NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1743165224|ref|XP_003254979|]
View 

ADM [Nomascus leucogenys]

Protein Classification

adrenomedullin/calcitonin family protein( domain architecture ID 11989841)

adrenomedullin/calcitonin family protein similar to human calcitonin that causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Calc_CGRP_IAPP pfam00214
Calcitonin / CGRP / IAPP family;
1-150 1.77e-19

Calcitonin / CGRP / IAPP family;


:

Pssm-ID: 459715 [Multi-domain]  Cd Length: 130  Bit Score: 79.79  E-value: 1.77e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743165224   1 MKLISVALMYLGSLAFL----GADTARLDVASEFRKKW---NKWALSRGKRELRMSSSYPtgLADVKAGpaqtlirpQDM 73
Cdd:pfam00214   1 MGFWKFSPFLLLSILLLyqagSLQAAPFRSALESSPDPatlSEEESRLKKSKLLAALVKD--YVQMKAE--------ELE 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1743165224  74 KGASRSPEDSSpdAARIRVKRyrqsmnnfqglrsfGCRFGTCTVQKLAHQIYQFTDKDKDNVAPRSkISPQGYGRRR 150
Cdd:pfam00214  71 QEQVRETEGSS--LTHIRQKR--------------GCNLATCVTHRLAHFLSRSGNKVKDNFAPTN-VGPKGYGRRR 130
 
Name Accession Description Interval E-value
Calc_CGRP_IAPP pfam00214
Calcitonin / CGRP / IAPP family;
1-150 1.77e-19

Calcitonin / CGRP / IAPP family;


Pssm-ID: 459715 [Multi-domain]  Cd Length: 130  Bit Score: 79.79  E-value: 1.77e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743165224   1 MKLISVALMYLGSLAFL----GADTARLDVASEFRKKW---NKWALSRGKRELRMSSSYPtgLADVKAGpaqtlirpQDM 73
Cdd:pfam00214   1 MGFWKFSPFLLLSILLLyqagSLQAAPFRSALESSPDPatlSEEESRLKKSKLLAALVKD--YVQMKAE--------ELE 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1743165224  74 KGASRSPEDSSpdAARIRVKRyrqsmnnfqglrsfGCRFGTCTVQKLAHQIYQFTDKDKDNVAPRSkISPQGYGRRR 150
Cdd:pfam00214  71 QEQVRETEGSS--LTHIRQKR--------------GCNLATCVTHRLAHFLSRSGNKVKDNFAPTN-VGPKGYGRRR 130
 
Name Accession Description Interval E-value
Calc_CGRP_IAPP pfam00214
Calcitonin / CGRP / IAPP family;
1-150 1.77e-19

Calcitonin / CGRP / IAPP family;


Pssm-ID: 459715 [Multi-domain]  Cd Length: 130  Bit Score: 79.79  E-value: 1.77e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743165224   1 MKLISVALMYLGSLAFL----GADTARLDVASEFRKKW---NKWALSRGKRELRMSSSYPtgLADVKAGpaqtlirpQDM 73
Cdd:pfam00214   1 MGFWKFSPFLLLSILLLyqagSLQAAPFRSALESSPDPatlSEEESRLKKSKLLAALVKD--YVQMKAE--------ELE 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1743165224  74 KGASRSPEDSSpdAARIRVKRyrqsmnnfqglrsfGCRFGTCTVQKLAHQIYQFTDKDKDNVAPRSkISPQGYGRRR 150
Cdd:pfam00214  71 QEQVRETEGSS--LTHIRQKR--------------GCNLATCVTHRLAHFLSRSGNKVKDNFAPTN-VGPKGYGRRR 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH