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Conserved domains on  [gi|530370261|ref|XP_005246568|]
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homeobox protein Hox-D3 isoform X1 [Homo sapiens]

Protein Classification

homeobox domain-containing protein( domain architecture ID 11079064)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes; homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes; similar to transcription factor LBX, NK1 transcription factor-related protein, and thyroid transcription factor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
195-251 1.43e-28

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 106.43  E-value: 1.43e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 530370261  195 KRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKK 251
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
DUF4074 pfam13293
Domain of unknown function (DUF4074); This family is found at the C-terminal of Homeobox ...
 369-430 4.25e-26

Domain of unknown function (DUF4074); This family is found at the C-terminal of Homeobox proteins in Metazoa.


:

Pssm-ID: 463833  Cd Length: 63  Bit Score: 99.93  E-value: 4.25e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530370261  369 ASGP-VFNLGHLSHPSSASVDYSCAAQIPGNHHHGPCDPHPTYTDLSAHHSSQGRLPEAPKLT 430
Cdd:pfam13293   1 GSGPsVFGLNHLPHPSSASMDYSGAAQMPPSQHHGPCDPHPTYTDLSSHHPSQGRIQEAPKLT 63
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
195-251 1.43e-28

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 106.43  E-value: 1.43e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 530370261  195 KRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKK 251
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
DUF4074 pfam13293
Domain of unknown function (DUF4074); This family is found at the C-terminal of Homeobox ...
 369-430 4.25e-26

Domain of unknown function (DUF4074); This family is found at the C-terminal of Homeobox proteins in Metazoa.


Pssm-ID: 463833  Cd Length: 63  Bit Score: 99.93  E-value: 4.25e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530370261  369 ASGP-VFNLGHLSHPSSASVDYSCAAQIPGNHHHGPCDPHPTYTDLSAHHSSQGRLPEAPKLT 430
Cdd:pfam13293   1 GSGPsVFGLNHLPHPSSASMDYSGAAQMPPSQHHGPCDPHPTYTDLSSHHPSQGRIQEAPKLT 63
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 194-250 8.24e-26

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 98.86  E-value: 8.24e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 530370261   194 SKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYK 250
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 195-253 7.79e-25

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 96.54  E-value: 7.79e-25
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530370261 195 KRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQ 253
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
185-269 4.51e-14

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 69.39  E-value: 4.51e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370261 185 EDKSPPGPaSKRVRTayTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKAKGILHSPAS 264
Cdd:COG5576   45 QDGSSPPK-SKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKVEQRPGEE 121


                 ....*
gi 530370261 265 QSPER 269
Cdd:COG5576  122 EADLA 126
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
195-251 1.43e-28

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 106.43  E-value: 1.43e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 530370261  195 KRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKK 251
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
DUF4074 pfam13293
Domain of unknown function (DUF4074); This family is found at the C-terminal of Homeobox ...
 369-430 4.25e-26

Domain of unknown function (DUF4074); This family is found at the C-terminal of Homeobox proteins in Metazoa.


Pssm-ID: 463833  Cd Length: 63  Bit Score: 99.93  E-value: 4.25e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530370261  369 ASGP-VFNLGHLSHPSSASVDYSCAAQIPGNHHHGPCDPHPTYTDLSAHHSSQGRLPEAPKLT 430
Cdd:pfam13293   1 GSGPsVFGLNHLPHPSSASMDYSGAAQMPPSQHHGPCDPHPTYTDLSSHHPSQGRIQEAPKLT 63
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 194-250 8.24e-26

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 98.86  E-value: 8.24e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 530370261   194 SKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYK 250
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 195-253 7.79e-25

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 96.54  E-value: 7.79e-25
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530370261 195 KRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQ 253
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
185-269 4.51e-14

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 69.39  E-value: 4.51e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370261 185 EDKSPPGPaSKRVRTayTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKAKGILHSPAS 264
Cdd:COG5576   45 QDGSSPPK-SKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKVEQRPGEE 121


                 ....*
gi 530370261 265 QSPER 269
Cdd:COG5576  122 EADLA 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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