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Conserved domains on  [gi|528511459|ref|XP_005160643|]
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BTB/POZ domain-containing protein 7 isoform X1 [Danio rerio]

Protein Classification

BTB/POZ domain-containing protein 7( domain architecture ID 13033332)

BTB/POZ domain-containing protein 7 (BTBD7) acts as as a dynamic regulator of branching morphogenesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB2_POZ_BTBD7 cd18284
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 283-407 3.34e-71

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349593  Cd Length: 146  Bit Score: 233.00  E-value: 3.34e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  283 SPDEELRAHKAVLSARSPFFRNLLQRRIRSGEEiteRTLHTPTRIILDESIIPKKYARVVLHCMYTDAVDLSLVLRGSPS 362
Cdd:cd18284    25 EPDFELRCHKAILSARSPFFRNLLQRRIRTGED---RTLSTPTRIVLDESIIPRRYARVLLHAMYTDSVDLSLILRSSPS 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 528511459  363 EGSLGEVQALVAGRGCMSRAEEAMELYHIALFLEFSMLAQGCEDI 407
Cdd:cd18284   102 ESSLSEVQAIVAGKGPETRLEEAMELYHIARFLEFDILAQGCEDI 146
BACK_BTBD7 cd18489
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); ...
 412-509 1.06e-61

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains and a BACK domain.


:

Pssm-ID: 350564  Cd Length: 98  Bit Score: 204.85  E-value: 1.06e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  412 ISLDSVVAILKWSSQPYGSKWVHRQAMHFLCEEFSQVMTSDVLYELSKEHLLAAIQSDYLQASEQDILKYVVKWGEHQLI 491
Cdd:cd18489     1 LSLDTLVGILRWSSQPHGSQWVHRQALHFLREEFSQIAQSPVLFELTKEYLIEALQSDFLQASELDILKAVLKWGEHQLI 80

                          90
                  ....*....|....*...
gi 528511459  492 KRMADREPNLLSGTAHSV 509
Cdd:cd18489    81 KRMEEREPNLLSHTAHSV 98
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 139-230 3.22e-53

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 180.22  E-value: 3.22e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  139 YCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVLLDVGTAGMDAPMFSSLLHYLYTGELGSDDARLQNVDV 218
Cdd:cd18283     1 YCTDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPTAGIDVPMFSALLRYLYTGEFGSEDSRSQNLDV 80

                          90
                  ....*....|..
gi 528511459  219 LVRLSEEFGTPN 230
Cdd:cd18283    81 LIQLSEEFGTPN 92
 
Name Accession Description Interval E-value
BTB2_POZ_BTBD7 cd18284
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 283-407 3.34e-71

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349593  Cd Length: 146  Bit Score: 233.00  E-value: 3.34e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  283 SPDEELRAHKAVLSARSPFFRNLLQRRIRSGEEiteRTLHTPTRIILDESIIPKKYARVVLHCMYTDAVDLSLVLRGSPS 362
Cdd:cd18284    25 EPDFELRCHKAILSARSPFFRNLLQRRIRTGED---RTLSTPTRIVLDESIIPRRYARVLLHAMYTDSVDLSLILRSSPS 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 528511459  363 EGSLGEVQALVAGRGCMSRAEEAMELYHIALFLEFSMLAQGCEDI 407
Cdd:cd18284   102 ESSLSEVQAIVAGKGPETRLEEAMELYHIARFLEFDILAQGCEDI 146
BACK_BTBD7 cd18489
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); ...
 412-509 1.06e-61

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains and a BACK domain.


Pssm-ID: 350564  Cd Length: 98  Bit Score: 204.85  E-value: 1.06e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  412 ISLDSVVAILKWSSQPYGSKWVHRQAMHFLCEEFSQVMTSDVLYELSKEHLLAAIQSDYLQASEQDILKYVVKWGEHQLI 491
Cdd:cd18489     1 LSLDTLVGILRWSSQPHGSQWVHRQALHFLREEFSQIAQSPVLFELTKEYLIEALQSDFLQASELDILKAVLKWGEHQLI 80

                          90
                  ....*....|....*...
gi 528511459  492 KRMADREPNLLSGTAHSV 509
Cdd:cd18489    81 KRMEEREPNLLSHTAHSV 98
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 139-230 3.22e-53

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 180.22  E-value: 3.22e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  139 YCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVLLDVGTAGMDAPMFSSLLHYLYTGELGSDDARLQNVDV 218
Cdd:cd18283     1 YCTDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPTAGIDVPMFSALLRYLYTGEFGSEDSRSQNLDV 80

                          90
                  ....*....|..
gi 528511459  219 LVRLSEEFGTPN 230
Cdd:cd18283    81 LIQLSEEFGTPN 92
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 136-242 8.11e-14

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 68.44  E-value: 8.11e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459   136 QHKYCtDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPG--YGAEVLLDvgtaGMDAPMFSSLLHYLYTGELGSDDarl 213
Cdd:pfam00651    7 QGELC-DVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESesSVSEITLD----DVSPEDFEALLEFMYTGKLISEE--- 78

                           90       100
                   ....*....|....*....|....*....
gi 528511459   214 qNVDVLVRLSEEFGTPNSLEADMRNLCEH 242
Cdd:pfam00651   79 -NVDDLLAAADKLQIPSLVDKCEEFLIKS 106
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 142-242 1.25e-11

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 61.94  E-value: 1.25e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459    142 DVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYG--AEVLLDvgtaGMDAPMFSSLLHYLYTGELGSDDarlQNVDVL 219
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESdkSEIYLD----DVSPEDFRALLNFLYTGKLDLPE---ENVEEL 73

                            90       100
                    ....*....|....*....|...
gi 528511459    220 VRLSEEFGTPNSLEADMRNLCEH 242
Cdd:smart00225   74 LELADYLQIPGLVELCEEFLLKL 96
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 428-503 6.32e-11

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 60.05  E-value: 6.32e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528511459    428 YGSKWVHRQAMHFLCEEFSQVMTSDVLYELSKEHLLAAIQSDYLQ-ASEQDILKYVVKWGEHQLIKRMaDREPNLLS 503
Cdd:smart00875   11 HGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNvSSEEEVFEAVLRWVKHDPEKRR-EHLPELLE 86
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 285-412 2.26e-08

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 52.69  E-value: 2.26e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459    285 DEELRAHKAVLSARSPFFRNLLQRRIRSGEEitertlhtpTRIILDEsiIPKKYARVVLHCMYTDAVDLSlvlrgspseg 364
Cdd:smart00225    8 GKKFHAHKAVLAAHSPYFKALFSSDFKESDK---------SEIYLDD--VSPEDFRALLNFLYTGKLDLP---------- 66

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*...
gi 528511459    365 slgevqalvagrgcmsrAEEAMELYHIALFLEFSMLAQGCEDIVADSI 412
Cdd:smart00225   67 -----------------EENVEELLELADYLQIPGLVELCEEFLLKLL 97
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 428-493 1.03e-07

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 51.01  E-value: 1.03e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528511459   428 YGSKWVHRQAMHFLCEEFSQVMTSDVLYELSKEHLLAAIQSDYLQ-ASEQDILKYVVKWGEHQLIKR 493
Cdd:pfam07707   11 YGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNvPSEEEVFEAVIRWVKHDVERR 77
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 285-412 1.92e-07

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 50.33  E-value: 1.92e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459   285 DEELRAHKAVLSARSPFFRNLLQrrirSGEEItertlHTPTRIILDEsiIPKKYARVVLHCMYTDAVDlslvlrgspseg 364
Cdd:pfam00651   19 DKEFRAHKAVLAACSPYFKALFS----GQESE-----SSVSEITLDD--VSPEDFEALLEFMYTGKLI------------ 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 528511459   365 slgevqalvagrgcmsRAEEAMELYHIALFLEFSMLAQGCEDIVADSI 412
Cdd:pfam00651   76 ----------------SEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
 
Name Accession Description Interval E-value
BTB2_POZ_BTBD7 cd18284
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 283-407 3.34e-71

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349593  Cd Length: 146  Bit Score: 233.00  E-value: 3.34e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  283 SPDEELRAHKAVLSARSPFFRNLLQRRIRSGEEiteRTLHTPTRIILDESIIPKKYARVVLHCMYTDAVDLSLVLRGSPS 362
Cdd:cd18284    25 EPDFELRCHKAILSARSPFFRNLLQRRIRTGED---RTLSTPTRIVLDESIIPRRYARVLLHAMYTDSVDLSLILRSSPS 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 528511459  363 EGSLGEVQALVAGRGCMSRAEEAMELYHIALFLEFSMLAQGCEDI 407
Cdd:cd18284   102 ESSLSEVQAIVAGKGPETRLEEAMELYHIARFLEFDILAQGCEDI 146
BACK_BTBD7 cd18489
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); ...
 412-509 1.06e-61

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains and a BACK domain.


Pssm-ID: 350564  Cd Length: 98  Bit Score: 204.85  E-value: 1.06e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  412 ISLDSVVAILKWSSQPYGSKWVHRQAMHFLCEEFSQVMTSDVLYELSKEHLLAAIQSDYLQASEQDILKYVVKWGEHQLI 491
Cdd:cd18489     1 LSLDTLVGILRWSSQPHGSQWVHRQALHFLREEFSQIAQSPVLFELTKEYLIEALQSDFLQASELDILKAVLKWGEHQLI 80

                          90
                  ....*....|....*...
gi 528511459  492 KRMADREPNLLSGTAHSV 509
Cdd:cd18489    81 KRMEEREPNLLSHTAHSV 98
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 139-230 3.22e-53

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 180.22  E-value: 3.22e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  139 YCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVLLDVGTAGMDAPMFSSLLHYLYTGELGSDDARLQNVDV 218
Cdd:cd18283     1 YCTDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPTAGIDVPMFSALLRYLYTGEFGSEDSRSQNLDV 80

                          90
                  ....*....|..
gi 528511459  219 LVRLSEEFGTPN 230
Cdd:cd18283    81 LIQLSEEFGTPN 92
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 140-226 2.26e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 77.59  E-value: 2.26e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  140 CTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVLLDVGtaGMDAPMFSSLLHYLYTGELgsdDARLQNVDVL 219
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELD--DVSPEAFEALLDYIYTGEL---ELSEENVEEL 75


                  ....*..
gi 528511459  220 VRLSEEF 226
Cdd:cd18186    76 LAAADKL 82
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 136-242 8.11e-14

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 68.44  E-value: 8.11e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459   136 QHKYCtDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPG--YGAEVLLDvgtaGMDAPMFSSLLHYLYTGELGSDDarl 213
Cdd:pfam00651    7 QGELC-DVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESesSVSEITLD----DVSPEDFEALLEFMYTGKLISEE--- 78

                           90       100
                   ....*....|....*....|....*....
gi 528511459   214 qNVDVLVRLSEEFGTPNSLEADMRNLCEH 242
Cdd:pfam00651   79 -NVDDLLAAADKLQIPSLVDKCEEFLIKS 106
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 129-224 2.01e-13

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 67.24  E-value: 2.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  129 RDLATLYQHKYCTDVDLIFQDS-CFPAHRAILATRCPFFKTLLssspGYGAEVLLDvgtAGMDAPMFSSLLHYLYTGELG 207
Cdd:cd18299     1 EDLRNLLHSPSCADVVFILQGGvRIFAHRIVLAAASSVFADLF----LMMTVVTLD---SDITPEAFRRVLEFLYTGVLD 73

                          90
                  ....*....|....*..
gi 528511459  208 SDDARLQNVDVLVRLSE 224
Cdd:cd18299    74 ENEDDLKELKDAAELLE 90
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 142-242 1.25e-11

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 61.94  E-value: 1.25e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459    142 DVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYG--AEVLLDvgtaGMDAPMFSSLLHYLYTGELGSDDarlQNVDVL 219
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESdkSEIYLD----DVSPEDFRALLNFLYTGKLDLPE---ENVEEL 73

                            90       100
                    ....*....|....*....|...
gi 528511459    220 VRLSEEFGTPNSLEADMRNLCEH 242
Cdd:smart00225   74 LELADYLQIPGLVELCEEFLLKL 96
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 428-503 6.32e-11

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 60.05  E-value: 6.32e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528511459    428 YGSKWVHRQAMHFLCEEFSQVMTSDVLYELSKEHLLAAIQSDYLQ-ASEQDILKYVVKWGEHQLIKRMaDREPNLLS 503
Cdd:smart00875   11 HGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNvSSEEEVFEAVLRWVKHDPEKRR-EHLPELLE 86
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 127-234 1.70e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 59.56  E-value: 1.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  127 LQRDLATLYQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLssspgYG-------AEVLLDVGTAGmdapMFSSLLH 199
Cdd:cd18287     9 LSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALL-----YGgmresqqSEIELKDTNAE----AFKALLK 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 528511459  200 YLYTGELGSDDARLQNV-DVLvRLSEEFGTPnSLEA 234
Cdd:cd18287    80 YIYTGRLTLTDLKEDVLlDVL-GLAHQYGFE-ELEA 113
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 135-240 3.07e-10

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 58.12  E-value: 3.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  135 YQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVLLDVgtAGMDAPMFSSLLHYLYTGELgsdDARLQ 214
Cdd:cd18314     1 YNDSEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTL--EDVEPEIFETVLKYMYTGQV---TLSEE 75

                          90       100
                  ....*....|....*....|....*.
gi 528511459  215 NVDVLVRLSEEFGTPnsleaDMRNLC 240
Cdd:cd18314    76 NVLDLLMLASKYQVP-----DLEKLC 96
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 285-355 9.69e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 56.02  E-value: 9.69e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528511459  285 DEELRAHKAVLSARSPFFRNLLQRRIRSGEEitertlhtpTRIILDEsiIPKKYARVVLHCMYTDAVDLSL 355
Cdd:cd18186    10 GREFPAHRAVLAARSPYFRAMFSSGMKESSS---------SEIELDD--VSPEAFEALLDYIYTGELELSE 69
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 142-222 1.98e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 56.49  E-value: 1.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  142 DVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVLLDvgTAGMDAPMFSSLLHYLYTGELgsdDARLQNVDVLVR 221
Cdd:cd18295    21 DVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKREINLK--HPLVNPDAFRALLQYLYTGRL---EIHVDDVEDCKR 95


                  .
gi 528511459  222 L 222
Cdd:cd18295    96 L 96
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 126-205 2.59e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 56.24  E-value: 2.59e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  126 TLQRDLATLYQ---HKYCtDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVLLDVGTAGMDAPMFSSLLHYLY 202
Cdd:cd18309     4 TLEQDMEAFLEsvgGDFC-DITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMVPSRQAFDSLLRYIY 82


                  ...
gi 528511459  203 TGE 205
Cdd:cd18309    83 YGD 85
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 127-243 3.74e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 55.33  E-value: 3.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  127 LQRDLATLYQHKYCTDVDLIFQDSCFP--AHRAILATRCPFFKTLLSSSPGYGAE----VLLDVGTAgmdapMFSSLLHY 200
Cdd:cd18294     1 FAADMKSLINNPEFSDVKFLVGPERQEifAHKCILAARCEVFRAMFLTGPQKESTqsplVLSDIEPE-----VFRAVLEF 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 528511459  201 LYTGELGSDDArlQNVDVLVrLSEEFGTPnsleaDMRNLCEHM 243
Cdd:cd18294    76 IYTNCVTLSNH--TVIEVLA-AAVEYGLD-----ELRKLCERF 110
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 127-229 3.91e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 55.73  E-value: 3.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  127 LQRDLATLYQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSsspGYGAEV------LLDVGTAGMDApmfssLLHY 200
Cdd:cd18286     4 LGKDLLQLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLS---GSWAESnsseitLTGVSHAAVSF-----VLLF 75

                          90       100
                  ....*....|....*....|....*....
gi 528511459  201 LYTGELGSDDArlQNVDVLVRLSEEFGTP 229
Cdd:cd18286    76 IYGGVLDLPDD--VNLGELLSLADMYGLD 102
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 412-493 8.99e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 53.48  E-value: 8.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  412 ISLDSVVAILKWSsQPYGSKWVHRQAMHFLCEEFSQVMTSDVLYELSKEHLLAAIQSDYLQ-ASEQDILKYVVKWGEHQL 490
Cdd:cd18480     1 LDLSNCLQLLSFA-ESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNvPDEEAVLKAVLRWTKHDL 79


                  ...
gi 528511459  491 IKR 493
Cdd:cd18480    80 EAR 82
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 285-412 2.26e-08

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 52.69  E-value: 2.26e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459    285 DEELRAHKAVLSARSPFFRNLLQRRIRSGEEitertlhtpTRIILDEsiIPKKYARVVLHCMYTDAVDLSlvlrgspseg 364
Cdd:smart00225    8 GKKFHAHKAVLAAHSPYFKALFSSDFKESDK---------SEIYLDD--VSPEDFRALLNFLYTGKLDLP---------- 66

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*...
gi 528511459    365 slgevqalvagrgcmsrAEEAMELYHIALFLEFSMLAQGCEDIVADSI 412
Cdd:smart00225   67 -----------------EENVEELLELADYLQIPGLVELCEEFLLKLL 97
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 125-208 3.52e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 53.46  E-value: 3.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  125 RTLQRDLATLY---QHKYcTDVDLIFQDSC-FPAHRAILATRCPFFKTLLSS--------SPGYGAEVLLDVGTAGMDAp 192
Cdd:cd18310     1 KKLSSDLENLLdspDLFY-SDAEIIVEGGRpVPVHRCILAARSPFFRDIFASakaegantKPKLELRELIPGGIVGYDA- 78

                          90
                  ....*....|....*.
gi 528511459  193 mFSSLLHYLYTGELGS 208
Cdd:cd18310    79 -FMLVLSYLYSGRLRL 93
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 127-204 8.16e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 51.13  E-value: 8.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  127 LQRDLATLYQHKYCTDV--DLIFQ--DSCFPAHRAILATRCPFF-KTLLSSSPGYGAEVLLDVGT-AGMDAPMFSSLLHY 200
Cdd:cd18301     1 FQEDFKKLLDEADEGDNihDVVFQvgGKTFPAHKFILASRSDYFrKLFLSSLLTSEDAVGCDVVHiEKVPPEIFEQLLQF 80


                  ....
gi 528511459  201 LYTG 204
Cdd:cd18301    81 IYTD 84
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 428-493 1.03e-07

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 51.01  E-value: 1.03e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528511459   428 YGSKWVHRQAMHFLCEEFSQVMTSDVLYELSKEHLLAAIQSDYLQ-ASEQDILKYVVKWGEHQLIKR 493
Cdd:pfam07707   11 YGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNvPSEEEVFEAVIRWVKHDVERR 77
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 141-206 1.47e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 51.18  E-value: 1.47e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528511459  141 TDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVLLDVgtAGMDAPMFSSLLHYLYTGEL 206
Cdd:cd18280    15 ADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVI--EDVEPPVFKALLHFIYKDEL 78
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 285-412 1.92e-07

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 50.33  E-value: 1.92e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459   285 DEELRAHKAVLSARSPFFRNLLQrrirSGEEItertlHTPTRIILDEsiIPKKYARVVLHCMYTDAVDlslvlrgspseg 364
Cdd:pfam00651   19 DKEFRAHKAVLAACSPYFKALFS----GQESE-----SSVSEITLDD--VSPEDFEALLEFMYTGKLI------------ 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 528511459   365 slgevqalvagrgcmsRAEEAMELYHIALFLEFSMLAQGCEDIVADSI 412
Cdd:pfam00651   76 ----------------SEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 142-242 2.32e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 50.32  E-value: 2.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  142 DVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVLLDVGTAGMDApmFSSLLHYLYTGELgSDDARLQNVDVLVr 221
Cdd:cd18300    11 DVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKET--FLALLEYLYTDQA-PILEDGDCVGLIV- 86

                          90       100
                  ....*....|....*....|.
gi 528511459  222 LSEEFGTPNsleadMRNLCEH 242
Cdd:cd18300    87 LANRLCLPR-----LVALCEQ 102
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 138-242 2.71e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 50.14  E-value: 2.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  138 KYCtDVDLIFQDSCFPAHRAILATRCPFFKTLLSSspGYGAEVLLDVGTAGmdapMFSSLLHYLYTGELGSDDArlqNVD 217
Cdd:cd18232    17 QYC-DATLDVGGRVFKAHWSVLACCSHFFQSLYGD--GTSGSVVLPESFAE----VFGLLLDFFYTGELALTRE---NRD 86

                          90       100
                  ....*....|....*....|....*
gi 528511459  218 VLVRLSEEFGTPNSLEadmrnLCEH 242
Cdd:cd18232    87 RVLLAAKELRVPEAVE-----LCQR 106
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 138-226 4.05e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 49.63  E-value: 4.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  138 KYCtDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVLLDVgtAGMDAPMFSSLLHYLYTGELgsdDARLQNVD 217
Cdd:cd18240    16 KLC-DVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKI--PGVSPEMMELIIEYAYTRTV---PITAENVE 89


                  ....*....
gi 528511459  218 VLVRLSEEF 226
Cdd:cd18240    90 ELLPAADQF 98
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 127-216 4.07e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 50.10  E-value: 4.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  127 LQRDLATLYQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSS--SPGYGAEVLLDvgtaGMDAPMFSSLLHYLYTG 204
Cdd:cd18269    14 LQDGLKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSdlEESKKKEVVLE----DVDPDVMGMILKYLYTS 89

                          90
                  ....*....|..
gi 528511459  205 ELGSDDARLQNV 216
Cdd:cd18269    90 EIDLNDQNVQDI 101
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 142-234 4.96e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 49.83  E-value: 4.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  142 DVDLIFQDSCFPAHRAILATRCPFFKTL-LSSSPGYGAEVLLDVGTAGmdapMFSSLLHYLYTGELGSDdarLQNVDVLV 220
Cdd:cd18224    28 DVTIVVGNRSFAAHKAVLACAAGYFQKLfLSTELDVARTYVVDFITPA----NFEKVLSFIYTSELFTD---LINVGVIY 100

                          90
                  ....*....|....
gi 528511459  221 RLSEEFGTPNSLEA 234
Cdd:cd18224   101 EVAEKLGMEDLLKA 114
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 139-206 5.84e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 49.51  E-value: 5.84e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528511459  139 YCtDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVLLDVGTA-----------GMDAPMFSSLLHYLYTGEL 206
Cdd:cd18195    18 FC-DVTLIAGDTKFRAHRSVLAASSPYFRELLSSPLPLGAAAVAAAPGAtqspervlelpGVKAGVFSDVLNFIYSSRV 95
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 136-243 7.61e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 49.32  E-value: 7.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  136 QHKYCtDVDLIFQDSCFPAHRAILATRCPFFKTLLssSPGYGAEVLLDVGTAGMDAPMFSSLLHYLYTGELgsdDARLQN 215
Cdd:cd18256    17 QHEFC-DVQLQVGMELFSVHRLVLAASSPYFAALF--AGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVV---EVTVSN 90

                          90       100
                  ....*....|....*....|....*...
gi 528511459  216 VDVLVRLSEEFGTPNSLEADMRNLCEHM 243
Cdd:cd18256    91 VQELLVAADMLQLTEVVEICCEFLKGQL 118
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 127-240 9.26e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 48.49  E-value: 9.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  127 LQRDLATLYQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVLLDVGTAGMDAPMFSSLLHYLYTGE- 205
Cdd:cd18245     1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIELEGISVEVMEEILDYIYTGQi 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 528511459  206 -LGSDDAR--LQNVDVLvrlseefgtpnsLEADMRNLC 240
Cdd:cd18245    81 kLSEDNIQdiVQAADLL------------LMTDLKDLC 106
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 413-493 1.01e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 48.08  E-value: 1.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  413 SLDSVVAILKWSSQpYGSKWVHRQAMHFLCEEFSQVMTSDVLYELSKEHLLAAIQSDYLQA-SEQDILKYVVKWGEHQLI 491
Cdd:cd18455     1 SAENCIGIRDFAER-FSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVgNEEYIFEAVLRWVRHDPE 79


                  ..
gi 528511459  492 KR 493
Cdd:cd18455    80 ER 81
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 124-216 1.06e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 49.05  E-value: 1.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  124 ARTLQRDLATLYQHKYCTDVDL--------IFQDSCFPAHRAILATRCPFFKTLLSSspGYGAEVLLDVGTAGMDAPMFS 195
Cdd:cd18273    10 ARALLAQLKSFYDARLLTDVTIevngpgsgPGSGRLFPCNRNVLAAASPYFKSMFTG--GLYESKQETVTIHDVDSESMA 87

                          90       100
                  ....*....|....*....|.
gi 528511459  196 SLLHYLYTGELGSDDARLQNV 216
Cdd:cd18273    88 LIIDYCYTGRVTLSEANVQRL 108
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 124-224 1.19e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 48.84  E-value: 1.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  124 ARTLQRDLATLYQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSspGYGAEVLLDVGTAGMDAPMFSSLLHYLYT 203
Cdd:cd18270    10 AVSLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMS--GLSESKQTHVHLRNVDAATLQIIITYAYT 87

                          90       100       110
                  ....*....|....*....|....*....|.
gi 528511459  204 GELGSDDAR----------LQNVDVLVRLSE 224
Cdd:cd18270    88 GNLAINDSTveqlyetacfLQVEDVLQRCRE 118
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 124-241 2.54e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 47.28  E-value: 2.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  124 ARTLQRDLATLYQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGA---EVLLDVGTAGmdAPMFSSLLHY 200
Cdd:cd18292     1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSESkqsEIELVEDPEC--AAVFEKFLRY 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 528511459  201 LYTGELgsdDARLQNVDVLVRLSEEFGTpnsleADMRNLCE 241
Cdd:cd18292    79 LYTGQI---SVNLETALPLLMLADKYNV-----TDLKQLCV 111
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 127-234 2.96e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 47.47  E-value: 2.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  127 LQRDLATLYQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVLLDVgtAGMDAPMFSSLLHYLYTGEL 206
Cdd:cd18268    10 LLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDL--KGIDSDVLDQIVDYVYTGEI 87

                          90       100
                  ....*....|....*....|....*...
gi 528511459  207 gsdDARLQNVDVLVRLSEEFGTPNSLEA 234
Cdd:cd18268    88 ---LITRDNVLPLMEAASMLQYPKLFEA 112
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 127-216 5.67e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 46.76  E-value: 5.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  127 LQRDLATLYQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSS--SPGYGAEVLLD-VGTAGMDApmfssLLHYLYT 203
Cdd:cd18341    14 LQDGLKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSeeSEEKKKEVVLDnVDPNIMDM-----ILKYLYS 88

                          90
                  ....*....|...
gi 528511459  204 GELGSDDARLQNV 216
Cdd:cd18341    89 AEIDLNDGNVQDI 101
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 285-350 8.72e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 46.17  E-value: 8.72e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528511459  285 DEELRAHKAVLSARSPFFRNLLQRRIRSGEEitertlhtpTRIILDEsIIPKKYaRVVLHCMYTDA 350
Cdd:cd18280    23 GEKFRAHKLVLAARSPVFRSMLFGPMREENE---------GEIVIED-VEPPVF-KALLHFIYKDE 77
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 141-227 9.59e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 44.85  E-value: 9.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  141 TDVDLIFQDSCFPAHRAILATRCPFFKTLLSS-SPGYGAEVLLdvgtAGMDAPMFSSLLHYLYTGELgsdDARLQNVDVL 219
Cdd:cd18315     2 VDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIIL----PDVPYSELKALLDFIYTGEV---NVSQEQLESL 74


                  ....*...
gi 528511459  220 VRLSEEFG 227
Cdd:cd18315    75 LKLAELLQ 82
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 127-216 1.08e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 45.98  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  127 LQRDLATLYQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSS--PGYGAEVLLDvgtaGMDAPMFSSLLHYLYTG 204
Cdd:cd18340    14 LQDGLKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDleESKKREIVLE----DVDPDVMGKILHYIYTS 89

                          90
                  ....*....|..
gi 528511459  205 ELGSDDARLQNV 216
Cdd:cd18340    90 EIEITEQNVQDI 101
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 134-216 2.23e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 44.91  E-value: 2.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  134 LYQHKYCtDVDLIF--QDSCFPAHRAILATRCPFFKTLLSSSPGYG-AEVLLDVGTAGmdapMFSSLLHYLYTGELGSDD 210
Cdd:cd18231     9 LFQPDLC-DVDIVLvrQRSTFPAHKGVLAAYSQFFHSLFTQNKQLQrVELSLEALTSQ----GLQQILNFIYTSKLLVNS 83


                  ....*.
gi 528511459  211 ARLQNV 216
Cdd:cd18231    84 CNVQDV 89
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 142-216 2.29e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 44.79  E-value: 2.29e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528511459  142 DVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEV-LLDvgtaGMDAPMFSSLLHYLYTGELGSDDARLQNV 216
Cdd:cd18212    25 DITLIVENVQFRAHKALLAASSEYFSMMFADEGEVGQSIyMLE----GMVAETFGALLEFIYTGCLQVGEKSLEQI 96
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 124-234 4.43e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 43.99  E-value: 4.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  124 ARTLQRDLATLYQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSsspGYGAEVLLD-VGTAGMDAPMFSSLLHYLY 202
Cdd:cd18250     5 ALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFA---GELRESRADrVVLHGVSAEILGLLLDFSY 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 528511459  203 TGELgsdDARLQNVDVLVRLSEEFGTPNSLEA 234
Cdd:cd18250    82 TGRV---TVTQDNVEALLRAADLFQFPSVKEA 110
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 136-216 4.61e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 43.81  E-value: 4.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  136 QHKYCtDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPgygAEVLLD-VGTAGMDAPMFSSLLHYLYTGELGSDDARLQ 214
Cdd:cd18247    16 QGKLC-DVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDM---VESKQDeITMQGIEPSALEALINFAYSGRIAIDTSNVQ 91


                  ..
gi 528511459  215 NV 216
Cdd:cd18247    92 SL 93
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 413-468 6.20e-05

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 41.49  E-value: 6.20e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 528511459  413 SLDSVVAILKWSSQpYGSKWVHRQAMHFLCEEFSQVMTSDVLYELSKEHLLAAIQS 468
Cdd:cd14733     1 DPENCLGILELADL-YNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 141-218 6.43e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 43.64  E-value: 6.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  141 TDVDLIFQDSCFPAHRAILATRCPFFKTLLSSS--PGYGAEVLLdvgtAGMDAPMFSSLLHYLYTGELGSDDARLQNVDV 218
Cdd:cd18276    22 TDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGlmECSQREVVL----HDITAESVSIILNYMYSSDLHLTNSNVQGVAT 97
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 122-216 6.81e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 43.66  E-value: 6.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  122 PE-ARTLQRDLATLYQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVLL--DVGTagmdAPMFSSLL 198
Cdd:cd18194     4 PEhSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDRLDKRDLVRLnsDIVT----APAFGLLL 79

                          90
                  ....*....|....*...
gi 528511459  199 HYLYTGELGSDDARLQNV 216
Cdd:cd18194    80 DFMYEGRLALRDLPVEDV 97
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 285-355 7.10e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 42.72  E-value: 7.10e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528511459  285 DEELRAHKAVLSARSPFFRNLLQRRIRSGEEiTERTLHtptriILDESIIPKkyarvVLHCMYTDAVDLSL 355
Cdd:cd18314    15 DRKFFAHRIVLCARSPVFRSMLTGSMIESNL-KEVTLE-----DVEPEIFET-----VLKYMYTGQVTLSE 74
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 122-205 8.36e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 43.30  E-value: 8.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  122 PEARtLQRDLATLYQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSpgYGAEVLLDVGTAGMDAPMFSSLLHYL 201
Cdd:cd18345     1 PECR-LSDDLGLLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHE--MEERKQNRVEITDVDHEVMREMLRFI 77


                  ....
gi 528511459  202 YTGE 205
Cdd:cd18345    78 YTGK 81
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 119-204 1.03e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 43.07  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  119 LARPEARtLQRDLATLYQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVLLDVgtAGMDAPMFSSLL 198
Cdd:cd18343     1 LKVPECR-LAEDLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEI--NDVDPEVFKEMM 77


                  ....*.
gi 528511459  199 HYLYTG 204
Cdd:cd18343    78 RFIYTG 83
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 129-206 1.05e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 43.11  E-value: 1.05e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528511459  129 RDLATLYQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVllDVGTAGMDAPMFSSLLHYLYTGEL 206
Cdd:cd18336     8 RKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQE--EIKMEGVDPDALKALVHYAYTGVL 83
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 143-222 1.07e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 41.50  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  143 VDLIFQDSCFPAHRAILATRCPFFKTLLSSS---PGYgAEVLLDvgtaGMDAPMFSSLLHYLYTGELGSDDArlqNVDVL 219
Cdd:cd01165     1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGfreSGQ-AEINLR----DISPEDFRALLEFLYGGKRDLDAS---NLLEL 72


                  ...
gi 528511459  220 VRL 222
Cdd:cd01165    73 LEA 75
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 142-240 1.25e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 42.52  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  142 DVDLIFQDSCFPAHRAILATRCPFFKTLLSSspgygaEVLLDVGTAGMDAPMFSSLLHYLYTGELGSDDARLQNvdvlvr 221
Cdd:cd18216    22 DVIIVVENSLFRAHKNVLAASSGYFKSLVLH------DNLIHLDQDMVSPTVFQQILDFIYTGKLLDSLFEEPN------ 89

                          90       100
                  ....*....|....*....|
gi 528511459  222 LSEEFGTPNSLE-ADMRNLC 240
Cdd:cd18216    90 LSEVLAAANYLQlPDLAALC 109
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 141-206 1.31e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 42.51  E-value: 1.31e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528511459  141 TDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVLLDVGtaGMDAPMFSSLLHYLYTGEL 206
Cdd:cd18253    19 TDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEIN--GILAEAMDCFLQYVYTGKV 82
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 137-223 1.46e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 42.66  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  137 HKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGyGAEVLLDVGTagMDAPMFSSLLHYLYTGelGSDDARLQNV 216
Cdd:cd18351    21 NKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSNKPS-AENTCIEISY--VKYHIFQLVMQYLYCG--GTESLLIKNN 95


                  ....*..
gi 528511459  217 DVLVRLS 223
Cdd:cd18351    96 EIMELLS 102
BTB1_POZ_BTBD8 cd18285
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 127-203 1.64e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349594 [Multi-domain]  Cd Length: 104  Bit Score: 41.95  E-value: 1.64e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528511459  127 LQRDLATLYQHKYCTDVDLIFQDSCFPAHRAILATRCP-FFKTLLSSSPGYGAEVLLDVgtAGMDAPMFSSLLHYLYT 203
Cdd:cd18285     2 LSQDLLRLLREELHTDVTFYVGSTLFKAHKAILLARVPeFFSHIIGKLSSLEDQEPINI--ENLEASEFKTFLRQVYT 77
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 136-206 2.73e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 41.95  E-value: 2.73e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528511459  136 QHKYCtDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVlldvgTAGMDAPMFSSLLHYLYTGEL 206
Cdd:cd18290    24 QGLYC-DVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVEL-----PAAVQPQSFQQILSFCYTGRL 88
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 142-240 3.09e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 41.42  E-value: 3.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  142 DVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVL-LDVGTAGmdapMFSSLLHYLYTGELgsdDARLQNVDVLV 220
Cdd:cd18233    20 DCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSSQKNDVFhLDIKNVG----GIGQILDFMYTSHL---DLNQDNVQVML 92

                          90       100
                  ....*....|....*....|
gi 528511459  221 RLSEEFGTPNSLeadmrNLC 240
Cdd:cd18233    93 DIAQCLQVQNVL-----NMC 107
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 139-220 3.30e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 41.49  E-value: 3.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  139 YCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSspgygaEVLLDVGTAGMDAPMFSSLLHYLYTGE-LGSDDARLQNVD 217
Cdd:cd18334    20 FLCDVIIVVENALFRAHKNILAASSMYFKSLVLH------DNLINLDTDMVNPTVFRQILDFIYTGKlLTSDQPGEQNFN 93


                  ...
gi 528511459  218 VLV 220
Cdd:cd18334    94 ALL 96
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 122-204 3.41e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 41.36  E-value: 3.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  122 PEARtLQRDLATLYQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPgygAEVLLD-VGTAGMDAPMFSSLLHY 200
Cdd:cd18279     1 PECR-LAEDLGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEM---EESKKNrVEINDVDPEVFKEMMRF 76


                  ....
gi 528511459  201 LYTG 204
Cdd:cd18279    77 IYTG 80
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 126-241 3.58e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 41.48  E-value: 3.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  126 TLQRDLATLYQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPgygAEVLLD-VGTAGMDAPMFSSLLHYLYTG 204
Cdd:cd18344     9 MLTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEM---EERLKNpIEIHDLDPQVFKEMMGFIYTG 85

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 528511459  205 ELGSDDARLQNVDVLVRlSEEFGtpnsLEaDMRNLCE 241
Cdd:cd18344    86 KAPHLHSHSMACDVLAA-ADKYG----LE-GLKVLCE 116
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 140-229 3.71e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 40.56  E-value: 3.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  140 CTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGA-EVLLDVGTAGMDAPMFSSLLHYLYTGELGSDDarlQNVDV 218
Cdd:cd18307     1 FCDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMKATdELSITIDCDYLSPETVEQLLDYFYTGKIVISE---KNVED 77

                          90
                  ....*....|.
gi 528511459  219 LVRLSEEFGTP 229
Cdd:cd18307    78 LLKGAKYFNIP 88
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 434-503 4.08e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 40.86  E-value: 4.08e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528511459  434 HRQAMHFLCEEFSQVMTSDVLYELSKEHLLAAIQSDYLQA-SEQDILKYVVKWGEHQLIKRmADREPNLLS 503
Cdd:cd18468    21 HNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTkAEELVFETAIKWLKKDPKNR-KQHIAELLA 90
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 285-354 4.19e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 40.23  E-value: 4.19e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  285 DEELRAHKAVLSARSPFFRNLLqrrirsgeeiTERTLHTPTRIILDEsiIPKKYARVVLHCMYTDAVDLS 354
Cdd:cd18315    10 GGSLKAHKLVLAAASPYFAALL----------KETPPDEHPVIILPD--VPYSELKALLDFIYTGEVNVS 67
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 136-206 5.25e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 41.09  E-value: 5.25e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528511459  136 QHKYCtDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPgyGAEVLLDVGTAGMDAPMFSSLLHYLYTGEL 206
Cdd:cd18306    15 NRQFC-DVILQVGGHEIPAHRAVLACASPYLFELFSSDS--DGESILTVKLDGLDPDAVEVLVNYAYTSRL 82
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 437-496 5.76e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 40.12  E-value: 5.76e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528511459  437 AMHFLCEEFSQVMTSDVLYELSKEHLLAAIQSDYLQA-SEQDILKYVVKWGEHQLIKRMAD 496
Cdd:cd18516    25 ARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVeKEEDVFEAVMKWVGKDQEERTKA 85
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 139-206 6.17e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 40.54  E-value: 6.17e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528511459  139 YCtDVDLIFQDSCFPAHRAILATRCPFFKTLLSSS-PGYGAEVLLDVGtaGMDAPMFSSLLHYLYTGEL 206
Cdd:cd18293    15 FC-DVLLQAEGESVPAHCCVLSACSPYLTERLSSEpPPAGQKVVLELQ--GLKAHTLLKLVDFLYTSEL 80
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 290-316 6.39e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 40.01  E-value: 6.39e-04
                          10        20
                  ....*....|....*....|....*..
gi 528511459  290 AHKAVLSARSPFFRNLLQRRIRSGEEI 316
Cdd:cd18283    16 VHRAILSARCPFFRDLLSSSPGYGAEI 42
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 131-229 7.04e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 40.97  E-value: 7.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  131 LATLYQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSS--PGYGAEV-LLDVgtagmDAPMFSSLLHYLYTGELG 207
Cdd:cd18259    23 LQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDfvESISARVeIKDV-----DPAVMESLIDFAYTGKLT 97

                          90       100
                  ....*....|....*....|..
gi 528511459  208 SDDarlQNVDVLVRLSEEFGTP 229
Cdd:cd18259    98 INQ---GNVEALIRTSNRLQFP 116
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 132-243 8.20e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 40.38  E-value: 8.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  132 ATLYQHKYCTDVDLIFQDSCFPAHRAILATRCPF--FKTLLSSSPgygaevlLDVGTAGMDAPMfsSLLHYLYTGE--LG 207
Cdd:cd18303    10 ASLFDKELYSDITIKLADKSIPAHKFVLAARSEKwsNENLASTNE-------LDLSDISYEVVL--ALLRWLYTDEldLT 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 528511459  208 SDDARLQNvdvLVRLSEEFGTPnsleaDMRNLCEHM 243
Cdd:cd18303    81 LDDEFLLE---LMKAAKRFQLT-----DLVERCERA 108
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 131-203 1.05e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 39.83  E-value: 1.05e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528511459  131 LATLYQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVLLDVgtAGMDAPMFSSLLHYLYT 203
Cdd:cd18360     1 LGLFFNSPLLADVVFKIQGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPI--YGVSKDTFLSFLEYLYT 71
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 139-206 1.21e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 40.01  E-value: 1.21e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528511459  139 YCtDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVLLDVGTAgmdapMFSSLLHYLYTGEL 206
Cdd:cd18289    29 YC-DVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPATVPPA-----CFQQILSFCYTGKL 90
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 133-206 1.24e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 40.32  E-value: 1.24e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528511459  133 TLYQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPgygAEVLLD-VGTAGMDAPMFSSLLHYLYTGEL 206
Cdd:cd18244    23 ALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADM---RERDQDkIHLKGLTATGFSHVLQFMYYGTI 94
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 282-354 1.35e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 39.54  E-value: 1.35e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528511459  282 GSPDEELRAHKAVLSARSPFFRNLLQRRIRSGEeitertlhTPTRIILdESIIPKKYaRVVLHCMYTDAVDLS 354
Cdd:cd18294    22 GPERQEIFAHKCILAARCEVFRAMFLTGPQKES--------TQSPLVL-SDIEPEVF-RAVLEFIYTNCVTLS 84
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 285-373 1.89e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 39.16  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  285 DEELRAHKAVLSARSPFFRNLL--QRRIRSGEEIterTLHtptriildesIIPKKYARVVLHCMYTDAVDLslvlrgsPS 362
Cdd:cd18286    26 GKTFKAHRCILCARSSYFAAMLsgSWAESNSSEI---TLT----------GVSHAAVSFVLLFIYGGVLDL-------PD 85

                          90
                  ....*....|.
gi 528511459  363 EGSLGEVQALV 373
Cdd:cd18286    86 DVNLGELLSLA 96
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 141-219 1.92e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 38.89  E-value: 1.92e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528511459  141 TDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVllDVGTAGMDAPMFSSLLHYLYTGELgsdDARLQNVDVL 219
Cdd:cd18234     2 CDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEE--EIKLKDVDPDALWTLVQYCYTGRL---ELKEDNVESL 75
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 131-171 2.49e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 39.22  E-value: 2.49e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 528511459  131 LATLYQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLS 171
Cdd:cd18254    13 LNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFS 53
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 125-226 2.74e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 38.80  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  125 RTLQRDLATLYQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSP-GYGAEVLLDVGTAGMDAPMFSSLLHYLYT 203
Cdd:cd18258     2 KEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSrDSGGGEKLELTMSNINADVLELLLEFVYT 81

                          90       100
                  ....*....|....*....|...
gi 528511459  204 GELGSDDArlqNVDVLVRLSEEF 226
Cdd:cd18258    82 GSLIIDSA---NAKTLLEAANKF 101
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 412-489 2.81e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 37.59  E-value: 2.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  412 ISLDSVVAILKWSsQPYGSKWVHRQAMHFLCEEFSQV-MTSDVLYELSKEHLLAAIQSDYLQASEQDIL-KYVVKWGEHQ 489
Cdd:cd18450     1 LTPENCIGIRKFA-RYYFCPELERKAYRYILRNFEEVaKDSEEFLELSCEELEDIIEDDELNVKEEEVVfEAIVKWIDHD 79
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 142-224 2.90e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 38.76  E-value: 2.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  142 DVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVLLDVGTAGMDApmFSSLLHYLYTGELGSDDARLQNVDVLVR 221
Cdd:cd18326    27 DVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEA--LTALLDFAYTATLTVSTSNVGDILSAAR 104


                  ...
gi 528511459  222 LSE 224
Cdd:cd18326   105 LLE 107
BACK_BTBD19 cd18494
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); ...
 428-485 3.01e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.


Pssm-ID: 350569  Cd Length: 73  Bit Score: 37.29  E-value: 3.01e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 528511459  428 YGSKWVHRQAMHFLCEEFSQVMTSDVLYELSKEHLLAAIQSDYLQASEQDILKYVVKW 485
Cdd:cd18494    15 YGQDELKERCLAFIEEHTEEVFKTKGFHELSDEALSVILRSDKLRIDELDILKAVREW 72
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 131-206 3.31e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 38.30  E-value: 3.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  131 LATLYQH----KYCtDVDLIFQDSCFPAHRAILATRCPFF--KTLLSSSPgygAEVLLDVgtagMDAPMFSSLLHYLYTG 204
Cdd:cd18200     6 LETLNKHrlegKFC-DLSVHVQGRVFRAHKAVLAASSPYFhdKLLLNDTN---CLVLPSV----IEAAAFENLLQLIYSG 77


                  ..
gi 528511459  205 EL 206
Cdd:cd18200    78 RL 79
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 287-327 3.55e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 38.78  E-value: 3.55e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 528511459  287 ELRAHKAVLSARSPFFRNLLQrrirsgEEITERtLHTPTRI 327
Cdd:cd18344    34 EFRAHKAILAARSPVFRAMFE------HEMEER-LKNPIEI 67
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 142-212 3.82e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 38.23  E-value: 3.82e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528511459  142 DVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVLLDVgtAGMDAPMFSSLLHYLYTGEL---GSDDAR 212
Cdd:cd18223    20 DVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQEIWISSHVLEL--PDLKAEVFAEILNFIYSSKVvvkRQETVT 91
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 138-206 4.00e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 38.41  E-value: 4.00e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  138 KYCtDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVL-LDVGTagMDAPMFSSLLHYLYTGEL 206
Cdd:cd18207    26 RFC-DVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPReLEMHT--ISSKVFGDILDFAYTSRI 92
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 136-206 4.48e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 38.30  E-value: 4.48e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528511459  136 QHKYCtDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVLLDVGTAGMD-----APMFSSLLHYLYTGEL 206
Cdd:cd18228    16 EGHFC-DVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVLVSPAGKCVLDlhhvtVTGFAPLLEYAYTSTL 90
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 142-216 4.65e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 38.25  E-value: 4.65e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528511459  142 DVDLIFQDS--CFPAHRAILATRCPFFKTLLSSspGYGAEVLLDVGTAGMDAPMFSSLLHYLYTGELGSDDARLQNV 216
Cdd:cd18239    25 DVTLVPGDGdeTFPVHRAMMASASDYFKAMFTG--GMKEQELMCIKLHGVSKIGLKNIIDFIYTAKLSLNMDNLQDT 99
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 124-210 4.76e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 38.35  E-value: 4.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  124 ARTLQRDLATLYQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSspgygaEVLLDVGTAGMDAPMFSSLLHYLYT 203
Cdd:cd18333     5 SRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVVH------DNLINLDHEMVSPGIFRLILDYIYT 78


                  ....*..
gi 528511459  204 GELGSDD 210
Cdd:cd18333    79 GRLSEGD 85
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 287-319 4.91e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 38.83  E-value: 4.91e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 528511459  287 ELRAHKAVLSARSPFFRNLLQRRIRSGEEITER 319
Cdd:cd18310    30 PVPVHRCILAARSPFFRDIFASAKAEGANTKPK 62
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 436-488 5.17e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 37.40  E-value: 5.17e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 528511459  436 QAMHFLCEEFSQVMTSDVLYELSKEHLLAAIQSDYLQAS-EQDILKYVVKWGEH 488
Cdd:cd18485    24 RARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSrEESILDLVLRWVNH 77
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 142-219 5.45e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 38.18  E-value: 5.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  142 DVDLIFQDSCFPAHRAILATRCPFFKTLLSS--SPGYGAEVLLDvgtaGMDAPMFSSLLHYLYTGELGSDDarlQNVDVL 219
Cdd:cd18235    23 DVILVADGVEIPAHRVVLASCSPYFHAMFTGdlSESRANRVTLQ----DVDGKALLLLIDYVYTAEIQVTE---ENVQVL 95
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 126-219 5.69e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 37.76  E-value: 5.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  126 TLQRDLATLYQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEV---LLDVGTAGMDapmfsSLLHYLY 202
Cdd:cd18255     4 TLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDeieLKGVSAKGLK-----HILDFAY 78

                          90
                  ....*....|....*...
gi 528511459  203 TGELGSDdarLQNV-DVL 219
Cdd:cd18255    79 TSELTLD---LDCIqDVL 93
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 141-239 5.82e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 38.21  E-value: 5.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  141 TDVDLIFQDSCFPAHRAILATRCPFFKTLLSsspGYGAEVLLD-VGTAGMDAPMFSSLLHYLYTGELGSDDarlQNVDVL 219
Cdd:cd18265    24 TDVVLLVDGKDFPCHRATLSANSAYFRAMFG---GHLKESRQAvVEIQKVSAAAMEVLLDYMYGGGLRIQE---DNVESV 97

                          90       100
                  ....*....|....*....|
gi 528511459  220 VRLSEEFGTPNSLEADMRNL 239
Cdd:cd18265    98 LEASDLLQVSKLREACVRFL 117
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 152-241 5.84e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 37.64  E-value: 5.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  152 FPAHRAILATRCPFFKTLLSSSPGYGAEVLLDVGTagMDAPMFSSLLHYLYTGELGSDDARLQNVDVLVRLSEEFGTpNS 231
Cdd:cd18297    24 FYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPD--IRYDIFQLMMQYLYTGGVESLDVAQDDALELLRAASFFQL-DG 100

                          90
                  ....*....|
gi 528511459  232 LEADMRNLCE 241
Cdd:cd18297   101 LKRHCEILLS 110
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 124-216 7.57e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 37.52  E-value: 7.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  124 ARTLQRDLATLYQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSS--SPGYGAEVLLDvgtaGMDAPMFSSLLHYL 201
Cdd:cd18257     2 SEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGnlSEKENSEVEFQ----CIDETALQAIVEYA 77

                          90
                  ....*....|....*
gi 528511459  202 YTGELGSDDARLQNV 216
Cdd:cd18257    78 YTGTVFISQATVESL 92
BTB1_POZ_LZTR1 cd18308
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 126-243 8.27e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349617 [Multi-domain]  Cd Length: 156  Bit Score: 38.13  E-value: 8.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  126 TLQRDLATLYQHKYCTDVDLIFQDS--CFPAHRAILATRCPFFKTLL-----------------------SSSPGYGAEV 180
Cdd:cd18308     9 TLHDDFGRLLESRQFCDVEFIVGEEeeRIPAHIAFVAARSKWLRNKIlqarerqkqkaeqevedegseadSSSASKNDSP 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528511459  181 LLDVGTAGMDAPMFSSLLHYLYTGEL--GSDDARLQNVDVLV------RLSEEFGtpnsleadMRNLcEHM 243
Cdd:cd18308    89 MLEVRLPEADPEAFELILSFIYTDKIdpTRKGQDPGSNEVVLlmmdvyRLALQFQ--------MSRL-EQL 150
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 152-216 8.29e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 37.50  E-value: 8.29e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528511459  152 FPAHRAILATRCPFFKTLLSSSPGYGAEVLLDVGTagMDAPMFSSLLHYLYTGELGSDDARLQNV 216
Cdd:cd18323    35 FLAHRAVLASCSPFFHMFYKEQLDKRDLVCINNEI--VTAPAFSLLLEFMYEGRLSFNDTPVEDV 97
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 126-206 8.31e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 37.71  E-value: 8.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  126 TLQRDLATLYQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSpgygaevllDVGTAGMDAPMFSSLLHYLYTGE 205
Cdd:cd18243    18 NLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSIN---------NLVLQGCSSIGLRLVLEYLYTAN 88


                  .
gi 528511459  206 L 206
Cdd:cd18243    89 V 89
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 124-206 9.24e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 37.11  E-value: 9.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511459  124 ARTLQRDLATLYQHKYCTDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSpgygaevlldvGTAGMDAPM-----FSSLL 198
Cdd:cd18225     7 SRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDST-----------DTISIDASVvspeeFALLL 75


                  ....*...
gi 528511459  199 HYLYTGEL 206
Cdd:cd18225    76 EMVYTGKL 83
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 141-206 9.58e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 37.14  E-value: 9.58e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528511459  141 TDVDLIFQDSCFPAHRAILATRCPFFKTLLSSSPGYGAEVLLDVGtaGMDAPMFSSLLHYLYTGEL 206
Cdd:cd18332    20 TDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPS--GLEARGFQLLLDFMYTSRL 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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