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Conserved domains on  [gi|568940088|ref|XP_006505325|]
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A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GON pfam08685
GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain ...
 1674-1872 4.96e-111

GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.


:

Pssm-ID: 462559  Cd Length: 200  Bit Score: 350.76  E-value: 4.96e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088  1674 PQNCKEVKKLNSASVDGEYFLAVRGKPLKVFCAGMNSDYPKEYVTLAHGDSENFSEVYGHRLHNPTECPYNGSRRDDCHC 1753
Cdd:pfam08685    1 PRSCKEIQSRSGVRKDGEYTLNVRGRNVRIYCHGMNTSSPKEYLTLPSGPQENYSEVYGYRLKNPNECPFNGSRRDDCAC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088  1754 RKDYTA-AGFSSFQKIRLDLTSMQIITTDLEFARTSEGHPVPFATAGDCYSAAKCPQGRFSINLYGTGLSLTESARWTSQ 1832
Cdd:pfam08685   81 RQDYPAnAGTTTFSKVRLDLTSLRIITNDFTFARTIRGKPVPFGTAGDCYSAAKCPQGRFSINLTGTGLRVSPDTKWVSQ 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 568940088  1833 GNYAVSDIKKSPDGTRVVGKCGGYCGKCTPSSGTGLEVRV 1872
Cdd:pfam08685  161 GNYAVSKIHRSQDGTKVRGRCGGYCGKCTPSPGTGLLLDV 200
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 293-496 1.20e-109

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


:

Pssm-ID: 239801  Cd Length: 207  Bit Score: 347.30  E-value: 1.20e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088  293 RFVEVMVVADHRMV-LYHGANLQHYILTLMSIVASIYKDSSIGNLINIVIVNLVVIHNEQEGPYINFNAQTTLKNFCQWQ 371
Cdd:cd04273     1 RYVETLVVADSKMVeFHHGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLLISGNAQKSLKSFCRWQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088  372 HS---KNYLGGIQHDTAVLVTREDICRAQDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDS- 447
Cdd:cd04273    81 KKlnpPNDSDPEHHDHAILLTRQDICRSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGDg 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 568940088  448 NKCKEEGvkSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLL 496
Cdd:cd04273   161 NSCGPEG--KDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGDGNCLL 207
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 49-207 6.69e-37

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


:

Pssm-ID: 460254  Cd Length: 128  Bit Score: 135.90  E-value: 6.69e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088    49 EIASPIRVNPlgepfptnvhfKRRRRSINSASDPWPafasssssstssQEHYRLSAFGQQFLFNLTAHTGFIAPLFTVTL 128
Cdd:pfam01562    1 EVVIPVRLDP-----------SRRRRSLASESTYLD------------TLSYRLAAFGKKFHLHLTPNRLLLAPGFTVTY 57

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568940088   129 LGEPGVNQTKLYSEEEmelrHCFYKGHVNTKSEHTAVISLCSGMMGTFRSHDGDYFIEPLQSvdeqEDEEEQNKPHIIY 207
Cdd:pfam01562   58 YLDGGTGVESPPVQTD----HCYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEYLIEPLEK----YSREEGGHPHVVY 128
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 754-871 1.09e-35

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 131.93  E-value: 1.09e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088   754 TVAGTFNTVH-YGYNTVVRIPAGATSIDVRQHSFSGkseddNYLALSNSKGEFLLNGDFVVSMSKREVRVGSAVIEYSGS 832
Cdd:pfam05986    1 TVSGSFTEGRaKGYVTFVTIPAGATHIHIVNRKPSF-----THLAVKNVQGKYILNGKGSISLNPTYPSLLGTVLEYRRS 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 568940088   833 DNVVERLNCTDRIEEELLLQVLSV-GKLYNPDVRYSFNIP 871
Cdd:pfam05986   76 LPALEELHAPGPTQEDLEIQVLRQyGKGTNPGITYEYFIP 115
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 511-578 6.56e-19

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


:

Pssm-ID: 465496  Cd Length: 68  Bit Score: 82.39  E-value: 6.56e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088   511 PGLLYNVNKQCELIFGPGSQVCPYMMQ--CRRLWCNNVDGahKGCRTQHTPWADGTECEPGKHCKFGFCV 578
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTFCPNGDEdvCSKLWCSNPGG--STCTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1111-1165 7.57e-18

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 79.03  E-value: 7.57e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088  1111 WQAGPWGQCSVTCGQGYQLRAVKCIMGTYMSVVDDNDCNAATRPTDTQDCELASC 1165
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1497-1550 4.87e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 68.25  E-value: 4.87e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088  1497 WKAGAWSQCTKTCGEGSRYRQVVCVAE-DQSEVHSTHCDSDQRPPDRESCSLQPC 1550
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKgGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1382-1435 4.01e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 65.55  E-value: 4.01e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088  1382 WAYGSWGECTKLCGGGMRTRLVVCQRANGDR-FPDLSCEVLDKPTDREQCNTHAC 1435
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSiVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1328-1379 3.31e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.86  E-value: 3.31e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088  1328 WRTGPWGACSSTCAGGSQRRVVVCQDENG---YTANDCVERIKPDEQRACESGPC 1379
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgsiVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1619-1667 1.87e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 60.93  E-value: 1.87e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568940088  1619 WRVGNWGSCSVSCGIGVMHRSVQC---LTNEDQPSHLCPTDTKPEERKACRN 1667
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkGGGSIVPDSECSAQKKPPETQSCNL 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1001-1053 3.56e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.77  E-value: 3.56e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088  1001 WRYSAWTECSRSCDGGTQRRRAICVNTR-NDVLDDSKCTHQEK-VVVQSCNEFSC 1053
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGgGSIVPDSECSAQKKpPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1056-1108 4.96e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.39  E-value: 4.96e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088  1056 WKTGDWSECLVTCGKGHKHRQVWCQ--FGEDRLSDRMCDPEAKPEPMQTCQQPEC 1108
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 591-642 9.11e-11

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 58.75  E-value: 9.11e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 568940088    591 WGGWSHFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPC 642
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1242-1295 1.04e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 58.62  E-value: 1.04e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088  1242 WKALDWSSCSVTCGQGKATRQVVCVNYSDH-VIDRSECDPDYIPETDQDCSMSPC 1295
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1186-1239 3.27e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.08  E-value: 3.27e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088  1186 WRFGSWTPCSATCGKGTRMRYVSCRDEDG-SVADESACATLPKPVAKEECSVTPC 1239
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgSIVPDSECSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 648-752 3.79e-10

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 58.95  E-value: 3.79e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088   648 DFREEQCAHFDGKHFNIN-GLLPSVRW---VPKYSGILMkdrCKLFCRVAGNTAYYQLRDRVIDGTPC------GQDTND 717
Cdd:pfam19236    4 EFMSQQCARTDGQPLRSSpGGASFYHWgaaVPHSQGDAL---CRHMCRAIGESFIMKRGDSFLDGTRCmpsgprEDGTLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 568940088   718 ICVQGLCRQAGCDHILNSKARKDKCGICGGDNSSC 752
Cdd:pfam19236   81 LCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1441-1484 1.55e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 55.15  E-value: 1.55e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 568940088  1441 WSTGPWSSCSVSCGRGHKHRNVYCLAKDGSHLESD-NCKHLPKPH 1484
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDsECSAQKKPP 45
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1554-1613 4.68e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.30  E-value: 4.68e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568940088  1554 WITGEWSECSVTCGKGYRQRLVSCSEIYTGKENYEYsyqttvNCPGAQ-PPSVHPCYLRDC 1613
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDS------ECSAQKkPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 939-993 5.08e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 45.52  E-value: 5.08e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088   939 WHVASKSECSAQCGLGYRTLDIHCAKYSRMdgktEKVDDSFCSSQPRPSNQEKCS 993
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGG----SIVPDSECSAQKKPPETQSCN 51
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 885-931 1.22e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 44.37  E-value: 1.22e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 568940088   885 GPWQACSKPC-QGERRRKLVCTRESDQLTVSDQRCDRLPQPgPVTEAC 931
Cdd:pfam19030    4 GPWGECSVTCgGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSC 50
 
Name Accession Description Interval E-value
GON pfam08685
GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain ...
 1674-1872 4.96e-111

GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.


Pssm-ID: 462559  Cd Length: 200  Bit Score: 350.76  E-value: 4.96e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088  1674 PQNCKEVKKLNSASVDGEYFLAVRGKPLKVFCAGMNSDYPKEYVTLAHGDSENFSEVYGHRLHNPTECPYNGSRRDDCHC 1753
Cdd:pfam08685    1 PRSCKEIQSRSGVRKDGEYTLNVRGRNVRIYCHGMNTSSPKEYLTLPSGPQENYSEVYGYRLKNPNECPFNGSRRDDCAC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088  1754 RKDYTA-AGFSSFQKIRLDLTSMQIITTDLEFARTSEGHPVPFATAGDCYSAAKCPQGRFSINLYGTGLSLTESARWTSQ 1832
Cdd:pfam08685   81 RQDYPAnAGTTTFSKVRLDLTSLRIITNDFTFARTIRGKPVPFGTAGDCYSAAKCPQGRFSINLTGTGLRVSPDTKWVSQ 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 568940088  1833 GNYAVSDIKKSPDGTRVVGKCGGYCGKCTPSSGTGLEVRV 1872
Cdd:pfam08685  161 GNYAVSKIHRSQDGTKVRGRCGGYCGKCTPSPGTGLLLDV 200
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 293-496 1.20e-109

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 347.30  E-value: 1.20e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088  293 RFVEVMVVADHRMV-LYHGANLQHYILTLMSIVASIYKDSSIGNLINIVIVNLVVIHNEQEGPYINFNAQTTLKNFCQWQ 371
Cdd:cd04273     1 RYVETLVVADSKMVeFHHGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLLISGNAQKSLKSFCRWQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088  372 HS---KNYLGGIQHDTAVLVTREDICRAQDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDS- 447
Cdd:cd04273    81 KKlnpPNDSDPEHHDHAILLTRQDICRSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGDg 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 568940088  448 NKCKEEGvkSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLL 496
Cdd:cd04273   161 NSCGPEG--KDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGDGNCLL 207
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 49-207 6.69e-37

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


Pssm-ID: 460254  Cd Length: 128  Bit Score: 135.90  E-value: 6.69e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088    49 EIASPIRVNPlgepfptnvhfKRRRRSINSASDPWPafasssssstssQEHYRLSAFGQQFLFNLTAHTGFIAPLFTVTL 128
Cdd:pfam01562    1 EVVIPVRLDP-----------SRRRRSLASESTYLD------------TLSYRLAAFGKKFHLHLTPNRLLLAPGFTVTY 57

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568940088   129 LGEPGVNQTKLYSEEEmelrHCFYKGHVNTKSEHTAVISLCSGMMGTFRSHDGDYFIEPLQSvdeqEDEEEQNKPHIIY 207
Cdd:pfam01562   58 YLDGGTGVESPPVQTD----HCYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEYLIEPLEK----YSREEGGHPHVVY 128
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 754-871 1.09e-35

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 131.93  E-value: 1.09e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088   754 TVAGTFNTVH-YGYNTVVRIPAGATSIDVRQHSFSGkseddNYLALSNSKGEFLLNGDFVVSMSKREVRVGSAVIEYSGS 832
Cdd:pfam05986    1 TVSGSFTEGRaKGYVTFVTIPAGATHIHIVNRKPSF-----THLAVKNVQGKYILNGKGSISLNPTYPSLLGTVLEYRRS 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 568940088   833 DNVVERLNCTDRIEEELLLQVLSV-GKLYNPDVRYSFNIP 871
Cdd:pfam05986   76 LPALEELHAPGPTQEDLEIQVLRQyGKGTNPGITYEYFIP 115
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 293-499 5.31e-33

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 127.42  E-value: 5.31e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088   293 RFVEVMVVADHRMVLYHGANLQH---YILTLMSIVASIYKDssignlINI-VIVNLVVIHNEQEGPYINFNAQTTLKNFC 368
Cdd:pfam01421    1 KYIELFIVVDKQLFQKMGSDTTVvrqRVFQVVNLVNSIYKE------LNIrVVLVGLEIWTDEDKIDVSGDANDTLRNFL 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088   369 QWQHSknYLGG-IQHDTAVLVTREDIcraqdKCDTLGLAELGTICDPYRSCSISEDSGLST---AFTIAHELGHVFNMPH 444
Cdd:pfam01421   75 KWRQE--YLKKrKPHDVAQLLSGVEF-----GGTTVGAAYVGGMCSLEYSGGVNEDHSKNLesfAVTMAHELGHNLGMQH 147

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 568940088   445 DDSN---KCKEEGVkspqHVMAPTLNfYTNPWMWSKCSRKYITEFLDTGYGECLLNEP 499
Cdd:pfam01421  148 DDFNggcKCPPGGG----CIMNPSAG-SSFPRKFSNCSQEDFEQFLTKQKGACLFNKP 200
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 511-578 6.56e-19

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 82.39  E-value: 6.56e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088   511 PGLLYNVNKQCELIFGPGSQVCPYMMQ--CRRLWCNNVDGahKGCRTQHTPWADGTECEPGKHCKFGFCV 578
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTFCPNGDEdvCSKLWCSNPGG--STCTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1111-1165 7.57e-18

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 79.03  E-value: 7.57e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088  1111 WQAGPWGQCSVTCGQGYQLRAVKCIMGTYMSVVDDNDCNAATRPTDTQDCELASC 1165
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1497-1550 4.87e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 68.25  E-value: 4.87e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088  1497 WKAGAWSQCTKTCGEGSRYRQVVCVAE-DQSEVHSTHCDSDQRPPDRESCSLQPC 1550
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKgGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1382-1435 4.01e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 65.55  E-value: 4.01e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088  1382 WAYGSWGECTKLCGGGMRTRLVVCQRANGDR-FPDLSCEVLDKPTDREQCNTHAC 1435
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSiVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1328-1379 3.31e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.86  E-value: 3.31e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088  1328 WRTGPWGACSSTCAGGSQRRVVVCQDENG---YTANDCVERIKPDEQRACESGPC 1379
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgsiVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1619-1667 1.87e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 60.93  E-value: 1.87e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568940088  1619 WRVGNWGSCSVSCGIGVMHRSVQC---LTNEDQPSHLCPTDTKPEERKACRN 1667
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkGGGSIVPDSECSAQKKPPETQSCNL 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1001-1053 3.56e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.77  E-value: 3.56e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088  1001 WRYSAWTECSRSCDGGTQRRRAICVNTR-NDVLDDSKCTHQEK-VVVQSCNEFSC 1053
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGgGSIVPDSECSAQKKpPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1056-1108 4.96e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.39  E-value: 4.96e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088  1056 WKTGDWSECLVTCGKGHKHRQVWCQ--FGEDRLSDRMCDPEAKPEPMQTCQQPEC 1108
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 591-642 9.11e-11

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 58.75  E-value: 9.11e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 568940088    591 WGGWSHFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPC 642
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1242-1295 1.04e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 58.62  E-value: 1.04e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088  1242 WKALDWSSCSVTCGQGKATRQVVCVNYSDH-VIDRSECDPDYIPETDQDCSMSPC 1295
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1186-1239 3.27e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.08  E-value: 3.27e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088  1186 WRFGSWTPCSATCGKGTRMRYVSCRDEDG-SVADESACATLPKPVAKEECSVTPC 1239
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgSIVPDSECSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 648-752 3.79e-10

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 58.95  E-value: 3.79e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088   648 DFREEQCAHFDGKHFNIN-GLLPSVRW---VPKYSGILMkdrCKLFCRVAGNTAYYQLRDRVIDGTPC------GQDTND 717
Cdd:pfam19236    4 EFMSQQCARTDGQPLRSSpGGASFYHWgaaVPHSQGDAL---CRHMCRAIGESFIMKRGDSFLDGTRCmpsgprEDGTLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 568940088   718 ICVQGLCRQAGCDHILNSKARKDKCGICGGDNSSC 752
Cdd:pfam19236   81 LCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1441-1484 1.55e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 55.15  E-value: 1.55e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 568940088  1441 WSTGPWSSCSVSCGRGHKHRNVYCLAKDGSHLESD-NCKHLPKPH 1484
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDsECSAQKKPP 45
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1554-1613 4.68e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.30  E-value: 4.68e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568940088  1554 WITGEWSECSVTCGKGYRQRLVSCSEIYTGKENYEYsyqttvNCPGAQ-PPSVHPCYLRDC 1613
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDS------ECSAQKkPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 939-993 5.08e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 45.52  E-value: 5.08e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088   939 WHVASKSECSAQCGLGYRTLDIHCAKYSRMdgktEKVDDSFCSSQPRPSNQEKCS 993
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGG----SIVPDSECSAQKKPPETQSCN 51
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 885-931 1.22e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 44.37  E-value: 1.22e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 568940088   885 GPWQACSKPC-QGERRRKLVCTRESDQLTVSDQRCDRLPQPgPVTEAC 931
Cdd:pfam19030    4 GPWGECSVTCgGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSC 50
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 592-642 1.22e-05

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 44.19  E-value: 1.22e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 568940088   592 GGWSHFGTCSRTCGGGIKTAIRECNRPePKNGGKYCvGRRMKFKSCNTEPC 642
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1239-1296 1.94e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 43.73  E-value: 1.94e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 568940088   1239 CGQWKalDWSSCSVTCGQGKATRQVVCVNYSDHViDRSECDPDYiPETdQDCSMSPCP 1296
Cdd:smart00209    1 WSEWS--EWSPCSVTCGGGVQTRTRSCCSPPPQN-GGGPCTGED-VET-RACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1001-1054 3.04e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.96  E-value: 3.04e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 568940088   1001 WRYSAWTECSRSCDGGTQRRRAICVNTRNDVlDDSKCTHQeKVVVQSCNEFSCP 1054
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQN-GGGPCTGE-DVETRACNEQPCP 53
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 1199-1313 3.74e-05

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 48.42  E-value: 3.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088 1199 GKGTRMRY----VSCRDEDG-----SVADESACATLPKPVAKEECS----VTPCGQWKalDWSSCSVTCGQGKATRQ--V 1263
Cdd:PTZ00441  187 GQGINHQFnrllAGCRPREGkckfySDADWEEAKNLIKPFIAKVCTeverTASCGPWD--EWTPCSVTCGKGTHSRSrpI 264

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 568940088 1264 VCVNYSDHVIdrSECDPDyipetdqDCSMSPCPQWTGLAHPFQNEDFRPR 1313
Cdd:PTZ00441  265 LHEGCTTHMV--EECEEE-------ECPVEPEPLPVPAPVPPTPEDDNPR 305
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1382-1436 6.55e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.19  E-value: 6.55e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088   1382 WAYGSWGECTKLCGGGMRTRLVVCQRANGdRFPDLSCEVLDkpTDREQCNTHACP 1436
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPP-QNGGGPCTGED--VETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1186-1239 7.23e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.19  E-value: 7.23e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 568940088   1186 WRFGSWTPCSATCGKGTRMRYVSCRDEDGSVaDESACATLPKpvAKEECSVTPC 1239
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQN-GGGPCTGEDV--ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1500-1551 1.36e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.42  E-value: 1.36e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 568940088   1500 GAWSQCTKTCGEGSRYRQVVCVAeDQSEVHSTHCDSDQrpPDRESCSLQPCE 1551
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCS-PPPQNGGGPCTGED--VETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1055-1108 1.47e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.03  E-value: 1.47e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 568940088   1055 HWKTGDWSECLVTCGKGHKHRQVWCQFGEDRLSDRMCdPEAKPEpMQTCQQPEC 1108
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPC-TGEDVE-TRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1441-1483 3.56e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 40.26  E-value: 3.56e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 568940088   1441 WSTGPWSSCSVSCGRGHKHRNVYCLAK---------DGSHLESDNCKHLPKP 1483
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPppqngggpcTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1328-1380 4.00e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.88  E-value: 4.00e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 568940088   1328 WRTGPWGACSSTCAGGSQRRVVVCQDENGYT-ANDCVEriKPDEQRACESGPCP 1380
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNgGGPCTG--EDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1553-1578 9.24e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.11  E-value: 9.24e-04
                            10        20
                    ....*....|....*....|....*.
gi 568940088   1553 VWITGEWSECSVTCGKGYRQRLVSCS 1578
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCC 26
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 1191-1229 2.18e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 43.03  E-value: 2.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 568940088 1191 WTPCSATCGKGTRMR-----YVSCRDEDGSVADESACATLPKPV 1229
Cdd:PTZ00441  246 WTPCSVTCGKGTHSRsrpilHEGCTTHMVEECEEEECPVEPEPL 289
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1114-1166 2.65e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.57  E-value: 2.65e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 568940088   1114 GPWGQCSVTCGQGYQLRAVKCIMGTymSVVDDNDCNAATRptDTQDCELASCH 1166
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPP--PQNGGGPCTGEDV--ETRACNEQPCP 53
 
Name Accession Description Interval E-value
GON pfam08685
GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain ...
 1674-1872 4.96e-111

GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.


Pssm-ID: 462559  Cd Length: 200  Bit Score: 350.76  E-value: 4.96e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088  1674 PQNCKEVKKLNSASVDGEYFLAVRGKPLKVFCAGMNSDYPKEYVTLAHGDSENFSEVYGHRLHNPTECPYNGSRRDDCHC 1753
Cdd:pfam08685    1 PRSCKEIQSRSGVRKDGEYTLNVRGRNVRIYCHGMNTSSPKEYLTLPSGPQENYSEVYGYRLKNPNECPFNGSRRDDCAC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088  1754 RKDYTA-AGFSSFQKIRLDLTSMQIITTDLEFARTSEGHPVPFATAGDCYSAAKCPQGRFSINLYGTGLSLTESARWTSQ 1832
Cdd:pfam08685   81 RQDYPAnAGTTTFSKVRLDLTSLRIITNDFTFARTIRGKPVPFGTAGDCYSAAKCPQGRFSINLTGTGLRVSPDTKWVSQ 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 568940088  1833 GNYAVSDIKKSPDGTRVVGKCGGYCGKCTPSSGTGLEVRV 1872
Cdd:pfam08685  161 GNYAVSKIHRSQDGTKVRGRCGGYCGKCTPSPGTGLLLDV 200
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 293-496 1.20e-109

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 347.30  E-value: 1.20e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088  293 RFVEVMVVADHRMV-LYHGANLQHYILTLMSIVASIYKDSSIGNLINIVIVNLVVIHNEQEGPYINFNAQTTLKNFCQWQ 371
Cdd:cd04273     1 RYVETLVVADSKMVeFHHGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLLISGNAQKSLKSFCRWQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088  372 HS---KNYLGGIQHDTAVLVTREDICRAQDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDS- 447
Cdd:cd04273    81 KKlnpPNDSDPEHHDHAILLTRQDICRSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGDg 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 568940088  448 NKCKEEGvkSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLL 496
Cdd:cd04273   161 NSCGPEG--KDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGDGNCLL 207
ZnMc_ADAM_like cd04267
Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ...
 293-488 4.32e-66

Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ADAM family of metalloproteases contains proteolytic domains from snake venoms, proteases from the mammalian reproductive tract, and the tumor necrosis factor alpha convertase, TACE. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239795  Cd Length: 192  Bit Score: 221.91  E-value: 4.32e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088  293 RFVEVMVVADHRMVLY---HGANLQHYILTLMSIVASIYKDSSIGNLINIVIVNLVVIHNEQEGPYINFNAQTTLKNFCQ 369
Cdd:cd04267     1 REIELVVVADHRMVSYfnsDENILQAYITELINIANSIYRSTNLRLGIRISLEGLQILKGEQFAPPIDSDASNTLNSFSF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088  370 WQHSknylGGIQHDTAVLVTREDIcraqDKCDTLGLAELGTICDPYRSCSISEDSG--LSTAFTIAHELGHVFNMPHDDS 447
Cdd:cd04267    81 WRAE----GPIRHDNAVLLTAQDF----IEGDILGLAYVGSMCNPYSSVGVVEDTGftLLTALTMAHELGHNLGAEHDGG 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 568940088  448 NKCKEEGVKSPQHVMAPTLNFyTNPWMWSKCSRKYITEFLD 488
Cdd:cd04267   153 DELAFECDGGGNYIMAPVDSG-LNSYRFSQCSIGSIREFLD 192
ZnMc_adamalysin_II_like cd04269
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom ...
 293-497 4.73e-39

Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239797 [Multi-domain]  Cd Length: 194  Bit Score: 144.68  E-value: 4.73e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088  293 RFVEVMVVADHRMVLYHGANL---QHYILTLMSIVASIYKDSSIgnliNIVIVNLVVIHNEQegpYINF--NAQTTLKNF 367
Cdd:cd04269     1 KYVELVVVVDNSLYKKYGSNLskvRQRVIEIVNIVDSIYRPLNI----RVVLVGLEIWTDKD---KISVsgDAGETLNRF 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088  368 CQWqHSKNYLGGIQHDTAVLVTREDICRaqdkcDTLGLAELGTICDPYRSCSISEDSG---LSTAFTIAHELGHVFNMPH 444
Cdd:cd04269    74 LDW-KRSNLLPRKPHDNAQLLTGRDFDG-----NTVGLAYVGGMCSPKYSGGVVQDHSrnlLLFAVTMAHELGHNLGMEH 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568940088  445 DDSN-KCKEEGVkspqhVMAPTLNFYTnpWMWSKCSRKYITEFLDTGYGECLLN 497
Cdd:cd04269   148 DDGGcTCGRSTC-----IMAPSPSSLT--DAFSNCSYEDYQKFLSRGGGQCLLN 194
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 49-207 6.69e-37

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


Pssm-ID: 460254  Cd Length: 128  Bit Score: 135.90  E-value: 6.69e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088    49 EIASPIRVNPlgepfptnvhfKRRRRSINSASDPWPafasssssstssQEHYRLSAFGQQFLFNLTAHTGFIAPLFTVTL 128
Cdd:pfam01562    1 EVVIPVRLDP-----------SRRRRSLASESTYLD------------TLSYRLAAFGKKFHLHLTPNRLLLAPGFTVTY 57

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568940088   129 LGEPGVNQTKLYSEEEmelrHCFYKGHVNTKSEHTAVISLCSGMMGTFRSHDGDYFIEPLQSvdeqEDEEEQNKPHIIY 207
Cdd:pfam01562   58 YLDGGTGVESPPVQTD----HCYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEYLIEPLEK----YSREEGGHPHVVY 128
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 754-871 1.09e-35

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 131.93  E-value: 1.09e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088   754 TVAGTFNTVH-YGYNTVVRIPAGATSIDVRQHSFSGkseddNYLALSNSKGEFLLNGDFVVSMSKREVRVGSAVIEYSGS 832
Cdd:pfam05986    1 TVSGSFTEGRaKGYVTFVTIPAGATHIHIVNRKPSF-----THLAVKNVQGKYILNGKGSISLNPTYPSLLGTVLEYRRS 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 568940088   833 DNVVERLNCTDRIEEELLLQVLSV-GKLYNPDVRYSFNIP 871
Cdd:pfam05986   76 LPALEELHAPGPTQEDLEIQVLRQyGKGTNPGITYEYFIP 115
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 293-499 5.31e-33

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 127.42  E-value: 5.31e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088   293 RFVEVMVVADHRMVLYHGANLQH---YILTLMSIVASIYKDssignlINI-VIVNLVVIHNEQEGPYINFNAQTTLKNFC 368
Cdd:pfam01421    1 KYIELFIVVDKQLFQKMGSDTTVvrqRVFQVVNLVNSIYKE------LNIrVVLVGLEIWTDEDKIDVSGDANDTLRNFL 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088   369 QWQHSknYLGG-IQHDTAVLVTREDIcraqdKCDTLGLAELGTICDPYRSCSISEDSGLST---AFTIAHELGHVFNMPH 444
Cdd:pfam01421   75 KWRQE--YLKKrKPHDVAQLLSGVEF-----GGTTVGAAYVGGMCSLEYSGGVNEDHSKNLesfAVTMAHELGHNLGMQH 147

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 568940088   445 DDSN---KCKEEGVkspqHVMAPTLNfYTNPWMWSKCSRKYITEFLDTGYGECLLNEP 499
Cdd:pfam01421  148 DDFNggcKCPPGGG----CIMNPSAG-SSFPRKFSNCSQEDFEQFLTKQKGACLFNKP 200
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 293-487 1.04e-29

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 116.85  E-value: 1.04e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088  293 RFVEVMVVADHRMvlYHGANLQHYILTLMSIVASIYKDSsigNLINIVIVNLVVIHneqegpyinfnaqttlknfcqwqh 372
Cdd:cd00203     1 KVIPYVVVADDRD--VEEENLSAQIQSLILIAMQIWRDY---LNIRFVLVGVEIDK------------------------ 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088  373 sknylggiqHDTAVLVTREDIcraqdKCDTLGLAELGTICDPYRSCSISEDSGLST---AFTIAHELGHVFNMPHDDSNK 449
Cdd:cd00203    52 ---------ADIAILVTRQDF-----DGGTGGWAYLGRVCDSLRGVGVLQDNQSGTkegAQTIAHELGHALGFYHDHDRK 117

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 568940088  450 CKEEGVKS----------PQHVMAPTLNFYT--NPWMWSKCSRKYITEFL 487
Cdd:cd00203   118 DRDDYPTIddtlnaedddYYSVMSYTKGSFSdgQRKDFSQCDIDQINKLY 167
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 511-578 6.56e-19

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 82.39  E-value: 6.56e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088   511 PGLLYNVNKQCELIFGPGSQVCPYMMQ--CRRLWCNNVDGahKGCRTQHTPWADGTECEPGKHCKFGFCV 578
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTFCPNGDEdvCSKLWCSNPGG--STCTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1111-1165 7.57e-18

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 79.03  E-value: 7.57e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088  1111 WQAGPWGQCSVTCGQGYQLRAVKCIMGTYMSVVDDNDCNAATRPTDTQDCELASC 1165
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
ZnMc_salivary_gland_MPs cd04272
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary ...
 294-495 4.01e-14

Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.


Pssm-ID: 239800  Cd Length: 220  Bit Score: 73.54  E-value: 4.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088  294 FVEVMVVADHRMVLYHGANLQ--HYILTLMSIVASIYKDSSIGNlINIVIVNLVVIHNEQEGPYI------NFNAQTTLK 365
Cdd:cd04272     2 YPELFVVVDYDHQSEFFSNEQliRYLAVMVNAANLRYRDLKSPR-IRLLLVGITISKDPDFEPYIhpinygYIDAAETLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088  366 NFCQWQHSKNYLGgiQHDTAVLVTREDICRAQD-KCDT--LGLAELGTICDPYRsCSISEDSGLS--TAFTIAHELGHVF 440
Cdd:cd04272    81 NFNEYVKKKRDYF--NPDVVFLVTGLDMSTYSGgSLQTgtGGYAYVGGACTENR-VAMGEDTPGSyyGVYTMTHELAHLL 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568940088  441 NMPHDDS---NKCK----------EEGvkspqHVMApTLNFYTNPWMWSKCSRKYITEFLDTGYGECL 495
Cdd:cd04272   158 GAPHDGSpppSWVKghpgsldcpwDDG-----YIMS-YVVNGERQYRFSQCSQRQIRNVFRRLGASCL 219
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1497-1550 4.87e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 68.25  E-value: 4.87e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088  1497 WKAGAWSQCTKTCGEGSRYRQVVCVAE-DQSEVHSTHCDSDQRPPDRESCSLQPC 1550
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKgGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1382-1435 4.01e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 65.55  E-value: 4.01e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088  1382 WAYGSWGECTKLCGGGMRTRLVVCQRANGDR-FPDLSCEVLDKPTDREQCNTHAC 1435
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSiVPDSECSAQKKPPETQSCNLKPC 55
Reprolysin_3 pfam13582
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 316-445 1.08e-12

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 463926 [Multi-domain]  Cd Length: 122  Bit Score: 66.62  E-value: 1.08e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088   316 YILTLMSIVASIY-KDSSIG-NLINIVIVNLvvihneQEGPYINFNAQTTLKNFCQWQHskNYLGGIQHDTAVLVTRedi 393
Cdd:pfam13582    2 RIVSLVNRANTIYeRDLGIRlQLAAIIITTS------ADTPYTSSDALEILDELQEVND--TRIGQYGYDLGHLFTG--- 70

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088   394 craQDKCDTLGLAELGTICDPYRSCSISEDS---GLSTAFTIAHELGHVFNMPHD 445
Cdd:pfam13582   71 ---RDGGGGGGIAYVGGVCNSGSKFGVNSGSgpvGDTGADTFAHEIGHNFGLNHT 122
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1328-1379 3.31e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.86  E-value: 3.31e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088  1328 WRTGPWGACSSTCAGGSQRRVVVCQDENG---YTANDCVERIKPDEQRACESGPC 1379
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgsiVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1619-1667 1.87e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 60.93  E-value: 1.87e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568940088  1619 WRVGNWGSCSVSCGIGVMHRSVQC---LTNEDQPSHLCPTDTKPEERKACRN 1667
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkGGGSIVPDSECSAQKKPPETQSCNL 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1001-1053 3.56e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.77  E-value: 3.56e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088  1001 WRYSAWTECSRSCDGGTQRRRAICVNTR-NDVLDDSKCTHQEK-VVVQSCNEFSC 1053
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGgGSIVPDSECSAQKKpPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1056-1108 4.96e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.39  E-value: 4.96e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088  1056 WKTGDWSECLVTCGKGHKHRQVWCQ--FGEDRLSDRMCDPEAKPEPMQTCQQPEC 1108
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 591-642 9.11e-11

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 58.75  E-value: 9.11e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 568940088    591 WGGWSHFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPC 642
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1242-1295 1.04e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 58.62  E-value: 1.04e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088  1242 WKALDWSSCSVTCGQGKATRQVVCVNYSDH-VIDRSECDPDYIPETDQDCSMSPC 1295
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsIVPDSECSAQKKPPETQSCNLKPC 55
Reprolysin_5 pfam13688
Metallo-peptidase family M12;
291-445 1.49e-10

Metallo-peptidase family M12;


Pssm-ID: 372673  Cd Length: 191  Bit Score: 62.44  E-value: 1.49e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088   291 YPRFVEVMVVADHRMVLYHGAN-LQHYILTLMSIVASIYKDSSigNlINIVIVNlVVIHNEQEGPYINF----NAQTTLK 365
Cdd:pfam13688    1 STRTVALLVAADCSYVAAFGGDaAQANIINMVNTASNVYERDF--N-ISLGLVN-LTISDSTCPYTPPAcstgDSSDRLS 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088   366 NFcQWQHSKNylGGIQHDTAVLVTREDicraqdkCDTLGLAELGTICDPYRSCSISEDSG--------LSTAFTIAHELG 437
Cdd:pfam13688   77 EF-QDFSAWR--GTQNDDLAYLFLMTN-------CSGGGLAWLGQLCNSGSAGSVSTRVSgnnvvvstATEWQVFAHEIG 146


                   ....*...
gi 568940088   438 HVFNMPHD 445
Cdd:pfam13688  147 HNFGAVHD 154
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1186-1239 3.27e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.08  E-value: 3.27e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088  1186 WRFGSWTPCSATCGKGTRMRYVSCRDEDG-SVADESACATLPKPVAKEECSVTPC 1239
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgSIVPDSECSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 648-752 3.79e-10

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 58.95  E-value: 3.79e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088   648 DFREEQCAHFDGKHFNIN-GLLPSVRW---VPKYSGILMkdrCKLFCRVAGNTAYYQLRDRVIDGTPC------GQDTND 717
Cdd:pfam19236    4 EFMSQQCARTDGQPLRSSpGGASFYHWgaaVPHSQGDAL---CRHMCRAIGESFIMKRGDSFLDGTRCmpsgprEDGTLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 568940088   718 ICVQGLCRQAGCDHILNSKARKDKCGICGGDNSSC 752
Cdd:pfam19236   81 LCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1441-1484 1.55e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 55.15  E-value: 1.55e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 568940088  1441 WSTGPWSSCSVSCGRGHKHRNVYCLAKDGSHLESD-NCKHLPKPH 1484
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDsECSAQKKPP 45
Reprolysin_2 pfam13574
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 311-487 4.22e-09

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 372637  Cd Length: 193  Bit Score: 58.02  E-value: 4.22e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088   311 ANLQHYILTLMSIVASIYKDSSIGnlINIVIVN---LVVIHNEQEGPYINFNAQTT----LKNFCQWQHSKNYlggiqhD 383
Cdd:pfam13574    1 GNVTENLVNVVNRVNQIYEPDDIN--INGGLVNpgeIPATTSASDSGNNYCNSPTTivrrLNFLSQWRGEQDY------C 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088   384 TAVLVTREDICRAqdkcdTLGLAELGTICDPYRSCsISEDSGLSTAFT-------------IAHELGHVFNMPHD----- 445
Cdd:pfam13574   73 LAHLVTMGTFSGG-----ELGLAYVGQICQKGASS-PKTNTGLSTTTNygsfnyptqewdvVAHEVGHNFGATHDcdgsq 146

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 568940088   446 -DSNKCKEEGVKSP-----QHVMAPT---LNFytnpwMWSKCSRKYITEFL 487
Cdd:pfam13574  147 yASSGCERNAATSVcsangSFIMNPAsksNND-----LFSPCSISLICDVL 192
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1554-1613 4.68e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.30  E-value: 4.68e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568940088  1554 WITGEWSECSVTCGKGYRQRLVSCSEIYTGKENYEYsyqttvNCPGAQ-PPSVHPCYLRDC 1613
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDS------ECSAQKkPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 939-993 5.08e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 45.52  E-value: 5.08e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088   939 WHVASKSECSAQCGLGYRTLDIHCAKYSRMdgktEKVDDSFCSSQPRPSNQEKCS 993
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGG----SIVPDSECSAQKKPPETQSCN 51
ZnMc_TACE_like cd04270
Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha ...
 299-494 6.62e-06

Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.


Pssm-ID: 239798 [Multi-domain]  Cd Length: 244  Bit Score: 49.68  E-value: 6.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088  299 VVADHRMVLYHGANLQ----HYILTLMSIVASIYKDSSIGNLI--NI-VIVNLVVIHNEQE----------GPYINFNAQ 361
Cdd:cd04270     7 LVADHRFYKYMGRGEEettiNYLISHIDRVDDIYRNTDWDGGGfkGIgFQIKRIRIHTTPDevdpgnkfynKSFPNWGVE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088  362 TTLKNFCQWQHSKNYLggiqhdTAVLVTredicrAQDKCD-TLGLAELGT--------ICDPYRSCS----ISEDSGLST 428
Cdd:cd04270    87 KFLVKLLLEQFSDDVC------LAHLFT------YRDFDMgTLGLAYVGSprdnsaggICEKAYYYSngkkKYLNTGLTT 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088  429 AF-------------TIAHELGHVFNMPHD-DSNKCKEEGVKSPQHVMAP--TLNFYTNPWMWSKCSRKYITEFLDTGYG 492
Cdd:cd04270   155 TVnygkrvptkesdlVTAHELGHNFGSPHDpDIAECAPGESQGGNYIMYAraTSGDKENNKKFSPCSKKSISKVLEVKSN 234


                  ..
gi 568940088  493 EC 494
Cdd:cd04270   235 SC 236
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 885-931 1.22e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 44.37  E-value: 1.22e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 568940088   885 GPWQACSKPC-QGERRRKLVCTRESDQLTVSDQRCDRLPQPgPVTEAC 931
Cdd:pfam19030    4 GPWGECSVTCgGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSC 50
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 592-642 1.22e-05

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 44.19  E-value: 1.22e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 568940088   592 GGWSHFGTCSRTCGGGIKTAIRECNRPePKNGGKYCvGRRMKFKSCNTEPC 642
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1239-1296 1.94e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 43.73  E-value: 1.94e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 568940088   1239 CGQWKalDWSSCSVTCGQGKATRQVVCVNYSDHViDRSECDPDYiPETdQDCSMSPCP 1296
Cdd:smart00209    1 WSEWS--EWSPCSVTCGGGVQTRTRSCCSPPPQN-GGGPCTGED-VET-RACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1001-1054 3.04e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.96  E-value: 3.04e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 568940088   1001 WRYSAWTECSRSCDGGTQRRRAICVNTRNDVlDDSKCTHQeKVVVQSCNEFSCP 1054
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQN-GGGPCTGE-DVETRACNEQPCP 53
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 1199-1313 3.74e-05

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 48.42  E-value: 3.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940088 1199 GKGTRMRY----VSCRDEDG-----SVADESACATLPKPVAKEECS----VTPCGQWKalDWSSCSVTCGQGKATRQ--V 1263
Cdd:PTZ00441  187 GQGINHQFnrllAGCRPREGkckfySDADWEEAKNLIKPFIAKVCTeverTASCGPWD--EWTPCSVTCGKGTHSRSrpI 264

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 568940088 1264 VCVNYSDHVIdrSECDPDyipetdqDCSMSPCPQWTGLAHPFQNEDFRPR 1313
Cdd:PTZ00441  265 LHEGCTTHMV--EECEEE-------ECPVEPEPLPVPAPVPPTPEDDNPR 305
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1382-1436 6.55e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.19  E-value: 6.55e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 568940088   1382 WAYGSWGECTKLCGGGMRTRLVVCQRANGdRFPDLSCEVLDkpTDREQCNTHACP 1436
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPP-QNGGGPCTGED--VETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1186-1239 7.23e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.19  E-value: 7.23e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 568940088   1186 WRFGSWTPCSATCGKGTRMRYVSCRDEDGSVaDESACATLPKpvAKEECSVTPC 1239
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQN-GGGPCTGEDV--ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1500-1551 1.36e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.42  E-value: 1.36e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 568940088   1500 GAWSQCTKTCGEGSRYRQVVCVAeDQSEVHSTHCDSDQrpPDRESCSLQPCE 1551
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCS-PPPQNGGGPCTGED--VETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1055-1108 1.47e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.03  E-value: 1.47e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 568940088   1055 HWKTGDWSECLVTCGKGHKHRQVWCQFGEDRLSDRMCdPEAKPEpMQTCQQPEC 1108
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPC-TGEDVE-TRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1441-1483 3.56e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 40.26  E-value: 3.56e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 568940088   1441 WSTGPWSSCSVSCGRGHKHRNVYCLAK---------DGSHLESDNCKHLPKP 1483
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPppqngggpcTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1328-1380 4.00e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.88  E-value: 4.00e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 568940088   1328 WRTGPWGACSSTCAGGSQRRVVVCQDENGYT-ANDCVEriKPDEQRACESGPCP 1380
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNgGGPCTG--EDVETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
1188-1239 9.11e-04

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 38.94  E-value: 9.11e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568940088  1188 FGSWTPCSATCGKGTRMRYVSCrdeDGSVADESACaTLPKpVAKEECSVTPC 1239
Cdd:pfam00090    3 WSPWSPCSVTCGKGIQVRQRTC---KSPFPGGEPC-TGDD-IETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1553-1578 9.24e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.11  E-value: 9.24e-04
                            10        20
                    ....*....|....*....|....*.
gi 568940088   1553 VWITGEWSECSVTCGKGYRQRLVSCS 1578
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCC 26
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 1191-1229 2.18e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 43.03  E-value: 2.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 568940088 1191 WTPCSATCGKGTRMR-----YVSCRDEDGSVADESACATLPKPV 1229
Cdd:PTZ00441  246 WTPCSVTCGKGTHSRsrpilHEGCTTHMVEECEEEECPVEPEPL 289
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1114-1166 2.65e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.57  E-value: 2.65e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 568940088   1114 GPWGQCSVTCGQGYQLRAVKCIMGTymSVVDDNDCNAATRptDTQDCELASCH 1166
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPP--PQNGGGPCTGEDV--ETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
1500-1550 2.72e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 37.40  E-value: 2.72e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 568940088  1500 GAWSQCTKTCGEGSRYRQVVCVAEDQSevhSTHCDSDQRPpdRESCSLQPC 1550
Cdd:pfam00090    4 SPWSPCSVTCGKGIQVRQRTCKSPFPG---GEPCTGDDIE--TQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
1556-1577 3.95e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 37.01  E-value: 3.95e-03
                           10        20
                   ....*....|....*....|..
gi 568940088  1556 TGEWSECSVTCGKGYRQRLVSC 1577
Cdd:pfam00090    3 WSPWSPCSVTCGKGIQVRQRTC 24
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 996-1053 4.70e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 36.87  E-value: 4.70e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 568940088   996 CSTGGWrySAWTECSRSCDGGTQRR-RAICVNTRNdvlDDSKCTHQEKvvVQSCNEFSC 1053
Cdd:pfam19028    1 CVVSEW--SEWSECSVTCGGGVQTRtRTVIVEPQN---GGRPCPELLE--RRPCNLPPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1188-1206 5.78e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 36.49  E-value: 5.78e-03
                           10
                   ....*....|....*....
gi 568940088  1188 FGSWTPCSATCGKGTRMRY 1206
Cdd:pfam19028    6 WSEWSECSVTCGGGVQTRT 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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