BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311  153 LGRMLTEGIHTDITINASDGSIGAHRAVLAARSPVFRSMFSHNLQEKELSTINISDMSLESCQAFLNYLY-GIIKHEEFL 231
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYtGKLISEENV 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 356566311  232 thrLALLHAADKYDISDLKDVCHESLLEDI 261
Cdd:pfam00651  81 ---DDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311  153 LGRMLTEGIHTDITINASDGSIGAHRAVLAARSPVFRSMFSHNLQEKELSTINISDMSLESCQAFLNYLY-GIIKHEEFL 231
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYtGKLISEENV 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 356566311  232 thrLALLHAADKYDISDLKDVCHESLLEDI 261
Cdd:pfam00651  81 ---DDLLAAADKLQIPSLVDKCEEFLIKSL 107

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311   164 DITINASDGSIGAHRAVLAARSPVFRSMFSHNLQEKELSTINISDMSLESCQAFLNYLYG--IIKHEEFLTHrlaLLHAA 241
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTgkLDLPEENVEE---LLELA 77

                           90       100
                   ....*....|....*....|
gi 356566311   242 DKYDISDLKDVCHESLLEDI 261
Cdd:smart00225  78 DYLQIPGLVELCEEFLLKLL 97

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311  153 LGRMLTEGIHTDITINASDGSIGAHRAVLAARSPVFRSMFSHNLQEKELSTINISDMSLESCQAFLNYLY-GIIKHEEFL 231
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYtGKLISEENV 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 356566311  232 thrLALLHAADKYDISDLKDVCHESLLEDI 261
Cdd:pfam00651  81 ---DDLLAAADKLQIPSLVDKCEEFLIKSL 107

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311   164 DITINASDGSIGAHRAVLAARSPVFRSMFSHNLQEKELSTINISDMSLESCQAFLNYLYG--IIKHEEFLTHrlaLLHAA 241
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTgkLDLPEENVEE---LLELA 77

                           90       100
                   ....*....|....*....|
gi 356566311   242 DKYDISDLKDVCHESLLEDI 261
Cdd:smart00225  78 DYLQIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311 151 ESLGRMLTEGIHTDITINASDGSIGAHRAVLAARSPVFRSMFSHNLQEKELSTINISDMSLESCQAFLNYLY-GIIKHee 229
Cdd:cd18344   12 DDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYtGKAPH-- 89

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 356566311 230 FLTHRLA--LLHAADKYDISDLKDVCHESLLEDIDTKN 265
Cdd:cd18344   90 LHSHSMAcdVLAAADKYGLEGLKVLCEDALCRNLSVEN 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311 151 ESLGRMLTEGIHTDITINASDGSIGAHRAVLAARSPVFRSMFSHNLQEKELSTINISDMSLESCQAFLNYLY-GIIKHee 229
Cdd:cd18279    7 EDLGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYtGKAPN-- 84

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 356566311 230 flTHRLA--LLHAADKYDISDLKDVCHESLLEDIDTKN 265
Cdd:cd18279   85 --LDKMAddLLAAADKYALERLKVMCEDALCSNLSVEN 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311 153 LGRMLTEGIHTDITINASDGSIGAHRAVLAARSPVFRSMFSHNLQEKELSTINISDMSLESCQAFLNYLY--GIIKHEEF 230
Cdd:cd18280    5 FGALLESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYkdELPDDVEP 84

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 356566311 231 LTHRLA---------LLHAADKYDISDLKDVChESLL 258
Cdd:cd18280   85 AGSDSSsldttmaqhLLAAADRYALERLRLLC-ESRL 120

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311 156 MLTEGIHTDITINASDGSIGAHRAVLAARSPVFRSMFSHNLQEKELSTINISDMSLESCQAFLNYLY-GIIKHEEFLtHR 234
Cdd:cd18300    3 FLNKGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYtDQAPILEDG-DC 81

                         90
                 ....*....|....*....
gi 356566311 235 LALLHAADKYDISDLKDVC 253
Cdd:cd18300   82 VGLIVLANRLCLPRLVALC 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311 153 LGRMLTEGIHTDITINASDGSIGAHRAVLAARSPVFRSMFSHNLQEKELSTINISD-MSLESCQAFLNYLYG--IIKHEE 229
Cdd:cd18254   13 LNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHDsLHPEVLELLLDFAYSsrIIINEE 92

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 356566311 230 fltHRLALLHAADKYDISDLKDVCHESLLEDIDTKNVL 267
Cdd:cd18254   93 ---NAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCL 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311 160 GIHTDITINASDGSIGAHRAVLAARSPVFRSMFSHNLQEKELSTINISDMSLESCQAFLNYLYG---IIKHEEFlthrLA 236
Cdd:cd18265   21 GTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGgglRIQEDNV----ES 96

                         90       100       110
                 ....*....|....*....|....*....|.
gi 356566311 237 LLHAADKYDISDLKDVCHESLLEDIDTKNVL 267
Cdd:cd18265   97 VLEASDLLQVSKLREACVRFLEGQLHPCNCL 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311 151 ESLGRMLTEGIHTDITINASDGSIGAHRAVLAARSPVFRSMFSHNLQEKELSTINISDMSLESCQAFLNYLYgIIKHEEF 230
Cdd:cd18342   11 DELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIY-TGKAPNL 89

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 356566311 231 LTHRLALLHAADKYDISDLKDVCHESLLEDIDTKN 265
Cdd:cd18342   90 DKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311 151 ESLGRMLTEGIHTDITINASDGSIGAHRAVLAARSPVFRSMFSHNLQEKELSTINISDMSLESCQAFLNYLY-GIIK-HE 228
Cdd:cd18287   11 EDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYtGRLTlTD 90

                         90       100
                 ....*....|....*....|...
gi 356566311 229 EFLTHRLALLHAADKYDISDLKD 251
Cdd:cd18287   91 LKEDVLLDVLGLAHQYGFEELEA 113

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 356566311 155 RMLTEGIHTDITINASDGSIGAHRAVLAARSPVFRSMFSHNL-QEKELSTINISDMSLESCQAFLNYLY 222
Cdd:cd18285    8 RLLREELHTDVTFYVGSTLFKAHKAILLARVPEFFSHIIGKLsSLEDQEPINIENLEASEFKTFLRQVY 76

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311 148 KAIESLGRMLTEGIHTDITINASDGSIGAHRAVLAARSPVFRSMFSHNLQEKELSTINISDMSLESCQAFLNYLYgiikh 227
Cdd:cd18238    1 DSFKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAY----- 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 356566311 228 eeflTHRL--------ALLHAADKYDISDLKDVCHESLLEDIDTKNVL 267
Cdd:cd18238   76 ----TGKLtltvdnvqSLLYAASLLQVEEVAKACCEFMKDHLHPSNCL 119

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311 164 DITINASDGS-IGAHRAVLAARSPVFRSMFSHNLQEKELSTINISDMSLESCQAFLNYLY-----GIIKHE--EFLTHRL 235
Cdd:cd18302    7 DVTIVSEDGKeFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYtdeasAVKESQnvEFLCNVL 86

                         90       100       110
                 ....*....|....*....|....*....|
gi 356566311 236 ALlhaADKYDISDLKDVCHESLLEDIDTKN 265
Cdd:cd18302   87 VI---ADQLLITRLKEICEVALVELLSLKN 113

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311 163 TDITINASDGSIGAHRAVLAARSPVFRSMFSHNLQEKELSTINISDMSLESCQAFLNYLY-GIIKheefLTHRLA--LLH 239
Cdd:cd18352   14 SDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYtGSVD----ITNDIAkdLLR 89

                         90       100
                 ....*....|....*....|....*..
gi 356566311 240 AADKYDISDLKDVCHESLLEDIDTKNV 266
Cdd:cd18352   90 AADQYLLEGLKRLCEYTIAQDLTLENI 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311 140 FTQQRSNAKAIESLGRMLTEGIHTDITINASDGSIGAHRAVLAARSPVFRSMFSHNLQEKELSTINISDMSLESCQAFLN 219
Cdd:cd18268    1 FKDQDLSSELLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 356566311 220 YLYG---IIKHEEFLThrlaLLHAADKYDISDLKDVCHESLLEDIDTKNVL 267
Cdd:cd18268   81 YVYTgeiLITRDNVLP----LMEAASMLQYPKLFEACSLYLQDQLTPENCL 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311 140 FTQQRSNAKAIESLGRM-LTEGIHTDITINASDGSIGAHRAVLAARSPVFRSMFSHNLQEKELSTINISDMSLESCQAFL 218
Cdd:cd18272    9 FTDRSHSSRVAQSIMDLcLEDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLV 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 356566311 219 NYLY-GIIK-HEEFLTHrlaLLHAADKYDISDLKDVCHESLLEDIDTKNVL 267
Cdd:cd18272   89 DYIYhGTVKlRVEELQE---TYEVADMYQLTALFEECSRFLARTVQVRNCL 136

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311 148 KAIESLGRMLTEGIHTDITINASDGSIGAHRAVLAARSPVFRSMFSHNLQEKELSTINISDMSLESCQAFLNYLYG--II 225
Cdd:cd18339    7 KAFKVMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTaeIE 86

                         90       100
                 ....*....|....*....|....*...
gi 356566311 226 KHEEFLThrlALLHAADKYDISDLKDVC 253
Cdd:cd18339   87 VTEENVQ---VLLPAASLLQLMDVRQNC 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311 164 DITINASDGSIGAHRAVLAARSPVFRSMFSHNLQEKELSTINISDMSLESCQAFLNYLYgiikheeflTHRLA------- 236
Cdd:cd18250   23 DVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSY---------TGRVTvtqdnve 93

                         90       100       110
                 ....*....|....*....|....*....|.
gi 356566311 237 -LLHAADKYDISDLKDVCHESLLEDIDTKNV 266
Cdd:cd18250   94 aLLRAADLFQFPSVKEACCAYLQQRLDVSNC 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311 176 AHRAVLAARSPVFRSMFSHNLQEKELSTINISDMSLESCQAFLNYLY--GIIKHEEFLTHRLALLHAADKYDISDLKDVC 253
Cdd:cd18297   26 AHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYtgGVESLDVAQDDALELLRAASFFQLDGLKRHC 105

                         90
                 ....*....|..
gi 356566311 254 HESLLEDIDTKN 265
Cdd:cd18297  106 EILLSQQIDLDN 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311 174 IGAHRAVLAARSPVFRSMFSHNLQEKELST--INISDMSLESCQAFLNYLY-GIIKHEEFLTHrlALLHAADKYDISDLK 250
Cdd:cd18245   26 IPVQKNVLAAASPYFRAKLNYNPPKDDGSTykIELEGISVEVMEEILDYIYtGQIKLSEDNIQ--DIVQAADLLLMTDLK 103

                 ....*..
gi 356566311 251 DVCHESL 257
Cdd:cd18245  104 DLCCEFL 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311 155 RMLTEGIHT--------DITINASDGSIGAHRAVLAARSPVFRSMFSHNLQEKELSTINISDMSLESCQAFLNYLY-GII 225
Cdd:cd18257    3 EQLLQGLNLlrqhhelcDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYtGTV 82

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 356566311 226 kheeFLTHRL--ALLHAADKYDISDLKDVCHESLLEDID 262
Cdd:cd18257   83 ----FISQATveSLLPAANLLQIKLVLKECCDFLESQLD 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311 150 IESLGRMLTEGIHTDITINASDGSIGAHRAVLAARSPVFRSMFSHNLQEKELSTINISDMSLESCQAFLNYLYGIIKHEE 229
Cdd:cd18276    9 LDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYSSDLHLT 88

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 356566311 230 FLTHRlALLHAADKYDISDLKDVCHESLLEDIDTKNVL 267
Cdd:cd18276   89 NSNVQ-GVATAAFFLQMEDIFSVCQKYMMDHMDASNCL 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311 143 QRSNAKAIESLGRMLTEGIHTDITINASDGSIGAHRAVLAARSPVFRSMFSHNLQEKELSTINISDMSLESCQAFLNYLY 222
Cdd:cd18246   20 KRHYHDAFVSMNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYAY 99

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 356566311 223 G--IIKHEEFLThrlALLHAADKYDISDLKDVCHESLLEDID 262
Cdd:cd18246  100 TaeIVVGEGNVQ---TLLPAASLLQLNGVRDACCKFLLSQLD 138

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311 161 IHTDITINASDGSIGAHRAVLAARSPVFRSMfshNLQEKelSTINISDMSLESCQAFLNYLYG----IIKHEEFLthrLA 236
Cdd:cd18303   17 LYSDITIKLADKSIPAHKFVLAARSEKWSNE---NLAST--NELDLSDISYEVVLALLRWLYTdeldLTLDDEFL---LE 88

                         90       100
                 ....*....|....*....|....*....
gi 356566311 237 LLHAADKYDISDLKDVCHESLLEDIDTKN 265
Cdd:cd18303   89 LMKAAKRFQLTDLVERCERALMSSVNVDN 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311 142 QQRSNAKAI-ESLGRMLTEGIHTDITINASDGSIGAHRAVLAARSPVFRSMFSHNLQEKELSTINISDMSLESCQAFLNY 220
Cdd:cd18261    7 QSKSHKDAVlAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALDF 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 356566311 221 LY-GIIKHEEFLTHRlaLLHAADKYDISDLKDVCHESLLEDIDTKNVLD 268
Cdd:cd18261   87 AYtGQILLEPGVIQD--VLAAGSHLQLLELLSLCSHYLIQELNSFNYLD 133

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356566311 153 LGRMLTegihtDITI----NASDGSIGAHRAVLAARSPVFRSMFSHNLQEKELSTINISDMSLESCQAFLNYLY--GIIK 226
Cdd:cd18248   17 LSQQLC-----DVTLkvkyQDPKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLIEFAYtaSISV 91