NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|564331709|ref|XP_006230602|]
View 

interferon regulatory factor 7 isoform X1 [Rattus norvegicus]

Protein Classification

IRF and IRF-3 domain-containing protein( domain architecture ID 10457094)

IRF and IRF-3 domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 11-121 2.76e-46

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


:

Pssm-ID: 459863  Cd Length: 106  Bit Score: 155.80  E-value: 2.76e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564331709   11 LFGDWLLGEVSSGRYEGLQWLNEAHTVFRVPWKHFSRRDLD-EADAQIFKAWAVARGRWPPsGVNLPPPeaeaaerRGWK 89
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNqEEDAAIFKAWAVHTGKYRE-GVDKPDP-------ATWK 72

                          90       100       110
                  ....*....|....*....|....*....|...
gi 564331709   90 TNFRCALRSTGRFILRQDNS-GDPADPHKVYEL 121
Cdd:pfam00605  73 TNFRCALNKLPDFEEVKDRSkDDGSDPYKVYRI 105
IRF-3 super family cl11061
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 241-418 4.33e-43

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


The actual alignment was detected with superfamily member pfam10401:

Pssm-ID: 463076  Cd Length: 180  Bit Score: 149.71  E-value: 4.33e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564331709  241 LDVTIMYKGRTVLQAMVGHPR-CVFLYSPVGSAIRTSEP---QPVIFPSPAELPDQKQLHYTETLLQHVSPGLQLELRGP 316
Cdd:pfam10401   4 LEITFFYRGRLVLELTVSSPEgCRLSYGPPDPQVALYGPvalQQVRFPDPDGIPDERQREYTRRLLNVLERGLLLWVAGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564331709  317 SLWALRMGKCKVYWEVGSPMGSTNPStpaqLLERNCHTPIFDFSTFFRELEEFRARRRQgSPHYTIYLGFGQDLSAGRPK 396
Cdd:pfam10401  84 GLYAKRLCQSRVFWSGPEAPGGDKPN----KLERDATVKLFDLAKFLRELILFQEGRGR-SPDYTITLCFGEEWPDDKPR 158

                         170       180
                  ....*....|....*....|..
gi 564331709  397 EKSLILVKLEPWLCKTHLEGVQ 418
Cdd:pfam10401 159 EKKLITVQVVPLFARQLLEMAS 180
 
Name Accession Description Interval E-value
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 11-121 2.76e-46

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


Pssm-ID: 459863  Cd Length: 106  Bit Score: 155.80  E-value: 2.76e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564331709   11 LFGDWLLGEVSSGRYEGLQWLNEAHTVFRVPWKHFSRRDLD-EADAQIFKAWAVARGRWPPsGVNLPPPeaeaaerRGWK 89
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNqEEDAAIFKAWAVHTGKYRE-GVDKPDP-------ATWK 72

                          90       100       110
                  ....*....|....*....|....*....|...
gi 564331709   90 TNFRCALRSTGRFILRQDNS-GDPADPHKVYEL 121
Cdd:pfam00605  73 TNFRCALNKLPDFEEVKDRSkDDGSDPYKVYRI 105
IRF smart00348
interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad ...
 12-124 2.04e-44

interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad repeat


Pssm-ID: 128642  Cd Length: 107  Bit Score: 150.95  E-value: 2.04e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564331709    12 FGDWLLGEVSSGRYEGLQWLNEAHTVFRVPWKHFSRRDLD-EADAQIFKAWAVARGRWPPSGVNLPPpeaeaaerRGWKT 90
Cdd:smart00348   2 LRPWLVEQVESGQYPGLCWEDEEKTRFRIPWKHAGRSGFDeERDAEIFKAYCVARGIYQPGGRSPDP--------KTWKA 73

                           90       100       110
                   ....*....|....*....|....*....|....
gi 564331709    91 NFRCALRSTGRFILRQDNSGDPADPHKVYELSPE 124
Cdd:smart00348  74 RLRCALRKSRDFEEIKDASTDPPDPYRVYRLLPE 107
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 241-418 4.33e-43

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


Pssm-ID: 463076  Cd Length: 180  Bit Score: 149.71  E-value: 4.33e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564331709  241 LDVTIMYKGRTVLQAMVGHPR-CVFLYSPVGSAIRTSEP---QPVIFPSPAELPDQKQLHYTETLLQHVSPGLQLELRGP 316
Cdd:pfam10401   4 LEITFFYRGRLVLELTVSSPEgCRLSYGPPDPQVALYGPvalQQVRFPDPDGIPDERQREYTRRLLNVLERGLLLWVAGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564331709  317 SLWALRMGKCKVYWEVGSPMGSTNPStpaqLLERNCHTPIFDFSTFFRELEEFRARRRQgSPHYTIYLGFGQDLSAGRPK 396
Cdd:pfam10401  84 GLYAKRLCQSRVFWSGPEAPGGDKPN----KLERDATVKLFDLAKFLRELILFQEGRGR-SPDYTITLCFGEEWPDDKPR 158

                         170       180
                  ....*....|....*....|..
gi 564331709  397 EKSLILVKLEPWLCKTHLEGVQ 418
Cdd:pfam10401 159 EKKLITVQVVPLFARQLLEMAS 180
IRF cd00103
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ...
 9-123 2.54e-36

Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation.


Pssm-ID: 238051  Cd Length: 107  Bit Score: 129.33  E-value: 2.54e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564331709   9 RVLFGDWLLGEVSSGRYEGLQWLNEAHTVFRVPWKHFSRRDLDEADAQIFKAWAVARGRWPPSGvnlpppeaeAAERRGW 88
Cdd:cd00103    1 KMRLRPWLVEQVDSGTYPGLIWLDEEKTIFRIPWKHAARHDVQEADAKIFKAWAVERGIYQPGG---------TPDPAEW 71

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 564331709  89 KTNFRCALRSTGRFILRQDNSGD-PADPHKVYELSP 123
Cdd:cd00103   72 KARLLCALRSSRGFEEVKDKSKDtPGDPHRVYRLLP 107
 
Name Accession Description Interval E-value
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 11-121 2.76e-46

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


Pssm-ID: 459863  Cd Length: 106  Bit Score: 155.80  E-value: 2.76e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564331709   11 LFGDWLLGEVSSGRYEGLQWLNEAHTVFRVPWKHFSRRDLD-EADAQIFKAWAVARGRWPPsGVNLPPPeaeaaerRGWK 89
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNqEEDAAIFKAWAVHTGKYRE-GVDKPDP-------ATWK 72

                          90       100       110
                  ....*....|....*....|....*....|...
gi 564331709   90 TNFRCALRSTGRFILRQDNS-GDPADPHKVYEL 121
Cdd:pfam00605  73 TNFRCALNKLPDFEEVKDRSkDDGSDPYKVYRI 105
IRF smart00348
interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad ...
 12-124 2.04e-44

interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad repeat


Pssm-ID: 128642  Cd Length: 107  Bit Score: 150.95  E-value: 2.04e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564331709    12 FGDWLLGEVSSGRYEGLQWLNEAHTVFRVPWKHFSRRDLD-EADAQIFKAWAVARGRWPPSGVNLPPpeaeaaerRGWKT 90
Cdd:smart00348   2 LRPWLVEQVESGQYPGLCWEDEEKTRFRIPWKHAGRSGFDeERDAEIFKAYCVARGIYQPGGRSPDP--------KTWKA 73

                           90       100       110
                   ....*....|....*....|....*....|....
gi 564331709    91 NFRCALRSTGRFILRQDNSGDPADPHKVYELSPE 124
Cdd:smart00348  74 RLRCALRKSRDFEEIKDASTDPPDPYRVYRLLPE 107
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 241-418 4.33e-43

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


Pssm-ID: 463076  Cd Length: 180  Bit Score: 149.71  E-value: 4.33e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564331709  241 LDVTIMYKGRTVLQAMVGHPR-CVFLYSPVGSAIRTSEP---QPVIFPSPAELPDQKQLHYTETLLQHVSPGLQLELRGP 316
Cdd:pfam10401   4 LEITFFYRGRLVLELTVSSPEgCRLSYGPPDPQVALYGPvalQQVRFPDPDGIPDERQREYTRRLLNVLERGLLLWVAGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564331709  317 SLWALRMGKCKVYWEVGSPMGSTNPStpaqLLERNCHTPIFDFSTFFRELEEFRARRRQgSPHYTIYLGFGQDLSAGRPK 396
Cdd:pfam10401  84 GLYAKRLCQSRVFWSGPEAPGGDKPN----KLERDATVKLFDLAKFLRELILFQEGRGR-SPDYTITLCFGEEWPDDKPR 158

                         170       180
                  ....*....|....*....|..
gi 564331709  397 EKSLILVKLEPWLCKTHLEGVQ 418
Cdd:pfam10401 159 EKKLITVQVVPLFARQLLEMAS 180
IRF cd00103
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ...
 9-123 2.54e-36

Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation.


Pssm-ID: 238051  Cd Length: 107  Bit Score: 129.33  E-value: 2.54e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564331709   9 RVLFGDWLLGEVSSGRYEGLQWLNEAHTVFRVPWKHFSRRDLDEADAQIFKAWAVARGRWPPSGvnlpppeaeAAERRGW 88
Cdd:cd00103    1 KMRLRPWLVEQVDSGTYPGLIWLDEEKTIFRIPWKHAARHDVQEADAKIFKAWAVERGIYQPGG---------TPDPAEW 71

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 564331709  89 KTNFRCALRSTGRFILRQDNSGD-PADPHKVYELSP 123
Cdd:cd00103   72 KARLLCALRSSRGFEEVKDKSKDtPGDPHRVYRLLP 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH