BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467   1 MGRLNEQRLFQPDLCDVDLVLVPQHSVFPAHKGVLAAYSQFFHSLFTQNKQLQRVELSLEALAPSGLQQILNFIYTSKLL 80
Cdd:cd18231    1 MDRLNEQRLFQPDLCDVDIVLVRQRSTFPAHKGVLAAYSQFFHSLFTQNKQLQRVELSLEALTSQGLQQILNFIYTSKLL 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 564366467  81 VNAANVHEVLSAASLLQMADIAASCQELLDARSL 114
Cdd:cd18231   81 VNSCNVQDVLNAAAVLQMNDIAASCQELIDSRSL 114

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467 555 GEKPFRCE--NCNERFQYKYQLRSHMsIHiGHkqfmcqwCGKDFNMKQYFDEHMKTHTGEKPYICEICGKSFTSRPNMKR 632
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM-LH-GH-------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416

                 ....*.
gi 564366467 633 HrRTHT 638
Cdd:COG5189  417 H-RKHS 421

FOG: Zn-finger [General function prediction only];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467 503 FSCEICEKKFHTMAHVRKHMVAHTKDMPFTC--ETCGKSFKRSMSLKVHSLQHSGEKPFRCENCNerFQYKYQLRSHMSI 580
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSL--PLSNSKASSSSLS 111

                 ....
gi 564366467 581 HIGH 584
Cdd:COG5048  112 SSSS 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467   1 MGRLNEQRLFQPDLCDVDLVLVPQHSVFPAHKGVLAAYSQFFHSLFTQNKQLQRVELSLEALAPSGLQQILNFIYTSKLL 80
Cdd:cd18231    1 MDRLNEQRLFQPDLCDVDIVLVRQRSTFPAHKGVLAAYSQFFHSLFTQNKQLQRVELSLEALTSQGLQQILNFIYTSKLL 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 564366467  81 VNAANVHEVLSAASLLQMADIAASCQELLDARSL 114
Cdd:cd18231   81 VNSCNVQDVLNAAAVLQMNDIAASCQELIDSRSL 114

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467    18 DLVLVPQHSVFPAHKGVLAAYSQFFHSLFTQN-KQLQRVELSLEALAPSGLQQILNFIYTSKLLVNAANVHEVLSAASLL 96
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDfKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 564366467    97 QMADIAASCQELLDARS 113
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....
gi 564366467  629 NMKRHRRTHTGEKPYPCDVCGQRF 652
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24

PRLI-interacting factor K; Provisional

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564366467 405 DGLGAKVKLEEKQQH-PCQKCPRVFNNRwYLEKHMNVTHSRMQiCGqCGkrFLLESELQL-HRQTDCE-RNIQCMTCG 479
Cdd:PLN03086 439 DGCGIVLRVEEAKNHvHCEKCGQAFQQG-EMEKHMKVFHEPLQ-CP-CG--VVLEKEQMVqHQASTCPlRLITCRFCG 511

FOG: Zn-finger [General function prediction only];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467 503 FSCEICEKKFHTMAHVRKHMVAHTKDMPFTC--ETCGKSFKRSMSLKVHSLQHSGEKPFRCENCNerFQYKYQLRSHMSI 580
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSL--PLSNSKASSSSLS 111

                 ....
gi 564366467 581 HIGH 584
Cdd:COG5048  112 SSSS 115

Transmembrane protein family 171; This family of proteins is found in eukaryotes. TMEM171 is also known as parturition-related protein 2. Proteins in this family are typically between 242 and 326 amino acids in length.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467  131 PVPPPPYYCDIKQEADTPGLPK--IYAREGPDPYSVRVEDGAGAAGDVGSAAAGPAQTLF 188
Cdd:pfam15471 220 PPPPPPYFPESSASAVTPSPGAngLLPSENPPSYYSIFNDGTPTPEDQGTASERDRESIY 279

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467   1 MGRLNEQRLFQPDLCDVDLVLVPQHSVFPAHKGVLAAYSQFFHSLFTQNKQLQRVELSLEALAPSGLQQILNFIYTSKLL 80
Cdd:cd18231    1 MDRLNEQRLFQPDLCDVDIVLVRQRSTFPAHKGVLAAYSQFFHSLFTQNKQLQRVELSLEALTSQGLQQILNFIYTSKLL 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 564366467  81 VNAANVHEVLSAASLLQMADIAASCQELLDARSL 114
Cdd:cd18231   81 VNSCNVQDVLNAAAVLQMNDIAASCQELIDSRSL 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467  14 LCDVdlVLVPQHSVFPAHKGVLAAYSQFFHSLFTQN-KQLQRVELSLEALAPSGLQQILNFIYTSKLLVNAANVHEVLSA 92
Cdd:cd18186    1 LCDV--TLVVGGREFPAHRAVLAARSPYFRAMFSSGmKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAA 78

                 ....
gi 564366467  93 ASLL 96
Cdd:cd18186   79 ADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467  14 LCDVdlVLVPQHSVFPAHKGVLAAYSQFFHSLFTQN-KQLQRVELSLEALAPSGLQQILNFIYTSKLLVNAANVHEVLSA 92
Cdd:cd18255   18 LLDV--TLIADGQRFQAHKVVLASCSDYFRAMFTGGmRESSQDEIELKGVSAKGLKHILDFAYTSELTLDLDCIQDVLGA 95

                         90
                 ....*....|....*..
gi 564366467  93 ASLLQMADIAASCQELL 109
Cdd:cd18255   96 AVHLQMLPVVELCEEFL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467   1 MGRLNEQRLfQPDLCDVdlVLVPQHSVFPAHKGVLAAYSQFFHSLFTQNKQLQRVE--------LSLEALAPSGLQQILN 72
Cdd:cd18228    7 LGKLNSLRN-EGHFCDV--TIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVLvspagkcvLDLHHVTVTGFAPLLE 83

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 564366467  73 FIYTSKLLVNAANVHEVLSAASLLQMADIAASCQELL 109
Cdd:cd18228   84 YAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFM 120

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467    18 DLVLVPQHSVFPAHKGVLAAYSQFFHSLFTQN-KQLQRVELSLEALAPSGLQQILNFIYTSKLLVNAANVHEVLSAASLL 96
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDfKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 564366467    97 QMADIAASCQELLDARS 113
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467   1 MGRLNEQRLfQPDLCDVDLVLVPQHsvFPAHKGVLAAYSQFFHSLFTQNK-QLQRVELSLEALAPSGLQQILNFIYTSKL 79
Cdd:cd18237    9 MGVMNNMRK-QKTLCDVILIVEGRE--IKAHRVVLAAASHFFHLMFTSNMtESKSSEVELKDAEPDIIELLVEFAYTARI 85

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 564366467  80 LVNAANVHEVLSAASLLQMADIAASCQELLdARSLAPS 117
Cdd:cd18237   86 SVNSNNVQSLLDAANQYQIEPVKKMCVDFL-KEQLDAS 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467   4 LNEQRLfQPDLCDVDLVLvpQHSVFPAHKGVLAAYSQFFHSLFTQNKQL--QRVELSLEALAPSGLQQILNFIYTSKLLV 81
Cdd:cd18230   12 LNEQRQ-HGILCDVCIIV--EGKIFKAHKNVLLGSSRYFKTLYCQVQKTsdQATVTHLDIVTAQGFKAIIDFMYSAHLAL 88

                         90       100       110
                 ....*....|....*....|....*....|
gi 564366467  82 NAANVHEVLSAASLLQMADIAASCQELLDA 111
Cdd:cd18230   89 TSKNVIEVMSAASYLQMTDIVQACHNFIKA 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467   3 RLNEQRLfQPDLCDVDLVLvpQHSVFPAHKGVLAAYSQFFHSLFTQNKQ--LQRVELSLEALAPSGLQQILNFIYTSKLL 80
Cdd:cd18329   11 QLDEQRK-QELFCDCSILV--EGQVFKAHRNVLFASSGYFKMLLSQNAKetGQPTVATFDVFSPDTFTIILDFVYSGKLS 87

                         90       100
                 ....*....|....*....|....*.
gi 564366467  81 VNAANVHEVLSAASLLQMADIAASCQ 106
Cdd:cd18329   88 LTSQNVIEVMSAASYLQMTDVISVCK 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467   4 LNEQRLfQPDLCDVdlVLVPQHSVFPAHKGVLAAYSQFFHSLFTQNKQLQRVE-LSLEALAPSGLQQILNFIYTSKLLVN 82
Cdd:cd18235   12 MNELRK-QNLLCDV--ILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANrVTLQDVDGKALLLLIDYVYTAEIQVT 88

                         90       100
                 ....*....|....*....|....*..
gi 564366467  83 AANVHEVLSAASLLQMADIAASCQELL 109
Cdd:cd18235   89 EENVQVLLPAANLLQLTDVRDACCDFL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467   1 MGRLNEQRLfQPDLCDVDLVLvpQHSVFPAHKGVLAAYSQFFHSLFTQNKQ--LQRVELSLEALAPSGLQQILNFIYTSK 78
Cdd:cd18199    6 LGQLNEQRK-QDFFCDCSIIV--EGRIFKAHRNVLFASSGYFRMLLSHYIQdtGRPSTASFDVFSSDAFSIILDFVYSGK 82

                         90       100
                 ....*....|....*....|....*...
gi 564366467  79 LLVNAANVHEVLSAASLLQMADIAASCQ 106
Cdd:cd18199   83 LSLTSQNVIEVMSAASYLQMTDVINVCK 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467   4 LNEQRLFQpDLCDVDLVLVPQHSV--FPAHKGVLAAYSQFFHSLFTQN-KQLQRVELSLEALAPSGLQQILNFIYTSKLL 80
Cdd:cd18248   12 MNELRLSQ-QLCDVTLKVKYQDPKeeFMAHKVVLASSSPYFKAMFTSGlRECGMEVVPIEGVHPCVMSRLIEFAYTASIS 90

                         90       100
                 ....*....|....*....|....*....
gi 564366467  81 VNAANVHEVLSAASLLQMADIAASCQELL 109
Cdd:cd18248   91 VGEKCVLHVLPGAVMYQMDSVVKACCDFL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467  14 LCDVdlVLVPQHSVFPAHKGVLAAYSQFFHSLFTQNKQLQRVE-LSLEALAPSGLQQILNFIYTSKLLVNAANVHEVLSA 92
Cdd:cd18264   28 LCDV--VLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARvIHLPVVSAAGLQRVLDFIYTSWLSLSLDTLEDTLEA 105

                         90       100
                 ....*....|....*....|....
gi 564366467  93 ASLLQMADIAASCQELLdARSLAP 116
Cdd:cd18264  106 ASYLQVTEAIGLCSQYL-INNLAP 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467   3 RLNEQRLFQPDLCD-------VDLVLVPQHSVFPAHKGVLAAYSQFFHSLFTQNKQLQRV-ELSLEALAPSGLQQILNFI 74
Cdd:cd18340    7 RLYQQTLLQDGLKDlldhnkfVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKrEIVLEDVDPDVMGKILHYI 86

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 564366467  75 YTSKLLVNAANVHEVLSAASLLQMADIAASCQELLDAR 112
Cdd:cd18340   87 YTSEIEITEQNVQDIFAAANMFQIPSIFTVCVSFLQKR 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467  14 LCDVDLVLvpQHSVFPAHKGVLAAYSQFFHSLFTQNKQLQRVEL-SLEALAPSGLQQILNFIYTSKLLVNAANVHEVLSA 92
Cdd:cd18238   15 LCDVTLKV--GEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSiTIKDIDEEAVELLVDFAYTGKLTLTVDNVQSLLYA 92

                         90       100
                 ....*....|....*....|....*
gi 564366467  93 ASLLQMADIAASCQELLdARSLAPS 117
Cdd:cd18238   93 ASLLQVEEVAKACCEFM-KDHLHPS 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467  17 VDLVLVPQHSVFPAHKGVLAAYSQFFHSLFT------QNKQLQRVELSLEALApsglqQILNFIYTSKLLVNAANVHEVL 90
Cdd:cd18276   22 TDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTcglmecSQREVVLHDITAESVS-----IILNYMYSSDLHLTNSNVQGVA 96

                         90
                 ....*....|....*.
gi 564366467  91 SAASLLQMADIAASCQ 106
Cdd:cd18276   97 TAAFFLQMEDIFSVCQ 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467   3 RLNEQRLFQPDLCDVdLVLVPQHSvFPAHKGVLAAYSQFFHSLFTQNKQ--LQRVELSLEALAPSGLQQILNFIYTSKLL 80
Cdd:cd18207   16 NLNQQRKSGGRFCDV-LLRVGEES-FPAHRAVLAACSEYFESVFSAQEGdgGTPRELEMHTISSKVFGDILDFAYTSRIV 93

                         90       100
                 ....*....|....*....|....*....
gi 564366467  81 VNAANVHEVLSAASLLQMADIAASCQELL 109
Cdd:cd18207   94 VRLESFPELMTAAKFLLMRSVIDICQEVI 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467   1 MGRLNEQRLfqpdLCDvdLVLVPQHSVFPAHKGVLAAYSQFFHSLFTQNKQLQRVELSleALAPSGLQQILNFIYTSKLL 80
Cdd:cd18260    9 LNRMRQERF----LCD--LTIATKTKSFDVHKVVMASCSEYFRNILKKDPSLQRVELN--DISPLGLATVITYAYTGKLT 80

                         90       100
                 ....*....|....*....|....*....
gi 564366467  81 VNAANVHEVLSAASLLQMADIAASCQELL 109
Cdd:cd18260   81 LSLYTIGSTISAASYLQIHALVKMCCDFL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467   4 LNEQRLfQPDLCDVDLVlVPQHSvFPAHKGVLAAYSQFFHSLFTQNKQlQRVELSlEALAPSGLQQILNFIYTSKLLVNA 83
Cdd:cd18290   18 LNEQRL-QGLYCDVSVV-VKGHA-FKAHRAVLAASSSYFRDLFNSSRS-AVVELP-AAVQPQSFQQILSFCYTGRLSMNV 92

                         90
                 ....*....|....*...
gi 564366467  84 ANVHEVLSAASLLQMADI 101
Cdd:cd18290   93 GDQFLLMYTAGFLQIQEI 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467   3 RLNEQRLFQPDLCD-------VDLVLVPQHSVFPAHKGVLAAYSQFFHSLF-TQNKQLQRVELSLEALAPSGLQQILNFI 74
Cdd:cd18269    7 RLYQQTLLQDGLKDlldenkfVDCVLKIGDKEFPCHRLVLAACSPYFRAMFlSDLEESKKKEVVLEDVDPDVMGMILKYL 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 564366467  75 YTSKLLVNAANVHEVLSAASLLQMADIAASCQELLDARsLAPSGPVAL 122
Cdd:cd18269   87 YTSEIDLNDQNVQDIFALASRFQIPSIFTVCVSYLQKR-LSLSNCLAI 133

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467  14 LCDVDLVLVPQHsvFPAHKGVLAAYSQFFHSLFTQNKQLQRVELSLEALAPSGLQQILNFIYTSKLLVNAANVHEVLSAA 93
Cdd:cd18955    1 LCDVTIVVEDQR--FRAHRAVLAACSDYFLSRVVGQTDGDLVITLPEEVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCA 78

                         90
                 ....*....|....*.
gi 564366467  94 SLLQMADIAASCQELL 109
Cdd:cd18955   79 EFLGVHNIEKACFDFL 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564366467   1 MGRLNEQRLfQPDLCDVDLVLVPQHsvFPAHKGVLAAYSQFFHSLFTQNKQLQRVElsLEALAPSGLQQILNFIYTSKLL 80
Cdd:cd18221    6 LDRLNEQRE-LDQFTDITLIVDGHQ--FKAHKAVLAACSQFFYKFFQDFTQEPLVE--IEGVSNMAFRHLIEFTYTAKLM 80

                         90
                 ....*....|....*....
gi 564366467  81 VNA-ANVHEVLSAASLLQM 98
Cdd:cd18221   81 VQGeEEANDVWKAAEYLQM 99