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Conserved domains on  [gi|564371042|ref|XP_006246061|]
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jmjC domain-containing protein 8 isoform X1 [Rattus norvegicus]

Protein Classification

cupin domain-containing protein( domain architecture ID 1562428)

cupin domain-containing protein, part of a functionally diverse superfamily with the active site generally located at the center of a conserved domain forming a beta-barrel fold

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Cupin_8 super family cl46322
Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.
81-274 5.17e-14

Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.


The actual alignment was detected with superfamily member pfam13621:

Pssm-ID: 463936  Cd Length: 251  Bit Score: 70.09  E-value: 5.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371042   81 SEFMQHYAFLKPVILQGLTDNS-----FRALCSRENLLASFGDNVVRLSTAN----------------TYSYQKVdlPFQ 139
Cdd:pfam13621   3 EFFREYVAKNKPVVIRGAVKDWpavqkWTDSSLLDYLKDKYGDVEVTVEVTPdgradrlfynddftfvNPKEERM--PFG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371042  140 EYVEQLlhpQDPESLGNDTLYFFGDNNFTEWAPLFQHYRPPPFR--LLGTTP-AYSFGIAGAGSGVPFHW-HGPGFSEVI 215
Cdd:pfam13621  81 EFLDRL---EAGEDTDTAPYAYLQSDNLRSEFPELLEDNDLPFAteAFGGEPdAVNLWMGNGRSVTSLHYdHYENLYCVV 157
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564371042  216 YGRKRWFLYPPEKTP-------EFHPNKTTLAWL------LEIYPSLAPSARPLECTIQAGEALYFPDRWWH 274
Cdd:pfam13621 158 RGRKRFTLFPPSDVPnlypgplEPTPEGQVFSLVdplapdFERFPRFRDAARPLVVTLNPGDVLYLPALWWH 229
 
Name Accession Description Interval E-value
Cupin_8 pfam13621
Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.
81-274 5.17e-14

Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.


Pssm-ID: 463936  Cd Length: 251  Bit Score: 70.09  E-value: 5.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371042   81 SEFMQHYAFLKPVILQGLTDNS-----FRALCSRENLLASFGDNVVRLSTAN----------------TYSYQKVdlPFQ 139
Cdd:pfam13621   3 EFFREYVAKNKPVVIRGAVKDWpavqkWTDSSLLDYLKDKYGDVEVTVEVTPdgradrlfynddftfvNPKEERM--PFG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371042  140 EYVEQLlhpQDPESLGNDTLYFFGDNNFTEWAPLFQHYRPPPFR--LLGTTP-AYSFGIAGAGSGVPFHW-HGPGFSEVI 215
Cdd:pfam13621  81 EFLDRL---EAGEDTDTAPYAYLQSDNLRSEFPELLEDNDLPFAteAFGGEPdAVNLWMGNGRSVTSLHYdHYENLYCVV 157
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564371042  216 YGRKRWFLYPPEKTP-------EFHPNKTTLAWL------LEIYPSLAPSARPLECTIQAGEALYFPDRWWH 274
Cdd:pfam13621 158 RGRKRFTLFPPSDVPnlypgplEPTPEGQVFSLVdplapdFERFPRFRDAARPLVVTLNPGDVLYLPALWWH 229
RoxA COG2850
Ribosomal protein L16 Arg81 hydroxylase, contains JmjC domain [Translation, ribosomal ...
78-286 5.62e-03

Ribosomal protein L16 Arg81 hydroxylase, contains JmjC domain [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442098  Cd Length: 274  Bit Score: 37.49  E-value: 5.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371042  78 LTYSEFMQHYAFLKP-VILQGLTDnsFRALCSRENL--LASFGDNVVRL-STANTYSYQKVDLPFQEyvEQLlhpqdpES 153
Cdd:COG2850    1 ISPEQFLRDYWQKKPlLIRGAFPD--FVDPLSPDELagLACEEDVESRLvSNDGQGRWQLRHGPFDE--EDF------AA 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371042 154 LGNdtlyffgdnnfTEWAPLFQ---HYRPP------PFRLLGTTP----AYSFgiAGAGSGVPFHW--------HGpgfs 212
Cdd:COG2850   71 LPE-----------RGWTLLVQgvdHWHPEvaallrAFRFIPDWRlddlMISY--APPGGGVGPHFdsydvfllQG---- 133
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564371042 213 eviYGRKRWFLYPPEKTPEFHPNKTTLAWLleiypslapsaRPLECTI----QAGEALYFPDRWWHATLNLDTSVFIS 286
Cdd:COG2850  134 ---EGRRRWRIGDQPDDDPELVPDLPLRIL-----------ADFEPEIdwvlEPGDMLYLPPGFAHDGVALEECMTYS 197
 
Name Accession Description Interval E-value
Cupin_8 pfam13621
Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.
81-274 5.17e-14

Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.


Pssm-ID: 463936  Cd Length: 251  Bit Score: 70.09  E-value: 5.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371042   81 SEFMQHYAFLKPVILQGLTDNS-----FRALCSRENLLASFGDNVVRLSTAN----------------TYSYQKVdlPFQ 139
Cdd:pfam13621   3 EFFREYVAKNKPVVIRGAVKDWpavqkWTDSSLLDYLKDKYGDVEVTVEVTPdgradrlfynddftfvNPKEERM--PFG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371042  140 EYVEQLlhpQDPESLGNDTLYFFGDNNFTEWAPLFQHYRPPPFR--LLGTTP-AYSFGIAGAGSGVPFHW-HGPGFSEVI 215
Cdd:pfam13621  81 EFLDRL---EAGEDTDTAPYAYLQSDNLRSEFPELLEDNDLPFAteAFGGEPdAVNLWMGNGRSVTSLHYdHYENLYCVV 157
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564371042  216 YGRKRWFLYPPEKTP-------EFHPNKTTLAWL------LEIYPSLAPSARPLECTIQAGEALYFPDRWWH 274
Cdd:pfam13621 158 RGRKRFTLFPPSDVPnlypgplEPTPEGQVFSLVdplapdFERFPRFRDAARPLVVTLNPGDVLYLPALWWH 229
JmjC_2 pfam08007
JmjC domain; This entry includes proteins with a JmjC domain that belong to the cupin ...
196-287 6.43e-04

JmjC domain; This entry includes proteins with a JmjC domain that belong to the cupin superfamily, including Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66, Ribosomal oxygenase 1/2, and 50S ribosomal protein L16 3-hydroxylase from Escherichia coli. Proteins are bifunctional, acting as histone lysine demethylases and ribosomal histidine hydroxylases.


Pssm-ID: 462340  Cd Length: 116  Bit Score: 38.77  E-value: 6.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371042  196 AGAGSGVPFHWHgpgFSEV----IYGRKRWFLYPPeKTP--EFHPNKTtlawlleiYPSLAPSARPLECTIQAGEALYFP 269
Cdd:pfam08007  22 ATPGGGVGPHYD---DYDVfllqGEGRKRWRVGAP-KVPdlEFYSDPP--------LRILDDFEPVHDFVLEPGDMLYLP 89
                          90
                  ....*....|....*...
gi 564371042  270 DRWWHATLNLDTSVFIST 287
Cdd:pfam08007  90 RGFIHQGVALDESLHYSV 107
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
199-287 1.28e-03

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


Pssm-ID: 396791  Cd Length: 114  Bit Score: 37.66  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371042  199 GSGVPFHWHGPGFSEVIY----GRKRWFLYPPEK---------------TPEFHPNKTTLAWLLEIYPSLAPsarPLECT 259
Cdd:pfam02373   8 FSTTPWHIEDQGLYSINYlhfgAPKVWYIIPPEYaekfekvlsdhfggeQPDDLLHLNTIISPKQLRENGIP---VYRFV 84
                          90       100
                  ....*....|....*....|....*...
gi 564371042  260 IQAGEALYFPDRWWHATLNLDTSVFIST 287
Cdd:pfam02373  85 QKPGEFVFTFPGWYHQVFNLGFNIAEAV 112
RoxA COG2850
Ribosomal protein L16 Arg81 hydroxylase, contains JmjC domain [Translation, ribosomal ...
78-286 5.62e-03

Ribosomal protein L16 Arg81 hydroxylase, contains JmjC domain [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442098  Cd Length: 274  Bit Score: 37.49  E-value: 5.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371042  78 LTYSEFMQHYAFLKP-VILQGLTDnsFRALCSRENL--LASFGDNVVRL-STANTYSYQKVDLPFQEyvEQLlhpqdpES 153
Cdd:COG2850    1 ISPEQFLRDYWQKKPlLIRGAFPD--FVDPLSPDELagLACEEDVESRLvSNDGQGRWQLRHGPFDE--EDF------AA 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371042 154 LGNdtlyffgdnnfTEWAPLFQ---HYRPP------PFRLLGTTP----AYSFgiAGAGSGVPFHW--------HGpgfs 212
Cdd:COG2850   71 LPE-----------RGWTLLVQgvdHWHPEvaallrAFRFIPDWRlddlMISY--APPGGGVGPHFdsydvfllQG---- 133
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564371042 213 eviYGRKRWFLYPPEKTPEFHPNKTTLAWLleiypslapsaRPLECTI----QAGEALYFPDRWWHATLNLDTSVFIS 286
Cdd:COG2850  134 ---EGRRRWRIGDQPDDDPELVPDLPLRIL-----------ADFEPEIdwvlEPGDMLYLPPGFAHDGVALEECMTYS 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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