BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219  155 LGRMIREDIYTDITINVNSEgNIRAHRAVLSSQSSVFRSMFSHNVKETDLSTINITDMSIQSFQTFINFLY-GNVNDEEF 233
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDK-EFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYtGKLISEEN 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 357495219  234 LMhrlDLLHAADKYDIYELREACQKSLQEDI 264
Cdd:pfam00651  80 VD---DLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219  155 LGRMIREDIYTDITINVNSEgNIRAHRAVLSSQSSVFRSMFSHNVKETDLSTINITDMSIQSFQTFINFLY-GNVNDEEF 233
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDK-EFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYtGKLISEEN 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 357495219  234 LMhrlDLLHAADKYDIYELREACQKSLQEDI 264
Cdd:pfam00651  80 VD---DLLAAADKLQIPSLVDKCEEFLIKSL 107

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219   166 DITINVnSEGNIRAHRAVLSSQSSVFRSMFSHNVKETDLSTINITDMSIQSFQTFINFLYGN--VNDEEFLMhrlDLLHA 243
Cdd:smart00225   1 DVTLVV-GGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGklDLPEENVE---ELLEL 76

                           90       100
                   ....*....|....*....|.
gi 357495219   244 ADKYDIYELREACQKSLQEDI 264
Cdd:smart00225  77 ADYLQIPGLVELCEEFLLKLL 97

BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor of Bruton's tyrosine kinase (Btk), thereby playing a role in B-cell development.

                         10        20
                 ....*....|....*....|....*....
gi 357495219 264 IDPKNVLERLQIASLYQLTTLKFSCMQYL 292
Cdd:cd18500    1 ITLRNVAELLEFADIYNADQLKESCLQFI 29

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219  155 LGRMIREDIYTDITINVNSEgNIRAHRAVLSSQSSVFRSMFSHNVKETDLSTINITDMSIQSFQTFINFLY-GNVNDEEF 233
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDK-EFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYtGKLISEEN 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 357495219  234 LMhrlDLLHAADKYDIYELREACQKSLQEDI 264
Cdd:pfam00651  80 VD---DLLAAADKLQIPSLVDKCEEFLIKSL 107

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219   166 DITINVnSEGNIRAHRAVLSSQSSVFRSMFSHNVKETDLSTINITDMSIQSFQTFINFLYGN--VNDEEFLMhrlDLLHA 243
Cdd:smart00225   1 DVTLVV-GGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGklDLPEENVE---ELLEL 76

                           90       100
                   ....*....|....*....|.
gi 357495219   244 ADKYDIYELREACQKSLQEDI 264
Cdd:smart00225  77 ADYLQIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219 153 ESLGRMIREDIYTDITINVNSEgNIRAHRAVLSSQSSVFRSMFSHNVKETDLSTINITDMSIQSFQTFINFLY-GNVNDE 231
Cdd:cd18344   12 DDLGELWENSLFTDCCLLVAGH-EFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYtGKAPHL 90

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 357495219 232 EFLMHRLDLLHAADKYDIYELREACQKSLQEDIDPKN 268
Cdd:cd18344   91 HSHSMACDVLAAADKYGLEGLKVLCEDALCRNLSVEN 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219 153 ESLGRMIREDIYTDITINVNSEgNIRAHRAVLSSQSSVFRSMFSHNVKETDLSTINITDMSIQSFQTFINFLY-GNVNDE 231
Cdd:cd18345    7 DDLGLLFERSAFSDVTLCVGGR-EFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYtGKAPNL 85

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 357495219 232 EFLMHrlDLLHAADKYDIYELREACQKSLQEDIDPKNV 269
Cdd:cd18345   86 DKMAD--DLLAAADKYALERLKVMCEEALCSNLSVENV 121

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219 157 RMIREDIYTDITINVNSeGNIRAHRAVLSSQSSVFRSMFSHNVKETDLSTINITDMSIQSFQTFINFLYGNVNDEEFLMH 236
Cdd:cd18286   10 QLFLNGEDSDITIKVDG-KTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLDLPDDVN 88

                         90       100
                 ....*....|....*....|....*...
gi 357495219 237 RLDLLHAADKYDIYELREACQKSLQEDI 264
Cdd:cd18286   89 LGELLSLADMYGLDGLKDVVAYTLRRDY 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219 164 YTDITINVnsEGN-IRAHRAVLSSQSSVFRSMFSHNVKETDLSTINITDMSIQSFQTFINFLY-GNVndEEFLMHR---L 238
Cdd:cd18297   12 MSDVTFLV--EGRpFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYtGGV--ESLDVAQddaL 87

                         90       100       110
                 ....*....|....*....|....*....|
gi 357495219 239 DLLHAADKYDIYELREACQKSLQEDIDPKN 268
Cdd:cd18297   88 ELLRAASFFQLDGLKRHCEILLSQQIDLDN 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219 142 FMQQRQNAAALESLGRMIRED-IYTDITINVNSEgNIRAHRAVLSSQSSVFRSMFSHNVKETDLSTINITDMSIQSFQTF 220
Cdd:cd18272    9 FTDRSHSSRVAQSIMDLCLEDgLFADVTISVEGK-EFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLL 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 357495219 221 INFLY-GNVN--DEEFlmhrLDLLHAADKYDIYELREACQKSLQEDIDPKNVLE 271
Cdd:cd18272   88 VDYIYhGTVKlrVEEL----QETYEVADMYQLTALFEECSRFLARTVQVRNCLQ 137

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219 139 PSGFMQQRQNaaaleslgrMIREDIYTDITINVnSEGNIRAHRAVLSSQSSVFRSMFSHNVKETDLSTINITDMSIQSFQ 218
Cdd:cd18237    5 LADFMGVMNN---------MRKQKTLCDVILIV-EGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIE 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 357495219 219 TFINFLYG---NVNDEEFlmhrLDLLHAADKYDIYELREACQKSLQEDIDPKNVL 270
Cdd:cd18237   75 LLVEFAYTariSVNSNNV----QSLLDAANQYQIEPVKKMCVDFLKEQLDASNCL 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219 142 FMQQRQNAAALESLGRMIREDIYTDITInVNSEGNIRAHRAVLSSQSSVFRSMFSHNVKETDLSTINITDMSIQSFQTFI 221
Cdd:cd18268    1 FKDQDLSSELLRQLNSLRQERILTDVIL-CTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIV 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 357495219 222 NFLYGNvndeEFLMHR---LDLLHAADKYDIYELREACQKSLQEDIDPKNVL 270
Cdd:cd18268   80 DYVYTG----EILITRdnvLPLMEAASMLQYPKLFEACSLYLQDQLTPENCL 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219 152 LESLGRMIREDIYTDITINVNSEgNIRAHRAVLSSQSSVFRSMFSHNVKETDLSTINITDMSIQSFQTFINFLY-GNVND 230
Cdd:cd18256    8 LAQLNKLRGQHEFCDVQLQVGME-LFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYtGVVEV 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 357495219 231 EEFLMHrlDLLHAADKYDIYELREACQKSLQEDIDPKNVL 270
Cdd:cd18256   87 TVSNVQ--ELLVAADMLQLTEVVEICCEFLKGQLHPSNCI 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219 152 LESLGRMIREDIYTDITINVNSEgNIRAHRAVLSSQSSVFRSMFSHNVKETDLSTINITDMSIQSFQTFINFLY-GNVND 230
Cdd:cd18250    9 LRGLSELRAERKFFDVTLCAGGR-EFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYtGRVTV 87

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 357495219 231 EEFLMHRldLLHAADKYDIYELREACQKSLQEDIDPKNV 269
Cdd:cd18250   88 TQDNVEA--LLRAADLFQFPSVKEACCAYLQQRLDVSNC 124

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219 165 TDITINVnsEG-NIRAHRAVLSSQSSVFRSMFSHNVKETDLSTINITDMSIQSFQTFINFLY-GNVNDEEFLMHrlDLLH 242
Cdd:cd18352   14 SDVTFLV--EGrRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYtGSVDITNDIAK--DLLR 89

                         90       100
                 ....*....|....*....|....*..
gi 357495219 243 AADKYDIYELREACQKSLQEDIDPKNV 269
Cdd:cd18352   90 AADQYLLEGLKRLCEYTIAQDLTLENI 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219 152 LESLGRMIREDIYTDITINVNSEgNIRAHRAVLSSQSSVFRSMFSHNVKETDLSTINITD-MSIQSFQTFINFLYGN--- 227
Cdd:cd18254   10 LTHLNTLRKQCMFTDVTLWAGNR-SFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHDsLHPEVLELLLDFAYSSrii 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 357495219 228 VNDEeflmHRLDLLHAADKYDIYELREACQKSLQEDIDPKNVL 270
Cdd:cd18254   89 INEE----NAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCL 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219 152 LESLGRMIREDIYTDITINVNSEgNIRAHRAVLSSQSSVFRSMFSH-NVKETDLSTINIT--DMSIQSFQTFINFLYGN- 227
Cdd:cd18292    5 LQDIAQLYNNEELSDIVLRVGGK-VFHAHRLILAKSSDVFRVMLSNdWWSESKQSEIELVedPECAAVFEKFLRYLYTGq 83

                         90       100       110
                 ....*....|....*....|....*....|....
gi 357495219 228 --VNDEEFL-MHRLdllhaADKYDIYELREACQK 258
Cdd:cd18292   84 isVNLETALpLLML-----ADKYNVTDLKQLCVD 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219 145 QRQNAAALESLGRMIREDIYTDITINVNSEgNIRAHRAVLSSQSSVFRSMFSHNVKETDLSTINITDMSIQSFQTFINFL 224
Cdd:cd18246   20 KRHYHDAFVSMNRMRQRGLLCDIVLHVGTK-EIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYA 98

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 357495219 225 Y--------GNVNdeeflmhrlDLLHAADKYDIYELREACQKSLQEDIDP 266
Cdd:cd18246   99 YtaeivvgeGNVQ---------TLLPAASLLQLNGVRDACCKFLLSQLDP 139

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219 146 RQNAAALESLgRMIREdiYTDITINVNSEgNIRAHRAVLSSQSSVFRSMFSHNVKETDLSTINITDMSIQSFQTFINFLY 225
Cdd:cd18249    8 RQTLEAINLL-RKHRE--LCDVVLVVGAK-KIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAY 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 357495219 226 --------GNVNdeeflmhrlDLLHAADKYDIYELREACQKSLQEDIDPKNVL 270
Cdd:cd18249   84 tsqitveeGNVQ---------TLLPAACLLQLAEIQEVCCEFLKRQLDPSNCL 127

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219 153 ESLGRMIREDIYTDITINVNSEGNIRAHRAVLSSQSSVFRSMFSHnvketdLSTINIT-DMSIQSFQTFINFLY-GNVN- 229
Cdd:cd18299    1 EDLRNLLHSPSCADVVFILQGGVRIFAHRIVLAAASSVFADLFLM------MTVVTLDsDITPEAFRRVLEFLYtGVLDe 74

                         90       100
                 ....*....|....*....|....*..
gi 357495219 230 DEEFLMHrldLLHAADKYDIYELREAC 256
Cdd:cd18299   75 NEDDLKE---LKDAAELLELFDLVMMC 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219 147 QNAAALESLGRMIREDIYTDITINVNSEgNIRAHRAVLSSQSSVFRSMFSHNVKETDLSTINITDMSIQSFQTFINFLYG 226
Cdd:cd18306    1 HPESVLAKLNALRKNRQFCDVILQVGGH-EIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYT 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 357495219 227 ---NVNDEeflmHRLDLLHAADKYDIYELREACQKSLQEDIDPKNVLE 271
Cdd:cd18306   80 srlEVPAD----LVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIG 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219 149 AAALESLGRMIREDIYTDITINVNSEGNIRA-------HRAVLSSQSSVFRSMFSHNVKETDLSTINITDMSIQSFQTFI 221
Cdd:cd18273   11 RALLAQLKSFYDARLLTDVTIEVNGPGSGPGsgrlfpcNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSESMALII 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 357495219 222 NFLY-GNVNDEEFLMHRldLLHAADKYDIYELREACQKSLQEDIDPKN 268
Cdd:cd18273   91 DYCYtGRVTLSEANVQR--LYAAANMLQLEYVREACASFLARRLDLSN 136

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219 151 ALESLGRMIREDIYTDITInVNSEGNIRAHRAVLSSQSSVFRSMFSHNVKETDLSTINITDMSIQSFQTFINFLYG---N 227
Cdd:cd18235    8 AFDVMNELRKQNLLCDVIL-VADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVYTaeiQ 86

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 357495219 228 VNDEEFLMhrldLLHAADKYDIYELREACQKSLQEDIDP 266
Cdd:cd18235   87 VTEENVQV----LLPAANLLQLTDVRDACCDFLQSQLHP 121

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219 160 REDIYtDITINVNSEGNIRAHRAVLSSQSSVFRSMFSHNVKETdlSTINITDMSIQS--FQTFINFLYGNVN-------D 230
Cdd:cd18302    2 HSDLY-DVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEA--SSCSALTMPIPSdiLEIILDYLYTDEAsavkesqN 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 357495219 231 EEFLMhrlDLLHAADKYDIYELREACQKSLQEDIDPKN 268
Cdd:cd18302   79 VEFLC---NVLVIADQLLITRLKEICEVALVELLSLKN 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219 151 ALESLGRMIREDIYTDITInVNSEGNIRAHRAVLSSQSSVFRSMFSHNVKETDLSTINITDMSIQSFQTFINFLYG---N 227
Cdd:cd18339    8 AFKVMNELRSKQLLCDVTI-VAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTaeiE 86

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 357495219 228 VNDEEFLMhrldLLHAADKYDIYELREACQKSLQEDIDP 266
Cdd:cd18339   87 VTEENVQV----LLPAASLLQLMDVRQNCCDFLQSQLHP 121

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219 164 YTDITINVNSEgNIRAHRAVLSSQSSVFRSMFSHNVKETDLSTINITDM--SIQSFQTFINFLY-GNVNdeeflMHRLDL 240
Cdd:cd18309   20 FCDITLLLDGH-PIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMvpSRQAFDSLLRYIYyGDVT-----MPPEDS 93

                         90       100       110
                 ....*....|....*....|....*....|...
gi 357495219 241 LHAADKYDIY-----ELREACQKSLQEDIDPKN 268
Cdd:cd18309   94 LYLFSAPYFYgftnnRLQAYCKQNLEMNVSFEN 126

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357495219 152 LESLGRMIREDIYTDITINVNSEGnIRAHRAVLSSQSSVFRSMFSHNVKETDLSTINITDMSIQSFQTFINFLY------ 225
Cdd:cd18255    6 LQGLNALRAKGQLLDVTLIADGQR-FQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYtseltl 84