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Conserved domains on  [gi|564388366|ref|XP_006252862|]
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mediator of RNA polymerase II transcription subunit 26 isoform X2 [Rattus norvegicus]

Protein Classification

TFIIS N-terminal domain-containing protein( domain architecture ID 12213109)

TFIIS (transcription elongation factor S-II) N-terminal domain-containing protein contains structural motifs that are responsible for interacting with RNA polymerase II (RNAPII) and mediating its catalytic activities

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Med26_C pfam15693
Mediator complex subunit 26 C-terminal; Med26_C is the C-terminal domain of subunit 26 of the ...
 397-576 1.52e-99

Mediator complex subunit 26 C-terminal; Med26_C is the C-terminal domain of subunit 26 of the Mediator complex in eukaryotes. Med19 and Med26 act synergistically to mediate the interaction between REST (a Kruppel-type zinc finger transcription factor that binds to a 21-bp RE1 silencing element present in over 900 human genes) and Mediator. The C-terminal domain is critical and sufficient for its assembly into Mediator and its interaction with Pol II. The most highly conserved C-terminal amino acids are critical for these interactions because deletion of the last eight amino acids from the Med26 C terminus disrupted binding to Mediator and Pol II.


:

Pssm-ID: 464806  Cd Length: 182  Bit Score: 299.65  E-value: 1.52e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  397 RLKERKLTFDPMTRQIRPLTQKEPVRADSPVPTEQ--LPRTELEQQEAKASLQSPFEQTNWKELSRNEIIQSYLSRQSSL 474
Cdd:pfam15693   1 RLKERRLTFDPVTGQIKPLTQKESSQEDEPVHPEQpeTQRSESELKQNPLPLPSPFQQTNWKELSRNEIIQSYLSRQSSL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  475 LSSSGAQTPGAHHFMAEYLKQEESSRQGARQPHVLLPLPTPTDLPGLTREVTQDDLDRIQAQQWPGVNGCEDTQGNWYDW 554
Cdd:pfam15693  81 LTSSGAQTPGAHFFMSEYLKQEESTRKEARKTHVLVPDSPPTDLPGVSREVTQEDLNRIHAQHWPGVNGCYDTKGNWYDW 160

                         170       180
                  ....*....|....*....|..
gi 564388366  555 TQCISLDPHGDDGRLNILPYVC 576
Cdd:pfam15693 161 TQCISLDPHGDESRLNILPYVC 182
Med26_M pfam15694
Mediator complex subunit 26 middle domain; Med26_M is the middle domain of subunit 26 of ...
 168-395 6.36e-86

Mediator complex subunit 26 middle domain; Med26_M is the middle domain of subunit 26 of Mediator. Med19 and Med26 act synergistically to mediate the interaction between REST (a Kruppel-type zinc finger transcription factor that binds to a 21-bp RE1 silencing element present in over 900 human genes) and Mediator.


:

Pssm-ID: 464807 [Multi-domain]  Cd Length: 255  Bit Score: 267.51  E-value: 6.36e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  168 SPLPTNGISGSPESLPSPLDGSGHLGPDGSRLELSENEKHStKIPVNAVRPRPSSPGLGKPPVPCLQTKAAQLQPLDRAD 247
Cdd:pfam15694   2 SPPPTNGIGGSPESFPSPLDQGLHTGPDRSRLEHLENDKHN-KIPVNAVRPHTSSPGLGKPPSTSSLLKAAVLQQQARLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  248 EPPGPPYPRGSPRCSISPRNSRHEgSFARHRSSYIPKGPVSSPSPRPQPLDtTQVPSPLPLAQPPTPPV--RRLD--LLP 323
Cdd:pfam15694  81 ETGGPPQPKSPRCSSFSPRNSRHE-TFARRSSTYAPKGSVPSPSPRSQVLD-AQVPSPLPLSQPSTPPVqaKRLEkpPQS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  324 NAESPVHWPEQP--EGHPRL-----------TGPAC------------RAGLSPDSSKADSDAASSGGSDSKKKKRYRPR 378
Cdd:pfam15694 159 SPESSQHWLEQSdsESHQRHqdgsatllsqsVSPGCktplhpgenslpHLGFSPDSSKADSDGAASSGSDSKKRKRYRPR 238

                         250
                  ....*....|....*..
gi 564388366  379 DYTVNLDGQVAEAGVKP 395
Cdd:pfam15694 239 DYTVNLDGQVAEGGVKP 255
TFS2N smart00509
Domain in the N-terminus of transcription elongation factor S-II (and elsewhere);
16-76 1.75e-16

Domain in the N-terminus of transcription elongation factor S-II (and elsewhere);


:

Pssm-ID: 197766 [Multi-domain]  Cd Length: 75  Bit Score: 74.27  E-value: 1.75e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564388366    16 RNMVAVLEVISSLERYPITKEALEETRLGKLINDVRKKtKNEELAKRAKRLLRSWQKLIEP 76
Cdd:smart00509  16 KEVSRCLDILKKLKKLPITVDLLEETRIGKKVNGLRKH-KNEEIRKLAKKLIKSWKKLVYS 75
 
Name Accession Description Interval E-value
Med26_C pfam15693
Mediator complex subunit 26 C-terminal; Med26_C is the C-terminal domain of subunit 26 of the ...
 397-576 1.52e-99

Mediator complex subunit 26 C-terminal; Med26_C is the C-terminal domain of subunit 26 of the Mediator complex in eukaryotes. Med19 and Med26 act synergistically to mediate the interaction between REST (a Kruppel-type zinc finger transcription factor that binds to a 21-bp RE1 silencing element present in over 900 human genes) and Mediator. The C-terminal domain is critical and sufficient for its assembly into Mediator and its interaction with Pol II. The most highly conserved C-terminal amino acids are critical for these interactions because deletion of the last eight amino acids from the Med26 C terminus disrupted binding to Mediator and Pol II.


Pssm-ID: 464806  Cd Length: 182  Bit Score: 299.65  E-value: 1.52e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  397 RLKERKLTFDPMTRQIRPLTQKEPVRADSPVPTEQ--LPRTELEQQEAKASLQSPFEQTNWKELSRNEIIQSYLSRQSSL 474
Cdd:pfam15693   1 RLKERRLTFDPVTGQIKPLTQKESSQEDEPVHPEQpeTQRSESELKQNPLPLPSPFQQTNWKELSRNEIIQSYLSRQSSL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  475 LSSSGAQTPGAHHFMAEYLKQEESSRQGARQPHVLLPLPTPTDLPGLTREVTQDDLDRIQAQQWPGVNGCEDTQGNWYDW 554
Cdd:pfam15693  81 LTSSGAQTPGAHFFMSEYLKQEESTRKEARKTHVLVPDSPPTDLPGVSREVTQEDLNRIHAQHWPGVNGCYDTKGNWYDW 160

                         170       180
                  ....*....|....*....|..
gi 564388366  555 TQCISLDPHGDDGRLNILPYVC 576
Cdd:pfam15693 161 TQCISLDPHGDESRLNILPYVC 182
Med26_M pfam15694
Mediator complex subunit 26 middle domain; Med26_M is the middle domain of subunit 26 of ...
 168-395 6.36e-86

Mediator complex subunit 26 middle domain; Med26_M is the middle domain of subunit 26 of Mediator. Med19 and Med26 act synergistically to mediate the interaction between REST (a Kruppel-type zinc finger transcription factor that binds to a 21-bp RE1 silencing element present in over 900 human genes) and Mediator.


Pssm-ID: 464807 [Multi-domain]  Cd Length: 255  Bit Score: 267.51  E-value: 6.36e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  168 SPLPTNGISGSPESLPSPLDGSGHLGPDGSRLELSENEKHStKIPVNAVRPRPSSPGLGKPPVPCLQTKAAQLQPLDRAD 247
Cdd:pfam15694   2 SPPPTNGIGGSPESFPSPLDQGLHTGPDRSRLEHLENDKHN-KIPVNAVRPHTSSPGLGKPPSTSSLLKAAVLQQQARLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  248 EPPGPPYPRGSPRCSISPRNSRHEgSFARHRSSYIPKGPVSSPSPRPQPLDtTQVPSPLPLAQPPTPPV--RRLD--LLP 323
Cdd:pfam15694  81 ETGGPPQPKSPRCSSFSPRNSRHE-TFARRSSTYAPKGSVPSPSPRSQVLD-AQVPSPLPLSQPSTPPVqaKRLEkpPQS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  324 NAESPVHWPEQP--EGHPRL-----------TGPAC------------RAGLSPDSSKADSDAASSGGSDSKKKKRYRPR 378
Cdd:pfam15694 159 SPESSQHWLEQSdsESHQRHqdgsatllsqsVSPGCktplhpgenslpHLGFSPDSSKADSDGAASSGSDSKKRKRYRPR 238

                         250
                  ....*....|....*..
gi 564388366  379 DYTVNLDGQVAEAGVKP 395
Cdd:pfam15694 239 DYTVNLDGQVAEGGVKP 255
TFS2N smart00509
Domain in the N-terminus of transcription elongation factor S-II (and elsewhere);
16-76 1.75e-16

Domain in the N-terminus of transcription elongation factor S-II (and elsewhere);


Pssm-ID: 197766 [Multi-domain]  Cd Length: 75  Bit Score: 74.27  E-value: 1.75e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564388366    16 RNMVAVLEVISSLERYPITKEALEETRLGKLINDVRKKtKNEELAKRAKRLLRSWQKLIEP 76
Cdd:smart00509  16 KEVSRCLDILKKLKKLPITVDLLEETRIGKKVNGLRKH-KNEEIRKLAKKLIKSWKKLVYS 75
TFIIS_I cd00183
N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a ...
 11-75 8.39e-16

N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme


Pssm-ID: 238107  Cd Length: 76  Bit Score: 72.34  E-value: 8.39e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564388366  11 PMSEIRNMVAVLEVISSLERYPITKEALEETRLGKLINDVRKKtKNEELAKRAKRLLRSWQKLIE 75
Cdd:cd00183   13 KKDSNEEVSRLLDLLRLLKKLPLTVEILKETRIGKKVNSLRKH-SNEKIRKLAKALIKSWKKLVD 76
Med26 pfam08711
TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is ...
 23-74 7.13e-14

TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. Notably, the 'small' and 'large' Mediator complexes differ in their subunit composition: the Med26 subunit preferentially associates with the small, active complex, whereas cdk8, cyclin C, Med12 and Med13 associate with the large Mediator complex. This family includesthe C terminal region of a number of eukaryotic hypothetical proteins which are homologous to the Saccharomyces cerevisiae protein IWS1. IWS1 is known to be an Pol II transcription elongation factor and interacts with Spt6 and Spt5.


Pssm-ID: 462573 [Multi-domain]  Cd Length: 52  Bit Score: 66.00  E-value: 7.13e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 564388366   23 EVISSLERYPITKEALEETRLGKLINDVRKKTKNEELAKRAKRLLRSWQKLI 74
Cdd:pfam08711   1 KLLKKLEKLPVTLELLKSTGIGKVVNKLRKHKENPEIKKLAKELVKKWKRLV 52
PHA03247 PHA03247
large tegument protein UL36; Provisional
 137-452 4.47e-12

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 69.58  E-value: 4.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  137 RKRRGDQRDLGHPGPPHKVSKGSPDPLVPNASPLPTNGISGSPESLPSPLDGSGHLGPDGSRLELSENEKHSTKIPVNAV 216
Cdd:PHA03247 2599 RAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASS 2678

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  217 RPRPSSPGLGKPPVPCLQtkaaqlqplDRADEPPGPPYPRGSPRCSISPRNSRHEGSFARHRSSYIPKGPVSSPSP---- 292
Cdd:PHA03247 2679 PPQRPRRRAARPTVGSLT---------SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPagpa 2749

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  293 -------RPQPLDTTQVPSPLPLAQPPTPPVRRLDLLPNAESPVHWPEQPE----GHPRLTGPACRAGLSPDSSKADSDA 361
Cdd:PHA03247 2750 tpggparPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSpwdpADPPAAVLAPAAALPPAASPAGPLP 2829

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  362 ASSGGSDSKKKKRYRPRDYTVNLDGQVAEAG---------------VKPVRLKERKLTFDPMTRQIRPLTQKEPVRADSP 426
Cdd:PHA03247 2830 PPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGdvrrrppsrspaakpAAPARPPVRRLARPAVSRSTESFALPPDQPERPP 2909

                         330       340
                  ....*....|....*....|....*.
gi 564388366  427 VPTEQLPRTELEQQEAKASLQSPFEQ 452
Cdd:PHA03247 2910 QPQAPPPPQPQPQPPPPPQPQPPPPP 2935
TFSII TIGR01385
transcription elongation factor S-II; This model represents eukaryotic transcription ...
 16-79 1.42e-08

transcription elongation factor S-II; This model represents eukaryotic transcription elongation factor S-II. This protein allows stalled RNA transcription complexes to perform a cleavage of the nascent RNA and restart at the newly generated 3-prime end.


Pssm-ID: 273592 [Multi-domain]  Cd Length: 299  Bit Score: 56.39  E-value: 1.42e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564388366   16 RNMVAVLEVISSLERYPITKEALEETRLGKLINDVRKKTkNEELAKRAKRLLRSWQKLIEPVHQ 79
Cdd:TIGR01385  18 KNVEQCLDILHQLKEFPPTEELLQETKVGVKVNKLRKHP-NEDISKLAKKIIKSWKKVVDKNKS 80
 
Name Accession Description Interval E-value
Med26_C pfam15693
Mediator complex subunit 26 C-terminal; Med26_C is the C-terminal domain of subunit 26 of the ...
 397-576 1.52e-99

Mediator complex subunit 26 C-terminal; Med26_C is the C-terminal domain of subunit 26 of the Mediator complex in eukaryotes. Med19 and Med26 act synergistically to mediate the interaction between REST (a Kruppel-type zinc finger transcription factor that binds to a 21-bp RE1 silencing element present in over 900 human genes) and Mediator. The C-terminal domain is critical and sufficient for its assembly into Mediator and its interaction with Pol II. The most highly conserved C-terminal amino acids are critical for these interactions because deletion of the last eight amino acids from the Med26 C terminus disrupted binding to Mediator and Pol II.


Pssm-ID: 464806  Cd Length: 182  Bit Score: 299.65  E-value: 1.52e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  397 RLKERKLTFDPMTRQIRPLTQKEPVRADSPVPTEQ--LPRTELEQQEAKASLQSPFEQTNWKELSRNEIIQSYLSRQSSL 474
Cdd:pfam15693   1 RLKERRLTFDPVTGQIKPLTQKESSQEDEPVHPEQpeTQRSESELKQNPLPLPSPFQQTNWKELSRNEIIQSYLSRQSSL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  475 LSSSGAQTPGAHHFMAEYLKQEESSRQGARQPHVLLPLPTPTDLPGLTREVTQDDLDRIQAQQWPGVNGCEDTQGNWYDW 554
Cdd:pfam15693  81 LTSSGAQTPGAHFFMSEYLKQEESTRKEARKTHVLVPDSPPTDLPGVSREVTQEDLNRIHAQHWPGVNGCYDTKGNWYDW 160

                         170       180
                  ....*....|....*....|..
gi 564388366  555 TQCISLDPHGDDGRLNILPYVC 576
Cdd:pfam15693 161 TQCISLDPHGDESRLNILPYVC 182
Med26_M pfam15694
Mediator complex subunit 26 middle domain; Med26_M is the middle domain of subunit 26 of ...
 168-395 6.36e-86

Mediator complex subunit 26 middle domain; Med26_M is the middle domain of subunit 26 of Mediator. Med19 and Med26 act synergistically to mediate the interaction between REST (a Kruppel-type zinc finger transcription factor that binds to a 21-bp RE1 silencing element present in over 900 human genes) and Mediator.


Pssm-ID: 464807 [Multi-domain]  Cd Length: 255  Bit Score: 267.51  E-value: 6.36e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  168 SPLPTNGISGSPESLPSPLDGSGHLGPDGSRLELSENEKHStKIPVNAVRPRPSSPGLGKPPVPCLQTKAAQLQPLDRAD 247
Cdd:pfam15694   2 SPPPTNGIGGSPESFPSPLDQGLHTGPDRSRLEHLENDKHN-KIPVNAVRPHTSSPGLGKPPSTSSLLKAAVLQQQARLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  248 EPPGPPYPRGSPRCSISPRNSRHEgSFARHRSSYIPKGPVSSPSPRPQPLDtTQVPSPLPLAQPPTPPV--RRLD--LLP 323
Cdd:pfam15694  81 ETGGPPQPKSPRCSSFSPRNSRHE-TFARRSSTYAPKGSVPSPSPRSQVLD-AQVPSPLPLSQPSTPPVqaKRLEkpPQS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  324 NAESPVHWPEQP--EGHPRL-----------TGPAC------------RAGLSPDSSKADSDAASSGGSDSKKKKRYRPR 378
Cdd:pfam15694 159 SPESSQHWLEQSdsESHQRHqdgsatllsqsVSPGCktplhpgenslpHLGFSPDSSKADSDGAASSGSDSKKRKRYRPR 238

                         250
                  ....*....|....*..
gi 564388366  379 DYTVNLDGQVAEAGVKP 395
Cdd:pfam15694 239 DYTVNLDGQVAEGGVKP 255
TFS2N smart00509
Domain in the N-terminus of transcription elongation factor S-II (and elsewhere);
16-76 1.75e-16

Domain in the N-terminus of transcription elongation factor S-II (and elsewhere);


Pssm-ID: 197766 [Multi-domain]  Cd Length: 75  Bit Score: 74.27  E-value: 1.75e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564388366    16 RNMVAVLEVISSLERYPITKEALEETRLGKLINDVRKKtKNEELAKRAKRLLRSWQKLIEP 76
Cdd:smart00509  16 KEVSRCLDILKKLKKLPITVDLLEETRIGKKVNGLRKH-KNEEIRKLAKKLIKSWKKLVYS 75
TFIIS_I cd00183
N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a ...
 11-75 8.39e-16

N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme


Pssm-ID: 238107  Cd Length: 76  Bit Score: 72.34  E-value: 8.39e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564388366  11 PMSEIRNMVAVLEVISSLERYPITKEALEETRLGKLINDVRKKtKNEELAKRAKRLLRSWQKLIE 75
Cdd:cd00183   13 KKDSNEEVSRLLDLLRLLKKLPLTVEILKETRIGKKVNSLRKH-SNEKIRKLAKALIKSWKKLVD 76
Med26 pfam08711
TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is ...
 23-74 7.13e-14

TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. Notably, the 'small' and 'large' Mediator complexes differ in their subunit composition: the Med26 subunit preferentially associates with the small, active complex, whereas cdk8, cyclin C, Med12 and Med13 associate with the large Mediator complex. This family includesthe C terminal region of a number of eukaryotic hypothetical proteins which are homologous to the Saccharomyces cerevisiae protein IWS1. IWS1 is known to be an Pol II transcription elongation factor and interacts with Spt6 and Spt5.


Pssm-ID: 462573 [Multi-domain]  Cd Length: 52  Bit Score: 66.00  E-value: 7.13e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 564388366   23 EVISSLERYPITKEALEETRLGKLINDVRKKTKNEELAKRAKRLLRSWQKLI 74
Cdd:pfam08711   1 KLLKKLEKLPVTLELLKSTGIGKVVNKLRKHKENPEIKKLAKELVKKWKRLV 52
PHA03247 PHA03247
large tegument protein UL36; Provisional
 137-452 4.47e-12

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 69.58  E-value: 4.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  137 RKRRGDQRDLGHPGPPHKVSKGSPDPLVPNASPLPTNGISGSPESLPSPLDGSGHLGPDGSRLELSENEKHSTKIPVNAV 216
Cdd:PHA03247 2599 RAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASS 2678

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  217 RPRPSSPGLGKPPVPCLQtkaaqlqplDRADEPPGPPYPRGSPRCSISPRNSRHEGSFARHRSSYIPKGPVSSPSP---- 292
Cdd:PHA03247 2679 PPQRPRRRAARPTVGSLT---------SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPagpa 2749

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  293 -------RPQPLDTTQVPSPLPLAQPPTPPVRRLDLLPNAESPVHWPEQPE----GHPRLTGPACRAGLSPDSSKADSDA 361
Cdd:PHA03247 2750 tpggparPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSpwdpADPPAAVLAPAAALPPAASPAGPLP 2829

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  362 ASSGGSDSKKKKRYRPRDYTVNLDGQVAEAG---------------VKPVRLKERKLTFDPMTRQIRPLTQKEPVRADSP 426
Cdd:PHA03247 2830 PPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGdvrrrppsrspaakpAAPARPPVRRLARPAVSRSTESFALPPDQPERPP 2909

                         330       340
                  ....*....|....*....|....*.
gi 564388366  427 VPTEQLPRTELEQQEAKASLQSPFEQ 452
Cdd:PHA03247 2910 QPQAPPPPQPQPQPPPPPQPQPPPPP 2935
PHA03247 PHA03247
large tegument protein UL36; Provisional
 127-345 1.74e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 61.11  E-value: 1.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  127 PGQRLDRLGSRKRRGDQRDLGHPGPPHKVSKGSPDPLVPnASPLPTNGISGSPESLPSPLDGSGHLGPDGSRLELSENEK 206
Cdd:PHA03247 2679 PPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVS-ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARP 2757

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  207 HSTKIPVNAVRPRPSSPGLGKPP----VPCLQTKAAQLQPLDRADEPPGPPYPRGSPRCSISPRNSRHEGSFARHRSSYI 282
Cdd:PHA03247 2758 ARPPTTAGPPAPAPPAAPAAGPPrrltRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPT 2837

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564388366  283 PKGPVSSPSPRPQPLD-------------TTQVPSPLPlAQPPTPPVRRLDLLPNAESPVHWPEQPEGHPRLTGPA 345
Cdd:PHA03247 2838 APPPPPGPPPPSLPLGgsvapggdvrrrpPSRSPAAKP-AAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQ 2912
TFSII TIGR01385
transcription elongation factor S-II; This model represents eukaryotic transcription ...
 16-79 1.42e-08

transcription elongation factor S-II; This model represents eukaryotic transcription elongation factor S-II. This protein allows stalled RNA transcription complexes to perform a cleavage of the nascent RNA and restart at the newly generated 3-prime end.


Pssm-ID: 273592 [Multi-domain]  Cd Length: 299  Bit Score: 56.39  E-value: 1.42e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564388366   16 RNMVAVLEVISSLERYPITKEALEETRLGKLINDVRKKTkNEELAKRAKRLLRSWQKLIEPVHQ 79
Cdd:TIGR01385  18 KNVEQCLDILHQLKEFPPTEELLQETKVGVKVNKLRKHP-NEDISKLAKKIIKSWKKVVDKNKS 80
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 148-436 2.52e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 50.46  E-value: 2.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366 148 HPGPPhkvsKGspdplvPNASPLPTNGisgspeslpsPLDGSGHLGPDGSRLELSENEKHStkipvnavRPRPSSPG-LG 226
Cdd:PTZ00449 507 HDEPP----EG------PEASGLPPKA----------PGDKEGEEGEHEDSKESDEPKEGG--------KPGETKEGeVG 558

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366 227 KPPVPCLQTKAAQLQPLDRadEPPGPPYPRgSPRCSISPRNSrhegsfarhRSSYIPKGPVSSPSP-RPQPLDTTQVPSP 305
Cdd:PTZ00449 559 KKPGPAKEHKPSKIPTLSK--KPEFPKDPK-HPKDPEEPKKP---------KRPRSAQRPTRPKSPkLPELLDIPKSPKR 626

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366 306 LPLAQPPTPPvrrldllPNAESPVHwPEQPEGHPRLTGPAcraglSPDSSKADSDAassggsdSKKKKRYrpRDYTvnld 385
Cdd:PTZ00449 627 PESPKSPKRP-------PPPQRPSS-PERPEGPKIIKSPK-----PPKSPKPPFDP-------KFKEKFY--DDYL---- 680

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564388366 386 gQVAEAGVKPVRLKERKLTFDPMTRQIRPLTQKEPVRADSPVPTeQLPRTE 436
Cdd:PTZ00449 681 -DAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPP-KLPRDE 729
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 149-366 1.13e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 48.63  E-value: 1.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  149 PGPPHKVSKGSPDPLVPNASPLPTNGISGSPESLPSPLDG-SGHLGPDGSRLELSENEKHSTKIPVNAVRPRPSSPGLGK 227
Cdd:PHA03307  186 PSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGrSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITL 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  228 PPVPCLQTKA------AQLQPLDRADEPPGPPYPRGSPRCSISPRNSRHEGSFARHRSSYIPKGPVSSPSPRPQPLDTTQ 301
Cdd:PHA03307  266 PTRIWEASGWngpssrPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGP 345

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564388366  302 VPSPLPLAQPPtPPVRRLDLLPNAESPVHWPEQPEGHP-RLTGPACRAGLSPDSSKADSDAASSGG 366
Cdd:PHA03307  346 SPSRSPSPSRP-PPPADPSSPRKRPRPSRAPSSPAASAgRPTRRRARAAVAGRARRRDATGRFPAG 410
PHA03379 PHA03379
EBNA-3A; Provisional
 123-322 1.25e-04

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 45.05  E-value: 1.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366 123 IQRLPGQRLDRLGSRKRRGDQRDLGHPGPphkvSKGSPDPLVPNASPLPTNGISGSPESLPSPLDGSGhlgpdgsrlels 202
Cdd:PHA03379 383 LRRLHRLLLMRAGKLTERAREALEKASEP----TYGTPRPPVEKPRPEVPQSLETATSHGSAQVPEPP------------ 446

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366 203 enekhstkiPVNAVRPRPSSPGLGKPPVPCLQTKAAQLQPLDRADEPPGPPyPRGSPRCSISPRNSrheGSFARHRSSYI 282
Cdd:PHA03379 447 ---------PVHDLEPGPLHDQHSMAPCPVAQLPPGPLQDLEPGDQLPGVV-QDGRPACAPVPAPA---GPIVRPWEASL 513

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 564388366 283 PKGPVSSPSP-RPQPLDTTQVPSPLPLAQPPTPPVRRLDLL 322
Cdd:PHA03379 514 SQVPGVAFAPvMPQPMPVEPVPVPTVALERPVCPAPPLIAM 554
PHA03321 PHA03321
tegument protein VP11/12; Provisional
 240-395 1.50e-04

tegument protein VP11/12; Provisional


Pssm-ID: 223041 [Multi-domain]  Cd Length: 694  Bit Score: 44.56  E-value: 1.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366 240 LQPLDRAD-EPPGPPYPR--GSPRCSISPRNSR-------HEGSFARHRSSYIPKGPVSSPSPRPQPLDTTQV---PSPL 306
Cdd:PHA03321 432 GAPAPRRDnDPPPPPRARpgSTPACARRARAQRardagpeYVDPLGALRRLPAGAAPPPEPAAAPSPATYYTRmggGPPR 511

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366 307 PLAQPPTPPVRRLDLLPNAESPVHWPEQP------EGHPRLTGPACRAGLSPDSSKADSDAASSGGSDSKKKKRYR---- 376
Cdd:PHA03321 512 LPPRNRATETLRPDWGPPAAAPPEQMEDPylepddDRFDRRDGAAAAATSHPREAPAPDDDPIYEGVSDSEEPVYEeipt 591

                        170
                 ....*....|....*....
gi 564388366 377 PRDYtVNLDGQVAEAGVKP 395
Cdd:PHA03321 592 PRVY-QNPLPRPMEGAGEP 609
PHA03247 PHA03247
large tegument protein UL36; Provisional
 149-349 1.71e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  149 PGPPHKVSKGSPdplvPNASPLPTNGISGSPESLPSPLDGSGHLGPDGSRLELSENEKHSTKIPVNAVRPRPSSPGLGKP 228
Cdd:PHA03247 2769 PAPPAAPAAGPP----RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG 2844

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  229 PVPCLQTKAAQLQPLDRADEPPGPPYPRGSPRCSISPRNSRHEGSFARHRSSYIPKGPVSSPSPRPQPLDTTQVPSPLPL 308
Cdd:PHA03247 2845 PPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPP 2924

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 564388366  309 AQPPTPPVRRLDLLPNAESPVHWPEQPEGHPRLTGPACRAG 349
Cdd:PHA03247 2925 PPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLG 2965
PHA03378 PHA03378
EBNA-3B; Provisional
 148-335 2.02e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 44.29  E-value: 2.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366 148 HPGPPHKVSKgSPDPLVPNASPLPTNGISGSPESL-PSPLDGSGHLGPDGS-RLELSENEKHSTKIPVNAVRPRPSSPGL 225
Cdd:PHA03378 605 TPEPPTTQSH-IPETSAPRQWPMPLRPIPMRPLRMqPITFNVLVFPTPHQPpQVEITPYKPTWTQIGHIPYQPSPTGANT 683

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366 226 GKPPvpclQTKAAQLQPLDRA----DEPPGPPYPRGSPRCSISPRNSRHEGSFARHRSSYIP-------------KGPVS 288
Cdd:PHA03378 684 MLPI----QWAPGTMQPPPRAptpmRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPgrarppaaapgraRPPAA 759

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 564388366 289 SPSPRPQPLDTTQVPSPLPLAQPPTPPVRRLDLLPNAESPVHWPEQP 335
Cdd:PHA03378 760 APGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPTS 806
PHA03247 PHA03247
large tegument protein UL36; Provisional
 143-374 3.46e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 3.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  143 QRDLGHPGPPHKVS--KGSPDPLVPNASPLPTNGI-----SGSPESLPSPLDGSGHLGPDGSRLELSENEKHSTKIPVNa 215
Cdd:PHA03247  263 EGADRAPETARGATgpPPPPEAAAPNGAAAPPDGVwgaalAGAPLALPAPPDPPPPAPAGDAEEEDDEDGAMEVVSPLP- 341

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  216 vRPRPSSP-GLGKPPVPCLqTKAAQLQPLDRADEPPgppyprgsPRCSISPRNSRHegsfARHRSSYIPKGPVSSPSPRP 294
Cdd:PHA03247  342 -RPRQHYPlGFPKRRRPTW-TPPSSLEDLSAGRHHP--------KRASLPTRKRRS----ARHAATPFARGPGGDDQTRP 407

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  295 QPLDTTQVPSPLPLAQPPTPPvrrldllPNAESPVHWPEQPEGHPRLTGPACR-AGLSPDSSKADSDAASSGGSDSKKKK 373
Cdd:PHA03247  408 AAPVPASVPTPAPTPVPASAP-------PPPATPLPSAEPGSDDGPAPPPERQpPAPATEPAPDDPDDATRKALDALRER 480


                  .
gi 564388366  374 R 374
Cdd:PHA03247  481 R 481
PHA03247 PHA03247
large tegument protein UL36; Provisional
 149-371 4.58e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 4.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  149 PGPPHKVSKGSPDPLVPNASPLPTNGiSGSPESLPSPLDGSGHLGPDGsrlELSENEKHSTKIPVNAVRPRPSSPGLGKP 228
Cdd:PHA03247 2814 PAAALPPAASPAGPLPPPTSAQPTAP-PPPPGPPPPSLPLGGSVAPGG---DVRRRPPSRSPAAKPAAPARPPVRRLARP 2889

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  229 PVPCLQTKAAQLQP-LDRADEPPGPPYPRGSPRCSISPRNSRHEGSFARHRSsyiPKGPVSSPSPRPQPLDT-------- 299
Cdd:PHA03247 2890 AVSRSTESFALPPDqPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQP---PLAPTTDPAGAGEPSGAvpqpwlga 2966

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  300 ----------TQVPSPLP---LAQPPTPPVRRLDL--LPNAESPVHWPEQPEGHPrltgPACRAGLSPDSSKADSDAASS 364
Cdd:PHA03247 2967 lvpgrvavprFRVPQPAPsreAPASSTPPLTGHSLsrVSSWASSLALHEETDPPP----VSLKQTLWPPDDTEDSDADSL 3042


                  ....*..
gi 564388366  365 GGSDSKK 371
Cdd:PHA03247 3043 FDSDSER 3049
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
212-445 5.44e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.94  E-value: 5.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366 212 PVNAVRPRPSSPGLGKPPVPCLQTKAAQLQPLDRADEPPGPPYPRGSPRCSISPRnSRHEGSFARHRSSYIPKGPVSSPS 291
Cdd:PRK12323 381 PVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAA-ARQASARGPGGAPAPAPAPAAAPA 459

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366 292 PRPQPLDTTQVPSPLPLAQPPTPPVRRLDLLPNAESPVHWPEQPEGHPRLTGPACRAGLSPDSSKADSDAASSGGSDSKK 371
Cdd:PRK12323 460 AAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFE 539

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564388366 372 KKRYRPrdytvnldgqvAEAGVKPVRLKERKLTFDPMTRQIRPLTQkEPVRADSPVPTEQLPRTELEQQEAKAS 445
Cdd:PRK12323 540 TLAPAP-----------AAAPAPRAAAATEPVVAPRPPRASASGLP-DMFDGDWPALAARLPVRGLAQQLARQS 601
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 147-379 6.27e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.85  E-value: 6.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  147 GHPGPPHKVSKGSPDPLVPNASPLPTngisgSPESLPSPLDGSGHLGPdGSRLELSENEKHSTKIPVNAVRPRPSSPGLG 226
Cdd:PHA03307  104 GSPTPPGPSSPDPPPPTPPPASPPPS-----PAPDLSEMLRPVGSPGP-PPAASPPAAGASPAAVASDAASSRQAALPLS 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  227 KPP--VPCLQTKAAQLQPLDRADEPPGPPYPRGSPRCSISPRNSRhegsfARHRSSYIPKGPVSSPSPRPQPLDTTQVP- 303
Cdd:PHA03307  178 SPEetARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAP-----APGRSAADDAGASSSDSSSSESSGCGWGPe 252

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564388366  304 --SPLPLAQPPTPPVRRldllpnaESPVHWPEQPEGHPRLTGPACRAGLSPDSSKADSDAASSGGSDSKKKKRYRPRD 379
Cdd:PHA03307  253 neCPLPRPAPITLPTRI-------WEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRE 323
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
160-333 8.29e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 8.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366 160 PDPLVPNASPLPTNGISGSPESLPSPLDGSGHLGPDGSRLELSENEKHSTKIPVNAVRPRPSSPGLGKPPVPCLQTKAAQ 239
Cdd:PRK12323 404 AAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARA 483

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366 240 LQPLDRADEPPGPPYPRGSPRCSISPRNSRHEGSFARHRSSYIPKGPVSSPSPRPQPLDTTQVPSPLPLAQ-------PP 312
Cdd:PRK12323 484 APAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAaatepvvAP 563

                        170       180
                 ....*....|....*....|.
gi 564388366 313 TPPVRRLDLLPNAeSPVHWPE 333
Cdd:PRK12323 564 RPPRASASGLPDM-FDGDWPA 583
PHA03247 PHA03247
large tegument protein UL36; Provisional
 146-362 8.74e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 8.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  146 LGHPGPPHKVSKGSPD---PLVPNASPLPTNGISGSPESLPSPLDGSGHLGPDGS-------RL--------ELSENEK- 206
Cdd:PHA03247 2470 LGELFPGAPVYRRPAEarfPFAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPvgepvhpRMltwirgleELASDDAg 2549

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  207 --------------HSTKIPVNAVRPRPSSPGLG----KPPVPCLQTK-------------AAQLQPLDRADEPPGPPYP 255
Cdd:PHA03247 2550 dpppplppaappaaPDRSVPPPRPAPRPSEPAVTsrarRPDAPPQSARprapvddrgdprgPAPPSPLPPDTHAPDPPPP 2629

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  256 RGSPRCSiSPRNSRHEGSFARHRSSYIPKGPVSSPSPRPQPLDTTQVPSPLPlaQPPTPPVRRLDLLPNAES--PVHWPE 333
Cdd:PHA03247 2630 SPSPAAN-EPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPP--QRPRRRAARPTVGSLTSLadPPPPPP 2706

                         250       260
                  ....*....|....*....|....*....
gi 564388366  334 QPEGHPRLTGPACRAGLSPDSSKADSDAA 362
Cdd:PHA03247 2707 TPEPAPHALVSATPLPPGPAAARQASPAL 2735
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 283-404 6.53e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 39.41  E-value: 6.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366 283 PKGPVSSPSPRPQPLDTTQVPSPLPLAQPPTPPVRRLDllPNAESPVHWPEQPEGHPRLTGPACRAGLS-PDSSKADSDA 361
Cdd:PRK14950 378 PVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPR--PVAPPVPHTPESAPKLTRAAIPVDEKPKYtPPAPPKEEEK 455

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564388366 362 ASSGGSD---------SKKKKRYRPRDYTVNLdgqVAEAGVKPVRLKERKLT 404
Cdd:PRK14950 456 ALIADGDvleqleaiwKQILRDVPPRSPAVQA---LLSSGVRPVSVEKNTLT 504
KAR9 pfam08580
Yeast cortical protein KAR9; The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal ...
 202-319 7.79e-03

Yeast cortical protein KAR9; The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal protein required for karyogamy, correct positioning of the mitotic spindle and for orientation of cytoplasmic microtubules. KAR9 localizes at the shmoo tip in mating cells and at the tip of the growing bud in anaphase.


Pssm-ID: 430088 [Multi-domain]  Cd Length: 684  Bit Score: 39.04  E-value: 7.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388366  202 SENEKHSTKIPvnavRPRPSSPGLGKPPVpcLQTKAAQLQPLDRADEPPGPPYPRGSPRCSISPRNSRHEGSFARHRSSY 281
Cdd:pfam08580 485 LKQTKRPSKIP----RASPNHSGFLSTPS--NTATSETPTPALRPPSRPQPPPPGNRPRWNASTNTNDLDVGHNFKPLTL 558

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 564388366  282 IPKGPVSSPS-------PRPQPLDTTQVPSPLPLAQPPTPPVRRL 319
Cdd:pfam08580 559 TTPSPTPSRSsrssstlPPVSPLSRDKSRSPAPTCRSVSRASRRR 603
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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