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Conserved domains on  [gi|357126488|ref|XP_003564919|]
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uncharacterized protein LOC100840198 [Brachypodium distachyon]

Protein Classification

WW domain-containing protein( domain architecture ID 10449603)

WW domain-containing protein; the WW domain mediates protein-protein interaction via proline-rich motifs, such as PPxY

CATH:  2.20.70.10
Gene Ontology:  GO:0005515
PubMed:  22201747|9029943|7641887

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 290-320 9.61e-10

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


:

Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 53.66  E-value: 9.61e-10
                          10        20        30
                  ....*....|....*....|....*....|.
gi 357126488  290 LPPGWVEAKDPTtGASYFYNQSTGVTQWDRP 320
Cdd:pfam00397   1 LPPGWEERWDPD-GRVYYYNHETGETQWEKP 30
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 335-365 5.64e-09

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


:

Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 51.35  E-value: 5.64e-09
                          10        20        30
                  ....*....|....*....|....*....|.
gi 357126488  335 LPENWEEALDkSTGQKYYYNTKTHATQWEPP 365
Cdd:pfam00397   1 LPPGWEERWD-PDGRVYYYNHETGETQWEKP 30
PTZ00395 super family cl33180
Sec24-related protein; Provisional
 14-174 6.48e-04

Sec24-related protein; Provisional


The actual alignment was detected with superfamily member PTZ00395:

Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 42.75  E-value: 6.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126488   14 GTWQPPPSNHPSQFQPSPRPHAYPTPYDTRPNGG---NNQNTANVFYATQPFHPSP------HPHAYPAPYDTRPNN--- 81
Cdd:PTZ00395  418 GNSNPGYNNAPNSNTPYNNPPNSNTPYSNPPNSNppySNLPYSNTPYSNAPLSNAPpssakdHHSAYHAAYQHRAANqpa 497

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126488   82 ----GSNQDTSNLFYATQPNTPLLPAQSTPNAPTDPGNwqahqTAHEVANHNGSAA---NIESAVQEAVLHEQDIETQQV 154
Cdd:PTZ00395  498 anlpTANQPAANNFHGAAGNSVGNPFASRPFGSAPYGG-----NAATTADPNGIAKredHPEGGTNRQKYEQSDEESVES 572

                         170       180
                  ....*....|....*....|
gi 357126488  155 IQNQRQANATSEPAEYGEDM 174
Cdd:PTZ00395  573 SSSENSSENENEVTDKGEEI 592
 
Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 290-320 9.61e-10

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 53.66  E-value: 9.61e-10
                          10        20        30
                  ....*....|....*....|....*....|.
gi 357126488  290 LPPGWVEAKDPTtGASYFYNQSTGVTQWDRP 320
Cdd:pfam00397   1 LPPGWEERWDPD-GRVYYYNHETGETQWEKP 30
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 335-365 5.64e-09

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 51.35  E-value: 5.64e-09
                          10        20        30
                  ....*....|....*....|....*....|.
gi 357126488  335 LPENWEEALDkSTGQKYYYNTKTHATQWEPP 365
Cdd:pfam00397   1 LPPGWEERWD-PDGRVYYYNHETGETQWEKP 30
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 334-367 3.13e-08

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 49.52  E-value: 3.13e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 357126488   334 SLPENWEEALDKStGQKYYYNTKTHATQWEPPTS 367
Cdd:smart00456   1 PLPPGWEERKDPD-GRPYYYNHETKETQWEKPRE 33
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 336-366 1.39e-07

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 47.52  E-value: 1.39e-07
                         10        20        30
                 ....*....|....*....|....*....|.
gi 357126488 336 PENWEEALDKStGQKYYYNTKTHATQWEPPT 366
Cdd:cd00201    1 PPGWEERWDPD-GRVYYYNHNTKETQWEDPR 30
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 290-320 2.17e-07

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 47.21  E-value: 2.17e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 357126488   290 LPPGWVEAKDPTtGASYFYNQSTGVTQWDRP 320
Cdd:smart00456   2 LPPGWEERKDPD-GRPYYYNHETKETQWEKP 31
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 291-320 5.13e-07

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 45.98  E-value: 5.13e-07
                         10        20        30
                 ....*....|....*....|....*....|
gi 357126488 291 PPGWVEAKDPTtGASYFYNQSTGVTQWDRP 320
Cdd:cd00201    1 PPGWEERWDPD-GRVYYYNHNTKETQWEDP 29
PRP40 COG5104
Splicing factor [RNA processing and modification];
294-365 4.96e-06

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 49.31  E-value: 4.96e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 357126488 294 WVEAKDPTtGASYFYNQSTGVTQWDRPGGAVNpvqhQAAPSLPEN-WEEALDKStGQKYYYNTKTHATQWEPP 365
Cdd:COG5104   17 WEELKAPD-GRIYYYNKRTGKSSWEKPKELLK----GSEEDLDVDpWKECRTAD-GKVYYYNSITRESRWKIP 83
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 14-174 6.48e-04

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 42.75  E-value: 6.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126488   14 GTWQPPPSNHPSQFQPSPRPHAYPTPYDTRPNGG---NNQNTANVFYATQPFHPSP------HPHAYPAPYDTRPNN--- 81
Cdd:PTZ00395  418 GNSNPGYNNAPNSNTPYNNPPNSNTPYSNPPNSNppySNLPYSNTPYSNAPLSNAPpssakdHHSAYHAAYQHRAANqpa 497

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126488   82 ----GSNQDTSNLFYATQPNTPLLPAQSTPNAPTDPGNwqahqTAHEVANHNGSAA---NIESAVQEAVLHEQDIETQQV 154
Cdd:PTZ00395  498 anlpTANQPAANNFHGAAGNSVGNPFASRPFGSAPYGG-----NAATTADPNGIAKredHPEGGTNRQKYEQSDEESVES 572

                         170       180
                  ....*....|....*....|
gi 357126488  155 IQNQRQANATSEPAEYGEDM 174
Cdd:PTZ00395  573 SSSENSSENENEVTDKGEEI 592
 
Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 290-320 9.61e-10

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 53.66  E-value: 9.61e-10
                          10        20        30
                  ....*....|....*....|....*....|.
gi 357126488  290 LPPGWVEAKDPTtGASYFYNQSTGVTQWDRP 320
Cdd:pfam00397   1 LPPGWEERWDPD-GRVYYYNHETGETQWEKP 30
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 335-365 5.64e-09

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 51.35  E-value: 5.64e-09
                          10        20        30
                  ....*....|....*....|....*....|.
gi 357126488  335 LPENWEEALDkSTGQKYYYNTKTHATQWEPP 365
Cdd:pfam00397   1 LPPGWEERWD-PDGRVYYYNHETGETQWEKP 30
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 334-367 3.13e-08

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 49.52  E-value: 3.13e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 357126488   334 SLPENWEEALDKStGQKYYYNTKTHATQWEPPTS 367
Cdd:smart00456   1 PLPPGWEERKDPD-GRPYYYNHETKETQWEKPRE 33
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 336-366 1.39e-07

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 47.52  E-value: 1.39e-07
                         10        20        30
                 ....*....|....*....|....*....|.
gi 357126488 336 PENWEEALDKStGQKYYYNTKTHATQWEPPT 366
Cdd:cd00201    1 PPGWEERWDPD-GRVYYYNHNTKETQWEDPR 30
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 290-320 2.17e-07

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 47.21  E-value: 2.17e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 357126488   290 LPPGWVEAKDPTtGASYFYNQSTGVTQWDRP 320
Cdd:smart00456   2 LPPGWEERKDPD-GRPYYYNHETKETQWEKP 31
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 291-320 5.13e-07

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 45.98  E-value: 5.13e-07
                         10        20        30
                 ....*....|....*....|....*....|
gi 357126488 291 PPGWVEAKDPTtGASYFYNQSTGVTQWDRP 320
Cdd:cd00201    1 PPGWEERWDPD-GRVYYYNHNTKETQWEDP 29
PRP40 COG5104
Splicing factor [RNA processing and modification];
294-365 4.96e-06

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 49.31  E-value: 4.96e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 357126488 294 WVEAKDPTtGASYFYNQSTGVTQWDRPGGAVNpvqhQAAPSLPEN-WEEALDKStGQKYYYNTKTHATQWEPP 365
Cdd:COG5104   17 WEELKAPD-GRIYYYNKRTGKSSWEKPKELLK----GSEEDLDVDpWKECRTAD-GKVYYYNSITRESRWKIP 83
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 14-174 6.48e-04

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 42.75  E-value: 6.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126488   14 GTWQPPPSNHPSQFQPSPRPHAYPTPYDTRPNGG---NNQNTANVFYATQPFHPSP------HPHAYPAPYDTRPNN--- 81
Cdd:PTZ00395  418 GNSNPGYNNAPNSNTPYNNPPNSNTPYSNPPNSNppySNLPYSNTPYSNAPLSNAPpssakdHHSAYHAAYQHRAANqpa 497

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126488   82 ----GSNQDTSNLFYATQPNTPLLPAQSTPNAPTDPGNwqahqTAHEVANHNGSAA---NIESAVQEAVLHEQDIETQQV 154
Cdd:PTZ00395  498 anlpTANQPAANNFHGAAGNSVGNPFASRPFGSAPYGG-----NAATTADPNGIAKredHPEGGTNRQKYEQSDEESVES 572

                         170       180
                  ....*....|....*....|
gi 357126488  155 IQNQRQANATSEPAEYGEDM 174
Cdd:PTZ00395  573 SSSENSSENENEVTDKGEEI 592
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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