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Conserved domains on  [gi|357127130|ref|XP_003565238|]
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WD repeat-containing protein 53 [Brachypodium distachyon]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12822048)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-331 4.03e-21

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.82  E-value: 4.03e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130  12 STERKPRRLRGHKkGAVTCcVASSARPGVVVSSGEDGCLCWFDLRTKDVLLTIEATNKAISSVCFKAGNEDFVYVSAGNE 91
Cdd:COG2319  108 ATGLLLRTLTGHT-GAVRS-VAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130  92 ILSFDVRMGsqsKPLETYNYNREEINQIAVSSKG-FLAAADDSGDVKI--VNTmQKCLykRLREAHTSICSSVQFIPWRP 168
Cdd:COG2319  186 VRLWDLATG---KLLRTLTGHTGAVRSVAFSPDGkLLASGSADGTVRLwdLAT-GKLL--RTLTGHSGSVRSVAFSPDGR 259

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130 169 WtAITGGLDSKLAVWDFSKGRTLFSIDYGSpemqnrsssasagqclnpAFIHSVAVSEEGglyKVCAVARGDGAVDVVDL 248
Cdd:COG2319  260 L-LASGSADGTVRLWDLATGELLRTLTGHS------------------GGVNSVAFSPDG---KLLASGSDDGTVRLWDL 317

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130 249 EYELAPAKSKGPSRAGGS-AMSSKGTDLGNGSSNQS----QQKRILLDYTMGGHTAAVSCVAFSAfgeKGKFLVSGGNDA 323
Cdd:COG2319  318 ATGKLLRTLTGHTGAVRSvAFSPDGKTLASGSDDGTvrlwDLATGELLRTLTGHTGAVTSVAFSP---DGRTLASGSADG 394


                 ....*...
gi 357127130 324 SVKLWDWS 331
Cdd:COG2319  395 TVRLWDLA 402
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 296-380 1.62e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 46.17  E-value: 1.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130 296 GHTAAVSCVAFSAfgeKGKFLVSGGNDASVKLWDWSKGFSSETNSNSELvldidvkkKVNWlCTAPTDSDNLIVCDTSKV 375
Cdd:cd00200    7 GHTGGVTCVAFSP---DGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--------PVRD-VAASADGTYLASGSSDKT 74


                 ....*
gi 357127130 376 VKVYN 380
Cdd:cd00200   75 IRLWD 79
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-331 4.03e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.82  E-value: 4.03e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130  12 STERKPRRLRGHKkGAVTCcVASSARPGVVVSSGEDGCLCWFDLRTKDVLLTIEATNKAISSVCFKAGNEDFVYVSAGNE 91
Cdd:COG2319  108 ATGLLLRTLTGHT-GAVRS-VAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130  92 ILSFDVRMGsqsKPLETYNYNREEINQIAVSSKG-FLAAADDSGDVKI--VNTmQKCLykRLREAHTSICSSVQFIPWRP 168
Cdd:COG2319  186 VRLWDLATG---KLLRTLTGHTGAVRSVAFSPDGkLLASGSADGTVRLwdLAT-GKLL--RTLTGHSGSVRSVAFSPDGR 259

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130 169 WtAITGGLDSKLAVWDFSKGRTLFSIDYGSpemqnrsssasagqclnpAFIHSVAVSEEGglyKVCAVARGDGAVDVVDL 248
Cdd:COG2319  260 L-LASGSADGTVRLWDLATGELLRTLTGHS------------------GGVNSVAFSPDG---KLLASGSDDGTVRLWDL 317

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130 249 EYELAPAKSKGPSRAGGS-AMSSKGTDLGNGSSNQS----QQKRILLDYTMGGHTAAVSCVAFSAfgeKGKFLVSGGNDA 323
Cdd:COG2319  318 ATGKLLRTLTGHTGAVRSvAFSPDGKTLASGSDDGTvrlwDLATGELLRTLTGHTGAVTSVAFSP---DGRTLASGSADG 394


                 ....*...
gi 357127130 324 SVKLWDWS 331
Cdd:COG2319  395 TVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-194 6.66e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.38  E-value: 6.66e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130  12 STERKPRRLRGHKKgAVTCCVASSARPgVVVSSGEDGCLCWFDLRTKDVLLTIEATNKAISSVCFkAGNEDFVYVSAGNE 91
Cdd:cd00200   81 ETGECVRTLTGHTS-YVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF-SPDGTFVASSSQDG 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130  92 ILSF-DVRMGsqsKPLETYNYNREEINQIAVSSKG--FLAAADDsGDVKIVNT-MQKCLYkrLREAHTSICSSVQFIPWR 167
Cdd:cd00200  158 TIKLwDLRTG---KCVATLTGHTGEVNSVAFSPDGekLLSSSSD-GTIKLWDLsTGKCLG--TLRGHENGVNSVAFSPDG 231

                        170       180
                 ....*....|....*....|....*..
gi 357127130 168 PWtAITGGLDSKLAVWDFSKGRTLFSI 194
Cdd:cd00200  232 YL-LASGSEDGTIRVWDLRTGECVQTL 257
WD40 pfam00400
WD domain, G-beta repeat;
292-329 3.25e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 3.25e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 357127130  292 YTMGGHTAAVSCVAFSAfgeKGKFLVSGGNDASVKLWD 329
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSP---DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 292-329 3.64e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 3.64e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 357127130   292 YTMGGHTAAVSCVAFSafgEKGKFLVSGGNDASVKLWD 329
Cdd:smart00320   6 KTLKGHTGPVTSVAFS---PDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 296-380 1.62e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.17  E-value: 1.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130 296 GHTAAVSCVAFSAfgeKGKFLVSGGNDASVKLWDWSKGFSSETNSNSELvldidvkkKVNWlCTAPTDSDNLIVCDTSKV 375
Cdd:cd00200    7 GHTGGVTCVAFSP---DGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--------PVRD-VAASADGTYLASGSSDKT 74


                 ....*
gi 357127130 376 VKVYN 380
Cdd:cd00200   75 IRLWD 79
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-331 4.03e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.82  E-value: 4.03e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130  12 STERKPRRLRGHKkGAVTCcVASSARPGVVVSSGEDGCLCWFDLRTKDVLLTIEATNKAISSVCFKAGNEDFVYVSAGNE 91
Cdd:COG2319  108 ATGLLLRTLTGHT-GAVRS-VAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130  92 ILSFDVRMGsqsKPLETYNYNREEINQIAVSSKG-FLAAADDSGDVKI--VNTmQKCLykRLREAHTSICSSVQFIPWRP 168
Cdd:COG2319  186 VRLWDLATG---KLLRTLTGHTGAVRSVAFSPDGkLLASGSADGTVRLwdLAT-GKLL--RTLTGHSGSVRSVAFSPDGR 259

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130 169 WtAITGGLDSKLAVWDFSKGRTLFSIDYGSpemqnrsssasagqclnpAFIHSVAVSEEGglyKVCAVARGDGAVDVVDL 248
Cdd:COG2319  260 L-LASGSADGTVRLWDLATGELLRTLTGHS------------------GGVNSVAFSPDG---KLLASGSDDGTVRLWDL 317

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130 249 EYELAPAKSKGPSRAGGS-AMSSKGTDLGNGSSNQS----QQKRILLDYTMGGHTAAVSCVAFSAfgeKGKFLVSGGNDA 323
Cdd:COG2319  318 ATGKLLRTLTGHTGAVRSvAFSPDGKTLASGSDDGTvrlwDLATGELLRTLTGHTGAVTSVAFSP---DGRTLASGSADG 394


                 ....*...
gi 357127130 324 SVKLWDWS 331
Cdd:COG2319  395 TVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
2-333 9.06e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.05  E-value: 9.06e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130   2 SETGAAAGASSTERKPRRLRGHKKGAVTccVASSARPGVVVSSGEDGCLCWFDLRTKDVLLTIEATNKAISSVCFKAGNE 81
Cdd:COG2319   56 GDLTLLLLDAAAGALLATLLGHTAAVLS--VAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGK 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130  82 DFVYVSAGNEILSFDVRMGsqsKPLETYNYNREEINQIAVSSKG-FLAAADDSGDVKIVNTMQKCLYKRLReAHTSICSS 160
Cdd:COG2319  134 TLASGSADGTVRLWDLATG---KLLRTLTGHSGAVTSVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRS 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130 161 VQFIPWRPWtAITGGLDSKLAVWDFSKGRTLFSIDYGSPEmqnrsssasagqclnpafIHSVAVSEEGglyKVCAVARGD 240
Cdd:COG2319  210 VAFSPDGKL-LASGSADGTVRLWDLATGKLLRTLTGHSGS------------------VRSVAFSPDG---RLLASGSAD 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130 241 GAVDVVDLEYELAPAKSKGPSRAGGS-AMSSKGTDLGNGSSNQS------QQKRILldYTMGGHTAAVSCVAFSAfgeKG 313
Cdd:COG2319  268 GTVRLWDLATGELLRTLTGHSGGVNSvAFSPDGKLLASGSDDGTvrlwdlATGKLL--RTLTGHTGAVRSVAFSP---DG 342

                        330       340
                 ....*....|....*....|
gi 357127130 314 KFLVSGGNDASVKLWDWSKG 333
Cdd:COG2319  343 KTLASGSDDGTVRLWDLATG 362
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-194 6.66e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.38  E-value: 6.66e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130  12 STERKPRRLRGHKKgAVTCCVASSARPgVVVSSGEDGCLCWFDLRTKDVLLTIEATNKAISSVCFkAGNEDFVYVSAGNE 91
Cdd:cd00200   81 ETGECVRTLTGHTS-YVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF-SPDGTFVASSSQDG 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130  92 ILSF-DVRMGsqsKPLETYNYNREEINQIAVSSKG--FLAAADDsGDVKIVNT-MQKCLYkrLREAHTSICSSVQFIPWR 167
Cdd:cd00200  158 TIKLwDLRTG---KCVATLTGHTGEVNSVAFSPDGekLLSSSSD-GTIKLWDLsTGKCLG--TLRGHENGVNSVAFSPDG 231

                        170       180
                 ....*....|....*....|....*..
gi 357127130 168 PWtAITGGLDSKLAVWDFSKGRTLFSI 194
Cdd:cd00200  232 YL-LASGSEDGTIRVWDLRTGECVQTL 257
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-329 8.62e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.99  E-value: 8.62e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130  12 STERKPRRLRGHKkGAVTCCVASSARPgVVVSSGEDGCLCWFDLRTKDVLLTIEATNKAISSVCFKAGNEdfvYVSAG-- 89
Cdd:cd00200   39 ETGELLRTLKGHT-GPVRDVAASADGT-YLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGR---ILSSSsr 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130  90 -NEILSFDVRMGSQSKpleTYNYNREEINQIAVS-SKGFLAAADDSGDVKIVNtMQKCLYKRLREAHTSICSSVQFIPwR 167
Cdd:cd00200  114 dKTIKVWDVETGKCLT---TLRGHTDWVNSVAFSpDGTFVASSSQDGTIKLWD-LRTGKCVATLTGHTGEVNSVAFSP-D 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130 168 PWTAITGGLDSKLAVWDFSKGRTLFSIDYgspemqnrsssasagqclNPAFIHSVAVSEEGGLykvCAVARGDGAVDVVD 247
Cdd:cd00200  189 GEKLLSSSSDGTIKLWDLSTGKCLGTLRG------------------HENGVNSVAFSPDGYL---LASGSEDGTIRVWD 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130 248 LEyelapakskgpsraggsamsskgtdlgNGSsnqsqqkrilLDYTMGGHTAAVSCVAFSafgEKGKFLVSGGNDASVKL 327
Cdd:cd00200  248 LR---------------------------TGE----------CVQTLSGHTNSVTSLAWS---PDGKRLASGSADGTIRI 287


                 ..
gi 357127130 328 WD 329
Cdd:cd00200  288 WD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 18-363 6.19e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.52  E-value: 6.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130  18 RRLRGHKKGAvtCCVASSARPGVVVSSGEDGCLCWFDLRTKDVLLTIEATNKAISSVcfkagnedfVYVSAGNEILSfdv 97
Cdd:cd00200    3 RTLKGHTGGV--TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDV---------AASADGTYLAS--- 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130  98 rmgsqskpletynynreeinqiavsskgflaAADDsGDVKIVNTMQKCLYKRLrEAHTSICSSVQFIPWRPWtAITGGLD 177
Cdd:cd00200   69 -------------------------------GSSD-KTIRLWDLETGECVRTL-TGHTSYVSSVAFSPDGRI-LSSSSRD 114

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130 178 SKLAVWDFSKGRTLFSIDYgspemqnrsssasagqclNPAFIHSVAVSEEGGLYkvcAVARGDGAVDVVDLEYELAPAKS 257
Cdd:cd00200  115 KTIKVWDVETGKCLTTLRG------------------HTDWVNSVAFSPDGTFV---ASSSQDGTIKLWDLRTGKCVATL 173

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130 258 KGPSRAG-GSAMSSKGTDLGNGSSNQS-----QQKRILLdYTMGGHTAAVSCVAFSafgEKGKFLVSGGNDASVKLWDWS 331
Cdd:cd00200  174 TGHTGEVnSVAFSPDGEKLLSSSSDGTiklwdLSTGKCL-GTLRGHENGVNSVAFS---PDGYLLASGSEDGTIRVWDLR 249

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 357127130 332 KG-----FSSETNSnselVLDIDVKKKVNWLCTAPTD 363
Cdd:cd00200  250 TGecvqtLSGHTNS----VTSLAWSPDGKRLASGSAD 282
WD40 pfam00400
WD domain, G-beta repeat;
292-329 3.25e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 3.25e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 357127130  292 YTMGGHTAAVSCVAFSAfgeKGKFLVSGGNDASVKLWD 329
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSP---DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 292-329 3.64e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 3.64e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 357127130   292 YTMGGHTAAVSCVAFSafgEKGKFLVSGGNDASVKLWD 329
Cdd:smart00320   6 KTLKGHTGPVTSVAFS---PDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 296-380 1.62e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.17  E-value: 1.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130 296 GHTAAVSCVAFSAfgeKGKFLVSGGNDASVKLWDWSKGFSSETNSNSELvldidvkkKVNWlCTAPTDSDNLIVCDTSKV 375
Cdd:cd00200    7 GHTGGVTCVAFSP---DGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--------PVRD-VAASADGTYLASGSSDKT 74


                 ....*
gi 357127130 376 VKVYN 380
Cdd:cd00200   75 IRLWD 79
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 290-382 1.90e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.79  E-value: 1.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357127130 290 LDYTMGGHTAAVSCVAFSAFGekgKFLVSGGNDASVKLWDWSKGFSSET-NSNSELVLDIDVKKKVNWLCTAPTDsdnli 368
Cdd:cd00200   43 LLRTLKGHTGPVRDVAASADG---TYLASGSSDKTIRLWDLETGECVRTlTGHTSYVSSVAFSPDGRILSSSSRD----- 114

                         90
                 ....*....|....
gi 357127130 369 vcdtsKVVKVYNFP 382
Cdd:cd00200  115 -----KTIKVWDVE 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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