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Conserved domains on  [gi|528481356|ref|XP_005168754|]
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origin recognition complex subunit 4 isoform X1 [Danio rerio]

Protein Classification

origin recognition complex subunit 4( domain architecture ID 13386334)

origin recognition complex subunit 4 is a component of the origin recognition complex (ORC), an ATP-dependent DNA-binding complex that binds origins of replication

CATH:  3.40.50.300
Gene Symbol:  ORC4
Gene Ontology:  GO:0006270|GO:0006260|GO:0005524|GO:0000808|GO:0003688
PubMed:  20130679|18208389|18466635|16828312|15037233|17241905
SCOP:  4000172|4000283

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ORC4_C pfam14629
Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of ...
 226-413 7.75e-61

Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of origin recognition complex subunit 4.


:

Pssm-ID: 464223  Cd Length: 212  Bit Score: 196.79  E-value: 7.75e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356  226 DVVRLQLSLPQDF----PDHRFSSQWNQSVTKLCEDKSVLEVLKRSFNSSKDFRSLYSLLFMAVSRVSVSHSTLCEADFL 301
Cdd:pfam14629   1 EICKSLLSLPSDEssseGDKKFLEQWNASIEELLEDSTVQDILKRLYYTTKSVRSLLNSLILPVSKLSPDSPLLTAESLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356  302 ESGRLISADSKANVLHGLSILELCLIIAMKHLNDTYDGEPFNFQMVHNEFKKFIQRK-------------SHSIHKFEKP 368
Cdd:pfam14629  81 SALSSQSPDSKLSLLRSLSVLELCLLIAAARLSEIYDTDTFNFEMVYDEYKKLAKRSkvspssatsqssaASGIRVWGRP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 528481356  369 VVMKAFEHLLQLELVRPVD-------SGVCKVQREYQLMRLMLEHGQVMEAL 413
Cdd:pfam14629 161 VALKAWEHLLSLELLVPVGavstggaSSGSGGGKEFRMVRLDITLEEIREAV 212
CDC6 super family cl34277
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
31-224 6.04e-15

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG1474:

Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 76.04  E-value: 6.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356  31 LPDQPIGLDSQYKHLLELLRrTAVHGES-NSVLIVGPRGSGKTMLLGCVLRELMS-LKEVQKNVLLVELNGLLQTDDKIA 108
Cdd:COG1474   24 VPDRLPHREEEIEELASALR-PALRGERpSNVLIYGPTGTGKTAVAKYVLEELEEeAEERGVDVRVVYVNCRQASTRYRV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356 109 LKEITRQLHLENVVGDKvfG-SFAENLAFLLEALKKGDksssRPVLFLLDEFDLFAHHKNQTLLYNLLDVSQS-AQTPVA 186
Cdd:COG1474  103 LSRILEELGSGEDIPST--GlSTDELFDRLYEALDERD----GVLVVVLDEIDYLVDDEGDDLLYQLLRANEElEGARVG 176

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 528481356 187 VVGLTCRLDVLELLEKRVKSRFSHRQIHlfsslsFSQY 224
Cdd:COG1474  177 VIGISNDLEFLENLDPRVKSSLGEEEIV------FPPY 208
 
Name Accession Description Interval E-value
ORC4_C pfam14629
Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of ...
 226-413 7.75e-61

Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of origin recognition complex subunit 4.


Pssm-ID: 464223  Cd Length: 212  Bit Score: 196.79  E-value: 7.75e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356  226 DVVRLQLSLPQDF----PDHRFSSQWNQSVTKLCEDKSVLEVLKRSFNSSKDFRSLYSLLFMAVSRVSVSHSTLCEADFL 301
Cdd:pfam14629   1 EICKSLLSLPSDEssseGDKKFLEQWNASIEELLEDSTVQDILKRLYYTTKSVRSLLNSLILPVSKLSPDSPLLTAESLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356  302 ESGRLISADSKANVLHGLSILELCLIIAMKHLNDTYDGEPFNFQMVHNEFKKFIQRK-------------SHSIHKFEKP 368
Cdd:pfam14629  81 SALSSQSPDSKLSLLRSLSVLELCLLIAAARLSEIYDTDTFNFEMVYDEYKKLAKRSkvspssatsqssaASGIRVWGRP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 528481356  369 VVMKAFEHLLQLELVRPVD-------SGVCKVQREYQLMRLMLEHGQVMEAL 413
Cdd:pfam14629 161 VALKAWEHLLSLELLVPVGavstggaSSGSGGGKEFRMVRLDITLEEIREAV 212
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
31-224 6.04e-15

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 76.04  E-value: 6.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356  31 LPDQPIGLDSQYKHLLELLRrTAVHGES-NSVLIVGPRGSGKTMLLGCVLRELMS-LKEVQKNVLLVELNGLLQTDDKIA 108
Cdd:COG1474   24 VPDRLPHREEEIEELASALR-PALRGERpSNVLIYGPTGTGKTAVAKYVLEELEEeAEERGVDVRVVYVNCRQASTRYRV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356 109 LKEITRQLHLENVVGDKvfG-SFAENLAFLLEALKKGDksssRPVLFLLDEFDLFAHHKNQTLLYNLLDVSQS-AQTPVA 186
Cdd:COG1474  103 LSRILEELGSGEDIPST--GlSTDELFDRLYEALDERD----GVLVVVLDEIDYLVDDEGDDLLYQLLRANEElEGARVG 176

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 528481356 187 VVGLTCRLDVLELLEKRVKSRFSHRQIHlfsslsFSQY 224
Cdd:COG1474  177 VIGISNDLEFLENLDPRVKSSLGEEEIV------FPPY 208
TIGR02928 TIGR02928
orc1/cdc6 family replication initiation protein; Members of this protein family are found ...
 23-224 1.67e-11

orc1/cdc6 family replication initiation protein; Members of this protein family are found exclusively in the archaea. This set of DNA binding proteins shows homology to the origin recognition complex subunit 1/cell division control protein 6 family in eukaryotes. Several members may be found in genome and interact with each other. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274354 [Multi-domain]  Cd Length: 365  Bit Score: 65.35  E-value: 1.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356   23 RERLCHQKLPDQPIGLDSQYKHLLELLRrTAVHGE-SNSVLIVGPRGSGKTMLLGCVLRELMSL-KEVQKNVLLVELNgl 100
Cdd:TIGR02928   5 RDLLEPDYVPDRIVHRDEQIEELAKALR-PILRGSrPSNVFIYGKTGTGKTAVTKYVMKELEEAaEDRDVRVVTVYVN-- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356  101 LQTDDKI--ALKEITRQLhleNVVGDKV--FG-SFAENLAFLLEALKKGDKSssrpVLFLLDEFDLFAHHKNqTLLYNLL 175
Cdd:TIGR02928  82 CQILDTLyqVLVELANQL---RGSGEEVptTGlSTSEVFRRLYKELNERGDS----LIIVLDEIDYLVGDDD-DLLYQLS 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 528481356  176 ------DVSQSaqtPVAVVGLTCRLDVLELLEKRVKSRFSHRQIHlfsslsFSQY 224
Cdd:TIGR02928 154 rarsngDLDNA---KVGVIGISNDLKFRENLDPRVKSSLCEEEII------FPPY 199
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 44-211 7.24e-09

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 54.46  E-value: 7.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356  44 HLLELLRRTAVHGESNSVLIVGPRGSGKTMLLGCVLRElmsLKEVQKNVLLVELNGLLQTDdkialkeitrqlhlenvVG 123
Cdd:cd00009    5 EAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANE---LFRPGAPFLYLNASDLLEGL-----------------VV 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356 124 DKVFGSFAENLAFLLEALKKGDksssrpVLFlLDEFDLFAHHKNQTLLYNLLDVSQSAQTP--VAVVGLTCRLDVLELLE 201
Cdd:cd00009   65 AELFGHFLVRLLFELAEKAKPG------VLF-IDEIDSLSRGAQNALLRVLETLNDLRIDRenVRVIGATNRPLLGDLDR 137

                        170
                 ....*....|
gi 528481356 202 KRvKSRFSHR 211
Cdd:cd00009  138 AL-YDRLDIR 146
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 34-188 1.36e-08

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 54.05  E-value: 1.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356   34 QPIGLDSQYKHLLELLRRTAvHGESNSVLIVGPRGSGKTMLLGCVLRELMSLKEVQKNVLLVELNGLLQTDDKIALKEIT 113
Cdd:pfam13191   1 RLVGREEELEQLLDALDRVR-SGRPPSVLLTGEAGTGKTTLLRELLRALERDGGYFLRGKCDENLPYSPLLEALTREGLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356  114 RQLHLENVV----------------GDKVFGSFAENLAFLLEALKKGDKSSSRPVLFLLDEFDLFAHHkNQTLLYNLLDV 177
Cdd:pfam13191  80 RQLLDELESslleawraallealapVPELPGDLAERLLDLLLRLLDLLARGERPLVLVLDDLQWADEA-SLQLLAALLRL 158

                         170
                  ....*....|.
gi 528481356  178 SQsaQTPVAVV 188
Cdd:pfam13191 159 LE--SLPLLVV 167
cdc6 PRK00411
ORC1-type DNA replication protein;
39-229 1.74e-08

ORC1-type DNA replication protein;


Pssm-ID: 234751 [Multi-domain]  Cd Length: 394  Bit Score: 56.01  E-value: 1.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356  39 DSQYKHLLELLRrTAVHGESNS-VLIVGPRGSGKTMLLGCVLRELmslKEVQKNVLLVELNGllQTDD---KIaLKEITR 114
Cdd:PRK00411  36 EEQIEELAFALR-PALRGSRPLnVLIYGPPGTGKTTTVKKVFEEL---EEIAVKVVYVYINC--QIDRtryAI-FSEIAR 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356 115 QLHLENV--VG---DKVFGSFAEnlaflleALKKGDKsssrpVLFL-LDEFD-LFAHHKNQTLlYNLL---DVSQSAQtp 184
Cdd:PRK00411 109 QLFGHPPpsSGlsfDELFDKIAE-------YLDERDR-----VLIVaLDDINyLFEKEGNDVL-YSLLrahEEYPGAR-- 173

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 528481356 185 VAVVGLTCRLDVLELLEKRVKSRFSHRQIHlFSSLSFSQYVDVVR 229
Cdd:PRK00411 174 IGVIGISSDLTFLYILDPRVKSVFRPEEIY-FPPYTADEIFDILK 217
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 59-215 2.46e-08

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 52.76  E-value: 2.46e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356    59 NSVLIVGPRGSGKTMLLGCVLRElmsLKEVQKNVLLVELNGLLQTDDkialkeitRQLHLENVVGDKVFGSFAENLAFLL 138
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARE---LGPPGGGVIYIDGEDILEEVL--------DQLLLIIVGGKKASGSGELRLRLAL 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356   139 EALKKgdkssSRPVLFLLDEFDLFAHHKNQTLLYNLLDVSQ----SAQTPVAVVGLTcrLDVLELLEKRVKSRFSHRQIH 214
Cdd:smart00382  72 ALARK-----LKPDVLILDEITSLLDAEQEALLLLLEELRLllllKSEKNLTVILTT--NDEKDLGPALLRRRFDRRIVL 144


                   .
gi 528481356   215 L 215
Cdd:smart00382 145 L 145
 
Name Accession Description Interval E-value
ORC4_C pfam14629
Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of ...
 226-413 7.75e-61

Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of origin recognition complex subunit 4.


Pssm-ID: 464223  Cd Length: 212  Bit Score: 196.79  E-value: 7.75e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356  226 DVVRLQLSLPQDF----PDHRFSSQWNQSVTKLCEDKSVLEVLKRSFNSSKDFRSLYSLLFMAVSRVSVSHSTLCEADFL 301
Cdd:pfam14629   1 EICKSLLSLPSDEssseGDKKFLEQWNASIEELLEDSTVQDILKRLYYTTKSVRSLLNSLILPVSKLSPDSPLLTAESLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356  302 ESGRLISADSKANVLHGLSILELCLIIAMKHLNDTYDGEPFNFQMVHNEFKKFIQRK-------------SHSIHKFEKP 368
Cdd:pfam14629  81 SALSSQSPDSKLSLLRSLSVLELCLLIAAARLSEIYDTDTFNFEMVYDEYKKLAKRSkvspssatsqssaASGIRVWGRP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 528481356  369 VVMKAFEHLLQLELVRPVD-------SGVCKVQREYQLMRLMLEHGQVMEAL 413
Cdd:pfam14629 161 VALKAWEHLLSLELLVPVGavstggaSSGSGGGKEFRMVRLDITLEEIREAV 212
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
31-224 6.04e-15

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 76.04  E-value: 6.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356  31 LPDQPIGLDSQYKHLLELLRrTAVHGES-NSVLIVGPRGSGKTMLLGCVLRELMS-LKEVQKNVLLVELNGLLQTDDKIA 108
Cdd:COG1474   24 VPDRLPHREEEIEELASALR-PALRGERpSNVLIYGPTGTGKTAVAKYVLEELEEeAEERGVDVRVVYVNCRQASTRYRV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356 109 LKEITRQLHLENVVGDKvfG-SFAENLAFLLEALKKGDksssRPVLFLLDEFDLFAHHKNQTLLYNLLDVSQS-AQTPVA 186
Cdd:COG1474  103 LSRILEELGSGEDIPST--GlSTDELFDRLYEALDERD----GVLVVVLDEIDYLVDDEGDDLLYQLLRANEElEGARVG 176

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 528481356 187 VVGLTCRLDVLELLEKRVKSRFSHRQIHlfsslsFSQY 224
Cdd:COG1474  177 VIGISNDLEFLENLDPRVKSSLGEEEIV------FPPY 208
TIGR02928 TIGR02928
orc1/cdc6 family replication initiation protein; Members of this protein family are found ...
 23-224 1.67e-11

orc1/cdc6 family replication initiation protein; Members of this protein family are found exclusively in the archaea. This set of DNA binding proteins shows homology to the origin recognition complex subunit 1/cell division control protein 6 family in eukaryotes. Several members may be found in genome and interact with each other. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274354 [Multi-domain]  Cd Length: 365  Bit Score: 65.35  E-value: 1.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356   23 RERLCHQKLPDQPIGLDSQYKHLLELLRrTAVHGE-SNSVLIVGPRGSGKTMLLGCVLRELMSL-KEVQKNVLLVELNgl 100
Cdd:TIGR02928   5 RDLLEPDYVPDRIVHRDEQIEELAKALR-PILRGSrPSNVFIYGKTGTGKTAVTKYVMKELEEAaEDRDVRVVTVYVN-- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356  101 LQTDDKI--ALKEITRQLhleNVVGDKV--FG-SFAENLAFLLEALKKGDKSssrpVLFLLDEFDLFAHHKNqTLLYNLL 175
Cdd:TIGR02928  82 CQILDTLyqVLVELANQL---RGSGEEVptTGlSTSEVFRRLYKELNERGDS----LIIVLDEIDYLVGDDD-DLLYQLS 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 528481356  176 ------DVSQSaqtPVAVVGLTCRLDVLELLEKRVKSRFSHRQIHlfsslsFSQY 224
Cdd:TIGR02928 154 rarsngDLDNA---KVGVIGISNDLKFRENLDPRVKSSLCEEEII------FPPY 199
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 44-211 7.24e-09

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 54.46  E-value: 7.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356  44 HLLELLRRTAVHGESNSVLIVGPRGSGKTMLLGCVLRElmsLKEVQKNVLLVELNGLLQTDdkialkeitrqlhlenvVG 123
Cdd:cd00009    5 EAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANE---LFRPGAPFLYLNASDLLEGL-----------------VV 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356 124 DKVFGSFAENLAFLLEALKKGDksssrpVLFlLDEFDLFAHHKNQTLLYNLLDVSQSAQTP--VAVVGLTCRLDVLELLE 201
Cdd:cd00009   65 AELFGHFLVRLLFELAEKAKPG------VLF-IDEIDSLSRGAQNALLRVLETLNDLRIDRenVRVIGATNRPLLGDLDR 137

                        170
                 ....*....|
gi 528481356 202 KRvKSRFSHR 211
Cdd:cd00009  138 AL-YDRLDIR 146
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 34-188 1.36e-08

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 54.05  E-value: 1.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356   34 QPIGLDSQYKHLLELLRRTAvHGESNSVLIVGPRGSGKTMLLGCVLRELMSLKEVQKNVLLVELNGLLQTDDKIALKEIT 113
Cdd:pfam13191   1 RLVGREEELEQLLDALDRVR-SGRPPSVLLTGEAGTGKTTLLRELLRALERDGGYFLRGKCDENLPYSPLLEALTREGLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356  114 RQLHLENVV----------------GDKVFGSFAENLAFLLEALKKGDKSSSRPVLFLLDEFDLFAHHkNQTLLYNLLDV 177
Cdd:pfam13191  80 RQLLDELESslleawraallealapVPELPGDLAERLLDLLLRLLDLLARGERPLVLVLDDLQWADEA-SLQLLAALLRL 158

                         170
                  ....*....|.
gi 528481356  178 SQsaQTPVAVV 188
Cdd:pfam13191 159 LE--SLPLLVV 167
cdc6 PRK00411
ORC1-type DNA replication protein;
39-229 1.74e-08

ORC1-type DNA replication protein;


Pssm-ID: 234751 [Multi-domain]  Cd Length: 394  Bit Score: 56.01  E-value: 1.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356  39 DSQYKHLLELLRrTAVHGESNS-VLIVGPRGSGKTMLLGCVLRELmslKEVQKNVLLVELNGllQTDD---KIaLKEITR 114
Cdd:PRK00411  36 EEQIEELAFALR-PALRGSRPLnVLIYGPPGTGKTTTVKKVFEEL---EEIAVKVVYVYINC--QIDRtryAI-FSEIAR 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356 115 QLHLENV--VG---DKVFGSFAEnlaflleALKKGDKsssrpVLFL-LDEFD-LFAHHKNQTLlYNLL---DVSQSAQtp 184
Cdd:PRK00411 109 QLFGHPPpsSGlsfDELFDKIAE-------YLDERDR-----VLIVaLDDINyLFEKEGNDVL-YSLLrahEEYPGAR-- 173

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 528481356 185 VAVVGLTCRLDVLELLEKRVKSRFSHRQIHlFSSLSFSQYVDVVR 229
Cdd:PRK00411 174 IGVIGISSDLTFLYILDPRVKSVFRPEEIY-FPPYTADEIFDILK 217
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 59-215 2.46e-08

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 52.76  E-value: 2.46e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356    59 NSVLIVGPRGSGKTMLLGCVLRElmsLKEVQKNVLLVELNGLLQTDDkialkeitRQLHLENVVGDKVFGSFAENLAFLL 138
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARE---LGPPGGGVIYIDGEDILEEVL--------DQLLLIIVGGKKASGSGELRLRLAL 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356   139 EALKKgdkssSRPVLFLLDEFDLFAHHKNQTLLYNLLDVSQ----SAQTPVAVVGLTcrLDVLELLEKRVKSRFSHRQIH 214
Cdd:smart00382  72 ALARK-----LKPDVLILDEITSLLDAEQEALLLLLEELRLllllKSEKNLTVILTT--NDEKDLGPALLRRRFDRRIVL 144


                   .
gi 528481356   215 L 215
Cdd:smart00382 145 L 145
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 61-212 1.56e-06

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 47.20  E-value: 1.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356   61 VLIVGPRGSGKTMLLGCVLRELmslkevqkNVLLVELNGLlqtddkialkEITrqlhlenvvgDKVFGSFAENLAFLLEA 140
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKEL--------GAPFIEISGS----------ELV----------SKYVGESEKRLRELFEA 52

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356  141 LKKgdkssSRPVLFLLDEFDLFAHHKN----------QTLLYNLLDVSQSAQTPVAVVGLTCRLDvleLLEKRVKSRFSH 210
Cdd:pfam00004  53 AKK-----LAPCVIFIDEIDALAGSRGsggdsesrrvVNQLLTELDGFTSSNSKVIVIAATNRPD---KLDPALLGRFDR 124


                  ..
gi 528481356  211 RQ 212
Cdd:pfam00004 125 II 126
AAA_22 pfam13401
AAA domain;
54-188 1.16e-04

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 41.56  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356   54 VHGESNSVLIVGPRGSGKTMLLgcvLRELMSLKEVQKNVLLVELNGllQTDDKIALKEITRQLHLEnvvgdkvfGSFAEN 133
Cdd:pfam13401   1 IRFGAGILVLTGESGTGKTTLL---RRLLEQLPEVRDSVVFVDLPS--GTSPKDLLRALLRALGLP--------LSGRLS 67

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 528481356  134 LAFLLEALKKGDKSSSRPVLFLLDEfdlfAHHKNQTLLYNLLDVSQSAQTPVAVV 188
Cdd:pfam13401  68 KEELLAALQQLLLALAVAVVLIIDE----AQHLSLEALEELRDLLNLSSKLLQLI 118
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
57-216 4.99e-04

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 42.48  E-value: 4.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356  57 ESNSVLIVGPRGSGKTMLLgcvlrelmslkevqKNVLLVELNGLLQTDDKIA----LKEITRQLHLENVVGDKVFGSFAE 132
Cdd:COG5635  179 KKKRLLILGEPGSGKTTLL--------------RYLALELAERYLDAEDPIPilieLRDLAEEASLEDLLAEALEKRGGE 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356 133 NLAFLLEALKKGdksssrPVLFLLDEFDLFAHHKNQTLLYNLLDVSQSAQTPVAVVgLTCR-----------LDVLELLE 201
Cdd:COG5635  245 PEDALERLLRNG------RLLLLLDGLDEVPDEADRDEVLNQLRRFLERYPKARVI-ITSRpegydsselegFEVLELAP 317

                        170
                 ....*....|....*
gi 528481356 202 krvksrFSHRQIHLF 216
Cdd:COG5635  318 ------LSDEQIEEF 326
ExeA COG3267
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, ...
 38-165 8.21e-04

Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442498 [Multi-domain]  Cd Length: 261  Bit Score: 40.93  E-value: 8.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356  38 LDSQYKHLLELLRRTAVHGESnSVLIVGPRGSGKTMLLGCVLRELMSlkevQKNVLLVeLNGLLQTDDkiALKEITRQLH 117
Cdd:COG3267   24 LSPSHREALARLEYALAQGGG-FVVLTGEVGTGKTTLLRRLLERLPD----DVKVAYI-PNPQLSPAE--LLRAIADELG 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 528481356 118 LENVVGDKVfgSFAENL-AFLLEALKKGdksssRPVLFLLDEfdlfAHH 165
Cdd:COG3267   96 LEPKGASKA--DLLRQLqEFLLELAAAG-----RRVVLIIDE----AQN 133
PTZ00112 PTZ00112
origin recognition complex 1 protein; Provisional
 58-224 9.23e-04

origin recognition complex 1 protein; Provisional


Pssm-ID: 240274 [Multi-domain]  Cd Length: 1164  Bit Score: 41.90  E-value: 9.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356   58 SNSVL-IVGPRGSGKTMLLGCVLrELMSLKEVQK---NVLLVELNGLLQTDDKIALKEITRQLHleNVVGDKVFGSFAen 133
Cdd:PTZ00112  780 SNQILyISGMPGTGKTATVYSVI-QLLQHKTKQKllpSFNVFEINGMNVVHPNAAYQVLYKQLF--NKKPPNALNSFK-- 854

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356  134 lafLLEALKKGDKSSSRPV-LFLLDEFDlFAHHKNQTLLYNLLDVSQSAQTPVAVVGLTCRLDVLELLEKRVKSRFShrq 212
Cdd:PTZ00112  855 ---ILDRLFNQNKKDNRNVsILIIDEID-YLITKTQKVLFTLFDWPTKINSKLVLIAISNTMDLPERLIPRCRSRLA--- 927

                         170
                  ....*....|..
gi 528481356  213 ihlFSSLSFSQY 224
Cdd:PTZ00112  928 ---FGRLVFSPY 936
PulE COG2804
Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell ...
 36-115 9.55e-04

Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442055 [Multi-domain]  Cd Length: 561  Bit Score: 41.33  E-value: 9.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356  36 IGLD-SQYKHLLELLRRTavHGesnSVLIVGPRGSGKTMLLGCVLRELMSlkeVQKNVLLVE------LNGLLQT--DDK 106
Cdd:COG2804  295 LGFSpDQLERLRRLIRRP--HG---IILVTGPTGSGKTTTLYAALNELNT---PERNIITVEdpveyqLPGINQVqvNPK 366

                         90
                 ....*....|....*
gi 528481356 107 I------ALKEITRQ 115
Cdd:COG2804  367 IgltfasALRSILRQ 381
COG1672 COG1672
Predicted ATPase, archaeal AAA+ ATPase superfamily [General function prediction only];
46-159 1.57e-03

Predicted ATPase, archaeal AAA+ ATPase superfamily [General function prediction only];


Pssm-ID: 441278 [Multi-domain]  Cd Length: 324  Bit Score: 40.28  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356  46 LELLRRTAVHGESNSVLIVGPRGSGKTMLlgcvlrelmsLKEVQKNVLLVELNgLLQTDDKIALKEITRQL--HLENVVG 123
Cdd:COG1672    9 LEELEKLYESDGGELVVVYGRRRVGKTSL----------IKEFLKEKPAIYFD-AREESERESLRDFSEALaeALGDPLS 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 528481356 124 DKVFGSFAENLAFLLEALKKgdksssRPVLFLLDEF 159
Cdd:COG1672   78 KKEFESWEEAFEYLAELAEG------KRLVIVIDEF 107
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
42-211 4.74e-03

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 38.33  E-value: 4.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356  42 YKHLLELLRRtavHGE--SNSVLIVGPRGSGKTMLLGCVLRELMslkevqKNVLLVELNGLLQTddkiALKEITRQLHle 119
Cdd:COG1223   20 ELRRRENLRK---FGLwpPRKILFYGPPGTGKTMLAEALAGELK------LPLLTVRLDSLIGS----YLGETARNLR-- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481356 120 nvvgdKVFgsfaenlafllealkkgDKSSSRPVLFLLDEFDLFAHHK-------------NQTLLYnlLDVSQSaqtPVA 186
Cdd:COG1223   85 -----KLF-----------------DFARRAPCVIFFDEFDAIAKDRgdqndvgevkrvvNALLQE--LDGLPS---GSV 137

                        170       180
                 ....*....|....*....|....*
gi 528481356 187 VVGLTCRldvLELLEKRVKSRFSHR 211
Cdd:COG1223  138 VIAATNH---PELLDSALWRRFDEV 159
COG3899 COG3899
Predicted ATPase [General function prediction only];
4-82 8.04e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 38.69  E-value: 8.04e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528481356    4 RRPAALSDVQCVSLVQELLRERLCHQKLPDQPIGLDSQYKHLLELLRRtAVHGESNSVLIVGPRGSGKTMLLGCVLREL 82
Cdd:COG3899   258 LAGAAALLLLGLLAAAAAGRRLLARRLIPQPLVGREAELAALLAALER-ARAGRGELVLVSGEAGIGKSRLVRELARRA 335
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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