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Conserved domains on  [gi|1958801397|ref|XP_006244570|]
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BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X2 [Rattus norvegicus]

Protein Classification

GLTSCR1 domain-containing protein( domain architecture ID 10633660)

GLTSCR1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GLTSCR1 pfam15249
Conserved region of unknown function on GLTSCR protein; This domain family is found in ...
 712-812 2.48e-41

Conserved region of unknown function on GLTSCR protein; This domain family is found in eukaryotes, and is typically between 105 and 124 amino acids in length. It is found on glioma tumour suppressor candidate region gene proteins. ** Forced reload


:

Pssm-ID: 464589 [Multi-domain]  Cd Length: 102  Bit Score: 146.65  E-value: 2.48e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958801397  712 DQAHAVTPD-KSQFRSLTDTVQRLLSYHVCQGSMPTEEDLSKVDSEFEEVATQLLKRTHAMLNKYRSLLLEDAMRINPSA 790
Cdd:pfam15249    1 DQKAVLNPDyKTPFASLEDAVKRLLPYHVFQEPKPDEEDLEKADEEFESVATELLKRFQKMLNKYRRLLLRESMRESPSA 80

                           90       100
                   ....*....|....*....|..
gi 1958801397  791 EMVMIDRMFNQEERASLSRDKR 812
Cdd:pfam15249   81 EMVMLERLFLEEERRELEELKR 102
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 498-670 9.07e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 9.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958801397  498 QMPLQQASPTVLHLSPGQSSVSQGRPGFATMASVSSMSGPARFPAVSSASTAHPTLGPAVQSGASGSNFTGDQLtQANRT 577
Cdd:pfam03154  164 QQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTL-HPQRL 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958801397  578 PVPVSVSHRLPVSASKSPSTLSSTPGTQQQFFCQAPKKCLnQTAP--IPTPIPTS--KTTDSLRQPQIPGLLSTALPGQD 653
Cdd:pfam03154  243 PSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSL-QTGPshMQHPVPPQpfPLTPQSSQSQVPPGPSPAAPGQS 321

                          170
                   ....*....|....*..
gi 1958801397  654 CGSKIMPAPLGTTQPQQ 670
Cdd:pfam03154  322 QQRIHTPPSQSQLQSQQ 338
 
Name Accession Description Interval E-value
GLTSCR1 pfam15249
Conserved region of unknown function on GLTSCR protein; This domain family is found in ...
 712-812 2.48e-41

Conserved region of unknown function on GLTSCR protein; This domain family is found in eukaryotes, and is typically between 105 and 124 amino acids in length. It is found on glioma tumour suppressor candidate region gene proteins. ** Forced reload


Pssm-ID: 464589 [Multi-domain]  Cd Length: 102  Bit Score: 146.65  E-value: 2.48e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958801397  712 DQAHAVTPD-KSQFRSLTDTVQRLLSYHVCQGSMPTEEDLSKVDSEFEEVATQLLKRTHAMLNKYRSLLLEDAMRINPSA 790
Cdd:pfam15249    1 DQKAVLNPDyKTPFASLEDAVKRLLPYHVFQEPKPDEEDLEKADEEFESVATELLKRFQKMLNKYRRLLLRESMRESPSA 80

                           90       100
                   ....*....|....*....|..
gi 1958801397  791 EMVMIDRMFNQEERASLSRDKR 812
Cdd:pfam15249   81 EMVMLERLFLEEERRELEELKR 102
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 498-670 9.07e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 9.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958801397  498 QMPLQQASPTVLHLSPGQSSVSQGRPGFATMASVSSMSGPARFPAVSSASTAHPTLGPAVQSGASGSNFTGDQLtQANRT 577
Cdd:pfam03154  164 QQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTL-HPQRL 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958801397  578 PVPVSVSHRLPVSASKSPSTLSSTPGTQQQFFCQAPKKCLnQTAP--IPTPIPTS--KTTDSLRQPQIPGLLSTALPGQD 653
Cdd:pfam03154  243 PSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSL-QTGPshMQHPVPPQpfPLTPQSSQSQVPPGPSPAAPGQS 321

                          170
                   ....*....|....*..
gi 1958801397  654 CGSKIMPAPLGTTQPQQ 670
Cdd:pfam03154  322 QQRIHTPPSQSQLQSQQ 338
 
Name Accession Description Interval E-value
GLTSCR1 pfam15249
Conserved region of unknown function on GLTSCR protein; This domain family is found in ...
 712-812 2.48e-41

Conserved region of unknown function on GLTSCR protein; This domain family is found in eukaryotes, and is typically between 105 and 124 amino acids in length. It is found on glioma tumour suppressor candidate region gene proteins. ** Forced reload


Pssm-ID: 464589 [Multi-domain]  Cd Length: 102  Bit Score: 146.65  E-value: 2.48e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958801397  712 DQAHAVTPD-KSQFRSLTDTVQRLLSYHVCQGSMPTEEDLSKVDSEFEEVATQLLKRTHAMLNKYRSLLLEDAMRINPSA 790
Cdd:pfam15249    1 DQKAVLNPDyKTPFASLEDAVKRLLPYHVFQEPKPDEEDLEKADEEFESVATELLKRFQKMLNKYRRLLLRESMRESPSA 80

                           90       100
                   ....*....|....*....|..
gi 1958801397  791 EMVMIDRMFNQEERASLSRDKR 812
Cdd:pfam15249   81 EMVMLERLFLEEERRELEELKR 102
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 498-670 9.07e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 9.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958801397  498 QMPLQQASPTVLHLSPGQSSVSQGRPGFATMASVSSMSGPARFPAVSSASTAHPTLGPAVQSGASGSNFTGDQLtQANRT 577
Cdd:pfam03154  164 QQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTL-HPQRL 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958801397  578 PVPVSVSHRLPVSASKSPSTLSSTPGTQQQFFCQAPKKCLnQTAP--IPTPIPTS--KTTDSLRQPQIPGLLSTALPGQD 653
Cdd:pfam03154  243 PSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSL-QTGPshMQHPVPPQpfPLTPQSSQSQVPPGPSPAAPGQS 321

                          170
                   ....*....|....*..
gi 1958801397  654 CGSKIMPAPLGTTQPQQ 670
Cdd:pfam03154  322 QQRIHTPPSQSQLQSQQ 338
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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