|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
11-410 |
1.84e-179 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 554.97 E-value: 1.84e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 11 SLT-RRRDAERRYTSSSADSEEGKGP-QKSYSSSETLKAYDQDARLAYGSRVKDMVPQEAEEFCRTGTNFTLRELGLGEM 88
Cdd:pfam06484 1 SLTkRRRDKERRYTSSSADSEECRVPtQKSYSSSETLKAFDHDSRMLYGNRVKDMVHKEADEFSRQGQNFSLRELGICEP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 89 TPPHGTLYRTDIGLPHCGYSMGASSDADLEADTVLSPEHPVRLWGRSTRSGRSSCLSSRANSNLTLTDTEHENT---ETG 165
Cdd:pfam06484 81 SPRHGLAYCTEMGLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKsdnENG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 166 APLHCSSASSTPIEQSPSPPPSPpaNESQRRLLGNGVAQPTPDSDSEEEFVPNSFLVKSGSASLGVAAnDHPSSLQNHPR 245
Cdd:pfam06484 161 PPIPPSSSSSSPVEQHSPPPPSL--NENQRPLLGNNASHPILDSDPDEEFSPNSYLVRTGSGPQSAPS-EQPPNFQNHSR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 246 LRTPPPPLPHAHTPNQHHAASINSLNRGNFTPRSNPSPAPTdHSLSGEPPagSAQEPTHAQDNWLLNSNIPLETRnlgkq 325
Cdd:pfam06484 238 LRTPPPPLPPPHKQNQHHHPSINSLNRSSLTNRRNPSPAPT-ASLPAELQ--STQESVQLQDSWVLNSNVPLETR----- 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 326 pflgtlqdnliemdilsasrhdgaysdgHFLFKPG-GTSPLFCTTSPGYPLTSSTVYSPPPRPLPRSTFSRPAFNLKKPS 404
Cdd:pfam06484 310 ----------------------------HFLFKTGtGTTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPY 361
|
....*.
gi 568950580 405 KYCNWK 410
Cdd:pfam06484 362 KYCSWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1294-1635 |
3.93e-47 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 173.10 E-value: 3.93e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1294 GLADGNKLLA----PVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILEMRNKDFRHSHSPAHKYY----LATDPmSGA 1363
Cdd:cd14953 11 GFSGGGGTAArfnsPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGGAAAQFNtpsgVAVDA-AGN 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1364 VFLSDTNSRRVFKVKSTTVVKdlvknseVVAGTGDQclpfddtRCGDGGKATEATLTNPRGITVDKFGLIYFVDGT--MI 1441
Cdd:cd14953 90 LYVADTGNHRIRKITPDGVVS-------TLAGTGTA-------GFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1442 RRVDQNGIISTLLGsndlTSARPLSCDSVMeiSQVRLEWPTDLAINPMDNsLYVLD--NNVVLQISENHQVRIVAGRpmh 1519
Cdd:cd14953 156 RKITPDGVVTTVAG----TGGAGYAGDGPA--TAAQFNNPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGT--- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1520 cqvpGIDHFLLSKVAIHATLESATALAVSHNGVLYIAETDEkkiNRIRQVTTSGEISLVAGAPSGcdckndancdcFSGD 1599
Cdd:cd14953 226 ----GTAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGD 287
|
330 340 350
....*....|....*....|....*....|....*.
gi 568950580 1600 DGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFI 1635
Cdd:cd14953 288 GGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2757-2834 |
3.22e-37 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 135.43 E-value: 3.22e-37
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568950580 2757 EEKVRVLELARQRAVRQAWAREQQRLREGEEGLRAWTDGEKQQVLNTGRVQGYDGFFVTSVEQYPELSDSANNIHFMR 2834
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1668-2533 |
1.58e-33 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 142.59 E-value: 1.58e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1668 LYTQSLPTGDYLYNFTYTGDGDITHITDNNGNMVNVRRDSTGMPLWLVVPDGQVYWVTMGTNSALRSVTTQGHELAMMTY 1747
Cdd:COG3209 191 LATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTGAS 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1748 HGNSGLLATKSNENGW--TTFYEYDSFGRLTNVTFPTGQVSSFRSDTDSSVHVQVETSSKDDVTITTNLSASGAFYTLLQ 1825
Cdd:COG3209 271 GAGLDASTGTGGAGGSnaAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTTVG 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1826 DQVRNSYYIGADGSLRLLLANGMEVALQTEPHLLAGTVNPTVGKRNVTLPIDNGLNLVEWRQRKEQARGQVTVFGRRLRV 1905
Cdd:COG3209 351 GGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGG 430
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1906 HNRNLLSLDFDRVTRTEKIYDDHRKFTLRILYDQAGRPSLWSPSSRLNGVNVTYSPGGHIAGIQRGIMSERMEYDQAGRI 1985
Cdd:COG3209 431 TATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGGTT 510
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1986 TSRIFADgkmWSYTYLEKSMVLHLHSQRQYIFEFDKNDRLSSVTMPNVARQTLETIRSVGYYRNIYQPPEGNASVIQDFT 2065
Cdd:COG3209 511 TTTAGAR---GLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGG 587
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2066 EDGHLLHTFYLGTGRRVIYKYGKLSKLAETLYDTTKVSFTYDETAGMLKTVNLQNEGFTCTIRYRQIGPLIDRQIFRFTE 2145
Cdd:COG3209 588 TATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTGT 667
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2146 EGMVNARFDYNYDNSFRVTSmQAVINETPLPIDLYRYDDVSGKTEQFGKFGVIYYDINQIITTAVMTHTKHFDAYGRMKE 2225
Cdd:COG3209 668 GVTAGLTTLATGGTTVGGGT-GTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTT 746
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2226 VQYEIFRSLMYWmTVQYDNMGRVVKKELKVGPYANTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNLHLLSPGNSAR 2305
Cdd:COG3209 747 TSTTTTTTAGAL-TYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSVITVGSGG 825
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2306 LTPL-----RYDLRDRITRLgdvqykmdEDGFLRQRGGDVFEYNSAGLLIKAynRASGWSVRYRYDGLGRRVSSKSSHSH 2380
Cdd:COG3209 826 GTDLqdrtyTYDAAGNITSI--------TDALRAGTLTQTYTYDALGRLTSA--TDPGTTESYTYDANGNLTSRTDGGTT 895
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2381 HLQFFYADLtnPTKVTHlynhSSSEITSLYYDLQGHlfamelssgdefyiaCDNIGTPLAVFSGTGLMIKQILYTAYGEI 2460
Cdd:COG3209 896 TYTYDALGR--LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFGNL 954
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568950580 2461 YMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDhelwkrlssnSIVP---FHLYMFKNNNPISNS 2533
Cdd:COG3209 955 LAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD----------PIGLaggLNLYAYVGNNPVNYV 1020
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2454-2533 |
2.91e-10 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 58.67 E-value: 2.91e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2454 YTAYGEIyMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDhelwkrlssnsivPF------HLYMFKNN 2527
Cdd:TIGR03696 1 YDPYGEV-LSESGAAPNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD-------------PIglggglNLYAYVGN 66
|
....*.
gi 568950580 2528 NPISNS 2533
Cdd:TIGR03696 67 NPVNWV 72
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
1952-2370 |
3.48e-09 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 62.71 E-value: 3.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1952 LNGVNVTYSPGGhiAGIQRGIMSE-------RMEYDQAGRITSRIFADGKMWSYTyleksmvLHLHSqrqyifefdknDR 2024
Cdd:NF041261 401 LNRREVLHTEGE--GGLKRVVKKEhadgsvtRSGYDAAGRLTAQTDAAGRRTEYS-------LNVVS-----------GD 460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2025 LSSVTMPNVarqtletiRSVGYYRNiyqppegnasviqdfteDGHLLHTFYLGTGRRVIYKYGKLSKL-AETLYDTTKVS 2103
Cdd:NF041261 461 ITDITTPDG--------RETKFYYN-----------------DGNQLTSVTSPDGLESRREYDEPGRLvSETSRSGETTR 515
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2104 FTYDETAGMLKTVNLQNEGFTCTIRYRQIGplidrQIFRFTEEGMVNARFDYNydnsfRVTSMQAVINETPlpIDLYR-Y 2182
Cdd:NF041261 516 YRYDDPHSELPATTTDATGSTKQMTWSRYG-----QLLAFTDCSGYQTRYEYD-----RFGQMTAVHREEG--ISTYRrY 583
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2183 DD----VSGKTEQfGKFGVIYY----DINQIITTAVMTHTKHFDAYGR-MKEVQYEIFRSLmywmtvQYDNMGRVVKKEL 2253
Cdd:NF041261 584 DNrgqlTSVKDAQ-GRETRYEYnaagDLTAVITPDGNRSETQYDAWGKaVSTTQGGLTRSM------EYDAAGRITTLTN 656
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2254 KvgpyaNTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNlhLLSPGNSARLTPLRYDLRDRITRL---GDV--QYKMD 2328
Cdd:NF041261 657 E-----NGSHSTFLYDALDRLVQQRGFDGRTQRYHYDLTGK--LTQSEDEGLVTLWHYDESDRITHRtvnGEPaeQWQYD 729
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 568950580 2329 EDGFLRQrggdvFEYNSAGLLIkaynrasgwSVRYRYDGLGR 2370
Cdd:NF041261 730 EHGWLTD-----ISHLSEGHRV---------AVHYGYDDKGR 757
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1304-1635 |
3.70e-09 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 60.42 E-value: 3.70e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1304 PVALTCGSDGSLYVGDF--NYIRRIFP-SGNVTnilEMRNKDFRHSHSpahkyyLATDPmSGAVFLSDTNSRRVFKVKST 1380
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLDPaTGEFT---EYPLGGGSGPHG------IAVDP-DGNLWFTDNGNNRIGRIDPK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1381 TvvkdlvKNSEVVAGTGDQCLPFddtrcgdggkateatltnprGITVDKFGLIYFVDGT--MIRRVD-QNGIISTLLGsn 1457
Cdd:COG4257 89 T------GEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLDpATGEVTEFPL-- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1458 DLTSARplscdsvmeisqvrlewPTDLAINPmDNSLYVLDNnvvlqisENHQVRIVAGRPMHcqvpgidhflLSKVAIHA 1537
Cdd:COG4257 141 PTGGAG-----------------PYGIAVDP-DGNLWVTDF-------GANAIGRIDPDTGT----------LTEYALPT 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1538 TLESATALAVSHNGVLYIAETDEKKINRIRqvTTSGEISLVAGAPSGCDckndancdcfsgddgyakdaklntPSSLAVC 1617
Cdd:COG4257 186 PGAGPRGLAVDPDGNLWVADTGSGRIGRFD--PKTGTVTEYPLPGGGAR------------------------PYGVAVD 239
|
330
....*....|....*...
gi 568950580 1618 ADGELYVADLGNIRIRFI 1635
Cdd:COG4257 240 GDGRVWFAESGANRIVRF 257
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
2180-2516 |
2.48e-06 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 53.47 E-value: 2.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2180 YRYDDVSGKTEQFGKFGVIY---YDINQIITTAVMT-----HT----------KHFDAYGRMKEVQYEIFRSLmywmTVQ 2241
Cdd:NF041261 367 YRYDDTGRVTEQLNPAGLSYryqYEQDRITITDSLNrrevlHTegegglkrvvKKEHADGSVTRSGYDAAGRL----TAQ 442
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2242 YDNMGRVVKKELKV---------GPYANTTRYSYeyDADGQLQTVSINDKPLWRYSYDLNGNLhLLSPGNSARLTPLRYD 2312
Cdd:NF041261 443 TDAAGRRTEYSLNVvsgditditTPDGRETKFYY--NDGNQLTSVTSPDGLESRREYDEPGRL-VSETSRSGETTRYRYD 519
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2313 lrDRITRLGDVqyKMDEDGFLRQrggdvFEYNSAGLLIkAYNRASGWSVRYRYDGLGRRVSSKSSHSHHLqffYADLTNP 2392
Cdd:NF041261 520 --DPHSELPAT--TTDATGSTKQ-----MTWSRYGQLL-AFTDCSGYQTRYEYDRFGQMTAVHREEGIST---YRRYDNR 586
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2393 TKVTHLYNHSSSEiTSLYYDLQGHLFAMELSSGDEFYIACDNIGTPLAVFSGtGLMiKQILYTAYGEIYMDTNPNfqiii 2472
Cdd:NF041261 587 GQLTSVKDAQGRE-TRYEYNAAGDLTAVITPDGNRSETQYDAWGKAVSTTQG-GLT-RSMEYDAAGRITTLTNEN----- 658
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 568950580 2473 GYHGG-LYDPLTKLVHMG-------RRDYDvLAGRWTSPDHE----LWKRLSSNSI 2516
Cdd:NF041261 659 GSHSTfLYDALDRLVQQRgfdgrtqRYHYD-LTGKLTQSEDEglvtLWHYDESDRI 713
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
1339-1639 |
1.07e-05 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 51.39 E-value: 1.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1339 RNKDFRHSHSPAhKY--YLATDPMSGAVFLSDTNSRRVfkvksttVVKDLVKNSEV-VAGTGDQCL---PFDDtrcgdgg 1412
Cdd:PLN02919 556 KDNDPRLLTSPL-KFpgKLAIDLLNNRLFISDSNHNRI-------VVTDLDGNFIVqIGSTGEEGLrdgSFED------- 620
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1413 kateATLTNPRGITVDKFGLIYFVDGT---MIRRVD-QNGIISTLLGS----NDLTSARPLScdsvmeiSQVrLEWPTDL 1484
Cdd:PLN02919 621 ----ATFNRPQGLAYNAKKNLLYVADTenhALREIDfVNETVRTLAGNgtkgSDYQGGKKGT-------SQV-LNSPWDV 688
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1485 AINPMDNSLYV------------LDNNVVLQISENHQVRIVAGR----PMHCQVPGI------DHFLLSK---------- 1532
Cdd:PLN02919 689 CFEPVNEKVYIamagqhqiweynISDGVTRVFSGDGYERNLNGSsgtsTSFAQPSGIslspdlKELYIADsesssirald 768
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1533 ----------------------------VAIHATLESATALAVSHNGVLYIAETDEKKINRIRQVTtsGEISLVAGAPSG 1584
Cdd:PLN02919 769 lktggsrllaggdptfsdnlfkfgdhdgVGSEVLLQHPLGVLCAKDGQIYVADSYNHKIKKLDPAT--KRVTTLAGTGKA 846
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 568950580 1585 cdckndancdcfSGDDGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFIRKNK 1639
Cdd:PLN02919 847 ------------GFKDGKALKAQLSEPAGLALGENGRLFVADTNNSLIRYLDLNK 889
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
818-861 |
4.56e-05 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 43.00 E-value: 4.56e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 568950580 818 CEDGWMGAACDqRACHPRCAE--HGTC-RDGKCECSPGWNGEHCTIA 861
Cdd:pfam01414 1 CDENYYGSTCS-KFCRPRDDKfgHYTCdANGNKVCLPGWTGPYCDKP 46
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1752-1784 |
5.90e-04 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 39.50 E-value: 5.90e-04
10 20 30
....*....|....*....|....*....|...
gi 568950580 1752 GLLATKSNENGWTTFYEYDSFGRLTNVTFPTGQ 1784
Cdd:pfam05593 5 GRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
|
|
| Keratin_B2 |
pfam01500 |
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ... |
699-847 |
1.30e-03 |
|
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.
Pssm-ID: 366678 [Multi-domain] Cd Length: 161 Bit Score: 42.09 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 699 TNQCIDVACSSHGTCimGTCICNPGYKGESCEEVDCMDPTCS----SRGVCVRGECHCSVgwgGTNCETPraTCLDQCS- 773
Cdd:pfam01500 6 TSFCGFPTCSTGGTC--GSGCCQPCCCQSSCCRPSCCQTSCCqpttFQSSCCRPTCQPCC---QTSCCQP--TCCQTSSc 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 774 -------GHGTfLPDTGLCNCDPSWTGHDCSIEICAADCGGHGVCVGGTCrCEDGWMGAACdqraCHPRCAEHGTCRDGK 846
Cdd:pfam01500 79 qtgcggiGYGQ-EGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTC-CQLHHAQASC----CRPSYCGQSCCRPAC 152
|
.
gi 568950580 847 C 847
Cdd:pfam01500 153 C 153
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1545-1731 |
2.12e-03 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 42.64 E-value: 2.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1545 LAVSHNGVLYIAETDEkkiNRIRQVTTSGEISLVAGapsgcdckndancdcfSGDDGyakDAKLNTPSSLAVCADGELYV 1624
Cdd:cd14957 23 IAVDSAGNIYVADTGN---NRIQVFTSSGVYSYSIG----------------SGGTG---SGQFNSPYGIAVDSNGNIYV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1625 ADLGNIRIRfirknkpFLNTQNMYElsspidqelYLFDTSGkhlytQSLPTGDYLYNFTYTGDGDItHITDNNGNMVNVr 1704
Cdd:cd14957 81 ADTDNNRIQ-------VFNSSGVYQ---------YSIGTGG-----SGDGQFNGPYGIAVDSNGNI-YVADTGNHRIQV- 137
|
170 180
....*....|....*....|....*..
gi 568950580 1705 RDSTGmplwlvvpdgqVYWVTMGTNSA 1731
Cdd:cd14957 138 FTSSG-----------TFSYSIGSGGT 153
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
707-730 |
3.92e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 3.92e-03
10 20
....*....|....*....|....*...
gi 568950580 707 CSSHGTCIMG----TCICNPGYKGESCE 730
Cdd:cd00054 11 CQNGGTCVNTvgsyRCSCPPGYTGRNCE 38
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
11-410 |
1.84e-179 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 554.97 E-value: 1.84e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 11 SLT-RRRDAERRYTSSSADSEEGKGP-QKSYSSSETLKAYDQDARLAYGSRVKDMVPQEAEEFCRTGTNFTLRELGLGEM 88
Cdd:pfam06484 1 SLTkRRRDKERRYTSSSADSEECRVPtQKSYSSSETLKAFDHDSRMLYGNRVKDMVHKEADEFSRQGQNFSLRELGICEP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 89 TPPHGTLYRTDIGLPHCGYSMGASSDADLEADTVLSPEHPVRLWGRSTRSGRSSCLSSRANSNLTLTDTEHENT---ETG 165
Cdd:pfam06484 81 SPRHGLAYCTEMGLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKsdnENG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 166 APLHCSSASSTPIEQSPSPPPSPpaNESQRRLLGNGVAQPTPDSDSEEEFVPNSFLVKSGSASLGVAAnDHPSSLQNHPR 245
Cdd:pfam06484 161 PPIPPSSSSSSPVEQHSPPPPSL--NENQRPLLGNNASHPILDSDPDEEFSPNSYLVRTGSGPQSAPS-EQPPNFQNHSR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 246 LRTPPPPLPHAHTPNQHHAASINSLNRGNFTPRSNPSPAPTdHSLSGEPPagSAQEPTHAQDNWLLNSNIPLETRnlgkq 325
Cdd:pfam06484 238 LRTPPPPLPPPHKQNQHHHPSINSLNRSSLTNRRNPSPAPT-ASLPAELQ--STQESVQLQDSWVLNSNVPLETR----- 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 326 pflgtlqdnliemdilsasrhdgaysdgHFLFKPG-GTSPLFCTTSPGYPLTSSTVYSPPPRPLPRSTFSRPAFNLKKPS 404
Cdd:pfam06484 310 ----------------------------HFLFKTGtGTTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPY 361
|
....*.
gi 568950580 405 KYCNWK 410
Cdd:pfam06484 362 KYCSWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1294-1635 |
3.93e-47 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 173.10 E-value: 3.93e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1294 GLADGNKLLA----PVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILEMRNKDFRHSHSPAHKYY----LATDPmSGA 1363
Cdd:cd14953 11 GFSGGGGTAArfnsPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGGAAAQFNtpsgVAVDA-AGN 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1364 VFLSDTNSRRVFKVKSTTVVKdlvknseVVAGTGDQclpfddtRCGDGGKATEATLTNPRGITVDKFGLIYFVDGT--MI 1441
Cdd:cd14953 90 LYVADTGNHRIRKITPDGVVS-------TLAGTGTA-------GFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1442 RRVDQNGIISTLLGsndlTSARPLSCDSVMeiSQVRLEWPTDLAINPMDNsLYVLD--NNVVLQISENHQVRIVAGRpmh 1519
Cdd:cd14953 156 RKITPDGVVTTVAG----TGGAGYAGDGPA--TAAQFNNPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGT--- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1520 cqvpGIDHFLLSKVAIHATLESATALAVSHNGVLYIAETDEkkiNRIRQVTTSGEISLVAGAPSGcdckndancdcFSGD 1599
Cdd:cd14953 226 ----GTAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGD 287
|
330 340 350
....*....|....*....|....*....|....*.
gi 568950580 1600 DGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFI 1635
Cdd:cd14953 288 GGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2757-2834 |
3.22e-37 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 135.43 E-value: 3.22e-37
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568950580 2757 EEKVRVLELARQRAVRQAWAREQQRLREGEEGLRAWTDGEKQQVLNTGRVQGYDGFFVTSVEQYPELSDSANNIHFMR 2834
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1668-2533 |
1.58e-33 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 142.59 E-value: 1.58e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1668 LYTQSLPTGDYLYNFTYTGDGDITHITDNNGNMVNVRRDSTGMPLWLVVPDGQVYWVTMGTNSALRSVTTQGHELAMMTY 1747
Cdd:COG3209 191 LATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTGAS 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1748 HGNSGLLATKSNENGW--TTFYEYDSFGRLTNVTFPTGQVSSFRSDTDSSVHVQVETSSKDDVTITTNLSASGAFYTLLQ 1825
Cdd:COG3209 271 GAGLDASTGTGGAGGSnaAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTTVG 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1826 DQVRNSYYIGADGSLRLLLANGMEVALQTEPHLLAGTVNPTVGKRNVTLPIDNGLNLVEWRQRKEQARGQVTVFGRRLRV 1905
Cdd:COG3209 351 GGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGG 430
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1906 HNRNLLSLDFDRVTRTEKIYDDHRKFTLRILYDQAGRPSLWSPSSRLNGVNVTYSPGGHIAGIQRGIMSERMEYDQAGRI 1985
Cdd:COG3209 431 TATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGGTT 510
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1986 TSRIFADgkmWSYTYLEKSMVLHLHSQRQYIFEFDKNDRLSSVTMPNVARQTLETIRSVGYYRNIYQPPEGNASVIQDFT 2065
Cdd:COG3209 511 TTTAGAR---GLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGG 587
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2066 EDGHLLHTFYLGTGRRVIYKYGKLSKLAETLYDTTKVSFTYDETAGMLKTVNLQNEGFTCTIRYRQIGPLIDRQIFRFTE 2145
Cdd:COG3209 588 TATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTGT 667
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2146 EGMVNARFDYNYDNSFRVTSmQAVINETPLPIDLYRYDDVSGKTEQFGKFGVIYYDINQIITTAVMTHTKHFDAYGRMKE 2225
Cdd:COG3209 668 GVTAGLTTLATGGTTVGGGT-GTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTT 746
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2226 VQYEIFRSLMYWmTVQYDNMGRVVKKELKVGPYANTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNLHLLSPGNSAR 2305
Cdd:COG3209 747 TSTTTTTTAGAL-TYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSVITVGSGG 825
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2306 LTPL-----RYDLRDRITRLgdvqykmdEDGFLRQRGGDVFEYNSAGLLIKAynRASGWSVRYRYDGLGRRVSSKSSHSH 2380
Cdd:COG3209 826 GTDLqdrtyTYDAAGNITSI--------TDALRAGTLTQTYTYDALGRLTSA--TDPGTTESYTYDANGNLTSRTDGGTT 895
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2381 HLQFFYADLtnPTKVTHlynhSSSEITSLYYDLQGHlfamelssgdefyiaCDNIGTPLAVFSGTGLMIKQILYTAYGEI 2460
Cdd:COG3209 896 TYTYDALGR--LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFGNL 954
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568950580 2461 YMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDhelwkrlssnSIVP---FHLYMFKNNNPISNS 2533
Cdd:COG3209 955 LAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD----------PIGLaggLNLYAYVGNNPVNYV 1020
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1299-1635 |
6.94e-19 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 89.30 E-value: 6.94e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1299 NKLLAPVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILEMRNKDFRHSHSPAHkyyLATDPmSGAVFLSDTNSRRVFK 1376
Cdd:cd05819 5 GELNNPQGIAVDSSGNIYVADTgnNRIQVFDPDGNFITSFGSFGSGDGQFNEPAG---VAVDS-DGNLYVADTGNHRIQK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1377 VKSTTVVKDlvknseVVAGTGDQCLPFDdtrcgdggkateatltNPRGITVDKFGLIYFVDgTM---IRRVDQNGIISTL 1453
Cdd:cd05819 81 FDPDGNFLA------SFGGSGDGDGEFN----------------GPRGIAVDSSGNIYVAD-TGnhrIQKFDPDGEFLTT 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1454 LGSNDLTSARplscdsvmeisqvrLEWPTDLAINPmDNSLYVLDnnvvlqiSENHQVRIVAgrpmhcqvPGiDHFLL--- 1530
Cdd:cd05819 138 FGSGGSGPGQ--------------FNGPTGVAVDS-DGNIYVAD-------TGNHRIQVFD--------PD-GNFLTtfg 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1531 SKVAIHATLESATALAVSHNGVLYIAETDEkkiNRIRQVTTSGEISLVAGAPSGcdckndancdcfsgddgyaKDAKLNT 1610
Cdd:cd05819 187 STGTGPGQFNYPTGIAVDSDGNIYVADSGN---NRVQVFDPDGAGFGGNGNFLG-------------------SDGQFNR 244
|
330 340
....*....|....*....|....*
gi 568950580 1611 PSSLAVCADGELYVADLGNIRIRFI 1635
Cdd:cd05819 245 PSGLAVDSDGNLYVADTGNNRIQVF 269
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1419-1729 |
3.70e-17 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 84.29 E-value: 3.70e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1419 LTNPRGITVDKFGLIYFVDGTM--IRRVDQNGIISTLLGSNDltsarplscdsvmeISQVRLEWPTDLAINPmDNSLYVL 1496
Cdd:cd05819 7 LNNPQGIAVDSSGNIYVADTGNnrIQVFDPDGNFITSFGSFG--------------SGDGQFNEPAGVAVDS-DGNLYVA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1497 D--NNVVLQISENHQVRIVAGRPmhcqvpGIDHFLLSkvaihatleSATALAVSHNGVLYIAETDEkkiNRIRQVTTSGE 1574
Cdd:cd05819 72 DtgNHRIQKFDPDGNFLASFGGS------GDGDGEFN---------GPRGIAVDSSGNIYVADTGN---HRIQKFDPDGE 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1575 ISLVAGAPSGCDckndancdcfsgddgyakdAKLNTPSSLAVCADGELYVADLGNIRIRFIrknkpflntqnmyelsSPI 1654
Cdd:cd05819 134 FLTTFGSGGSGP-------------------GQFNGPTGVAVDSDGNIYVADTGNHRIQVF----------------DPD 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1655 DQELYLFDTSGKHLYTQSLPTG------DYLYnFTYTGDGDITHITDN------NGNmVNVRRDSTGMPLWLVV-PDGQV 1721
Cdd:cd05819 179 GNFLTTFGSTGTGPGQFNYPTGiavdsdGNIY-VADSGNNRVQVFDPDgagfggNGN-FLGSDGQFNRPSGLAVdSDGNL 256
|
....*...
gi 568950580 1722 YWVTMGTN 1729
Cdd:cd05819 257 YVADTGNN 264
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1291-1504 |
2.54e-14 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 76.80 E-value: 2.54e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1291 SCNGLADGNKLLAPVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNilemrnkdfrhshspahkyylatdpmsgavflsd 1368
Cdd:cd14953 176 AGDGPATAAQFNNPTGVAVDAAGNLYVADRgnHRIRKITPDGVVTT---------------------------------- 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1369 tnsrrvfkvksttvvkdlvknsevVAGTGDQclPFddtrcGDGGKATEATLTNPRGITVDKFGLIYFVD---GTmIRRVD 1445
Cdd:cd14953 222 ------------------------VAGTGTA--GF-----SGDGGATAAQLNNPTGVAVDAAGNLYVADsgnHR-IRKIT 269
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568950580 1446 QNGIISTLLGSndlTSARPLSCDSVmeiSQVRLEWPTDLAINPmDNSLYVLD--NNVVLQI 1504
Cdd:cd14953 270 PAGVVTTVAGG---GAGFSGDGGPA---TSAQFNNPTGVAVDA-AGNLYVADtgNNRIRKI 323
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1297-1566 |
2.23e-13 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 73.12 E-value: 2.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1297 DGNKLLAPVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILEMRNKDFRHSHSPahkYYLATDPmSGAVFLSDTNSRRV 1374
Cdd:cd05819 50 GDGQFNEPAGVAVDSDGNLYVADTgnHRIQKFDPDGNFLASFGGSGDGDGEFNGP---RGIAVDS-SGNIYVADTGNHRI 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1375 FKVKSttvvkdlvkNSEVVAGTGdqclpfddtrcgdGGKATEATLTNPRGITVDKFGLIYFVDGT--MIRRVDQNGIIST 1452
Cdd:cd05819 126 QKFDP---------DGEFLTTFG-------------SGGSGPGQFNGPTGVAVDSDGNIYVADTGnhRIQVFDPDGNFLT 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1453 LLGSNDLTSArplscdsvmeisqvRLEWPTDLAINPMDNsLYVLD--NNVVLQISENHQVRIVAGrpmhcqvpgidhfll 1530
Cdd:cd05819 184 TFGSTGTGPG--------------QFNYPTGIAVDSDGN-IYVADsgNNRVQVFDPDGAGFGGNG--------------- 233
|
250 260 270
....*....|....*....|....*....|....*.
gi 568950580 1531 SKVAIHATLESATALAVSHNGVLYIAETDEKKINRI 1566
Cdd:cd05819 234 NFLGSDGQFNRPSGLAVDSDGNLYVADTGNNRIQVF 269
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2454-2533 |
2.91e-10 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 58.67 E-value: 2.91e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2454 YTAYGEIyMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDhelwkrlssnsivPF------HLYMFKNN 2527
Cdd:TIGR03696 1 YDPYGEV-LSESGAAPNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD-------------PIglggglNLYAYVGN 66
|
....*.
gi 568950580 2528 NPISNS 2533
Cdd:TIGR03696 67 NPVNWV 72
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1355-1632 |
1.83e-09 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 61.07 E-value: 1.83e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1355 LATDPmSGAVFLSDTNSRRVFKVksttvvkdlvknsevVAGTGDQC-LPFDDtrcgdggkateatLTNPRGITVDKFGLI 1433
Cdd:cd14952 15 VAVDA-AGNVYVADSGNNRVLKL---------------AAGSTTQTvLPFTG-------------LYQPQGVAVDAAGTV 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1434 YFVDGtmirrvDQNGIISTLLGSNDLTsarPLSCDSvmeisqvrLEWPTDLAINPMDNsLYVLD--NNVVLqisenhqvR 1511
Cdd:cd14952 66 YVTDF------GNNRVLKLAAGSTTQT---VLPFTG--------LNDPTGVAVDAAGN-VYVADtgNNRVL--------K 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1512 IVAGRPMHCQVPgidhFllskvaihATLESATALAVSHNGVLYIAETDEkkiNRIRQvttsgeisLVAGA------Psgc 1585
Cdd:cd14952 120 LAAGSNTQTVLP----F--------TGLSNPDGVAVDGAGNVYVTDTGN---NRVLK--------LAAGSttqtvlP--- 173
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 568950580 1586 dckndancdcFSGddgyakdakLNTPSSLAVCADGELYVADLGNIRI 1632
Cdd:cd14952 174 ----------FTG---------LNSPSGVAVDTAGNVYVTDHGNNRV 201
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
1952-2370 |
3.48e-09 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 62.71 E-value: 3.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1952 LNGVNVTYSPGGhiAGIQRGIMSE-------RMEYDQAGRITSRIFADGKMWSYTyleksmvLHLHSqrqyifefdknDR 2024
Cdd:NF041261 401 LNRREVLHTEGE--GGLKRVVKKEhadgsvtRSGYDAAGRLTAQTDAAGRRTEYS-------LNVVS-----------GD 460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2025 LSSVTMPNVarqtletiRSVGYYRNiyqppegnasviqdfteDGHLLHTFYLGTGRRVIYKYGKLSKL-AETLYDTTKVS 2103
Cdd:NF041261 461 ITDITTPDG--------RETKFYYN-----------------DGNQLTSVTSPDGLESRREYDEPGRLvSETSRSGETTR 515
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2104 FTYDETAGMLKTVNLQNEGFTCTIRYRQIGplidrQIFRFTEEGMVNARFDYNydnsfRVTSMQAVINETPlpIDLYR-Y 2182
Cdd:NF041261 516 YRYDDPHSELPATTTDATGSTKQMTWSRYG-----QLLAFTDCSGYQTRYEYD-----RFGQMTAVHREEG--ISTYRrY 583
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2183 DD----VSGKTEQfGKFGVIYY----DINQIITTAVMTHTKHFDAYGR-MKEVQYEIFRSLmywmtvQYDNMGRVVKKEL 2253
Cdd:NF041261 584 DNrgqlTSVKDAQ-GRETRYEYnaagDLTAVITPDGNRSETQYDAWGKaVSTTQGGLTRSM------EYDAAGRITTLTN 656
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2254 KvgpyaNTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNlhLLSPGNSARLTPLRYDLRDRITRL---GDV--QYKMD 2328
Cdd:NF041261 657 E-----NGSHSTFLYDALDRLVQQRGFDGRTQRYHYDLTGK--LTQSEDEGLVTLWHYDESDRITHRtvnGEPaeQWQYD 729
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 568950580 2329 EDGFLRQrggdvFEYNSAGLLIkaynrasgwSVRYRYDGLGR 2370
Cdd:NF041261 730 EHGWLTD-----ISHLSEGHRV---------AVHYGYDDKGR 757
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1304-1635 |
3.70e-09 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 60.42 E-value: 3.70e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1304 PVALTCGSDGSLYVGDF--NYIRRIFP-SGNVTnilEMRNKDFRHSHSpahkyyLATDPmSGAVFLSDTNSRRVFKVKST 1380
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLDPaTGEFT---EYPLGGGSGPHG------IAVDP-DGNLWFTDNGNNRIGRIDPK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1381 TvvkdlvKNSEVVAGTGDQCLPFddtrcgdggkateatltnprGITVDKFGLIYFVDGT--MIRRVD-QNGIISTLLGsn 1457
Cdd:COG4257 89 T------GEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLDpATGEVTEFPL-- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1458 DLTSARplscdsvmeisqvrlewPTDLAINPmDNSLYVLDNnvvlqisENHQVRIVAGRPMHcqvpgidhflLSKVAIHA 1537
Cdd:COG4257 141 PTGGAG-----------------PYGIAVDP-DGNLWVTDF-------GANAIGRIDPDTGT----------LTEYALPT 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1538 TLESATALAVSHNGVLYIAETDEKKINRIRqvTTSGEISLVAGAPSGCDckndancdcfsgddgyakdaklntPSSLAVC 1617
Cdd:COG4257 186 PGAGPRGLAVDPDGNLWVADTGSGRIGRFD--PKTGTVTEYPLPGGGAR------------------------PYGVAVD 239
|
330
....*....|....*...
gi 568950580 1618 ADGELYVADLGNIRIRFI 1635
Cdd:COG4257 240 GDGRVWFAESGANRIVRF 257
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1421-1632 |
7.83e-07 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 53.44 E-value: 7.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1421 NPRGITVDKFGLIYFVD--GTMIRRVDQNGIISTLLGSndlTSARPLScdsvmeisqvrLEWPTDLAINPmDNSLYVLDn 1498
Cdd:cd14956 108 APRGVAVDADGNLYVADfgNQRIQKFDPDGSFLRQWGG---TGIEPGS-----------FNYPRGVAVDP-DGTLYVAD- 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1499 nvvlqiSENHQVrivagrpmhcQVPGIDHFLLSKVAIHAT----LESATALAVSHNGVLYIAETDEkkiNRIRQVTTSGE 1574
Cdd:cd14956 172 ------TYNDRI----------QVFDNDGAFLRKWGGRGTgpgqFNYPYGIAIDPDGNVFVADFGN---NRIQKFTADGT 232
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 568950580 1575 ISLVAGAPSGcdckndancdcfsgddgyaKDAKLNTPSSLAVCADGELYVADLGNIRI 1632
Cdd:cd14956 233 FLTSWGSPGT-------------------GPGQFKNPWGVVVDADGTVYVADSNNNRV 271
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
2180-2516 |
2.48e-06 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 53.47 E-value: 2.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2180 YRYDDVSGKTEQFGKFGVIY---YDINQIITTAVMT-----HT----------KHFDAYGRMKEVQYEIFRSLmywmTVQ 2241
Cdd:NF041261 367 YRYDDTGRVTEQLNPAGLSYryqYEQDRITITDSLNrrevlHTegegglkrvvKKEHADGSVTRSGYDAAGRL----TAQ 442
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2242 YDNMGRVVKKELKV---------GPYANTTRYSYeyDADGQLQTVSINDKPLWRYSYDLNGNLhLLSPGNSARLTPLRYD 2312
Cdd:NF041261 443 TDAAGRRTEYSLNVvsgditditTPDGRETKFYY--NDGNQLTSVTSPDGLESRREYDEPGRL-VSETSRSGETTRYRYD 519
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2313 lrDRITRLGDVqyKMDEDGFLRQrggdvFEYNSAGLLIkAYNRASGWSVRYRYDGLGRRVSSKSSHSHHLqffYADLTNP 2392
Cdd:NF041261 520 --DPHSELPAT--TTDATGSTKQ-----MTWSRYGQLL-AFTDCSGYQTRYEYDRFGQMTAVHREEGIST---YRRYDNR 586
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 2393 TKVTHLYNHSSSEiTSLYYDLQGHLFAMELSSGDEFYIACDNIGTPLAVFSGtGLMiKQILYTAYGEIYMDTNPNfqiii 2472
Cdd:NF041261 587 GQLTSVKDAQGRE-TRYEYNAAGDLTAVITPDGNRSETQYDAWGKAVSTTQG-GLT-RSMEYDAAGRITTLTNEN----- 658
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 568950580 2473 GYHGG-LYDPLTKLVHMG-------RRDYDvLAGRWTSPDHE----LWKRLSSNSI 2516
Cdd:NF041261 659 GSHSTfLYDALDRLVQQRgfdgrtqRYHYD-LTGKLTQSEDEglvtLWHYDESDRI 713
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1417-1635 |
4.36e-06 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 51.17 E-value: 4.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1417 ATLTNPRGITVDKFGLIYFVD--GTMIRRVD-QNGIIStllgsndltsarplscdsvmEISQVRLEWPTDLAINPmDNSL 1493
Cdd:COG4257 14 APGSGPRDVAVDPDGAVWFTDqgGGRIGRLDpATGEFT--------------------EYPLGGGSGPHGIAVDP-DGNL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1494 YVLD--NNVVLQIS-ENHQVRIVAGrpmhcqvPGIDHFLlskvaihatlesaTALAVSHNGVLYIAETDekkINRIRQVT 1570
Cdd:COG4257 73 WFTDngNNRIGRIDpKTGEITTFAL-------PGGGSNP-------------HGIAFDPDGNLWFTDQG---GNRIGRLD 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1571 T-SGEISLV-----AGAPSGCDCKND---------ANC-DCFSGDDG----YAKDAKLNTPSSLAVCADGELYVADLGNI 1630
Cdd:COG4257 130 PaTGEVTEFplptgGAGPYGIAVDPDgnlwvtdfgANAiGRIDPDTGtlteYALPTPGAGPRGLAVDPDGNLWVADTGSG 209
|
....*
gi 568950580 1631 RIRFI 1635
Cdd:COG4257 210 RIGRF 214
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
1339-1639 |
1.07e-05 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 51.39 E-value: 1.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1339 RNKDFRHSHSPAhKY--YLATDPMSGAVFLSDTNSRRVfkvksttVVKDLVKNSEV-VAGTGDQCL---PFDDtrcgdgg 1412
Cdd:PLN02919 556 KDNDPRLLTSPL-KFpgKLAIDLLNNRLFISDSNHNRI-------VVTDLDGNFIVqIGSTGEEGLrdgSFED------- 620
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1413 kateATLTNPRGITVDKFGLIYFVDGT---MIRRVD-QNGIISTLLGS----NDLTSARPLScdsvmeiSQVrLEWPTDL 1484
Cdd:PLN02919 621 ----ATFNRPQGLAYNAKKNLLYVADTenhALREIDfVNETVRTLAGNgtkgSDYQGGKKGT-------SQV-LNSPWDV 688
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1485 AINPMDNSLYV------------LDNNVVLQISENHQVRIVAGR----PMHCQVPGI------DHFLLSK---------- 1532
Cdd:PLN02919 689 CFEPVNEKVYIamagqhqiweynISDGVTRVFSGDGYERNLNGSsgtsTSFAQPSGIslspdlKELYIADsesssirald 768
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1533 ----------------------------VAIHATLESATALAVSHNGVLYIAETDEKKINRIRQVTtsGEISLVAGAPSG 1584
Cdd:PLN02919 769 lktggsrllaggdptfsdnlfkfgdhdgVGSEVLLQHPLGVLCAKDGQIYVADSYNHKIKKLDPAT--KRVTTLAGTGKA 846
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 568950580 1585 cdckndancdcfSGDDGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFIRKNK 1639
Cdd:PLN02919 847 ------------GFKDGKALKAQLSEPAGLALGENGRLFVADTNNSLIRYLDLNK 889
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1422-1729 |
3.32e-05 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 48.42 E-value: 3.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1422 PRGITVDKFGLIYFVD--GTMIRRVDQNGIISTLLGSNDltsarplscdsvmeISQVRLEWPTDLAINPMDNsLYVLDnn 1499
Cdd:cd14957 20 PRGIAVDSAGNIYVADtgNNRIQVFTSSGVYSYSIGSGG--------------TGSGQFNSPYGIAVDSNGN-IYVAD-- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1500 vvlqiSENHQVRIvagrpmhcqvpgidhFLLSKVAIHA---------TLESATALAVSHNGVLYIAETDEkkiNRIrQVT 1570
Cdd:cd14957 83 -----TDNNRIQV---------------FNSSGVYQYSigtggsgdgQFNGPYGIAVDSNGNIYVADTGN---HRI-QVF 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1571 TSgeislvAGAPsgcdckndancdCFSGDDGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRfirknkpflntqnmyel 1650
Cdd:cd14957 139 TS------SGTF------------SYSIGSGGTGPGQFNGPQGIAVDSDGNIYVADTGNHRIQ----------------- 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1651 sspidqelyLFDTSGKHLYT-QSLPTGDYLYNFTY----TGDGDItHITDNNGNMVNVrRDSTGmplwlvvpdgqVYWVT 1725
Cdd:cd14957 184 ---------VFTSSGTFQYTfGSSGSGPGQFSDPYgiavDSDGNI-YVADTGNHRIQV-FTSSG-----------AYQYS 241
|
....
gi 568950580 1726 MGTN 1729
Cdd:cd14957 242 IGTS 245
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1411-1632 |
4.05e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 48.05 E-value: 4.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1411 GGKATEA-TLTNPRGITVDKFGLIYFVDGT--MIRRVDQNGIISTLLGSNdltSARPLSCDSvmeisqvrlewPTDLAIN 1487
Cdd:cd14956 50 GTTGDGPgQFGRPRGLAVDKDGWLYVADYWgdRIQVFTLTGELQTIGGSS---GSGPGQFNA-----------PRGVAVD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1488 PmDNSLYVLD--NNVVLQISENHQ-VRIVAGRPmhcQVPGidHFLlskvaihatleSATALAVSHNGVLYIAETdekKIN 1564
Cdd:cd14956 116 A-DGNLYVADfgNQRIQKFDPDGSfLRQWGGTG---IEPG--SFN-----------YPRGVAVDPDGTLYVADT---YND 175
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568950580 1565 RIRQVTTSGEISLVAGAPSGcdckndancdcFSGDdgyakdakLNTPSSLAVCADGELYVADLGNIRI 1632
Cdd:cd14956 176 RIQVFDNDGAFLRKWGGRGT-----------GPGQ--------FNYPYGIAIDPDGNVFVADFGNNRI 224
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
818-861 |
4.56e-05 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 43.00 E-value: 4.56e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 568950580 818 CEDGWMGAACDqRACHPRCAE--HGTC-RDGKCECSPGWNGEHCTIA 861
Cdd:pfam01414 1 CDENYYGSTCS-KFCRPRDDKfgHYTCdANGNKVCLPGWTGPYCDKP 46
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1304-1445 |
5.77e-05 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 47.71 E-value: 5.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1304 PVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILEMRNKDFRhshsPahkYYLATDPmSGAVFLSDTNSRRVFKVKSTT 1381
Cdd:COG4257 147 PYGIAVDPDGNLWVTDFgaNAIGRIDPDTGTLTEYALPTPGAG----P---RGLAVDP-DGNLWVADTGSGRIGRFDPKT 218
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1382 vvkdlvknsevvagtgdqclpfddtrcgdgGKATEATLTN----PRGITVDKFGLIYFVDGT--MIRRVD 1445
Cdd:COG4257 219 ------------------------------GTVTEYPLPGggarPYGVAVDGDGRVWFAESGanRIVRFD 258
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1575-1635 |
6.52e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 47.91 E-value: 6.52e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568950580 1575 ISLVAGAPSGcdckndancdcfSGDDGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFI 1635
Cdd:cd14953 1 VSTVAGSGTA------------GFSGGGGTAARFNSPSGVAVDAAGNLYVADRGNHRIRKI 49
|
|
| YD_repeat_2x |
TIGR01643 |
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ... |
1748-1788 |
2.88e-04 |
|
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.
Pssm-ID: 273728 [Multi-domain] Cd Length: 42 Bit Score: 40.65 E-value: 2.88e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 568950580 1748 HGNSGLLATKSNENGWTTFYEYDSFGRLTNVTFPTGQVSSF 1788
Cdd:TIGR01643 1 YDAAGRLTGSTDADGTTTRYTYDAAGRLVEITDADGGSTRY 41
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1546-1636 |
3.36e-04 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 45.65 E-value: 3.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1546 AVSHNGVLYIAETdekKINRIRQV-TTSGEISLVAGapsgcdckndancdcfSGDDGYA-KDAKLNTPSSLAVCADGELY 1623
Cdd:cd14951 202 AALPDGSVYVADT---YNHKIKRVdPATGEVSTLAG----------------TGKAGYKdLEAQFSEPSGLVVDGDGRLY 262
|
90
....*....|...
gi 568950580 1624 VADLGNIRIRFIR 1636
Cdd:cd14951 263 VADTNNHRIRRLD 275
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1752-1784 |
5.90e-04 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 39.50 E-value: 5.90e-04
10 20 30
....*....|....*....|....*....|...
gi 568950580 1752 GLLATKSNENGWTTFYEYDSFGRLTNVTFPTGQ 1784
Cdd:pfam05593 5 GRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
|
|
| Keratin_B2 |
pfam01500 |
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ... |
699-847 |
1.30e-03 |
|
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.
Pssm-ID: 366678 [Multi-domain] Cd Length: 161 Bit Score: 42.09 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 699 TNQCIDVACSSHGTCimGTCICNPGYKGESCEEVDCMDPTCS----SRGVCVRGECHCSVgwgGTNCETPraTCLDQCS- 773
Cdd:pfam01500 6 TSFCGFPTCSTGGTC--GSGCCQPCCCQSSCCRPSCCQTSCCqpttFQSSCCRPTCQPCC---QTSCCQP--TCCQTSSc 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 774 -------GHGTfLPDTGLCNCDPSWTGHDCSIEICAADCGGHGVCVGGTCrCEDGWMGAACdqraCHPRCAEHGTCRDGK 846
Cdd:pfam01500 79 qtgcggiGYGQ-EGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTC-CQLHHAQASC----CRPSYCGQSCCRPAC 152
|
.
gi 568950580 847 C 847
Cdd:pfam01500 153 C 153
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1300-1558 |
1.42e-03 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 43.05 E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1300 KLLAPVALTCGSDGSLYVGDFnYIRRI--F-PSGNVTNILEmRNKDFRHSHSPAHkyyLATDpmSGAVFLSDTNSRRVfk 1376
Cdd:cd14963 54 EFKYPYGIAVDSDGNIYVADL-YNGRIqvFdPDGKFLKYFP-EKKDRVKLISPAG---LAID--DGKLYVSDVKKHKV-- 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1377 vksttVVKDLvknsevvagTGDQCLPFddtrcGDGGKAtEATLTNPRGITVDKFGLIYFVDgTMIRRV---DQNG-IIST 1452
Cdd:cd14963 125 -----IVFDL---------EGKLLLEF-----GKPGSE-PGELSYPNGIAVDEDGNIYVAD-SGNGRIqvfDKNGkFIKE 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1453 LLGSNDLTSArplscdsvmeisqvrLEWPTDLAINPmDNSLYVLDN--NVVLQISENHQVRIVAGRpmhcqvPGIDhfll 1530
Cdd:cd14963 184 LNGSPDGKSG---------------FVNPRGIAVDP-DGNLYVVDNlsHRVYVFDEQGKELFTFGG------RGKD---- 237
|
250 260
....*....|....*....|....*...
gi 568950580 1531 skvaiHATLESATALAVSHNGVLYIAET 1558
Cdd:cd14963 238 -----DGQFNLPNGLFIDDDGRLYVTDR 260
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1299-1383 |
1.90e-03 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 42.70 E-value: 1.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1299 NKLLAPVALTCGSDGSLYVGDF--NYIRRIFP-SGNVTNilemrnkdFRHSHSPAHKYYLATDPmSGAVFLSDTNSRRVF 1375
Cdd:COG4257 185 TPGAGPRGLAVDPDGNLWVADTgsGRIGRFDPkTGTVTE--------YPLPGGGARPYGVAVDG-DGRVWFAESGANRIV 255
|
....*...
gi 568950580 1376 KVKSTTVV 1383
Cdd:COG4257 256 RFDPDTEL 263
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1545-1731 |
2.12e-03 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 42.64 E-value: 2.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1545 LAVSHNGVLYIAETDEkkiNRIRQVTTSGEISLVAGapsgcdckndancdcfSGDDGyakDAKLNTPSSLAVCADGELYV 1624
Cdd:cd14957 23 IAVDSAGNIYVADTGN---NRIQVFTSSGVYSYSIG----------------SGGTG---SGQFNSPYGIAVDSNGNIYV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1625 ADLGNIRIRfirknkpFLNTQNMYElsspidqelYLFDTSGkhlytQSLPTGDYLYNFTYTGDGDItHITDNNGNMVNVr 1704
Cdd:cd14957 81 ADTDNNRIQ-------VFNSSGVYQ---------YSIGTGG-----SGDGQFNGPYGIAVDSNGNI-YVADTGNHRIQV- 137
|
170 180
....*....|....*....|....*..
gi 568950580 1705 RDSTGmplwlvvpdgqVYWVTMGTNSA 1731
Cdd:cd14957 138 FTSSG-----------TFSYSIGSGGT 153
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1412-1514 |
3.61e-03 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 42.18 E-value: 3.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1412 GKATEATLTNPRGITVDKFGLIYFVDgTM---IRRVD-QNGIISTLLGSNDLTSArplscdsvmeISQVRLEWPTDLAIN 1487
Cdd:cd14951 188 GPGAEALLQHPLGVAALPDGSVYVAD-TYnhkIKRVDpATGEVSTLAGTGKAGYK----------DLEAQFSEPSGLVVD 256
|
90 100
....*....|....*....|....*..
gi 568950580 1488 PmDNSLYVLDNNvvlqiseNHQVRIVA 1514
Cdd:cd14951 257 G-DGRLYVADTN-------NHRIRRLD 275
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
836-858 |
3.89e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.94 E-value: 3.89e-03
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
707-730 |
3.92e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 3.92e-03
10 20
....*....|....*....|....*...
gi 568950580 707 CSSHGTCIMG----TCICNPGYKGESCE 730
Cdd:cd00054 11 CQNGGTCVNTvgsyRCSCPPGYTGRNCE 38
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1304-1505 |
5.21e-03 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 41.42 E-value: 5.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1304 PVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILemrnkDFRHSHSPahkYYLATDPmSGAVFLSDTNSRRVFKVkstt 1381
Cdd:cd14952 96 PTGVAVDAAGNVYVADTgnNRVLKLAAGSNTQTVL-----PFTGLSNP---DGVAVDG-AGNVYVTDTGNNRVLKL---- 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950580 1382 vvkdlvknsevVAGTGDQC-LPFDDtrcgdggkateatLTNPRGITVDKFGLIYFVDGtmirrvDQNGIISTLLGSNDLT 1460
Cdd:cd14952 163 -----------AAGSTTQTvLPFTG-------------LNSPSGVAVDTAGNVYVTDH------GNNRVLKLAAGSTTPT 212
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 568950580 1461 sARPLScdsvmeisqvRLEWPTDLAINPmDNSLYVLD--NNVVLQIS 1505
Cdd:cd14952 213 -VLPFT----------GLNGPLGVAVDA-AGNVYVADrgNDRVVKLP 247
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
706-729 |
6.48e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.17 E-value: 6.48e-03
10 20
....*....|....*....|....*.
gi 568950580 706 ACSSHGTCIM--GTCICNPGYKGESC 729
Cdd:pfam07974 1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
2343-2372 |
9.37e-03 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 36.04 E-value: 9.37e-03
10 20 30
....*....|....*....|....*....|
gi 568950580 2343 YNSAGLLIKAYNrASGWSVRYRYDGLGRRV 2372
Cdd:pfam05593 1 YDAAGRLTSVTD-PDGRVTTYTYDAAGRLT 29
|
|
| |
