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Conserved domains on  [gi|551635916|ref|XP_005820787|]
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hypothetical protein GUITHDRAFT_90646 [Guillardia theta CCMP2712]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UBX_UBXN8 cd01774
Ubiquitin regulatory domain X (UBX) found in UBX domain protein 8 (UBXN8) and similar proteins; ...
 289-363 2.05e-35

Ubiquitin regulatory domain X (UBX) found in UBX domain protein 8 (UBXN8) and similar proteins; UBXN8, also termed reproduction 8 protein (Rep8), or UBX domain-containing protein 6 (UBXD6), or D8S2298E, belongs to the UBXD family of proteins that contains the ubiquitin regulatory domain X (UBX) with a beta-grasp ubiquitin-like fold, but without the C-terminal double glycine motif. UBX domain is typically located at the carboxyl terminus of proteins, and participates broadly in the regulation of protein degradation. UBXN8 functions as a cofactor of p97 (also known as VCP or Cdc48), which is a homohexameric AAA ATPase (ATPase associated with a variety of activities) involved in a variety of functions ranging from cell-cycle regulation to membrane fusion and protein degradation. UBXN8 is a transmembrane protein that localizes to the endoplasmic reticulum (ER) membrane with its UBX domain facing the cytoplasm. It facilitates efficient ER-associated degradation (ERAD) by tethering p97 to the ER membrane.


:

Pssm-ID: 340472  Cd Length: 76  Bit Score: 123.99  E-value: 2.05e-35
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 551635916 289 SATHIQLRFPDGSRHSRRFLDTETLKVVLDFMFVCGADPEKHTLATAFPRKIL-DEADKSLKDLGLSHHISLNVEK 363
Cdd:cd01774    1 GAVTIALRFPGGRVHRRRFLTTENIQVLLDWMTKLGYHQTLYTLSTTYPRTILsDDADKTLEDLGITKDVALNVEE 76
UAS cd02958
UAS family; UAS is a domain of unknown function. Most members of this family are ...
 24-137 2.78e-35

UAS family; UAS is a domain of unknown function. Most members of this family are uncharacterized proteins with similarity to FAS-associated factor 1 (FAF1) and ETEA because of the presence of a UAS domain N-terminal to a ubiquitin-associated UBX domain. FAF1 is a longer protein, compared to the other members of this family, having additional N-terminal domains, a ubiquitin-associated UBA domain and a nuclear targeting domain. FAF1 is an apoptotic signaling molecule that acts downstream in the Fas signal transduction pathway. It interacts with the cytoplasmic domain of Fas, but not to a Fas mutant that is deficient in signal transduction. ETEA is the protein product of a highly expressed gene in T-cells and eosinophils of atopic dermatitis patients. The presence of the ubiquitin-associated UBX domain in the proteins of this family suggests the possibility of their involvement in ubiquitination. Recently, FAF1 has been shown to interact with valosin-containing protein (VCP), which is involved in the ubiquitin-proteosome pathway. Some members of this family are uncharacterized proteins containing only a UAS domain.


:

Pssm-ID: 239256 [Multi-domain]  Cd Length: 114  Bit Score: 125.03  E-value: 2.78e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551635916  24 MFQGNFDKLREKAEGEEKYCLVNLQKRDIFHSQMLNRDTWSNELVTAVVTSKFIFWQQEFESTAGRQYLSIYPSYTFPVI 103
Cdd:cd02958    1 FFQGSFEDAKQEAKSEKKWLLVYLQSEDEFDSQVLNRDLWSNESVKEFIRENFIFWQCDIDSSEGQRFLQSYKVDKYPHI 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 551635916 104 DIIDPLTGALLERIEEYIAPKDLVERLSRFLDSH 137
Cdd:cd02958   81 AIIDPRTGEVLKVWSGNITPEDLLSQLIEFLEEF 114
 
Name Accession Description Interval E-value
UBX_UBXN8 cd01774
Ubiquitin regulatory domain X (UBX) found in UBX domain protein 8 (UBXN8) and similar proteins; ...
 289-363 2.05e-35

Ubiquitin regulatory domain X (UBX) found in UBX domain protein 8 (UBXN8) and similar proteins; UBXN8, also termed reproduction 8 protein (Rep8), or UBX domain-containing protein 6 (UBXD6), or D8S2298E, belongs to the UBXD family of proteins that contains the ubiquitin regulatory domain X (UBX) with a beta-grasp ubiquitin-like fold, but without the C-terminal double glycine motif. UBX domain is typically located at the carboxyl terminus of proteins, and participates broadly in the regulation of protein degradation. UBXN8 functions as a cofactor of p97 (also known as VCP or Cdc48), which is a homohexameric AAA ATPase (ATPase associated with a variety of activities) involved in a variety of functions ranging from cell-cycle regulation to membrane fusion and protein degradation. UBXN8 is a transmembrane protein that localizes to the endoplasmic reticulum (ER) membrane with its UBX domain facing the cytoplasm. It facilitates efficient ER-associated degradation (ERAD) by tethering p97 to the ER membrane.


Pssm-ID: 340472  Cd Length: 76  Bit Score: 123.99  E-value: 2.05e-35
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 551635916 289 SATHIQLRFPDGSRHSRRFLDTETLKVVLDFMFVCGADPEKHTLATAFPRKIL-DEADKSLKDLGLSHHISLNVEK 363
Cdd:cd01774    1 GAVTIALRFPGGRVHRRRFLTTENIQVLLDWMTKLGYHQTLYTLSTTYPRTILsDDADKTLEDLGITKDVALNVEE 76
UAS cd02958
UAS family; UAS is a domain of unknown function. Most members of this family are ...
 24-137 2.78e-35

UAS family; UAS is a domain of unknown function. Most members of this family are uncharacterized proteins with similarity to FAS-associated factor 1 (FAF1) and ETEA because of the presence of a UAS domain N-terminal to a ubiquitin-associated UBX domain. FAF1 is a longer protein, compared to the other members of this family, having additional N-terminal domains, a ubiquitin-associated UBA domain and a nuclear targeting domain. FAF1 is an apoptotic signaling molecule that acts downstream in the Fas signal transduction pathway. It interacts with the cytoplasmic domain of Fas, but not to a Fas mutant that is deficient in signal transduction. ETEA is the protein product of a highly expressed gene in T-cells and eosinophils of atopic dermatitis patients. The presence of the ubiquitin-associated UBX domain in the proteins of this family suggests the possibility of their involvement in ubiquitination. Recently, FAF1 has been shown to interact with valosin-containing protein (VCP), which is involved in the ubiquitin-proteosome pathway. Some members of this family are uncharacterized proteins containing only a UAS domain.


Pssm-ID: 239256 [Multi-domain]  Cd Length: 114  Bit Score: 125.03  E-value: 2.78e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551635916  24 MFQGNFDKLREKAEGEEKYCLVNLQKRDIFHSQMLNRDTWSNELVTAVVTSKFIFWQQEFESTAGRQYLSIYPSYTFPVI 103
Cdd:cd02958    1 FFQGSFEDAKQEAKSEKKWLLVYLQSEDEFDSQVLNRDLWSNESVKEFIRENFIFWQCDIDSSEGQRFLQSYKVDKYPHI 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 551635916 104 DIIDPLTGALLERIEEYIAPKDLVERLSRFLDSH 137
Cdd:cd02958   81 AIIDPRTGEVLKVWSGNITPEDLLSQLIEFLEEF 114
UAS smart00594
UAS domain;
18-130 1.68e-20

UAS domain;


Pssm-ID: 214737 [Multi-domain]  Cd Length: 122  Bit Score: 85.84  E-value: 1.68e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551635916    18 PPPAKLMFQGNFDKLREKAEGEEKYCLVNLQKRDIFHSQMLNRDTWSNELVTAVVTSKFIFWQQEFESTAGRQYLSIYPS 97
Cdd:smart00594   5 PPYGPLFYQGSLEAAKQEASRQRRLLWLYLHSQDSPDSQVFNRDVLCNEAVKSLIRENFIFWQVDVDTSEGQRVSQFYKL 84

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 551635916    98 YTFPVIDIIDPLTG----ALLERIEEYIAPKDLVERL 130
Cdd:smart00594  85 DSFPYVAIVDPRTGqrviEWVGVVEGEISPEELMTFL 121
UBX pfam00789
UBX domain; This domain is present in ubiquitin-regulatory proteins and is a general ...
 289-353 2.40e-14

UBX domain; This domain is present in ubiquitin-regulatory proteins and is a general Cdc48-interacting module.


Pssm-ID: 395637 [Multi-domain]  Cd Length: 80  Bit Score: 67.70  E-value: 2.40e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 551635916  289 SATHIQLRFPDGSRHSRRFLDTETLKVVLDFMFVCG-ADPEKHTLATAFPRKILDEAD--KSLKDLGL 353
Cdd:pfam00789   3 DVTRLQIRLPDGSRLVRRFNSSDKLQTVYDFVDSNRyDDLEPFSLNTPFPRRPLTDLDysKTLKEAGL 70
Thioredoxin_7 pfam13899
Thioredoxin-like; Thioredoxins are small enzymes that participate in redox reactions, via the ...
 25-108 3.21e-13

Thioredoxin-like; Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond.


Pssm-ID: 433567 [Multi-domain]  Cd Length: 84  Bit Score: 64.69  E-value: 3.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551635916   25 FQGNFDKLREKAEGEEKYCLVNLQKRDIFHSQMLNRDTWSNELVTAVVTSKFIFWQQEFESTAGRQYLSIYPSYTfPVID 104
Cdd:pfam13899   2 WLSDLEEALAAAAERGKPVLVDFGADWCFTCQVLERDFLSHEEVKAALAKNFVLLRLDWTSRDANITRAFDGQGV-PHIA 80


                  ....
gi 551635916  105 IIDP 108
Cdd:pfam13899  81 FLDP 84
UBX smart00166
Domain present in ubiquitin-regulatory proteins; Present in FAF1 and Shp1p.
 290-363 9.98e-08

Domain present in ubiquitin-regulatory proteins; Present in FAF1 and Shp1p.


Pssm-ID: 197552 [Multi-domain]  Cd Length: 77  Bit Score: 48.84  E-value: 9.98e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 551635916   290 ATHIQLRFPDGSRHSRRFLDTETLKVVLDFMFV-CGADPEKHTLATAFPRKILDEAD--KSLKDLGLSHHISLNVEK 363
Cdd:smart00166   1 VCRLQIRLPDGSRLVRRFPSSDTLRTVYEFVSAaLGDGNDPFTLNSPFPRRTFTKDDysKKLLELALLPSSTLVLEP 77
 
Name Accession Description Interval E-value
UBX_UBXN8 cd01774
Ubiquitin regulatory domain X (UBX) found in UBX domain protein 8 (UBXN8) and similar proteins; ...
 289-363 2.05e-35

Ubiquitin regulatory domain X (UBX) found in UBX domain protein 8 (UBXN8) and similar proteins; UBXN8, also termed reproduction 8 protein (Rep8), or UBX domain-containing protein 6 (UBXD6), or D8S2298E, belongs to the UBXD family of proteins that contains the ubiquitin regulatory domain X (UBX) with a beta-grasp ubiquitin-like fold, but without the C-terminal double glycine motif. UBX domain is typically located at the carboxyl terminus of proteins, and participates broadly in the regulation of protein degradation. UBXN8 functions as a cofactor of p97 (also known as VCP or Cdc48), which is a homohexameric AAA ATPase (ATPase associated with a variety of activities) involved in a variety of functions ranging from cell-cycle regulation to membrane fusion and protein degradation. UBXN8 is a transmembrane protein that localizes to the endoplasmic reticulum (ER) membrane with its UBX domain facing the cytoplasm. It facilitates efficient ER-associated degradation (ERAD) by tethering p97 to the ER membrane.


Pssm-ID: 340472  Cd Length: 76  Bit Score: 123.99  E-value: 2.05e-35
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 551635916 289 SATHIQLRFPDGSRHSRRFLDTETLKVVLDFMFVCGADPEKHTLATAFPRKIL-DEADKSLKDLGLSHHISLNVEK 363
Cdd:cd01774    1 GAVTIALRFPGGRVHRRRFLTTENIQVLLDWMTKLGYHQTLYTLSTTYPRTILsDDADKTLEDLGITKDVALNVEE 76
UAS cd02958
UAS family; UAS is a domain of unknown function. Most members of this family are ...
 24-137 2.78e-35

UAS family; UAS is a domain of unknown function. Most members of this family are uncharacterized proteins with similarity to FAS-associated factor 1 (FAF1) and ETEA because of the presence of a UAS domain N-terminal to a ubiquitin-associated UBX domain. FAF1 is a longer protein, compared to the other members of this family, having additional N-terminal domains, a ubiquitin-associated UBA domain and a nuclear targeting domain. FAF1 is an apoptotic signaling molecule that acts downstream in the Fas signal transduction pathway. It interacts with the cytoplasmic domain of Fas, but not to a Fas mutant that is deficient in signal transduction. ETEA is the protein product of a highly expressed gene in T-cells and eosinophils of atopic dermatitis patients. The presence of the ubiquitin-associated UBX domain in the proteins of this family suggests the possibility of their involvement in ubiquitination. Recently, FAF1 has been shown to interact with valosin-containing protein (VCP), which is involved in the ubiquitin-proteosome pathway. Some members of this family are uncharacterized proteins containing only a UAS domain.


Pssm-ID: 239256 [Multi-domain]  Cd Length: 114  Bit Score: 125.03  E-value: 2.78e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551635916  24 MFQGNFDKLREKAEGEEKYCLVNLQKRDIFHSQMLNRDTWSNELVTAVVTSKFIFWQQEFESTAGRQYLSIYPSYTFPVI 103
Cdd:cd02958    1 FFQGSFEDAKQEAKSEKKWLLVYLQSEDEFDSQVLNRDLWSNESVKEFIRENFIFWQCDIDSSEGQRFLQSYKVDKYPHI 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 551635916 104 DIIDPLTGALLERIEEYIAPKDLVERLSRFLDSH 137
Cdd:cd02958   81 AIIDPRTGEVLKVWSGNITPEDLLSQLIEFLEEF 114
UAS smart00594
UAS domain;
18-130 1.68e-20

UAS domain;


Pssm-ID: 214737 [Multi-domain]  Cd Length: 122  Bit Score: 85.84  E-value: 1.68e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551635916    18 PPPAKLMFQGNFDKLREKAEGEEKYCLVNLQKRDIFHSQMLNRDTWSNELVTAVVTSKFIFWQQEFESTAGRQYLSIYPS 97
Cdd:smart00594   5 PPYGPLFYQGSLEAAKQEASRQRRLLWLYLHSQDSPDSQVFNRDVLCNEAVKSLIRENFIFWQVDVDTSEGQRVSQFYKL 84

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 551635916    98 YTFPVIDIIDPLTG----ALLERIEEYIAPKDLVERL 130
Cdd:smart00594  85 DSFPYVAIVDPRTGqrviEWVGVVEGEISPEELMTFL 121
UBX cd01767
Ubiquitin regulatory domain X (UBX) structurally similar to a beta-grasp ubiquitin-like fold; ...
 292-362 3.74e-15

Ubiquitin regulatory domain X (UBX) structurally similar to a beta-grasp ubiquitin-like fold; The UBXD family of proteins contains the ubiquitin regulatory domain X (UBX) with a beta-grasp ubiquitin-like fold, but without the C-terminal double glycine motif. UBX domain is typically located at the carboxyl terminus of proteins, and participates broadly in the regulation of protein degradation. Members in this family function as cofactors of p97 (also known as VCP or Cdc48), which is a homohexameric AAA ATPase (ATPase associated with a variety of activities) involved in a variety of functions ranging from cell-cycle regulation to membrane fusion and protein degradation. Based on domain composition, UBXD proteins can be divided into two main groups, with and without ubiquitin-associated (UBA) domain.


Pssm-ID: 340466 [Multi-domain]  Cd Length: 74  Bit Score: 69.60  E-value: 3.74e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 551635916 292 HIQLRFPDGSRHSRRFLDTETLKVVLDFMF-VCGADPEKHTLATAFPRKIL--DEADKSLKDLGLSHHISLNVE 362
Cdd:cd01767    1 RIQIRLPDGSRIQRRFSKSDTLQDLYDFVEsNLGDSPSSFSLVTSFPRRVLtdEDSDKTLEELGLTPNAVLFVE 74
UBX_UBXN3B cd16120
Ubiquitin regulatory domain X (UBX) found in FAS associated factor 2 (FAF2, also known as ...
 291-361 1.72e-14

Ubiquitin regulatory domain X (UBX) found in FAS associated factor 2 (FAF2, also known as UBXN3B) and similar proteins; UBX domain-containing protein 3B (UBXN3B), also termed protein ETEA, or FAF2, or UBX domain-containing protein 8 (UBXD8), belongs to the UBXD family of proteins that contains the ubiquitin regulatory domain X (UBX) with a beta-grasp ubiquitin-like fold, but without the C-terminal double glycine motif. UBX domain is typically located at the carboxyl terminus of proteins, and participates broadly in the regulation of protein degradation. FAF2 functions as a cofactor of p97 (also known as VCP or Cdc48), which is a homohexameric AAA ATPase (ATPase associated with a variety of activities) involved in a variety of functions ranging from cell-cycle regulation to membrane fusion and protein degradation. The p97-UBXD8 complex destabilizes mRNA by promoting release of ubiquitinated the RNA-binding protein HuR from messenger ribonucleoprotein (mRNP). Moreover, FAF2 is the translation product of a highly expressed gene in the T-cells and eosinophils of atopic dermatitis patients compared with those of normal individuals. A yeast two-hybrid assay showed that FAF2 can interact with Fas.


Pssm-ID: 340537  Cd Length: 80  Bit Score: 68.07  E-value: 1.72e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 551635916 291 THIQLRFPDGSRHSRRFLDTETLKVVLDFMFVCGADPEKHTLATAFPRKIL-------DEADKSLKDLGLSHHISLNV 361
Cdd:cd16120    1 VKILFKLPNGTRLERRFLKSDSLKVLYDFVFSHEDSPDKFQLVTNFPRRVLpcqpteeQPNPPTLEEAGLGKSEVLFV 78
UBX pfam00789
UBX domain; This domain is present in ubiquitin-regulatory proteins and is a general ...
 289-353 2.40e-14

UBX domain; This domain is present in ubiquitin-regulatory proteins and is a general Cdc48-interacting module.


Pssm-ID: 395637 [Multi-domain]  Cd Length: 80  Bit Score: 67.70  E-value: 2.40e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 551635916  289 SATHIQLRFPDGSRHSRRFLDTETLKVVLDFMFVCG-ADPEKHTLATAFPRKILDEAD--KSLKDLGL 353
Cdd:pfam00789   3 DVTRLQIRLPDGSRLVRRFNSSDKLQTVYDFVDSNRyDDLEPFSLNTPFPRRPLTDLDysKTLKEAGL 70
Thioredoxin_7 pfam13899
Thioredoxin-like; Thioredoxins are small enzymes that participate in redox reactions, via the ...
 25-108 3.21e-13

Thioredoxin-like; Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond.


Pssm-ID: 433567 [Multi-domain]  Cd Length: 84  Bit Score: 64.69  E-value: 3.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551635916   25 FQGNFDKLREKAEGEEKYCLVNLQKRDIFHSQMLNRDTWSNELVTAVVTSKFIFWQQEFESTAGRQYLSIYPSYTfPVID 104
Cdd:pfam13899   2 WLSDLEEALAAAAERGKPVLVDFGADWCFTCQVLERDFLSHEEVKAALAKNFVLLRLDWTSRDANITRAFDGQGV-PHIA 80


                  ....
gi 551635916  105 IIDP 108
Cdd:pfam13899  81 FLDP 84
UBX_UBXN3A cd01771
Ubiquitin regulatory domain X (UBX) found in FAS associated factor 1 (FAF1, also known as ...
 291-364 6.78e-13

Ubiquitin regulatory domain X (UBX) found in FAS associated factor 1 (FAF1, also known as UBXN3A) and similar proteins; UBX domain-containing protein 3A (UBXN3A),also termed UBX domain-containing protein 12 (UBXD12), or FAF1, belongs to the UBXD family of proteins that contains the ubiquitin regulatory domain X (UBX) with a beta-grasp ubiquitin-like fold, but without the C-terminal double glycine motif. UBX domain is typically located at the carboxyl terminus of proteins, and participates broadly in the regulation of protein degradation. In addition, FAF1 contains two tandem ubiquitin-like (Ubl) domains, which shows high structural similarity with UBX domain. FAF1 functions as a cofactor of p97 (also known as VCP or Cdc48), which is a homohexameric AAA ATPase (ATPase associated with a variety of activities) involved in a variety of functions ranging from cell-cycle regulation to membrane fusion and protein degradation. The FAF1-p97 complex inhibits the proteasomal protein degradation in which p97 acts as a co-chaperone. Moreover, FAF1 is an apoptotic signaling molecule that acts downstream in the Fas signal transduction pathway. It interacts with the cytoplasmic domain of Fas, but not to a Fas mutant that is deficient in signal transduction. FAF1 is widely expressed in adult and embryonic tissues, and in tumor cell lines, and is localized not only in the cytoplasm where it interacts with Fas, but also in the nucleus. FAF1 contains phosphorylation sites for protein kinase CK2 within the nuclear targeting domain. Phosphorylation influences nuclear localization of FAF1 but does not affect its potentiation of Fas-induced apoptosis. Other functions have also been attributed to FAF1. It inhibits nuclear factor-kappaB (NF-kappaB) by interfering with the nuclear translocation of the p65 subunit. Although the precise role of FAF1 in the ubiquitination pathway remains unclear, FAF1 interacts with valosin-containing protein (VCP), which is involved in the ubiquitin-proteosome pathway. This family corresponds to UBX domain.


Pssm-ID: 340469  Cd Length: 80  Bit Score: 63.40  E-value: 6.78e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 551635916 291 THIQLRFPDGSRHSRRFLDTETLKVVLDFMFVCGADPEKHTLATAFPRKILDEAD--KSLKDLGLSHHISLNVEKK 364
Cdd:cd01771    5 SKLRFRLPGGEFLTRRFLASEPLQVLLNFVASKGYPPDEYKLLTTFPRRDLTQLDpsKTLEELKLFPQETLFLEER 80
UBX_UBXN1 cd01772
Ubiquitin regulatory domain X (UBX) found in UBX domain protein 1 (UBXN1) and similar proteins; ...
 285-353 2.52e-08

Ubiquitin regulatory domain X (UBX) found in UBX domain protein 1 (UBXN1) and similar proteins; UBXN1, also termed SAPK substrate protein 1 (SAKS1), UBA/UBX 33.3 kDa protein (Y33K), or UBXD10, is a widely expressed protein containing an N-terminal ubiquitin-associated (UBA) domain, a coiled-coil region, and a C-terminal ubiquitin-like (Ubl or UBX) domain that has a beta-grasp ubiquitin-like fold without the C-terminal double glycine motif. UBXN1 has been identified as a substrate for stress-activated protein kinases (SAPKs). It binds polyubiquitin and valosin-containing protein (VCP), suggesting a role as an adaptor that directs VCP to polyubiquitinated proteins facilitating its destruction by the proteasome. In addition, UBXN1 specifically binds to Homer2b. It may also interact with ubiquitin (Ub) and be involved in the Ub-proteasome proteolytic pathways. UBXN1 can also associate with autoubiquitinated BRCA1 tumor suppressor and inhibit its enzymatic function through its UBA domains.


Pssm-ID: 340470 [Multi-domain]  Cd Length: 81  Bit Score: 50.77  E-value: 2.52e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 551635916 285 KEDRSATHIQLRFPDGSRHSRRFLDTETLKVVLDFMFVCGAD-PEKHTLATAFPRKILDEAD--KSLKDLGL 353
Cdd:cd01772    1 KKEYDECRLQVRLTNGSTLTQTFGAKEQLAAVRLYVELNRTDgDGPFSLMTTFPRKVFTEEDmeKPLKELGL 72
UBX_UBXN2 cd01770
Ubiquitin regulatory domain X (UBX) found in UBX domain-containing proteins UBXN2A, UBXN2B, ...
 293-353 7.05e-08

Ubiquitin regulatory domain X (UBX) found in UBX domain-containing proteins UBXN2A, UBXN2B, NSFL1C/UBXN2C, and similar proteins; This family includes UBX domain-containing proteins UBXN2A, UBXN2B, and NSFL1C/UBXN2C, which contain a SEP (Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47) domain, and a ubiquitin regulatory domain X (UBX) with a beta-grasp ubiquitin-like fold at the C-terminus. UBX domain participates broadly in the regulation of protein degradation. UBXN2A, UBXN2B, and UBXN2C function as the adaptor proteins of p97 (also known as VCP or Cdc48), which is a homohexameric AAA ATPase (ATPase associated with a variety of activities) involved in a variety of functions ranging from cell-cycle regulation to membrane fusion and protein degradation.


Pssm-ID: 340468  Cd Length: 71  Bit Score: 49.10  E-value: 7.05e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 551635916 293 IQLRFPDGSRHSRRFLDTETLKVVldFMFVCGADPE---KHTLATAFPRKILDEADKSLKDLGL 353
Cdd:cd01770    2 IQIRLADGSRLVARFNLTHTVGDI--RQFIDSARPGysrPFVLMTGFPPKELTDESQTLEEAGL 63
UBX_UBXN4 cd16117
Ubiquitin regulatory domain X (UBX) found in UBX domain protein 4 (UBXN4) and similar proteins; ...
 293-354 9.80e-08

Ubiquitin regulatory domain X (UBX) found in UBX domain protein 4 (UBXN4) and similar proteins; UBXN4, also termed ERAD (endoplasmic-reticulum-associated protein degradation) substrate erasing protein (erasin), or UBX domain-containing protein 2 (UBXD2), or UBXDC1, belongs to the UBXD family of proteins that contains the ubiquitin regulatory domain X (UBX) with a beta-grasp ubiquitin-like fold, but without the C-terminal double glycine motif. UBX domain is typically located at the carboxyl terminus of proteins, and participates broadly in the regulation of protein degradation. UBXN4 is an endoplasmic reticulum (ER) localized protein that interacts with p97 (also known as VCP or Cdc48) via its UBX domain. Erasin exists in a complex with other p97/VCP-associated factors involved in endoplasmic-reticulum-associated protein degradation (ERAD). p97 is a homohexameric AAA ATPase (ATPase associated with a variety of activities) involved in a variety of functions ranging from cell-cycle regulation to membrane fusion and protein degradation. The overexpression of UBXN4 increases degradation of a classical ERAD substrate and UBXN4 levels are increased in ER stressed cells. Anti-UBXN4 staining is increased in neuropathological lesions in brains of patients with Alzheimer's disease.


Pssm-ID: 340534 [Multi-domain]  Cd Length: 77  Bit Score: 48.87  E-value: 9.80e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 551635916 293 IQLRFPDGSRHSRRFLDTETLKVVLDfmFVC---GADPEKHTLATAFPRKILDEAD--KSLKDLGLS 354
Cdd:cd16117    4 IQFRLPDGSSFTNQFPSDAPLEEARQ--FVAqtvGPAYGPFSLATTFPRREFTDDDyqKTLLELELA 68
UBX smart00166
Domain present in ubiquitin-regulatory proteins; Present in FAF1 and Shp1p.
 290-363 9.98e-08

Domain present in ubiquitin-regulatory proteins; Present in FAF1 and Shp1p.


Pssm-ID: 197552 [Multi-domain]  Cd Length: 77  Bit Score: 48.84  E-value: 9.98e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 551635916   290 ATHIQLRFPDGSRHSRRFLDTETLKVVLDFMFV-CGADPEKHTLATAFPRKILDEAD--KSLKDLGLSHHISLNVEK 363
Cdd:smart00166   1 VCRLQIRLPDGSRLVRRFPSSDTLRTVYEFVSAaLGDGNDPFTLNSPFPRRTFTKDDysKKLLELALLPSSTLVLEP 77
UBX_UBXN7 cd01773
Ubiquitin regulatory domain X (UBX) found in UBX domain protein 7 (UBXN7) and similar proteins; ...
 293-363 2.05e-05

Ubiquitin regulatory domain X (UBX) found in UBX domain protein 7 (UBXN7) and similar proteins; UBXN7, also termed UBX domain-containing protein 7 (UBXD7), belongs to the UBXD family of proteins that contains the ubiquitin regulatory domain X (UBX) with a beta-grasp ubiquitin-like fold, but without the C-terminal double glycine motif. UBX domain is typically located at the carboxyl terminus of proteins, and participates broadly in the regulation of protein degradation. UBXN7 functions as a ubiquitin-binding adaptor that mediates the interaction between the AAA+ ATPase p97 (also known as VCP or Cdc48) and the transcription factor HIF1-alpha. It binds only to the active, NEDD8- or Rub1-modified form of cullins. In addition to having a UBX domain, UBXD7 contains a ubiquitin-associated (UBA), ubiquitin-associating (UAS), and ubiquitin-interacting motif (UIM) domains. Either UBA or UIM could serve as a docking site for neddylated-cullins. UBA domain is required for binding ubiquitylated-protein substrates, while the UIM motif is responsible for the binding to cullin RING ligases (CRLs), and the UBX domain is essential for p97 binding.


Pssm-ID: 340471  Cd Length: 76  Bit Score: 42.23  E-value: 2.05e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 551635916 293 IQLRFPDGSRHSRRFLDTETLKVVLDFMFVCGADPEKHTLATAFPRKILD--EADKSLKDLGLSHHISLNVEK 363
Cdd:cd01773    4 LMLRFPDGKREQLSLPASAKLKALVKYVSSKGYPNERYELVTNFPRRKLShlDYDITLKEAGLCPQETIFVQE 76
UBX_UBXN10 cd17076
Ubiquitin regulatory domain X (UBX) found in UBX domain protein 10 (UBXN10) and similar ...
 295-362 1.47e-04

Ubiquitin regulatory domain X (UBX) found in UBX domain protein 10 (UBXN10) and similar proteins; UBXN10, also termed UBX domain-containing protein 3 (UBXD3), belongs to the UBXD family of proteins that contains the ubiquitin regulatory domain X (UBX) with a beta-grasp ubiquitin-like fold, but without the C-terminal double glycine motif. UBX domain is typically located at the carboxyl terminus of proteins, and participates broadly in the regulation of protein degradation. UBXN10 functions as a cofactor of p97 (also known as VCP or Cdc48), which is a homohexameric AAA ATPase (ATPase associated with a variety of activities) involved in a variety of functions ranging from cell-cycle regulation to membrane fusion and protein degradation. UBXN10 localizes to cilia in a p97-dependent manner, and both p97 and UBXN10 are required for ciliogenesis. Additionally, UBXN10 interacts with the intraflagellar transport B (IFT-B) and regulates anterograde transport into cilia.


Pssm-ID: 340596  Cd Length: 76  Bit Score: 39.92  E-value: 1.47e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551635916 295 LRFPDGSRHSRRFLDTETLKVVLDFM-FVCGADPEKHTLAT-AFPRKILDEADKSLKDLGLSHHISLNVE 362
Cdd:cd17076    7 IRLPDGQRFQRFFRPSDTLQDVLAFAeSQSGLDLSNCIIETnEVPRRVFSDLSKTIAECGIQDKTVLYIE 76
UAS_ETEA cd02991
UAS family, ETEA subfamily; composed of proteins similar to human ETEA protein, the ...
 25-135 3.06e-04

UAS family, ETEA subfamily; composed of proteins similar to human ETEA protein, the translation product of a highly expressed gene in the T-cells and eosinophils of atopic dermatitis patients compared with those of normal individuals. ETEA shows homology to Fas-associated factor 1 (FAF1); both containing UAS and UBX (ubiquitin-associated) domains. Compared to FAF1, however, ETEA lacks the ubiquitin-associated UBA domain and a nuclear targeting domain. The function of ETEA is still unknown. A yeast two-hybrid assay showed that it can interact with Fas. Because of its homology to FAF1, it is postulated that ETEA could be involved in modulating Fas-mediated apoptosis of T-cells and eosinophils of atopic dermatitis patients, making them more resistant to apoptosis.


Pssm-ID: 239289  Cd Length: 116  Bit Score: 40.16  E-value: 3.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551635916  25 FQGNFDKLREKAEGEEKYCLVNLQKRDIFHSQMLNRDTWSNELVTAVVTSKFIFWQQEFESTAGRQYLSIYPSYTFPVID 104
Cdd:cd02991    2 YQGTYSQALNDAKQELRFLLVYLHGDDHQDTDEFCRNTLCAPEVIEYINTRMLFWACSVAKPEGYRVSQALRERTYPFLA 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 551635916 105 II----DPLTgaLLERIEEYIAPKDLVERLSRFLD 135
Cdd:cd02991   82 MImlkdNRMT--IVGRLEGLIQPEDLINRLTFIMD 114
UBX2_UBXN9 cd16118
Ubiquitin regulatory domain X (UBX) 2 found in UBX domain protein 9 (UBXN9, UBXD9, or ASPSCR1) ...
 293-353 2.48e-03

Ubiquitin regulatory domain X (UBX) 2 found in UBX domain protein 9 (UBXN9, UBXD9, or ASPSCR1) and similar proteins; UBXN9, also termed tether containing UBX domain for GLUT4 (TUG), or alveolar soft part sarcoma chromosomal region candidate gene 1 protein (ASPSCR1), or alveolar soft part sarcoma locus (ASPL), or renal papillary cell carcinoma protein 17 (RCC17), belongs to the UBXD family of proteins that contains two ubiquitin regulatory domains X (UBX) with a beta-grasp ubiquitin-like fold, but without the C-terminal double glycine motif. UBX domain is typically located at the carboxyl terminus of proteins, and participates broadly in the regulation of protein degradation. In addition, UBXN9 contains an N-terminal ubiquitin-like (Ubl) domain. UBXN9 functions as a cofactor of p97 (also known as VCP or Cdc48), which is a homohexameric AAA ATPase (ATPase associated with a variety of activities) involved in a variety of functions ranging from cell-cycle regulation to membrane fusion and protein degradation. However, high-affinity interacting protein ASPL efficiently promotes p97 hexamer disassembly, resulting in the formation of stable p97:ASPL heterotetramers; the extended UBX domain (eUBX) in ASPL is critical for p97 hexamer disassembly and facilitates the assembly of p97:ASPL heterotetramers.UBXN9 is involved in insulin-stimulated redistribution of the glucose transporter GLUT4, assembly of the Golgi apparatus. In addition to GLUT4, UBXN9 also controls vesicle translocation by interacting with insulin-regulated aminopeptidase (IRAP), a transmembrane aminopeptidase. UBXN9 and its budding yeast ortholog, Ubx4p, are multifunctional proteins that share some, but not all functions. Yeast Ubx4p is important for endoplasmic reticulum-associated protein degradation (ERAD) but UBXN9 appears not to share this function.


Pssm-ID: 340535  Cd Length: 74  Bit Score: 36.39  E-value: 2.48e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 551635916 293 IQLRFPDGSRHSRRFLDTETLKVVLDFMFVCGADPE-KHTLATAFPRKILDEADKSLKDLGL 353
Cdd:cd16118    3 IRVQFPDRLVLQAFFRPLETVRALYDFVKSHLADPDlPFYLYTTPPKRVLKDKNKTLYQAGL 64
UBX_UBXN2C cd17162
Ubiquitin regulatory domain X (UBX) found in NSFL1 cofactor (also known as UBX ...
 286-353 3.94e-03

Ubiquitin regulatory domain X (UBX) found in NSFL1 cofactor (also known as UBX domain-containing protein 2C (UBXN2C) and similar proteins; UBXN2C, also termed NSFL1C, or NSFL1 cofactor p47, or p97 cofactor p47, UBX1, or UBXD10, belongs to the UBXD family of proteins that contains the ubiquitin regulatory domain X (UBX) with a beta-grasp ubiquitin-like fold, but without the C-terminal double glycine motif. UBX domain is typically located at the carboxyl terminus of proteins, and participates broadly in the regulation of protein degradation. UBXN2C is a major adaptor of p97 (also known as VCP or Cdc48), which is a homohexameric AAA ATPase (ATPase associated with a variety of activities) involved in a variety of functions ranging from cell-cycle regulation to membrane fusion and protein degradation. The main role of the UBXN2C/p97 complex is in regulation of membrane fusion events. It plays an essential role in the reassembly of Golgi stacks at the end of mitosis. UBXN2C also functions as an essential factor for Golgi membrane fusion, which associates with the nuclear factor-kappaB essential modulator (NEMO) subunit of the IkappaB kinase (IKK) complex upon tumor necrosis factor (TNF)-alpha or interleukin (IL)-1 stimulation, induces the lysosome-dependent degradation of polyubiquitinated NEMO without p97, and thus inhibits IKK activation. Moreover, UBXN2C regulates a membrane fusion process, which is required by the maintenance of the endoplasmic reticulum (ER) network, through phosphorylation by Cdc2 kinase.


Pssm-ID: 340682  Cd Length: 82  Bit Score: 36.06  E-value: 3.94e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 551635916 286 EDRSATHIQLRFPDGSRHSRRFLDTETLKVVLdfMFVCGADP----EKHTLATAFPRKILDEADKSLKDLGL 353
Cdd:cd17162    3 DSEPVTNIQIRLADGGRLVQKFNHSHRIRDIR--LFIVDARPamaaTSFVLMTTFPNKELTDENQTLKEANL 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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