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Conserved domains on  [gi|357450327|ref|XP_003595440|]
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pyruvate dehydrogenase (acetyl-transferring) kinase, mitochondrial isoform X1 [Medicago truncatula]

Protein Classification

PDK/BCKDK family protein kinase( domain architecture ID 13768654)

PDK/BCKDK family protein kinase contains a histidine kinase-like ATPase domain and catalyzes the phosphorylation of protein substrates, such as branched-chain alpha-ketoacid dehydrogenase (BCKD) kinase that catalyzes the phosphorylation and inactivation of the BCKD complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways

CATH:  3.30.565.10|1.20.140.20
EC:  2.7.11.-
Gene Ontology:  GO:0004672|GO:0005524|GO:0006468
PubMed:  10339418|10637609

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 193-359 6.29e-78

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


:

Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 236.85  E-value: 6.29e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 193 SPVEVARNAVDDARSICSRQYGSAPDVHIYGDPDFTFPYVPAHLHLMVFELVKNSLRAVEERYMNSDKDPPPIRIIVADG 272
Cdd:cd16929    1 SPKKVVEDASEEARVLCDDYYLSSPELEIEGDPSIRFPYVPSHLYYILFELLKNAMRATVESHGDDSDDLPPIKVTVAKG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 273 LEDVTIKISDEGGGIPRSGLRKIFTYLYSTARNPL--DEHADLGVGDNVTMAGYGYGLPISRLYARYFGGDLQIISMENY 350
Cdd:cd16929   81 DEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPSldDFSDLISGTQPSPLAGFGYGLPMSRLYAEYFGGDLDLQSMEGY 160


                 ....*....
gi 357450327 351 GTDAYLHLS 359
Cdd:cd16929  161 GTDVYIYLK 169
BCDHK_Adom3 pfam10436
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ...
 28-189 3.40e-69

Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.


:

Pssm-ID: 463093  Cd Length: 158  Bit Score: 214.29  E-value: 3.40e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327   28 GVSLRYMMDFGSKPTSKNLLISAQFLHKELAIRIARRAVELERLPCDLSQKPAVLKVRDWYLDSFRDIRSFSEIKnMNDE 107
Cdd:pfam10436   1 PLSLRQLLDFGRSLSEEKLLKSANFLREELPVRLAHRIRELQNLPYILVSNPSISKVYEWYLQSFEELLSFPPPI-LEDN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327  108 KEFTEVIKAIKVRHNNVVPTMALGVQQLKKDVDPKiinqdfvEIHQFLDRFYMSRIGIRMLIGQHVELH----SPNPPPH 183
Cdd:pfam10436  80 EKFTELLEEILDRHNDVVPTLAQGVLELKKYLSPE-------EIQSFLDRFLRSRIGIRLLAEQHIALTeqsnNPSHPPD 152


                  ....*.
gi 357450327  184 VVGYIH 189
Cdd:pfam10436 153 YVGIID 158
 
Name Accession Description Interval E-value
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 193-359 6.29e-78

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 236.85  E-value: 6.29e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 193 SPVEVARNAVDDARSICSRQYGSAPDVHIYGDPDFTFPYVPAHLHLMVFELVKNSLRAVEERYMNSDKDPPPIRIIVADG 272
Cdd:cd16929    1 SPKKVVEDASEEARVLCDDYYLSSPELEIEGDPSIRFPYVPSHLYYILFELLKNAMRATVESHGDDSDDLPPIKVTVAKG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 273 LEDVTIKISDEGGGIPRSGLRKIFTYLYSTARNPL--DEHADLGVGDNVTMAGYGYGLPISRLYARYFGGDLQIISMENY 350
Cdd:cd16929   81 DEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPSldDFSDLISGTQPSPLAGFGYGLPMSRLYAEYFGGDLDLQSMEGY 160


                 ....*....
gi 357450327 351 GTDAYLHLS 359
Cdd:cd16929  161 GTDVYIYLK 169
BCDHK_Adom3 pfam10436
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ...
 28-189 3.40e-69

Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.


Pssm-ID: 463093  Cd Length: 158  Bit Score: 214.29  E-value: 3.40e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327   28 GVSLRYMMDFGSKPTSKNLLISAQFLHKELAIRIARRAVELERLPCDLSQKPAVLKVRDWYLDSFRDIRSFSEIKnMNDE 107
Cdd:pfam10436   1 PLSLRQLLDFGRSLSEEKLLKSANFLREELPVRLAHRIRELQNLPYILVSNPSISKVYEWYLQSFEELLSFPPPI-LEDN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327  108 KEFTEVIKAIKVRHNNVVPTMALGVQQLKKDVDPKiinqdfvEIHQFLDRFYMSRIGIRMLIGQHVELH----SPNPPPH 183
Cdd:pfam10436  80 EKFTELLEEILDRHNDVVPTLAQGVLELKKYLSPE-------EIQSFLDRFLRSRIGIRLLAEQHIALTeqsnNPSHPPD 152


                  ....*.
gi 357450327  184 VVGYIH 189
Cdd:pfam10436 153 YVGIID 158
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 233-358 3.49e-18

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 79.23  E-value: 3.49e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327   233 PAHLHLMVFELVKNSLRAVEERymnsdkdpPPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTArnpldehad 312
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTPEG--------GRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTD--------- 65

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 357450327   313 lgvGDNVTMAGYGYGLPISRLYARYFGGDLQIISMENYGTDAYLHL 358
Cdd:smart00387  66 ---KRSRKIGGTGLGLSIVKKLVELHGGEISVESEPGGGTTFTITL 108
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 232-358 1.66e-16

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 74.71  E-value: 1.66e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327  232 VPAHLHLMVFELVKNSLRAVEErymnsdkdPPPIRIIVADGlEDVTIKISDEGGGIPRSGLRKIFTYLYStarnpldeha 311
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAK--------AGEITVTLSEG-GELTLTVEDNGIGIPPEDLPRIFEPFST---------- 62

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 357450327  312 dlgvGDNVTMAGYGYGLPISRLYARYFGGDLQIISMENYGTDAYLHL 358
Cdd:pfam02518  63 ----ADKRGGGGTGLGLSIVRKLVELLGGTITVESEPGGGTTVTLTL 105
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
186-358 4.34e-10

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 59.15  E-value: 4.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 186 GYIHTRMSPV---EVARNAVDDARSICSRQYGS------APDVHIYGDPDftfpyvpaHLHLMVFELVKNSLRaveerYM 256
Cdd:COG2205   82 GKLSLELEPVdlaELLEEAVEELRPLAEEKGIRleldlpPELPLVYADPE--------LLEQVLANLLDNAIK-----YS 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 257 NSDkdpPPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTARNPldehadlgvgdnvTMAGYGYGLPISRLYAR 336
Cdd:COG2205  149 PPG---GTITISARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSR-------------GEGGTGLGLAIVKRIVE 212

                        170       180
                 ....*....|....*....|..
gi 357450327 337 YFGGDLQIISMENYGTDAYLHL 358
Cdd:COG2205  213 AHGGTIWVESEPGGGTTFTVTL 234
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 268-352 1.90e-04

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 43.39  E-value: 1.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 268 IVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTARNPLDEHAdlgvgdnvtmAGYGYGLPISRLYARYFGGDLQIISM 347
Cdd:PRK11091 423 VRYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGGKPA----------TGTGIGLAVSKRLAQAMGGDITVTSE 492


                 ....*
gi 357450327 348 ENYGT 352
Cdd:PRK11091 493 EGKGS 497
 
Name Accession Description Interval E-value
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 193-359 6.29e-78

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 236.85  E-value: 6.29e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 193 SPVEVARNAVDDARSICSRQYGSAPDVHIYGDPDFTFPYVPAHLHLMVFELVKNSLRAVEERYMNSDKDPPPIRIIVADG 272
Cdd:cd16929    1 SPKKVVEDASEEARVLCDDYYLSSPELEIEGDPSIRFPYVPSHLYYILFELLKNAMRATVESHGDDSDDLPPIKVTVAKG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 273 LEDVTIKISDEGGGIPRSGLRKIFTYLYSTARNPL--DEHADLGVGDNVTMAGYGYGLPISRLYARYFGGDLQIISMENY 350
Cdd:cd16929   81 DEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPSldDFSDLISGTQPSPLAGFGYGLPMSRLYAEYFGGDLDLQSMEGY 160


                 ....*....
gi 357450327 351 GTDAYLHLS 359
Cdd:cd16929  161 GTDVYIYLK 169
BCDHK_Adom3 pfam10436
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ...
 28-189 3.40e-69

Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.


Pssm-ID: 463093  Cd Length: 158  Bit Score: 214.29  E-value: 3.40e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327   28 GVSLRYMMDFGSKPTSKNLLISAQFLHKELAIRIARRAVELERLPCDLSQKPAVLKVRDWYLDSFRDIRSFSEIKnMNDE 107
Cdd:pfam10436   1 PLSLRQLLDFGRSLSEEKLLKSANFLREELPVRLAHRIRELQNLPYILVSNPSISKVYEWYLQSFEELLSFPPPI-LEDN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327  108 KEFTEVIKAIKVRHNNVVPTMALGVQQLKKDVDPKiinqdfvEIHQFLDRFYMSRIGIRMLIGQHVELH----SPNPPPH 183
Cdd:pfam10436  80 EKFTELLEEILDRHNDVVPTLAQGVLELKKYLSPE-------EIQSFLDRFLRSRIGIRLLAEQHIALTeqsnNPSHPPD 152


                  ....*.
gi 357450327  184 VVGYIH 189
Cdd:pfam10436 153 YVGIID 158
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 233-358 3.49e-18

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 79.23  E-value: 3.49e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327   233 PAHLHLMVFELVKNSLRAVEERymnsdkdpPPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTArnpldehad 312
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTPEG--------GRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTD--------- 65

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 357450327   313 lgvGDNVTMAGYGYGLPISRLYARYFGGDLQIISMENYGTDAYLHL 358
Cdd:smart00387  66 ---KRSRKIGGTGLGLSIVKKLVELHGGEISVESEPGGGTTFTITL 108
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 232-358 1.66e-16

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 74.71  E-value: 1.66e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327  232 VPAHLHLMVFELVKNSLRAVEErymnsdkdPPPIRIIVADGlEDVTIKISDEGGGIPRSGLRKIFTYLYStarnpldeha 311
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAK--------AGEITVTLSEG-GELTLTVEDNGIGIPPEDLPRIFEPFST---------- 62

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 357450327  312 dlgvGDNVTMAGYGYGLPISRLYARYFGGDLQIISMENYGTDAYLHL 358
Cdd:pfam02518  63 ----ADKRGGGGTGLGLSIVRKLVELLGGTITVESEPGGGTTVTLTL 105
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
186-358 4.34e-10

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 59.15  E-value: 4.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 186 GYIHTRMSPV---EVARNAVDDARSICSRQYGS------APDVHIYGDPDftfpyvpaHLHLMVFELVKNSLRaveerYM 256
Cdd:COG2205   82 GKLSLELEPVdlaELLEEAVEELRPLAEEKGIRleldlpPELPLVYADPE--------LLEQVLANLLDNAIK-----YS 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 257 NSDkdpPPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTARNPldehadlgvgdnvTMAGYGYGLPISRLYAR 336
Cdd:COG2205  149 PPG---GTITISARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSR-------------GEGGTGLGLAIVKRIVE 212

                        170       180
                 ....*....|....*....|..
gi 357450327 337 YFGGDLQIISMENYGTDAYLHL 358
Cdd:COG2205  213 AHGGTIWVESEPGGGTTFTVTL 234
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
189-358 6.10e-10

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 59.92  E-value: 6.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 189 HTRMSPVEVARNAVDDARSICSRQ------YGSAPDVHIYGDPDftfpyvpaHLHLMVFELVKNSLRaveerYMNSDKdp 262
Cdd:COG0642  179 PEPVDLAELLEEVVELFRPLAEEKgielelDLPDDLPTVRGDPD--------RLRQVLLNLLSNAIK-----YTPEGG-- 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 263 pPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTARNPLDEhadlgvgdnvtmaGYGYGLPISRLYARYFGGDL 342
Cdd:COG0642  244 -TVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGG-------------GTGLGLAIVKRIVELHGGTI 309

                        170
                 ....*....|....*.
gi 357450327 343 QIISMENYGTDAYLHL 358
Cdd:COG0642  310 EVESEPGKGTTFTVTL 325
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 191-352 3.11e-08

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 54.80  E-value: 3.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 191 RMSPVEVARnAVDDARSICSRQYGSAP-DVHIYGDPDFtfPYV---PAHLHLMVFELVKNSLRAVEERymnsdkDPPPIR 266
Cdd:COG4191  211 EREPVDLNE-LIDEALELLRPRLKARGiEVELDLPPDL--PPVlgdPGQLEQVLLNLLINAIDAMEEG------EGGRIT 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 267 IIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTARnpldehadlgVGDnvtmaGYGYGLPISRLYARYFGGDLQIIS 346
Cdd:COG4191  282 ISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKP----------VGK-----GTGLGLSISYGIVEKHGGRIEVES 346


                 ....*.
gi 357450327 347 MENYGT 352
Cdd:COG4191  347 EPGGGT 352
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 191-365 1.31e-07

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 53.04  E-value: 1.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 191 RMSPVEVARnAVDDARSICSRQYgSAPDVHIYGDPDFTFPYV---PAHLHLMVFELVKNSLRAVEERymnsdkdpPPIRI 267
Cdd:COG5000  272 QLEPVDLNE-LLREVLALYEPAL-KEKDIRLELDLDPDLPEVladRDQLEQVLINLLKNAIEAIEEG--------GEIEV 341

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 268 IVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTARNpldehadlgvgdnvtmaGYGYGLPISRLYARYFGGDLQIISM 347
Cdd:COG5000  342 STRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPK-----------------GTGLGLAIVKKIVEEHGGTIELESR 404

                        170
                 ....*....|....*...
gi 357450327 348 ENYGTDAYLHLSRLGDSQ 365
Cdd:COG5000  405 PGGGTTFTIRLPLAEEAE 422
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 233-352 1.37e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 49.34  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 233 PAHLHLMVFELVKNSLRAVEERymnsdkdpPPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTARnpldehad 312
Cdd:cd16943    1 PSQLNQVLLNLLVNAAQAMEGR--------GRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKP-------- 64

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 357450327 313 lgVGDnvtmaGYGYGLPISRLYARYFGGDLQIISMENYGT 352
Cdd:cd16943   65 --VGE-----GTGLGLSLSYRIIQKHGGTIRVASVPGGGT 97
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 243-352 6.27e-06

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 47.54  E-value: 6.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 243 LVKNSLRAVEErymnSDKDPPPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTARNpldehadlgvgdnvtmA 322
Cdd:COG3290  289 LLDNAIEAVEK----LPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKLG----------------E 348

                         90       100       110
                 ....*....|....*....|....*....|
gi 357450327 323 GYGYGLPISRLYARYFGGDLQIISMENYGT 352
Cdd:COG3290  349 GRGLGLALVKQIVEKYGGTIEVESEEGEGT 378
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 218-358 9.46e-06

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 47.28  E-value: 9.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 218 DVHIYGDPDFTFPYV---PAHLHLMVFELVKNSLRAveeryMNSDKDpppirIIVADGLED---VTIKISDEGGGIPRSG 291
Cdd:COG5809  359 NVQIELELEDDIPDIlgdENQLKQVFINLLKNAIEA-----MPEGGN-----ITIETKAEDddkVVISVTDEGCGIPEER 428

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 357450327 292 LRKIFTYLYSTARNpldehadlgvgdnvtmaGYGYGLPISRLYARYFGGDLQIISMENYGTDAYLHL 358
Cdd:COG5809  429 LKKLGEPFYTTKEK-----------------GTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITL 478
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 243-352 6.36e-05

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 44.72  E-value: 6.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 243 LVKNSLRAVEerymnsdkDPPPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTARNpldehadlgvgdnvtma 322
Cdd:COG5805  403 LIKNAIEAMP--------NGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEK----------------- 457

                         90       100       110
                 ....*....|....*....|....*....|
gi 357450327 323 GYGYGLPISRLYARYFGGDLQIISMENYGT 352
Cdd:COG5805  458 GTGLGLMVSYKIIENHNGTIDIDSKVGKGT 487
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
190-358 7.51e-05

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 44.54  E-value: 7.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 190 TRMSPVEVARNAVDDARSICSRQ------YGSAPDVHIYGDPDftfpyvpaHLHLMVFELVKNSLRaveerYMNSDKdpp 263
Cdd:COG5002  238 EPVDLAELLEEVVEELRPLAEEKgielelDLPEDPLLVLGDPD--------RLEQVLTNLLDNAIK-----YTPEGG--- 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 264 PIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLY--STARNPldehadlgvgdnvTMAGYGYGLPISRLYARYFGGD 341
Cdd:COG5002  302 TITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYrvDKSRSR-------------ETGGTGLGLAIVKHIVEAHGGR 368

                        170
                 ....*....|....*..
gi 357450327 342 LQIISMENYGTDAYLHL 358
Cdd:COG5002  369 IWVESEPGKGTTFTITL 385
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 265-344 1.43e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 40.52  E-value: 1.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 265 IRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTARnpldehadlgvgDNVTMAGYGYGLPISRLYARYFGGDLQI 344
Cdd:cd16945   26 IALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPR------------PHSGQKSTGLGLAFVQEVAQLHGGRITL 93
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 240-351 1.69e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 40.52  E-value: 1.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 240 VFELVKNSLRAVEERymnsdkDPPPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTARnpldehadlgVGDnv 319
Cdd:cd16976    5 LMNLLQNALDAMGKV------ENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKP----------VGK-- 66

                         90       100       110
                 ....*....|....*....|....*....|..
gi 357450327 320 tmaGYGYGLPISRLYARYFGGDLQIISMENYG 351
Cdd:cd16976   67 ---GTGLGLSISYGIVEEHGGRLSVANEEGAG 95
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 268-352 1.90e-04

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 43.39  E-value: 1.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 268 IVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTARNPLDEHAdlgvgdnvtmAGYGYGLPISRLYARYFGGDLQIISM 347
Cdd:PRK11091 423 VRYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGGKPA----------TGTGIGLAVSKRLAQAMGGDITVTSE 492


                 ....*
gi 357450327 348 ENYGT 352
Cdd:PRK11091 493 EGKGS 497
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 239-352 1.96e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 40.35  E-value: 1.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 239 MVFELVKNSLRAVeerymnSDKDPPPIRIIVADGLE--DVTIKISDEGGGIPRSGLRKIFTYLYSTarNPLDEHadlgvg 316
Cdd:cd16915    4 IVGNLIDNALDAL------AATGAPNKQVEVFLRDEgdDLVIEVRDTGPGIAPELRDKVFERGVST--KGQGER------ 69

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 357450327 317 dnvtmagyGYGLPISRLYARYFGGDLQIISMENYGT 352
Cdd:cd16915   70 --------GIGLALVRQSVERLGGSITVESEPGGGT 97
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 215-362 3.29e-04

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 42.52  E-value: 3.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 215 SAPDVHIYGDPDFtfpyvpahLHLMVFELVKNSLraveerymnsDKDPPPIRIIVADGLED--VTIKISDEGGGIPRSGL 292
Cdd:PRK11100 356 RPDDARVLGDPFL--------LRQALGNLLDNAI----------DFSPEGGTITLSAEVDGeqVALSVEDQGPGIPDYAL 417

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 293 RKIFTYLYSTARnPldehadlGVGDNVTmagyGYGLPISRLYARYFGGDLQIISMENYGTDAYLHLSRLG 362
Cdd:PRK11100 418 PRIFERFYSLPR-P-------ANGRKST----GLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRHF 475
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 215-339 1.09e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 38.16  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 215 SAPDVHIYGDPDFtfpyvpahLHLMVFELVKNSLRaveerYMNSDKDpppIRIIVADGLEDVtIKISDEGGGIPRSGLRK 294
Cdd:cd16940    1 SAADIQVQGDALL--------LFLLLRNLVDNAVR-----YSPQGSR---VEIKLSADDGAV-IRVEDNGPGIDEEELEA 63

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 357450327 295 IFTYLYSTarnpldehadlgvgDNVTMAGYGYGLPI-SRLYARYFG 339
Cdd:cd16940   64 LFERFYRS--------------DGQNYGGSGLGLSIvKRIVELHGG 95
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 240-352 1.93e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 37.38  E-value: 1.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 240 VFELVKNSLRAVEEryMNSDKDPPPIRIIVADgLEDVTIKISDEGGGIPRSGLRKIFTYLYSTARNpldehadlgvgdnv 319
Cdd:cd16920    5 LINLVRNGIEAMSE--GGCERRELTIRTSPAD-DRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSE-------------- 67

                         90       100       110
                 ....*....|....*....|....*....|...
gi 357450327 320 tmaGYGYGLPISRLYARYFGGDLQIISMENYGT 352
Cdd:cd16920   68 ---GLGMGLSICRSIIEAHGGRLSVESPAGGGA 97
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
165-358 3.35e-03

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 39.06  E-value: 3.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 165 IRMLIGQHVELHSPNPPphvvgyihtRMSPVEVARnAVDDARSICSRQYGS--------APDV-HIYGDPDftfpyvpaH 235
Cdd:COG3852  183 LNNLVDRLLSFSRPRPP---------EREPVNLHE-VLERVLELLRAEAPKnirivrdyDPSLpEVLGDPD--------Q 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 236 LHLMVFELVKNSLRAVEE--------RYMNSDKDPPpiriiVADGLEdVTIKISDEGGGIPRSGLRKIFTYLYSTARNpl 307
Cdd:COG3852  245 LIQVLLNLVRNAAEAMPEggtitirtRVERQVTLGG-----LRPRLY-VRIEVIDNGPGIPEEILDRIFEPFFTTKEK-- 316

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 357450327 308 dehadlgvgdnvtmaGYGYGLPISRLYARYFGGDLQIISMENYGTDAYLHL 358
Cdd:COG3852  317 ---------------GTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYL 352
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 243-349 3.62e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 36.75  E-value: 3.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 243 LVKNSLRAVEERymnsDKDPPPIRIIV-ADGLEDVTIKISDEGGGIPRSGLRKIFTYlYSTARNpldehadlgvgdnvtm 321
Cdd:cd16944   12 ILKNAAEAIEGR----PSDVGEVRIRVeADQDGRIVLIVCDNGKGFPREMRHRATEP-YVTTRP---------------- 70

                         90       100
                 ....*....|....*....|....*...
gi 357450327 322 AGYGYGLPISRLYARYFGGdlqIISMEN 349
Cdd:cd16944   71 KGTGLGLAIVKKIMEEHGG---RISLSN 95
PRK15347 PRK15347
two component system sensor kinase;
278-369 3.89e-03

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 39.24  E-value: 3.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 278 IKISDEGGGIPRSGLRKIFTYLYSTarnplDEHadlgvgdnvtMAGYGYGLPISRLYARYFGGDLQIISMENYGTDAYLH 357
Cdd:PRK15347 547 FTVEDTGCGIDIQQQQQIFTPFYQA-----DTH----------SQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLV 611

                         90
                 ....*....|..
gi 357450327 358 LSrLGDSQEPLP 369
Cdd:PRK15347 612 LP-LNEYAPPEP 622
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 220-346 5.39e-03

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 38.90  E-value: 5.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 220 HIYGDPDftfpyVPA---HLHLMVFELVKNSLRAVEErymnsdkdPPPIRIIVADGLEDVTIKISDEGGGIPRSGlrKIF 296
Cdd:COG4192  530 HIPDDLM-----VQGdqvLLEQVLVNLLVNALDAVAT--------QPQISVDLLSNAENLRVAISDNGNGWPLVD--KLF 594

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 357450327 297 TYLYSTARnpldehadlgvgdnvtmAGYGYGLPISRLYARYFGGDLQIIS 346
Cdd:COG4192  595 TPFTTTKE-----------------VGLGLGLSICRSIMQQFGGDLYLAS 627
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 240-346 5.52e-03

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 36.93  E-value: 5.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327  240 VFELVKNSLRAVEERymnsdkdpppIRIIVADGLEDVT-IKISDEGGGIPRSGLRKIFTYLYSTARNPLDeHADLGVgdn 318
Cdd:pfam13589   5 LAELIDNSIDADATN----------IKIEVNKNRGGGTeIVIEDDGHGMSPEELINALRLATSAKEAKRG-STDLGR--- 70

                          90       100
                  ....*....|....*....|....*...
gi 357450327  319 vtmagYGYGLpisRLYARYFGGDLQIIS 346
Cdd:pfam13589  71 -----YGIGL---KLASLSLGAKLTVTS 90
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 276-358 6.42e-03

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 36.20  E-value: 6.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357450327 276 VTIKISDEGGGIPRSGLRKIFTYLYSTArnpldehadlGVGdnvtmAGYGYGLPISRLYARYFGGDLQIISMENYGTDAY 355
Cdd:cd16919   48 VCLEVSDTGSGMPAEVLRRAFEPFFTTK----------EVG-----KGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVR 112


                 ...
gi 357450327 356 LHL 358
Cdd:cd16919  113 IYL 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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