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Conserved domains on  [gi|564353732|ref|XP_006239324|]
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transmembrane and coiled-coil domain-containing protein 4 isoform X1 [Rattus norvegicus]

Protein Classification

TMCO4 family protein( domain architecture ID 10526259)

transmembrane and coiled-coil domain-containing 4 (TMCO4) family protein such as mouse TMCO4 which is a multi-pass membrane protein, and yeast Mil1p which is a predicted lipase that binds AP-1 complex subunit Apm2 and contributes to its membrane recruitment during cargo protein sorting in clathrin-coated vesicles; belongs to the alpha/beta hydrolase superfamily

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
SCOP:  3000102

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF726 pfam05277
Protein of unknown function (DUF726); This family consists of several uncharacterized ...
218-518 4.00e-160

Protein of unknown function (DUF726); This family consists of several uncharacterized eukaryotic proteins.


:

Pssm-ID: 368366  Cd Length: 341  Bit Score: 462.63  E-value: 4.00e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564353732  218 TIIGSAGAAA-LGSVAGIAVMTSLFGAAGAGLTGYKMKKRVGAIEEFMFLPLTEGKQLHITIAITGWLGSGRYRTFNAPW 296
Cdd:pfam05277  40 GGFGLGGSAGfLASTGGSAVITALFGAAGAGLTGYKMSKRVGAIKTFEFIPLSGNRSLSLTVTVSGWGELGDEDDVTNPW 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564353732  297 MALARS-QEQYCLAWEAKYLMELGNALETIL-SGLANMVAQEALKYTVLSGIVAALTLPASLLSVANVIDNPWGVCLHRS 374
Cdd:pfam05277 120 RALDPNcGDLYALKWEVEYLKELGNALETILaSEAFSMAKQEILGRTVLTSLVAALTWPLALLKVGSILDNPWNVCLDRA 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564353732  375 AEVGKHLAHILLSRQQGRRPVTLIGFSLGARVIYFCLQEMAQEqDCQGIIEDVVLLGAPVEGDPKYWEPFRNVVSGRIIN 454
Cdd:pfam05277 200 AKAGEILADALCSRAHGQRPVTLIGFSLGARVIFYCLLELAKR-KAFGIIENVILMGTPATTSAKVWEKMRSVVSGRFVN 278
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564353732  455 GYCRGDWLLSFVYRTSSVQLRVAGLQPVLLQDrRMENVDLSSVVNGHLDYAKKMDVILKAVGIR 518
Cdd:pfam05277 279 GYSENDWLLGFLYRTMSAQFRVAGLGPIENVP-GIENVDVSGIVSGHLDYRKLMPKILKAIGFE 341
 
Name Accession Description Interval E-value
DUF726 pfam05277
Protein of unknown function (DUF726); This family consists of several uncharacterized ...
218-518 4.00e-160

Protein of unknown function (DUF726); This family consists of several uncharacterized eukaryotic proteins.


Pssm-ID: 368366  Cd Length: 341  Bit Score: 462.63  E-value: 4.00e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564353732  218 TIIGSAGAAA-LGSVAGIAVMTSLFGAAGAGLTGYKMKKRVGAIEEFMFLPLTEGKQLHITIAITGWLGSGRYRTFNAPW 296
Cdd:pfam05277  40 GGFGLGGSAGfLASTGGSAVITALFGAAGAGLTGYKMSKRVGAIKTFEFIPLSGNRSLSLTVTVSGWGELGDEDDVTNPW 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564353732  297 MALARS-QEQYCLAWEAKYLMELGNALETIL-SGLANMVAQEALKYTVLSGIVAALTLPASLLSVANVIDNPWGVCLHRS 374
Cdd:pfam05277 120 RALDPNcGDLYALKWEVEYLKELGNALETILaSEAFSMAKQEILGRTVLTSLVAALTWPLALLKVGSILDNPWNVCLDRA 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564353732  375 AEVGKHLAHILLSRQQGRRPVTLIGFSLGARVIYFCLQEMAQEqDCQGIIEDVVLLGAPVEGDPKYWEPFRNVVSGRIIN 454
Cdd:pfam05277 200 AKAGEILADALCSRAHGQRPVTLIGFSLGARVIFYCLLELAKR-KAFGIIENVILMGTPATTSAKVWEKMRSVVSGRFVN 278
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564353732  455 GYCRGDWLLSFVYRTSSVQLRVAGLQPVLLQDrRMENVDLSSVVNGHLDYAKKMDVILKAVGIR 518
Cdd:pfam05277 279 GYSENDWLLGFLYRTMSAQFRVAGLGPIENVP-GIENVDVSGIVSGHLDYRKLMPKILKAIGFE 341
 
Name Accession Description Interval E-value
DUF726 pfam05277
Protein of unknown function (DUF726); This family consists of several uncharacterized ...
218-518 4.00e-160

Protein of unknown function (DUF726); This family consists of several uncharacterized eukaryotic proteins.


Pssm-ID: 368366  Cd Length: 341  Bit Score: 462.63  E-value: 4.00e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564353732  218 TIIGSAGAAA-LGSVAGIAVMTSLFGAAGAGLTGYKMKKRVGAIEEFMFLPLTEGKQLHITIAITGWLGSGRYRTFNAPW 296
Cdd:pfam05277  40 GGFGLGGSAGfLASTGGSAVITALFGAAGAGLTGYKMSKRVGAIKTFEFIPLSGNRSLSLTVTVSGWGELGDEDDVTNPW 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564353732  297 MALARS-QEQYCLAWEAKYLMELGNALETIL-SGLANMVAQEALKYTVLSGIVAALTLPASLLSVANVIDNPWGVCLHRS 374
Cdd:pfam05277 120 RALDPNcGDLYALKWEVEYLKELGNALETILaSEAFSMAKQEILGRTVLTSLVAALTWPLALLKVGSILDNPWNVCLDRA 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564353732  375 AEVGKHLAHILLSRQQGRRPVTLIGFSLGARVIYFCLQEMAQEqDCQGIIEDVVLLGAPVEGDPKYWEPFRNVVSGRIIN 454
Cdd:pfam05277 200 AKAGEILADALCSRAHGQRPVTLIGFSLGARVIFYCLLELAKR-KAFGIIENVILMGTPATTSAKVWEKMRSVVSGRFVN 278
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564353732  455 GYCRGDWLLSFVYRTSSVQLRVAGLQPVLLQDrRMENVDLSSVVNGHLDYAKKMDVILKAVGIR 518
Cdd:pfam05277 279 GYSENDWLLGFLYRTMSAQFRVAGLGPIENVP-GIENVDVSGIVSGHLDYRKLMPKILKAIGFE 341
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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