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Conserved domains on  [gi|568917448|ref|XP_006499786|]
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cordon-bleu protein-like 1 isoform X20 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Cobl pfam09469
Cordon-bleu ubiquitin-like domain; The Cordon-bleu protein domain is highly conserved among ...
92-168 3.67e-41

Cordon-bleu ubiquitin-like domain; The Cordon-bleu protein domain is highly conserved among vertebrates. The sequence contains three repeated lysine, arginine, and proline-rich regions, the KKRAP motif. The exact function of the protein is unknown but it is thought to be involved in mid-brain neural tube closure. It is expressed specifically in the node. This domain has a ubiquitin-like fold.


:

Pssm-ID: 462810  Cd Length: 79  Bit Score: 145.81  E-value: 3.67e-41
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568917448    92 EKTVRVVINFKKTQKTIVRVSPHAPLQDLAPIICSKCEFDPLHTVLLKDYQAQEPLDLTKSLNDLGLRELYAMDISR 168
Cdd:pfam09469    1 EKTVRLVVNYKKTQKAVVRVSPHVPLQELLPIICSKCEFDPLHVLLLKDYISQEELDLTKSLNDLGIKELYAMDVNR 77
PHA03247 super family cl33720
large tegument protein UL36; Provisional
822-1093 3.85e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.03  E-value: 3.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  822 PPKAPRVTTDTGTIPFAPNLEDInnilESKFRSRASNPQAKPSSfflqMQKRASGHYVTSAAAKSVHTAPGPAPKEPtik 901
Cdd:PHA03247 2556 PPAAPPAAPDRSVPPPRPAPRPS----EPAVTSRARRPDAPPQS----ARPRAPVDDRGDPRGPAPPSPLPPDTHAP--- 2624
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  902 evqRDPQLSPEQHPSSLSErTHSAPLPNISKADDD-------------IIQKPAETSPPPVAPKPMTLraetsPPPVfpK 968
Cdd:PHA03247 2625 ---DPPPPSPSPAANEPDP-HPPPTVPPPERPRDDpapgrvsrprrarRLGRAAQASSPPQRPRRRAA-----RPTV--G 2693
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  969 PMTLPAETSPPPVFPKPMTLPAETSLPLvfpKPMTLRAETSPPPVAAKPVALPGSQGTSLNLKTLKTFGAPRPYSSSGPS 1048
Cdd:PHA03247 2694 SLTSLADPPPPPPTPEPAPHALVSATPL---PPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPA 2770
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 568917448 1049 PFALAVVKRSQSFSKACPESASEGSSALPPAATQDEKTHTVNKPT 1093
Cdd:PHA03247 2771 PPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA 2815
WH2 super family cl41728
Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins; This ...
1139-1164 5.74e-08

Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins; This family contains the Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) as well as thymosin-beta (Tbeta; also called beta-thymosin or betaT) domains that are small, widespread intrinsically disordered actin-binding peptides displaying significant sequence variability and different regulations of actin self-assembly in motile and morphogenetic processes. These WH2/betaT peptides are identified by a central consensus actin-binding motif LKKT/V flanked by variable N-terminal and C-terminal extensions; the betaT shares a more extended and conserved C-terminal half than WH2. These single or repeated domains are found in actin-binding proteins (ABPs) such as the hematopoietic-specific protein WASP, its ubiquitously expressed ortholog neural-WASP (N-WASP), WASP-interacting protein (WAS/WASL-interacting protein family members 1 and 2), and WASP-family verprolin homologous protein (WAVE/SCAR) isoforms: WAVE1, WAVE2, and WAVE3. Also included are the WH2 domains found in inverted formin FH2 domain-containing protein (INF2), Cordon bleu (Cobl) protein, vasodilator-stimulated phosphoprotein (VASP) homology protein and actobindin (found in amoebae). These ABPs are commonly multidomain proteins that contain signaling domains and structurally conserved actin-binding motifs, the most important being the WH2 domain motif through which they bind actin in order to direct the location, rate, and timing for actin assembly in the cell into different structures, such as filopodia, lamellipodia, stress fibers, and focal adhesions. The WH2 domain motif is one of the most abundant actin-binding motifs in Wiskott-Aldrich syndrome proteins (WASPs) where they activate Arp2/3-dependent actin nucleation and branching in response to signals mediated by Rho-family GTPases. The thymosin beta (Tbeta) domains in metazoans act in cells as major actin-sequestering peptides; their complex with monomeric ATP-actin (G-ATP-actin) cannot polymerize at either filament (F-actin) end.


The actual alignment was detected with superfamily member cd21801:

Pssm-ID: 425359  Cd Length: 26  Bit Score: 49.61  E-value: 5.74e-08
                          10        20
                  ....*....|....*....|....*.
gi 568917448 1139 DPEHVRQSLLTAIRSGEAAAKLKRVT 1164
Cdd:cd21801     1 NPEQARQALLEAIRSGEGAARLKKVP 26
RBD super family cl46342
Raf-like Ras-binding domain;
8-74 8.96e-03

Raf-like Ras-binding domain;


The actual alignment was detected with superfamily member pfam02196:

Pssm-ID: 460485  Cd Length: 69  Bit Score: 35.96  E-value: 8.96e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568917448     8 LSVVLPGDILKSTTVHGSKPMMDLLVFLCAQYHLNPSSHTIDLLSAEENLIkfKPNTPIGMLDVEKV 74
Cdd:pfam02196    2 CRVYLPDGQRTVVQVRPGETVRDALSKLCKKRGLNPEACDVYLVGGDKYPL--DLDTDSSTLEGEEV 66
 
Name Accession Description Interval E-value
Cobl pfam09469
Cordon-bleu ubiquitin-like domain; The Cordon-bleu protein domain is highly conserved among ...
92-168 3.67e-41

Cordon-bleu ubiquitin-like domain; The Cordon-bleu protein domain is highly conserved among vertebrates. The sequence contains three repeated lysine, arginine, and proline-rich regions, the KKRAP motif. The exact function of the protein is unknown but it is thought to be involved in mid-brain neural tube closure. It is expressed specifically in the node. This domain has a ubiquitin-like fold.


Pssm-ID: 462810  Cd Length: 79  Bit Score: 145.81  E-value: 3.67e-41
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568917448    92 EKTVRVVINFKKTQKTIVRVSPHAPLQDLAPIICSKCEFDPLHTVLLKDYQAQEPLDLTKSLNDLGLRELYAMDISR 168
Cdd:pfam09469    1 EKTVRLVVNYKKTQKAVVRVSPHVPLQELLPIICSKCEFDPLHVLLLKDYISQEELDLTKSLNDLGIKELYAMDVNR 77
PHA03247 PHA03247
large tegument protein UL36; Provisional
822-1093 3.85e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.03  E-value: 3.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  822 PPKAPRVTTDTGTIPFAPNLEDInnilESKFRSRASNPQAKPSSfflqMQKRASGHYVTSAAAKSVHTAPGPAPKEPtik 901
Cdd:PHA03247 2556 PPAAPPAAPDRSVPPPRPAPRPS----EPAVTSRARRPDAPPQS----ARPRAPVDDRGDPRGPAPPSPLPPDTHAP--- 2624
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  902 evqRDPQLSPEQHPSSLSErTHSAPLPNISKADDD-------------IIQKPAETSPPPVAPKPMTLraetsPPPVfpK 968
Cdd:PHA03247 2625 ---DPPPPSPSPAANEPDP-HPPPTVPPPERPRDDpapgrvsrprrarRLGRAAQASSPPQRPRRRAA-----RPTV--G 2693
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  969 PMTLPAETSPPPVFPKPMTLPAETSLPLvfpKPMTLRAETSPPPVAAKPVALPGSQGTSLNLKTLKTFGAPRPYSSSGPS 1048
Cdd:PHA03247 2694 SLTSLADPPPPPPTPEPAPHALVSATPL---PPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPA 2770
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 568917448 1049 PFALAVVKRSQSFSKACPESASEGSSALPPAATQDEKTHTVNKPT 1093
Cdd:PHA03247 2771 PPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA 2815
WH2_Wc_Cobl cd21801
third Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wc) found in ...
1139-1164 5.74e-08

third Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wc) found in protein Cordon-Bleu (Cobl) and similar proteins; This family contains the third tandem Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2), called Wc, found in protein Cordon-Bleu (Cobl), a potent actin filament nucleator that plays an important role in the reorganization of the actin cytoskeleton. It regulates neuron morphogenesis and increases branching of axons and dendrites. It also modulates dendrite branching in Purkinje cells. Cobl binds to and sequesters actin monomers (G-actin). Cobl contains three tandem WH2 (or W) domains consisting of an N-terminal alpha helix and a C-terminal LRKV motif. The first two WH2 domains have the highest binding affinity for actin. They are functionally active in actin nucleation and polymerization. The model corresponds to the first WH2 domain.


Pssm-ID: 409199  Cd Length: 26  Bit Score: 49.61  E-value: 5.74e-08
                          10        20
                  ....*....|....*....|....*.
gi 568917448 1139 DPEHVRQSLLTAIRSGEAAAKLKRVT 1164
Cdd:cd21801     1 NPEQARQALLEAIRSGEGAARLKKVP 26
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
783-1080 2.26e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 49.00  E-value: 2.26e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448   783 PATSKSSQQPQPDLKPKP--SSGTERHLHRTLSSPTGTETNPPKAPRVTTDTGTIPFApnledinnILESKFRSRASNPQ 860
Cdd:pfam03154  212 PATSQPPNQTQSTAAPHTliQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQP--------SLHGQMPPMPHSLQ 283
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448   861 AKPSsfFLQMQKRASGHYVTSAAAKSvHTAPGPAPKEPTikEVQRDPQLSPEQHPSSLSERTHSAPLPNISKADDDIiqK 940
Cdd:pfam03154  284 TGPS--HMQHPVPPQPFPLTPQSSQS-QVPPGPSPAAPG--QSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHI--K 356
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448   941 PAETSPPPVAPKPmtlRAETSPPPVF-PKPMTLPAETSPPPVFpKPMTLPAETSLPLVFPKPMTLRAETSP-PPVAAKPV 1018
Cdd:pfam03154  357 PPPTTPIPQLPNP---QSHKHPPHLSgPSPFQMNSNLPPPPAL-KPLSSLSTHHPPSAHPPPLQLMPQSQQlPPPPAQPP 432
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568917448  1019 ALPGSQGTSLNLKTLKTFGAPRPYSSSGP---SPFALAVVKRSQSFSKACPESASEGSSALPPAA 1080
Cdd:pfam03154  433 VLTQSQSLPPPAASHPPTSGLHQVPSQSPfpqHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSS 497
BimA_second NF040983
trimeric autotransporter actin-nucleating factor BimA; This HMM describes BimA (Burkholderia ...
941-1021 1.06e-03

trimeric autotransporter actin-nucleating factor BimA; This HMM describes BimA (Burkholderia intracellular motility A), WP_004266405.1-like proteins in Burkholderia mallei or B. pseudomallei. The term BimA has also been used for WP_011205626.1-like homologs that have a very different N-terminal half.


Pssm-ID: 468913 [Multi-domain]  Cd Length: 382  Bit Score: 42.97  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  941 PAETSPPPVAPKPMTLRAETSPPPVFPKPMTLPAETSPPPVFPKPMTLPAETSLPLVFPKPMTLRAETSPPPVaaKPVAL 1020
Cdd:NF040983   86 PNKVPPPPPPPPPPPPPPPTPPPPPPPPPPPPPPSPPPPPPPSPPPSPPPPTTTPPTRTTPSTTTPTPSMHPI--QPTQL 163

                  .
gi 568917448 1021 P 1021
Cdd:NF040983  164 P 164
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
891-1021 2.74e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 41.68  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  891 PGPAPKEPTIKEVQRDPQlsPEQHPSSLSERTHSAPLPNISKADddiIQKPAETSPPPVAPKPMTLRAETSPPPVFPKPM 970
Cdd:NF033839  345 PQLETPKPEVKPQPEKPK--PEVKPQPEKPKPEVKPQPETPKPE---VKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPE 419
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568917448  971 TLPA------ETSPPPVFPKPMTLP-AETSLPLVFPKPMTLRAETSPPPVAAKPVALP 1021
Cdd:NF033839  420 VKPQpekpkpEVKPQPEKPKPEVKPqPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKP 477
BimA_second NF040983
trimeric autotransporter actin-nucleating factor BimA; This HMM describes BimA (Burkholderia ...
938-1023 7.22e-03

trimeric autotransporter actin-nucleating factor BimA; This HMM describes BimA (Burkholderia intracellular motility A), WP_004266405.1-like proteins in Burkholderia mallei or B. pseudomallei. The term BimA has also been used for WP_011205626.1-like homologs that have a very different N-terminal half.


Pssm-ID: 468913 [Multi-domain]  Cd Length: 382  Bit Score: 40.27  E-value: 7.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  938 IQKPAETSPPPVAPKPMTLRAETSPPPVFPKPMTLPAETSPPPVFPKPMTLPAETSLPLVfPKPMTLRAETSPPPVAAKP 1017
Cdd:NF040983   89 VPPPPPPPPPPPPPPPTPPPPPPPPPPPPPPSPPPPPPPSPPPSPPPPTTTPPTRTTPST-TTPTPSMHPIQPTQLPSIP 167

                  ....*.
gi 568917448 1018 VALPGS 1023
Cdd:NF040983  168 NATPTS 173
RBD pfam02196
Raf-like Ras-binding domain;
8-74 8.96e-03

Raf-like Ras-binding domain;


Pssm-ID: 460485  Cd Length: 69  Bit Score: 35.96  E-value: 8.96e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568917448     8 LSVVLPGDILKSTTVHGSKPMMDLLVFLCAQYHLNPSSHTIDLLSAEENLIkfKPNTPIGMLDVEKV 74
Cdd:pfam02196    2 CRVYLPDGQRTVVQVRPGETVRDALSKLCKKRGLNPEACDVYLVGGDKYPL--DLDTDSSTLEGEEV 66
 
Name Accession Description Interval E-value
Cobl pfam09469
Cordon-bleu ubiquitin-like domain; The Cordon-bleu protein domain is highly conserved among ...
92-168 3.67e-41

Cordon-bleu ubiquitin-like domain; The Cordon-bleu protein domain is highly conserved among vertebrates. The sequence contains three repeated lysine, arginine, and proline-rich regions, the KKRAP motif. The exact function of the protein is unknown but it is thought to be involved in mid-brain neural tube closure. It is expressed specifically in the node. This domain has a ubiquitin-like fold.


Pssm-ID: 462810  Cd Length: 79  Bit Score: 145.81  E-value: 3.67e-41
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568917448    92 EKTVRVVINFKKTQKTIVRVSPHAPLQDLAPIICSKCEFDPLHTVLLKDYQAQEPLDLTKSLNDLGLRELYAMDISR 168
Cdd:pfam09469    1 EKTVRLVVNYKKTQKAVVRVSPHVPLQELLPIICSKCEFDPLHVLLLKDYISQEELDLTKSLNDLGIKELYAMDVNR 77
PHA03247 PHA03247
large tegument protein UL36; Provisional
822-1093 3.85e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.03  E-value: 3.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  822 PPKAPRVTTDTGTIPFAPNLEDInnilESKFRSRASNPQAKPSSfflqMQKRASGHYVTSAAAKSVHTAPGPAPKEPtik 901
Cdd:PHA03247 2556 PPAAPPAAPDRSVPPPRPAPRPS----EPAVTSRARRPDAPPQS----ARPRAPVDDRGDPRGPAPPSPLPPDTHAP--- 2624
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  902 evqRDPQLSPEQHPSSLSErTHSAPLPNISKADDD-------------IIQKPAETSPPPVAPKPMTLraetsPPPVfpK 968
Cdd:PHA03247 2625 ---DPPPPSPSPAANEPDP-HPPPTVPPPERPRDDpapgrvsrprrarRLGRAAQASSPPQRPRRRAA-----RPTV--G 2693
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  969 PMTLPAETSPPPVFPKPMTLPAETSLPLvfpKPMTLRAETSPPPVAAKPVALPGSQGTSLNLKTLKTFGAPRPYSSSGPS 1048
Cdd:PHA03247 2694 SLTSLADPPPPPPTPEPAPHALVSATPL---PPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPA 2770
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 568917448 1049 PFALAVVKRSQSFSKACPESASEGSSALPPAATQDEKTHTVNKPT 1093
Cdd:PHA03247 2771 PPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA 2815
WH2_Wc_Cobl cd21801
third Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wc) found in ...
1139-1164 5.74e-08

third Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wc) found in protein Cordon-Bleu (Cobl) and similar proteins; This family contains the third tandem Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2), called Wc, found in protein Cordon-Bleu (Cobl), a potent actin filament nucleator that plays an important role in the reorganization of the actin cytoskeleton. It regulates neuron morphogenesis and increases branching of axons and dendrites. It also modulates dendrite branching in Purkinje cells. Cobl binds to and sequesters actin monomers (G-actin). Cobl contains three tandem WH2 (or W) domains consisting of an N-terminal alpha helix and a C-terminal LRKV motif. The first two WH2 domains have the highest binding affinity for actin. They are functionally active in actin nucleation and polymerization. The model corresponds to the first WH2 domain.


Pssm-ID: 409199  Cd Length: 26  Bit Score: 49.61  E-value: 5.74e-08
                          10        20
                  ....*....|....*....|....*.
gi 568917448 1139 DPEHVRQSLLTAIRSGEAAAKLKRVT 1164
Cdd:cd21801     1 NPEQARQALLEAIRSGEGAARLKKVP 26
PHA03247 PHA03247
large tegument protein UL36; Provisional
783-1129 4.87e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.56  E-value: 4.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  783 PATSKSSQQPQPdlKPKPSSGTERHLHRTLSSPTgtETNPPKAPRVTTDTGTIPFAPnledinnileSKFRSRASNPQAK 862
Cdd:PHA03247 2562 AAPDRSVPPPRP--APRPSEPAVTSRARRPDAPP--QSARPRAPVDDRGDPRGPAPP----------SPLPPDTHAPDPP 2627
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  863 PSSfflqMQKRASGHYVTSAAAKSVHTAPGPAPKEPTIKEVQRDPQLSPEQHPSSLSERTHSAPLPNISKADDDIIQKPA 942
Cdd:PHA03247 2628 PPS----PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPP 2703
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  943 ETSPPPVAPKPMTlraetSPPPVFPKPMTLPAETSPPPVFPKPMTLPAETSLPLVFPKPMTLRAETSPP-------PVAA 1015
Cdd:PHA03247 2704 PPPTPEPAPHALV-----SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPapappaaPAAG 2778
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448 1016 KPVALPGSQGTSLNLKTLKTFGAPRPYSSSGPSPFALAVVKRSQSFSK--ACPESASEGSSALPPAATQDekthtvNKPT 1093
Cdd:PHA03247 2779 PPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGplPPPTSAQPTAPPPPPGPPPP------SLPL 2852
                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 568917448 1094 VGSQHGDGDKQNNPVQNEHSSQVLTPADGPSFTLKR 1129
Cdd:PHA03247 2853 GGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLAR 2888
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
852-1083 2.37e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 51.80  E-value: 2.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  852 FRSRASNPQAKPSSfflqmqkRASGHYVTSAAAKSVHTAPGPAPKEPTiKEVQRDPQLSPEQHPSSLSERTHSAPLPNIS 931
Cdd:PRK12323  363 FRPGQSGGGAGPAT-------AAAAPVAQPAPAAAAPAAAAPAPAAPP-AAPAAAPAAAAAARAVAAAPARRSPAPEALA 434
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  932 KADDDIIQKPAETSPPPVAPKPMTLrAETSPPPVFPKPMTLPAETSPPPVFPKPMTLPAETS------LPLVFPKPMTLR 1005
Cdd:PRK12323  435 AARQASARGPGGAPAPAPAPAAAPA-AAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDpppweeLPPEFASPAPAQ 513
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568917448 1006 AETSPPPVAAKPVALPGSQGTSlnlktlktfgAPRPYSSSGPSPfALAVVKRSQSFSKACPESASEGSSALPPAATQD 1083
Cdd:PRK12323  514 PDAAPAGWVAESIPDPATADPD----------DAFETLAPAPAA-APAPRAAAATEPVVAPRPPRASASGLPDMFDGD 580
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
783-1080 2.26e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 49.00  E-value: 2.26e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448   783 PATSKSSQQPQPDLKPKP--SSGTERHLHRTLSSPTGTETNPPKAPRVTTDTGTIPFApnledinnILESKFRSRASNPQ 860
Cdd:pfam03154  212 PATSQPPNQTQSTAAPHTliQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQP--------SLHGQMPPMPHSLQ 283
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448   861 AKPSsfFLQMQKRASGHYVTSAAAKSvHTAPGPAPKEPTikEVQRDPQLSPEQHPSSLSERTHSAPLPNISKADDDIiqK 940
Cdd:pfam03154  284 TGPS--HMQHPVPPQPFPLTPQSSQS-QVPPGPSPAAPG--QSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHI--K 356
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448   941 PAETSPPPVAPKPmtlRAETSPPPVF-PKPMTLPAETSPPPVFpKPMTLPAETSLPLVFPKPMTLRAETSP-PPVAAKPV 1018
Cdd:pfam03154  357 PPPTTPIPQLPNP---QSHKHPPHLSgPSPFQMNSNLPPPPAL-KPLSSLSTHHPPSAHPPPLQLMPQSQQlPPPPAQPP 432
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568917448  1019 ALPGSQGTSLNLKTLKTFGAPRPYSSSGP---SPFALAVVKRSQSFSKACPESASEGSSALPPAA 1080
Cdd:pfam03154  433 VLTQSQSLPPPAASHPPTSGLHQVPSQSPfpqHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSS 497
PHA03247 PHA03247
large tegument protein UL36; Provisional
783-1078 3.60e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 3.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  783 PATSKSSQQPQPDLKPKPSSGTERHLHRTLSSPTGTETNPPKAPRVTTDTGTIpfapnledinnilESKFRSRASNPQAK 862
Cdd:PHA03247 2609 RGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV-------------SRPRRARRLGRAAQ 2675
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  863 PSSFFLQMQKRASGHYVTSAAAKSVHTAPGPAPKEPTIKEVQRDPQlspeqhPSSLSERTHSAPLPNISKADDDIIQKPA 942
Cdd:PHA03247 2676 ASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPL------PPGPAAARQASPALPAAPAPPAVPAGPA 2749
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  943 ETSPPPVAPKPMTLRAETSPPPVFPKPMTLPAETSPPPVFP------------KPMTLPAETSLPLVFPKPMTLRAETSP 1010
Cdd:PHA03247 2750 TPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASlsesreslpspwDPADPPAAVLAPAAALPPAASPAGPLP 2829
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568917448 1011 PPVAAKPVALPGSQGTSLNLKTLKTFGAP------RPYSSSGPSPFALAVVKRSQSFSKACPESASEgSSALPP 1078
Cdd:PHA03247 2830 PPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvrrRPPSRSPAAKPAAPARPPVRRLARPAVSRSTE-SFALPP 2902
PHA03378 PHA03378
EBNA-3B; Provisional
760-1045 3.82e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 48.14  E-value: 3.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  760 KMLPVGQRHTIENMTETSMQTEVPATSKSSQQPQPDLKPKPSsgterhlhrTLSSPTGTETNPPK--APR-VTTDTGTIP 836
Cdd:PHA03378  562 QLLPAPGLGPLQIQPLTSPTTSQLASSAPSYAQTPWPVPHPS---------QTPEPPTTQSHIPEtsAPRqWPMPLRPIP 632
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  837 FAPNLEDINNILESKFRSRASNPQAKPSSFFLQMQKRASGHYVTSAAAKSVHTAPGPAPKepTIKEVQRDP-QLSPEQHP 915
Cdd:PHA03378  633 MRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQPSPTGANTMLPIQWAPG--TMQPPPRAPtPMRPPAAP 710
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  916 SSLSERTHSAPLPNISKADDDIIQKPAETSPPPvAPKPMTLRAETSPPPVFPKPMTLPAETSPPPV-FPKPMTLPAETSL 994
Cdd:PHA03378  711 PGRAQRPAAATGRARPPAAAPGRARPPAAAPGR-ARPPAAAPGRARPPAAAPGRARPPAAAPGAPTpQPPPQAPPAPQQR 789
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568917448  995 PLVFPKPMTlRAETSPPPVAAKPVALPGSQG-TSLNLKTLKTFGAPRPYSSS 1045
Cdd:PHA03378  790 PRGAPTPQP-PPQAGPTSMQLMPRAAPGQQGpTKQILRQLLTGGVKRGRPSL 840
PHA03247 PHA03247
large tegument protein UL36; Provisional
673-1049 4.68e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 4.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  673 EKEPACTYGNNVPLSPVDGSNKNPAASylKNFPLYRQDSNPKPKPSNEITREYIPKIGMTTYKIVPPKSLEMAKDWESeA 752
Cdd:PHA03247 2586 ARRPDAPPQSARPRAPVDDRGDPRGPA--PPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV-S 2662
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  753 MGRKDDQKMLPVGQRHTIENMTETSMQTEVPATSKSSQQPQPDLKPKPSSgteRHLHRTLSSPTGTETNPPKAPRVTTDT 832
Cdd:PHA03247 2663 RPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAP---HALVSATPLPPGPAAARQASPALPAAP 2739
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  833 GT--IPFAPNLEDINNILESKFRSRASNPQAKPSSFFLQMQKRASGHYVTSAAAKSVHTAPGPAPKEPTIKEVQRDPQLS 910
Cdd:PHA03247 2740 APpaVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALP 2819
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  911 PEQHPSSLSerthsAPLPNISKADDDIIQKPAETSPPP---VAPK-PMTLRAETSPPPvfpkpmTLPAETSPPPVfpKPM 986
Cdd:PHA03247 2820 PAASPAGPL-----PPPTSAQPTAPPPPPGPPPPSLPLggsVAPGgDVRRRPPSRSPA------AKPAAPARPPV--RRL 2886
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568917448  987 TLPAETSLPLVFPKPMTLRAETSPPPVAAKPVALPGSQGTSLNLKTLKTFGAPRPYSSSGPSP 1049
Cdd:PHA03247 2887 ARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDP 2949
PRK10263 PRK10263
DNA translocase FtsK; Provisional
775-1049 1.16e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 46.62  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  775 ETSMQT-EVPATSKSSQQPQPDLKPKPssgterhlhrtlssptGTETNPPK-APRVTTDTGTIPFAPNLEDINNILESKF 852
Cdd:PRK10263  338 EPVTQTpPVASVDVPPAQPTVAWQPVP----------------GPQTGEPViAPAPEGYPQQSQYAQPAVQYNEPLQQPV 401
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  853 rsrasnPQAKPSSFFLQMQKRASGHYVTSAAAKSVHTAPGPAPKEPTIKEV-QRDPQLSPEQH-PSSLSERTHSAPLPni 930
Cdd:PRK10263  402 ------QPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAwQAEEQQSTFAPqSTYQTEQTYQQPAA-- 473
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  931 skADDDIIQKPAETSPPPVAPKPMTLRAETSPPPVF-----------------------PKPMTLPAETSPPPVFPKPMT 987
Cdd:PRK10263  474 --QEPLYQQPQPVEQQPVVEPEPVVEETKPARPPLYyfeeveekrarereqlaawyqpiPEPVKEPEPIKSSLKAPSVAA 551
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568917448  988 LPAETSLPLVFPKPMTLRAETSPPPVAAKpVALPgsqgtslnLKTLKTFGAPRPYSSSGPSP 1049
Cdd:PRK10263  552 VPPVEAAAAVSPLASGVKKATLATGAAAT-VAAP--------VFSLANSGGPRPQVKEGIGP 604
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
907-1026 2.43e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 45.15  E-value: 2.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  907 PQLSPEQHPSSLSERTHSAPLPNiSKADDDIIQKPAETSPPPVAPKPMTlRAETSPPPVfPKPMTLPAETSPPPVFPKPM 986
Cdd:PRK14971  371 GGRGPKQHIKPVFTQPAAAPQPS-AAAAASPSPSQSSAAAQPSAPQSAT-QPAGTPPTV-SVDPPAAVPVNPPSTAPQAV 447
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 568917448  987 TLPAETSlplvfPKPMTLRAETSPPPVAAKPVALPGSQGT 1026
Cdd:PRK14971  448 RPAQFKE-----EKKIPVSKVSSLGPSTLRPIQEKAEQAT 482
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
940-1029 9.21e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 43.26  E-value: 9.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  940 KPAETSPPPVAPKPMTLRAETSPPPVFPKPMTLPAETSPPPVFPKPmtlPAETSLPLVFPKPMTLRAETSPPPVAAK--P 1017
Cdd:PRK14950  370 KPTAAAPSPVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPR---PVAPPVPHTPESAPKLTRAAIPVDEKPKytP 446
                          90
                  ....*....|..
gi 568917448 1018 VALPGSQGTSLN 1029
Cdd:PRK14950  447 PAPPKEEEKALI 458
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
879-1190 1.02e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.62  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  879 VTSAAAKSVHTAPGPAPKEPTIKEVQRDPQLSPEQHPSSL---SERTHSAPLPNISKADDDI--IQKPAETSPPPVAPKP 953
Cdd:PHA03307   56 VAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLapaSPAREGSPTPPGPSSPDPPppTPPPASPPPSPAPDLS 135
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  954 MTLRAETSPPPVfPKPMTLPAETSPPPVfpkpmTLPAETSLPLVFPKPMTLRAETSPPPVAAKPVALPGSqgtslnlktl 1033
Cdd:PHA03307  136 EMLRPVGSPGPP-PAASPPAAGASPAAV-----ASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPP---------- 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448 1034 ktfGAPRPYSSSGPSPFALAVVkrsqsfskaCPESASEGSSALPPAATQDEKTHtvnkpTVGSQHGDGDKQNNPVQNEHS 1113
Cdd:PHA03307  200 ---AAASPRPPRRSSPISASAS---------SPAPAPGRSAADDAGASSSDSSS-----SESSGCGWGPENECPLPRPAP 262
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568917448 1114 SQVLTPADGPSFTLKRqssltfqSSDPEHVRQSLLTAIRSGEAAAKLKRVTVPSNTISVNGKSGLSQSMSIDAQDSR 1190
Cdd:PHA03307  263 ITLPTRIWEASGWNGP-------SSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSS 332
BimA_second NF040983
trimeric autotransporter actin-nucleating factor BimA; This HMM describes BimA (Burkholderia ...
941-1021 1.06e-03

trimeric autotransporter actin-nucleating factor BimA; This HMM describes BimA (Burkholderia intracellular motility A), WP_004266405.1-like proteins in Burkholderia mallei or B. pseudomallei. The term BimA has also been used for WP_011205626.1-like homologs that have a very different N-terminal half.


Pssm-ID: 468913 [Multi-domain]  Cd Length: 382  Bit Score: 42.97  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  941 PAETSPPPVAPKPMTLRAETSPPPVFPKPMTLPAETSPPPVFPKPMTLPAETSLPLVFPKPMTLRAETSPPPVaaKPVAL 1020
Cdd:NF040983   86 PNKVPPPPPPPPPPPPPPPTPPPPPPPPPPPPPPSPPPPPPPSPPPSPPPPTTTPPTRTTPSTTTPTPSMHPI--QPTQL 163

                  .
gi 568917448 1021 P 1021
Cdd:NF040983  164 P 164
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
810-1011 1.08e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.33  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  810 RTLSSPTGTETNPPKAPRVTTDTGTIPFAPNLEDiNNILESKFRSRASNPQAKPSSFFLQMQKRASGHYVTSAAAKSVHT 889
Cdd:PRK12323  376 TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAA-PAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAP 454
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  890 APGPAPKEPTIKEVQRDPQLSPEQHPSSLSERTHSAPLPNISKADDDIIQKPAETSPPPVAPKPMTLRAETSPPPVFPKP 969
Cdd:PRK12323  455 AAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADP 534
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 568917448  970 mTLPAETSPPPVFPKPMTLPAETSLPLVFPKPMTLRAETSPP 1011
Cdd:PRK12323  535 -DDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPD 575
PHA03378 PHA03378
EBNA-3B; Provisional
892-1053 1.70e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 42.75  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  892 GPAPKEPtikevqrdPQLSPEQHPSSLSERTH--SAPLPNISKADDDIIQKPAETSPPPVAPKPMtlRAETSPPPVFPKP 969
Cdd:PHA03378  648 FPTPHQP--------PQVEITPYKPTWTQIGHipYQPSPTGANTMLPIQWAPGTMQPPPRAPTPM--RPPAAPPGRAQRP 717
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  970 MTLPAETSPPPVFPKPMTLPAETSLPLVFPKPMTLRAE-------TSPPPVAA--KPVALPGSQGTSLNLKTLKTFGAPR 1040
Cdd:PHA03378  718 AAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARppaaapgRARPPAAApgAPTPQPPPQAPPAPQQRPRGAPTPQ 797
                         170
                  ....*....|...
gi 568917448 1041 PYSSSGPSPFALA 1053
Cdd:PHA03378  798 PPPQAGPTSMQLM 810
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
893-1126 1.93e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.45  E-value: 1.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448   893 PAPKEPTIKEVQRDPQLSPEQHPSSLSERTHSAPLPNISKADDDIIQKPAETSPPPVAPKPMTLRAETSPPPVFPKPMTL 972
Cdd:pfam03154  221 TQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPL 300
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448   973 PAETSPPPVFPKPMT-LPAETSLPLVFPKPMTLRAETSPP---PVAAKPVALPgsqgtslNLKTLKTFGAPR-------- 1040
Cdd:pfam03154  301 TPQSSQSQVPPGPSPaAPGQSQQRIHTPPSQSQLQSQQPPreqPLPPAPLSMP-------HIKPPPTTPIPQlpnpqshk 373
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  1041 -PYSSSGPSPFAL-------AVVKRSQSFSKACPESA--------SEGSSALPPAATQDEKTHTVNKPTVGSQH-GDGDK 1103
Cdd:pfam03154  374 hPPHLSGPSPFQMnsnlpppPALKPLSSLSTHHPPSAhppplqlmPQSQQLPPPPAQPPVLTQSQSLPPPAASHpPTSGL 453
                          250       260
                   ....*....|....*....|...
gi 568917448  1104 QNNPVQNEHSSQVLTPADGPSFT 1126
Cdd:pfam03154  454 HQVPSQSPFPQHPFVPGGPPPIT 476
PHA03247 PHA03247
large tegument protein UL36; Provisional
783-1043 2.07e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 2.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  783 PATSKSSQQPQPDLKPKPSSGTERHLHRTlSSPTGTETNPPKAPRVTTDTGTIPFAPNLEDINNILESKFRSRASNPQAK 862
Cdd:PHA03247 2793 ESRESLPSPWDPADPPAAVLAPAAALPPA-ASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSP 2871
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  863 PSSfflqmqkrasghyVTSAAAKSVHTAPGPAPKEPTIKEVQRDPQLSPEQHPSSLSERTHSAPLPniskadddiiQKPA 942
Cdd:PHA03247 2872 AAK-------------PAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPP----------PPPQ 2928
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  943 ETSPPPVAPKPmtlraetsPPPVFPKPMTLPAeTSPPPVFPKP---MTLPAETSLPLVF---PKPMTLRAETSPPPVAAK 1016
Cdd:PHA03247 2929 PQPPPPPPPRP--------QPPLAPTTDPAGA-GEPSGAVPQPwlgALVPGRVAVPRFRvpqPAPSREAPASSTPPLTGH 2999
                         250       260
                  ....*....|....*....|....*..
gi 568917448 1017 PVALPGSQGTSLnlkTLKTFGAPRPYS 1043
Cdd:PHA03247 3000 SLSRVSSWASSL---ALHEETDPPPVS 3023
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
891-1021 2.74e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 41.68  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  891 PGPAPKEPTIKEVQRDPQlsPEQHPSSLSERTHSAPLPNISKADddiIQKPAETSPPPVAPKPMTLRAETSPPPVFPKPM 970
Cdd:NF033839  345 PQLETPKPEVKPQPEKPK--PEVKPQPEKPKPEVKPQPETPKPE---VKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPE 419
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568917448  971 TLPA------ETSPPPVFPKPMTLP-AETSLPLVFPKPMTLRAETSPPPVAAKPVALP 1021
Cdd:NF033839  420 VKPQpekpkpEVKPQPEKPKPEVKPqPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKP 477
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
939-1034 2.81e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 42.18  E-value: 2.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  939 QKPAETSPPPVAPKPMTLRAETSPPPVFPKPMTLPAETSPPPVFPKPMTLPAETSLPlvfpkpmtlrAETSPPPVAAKPV 1018
Cdd:PRK12270   36 YGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAA----------AAAPAAPPAAAAA 105
                          90
                  ....*....|....*.
gi 568917448 1019 ALPGSQGTSLNLKTLK 1034
Cdd:PRK12270  106 AAPAAAAVEDEVTPLR 121
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
940-1086 6.60e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 40.62  E-value: 6.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  940 KPAETSPPPVAPKPMTLRAETSPPPVFPKPMTLPAETSPPPVFPKPM------TLPAETSLPLVFPKPMTLRAETSPPPV 1013
Cdd:PRK07994  360 HPAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASApqqapaVPLPETTSQLLAARQQLQRAQGATKAK 439
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568917448 1014 AAKPVALPGSQGTSLNLKTLKTFgAPRPYSSSGPSPFALAVVKRSQSfskacPESASEGSSALPPAATQ---DEKT 1086
Cdd:PRK07994  440 KSEPAAASRARPVNSALERLASV-RPAPSALEKAPAKKEAYRWKATN-----PVEVKKEPVATPKALKKaleHEKT 509
BimA_second NF040983
trimeric autotransporter actin-nucleating factor BimA; This HMM describes BimA (Burkholderia ...
938-1023 7.22e-03

trimeric autotransporter actin-nucleating factor BimA; This HMM describes BimA (Burkholderia intracellular motility A), WP_004266405.1-like proteins in Burkholderia mallei or B. pseudomallei. The term BimA has also been used for WP_011205626.1-like homologs that have a very different N-terminal half.


Pssm-ID: 468913 [Multi-domain]  Cd Length: 382  Bit Score: 40.27  E-value: 7.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568917448  938 IQKPAETSPPPVAPKPMTLRAETSPPPVFPKPMTLPAETSPPPVFPKPMTLPAETSLPLVfPKPMTLRAETSPPPVAAKP 1017
Cdd:NF040983   89 VPPPPPPPPPPPPPPPTPPPPPPPPPPPPPPSPPPPPPPSPPPSPPPPTTTPPTRTTPST-TTPTPSMHPIQPTQLPSIP 167

                  ....*.
gi 568917448 1018 VALPGS 1023
Cdd:NF040983  168 NATPTS 173
RBD pfam02196
Raf-like Ras-binding domain;
8-74 8.96e-03

Raf-like Ras-binding domain;


Pssm-ID: 460485  Cd Length: 69  Bit Score: 35.96  E-value: 8.96e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568917448     8 LSVVLPGDILKSTTVHGSKPMMDLLVFLCAQYHLNPSSHTIDLLSAEENLIkfKPNTPIGMLDVEKV 74
Cdd:pfam02196    2 CRVYLPDGQRTVVQVRPGETVRDALSKLCKKRGLNPEACDVYLVGGDKYPL--DLDTDSSTLEGEEV 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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