPDLsEMLRPVGSPGPPPAASPPAAGaspaavasDAASSRQAALPLSSPEETARAPSSPPAEPPPSTP----- 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  974 rflkAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSA-----------GDEPAAAEPEPRPEDAGSASPPAGCWR 1042
Cdd:PHA03307  199 ----PAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSsdssssessgcGWGPENECPLPRPAPITLPTRIWEASG 274

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 568955498 1043 W-----DAPWGCGDNPPRVPADVPA-DAPAQPACWPTARH 1076
Cdd:PHA03307  275 WngpssRPGPASSSSSPRERSPSPSpSSPGSGPAPSSPRA 314
PHA03247 PHA03247
large tegument protein UL36; Provisional
 902-1075 5.47e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 5.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  902 AEAPGPDPvaerGAAKAKGSERPRRPG----ALLPPGPV------LRLKQIIPLQTRPPAPTGCAPPPRSPAdtrLPAFL 971
Cdd:PHA03247 2491 AAGAAPDP----GGGGPPDPDAPPAPSrlapAILPDEPVgepvhpRMLTWIRGLEELASDDAGDPPPPLPPA---APPAA 2563

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  972 SLRFLKAPERGPSPPRPgklfAFSARE--PSANGAPGGGARAHRSAGDEPAAAEPEPRPEDAGSASPPAGCWRWDA-PWG 1048
Cdd:PHA03247 2564 PDRSVPPPRPAPRPSEP----AVTSRArrPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAAnEPD 2639

                         170       180
                  ....*....|....*....|....*..
gi 568955498 1049 CGDNPPRVPADVPADAPAQPACWPTAR 1075
Cdd:PHA03247 2640 PHPPPTVPPPERPRDDPAPGRVSRPRR 2666
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 884-1045 6.89e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 6.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  884 AEQQARRERDTGGREEARAEAPGPDPVAergAAKAKGSERPRRPGALLPPGPVlrlkqiiplqTRPPAPTGCAPPPRSPA 963
Cdd:PRK07764  378 LERLERRLGVAGGAGAPAAAAPSAAAAA---PAAAPAPAAAAPAAAAAPAPAA----------APQPAPAPAPAPAPPSP 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  964 DTRLPAflslrflkapERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAEPEPRPEDAGSASPPAGCWR- 1042
Cdd:PRK07764  445 AGNAPA----------GGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLRe 514


                  ....
gi 568955498 1043 -WDA 1045
Cdd:PRK07764  515 rWPE 518
PHA03381 PHA03381
tegument protein VP22; Provisional
 904-1056 8.24e-04

tegument protein VP22; Provisional


Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 42.69  E-value: 8.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  904 APGPDPVAERGAAKAKGSERPRRPGALLPPGPVlRLKQIIPLQTRPPAPTGCAPP---PRSPADTRLPAFLSLRFLKAPE 980
Cdd:PHA03381   27 SPDASPARVSFEEPADRARRGAGQARGRSQAER-RFHHYDEARADYPYYTGSSSEderPADPRPSRRPHAQPEASGPGPA 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  981 RGPSPPRPGKLFAFSAREPSANGAP----GGGARAHRSAGDEPAAAEPEPRPEDAGSASPPAGCWRW----------DAP 1046
Cdd:PHA03381  106 RGARGPAGSRGRGRRAESPSPRDPPnpkgASAPRGRKSACADSAALLDAPAPAAPKRQKTPAGLARKlhfstaptspTAP 185

                         170
                  ....*....|
gi 568955498 1047 WgcgdnPPRV 1056
Cdd:PHA03381  186 W-----TPRV 190
PHA03321 PHA03321
tegument protein VP11/12; Provisional
 892-1076 9.70e-04

tegument protein VP11/12; Provisional


Pssm-ID: 223041 [Multi-domain]  Cd Length: 694  Bit Score: 43.02  E-value: 9.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  892 RDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLP-PGPVLRLKQIIPL---QTRPPAPTGC-----------A 956
Cdd:PHA03321  428 RQPPGAPAPRRDNDPPPPPRARPGSTPACARRARAQRARDAgPEYVDPLGALRRLpagAAPPPEPAAApspatyytrmgG 507

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  957 PPPRSPAdtRLPAFLSLRflkaPERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAEPE----------- 1025
Cdd:PHA03321  508 GPPRLPP--RNRATETLR----PDWGPPAAAPPEQMEDPYLEPDDDRFDRRDGAAAAATSHPREAPAPDddpiyegvsds 581

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498 1026 ------------------PRPEDAGSA----SPPAGCW-RWDAP---WGCGD--NPPRVPADVPADAPAQPA--CWPTAR 1075
Cdd:PHA03321  582 eepvyeeiptprvyqnplPRPMEGAGEppdlDAPTSPWvEEENPiygWGDSPlfSPPPAARFPPPDPALSPEppALPAHR 661


                  .
gi 568955498 1076 H 1076
Cdd:PHA03321  662 P 662
PHA03247 PHA03247
large tegument protein UL36; Provisional
 904-1037 1.00e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  904 APGpDPVAERG---AAKAKGSERPRRPGALLPPGPVLRLKQIIPLQTRPPA--PTGCAPPPRSPADTRLPAFLSLRFLKA 978
Cdd:PHA03247 2857 APG-GDVRRRPpsrSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPErpPQPQAPPPPQPQPQPPPPPQPQPPPPP 2935

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568955498  979 PERGPSPPRPgklfafsAREPSANGAPGGGARAHRSAGDEPAAAE------PEPRPEDAGSASPP 1037
Cdd:PHA03247 2936 PPRPQPPLAP-------TTDPAGAGEPSGAVPQPWLGALVPGRVAvprfrvPQPAPSREAPASST 2993
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 892-1075 1.12e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.24  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  892 RDTGGREEARAEAPGPDPVAERGAAKakGSERPRRPGALL-PPGPVLRLKQIIPLQTRP-----PAPTGCAPPPRSPADT 965
Cdd:PHA03307  759 SNPSLVPAKLAEALALLEPAEPQRGA--GSSPPVRAEAAFrRPGRLRRSGPAADAASRTaskrkSRSHTPDGGSESSGPA 836

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  966 RlpaflslrflkAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAEPEPRPED----AGSASPPAGCW 1041
Cdd:PHA03307  837 R-----------PPGAAARPPPARSSESSKSKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKaaaaAPPAGAPAPRP 905

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 568955498 1042 RWDAPWGCGDNPPRVPAD------VPADAPAQPACWPTAR 1075
Cdd:PHA03307  906 RPAPRVKLGPMPPGGPDPrggfrrVPPGDLHTPAPSAAAL 945
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
945-1071 1.40e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.56  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  945 LQTRPPAPTGCAPPPRS---PADTRLPAFLSLRFL-KAPERGPSPPRPGKLFAFSAREPSANGAPGGGARA------HRS 1014
Cdd:PRK12323  361 LAFRPGQSGGGAGPATAaaaPVAQPAPAAAAPAAAaPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEalaaarQAS 440

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568955498 1015 AGDEPAAAEPEPRPED--AGSASPPAGCWRWDAPWGCGDNPPRVPADVPADAPAQPACW 1071
Cdd:PRK12323  441 ARGPGGAPAPAPAPAAapAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPW 499
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 909-1076 1.85e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.39  E-value: 1.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  909 PVAERGAAKAKGSERPRRPGALLP-PGPvlrlkqiiplqtRPPAPTGCAPPPRSPADTRLPAflslrflkAPERGPSPPR 987
Cdd:PRK14951  366 PAAAAEAAAPAEKKTPARPEAAAPaAAP------------VAQAAAAPAPAAAPAAAASAPA--------APPAAAPPAP 425

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  988 PgklfafSAREPSANGAPG-GGARAHRSAGDEPAAAEPEPRPEDAGSASPPAgcwrwdapwgcgdnpPRVPADVPADAPA 1066
Cdd:PRK14951  426 V------AAPAAAAPAAAPaAAPAAVALAPAPPAQAAPETVAIPVRVAPEPA---------------VASAAPAPAAAPA 484

                         170
                  ....*....|
gi 568955498 1067 QPACWPTARH 1076
Cdd:PRK14951  485 AARLTPTEEG 494
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 914-1044 1.96e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 42.36  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  914 GAAKAKGSERPRRPGALLPPGPvlrlKQIIPLQTRPPA---PTGCAPPPRSPADTRLPaflSLRFLKAPergPSPPRPGK 990
Cdd:PRK14959  379 SAPSGSAAEGPASGGAATIPTP----GTQGPQGTAPAAgmtPSSAAPATPAPSAAPSP---RVPWDDAP---PAPPRSGI 448

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568955498  991 LFAFSAREPSANGAPGGGARAHRSAGDEPAAAEPeprpeDAGSASPPAGCWRWD 1044
Cdd:PRK14959  449 PPRPAPRMPEASPVPGAPDSVASASDAPPTLGDP-----SDTAEHTPSGPRTWD 497
KLF14_N cd21576
N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as ...
 907-1076 1.98e-03

N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as Krueppel-like factor 14 or basic transcription element-binding protein 5/BTEB5) is a protein that in humans is encoded by the KLF14 gene. KLF14 regulates the transcription of various genes, including TGFbetaRII (the type II receptor for TGFbeta). KLF14 is expressed in many tissues, lacks introns, and is subject to parent-specific expression. It also appears to be a master regulator of gene expression in adipose tissue. KLF14 is associated with coronary artery disease, hypercholesterolemia, and type 2 diabetes. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF14 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF14.


Pssm-ID: 409238 [Multi-domain]  Cd Length: 195  Bit Score: 40.57  E-value: 1.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  907 PDPVAERGAAKAKGSERPRRPgALLPPGPvlRLKQIIPLQTRPPAPtgcaPPPRSPADTRLPAFLSLRFLK--APERGPS 984
Cdd:cd21576    29 PDPEGAGGAAGSEVGAAPPES-ALPGPGP--PGPAWVPPLLQVPAP----SPGAGGAAPHLLAASVLADLRggAGEGSRE 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  985 PPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEpAAAEPEPRPEDAGSASPPAGCWRWDAPWGCGDNPPRV-PADVPAD 1063
Cdd:cd21576   102 DSGEAPRASSGSSDPARGSSPTLGSEPAPASGED-AVSGPESSFGAPAIPSAPAAPGAPAVSGEVPGGAPGAgPAPAAGP 180

                         170
                  ....*....|....
gi 568955498 1064 APAQPACWPTA-RH 1076
Cdd:cd21576   181 APRRRPVTPAAkRH 194
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 884-1039 3.49e-03

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 41.20  E-value: 3.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  884 AEQQARRERDTGGREEARAEAPGPDPVAERGAAKAKGSERP-RRPGALLPPGPVLRLKQIIPLQTRPPAPTG-----CAP 957
Cdd:COG5180   208 DEAQEEPPDLTGGADHPRPEAASSPKVDPPSTSEARSRPATvDAQPEMRPPADAKERRRAAIGDTPAAEPPGlpvleAGS 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  958 PPRS---PADTRLPAFLSLRFLKAPERGPSPPRPGKLFAFSAREPSANGAPgggarahrsAGDEPAAAEPEPRPedagSA 1034
Cdd:COG5180   288 EPQSdapEAETARPIDVKGVASAPPATRPVRPPGGARDPGTPRPGQPTERP---------AGVPEAASDAGQPP----SA 354


                  ....*
gi 568955498 1035 SPPAG 1039
Cdd:COG5180   355 YPPAE 359
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 888-1075 6.42e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 6.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  888 ARRERDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVLRlkqiIPLQTRPPAPTGCAPPPRSPADTrl 967
Cdd:PHA03307  217 ASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPT----RIWEASGWNGPSSRPGPASSSSS-- 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  968 paflslrflkAPERGPS--PPRPGKLFAFSAREPSANGAP----GGGARAHRSAGDEPAAAEPEPRPEDAGSASPPAGcw 1041
Cdd:PHA03307  291 ----------PRERSPSpsPSSPGSGPAPSSPRASSSSSSsresSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPP-- 358

                         170       180       190
                  ....*....|....*....|....*....|....
gi 568955498 1042 rwdaPWGCGDNPPRVPADVPADAPAQPACWPTAR 1075
Cdd:PHA03307  359 ----PADPSSPRKRPRPSRAPSSPAASAGRPTRR 388
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 898-1045 8.36e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 40.11  E-value: 8.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  898 EEARAEAPGPDP--------VAERGAAKAKGSERPRR-------PGALLPPG-PV----LRLKQIIPLQTRPPAPTGCAP 957
Cdd:PRK14965  313 AELRAQAAAADAadlqrhltLLLRAEGEMAHASFPRLvlemallKMATLAPGaPVsellDRLEALERGAPAPPSAAWGAP 392

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  958 PPRSPAdtrlpaflslrflkapergpSPPRpgklfafsAREPSANGAPGGGARAHRSAGDEPAAAEPEPRPEDAGSASPP 1037
Cdd:PRK14965  393 TPAAPA--------------------APPP--------AAAPPVPPAAPARPAAARPAPAPAPPAAAAPPARSADPAAAA 444


                  ....*...
gi 568955498 1038 AGCWRWDA 1045
Cdd:PRK14965  445 SAGDRWRA 452
PHA03264 PHA03264
envelope glycoprotein D; Provisional
 891-1001 9.29e-03

envelope glycoprotein D; Provisional


Pssm-ID: 223029 [Multi-domain]  Cd Length: 416  Bit Score: 39.60  E-value: 9.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  891 ERDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPG--ALLPPG-PVLrlkQIIPLQtrPPAPTGCAPPPRSP----- 962
Cdd:PHA03264  292 VEDGAPGRETGGEGEGPEPAGRDGAAGGEPKPGPPRPApdADRPEGwPSL---EAITFP--PPTPATPAVPRARPvivgt 366

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 568955498  963 -----------ADTRLPAFLSLRFLKAperGPSPPRPGKLFAFSAREPSA 1001
Cdd:PHA03264  367 giaaaaiacvaAAGAVAYFVYTRRRGA---GPLPTKEKKLLAFGNVNYSA 413
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 884-1047 9.34e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.08  E-value: 9.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  884 AEQQARRERDTGGREEARAEAPGPDPVAERGAAKAkgserPRRPGALLPPGPvlrlkqiiPLQTRPPAPTGcAPPPRSPA 963
Cdd:PRK14951  370 AEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPA-----AAPAAAASAPAA--------PPAAAPPAPVA-APAAAAPA 435

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955498  964 dtrlpaflslrflKAPERGPSPPRPgklfafsAREPSANGAPGGGARAHRSAgDEPAAAEPEPRPEDAGSASPPAG---C 1040
Cdd:PRK14951  436 -------------AAPAAAPAAVAL-------APAPPAQAAPETVAIPVRVA-PEPAVASAAPAPAAAPAAARLTPteeG 494


                  ....*..
gi 568955498 1041 WRWDAPW 1047
Cdd:PRK14951  495 DVWHATV 501
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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