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Conserved domains on  [gi|564355587|ref|XP_006240026|]
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trafficking protein particle complex subunit 12 isoform X1 [Rattus norvegicus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11469162)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 604-749 2.76e-12

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 64.83  E-value: 2.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587 604 SRLGRVLYSMANCLLLMKDYVLAVNAYLTVIKYYPEQePQLLSGIGRILLQIGDIKTAEKYFQDVekvtqkLDGLQGKIM 683
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDN-PEAFALLGEILLQLGDLDEAIVLLHEA------LELDPDEPE 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564355587 684 VLMNRAFLYLGQNNFAEAHKFFTEILRMDPTNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRH 749
Cdd:COG4783   74 ARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 202-366 2.29e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 2.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587  202 PVCTIFSQATSTSSQPHLFLQDGFESQmvKSPSfSSTSETSAKTPPPMVQPSPSLSTffgDTMSSNSLASDFFDSFTTST 281
Cdd:PHA03247 2882 PVRRLARPAVSRSTESFALPPDQPERP--PQPQ-APPPPQPQPQPPPPPQPQPPPPP---PPRPQPPLAPTTDPAGAGEP 2955

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587  282 FISVSNPNAGS------PVPEKLASLTAPVGEKSPDSTSPSYSTRMDRSESGVSRAALDVPESPKPFSQIQAVFAGSDDP 355
Cdd:PHA03247 2956 SGAVPQPWLGAlvpgrvAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQTLWPPDDTE 3035

                         170
                  ....*....|.
gi 564355587  356 FATALSMSEMD 366
Cdd:PHA03247 3036 DSDADSLFDSD 3046
 
Name Accession Description Interval E-value
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 604-749 2.76e-12

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 64.83  E-value: 2.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587 604 SRLGRVLYSMANCLLLMKDYVLAVNAYLTVIKYYPEQePQLLSGIGRILLQIGDIKTAEKYFQDVekvtqkLDGLQGKIM 683
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDN-PEAFALLGEILLQLGDLDEAIVLLHEA------LELDPDEPE 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564355587 684 VLMNRAFLYLGQNNFAEAHKFFTEILRMDPTNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRH 749
Cdd:COG4783   74 ARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
tol_pal_ybgF TIGR02795
tol-pal system protein YbgF; Members of this protein family are the product of one of seven ...
 600-670 9.71e-06

tol-pal system protein YbgF; Members of this protein family are the product of one of seven genes regularly clustered in operons to encode the proteins of the tol-pal system, which is critical for maintaining the integrity of the bacterial outer membrane. The gene for this periplasmic protein has been designated orf2 and ybgF. All members of the seed alignment were from unique tol-pal gene regions from completed bacterial genomes. The architecture of this protein is a signal sequence, a low-complexity region usually rich in Asn and Gln, a well-conserved region with tandem repeats that resemble the tetratricopeptide (TPR) repeat, involved in protein-protein interaction.


Pssm-ID: 188247 [Multi-domain]  Cd Length: 117  Bit Score: 45.35  E-value: 9.71e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564355587  600 QLWrsrLGRVLYSManclllmKDYVLAVNAYLTVIKYYPEQE--PQLLSGIGRILLQIGDIKTAEKYFQDVEK 670
Cdd:TIGR02795  40 HYW---LGEAYYAQ-------GDYADAAKAFLAVVKKYPKSPkaPDALLKLGMSLQELGDKEKAKATLQQVIK 102
TPR_12 pfam13424
Tetratricopeptide repeat;
644-711 1.24e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.22  E-value: 1.24e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587  644 LLSGIGRILLQIGDIKTAEKYFQDVEKVTQKLDGLQ--GKIMVLMNRAFLYLGQNNFAEAHKFFTEILRM 711
Cdd:pfam13424   5 ALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDhpLTATTLLNLGRLYLELGRYEEALELLERALAL 74
PHA03247 PHA03247
large tegument protein UL36; Provisional
 202-366 2.29e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 2.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587  202 PVCTIFSQATSTSSQPHLFLQDGFESQmvKSPSfSSTSETSAKTPPPMVQPSPSLSTffgDTMSSNSLASDFFDSFTTST 281
Cdd:PHA03247 2882 PVRRLARPAVSRSTESFALPPDQPERP--PQPQ-APPPPQPQPQPPPPPQPQPPPPP---PPRPQPPLAPTTDPAGAGEP 2955

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587  282 FISVSNPNAGS------PVPEKLASLTAPVGEKSPDSTSPSYSTRMDRSESGVSRAALDVPESPKPFSQIQAVFAGSDDP 355
Cdd:PHA03247 2956 SGAVPQPWLGAlvpgrvAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQTLWPPDDTE 3035

                         170
                  ....*....|.
gi 564355587  356 FATALSMSEMD 366
Cdd:PHA03247 3036 DSDADSLFDSD 3046
 
Name Accession Description Interval E-value
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 604-749 2.76e-12

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 64.83  E-value: 2.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587 604 SRLGRVLYSMANCLLLMKDYVLAVNAYLTVIKYYPEQePQLLSGIGRILLQIGDIKTAEKYFQDVekvtqkLDGLQGKIM 683
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDN-PEAFALLGEILLQLGDLDEAIVLLHEA------LELDPDEPE 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564355587 684 VLMNRAFLYLGQNNFAEAHKFFTEILRMDPTNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRH 749
Cdd:COG4783   74 ARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
608-764 6.05e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.57  E-value: 6.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587 608 RVLYSMANCLLLMKDYVLAVNAYLTVIKYYPEqEPQLLSGIGRILLQIGDIKTAEKYFQDVEKVTQKLdglqgkIMVLMN 687
Cdd:COG0457    9 EAYNNLGLAYRRLGRYEEAIEDYEKALELDPD-DAEALYNLGLAYLRLGRYEEALADYEQALELDPDD------AEALNN 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564355587 688 RAFLYLGQNNFAEAHKFFTEILRMDPTNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRHYlheSVLFNLTTMYE 764
Cdd:COG0457   82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDA---DALYNLGIALE 155
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 608-788 8.88e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 63.59  E-value: 8.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587 608 RVLYSMANCLLLMKDYVLAVNAYLTVIKYYPEQePQLLSGIGRILLQIGDIKTAEKYFQDVEKVTQKldglqgKIMVLMN 687
Cdd:COG2956   77 EALLELAQDYLKAGLLDRAEELLEKLLELDPDD-AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPE------NAHAYCE 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587 688 RAFLYLGQNNFAEAHKFFTEILRMDPTNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRHYlheSVLFNLTTMYElES 767
Cdd:COG2956  150 LAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYL---PALPRLAELYE-KL 225

                        170       180
                 ....*....|....*....|.
gi 564355587 768 SRSMQKKQSLLEAVASKEGDS 788
Cdd:COG2956  226 GDPEEALELLRKALELDPSDD 246
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
608-740 1.85e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 61.95  E-value: 1.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587 608 RVLYSMANCLLLMKDYVLAVNAYLTVIKYYPEQePQLLSGIGRILLQIGDIKTAEKYFQdvekvtQKLDGLQGKIMVLMN 687
Cdd:COG0457   43 EALYNLGLAYLRLGRYEEALADYEQALELDPDD-AEALNNLGLALQALGRYEEALEDYD------KALELDPDDAEALYN 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 564355587 688 RAFLYLGQNNFAEAHKFFTEILRMDPTNAVANNNAAVCLLYLGKLKDSLRQLE 740
Cdd:COG0457  116 LGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLE 168
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 607-713 5.99e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 55.01  E-value: 5.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587 607 GRVLYSMANCLLLMKDYVLAVNAYLTVIKYYPEqEPQLLSGIGRILLQIGDIKTAEKYFQDVekvtQKLDGLQgkIMVLM 686
Cdd:COG4235   17 AEGWLLLGRAYLRLGRYDEALAAYEKALRLDPD-NADALLDLAEALLAAGDTEEAEELLERA----LALDPDN--PEALY 89

                         90       100
                 ....*....|....*....|....*..
gi 564355587 687 NRAFLYLGQNNFAEAHKFFTEILRMDP 713
Cdd:COG4235   90 LLGLAAFQQGDYAEAIAAWQKLLALLP 116
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 611-753 4.32e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 55.12  E-value: 4.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587 611 YSMANCLLLMKDYVLAVNAYLTVIKYYPEQePQLLSGIGRILLQIGDIKTAEKYFQDVEKVTQKldglqgKIMVLMNRAF 690
Cdd:COG2956   12 YFKGLNYLLNGQPDKAIDLLEEALELDPET-VEAHLALGNLYRRRGEYDRAIRIHQKLLERDPD------RAEALLELAQ 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564355587 691 LYLGQNNFAEAHKFFTEILRMDPTNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPR--HYLHE 753
Cdd:COG2956   85 DYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPEnaHAYCE 149
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 574-785 1.54e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 55.00  E-value: 1.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587 574 LANLEQGLAEDGGLSSVTQESRQASVQLWRSRLGRVLYSMANCLLLMKDYVLAVNAYLTVIKYYPEqEPQLLSGIGRILL 653
Cdd:COG3914   45 LLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPD-NAEALFNLGNLLL 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587 654 QIGDIKTAEKYFQDVEKVTQKLdglqgkIMVLMNRAFLYLGQNNFAEAHKFFTEILRMDPTNAVANNNAAVCLLYLGKLK 733
Cdd:COG3914  124 ALGRLEEALAALRRALALNPDF------AEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLE 197

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 564355587 734 DSLRQLEAMVQQDPRH-YLHESVLFnltTMYELESSRSMQKKQSLLEAVASKE 785
Cdd:COG3914  198 EAIAAYRRALELDPDNaDAHSNLLF---ALRQACDWEVYDRFEELLAALARGP 247
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 604-670 3.53e-07

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 49.22  E-value: 3.53e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564355587 604 SRLGRVLYSMANCLLLMKDYVLAVNAYLTVIKYYPEQE--PQLLSGIGRILLQIGDIKTAEKYFQDVEK 670
Cdd:COG1729   27 PLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPkaPDALLKLGLSYLELGDYDKARATLEELIK 95
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
651-750 3.96e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 48.63  E-value: 3.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587 651 ILLQIGDIKTAEKYFQDVekvtQKLDGlqGKIMVLMNRAFLYLGQNNFAEAHKFfTEILRMDPTNAVANNNAAVCLLYLG 730
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKA----LELDP--DNADALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAELLLELG 73

                         90       100
                 ....*....|....*....|
gi 564355587 731 KLKDSLRQLEAMVQQDPRHY 750
Cdd:COG3063   74 DYDEALAYLERALELDPSAL 93
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
616-713 1.07e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 47.47  E-value: 1.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587 616 CLLLMKDYVLAVNAYLTVIKYYPEQePQLLSGIGRILLQIGDIKTAEKYFQdvekvTQKLDglQGKIMVLMNRAFLYLGQ 695
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDN-ADALNNLGLLLLEQGRYDEAIALEK-----ALKLD--PNNAEALLNLAELLLEL 72

                         90
                 ....*....|....*...
gi 564355587 696 NNFAEAHKFFTEILRMDP 713
Cdd:COG3063   73 GDYDEALAYLERALELDP 90
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 608-746 1.22e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 50.88  E-value: 1.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587 608 RVLYSMANCLLLMKDYVLAVNAYLTVIKYYPEQEPQLLSgIGRILLQIGDIKTAEKYFQDVEKvtQKLDGLQgkimVLMN 687
Cdd:COG2956  145 HAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLL-LAELYLEQGDYEEAIAALERALE--QDPDYLP----ALPR 217

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564355587 688 RAFLYLGQNNFAEAHKFFTEILRMDPTNAVANNNAAVcLLYLGKLKDSLRQLEAMVQQD 746
Cdd:COG2956  218 LAELYEKLGDPEEALELLRKALELDPSDDLLLALADL-LERKEGLEAALALLERQLRRH 275
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 626-747 1.67e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 48.08  E-value: 1.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587 626 AVNAYLTVIKYYPEQePQLLSGIGRILLQIGDIKTAEKYFQDVekvtQKLDGlqGKIMVLMNRAFLYLGQNNFAEAHKFF 705
Cdd:COG4235    2 AIARLRQALAANPND-AEGWLLLGRAYLRLGRYDEALAAYEKA----LRLDP--DNADALLDLAEALLAAGDTEEAEELL 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 564355587 706 TEILRMDPTNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDP 747
Cdd:COG4235   75 ERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLP 116
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 643-764 1.92e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.88  E-value: 1.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587 643 QLLSGIGRILLQIGDIKTAEKYFQDVekvtqkLDGLQGKIMVLMNRAFLYLGQNNFAEAHKFFTEILRMDPTNAVANNNA 722
Cdd:COG4783    5 EALYALAQALLLAGDYDEAEALLEKA------LELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNL 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 564355587 723 AVCLLYLGKLKDSLRQLEAMVQQDPRHYlheSVLFNLTTMYE 764
Cdd:COG4783   79 GLALLKAGDYDEALALLEKALKLDPEHP---EAYLRLARAYR 117
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
634-764 1.98e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.01  E-value: 1.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587 634 IKYYPEQePQLLSGIGRILLQIGDIKTAEKYFQDVEkvtqKLDglQGKIMVLMNRAFLYLGQNNFAEAHKFFTEILRMDP 713
Cdd:COG0457    1 LELDPDD-AEAYNNLGLAYRRLGRYEEAIEDYEKAL----ELD--PDDAEALYNLGLAYLRLGRYEEALADYEQALELDP 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564355587 714 TNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRHYlheSVLFNLTTMYE 764
Cdd:COG0457   74 DDAEALNNLGLALQALGRYEEALEDYDKALELDPDDA---EALYNLGLALL 121
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 617-713 2.39e-06

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 46.91  E-value: 2.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587 617 LLLMKDYVLAVNAYLTVIKYYPEQE--PQLLSGIGRILLQIGDIKTAEKYFQDVEKV---TQKLDglqgkiMVLMNRAFL 691
Cdd:COG1729    3 LLKAGDYDEAIAAFKAFLKRYPNSPlaPDALYWLGEAYYALGDYDEAAEAFEKLLKRypdSPKAP------DALLKLGLS 76

                         90       100
                 ....*....|....*....|..
gi 564355587 692 YLGQNNFAEAHKFFTEILRMDP 713
Cdd:COG1729   77 YLELGDYDKARATLEELIKKYP 98
tol_pal_ybgF TIGR02795
tol-pal system protein YbgF; Members of this protein family are the product of one of seven ...
 600-670 9.71e-06

tol-pal system protein YbgF; Members of this protein family are the product of one of seven genes regularly clustered in operons to encode the proteins of the tol-pal system, which is critical for maintaining the integrity of the bacterial outer membrane. The gene for this periplasmic protein has been designated orf2 and ybgF. All members of the seed alignment were from unique tol-pal gene regions from completed bacterial genomes. The architecture of this protein is a signal sequence, a low-complexity region usually rich in Asn and Gln, a well-conserved region with tandem repeats that resemble the tetratricopeptide (TPR) repeat, involved in protein-protein interaction.


Pssm-ID: 188247 [Multi-domain]  Cd Length: 117  Bit Score: 45.35  E-value: 9.71e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564355587  600 QLWrsrLGRVLYSManclllmKDYVLAVNAYLTVIKYYPEQE--PQLLSGIGRILLQIGDIKTAEKYFQDVEK 670
Cdd:TIGR02795  40 HYW---LGEAYYAQ-------GDYADAAKAFLAVVKKYPKSPkaPDALLKLGMSLQELGDKEKAKATLQQVIK 102
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 592-747 1.29e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 46.11  E-value: 1.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587 592 QESRQASVQLWRSRLGRVLYSMANCLLLMKDYVLAVNAYLTVIKYYPEQEPQLLSGIGRILLQIGDIKTAEKYFQdvekv 671
Cdd:COG5010    4 LEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLE----- 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564355587 672 tQKLDGLQGKIMVLMNRAFLYLGQNNFAEAHKFFTEILRMDPTNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDP 747
Cdd:COG5010   79 -QALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
574-753 9.88e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 44.52  E-value: 9.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587 574 LANLEQGLAEDGGLSSVTQESRQASVQLWRsRLGRVLYSMANCLLLMKDYVLAVNAYLTVIKYYPEQePQLLSGIGRILL 653
Cdd:COG4785   41 LADLALALAAAALAAAALAAERIDRALALP-DLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDL-AEAYNNRGLAYL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587 654 QIGDIKTAEKYFQDVekvtQKLDglQGKIMVLMNRAFLYLGQNNFAEAHKFFTEILRMDPTNAVANNnaavcLLYLGKLK 733
Cdd:COG4785  119 LLGDYDAALEDFDRA----LELD--PDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERAL-----WLYLAERK 187

                        170       180
                 ....*....|....*....|.
gi 564355587 734 -DSLRQLEAMVQQDPRHYLHE 753
Cdd:COG4785  188 lDPEKALALLLEDWATAYLLQ 208
TPR_12 pfam13424
Tetratricopeptide repeat;
644-711 1.24e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.22  E-value: 1.24e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587  644 LLSGIGRILLQIGDIKTAEKYFQDVEKVTQKLDGLQ--GKIMVLMNRAFLYLGQNNFAEAHKFFTEILRM 711
Cdd:pfam13424   5 ALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDhpLTATTLLNLGRLYLELGRYEEALELLERALAL 74
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
607-675 2.17e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 40.92  E-value: 2.17e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564355587 607 GRVLYSMANCLLLMKDYVLAVnAYLTVIKYYPEQePQLLSGIGRILLQIGDIKTAEKYFQDVEKVTQKL 675
Cdd:COG3063   26 ADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNN-AEALLNLAELLLELGDYDEALAYLERALELDPSA 92
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 685-764 5.22e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 40.76  E-value: 5.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587 685 LMNRAFLYLGQNNFAEAHKFFTEILRMDPTNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRhylHESVLFNLTTMYE 764
Cdd:COG4235   20 WLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPD---NPEALYLLGLAAF 96
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 617-797 7.67e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.15  E-value: 7.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587  617 LLLMKDYVLAVNAYLTVIKYYPEqEPQLLSGIGRILLQIGDIKTAEKYFQDV-EKVTQKLDGLQGKIMVlmnraflYLGQ 695
Cdd:TIGR02917 203 LLSLGNIELALAAYRKAIALRPN-NIAVLLALATILIEAGEFEEAEKHADALlKKAPNSPLAHYLKALV-------DFQK 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587  696 NNFAEAHKFFTEILRMDPTNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRhyLHESVLfnLTTMYELESSRSMQKKQ 775
Cdd:TIGR02917 275 KNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPN--SHQARR--LLASIQLRLGRVDEAIA 350

                         170       180
                  ....*....|....*....|..
gi 564355587  776 SLLEAVASkegDSFNTQCLKLA 797
Cdd:TIGR02917 351 TLSPALGL---DPDDPAALSLL 369
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 684-714 9.85e-04

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 37.12  E-value: 9.85e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 564355587  684 VLMNRAFLYLGQNNFAEAHKFFTEILRMDPT 714
Cdd:pfam07719   3 ALYNLGLAYYKLGDYEEALEAYEKALELDPN 33
PHA03247 PHA03247
large tegument protein UL36; Provisional
 202-366 2.29e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 2.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587  202 PVCTIFSQATSTSSQPHLFLQDGFESQmvKSPSfSSTSETSAKTPPPMVQPSPSLSTffgDTMSSNSLASDFFDSFTTST 281
Cdd:PHA03247 2882 PVRRLARPAVSRSTESFALPPDQPERP--PQPQ-APPPPQPQPQPPPPPQPQPPPPP---PPRPQPPLAPTTDPAGAGEP 2955

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355587  282 FISVSNPNAGS------PVPEKLASLTAPVGEKSPDSTSPSYSTRMDRSESGVSRAALDVPESPKPFSQIQAVFAGSDDP 355
Cdd:PHA03247 2956 SGAVPQPWLGAlvpgrvAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQTLWPPDDTE 3035

                         170
                  ....*....|.
gi 564355587  356 FATALSMSEMD 366
Cdd:PHA03247 3036 DSDADSLFDSD 3046
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 691-765 5.10e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 38.40  E-value: 5.10e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564355587 691 LYLGQNNFAEAHKFFTEILRMDPTNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRhylHESVLFNLTTMYEL 765
Cdd:COG5010   63 LYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPD---NPNAYSNLAALLLS 134
TPR_12 pfam13424
Tetratricopeptide repeat;
608-674 7.98e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 35.83  E-value: 7.98e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564355587  608 RVLYSMANCLLLMKDYVLAVNAYLTVI----KYYPEQEPQL---LSGIGRILLQIGDIKTAEKYFQDVEKVTQK 674
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALeiarRLLGPDHPLTattLLNLGRLYLELGRYEEALELLERALALAEK 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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