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Conserved domains on  [gi|528485869|ref|XP_005166562|]
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katanin p80 WD40 repeat-containing subunit B1 isoform X1 [Danio rerio]

Protein Classification

WD repeat KATNB1 family protein( domain architecture ID 10078096)

WD repeat KATNB1 family protein similar to Mus musculus katanin p80 WD40 repeat-containing subunit B1 (KATNB1) that participates in a complex which severs microtubules in an ATP-dependent manner

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
9-289 1.31e-76

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 251.37  E-value: 1.31e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869   9 TSWKLQEIVAHSSNVSSLVLGkSSGRLLATGGEDCRVNIWAVSKPNCIMSLTGHTSAVGCIQFNSSEERVVAGSLSGSLR 88
Cdd:COG2319  109 TGLLLRTLTGHTGAVRSVAFS-PDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  89 LWDLEAAKILRTLMGHKASISSLDFHPMGEYLASGSVDSNIKLWDVRRKGCVFRYKGHTQAVRCLAFSPDGKWLASASDD 168
Cdd:COG2319  188 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869 169 STVKLWDLIAGKMITEFTSHTSAVNVVQFHPNEYLLASGSADRTVKLWDLEKFNMIGSSEGETGVVRSVLFNPDGSCLYS 248
Cdd:COG2319  268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 528485869 249 GSE-NTLRVYGWEPDRCFDVVHVGWGKVSDLAIS-NNQMIAVS 289
Cdd:COG2319  348 GSDdGTVRLWDLATGELLRTLTGHTGAVTSVAFSpDGRTLASG 390
Katanin_con80 pfam13925
con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein ...
 531-689 3.25e-70

con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein that binds to the N-terminal domain of katanin-p60, the catalytic ATPase. The complex associates with a specific subregion of the mitotic spindle leading to increased microtubule disassembly and targeting of p60 to the spindle poles. The assembly and function of the mitotic spindle requires the activity of a number of microtubule-binding proteins. Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. A proposed model is that katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein.


:

Pssm-ID: 464044  Cd Length: 160  Bit Score: 225.57  E-value: 3.25e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  531 KGHDTMCVMLSSRSKNLDSVRSVWASGDVKTSLDSAVSMNDLSIVVDVLNIINLKPSLWKLDLCTSILPQIEELLQSRYE 610
Cdd:pfam13925   1 KDHDTMLSVLQSRLLKLQVVRTLWRRNDIKGAIEAAVRMQDPSVLVDVLSVLQLKPELITLDLCVDLLPLLKELLKSKYE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  611 SYVQTGCMSLKLILKRFWPLISDTLNAPP-SVGVDITREERHQKCKACYKQLKNLSNVVKNRAEQVGRHGSTFRELQLLM 689
Cdd:pfam13925  81 RYIIVGLDFLRLILKNFGPVIKSALSAPPsSVGVDLSREERLEKCNECFKELQKIRQILKKLARRSGKLGELARELNLLL 160
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
9-289 1.31e-76

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 251.37  E-value: 1.31e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869   9 TSWKLQEIVAHSSNVSSLVLGkSSGRLLATGGEDCRVNIWAVSKPNCIMSLTGHTSAVGCIQFNSSEERVVAGSLSGSLR 88
Cdd:COG2319  109 TGLLLRTLTGHTGAVRSVAFS-PDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  89 LWDLEAAKILRTLMGHKASISSLDFHPMGEYLASGSVDSNIKLWDVRRKGCVFRYKGHTQAVRCLAFSPDGKWLASASDD 168
Cdd:COG2319  188 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869 169 STVKLWDLIAGKMITEFTSHTSAVNVVQFHPNEYLLASGSADRTVKLWDLEKFNMIGSSEGETGVVRSVLFNPDGSCLYS 248
Cdd:COG2319  268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 528485869 249 GSE-NTLRVYGWEPDRCFDVVHVGWGKVSDLAIS-NNQMIAVS 289
Cdd:COG2319  348 GSDdGTVRLWDLATGELLRTLTGHTGAVTSVAFSpDGRTLASG 390
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-292 4.14e-72

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 235.69  E-value: 4.14e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  13 LQEIVAHSSNVSSLVLGkSSGRLLATGGEDCRVNIWAVSKPNCIMSLTGHTSAVGCIQFNSSEERVVAGSLSGSLRLWDL 92
Cdd:cd00200    2 RRTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  93 EAAKILRTLMGHKASISSLDFHPMGEYLASGSVDSNIKLWDVRRKGCVFRYKGHTQAVRCLAFSPDGKWLASASDDSTVK 172
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869 173 LWDLIAGKMITEFTSHTSAVNVVQFHPNEYLLASGSADRTVKLWDLEKFNMIGSSEGETGVVRSVLFNPDGSCLYSGSE- 251
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEd 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 528485869 252 NTLRVYGWEPDRCfdvVHVGWG---KVSDLAISNNQMIAVSYSH 292
Cdd:cd00200  241 GTIRVWDLRTGEC---VQTLSGhtnSVTSLAWSPDGKRLASGSA 281
Katanin_con80 pfam13925
con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein ...
 531-689 3.25e-70

con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein that binds to the N-terminal domain of katanin-p60, the catalytic ATPase. The complex associates with a specific subregion of the mitotic spindle leading to increased microtubule disassembly and targeting of p60 to the spindle poles. The assembly and function of the mitotic spindle requires the activity of a number of microtubule-binding proteins. Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. A proposed model is that katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein.


Pssm-ID: 464044  Cd Length: 160  Bit Score: 225.57  E-value: 3.25e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  531 KGHDTMCVMLSSRSKNLDSVRSVWASGDVKTSLDSAVSMNDLSIVVDVLNIINLKPSLWKLDLCTSILPQIEELLQSRYE 610
Cdd:pfam13925   1 KDHDTMLSVLQSRLLKLQVVRTLWRRNDIKGAIEAAVRMQDPSVLVDVLSVLQLKPELITLDLCVDLLPLLKELLKSKYE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  611 SYVQTGCMSLKLILKRFWPLISDTLNAPP-SVGVDITREERHQKCKACYKQLKNLSNVVKNRAEQVGRHGSTFRELQLLM 689
Cdd:pfam13925  81 RYIIVGLDFLRLILKNFGPVIKSALSAPPsSVGVDLSREERLEKCNECFKELQKIRQILKKLARRSGKLGELARELNLLL 160
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 17-213 1.15e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 71.27  E-value: 1.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  17 VAHSSNVSSLVLGKSSGRLLATGGEDCRVNIWAVSKPNCIMSLTGHTSAVGCIQFNSSEERVVA-GSLSGSLRLWDLEAA 95
Cdd:PLN00181 529 LASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLAsGSDDGSVKLWSINQG 608

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  96 KILRTLMGhKASISSLDF-HPMGEYLASGSVDSNIKLWDVRR-KGCVFRYKGHTQAVRCLAFSpDGKWLASASDDSTVKL 173
Cdd:PLN00181 609 VSIGTIKT-KANICCVQFpSESGRSLAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKL 686

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 528485869 174 WDL-IAGKMITE-----FTSHTSAVNVVQFHPNEYLLASGSADRTV 213
Cdd:PLN00181 687 WDLsMSISGINEtplhsFMGHTNVKNFVGLSVSDGYIATGSETNEV 732
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 139-175 2.74e-12

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 61.56  E-value: 2.74e-12
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 528485869   139 CVFRYKGHTQAVRCLAFSPDGKWLASASDDSTVKLWD 175
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
139-175 4.04e-12

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 60.82  E-value: 4.04e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 528485869  139 CVFRYKGHTQAVRCLAFSPDGKWLASASDDSTVKLWD 175
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
9-289 1.31e-76

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 251.37  E-value: 1.31e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869   9 TSWKLQEIVAHSSNVSSLVLGkSSGRLLATGGEDCRVNIWAVSKPNCIMSLTGHTSAVGCIQFNSSEERVVAGSLSGSLR 88
Cdd:COG2319  109 TGLLLRTLTGHTGAVRSVAFS-PDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  89 LWDLEAAKILRTLMGHKASISSLDFHPMGEYLASGSVDSNIKLWDVRRKGCVFRYKGHTQAVRCLAFSPDGKWLASASDD 168
Cdd:COG2319  188 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869 169 STVKLWDLIAGKMITEFTSHTSAVNVVQFHPNEYLLASGSADRTVKLWDLEKFNMIGSSEGETGVVRSVLFNPDGSCLYS 248
Cdd:COG2319  268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 528485869 249 GSE-NTLRVYGWEPDRCFDVVHVGWGKVSDLAIS-NNQMIAVS 289
Cdd:COG2319  348 GSDdGTVRLWDLATGELLRTLTGHTGAVTSVAFSpDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
2-289 3.07e-75

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 247.90  E-value: 3.07e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869   2 ALTNTTITSWKLQEIVAHSSNVSSLVLgKSSGRLLATGGEDCRVNIWAVSKPNCIMSLTGHTSAVGCIQFNSSEERVVAG 81
Cdd:COG2319   60 LLLLDAAAGALLATLLGHTAAVLSVAF-SPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASG 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  82 SLSGSLRLWDLEAAKILRTLMGHKASISSLDFHPMGEYLASGSVDSNIKLWDVRRKGCVFRYKGHTQAVRCLAFSPDGKW 161
Cdd:COG2319  139 SADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869 162 LASASDDSTVKLWDLIAGKMITEFTSHTSAVNVVQFHPNEYLLASGSADRTVKLWDLEKFNMIGSSEGETGVVRSVLFNP 241
Cdd:COG2319  219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP 298

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 528485869 242 DGSCLYSGSE-NTLRVYGWEPDRCFDVVHVGWGKVSDLAIS-NNQMIAVS 289
Cdd:COG2319  299 DGKLLASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpDGKTLASG 348
WD40 COG2319
WD40 repeat [General function prediction only];
13-262 9.11e-75

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 246.36  E-value: 9.11e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  13 LQEIVAHSSNVSSLVLGkSSGRLLATGGEDCRVNIWAVSKPNCIMSLTGHTSAVGCIQFNSSEERVVAGSLSGSLRLWDL 92
Cdd:COG2319  155 LRTLTGHSGAVTSVAFS-PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  93 EAAKILRTLMGHKASISSLDFHPMGEYLASGSVDSNIKLWDVRRKGCVFRYKGHTQAVRCLAFSPDGKWLASASDDSTVK 172
Cdd:COG2319  234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869 173 LWDLIAGKMITEFTSHTSAVNVVQFHPNEYLLASGSADRTVKLWDLEKFNMIGSSEGETGVVRSVLFNPDGSCLYSGSE- 251
Cdd:COG2319  314 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAd 393

                        250
                 ....*....|.
gi 528485869 252 NTLRVygWEPD 262
Cdd:COG2319  394 GTVRL--WDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-292 4.14e-72

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 235.69  E-value: 4.14e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  13 LQEIVAHSSNVSSLVLGkSSGRLLATGGEDCRVNIWAVSKPNCIMSLTGHTSAVGCIQFNSSEERVVAGSLSGSLRLWDL 92
Cdd:cd00200    2 RRTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  93 EAAKILRTLMGHKASISSLDFHPMGEYLASGSVDSNIKLWDVRRKGCVFRYKGHTQAVRCLAFSPDGKWLASASDDSTVK 172
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869 173 LWDLIAGKMITEFTSHTSAVNVVQFHPNEYLLASGSADRTVKLWDLEKFNMIGSSEGETGVVRSVLFNPDGSCLYSGSE- 251
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEd 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 528485869 252 NTLRVYGWEPDRCfdvVHVGWG---KVSDLAISNNQMIAVSYSH 292
Cdd:cd00200  241 GTIRVWDLRTGEC---VQTLSGhtnSVTSLAWSPDGKRLASGSA 281
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-257 7.10e-71

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 232.23  E-value: 7.10e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869   4 TNTTITSWKLQE------IVAHSSNVSSLVLGkSSGRLLATGGEDCRVNIWAVSKPNCIMSLTGHTSAVGCIQFNSSEER 77
Cdd:cd00200   29 GDGTIKVWDLETgellrtLKGHTGPVRDVAAS-ADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  78 VVAGSLSGSLRLWDLEAAKILRTLMGHKASISSLDFHPMGEYLASGSVDSNIKLWDVRRKGCVFRYKGHTQAVRCLAFSP 157
Cdd:cd00200  108 LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869 158 DGKWLASASDDSTVKLWDLIAGKMITEFTSHTSAVNVVQFHPNEYLLASGSADRTVKLWDLEKFNMIGSSEGETGVVRSV 237
Cdd:cd00200  188 DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSL 267

                        250       260
                 ....*....|....*....|.
gi 528485869 238 LFNPDGSCLYSGSE-NTLRVY 257
Cdd:cd00200  268 AWSPDGKRLASGSAdGTIRIW 288
Katanin_con80 pfam13925
con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein ...
 531-689 3.25e-70

con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein that binds to the N-terminal domain of katanin-p60, the catalytic ATPase. The complex associates with a specific subregion of the mitotic spindle leading to increased microtubule disassembly and targeting of p60 to the spindle poles. The assembly and function of the mitotic spindle requires the activity of a number of microtubule-binding proteins. Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. A proposed model is that katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein.


Pssm-ID: 464044  Cd Length: 160  Bit Score: 225.57  E-value: 3.25e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  531 KGHDTMCVMLSSRSKNLDSVRSVWASGDVKTSLDSAVSMNDLSIVVDVLNIINLKPSLWKLDLCTSILPQIEELLQSRYE 610
Cdd:pfam13925   1 KDHDTMLSVLQSRLLKLQVVRTLWRRNDIKGAIEAAVRMQDPSVLVDVLSVLQLKPELITLDLCVDLLPLLKELLKSKYE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  611 SYVQTGCMSLKLILKRFWPLISDTLNAPP-SVGVDITREERHQKCKACYKQLKNLSNVVKNRAEQVGRHGSTFRELQLLM 689
Cdd:pfam13925  81 RYIIVGLDFLRLILKNFGPVIKSALSAPPsSVGVDLSREERLEKCNECFKELQKIRQILKKLARRSGKLGELARELNLLL 160
WD40 COG2319
WD40 repeat [General function prediction only];
18-289 1.08e-67

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 227.87  E-value: 1.08e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  18 AHSSNVSSLVLGKSSGRLLATGGEDCRVNIWAVSKPNCIMSLTGHTSAVGCIQFNSSEERVVAGSLSGSLRLWDLEAAKI 97
Cdd:COG2319   33 LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  98 LRTLMGHKASISSLDFHPMGEYLASGSVDSNIKLWDVRRKGCVFRYKGHTQAVRCLAFSPDGKWLASASDDSTVKLWDLI 177
Cdd:COG2319  113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869 178 AGKMITEFTSHTSAVNVVQFHPNEYLLASGSADRTVKLWDLEKFNMIGSSEGETGVVRSVLFNPDGSCLYSGSE-NTLRV 256
Cdd:COG2319  193 TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAdGTVRL 272

                        250       260       270
                 ....*....|....*....|....*....|....
gi 528485869 257 YGWEPDRCFDVVHVGWGKVSDLAIS-NNQMIAVS 289
Cdd:COG2319  273 WDLATGELLRTLTGHSGGVNSVAFSpDGKLLASG 306
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-217 9.18e-62

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 207.96  E-value: 9.18e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869   7 TITSWKLQ------EIVAHSSNVSSLVLgKSSGRLLATGGEDCRVNIWAVSKPNCIMSLTGHTSAVGCIQFNSSEERVVA 80
Cdd:cd00200   74 TIRLWDLEtgecvrTLTGHTSYVSSVAF-SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVAS 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  81 GSLSGSLRLWDLEAAKILRTLMGHKASISSLDFHPMGEYLASGSVDSNIKLWDVRRKGCVFRYKGHTQAVRCLAFSPDGK 160
Cdd:cd00200  153 SSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGY 232

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 528485869 161 WLASASDDSTVKLWDLIAGKMITEFTSHTSAVNVVQFHPNEYLLASGSADRTVKLWD 217
Cdd:cd00200  233 LLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
31-289 3.40e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 199.37  E-value: 3.40e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  31 SSGRLLATGGEDCRVNIWAVSKPNCIMSLTGHTSAVGCIQFNSSEERVVAGSLSGSLRLWDLEAAKILRTLMGHKASISS 110
Cdd:COG2319    4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869 111 LDFHPMGEYLASGSVDSNIKLWDVRRKGCVFRYKGHTQAVRCLAFSPDGKWLASASDDSTVKLWDLIAGKMITEFTSHTS 190
Cdd:COG2319   84 VAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869 191 AVNVVQFHPNEYLLASGSADRTVKLWDLEKFNMIGSSEGETGVVRSVLFNPDGSCLYSGSE-NTLRVYGWEPDRCFDVVH 269
Cdd:COG2319  164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSAdGTVRLWDLATGKLLRTLT 243

                        250       260
                 ....*....|....*....|.
gi 528485869 270 VGWGKVSDLAIS-NNQMIAVS 289
Cdd:COG2319  244 GHSGSVRSVAFSpDGRLLASG 264
WD40 COG2319
WD40 repeat [General function prediction only];
70-289 7.42e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.22  E-value: 7.42e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  70 QFNSSEERVVAGSLSGSLRLWDLEAAKILRTLMGHKASISSLDFHPMGEYLASGSVDSNIKLWDVRRKGCVFRYKGHTQA 149
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869 150 VRCLAFSPDGKWLASASDDSTVKLWDLIAGKMITEFTSHTSAVNVVQFHPNEYLLASGSADRTVKLWDLEKFNMIGSSEG 229
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528485869 230 ETGVVRSVLFNPDGSCLYSGSE-NTLRVYGWEPDRCFDVVHVGWGKVSDLAIS-NNQMIAVS 289
Cdd:COG2319  161 HSGAVTSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpDGKLLASG 222
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-292 3.75e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 132.07  E-value: 3.75e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869 139 CVFRYKGHTQAVRCLAFSPDGKWLASASDDSTVKLWDLIAGKMITEFTSHTSAVNVVQFHPNEYLLASGSADRTVKLWDL 218
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528485869 219 EKFNMIGSSEGETGVVRSVLFNPDGSCLYSGSE-NTLRVYGWEPDRCFDVV--HVGWgkVSDLAISNNQMIAVSYSH 292
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRdKTIKVWDVETGKCLTTLrgHTDW--VNSVAFSPDGTFVASSSQ 155
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 17-213 1.15e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 71.27  E-value: 1.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  17 VAHSSNVSSLVLGKSSGRLLATGGEDCRVNIWAVSKPNCIMSLTGHTSAVGCIQFNSSEERVVA-GSLSGSLRLWDLEAA 95
Cdd:PLN00181 529 LASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLAsGSDDGSVKLWSINQG 608

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  96 KILRTLMGhKASISSLDF-HPMGEYLASGSVDSNIKLWDVRR-KGCVFRYKGHTQAVRCLAFSpDGKWLASASDDSTVKL 173
Cdd:PLN00181 609 VSIGTIKT-KANICCVQFpSESGRSLAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKL 686

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 528485869 174 WDL-IAGKMITE-----FTSHTSAVNVVQFHPNEYLLASGSADRTV 213
Cdd:PLN00181 687 WDLsMSISGINEtplhsFMGHTNVKNFVGLSVSDGYIATGSETNEV 732
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 139-175 2.74e-12

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 61.56  E-value: 2.74e-12
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 528485869   139 CVFRYKGHTQAVRCLAFSPDGKWLASASDDSTVKLWD 175
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
139-175 4.04e-12

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 60.82  E-value: 4.04e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 528485869  139 CVFRYKGHTQAVRCLAFSPDGKWLASASDDSTVKLWD 175
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 19-218 7.30e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 68.96  E-value: 7.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  19 HSSNVSSLVLGKSSGRLLATGGEDCRVNIW---AVSKPN-----CIMSLTGHTSAVGCIQFNSSEERVVAGSLSGSLRLW 90
Cdd:PLN00181 481 NSSNLVCAIGFDRDGEFFATAGVNKKIKIFeceSIIKDGrdihyPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVW 560

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  91 DLEAAKILRTLMGHKASISSLDFHPMG-EYLASGSVDSNIKLWDVRRKGCVFRYKghTQA-VRCLAFSPD-GKWLASASD 167
Cdd:PLN00181 561 DVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIK--TKAnICCVQFPSEsGRSLAFGSA 638

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 528485869 168 DSTVKLWDLIAGKM-ITEFTSHTSAVNVVQFHPNEYLLASgSADRTVKLWDL 218
Cdd:PLN00181 639 DHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSSTLVSS-STDNTLKLWDL 689
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 120-257 6.14e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 62.41  E-value: 6.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869 120 LASGSVDSNIKLWDVRRKGCVFRYKGHTQAVRCLAFSP-DGKWLASASDDSTVKLWDLIAGKMITEFTSHTSaVNVVQFh 198
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQF- 625

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528485869 199 PNEY--LLASGSADRTVKLWDLEK-----FNMIGSSEgetgVVRSVLFNPDGSCLYSGSENTLRVY 257
Cdd:PLN00181 626 PSESgrSLAFGSADHKVYYYDLRNpklplCTMIGHSK----TVSYVRFVDSSTLVSSSTDNTLKLW 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 96-133 7.28e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 7.28e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 528485869    96 KILRTLMGHKASISSLDFHPMGEYLASGSVDSNIKLWD 133
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
96-133 1.32e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.89  E-value: 1.32e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 528485869   96 KILRTLMGHKASISSLDFHPMGEYLASGSVDSNIKLWD 133
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
112-293 1.85e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.31  E-value: 1.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869 112 DFHPMGEYLASGSVDSNIKLWDVRRKGCVFRYKGHTQAVRCLAFSPDGKWLASASDDSTVKLWDLIAGKMITEFTSHTSA 191
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869 192 VNVVQFHPNEYLLASGSADRTVKLWDLEKFNMIGSSEGETGVVRSVlfnpdgsclysgsentlrvygwepdrcfdvvhvg 271
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSV---------------------------------- 126

                        170       180
                 ....*....|....*....|....
gi 528485869 272 wgkvsdlAIS-NNQMIAV-SYSHT 293
Cdd:COG2319  127 -------AFSpDGKTLASgSADGT 143
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 179-217 2.14e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.09  E-value: 2.14e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 528485869   179 GKMITEFTSHTSAVNVVQFHPNEYLLASGSADRTVKLWD 217
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 15-171 3.19e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 60.10  E-value: 3.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  15 EIVAHSSNVSSLVLGKSSGRLLATGGEDCRVNIWAVSKPNCIMSLTGHTSaVGCIQFNSSEERVVA-GSLSGSLRLWDLE 93
Cdd:PLN00181 570 EMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSESGRSLAfGSADHKVYYYDLR 648

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  94 AAKI-LRTLMGHKASISSLDFHPmGEYLASGSVDSNIKLWDVR------RKGCVFRYKGHTQAVRCLAFSPDGKWLASAS 166
Cdd:PLN00181 649 NPKLpLCTMIGHSKTVSYVRFVD-SSTLVSSSTDNTLKLWDLSmsisgiNETPLHSFMGHTNVKNFVGLSVSDGYIATGS 727


                 ....*
gi 528485869 167 DDSTV 171
Cdd:PLN00181 728 ETNEV 732
WD40 pfam00400
WD domain, G-beta repeat;
179-217 9.69e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.19  E-value: 9.69e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 528485869  179 GKMITEFTSHTSAVNVVQFHPNEYLLASGSADRTVKLWD 217
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 71-271 1.05e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 58.37  E-value: 1.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  71 FNSSeeRVVAGSLSGSLRLWDLEAAKI-------LRTLMGHKASISSLDFHPMGE-YLASGSVDSNIKLWDVRRKGCVFR 142
Cdd:PTZ00421  86 FDPQ--KLFTASEDGTIMGWGIPEEGLtqnisdpIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEV 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869 143 YKGHTQAVRCLAFSPDGKWLASASDDSTVKLWDLIAGKMITEFTSHTSAVN--VVQFHPNEYLLASG---SADRTVKLWD 217
Cdd:PTZ00421 164 IKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSqrCLWAKRKDLIITLGcskSQQRQIMLWD 243

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 528485869 218 LEKFNMIGSSE--GETGVVRSVLFNPDGSCLYSGSENTLRVygwepdRCFDVVHVG 271
Cdd:PTZ00421 244 TRKMASPYSTVdlDQSSALFIPFFDEDTNLLYIGSKGEGNI------RCFELMNER 293
PTZ00420 PTZ00420
coronin; Provisional
 50-219 5.98e-08

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 55.73  E-value: 5.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  50 VSKPNCImSLTGHTSAVGCIQFNSSEERVVA-GSLSGSLRLWDL----EAAKILR----TLMGHKASISSLDFHPMGEY- 119
Cdd:PTZ00420  62 MRKPPVI-KLKGHTSSILDLQFNPCFSEILAsGSEDLTIRVWEIphndESVKEIKdpqcILKGHKKKISIIDWNPMNYYi 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869 120 LASGSVDSNIKLWDVRRKGCVFRYKgHTQAVRCLAFSPDGKWLASASDDSTVKLWDLIAGKMITEFTSHTSAVNVVQF-- 197
Cdd:PTZ00420 141 MCSSGFDSFVNIWDIENEKRAFQIN-MPKKLSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEIASSFHIHDGGKNTKNIwi 219

                        170       180
                 ....*....|....*....|....*....
gi 528485869 198 ----HPNEYLLASGSAD---RTVKLWDLE 219
Cdd:PTZ00420 220 dglgGDDNYILSTGFSKnnmREMKLWDLK 248
PTZ00420 PTZ00420
coronin; Provisional
 129-219 4.78e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 53.03  E-value: 4.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869 129 IKLWDVRRKGCVFRYKGHTQAVRCLAFSP-DGKWLASASDDSTVKLWDLIAG----KMITE----FTSHTSAVNVVQFHP 199
Cdd:PTZ00420  56 IRLENQMRKPPVIKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNdesvKEIKDpqciLKGHKKKISIIDWNP 135

                         90       100
                 ....*....|....*....|.
gi 528485869 200 -NEYLLASGSADRTVKLWDLE 219
Cdd:PTZ00420 136 mNYYIMCSSGFDSFVNIWDIE 156
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 52-91 6.64e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 6.64e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 528485869    52 KPNCIMSLTGHTSAVGCIQFNSSEERVVAGSLSGSLRLWD 91
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
54-91 1.49e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 1.49e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 528485869   54 NCIMSLTGHTSAVGCIQFNSSEERVVAGSLSGSLRLWD 91
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 36-228 2.14e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 50.66  E-value: 2.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  36 LATGGEDCRVNIWAVS----KPNC---IMSLTGHTSAVGCIQFNSSEERVVAGSLSGS-LRLWDLEAAKILRTLMGHKAS 107
Cdd:PTZ00421  91 LFTASEDGTIMGWGIPeeglTQNIsdpIVHLQGHTKKVGIVSFHPSAMNVLASAGADMvVNVWDVERGKAVEVIKCHSDQ 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869 108 ISSLDFHPMGEYLASGSVDSNIKLWDVRRKGCVFRYKGH--TQAVRCLafspdgkWL----------ASASDDSTVKLWD 175
Cdd:PTZ00421 171 ITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHasAKSQRCL-------WAkrkdliitlgCSKSQQRQIMLWD 243

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 528485869 176 L--IAGKMITEFTSHTSAVNVVQFHPNEYLLASGS-ADRTVKLWDLEKFNMIGSSE 228
Cdd:PTZ00421 244 TrkMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSkGEGNIRCFELMNERLTFCSS 299
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 145-193 1.54e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 43.81  E-value: 1.54e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 528485869  145 GHTQAVRCLAFSPDGKWLASASDDSTVKLWDLIAGKMITEFTSHTSAVN 193
Cdd:pfam12894  36 KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLIT 84
PTZ00420 PTZ00420
coronin; Provisional
 18-176 6.69e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.10  E-value: 6.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  18 AHSSNVSSLVLGKSSGRLLATGGEDCRVNIW----------AVSKPNCImsLTGHTSAVGCIQFNSSEERVVAGS-LSGS 86
Cdd:PTZ00420  72 GHTSSILDLQFNPCFSEILASGSEDLTIRVWeiphndesvkEIKDPQCI--LKGHKKKISIIDWNPMNYYIMCSSgFDSF 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  87 LRLWDLEAAK-ILRTLMGHKasISSLDFHPMGEYLASGSVDSNIKLWDVRRKGCVFRYKGHT--QAVRCL---AFSPDGK 160
Cdd:PTZ00420 150 VNIWDIENEKrAFQINMPKK--LSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEIASSFHIHDggKNTKNIwidGLGGDDN 227

                        170       180
                 ....*....|....*....|
gi 528485869 161 WLA----SASDDSTVKLWDL 176
Cdd:PTZ00420 228 YILstgfSKNNMREMKLWDL 247
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 34-185 8.03e-03

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 38.02  E-value: 8.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869   34 RLLATGGEDCRVNiwavskpnciMSLTGHTSAVgCIQFNSSEERVVAGSLSGSLRLWDLEAAKILRTlmgHKASISSLDF 113
Cdd:pfam08662  43 LIGETGGPDCVVE----------LDKEGPIHDV-AWSPNGKEFAVIYGYMPAKVSFFDLKGNVIHSF---GEQPRNTIFW 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528485869  114 HPMGEYLAS---GSVDSNIKLWDVRRKGCVFRYKgHTQAVRClAFSPDGKWLASASD------DSTVKLW----DLIAGK 180
Cdd:pfam08662 109 SPFGRLVLLagfGNLAGDIEFWDVVNKKKIATAE-ASNATLC-EWSPDGRYFLTATTaprlrvDNGFKIWhyngALVYKY 186


                  ....*
gi 528485869  181 MITEF 185
Cdd:pfam08662 187 DFDEL 191
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 153-204 8.46e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 39.64  E-value: 8.46e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 528485869  153 LAFSPDGKWLA-SASDDST---VKLWDLIAGKmITEFTSHTSAVNVVQFHPN-EYLL 204
Cdd:COG4946   437 LAWSPDSKWLAySKPGPNQlsqIFLYDVETGK-TVQLTDGRYDDGSPAFSPDgKYLY 492
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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