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Conserved domains on  [gi|564335289|ref|XP_006232011|]
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phospholipid phosphatase 1 isoform X1 [Rattus norvegicus]

Protein Classification

PAP2 phosphatase family protein( domain architecture ID 10130187)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to phospholipid phosphatase that catalyzes the conversion of phosphatidic acid to diacylglycerol

CATH:  1.20.144.10
EC:  3.1.3.-
Gene Ontology:  GO:0042577|GO:0046839|GO:0008610
PubMed:  9122162|12447906|9260289
SCOP:  3001110|4001226

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 99-244 1.35e-71

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


:

Pssm-ID: 239479  Cd Length: 150  Bit Score: 217.11  E-value: 1.35e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335289  99 IYKAVGAFLFGASASQSLTDIAKYSIGRLRPHFLAVCNPDWSKINCS---DGYIENFVCQGNEQKVREGRLSFYSGHSSF 175
Cdd:cd03384    2 LYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSldhQYIADCTCCTGDPDLIREARLSFPSGHASL 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564335289 176 SMYCMLFVALYLQARMKGDWARLLRPMLQFGLVALSIYVGLSRVSDYKHHWSDVLIGLIQGAVVAILVV 244
Cdd:cd03384   82 SMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 99-244 1.35e-71

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 217.11  E-value: 1.35e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335289  99 IYKAVGAFLFGASASQSLTDIAKYSIGRLRPHFLAVCNPDWSKINCS---DGYIENFVCQGNEQKVREGRLSFYSGHSSF 175
Cdd:cd03384    2 LYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSldhQYIADCTCCTGDPDLIREARLSFPSGHASL 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564335289 176 SMYCMLFVALYLQARMKGDWARLLRPMLQFGLVALSIYVGLSRVSDYKHHWSDVLIGLIQGAVVAILVV 244
Cdd:cd03384   82 SMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
acidPPc smart00014
Acid phosphatase homologues;
107-244 2.51e-27

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 102.42  E-value: 2.51e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335289   107 LFGASASQSLTDIAKYSIGRLRPHFLavcnpdWSKINCsdgyienfvCQGNEQKVREGRLSFYSGHSSFSMYCMLFVALY 186
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFL------SIGDAC---------CTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLY 65

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 564335289   187 LqarmkgdWARLLRPMLQFGLVALSIYVGLSRVSDYKHHWSDVLIGLIQGAVVAILVV 244
Cdd:smart00014  66 L-------PARAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PLN02250 PLN02250
lipid phosphate phosphatase
 27-245 4.48e-24

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 98.85  E-value: 4.48e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335289  27 VNLGQIYPFQRgFFCSD--NSVKYPYHDSTVTTSVLVLVGLGIPIFSMItgetlsVYFnvlhsnsFVSNHyIATIYKAVG 104
Cdd:PLN02250  37 VVLNVIEPFHR-FVGKDmlTDLSYPLQDNTIPFWAVPLIAILLPFAVIL------VYY-------FIRRD-VYDLHHAIL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335289 105 AFLFGASASQSLTDIAKYSIGRLRPHFLAVCNPDWSKIncSDGYIENFVCQGNEQKVREGRLSFYSGHSSFSMYCMLFVA 184
Cdd:PLN02250 102 GLLFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGV--FHPVTTDVLCTGAKSVIKEGHKSFPSGHTSWSFAGLGFLS 179

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564335289 185 LYLQARM-----KGDWARLLRPMLQFGLVALsiyVGLSRVSDYKHHWSDVLIGLIQGAVVAILVVL 245
Cdd:PLN02250 180 LYLSGKIrvfdrRGHVAKLCIVFLPLLVAAL---VGVSRVDDYWHHWQDVFAGALIGLTVASFCYL 242
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 105-247 7.39e-21

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 85.55  E-value: 7.39e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335289  105 AFLFGASASQSLTDIAKYSIGRLRPHFLAVCNPDWSkincsdgyienfvcqgNEQKVREGRLSFYSGHSSFSMYCMLFVA 184
Cdd:pfam01569   1 ILLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVP----------------APSTLPGLGYSFPSGHSATAFALALLLA 64

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564335289  185 LYLqarmkGDWARLLRPMLQFGLVALSIYVGLSRVSDYKHHWSDVLIGLIQGAVVAILVVLYV 247
Cdd:pfam01569  65 LLL-----RRLRKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 102-247 2.96e-07

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 49.65  E-value: 2.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335289 102 AVGAFLFGASASQSLTDIAKYSIGRLRPHFLAVCNPDwskINCSDGYienfvcqgneqkvregrlSFYSGHSSFSMYCML 181
Cdd:COG0671   74 LLLLAALLLLLLLLLLLLLKYLFGRPRPFVVPDLELL---LGTAGGY------------------SFPSGHAAAAFALAL 132

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564335289 182 FVALYLQARmkgdWARLLrpmlqfgLVALSIYVGLSRVSDYKHHWSDVLIGLIQGAVVAILVVLYV 247
Cdd:COG0671  133 VLALLLPRR----WLAAL-------LLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLALL 187
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 99-244 1.35e-71

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 217.11  E-value: 1.35e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335289  99 IYKAVGAFLFGASASQSLTDIAKYSIGRLRPHFLAVCNPDWSKINCS---DGYIENFVCQGNEQKVREGRLSFYSGHSSF 175
Cdd:cd03384    2 LYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSldhQYIADCTCCTGDPDLIREARLSFPSGHASL 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564335289 176 SMYCMLFVALYLQARMKGDWARLLRPMLQFGLVALSIYVGLSRVSDYKHHWSDVLIGLIQGAVVAILVV 244
Cdd:cd03384   82 SMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 45-247 2.00e-37

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 131.19  E-value: 2.00e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335289  45 SVKYPYHDS-TVTTSVLVLVGLGIPIFSMITGetlsvyfnvlhsnSFVSNHYIATIYKAVGAFLFGASASQSLTDIAKYS 123
Cdd:cd03390    2 SISYPFAESeTVPTWLLVIISVGIPLLVIILI-------------SLFFRRSLWDLHTSLLGLLLSVSLNGVITNVLKNY 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335289 124 IGRLRPHFLAVCNPDwsKINCSDGYIENFVC-QGNEQKVREGRLSFYSGHSSFSMYCMLFVALYLQARMK--GDWARLLR 200
Cdd:cd03390   69 AGRPRPDFLARCFPD--GGTPSDTLVGIDICcTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHifDPRGSSWR 146

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 564335289 201 PMLQFGLVALSIYVGLSRVSDYKHHWSDVLIGLIQGAVVAILVVLYV 247
Cdd:cd03390  147 LLLALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQY 193
acidPPc smart00014
Acid phosphatase homologues;
107-244 2.51e-27

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 102.42  E-value: 2.51e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335289   107 LFGASASQSLTDIAKYSIGRLRPHFLavcnpdWSKINCsdgyienfvCQGNEQKVREGRLSFYSGHSSFSMYCMLFVALY 186
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFL------SIGDAC---------CTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLY 65

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 564335289   187 LqarmkgdWARLLRPMLQFGLVALSIYVGLSRVSDYKHHWSDVLIGLIQGAVVAILVV 244
Cdd:smart00014  66 L-------PARAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PLN02250 PLN02250
lipid phosphate phosphatase
 27-245 4.48e-24

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 98.85  E-value: 4.48e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335289  27 VNLGQIYPFQRgFFCSD--NSVKYPYHDSTVTTSVLVLVGLGIPIFSMItgetlsVYFnvlhsnsFVSNHyIATIYKAVG 104
Cdd:PLN02250  37 VVLNVIEPFHR-FVGKDmlTDLSYPLQDNTIPFWAVPLIAILLPFAVIL------VYY-------FIRRD-VYDLHHAIL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335289 105 AFLFGASASQSLTDIAKYSIGRLRPHFLAVCNPDWSKIncSDGYIENFVCQGNEQKVREGRLSFYSGHSSFSMYCMLFVA 184
Cdd:PLN02250 102 GLLFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGV--FHPVTTDVLCTGAKSVIKEGHKSFPSGHTSWSFAGLGFLS 179

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564335289 185 LYLQARM-----KGDWARLLRPMLQFGLVALsiyVGLSRVSDYKHHWSDVLIGLIQGAVVAILVVL 245
Cdd:PLN02250 180 LYLSGKIrvfdrRGHVAKLCIVFLPLLVAAL---VGVSRVDDYWHHWQDVFAGALIGLTVASFCYL 242
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 100-244 5.21e-24

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 93.68  E-value: 5.21e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335289 100 YKAVGAFLFGASASQSLTDIAKYSIGRLRPHFLAVCNPDwskincsdgyienfvcqGNEQKVREGRLSFYSGHSSFSMYC 179
Cdd:cd01610    2 RLLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPD-----------------GDPLLLTEGGYSFPSGHAAFAFAL 64

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564335289 180 MLFVALYLqarmkgdWARLLRPMLQFGLVALSIYVGLSRVSDYKHHWSDVLIGLIQGAVVAILVV 244
Cdd:cd01610   65 ALFLALLL-------PRRLLRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
PLN02715 PLN02715
lipid phosphate phosphatase
 14-240 1.13e-21

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 92.42  E-value: 1.13e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335289  14 VICVLLASMPmavVNLGQIYPFQRgFFCSD--NSVKYPYHDSTVTTsvlvlvgLGIPIFSMITGETLSVYFnvlhsnsFV 91
Cdd:PLN02715  52 IILVILIAIE---IGLNLISPFYR-YVGKDmmTDLKYPFKDNTVPI-------WSVPVYAVLLPIILFVCF-------YL 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335289  92 SNHYIATIYKAVGAFLFGASASQSLTDIAKYSIGRLRPHFLAVCNPDWSKINCSDGYIenfVCQGNEQKVREGRLSFYSG 171
Cdd:PLN02715 114 KRRCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELYDALGGV---ICHGKAAEVKEGHKSFPSG 190

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564335289 172 HSSFSMYCMLFVALYLQARMK-----GDWARLLrpMLQFGLVALSIyVGLSRVSDYKHHWSDVLIGLIQGAVVA 240
Cdd:PLN02715 191 HTSWSFAGLTFLSLYLSGKIKafngeGHVAKLC--LVIFPLLAACL-VGISRVDDYWHHWQDVFAGALIGILVA 261
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 105-247 7.39e-21

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 85.55  E-value: 7.39e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335289  105 AFLFGASASQSLTDIAKYSIGRLRPHFLAVCNPDWSkincsdgyienfvcqgNEQKVREGRLSFYSGHSSFSMYCMLFVA 184
Cdd:pfam01569   1 ILLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVP----------------APSTLPGLGYSFPSGHSATAFALALLLA 64

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564335289  185 LYLqarmkGDWARLLRPMLQFGLVALSIYVGLSRVSDYKHHWSDVLIGLIQGAVVAILVVLYV 247
Cdd:pfam01569  65 LLL-----RRLRKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 32-236 1.68e-20

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 89.32  E-value: 1.68e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335289  32 IYPFQRgFFCSD--NSVKYPYHDSTVTTsvlvlvgLGIPIFSMITGETLSVYFnvlhsnsFVSNHYIATIYKAVGAFLFG 109
Cdd:PLN02731  61 IHPFYR-FVGKDmmTDLSYPLKSNTVPI-------WSVPVYAMLLPLVIFIFI-------YFRRRDVYDLHHAVLGLLYS 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335289 110 ASASQSLTDIAKYSIGRLRPHFLAVCNPDWSKINCSDGyieNFVCQGNEQKVREGRLSFYSGHSSFSMYCMLFVALYLQA 189
Cdd:PLN02731 126 VLVTAVLTDAIKNAVGRPRPDFFWRCFPDGKALYDSLG---DVICHGDKSVIREGHKSFPSGHTSWSFSGLGFLSLYLSG 202

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564335289 190 RM-----KGDWARLLRPMLQFGLVALsiyVGLSRVSDYKHHWSDVLIGLIQG 236
Cdd:PLN02731 203 KIqafdgKGHVAKLCIVILPLLFAAL---VGISRVDDYWHHWQDVFAGGLLG 251
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 104-248 2.55e-11

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 59.27  E-value: 2.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335289 104 GAFLFGASASQSLTDIAKYSIGRLRPhflavcnpdwskincsDGYienfvcqgneqkvREGRLSFYSGHSS--FSmycml 181
Cdd:cd03394    6 LILAEAAALTAAVTEGLKFAVGRARP----------------DGS-------------NNGYRSFPSGHTAsaFA----- 51

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564335289 182 fVALYLQARMKGDWArllrpmlQFGLVALSIYVGLSRVSDYKHHWSDVLIgliqGAVVAILVVLYVT 248
Cdd:cd03394   52 -AATFLQYRYGWRWY-------GIPAYALASLVGASRVVANRHWLSDVLA----GAAIGILVGYLVT 106
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 102-247 2.96e-07

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 49.65  E-value: 2.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335289 102 AVGAFLFGASASQSLTDIAKYSIGRLRPHFLAVCNPDwskINCSDGYienfvcqgneqkvregrlSFYSGHSSFSMYCML 181
Cdd:COG0671   74 LLLLAALLLLLLLLLLLLLKYLFGRPRPFVVPDLELL---LGTAGGY------------------SFPSGHAAAAFALAL 132

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564335289 182 FVALYLQARmkgdWARLLrpmlqfgLVALSIYVGLSRVSDYKHHWSDVLIGLIQGAVVAILVVLYV 247
Cdd:COG0671  133 VLALLLPRR----WLAAL-------LLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLALL 187
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 170-242 1.27e-05

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 44.57  E-value: 1.27e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564335289 170 SGHSSFSMYCMLFVALYLQARMKGDWARLLRPMLQFGLVALSIYVGLSRVSDYKHHWSDVLIGLIQGAVVAIL 242
Cdd:cd03382   85 SSHSQFMGFFAVYLLLFIYLRLGRLNSLVSRFLLSLGLLLLALLVSYSRVYLGYHTVSQVVVGAIVGILLGIL 157
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 103-247 4.01e-05

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 43.46  E-value: 4.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335289 103 VGAFLFGASASQSL-TDIAKYSIGRLRPHFLAvcnpdwskincSDG-YIENFVCQGNEQkvregrLSFYSGHSS--FSMy 178
Cdd:cd03389   70 AGLFLFATVALSGIlVNLLKFIIGRARPKLLF-----------DDGlYGFDPFHADYAF------TSFPSGHSAtaGAA- 131

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564335289 179 cmlFVALYLqarmkgdwarlLRPMLQFGLVALSIYVGLSRVSDYKHHWSDVLIGLIQGAVVAILVVLYV 247
Cdd:cd03389  132 ---AAALAL-----------LFPRYRWAFILLALLIAFSRVIVGAHYPSDVIAGSLLGAVTALALYQRF 186
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 103-245 1.99e-04

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 41.10  E-value: 1.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335289 103 VGAFLFGAS-ASQSLTDIAKYSIGRLRPHFLAVCNPDWSKINCSDGYienfvcqgneqkvregrlSFYSGHSSFSMYCML 181
Cdd:cd03395   58 LLLVLLAVGfADQLASGFLKPLVARLRPCNALDGVRLVVLGDQGGSY------------------SFASSHAANSFALAL 119

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564335289 182 FVALYLqarmkgdWARLLRPMLqfglVALSIYVGLSRVSDYKHHWSDVLIGLIQGAVVAILVVL 245
Cdd:cd03395  120 FIWLFF-------RRGLFSPVL----LLWALLVGYSRVYVGVHYPGDVIAGALIGIISGLLFYL 172
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 167-243 8.02e-03

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 36.14  E-value: 8.02e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564335289 167 SFYSGHSSFSMYCMLFVALYLqarmkgDWARLLRPMLqfglVALSIYVGLSRVSDYKHHWSDVLIGLIQGAVVAILV 243
Cdd:cd03391   92 SFPSGHASRAAFVARFLLNHL------VLAVPLRVLL----VLWATVVGISRVLLGRHHVLDVLAGAFLGYLEALLV 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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