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Conserved domains on  [gi|315041713|ref|XP_003170233|]
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chromatin assembly factor 1 subunit p60 [Nannizzia gypsea CBS 118893]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
6-206 1.99e-34

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.81  E-value: 1.99e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713   6 LLIAWHDDNAPIYSVHFDPHGKgRLATAGNDNNVRLWKVEsTGEErkvtyLSTLIKHTQAVNVVRFCPKGEMLASAGDDG 85
Cdd:COG2319  196 LLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDLA-TGKL-----LRTLTGHSGSVRSVAFSPDGRLLASGSADG 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  86 NVLLWvpsetqtqpgfgqealdDKETWRVKHMCRSSGAEIYDLAWSPDGVFIITGSMDNIARIYNAQTGQMVRQIAEHSH 165
Cdd:COG2319  269 TVRLW-----------------DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG 331

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 315041713 166 YVQGVAWDPLNEYVATQSSDRSVHIYALKTKDGQFTLTTHG 206
Cdd:COG2319  332 AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHT 372
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
557-700 7.20e-05

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK14971:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 614  Bit Score: 46.31  E-value: 7.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713 557 GTPSTAPA-VQSPILSSPRknSAGKASLAAIGTPAPTPTAVPARaassgPATPSSSTSKAaavvnnPTPILGTVPSVTAT 635
Cdd:PRK14971 369 ASGGRGPKqHIKPVFTQPA--AAPQPSAAAAASPSPSQSSAAAQ-----PSAPQSATQPA------GTPPTVSVDPPAAV 435

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 315041713 636 NSSQPFSTPPETPMSSHSATNSISGSVLGKRDLSTvseseKEDSHDKDEEDQTGNKTAHREPKRK 700
Cdd:PRK14971 436 PVNPPSTAPQAVRPAQFKEEKKIPVSKVSSLGPST-----LRPIQEKAEQATGNIKEAPTGTQKE 495
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 401-624 9.31e-05

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.93  E-value: 9.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  401 GTKPTRQIFLDSSSAEEAFPPlpdsvISQPAMEPPLSAPPSATSETPRPFPQSGANESDTGSQNSPIPPVFALPYRMVYA 480
Cdd:PHA03307  165 DAASSRQAALPLSSPEETARA-----PSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDS 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  481 VATQDAVLVYDTQQQTPLCvvnnlHFATFTDLSWSHDGLTLIMSSSDGFCSSLSFSPGELGQIHTIEKPHPISSNVGTPS 560
Cdd:PHA03307  240 SSSESSGCGWGPENECPLP-----RPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRA 314

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 315041713  561 TAPAVQSPILSSPRKNSAGKASLAAIGTPAPTPTAVPARAASSGPATPSSSTSKAAAVVNNPTP 624
Cdd:PHA03307  315 SSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSP 378
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 214-469 4.21e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 4.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  214 PAKRVASSSPVPDFGGNRVqstsGNPMTVSSPGAST-PGTPLTAPLPMDPPPVSLSRRSSFGSSPSIRRSASPAPSMPLP 292
Cdd:PHA03247 2739 PAPPAVPAGPATPGGPARP----ARPPTTAGPPAPApPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAP 2814

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  293 AVKPLEAASPGlfGGIGVKNASIYANETFNSFFRRLTFAPDGSLlfTPAGQYKvslagqndkvvediintvyvytRAGFN 372
Cdd:PHA03247 2815 AAALPPAASPA--GPLPPPTSAQPTAPPPPPGPPPPSLPLGGSV--APGGDVR----------------------RRPPS 2868

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  373 KPPIA------HLPGHKKPSVAVKCSPVYYTLRQgTKPTRQIFLDSSSAEEAFPPLPDSVISQPAMEPPlSAPPSATSET 446
Cdd:PHA03247 2869 RSPAAkpaapaRPPVRRLARPAVSRSTESFALPP-DQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPP-PRPQPPLAPT 2946

                         250       260
                  ....*....|....*....|...
gi 315041713  447 PRPFPQSGANESDTGSQNSPIPP 469
Cdd:PHA03247 2947 TDPAGAGEPSGAVPQPWLGALVP 2969
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
6-206 1.99e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.81  E-value: 1.99e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713   6 LLIAWHDDNAPIYSVHFDPHGKgRLATAGNDNNVRLWKVEsTGEErkvtyLSTLIKHTQAVNVVRFCPKGEMLASAGDDG 85
Cdd:COG2319  196 LLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDLA-TGKL-----LRTLTGHSGSVRSVAFSPDGRLLASGSADG 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  86 NVLLWvpsetqtqpgfgqealdDKETWRVKHMCRSSGAEIYDLAWSPDGVFIITGSMDNIARIYNAQTGQMVRQIAEHSH 165
Cdd:COG2319  269 TVRLW-----------------DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG 331

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 315041713 166 YVQGVAWDPLNEYVATQSSDRSVHIYALKTKDGQFTLTTHG 206
Cdd:COG2319  332 AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHT 372
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-222 1.59e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.98  E-value: 1.59e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713   6 LLIAWHDDNAPIYSVHFDPHGKgRLATAGNDNNVRLWKVESTgeerkvTYLSTLIKHTQAVNVVRFCPKGEMLASAGDDG 85
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETG------KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDG 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  86 NVLLWvpsetqtqpgfgqealdDKETWRVKHMCRSSGAEIYDLAWSPDGVFIITGSMDNIARIYNAQTGQMVRQIAEHSH 165
Cdd:cd00200  158 TIKLW-----------------DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN 220

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713 166 YVQGVAWDPLNEYVATQSSDRSVHIYALKTKDGQFTLTTHGKF---LKMDLPAKRVASSS 222
Cdd:cd00200  221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSvtsLAWSPDGKRLASGS 280
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 69-172 3.05e-07

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 48.81  E-value: 3.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713   69 VRFCPKGEMLASAGDDGNVLLWvpsetqtqpgfgqeALDDKETWRVKHmcRSSGAEIYDLAWSPDGVFIITGSMDNIARI 148
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLH--------------RLNWQRVWTLSP--DKEDLEVTSLAWRPDGKLLAVGYSDGTVRL 64

                          90       100
                  ....*....|....*....|....
gi 315041713  149 YNAQTGQMVRQIAEHSHYVQGVAW 172
Cdd:pfam12894  65 LDAENGKIVHHFSAGSDLITCLGW 88
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 56-90 7.80e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 7.80e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 315041713    56 LSTLIKHTQAVNVVRFCPKGEMLASAGDDGNVLLW 90
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00421 PTZ00421
coronin; Provisional
 16-163 3.73e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.81  E-value: 3.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  16 PIYSVHFDPHGKGRLATAGNDNNVRLWKVESTGEERKVT-YLSTLIKHTQAVNVVRFCPKGE-MLASAGDDGNVLLWvps 93
Cdd:PTZ00421  77 PIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISdPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVW--- 153

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  94 etqtqpgfgqealdDKETWRVKHMCRSSGAEIYDLAWSPDGVFIITGSMDNIARIYNAQTGQMVRQIAEH 163
Cdd:PTZ00421 154 --------------DVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
557-700 7.20e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 46.31  E-value: 7.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713 557 GTPSTAPA-VQSPILSSPRknSAGKASLAAIGTPAPTPTAVPARaassgPATPSSSTSKAaavvnnPTPILGTVPSVTAT 635
Cdd:PRK14971 369 ASGGRGPKqHIKPVFTQPA--AAPQPSAAAAASPSPSQSSAAAQ-----PSAPQSATQPA------GTPPTVSVDPPAAV 435

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 315041713 636 NSSQPFSTPPETPMSSHSATNSISGSVLGKRDLSTvseseKEDSHDKDEEDQTGNKTAHREPKRK 700
Cdd:PRK14971 436 PVNPPSTAPQAVRPAQFKEEKKIPVSKVSSLGPST-----LRPIQEKAEQATGNIKEAPTGTQKE 495
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 401-624 9.31e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.93  E-value: 9.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  401 GTKPTRQIFLDSSSAEEAFPPlpdsvISQPAMEPPLSAPPSATSETPRPFPQSGANESDTGSQNSPIPPVFALPYRMVYA 480
Cdd:PHA03307  165 DAASSRQAALPLSSPEETARA-----PSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDS 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  481 VATQDAVLVYDTQQQTPLCvvnnlHFATFTDLSWSHDGLTLIMSSSDGFCSSLSFSPGELGQIHTIEKPHPISSNVGTPS 560
Cdd:PHA03307  240 SSSESSGCGWGPENECPLP-----RPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRA 314

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 315041713  561 TAPAVQSPILSSPRKNSAGKASLAAIGTPAPTPTAVPARAASSGPATPSSSTSKAAAVVNNPTP 624
Cdd:PHA03307  315 SSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSP 378
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 580-671 3.52e-04

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 43.73  E-value: 3.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  580 KASLAAIGTPAPTPTAvparAASSGPATPSSSTSKAAAvvnnptpilgtVPSVTAtnssQPFSTPPETPMSSHSATNSIS 659
Cdd:TIGR00601  78 KTGTGKVAPPAATPTS----APTPTPSPPASPASGMSA-----------APASAV----EEKSPSEESATATAPESPSTS 138

                          90
                  ....*....|..
gi 315041713  660 GSVLGKRDLSTV 671
Cdd:TIGR00601 139 VPSSGSDAASTL 150
PHA03247 PHA03247
large tegument protein UL36; Provisional
 214-469 4.21e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 4.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  214 PAKRVASSSPVPDFGGNRVqstsGNPMTVSSPGAST-PGTPLTAPLPMDPPPVSLSRRSSFGSSPSIRRSASPAPSMPLP 292
Cdd:PHA03247 2739 PAPPAVPAGPATPGGPARP----ARPPTTAGPPAPApPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAP 2814

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  293 AVKPLEAASPGlfGGIGVKNASIYANETFNSFFRRLTFAPDGSLlfTPAGQYKvslagqndkvvediintvyvytRAGFN 372
Cdd:PHA03247 2815 AAALPPAASPA--GPLPPPTSAQPTAPPPPPGPPPPSLPLGGSV--APGGDVR----------------------RRPPS 2868

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  373 KPPIA------HLPGHKKPSVAVKCSPVYYTLRQgTKPTRQIFLDSSSAEEAFPPLPDSVISQPAMEPPlSAPPSATSET 446
Cdd:PHA03247 2869 RSPAAkpaapaRPPVRRLARPAVSRSTESFALPP-DQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPP-PRPQPPLAPT 2946

                         250       260
                  ....*....|....*....|...
gi 315041713  447 PRPFPQSGANESDTGSQNSPIPP 469
Cdd:PHA03247 2947 TDPAGAGEPSGAVPQPWLGALVP 2969
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 551-658 6.82e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.90  E-value: 6.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  551 PISSNVGTPSTAPAVQSPILSSPRKNS---AGKASLAAIGTPAPTP-------TAVPARAASSGPATPSSSTSKAAAVVN 620
Cdd:pfam05109 449 PSSTHVPTNLTAPASTGPTVSTADVTSptpAGTTSGASPVTPSPSPrdngtesKAPDMTSPTSAVTTPTPNATSPTPAVT 528

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 315041713  621 NPT-----PILGTVPSVTATNSSQPFSTPPETPMSSHSATNSI 658
Cdd:pfam05109 529 TPTpnatsPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATI 571
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
6-206 1.99e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.81  E-value: 1.99e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713   6 LLIAWHDDNAPIYSVHFDPHGKgRLATAGNDNNVRLWKVEsTGEErkvtyLSTLIKHTQAVNVVRFCPKGEMLASAGDDG 85
Cdd:COG2319  196 LLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDLA-TGKL-----LRTLTGHSGSVRSVAFSPDGRLLASGSADG 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  86 NVLLWvpsetqtqpgfgqealdDKETWRVKHMCRSSGAEIYDLAWSPDGVFIITGSMDNIARIYNAQTGQMVRQIAEHSH 165
Cdd:COG2319  269 TVRLW-----------------DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG 331

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 315041713 166 YVQGVAWDPLNEYVATQSSDRSVHIYALKTKDGQFTLTTHG 206
Cdd:COG2319  332 AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHT 372
WD40 COG2319
WD40 repeat [General function prediction only];
6-206 9.35e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.88  E-value: 9.35e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713   6 LLIAWHDDNAPIYSVHFDPHGKgRLATAGNDNNVRLWKVEsTGEErkvtyLSTLIKHTQAVNVVRFCPKGEMLASAGDDG 85
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGK-TLASGSADGTVRLWDLA-TGKL-----LRTLTGHSGAVTSVAFSPDGKLLASGSDDG 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  86 NVLLWvpsetqtqpgfgqealdDKETWRVKHMCRSSGAEIYDLAWSPDGVFIITGSMDNIARIYNAQTGQMVRQIAEHSH 165
Cdd:COG2319  185 TVRLW-----------------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSG 247

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 315041713 166 YVQGVAWDPLNEYVATQSSDRSVHIYALKTKDGQFTLTTHG 206
Cdd:COG2319  248 SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHS 288
WD40 COG2319
WD40 repeat [General function prediction only];
6-195 1.44e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 124.64  E-value: 1.44e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713   6 LLIAWHDDNAPIYSVHFDPHGKgRLATAGNDNNVRLWKVEsTGEErkvtyLSTLIKHTQAVNVVRFCPKGEMLASAGDDG 85
Cdd:COG2319  238 LLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLA-TGEL-----LRTLTGHSGGVNSVAFSPDGKLLASGSDDG 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  86 NVLLWvpsetqtqpgfgqealdDKETWRVKHMCRSSGAEIYDLAWSPDGVFIITGSMDNIARIYNAQTGQMVRQIAEHSH 165
Cdd:COG2319  311 TVRLW-----------------DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTG 373

                        170       180       190
                 ....*....|....*....|....*....|
gi 315041713 166 YVQGVAWDPLNEYVATQSSDRSVHIYALKT 195
Cdd:COG2319  374 AVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
3-206 6.45e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 122.71  E-value: 6.45e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713   3 ATPLLIAWHDDNAPIYSVHFDPHGKgRLATAGNDNNVRLWKVESTGEERkvtylsTLIKHTQAVNVVRFCPKGEMLASAG 82
Cdd:COG2319   67 AGALLATLLGHTAAVLSVAFSPDGR-LLASASADGTVRLWDLATGLLLR------TLTGHTGAVRSVAFSPDGKTLASGS 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  83 DDGNVLLWvpsetqtqpgfgqealdDKETWRVKHMCRSSGAEIYDLAWSPDGVFIITGSMDNIARIYNAQTGQMVRQIAE 162
Cdd:COG2319  140 ADGTVRLW-----------------DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG 202

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 315041713 163 HSHYVQGVAWDPLNEYVATQSSDRSVHIYALKTKDGQFTLTTHG 206
Cdd:COG2319  203 HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-222 1.59e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.98  E-value: 1.59e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713   6 LLIAWHDDNAPIYSVHFDPHGKgRLATAGNDNNVRLWKVESTgeerkvTYLSTLIKHTQAVNVVRFCPKGEMLASAGDDG 85
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETG------KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDG 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  86 NVLLWvpsetqtqpgfgqealdDKETWRVKHMCRSSGAEIYDLAWSPDGVFIITGSMDNIARIYNAQTGQMVRQIAEHSH 165
Cdd:cd00200  158 TIKLW-----------------DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN 220

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713 166 YVQGVAWDPLNEYVATQSSDRSVHIYALKTKDGQFTLTTHGKF---LKMDLPAKRVASSS 222
Cdd:cd00200  221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSvtsLAWSPDGKRLASGS 280
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-192 1.06e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.28  E-value: 1.06e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  14 NAPIYSVHFDPHGKgRLATAGNDNNVRLWKVEsTGEERKvtylsTLIKHTQAVNVVRFCPKGEMLASAGDDGNVLLWvps 93
Cdd:cd00200  135 TDWVNSVAFSPDGT-FVASSSQDGTIKLWDLR-TGKCVA-----TLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW--- 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  94 etqtqpgfgqealdDKETWRVKHMCRSSGAEIYDLAWSPDGVFIITGSMDNIARIYNAQTGQMVRQIAEHSHYVQGVAWD 173
Cdd:cd00200  205 --------------DLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWS 270

                        170
                 ....*....|....*....
gi 315041713 174 PLNEYVATQSSDRSVHIYA 192
Cdd:cd00200  271 PDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-205 1.32e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.20  E-value: 1.32e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  14 NAPIYSVHFDPHGKgRLATAGNDNNVRLWKVEsTGEerkvtYLSTLIKHTQAVNVVRFCPKGEMLASAGDDGNVLLWvps 93
Cdd:cd00200    9 TGGVTCVAFSPDGK-LLATGSGDGTIKVWDLE-TGE-----LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW--- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  94 etqtqpgfgqealdDKETWRVKHMCRSSGAEIYDLAWSPDGVFIITGSMDNIARIYNAQTGQMVRQIAEHSHYVQGVAWD 173
Cdd:cd00200   79 --------------DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS 144

                        170       180       190
                 ....*....|....*....|....*....|..
gi 315041713 174 PLNEYVATQSSDRSVHIYALKTKDGQFTLTTH 205
Cdd:cd00200  145 PDGTFVASSSQDGTIKLWDLRTGKCVATLTGH 176
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 58-222 3.50e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.41  E-value: 3.50e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  58 TLIKHTQAVNVVRFCPKGEMLASAGDDGNVLLWvpsetqtqpgfgqealdDKETWRVKHMCRSSGAEIYDLAWSPDGVFI 137
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW-----------------DLETGELLRTLKGHTGPVRDVAASADGTYL 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713 138 ITGSMDNIARIYNAQTGQMVRQIAEHSHYVQGVAWDPLNEYVATQSSDRSVHIYALKTKDGQFTLTTHGKF---LKMDLP 214
Cdd:cd00200   67 ASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWvnsVAFSPD 146


                 ....*...
gi 315041713 215 AKRVASSS 222
Cdd:cd00200  147 GTFVASSS 154
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 115-205 1.53e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 1.53e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713 115 KHMCRSSGAEIYDLAWSPDGVFIITGSMDNIARIYNAQTGQMVRQIAEHSHYVQGVAWDPLNEYVATQSSDRSVHIYALK 194
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                         90
                 ....*....|.
gi 315041713 195 TKDGQFTLTTH 205
Cdd:cd00200   82 TGECVRTLTGH 92
WD40 COG2319
WD40 repeat [General function prediction only];
29-205 4.51e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.40  E-value: 4.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  29 RLATAGNDNNVRLWKVESTGEerkvtyLSTLIKHTQAVNVVRFCPKGEMLASAGDDGNVLLWVPSETQTQPGFgqealdd 108
Cdd:COG2319    8 ALAAASADLALALLAAALGAL------LLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATL------- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713 109 ketwrvkhmcRSSGAEIYDLAWSPDGVFIITGSMDNIARIYNAQTGQMVRQIAEHSHYVQGVAWDPLNEYVATQSSDRSV 188
Cdd:COG2319   75 ----------LGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                        170
                 ....*....|....*..
gi 315041713 189 HIYALKTKDGQFTLTTH 205
Cdd:COG2319  145 RLWDLATGKLLRTLTGH 161
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 69-172 3.05e-07

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 48.81  E-value: 3.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713   69 VRFCPKGEMLASAGDDGNVLLWvpsetqtqpgfgqeALDDKETWRVKHmcRSSGAEIYDLAWSPDGVFIITGSMDNIARI 148
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLH--------------RLNWQRVWTLSP--DKEDLEVTSLAWRPDGKLLAVGYSDGTVRL 64

                          90       100
                  ....*....|....*....|....
gi 315041713  149 YNAQTGQMVRQIAEHSHYVQGVAW 172
Cdd:pfam12894  65 LDAENGKIVHHFSAGSDLITCLGW 88
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 56-90 7.80e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 7.80e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 315041713    56 LSTLIKHTQAVNVVRFCPKGEMLASAGDDGNVLLW 90
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 111-150 7.23e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 7.23e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 315041713   111 TWRVKHMCRSSGAEIYDLAWSPDGVFIITGSMDNIARIYN 150
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
54-90 3.60e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 3.60e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 315041713   54 TYLSTLIKHTQAVNVVRFCPKGEMLASAGDDGNVLLW 90
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00421 PTZ00421
coronin; Provisional
 16-163 3.73e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.81  E-value: 3.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  16 PIYSVHFDPHGKGRLATAGNDNNVRLWKVESTGEERKVT-YLSTLIKHTQAVNVVRFCPKGE-MLASAGDDGNVLLWvps 93
Cdd:PTZ00421  77 PIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISdPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVW--- 153

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  94 etqtqpgfgqealdDKETWRVKHMCRSSGAEIYDLAWSPDGVFIITGSMDNIARIYNAQTGQMVRQIAEH 163
Cdd:PTZ00421 154 --------------DVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 153-191 3.99e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 3.99e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 315041713   153 TGQMVRQIAEHSHYVQGVAWDPLNEYVATQSSDRSVHIY 191
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
557-700 7.20e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 46.31  E-value: 7.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713 557 GTPSTAPA-VQSPILSSPRknSAGKASLAAIGTPAPTPTAVPARaassgPATPSSSTSKAaavvnnPTPILGTVPSVTAT 635
Cdd:PRK14971 369 ASGGRGPKqHIKPVFTQPA--AAPQPSAAAAASPSPSQSSAAAQ-----PSAPQSATQPA------GTPPTVSVDPPAAV 435

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 315041713 636 NSSQPFSTPPETPMSSHSATNSISGSVLGKRDLSTvseseKEDSHDKDEEDQTGNKTAHREPKRK 700
Cdd:PRK14971 436 PVNPPSTAPQAVRPAQFKEEKKIPVSKVSSLGPST-----LRPIQEKAEQATGNIKEAPTGTQKE 495
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 156-210 8.52e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 8.52e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 315041713 156 MVRQIAEHSHYVQGVAWDPLNEYVATQSSDRSVHIYALKTKDGQFTLTTHGKFLK 210
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVR 55
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 401-624 9.31e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.93  E-value: 9.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  401 GTKPTRQIFLDSSSAEEAFPPlpdsvISQPAMEPPLSAPPSATSETPRPFPQSGANESDTGSQNSPIPPVFALPYRMVYA 480
Cdd:PHA03307  165 DAASSRQAALPLSSPEETARA-----PSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDS 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  481 VATQDAVLVYDTQQQTPLCvvnnlHFATFTDLSWSHDGLTLIMSSSDGFCSSLSFSPGELGQIHTIEKPHPISSNVGTPS 560
Cdd:PHA03307  240 SSSESSGCGWGPENECPLP-----RPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRA 314

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 315041713  561 TAPAVQSPILSSPRKNSAGKASLAAIGTPAPTPTAVPARAASSGPATPSSSTSKAAAVVNNPTP 624
Cdd:PHA03307  315 SSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSP 378
WD40 pfam00400
WD domain, G-beta repeat;
112-150 1.54e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.54e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 315041713  112 WRVKHMCRSSGAEIYDLAWSPDGVFIITGSMDNIARIYN 150
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 10-43 2.44e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 2.44e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 315041713    10 WHDDNAPIYSVHFDPHGKgRLATAGNDNNVRLWK 43
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 580-671 3.52e-04

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 43.73  E-value: 3.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  580 KASLAAIGTPAPTPTAvparAASSGPATPSSSTSKAAAvvnnptpilgtVPSVTAtnssQPFSTPPETPMSSHSATNSIS 659
Cdd:TIGR00601  78 KTGTGKVAPPAATPTS----APTPTPSPPASPASGMSA-----------APASAV----EEKSPSEESATATAPESPSTS 138

                          90
                  ....*....|..
gi 315041713  660 GSVLGKRDLSTV 671
Cdd:TIGR00601 139 VPSSGSDAASTL 150
PHA03247 PHA03247
large tegument protein UL36; Provisional
 214-469 4.21e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 4.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  214 PAKRVASSSPVPDFGGNRVqstsGNPMTVSSPGAST-PGTPLTAPLPMDPPPVSLSRRSSFGSSPSIRRSASPAPSMPLP 292
Cdd:PHA03247 2739 PAPPAVPAGPATPGGPARP----ARPPTTAGPPAPApPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAP 2814

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  293 AVKPLEAASPGlfGGIGVKNASIYANETFNSFFRRLTFAPDGSLlfTPAGQYKvslagqndkvvediintvyvytRAGFN 372
Cdd:PHA03247 2815 AAALPPAASPA--GPLPPPTSAQPTAPPPPPGPPPPSLPLGGSV--APGGDVR----------------------RRPPS 2868

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  373 KPPIA------HLPGHKKPSVAVKCSPVYYTLRQgTKPTRQIFLDSSSAEEAFPPLPDSVISQPAMEPPlSAPPSATSET 446
Cdd:PHA03247 2869 RSPAAkpaapaRPPVRRLARPAVSRSTESFALPP-DQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPP-PRPQPPLAPT 2946

                         250       260
                  ....*....|....*....|...
gi 315041713  447 PRPFPQSGANESDTGSQNSPIPP 469
Cdd:PHA03247 2947 TDPAGAGEPSGAVPQPWLGALVP 2969
motB PRK12799
flagellar motor protein MotB; Reviewed
 555-661 4.37e-04

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 43.17  E-value: 4.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713 555 NVGTPSTAPAVQSPILSSPRKNSAGKASLAAIGTPAPTPTAVPARAASSgpaTPSSSTSKAAAVVNNPTPILGTVPSVTA 634
Cdd:PRK12799 292 QIDTHGTVPVAAVTPSSAVTQSSAITPSSAAIPSPAVIPSSVTTQSATT---TQASAVALSSAGVLPSDVTLPGTVALPA 368

                         90       100
                 ....*....|....*....|....*..
gi 315041713 635 TNSSQPFSTPPETPMSSHSATNSISGS 661
Cdd:PRK12799 369 AEPVNMQPQPMSTTETQQSSTGNITST 395
PRK10118 PRK10118
flagellar hook length control protein FliK;
549-659 5.09e-04

flagellar hook length control protein FliK;


Pssm-ID: 236652 [Multi-domain]  Cd Length: 408  Bit Score: 42.93  E-value: 5.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713 549 PHPISSNVGTPSTAPAVQSPILSSP--RKNSAGKASLAAIGTPAPTPTAVPARAASSGPATP----SSSTSKAAAVVNNP 622
Cdd:PRK10118 158 PVADAPSTVLPAEKPTLLTKDMPSApqDETHTLSSDEHEKGLTSAQLTTAQPDDAPGTPAQPltplAAEAQAKAEVISTP 237

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 315041713 623 TPILGTVPSVTATNSSQPFSTPP----ETPMSSHSATNSIS 659
Cdd:PRK10118 238 SPVTAAASPTITPHQTQPLPTAAapvlSAPLGSHEWQQSLS 278
motB PRK12799
flagellar motor protein MotB; Reviewed
 543-657 1.09e-03

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 42.01  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713 543 IHTIEKPHPISSNVGTPSTAPAVQSPILSS--PRKNSAGKASLAAIGTPAPTPTAVPARAassgPATPSSSTSKAAAVVN 620
Cdd:PRK12799 284 IEKATGLKQIDTHGTVPVAAVTPSSAVTQSsaITPSSAAIPSPAVIPSSVTTQSATTTQA----SAVALSSAGVLPSDVT 359

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 315041713 621 NPTPIlgTVPSVTATNSSQPFSTPPETPMSSHSATNS 657
Cdd:PRK12799 360 LPGTV--ALPAAEPVNMQPQPMSTTETQQSSTGNITS 394
PHA03255 PHA03255
BDLF3; Provisional
 519-685 1.40e-03

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 41.04  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713 519 LTLIMSSSDGFCSSLSfSPGELGQIHTIEKPHPISSNVGTPSTAPAVQSPILSSPRKNSAGKASLAAIGTPapTPTAVPA 598
Cdd:PHA03255  14 MILICETSLIWTSSGS-STASAGNVTGTTAVTTPSPSASGPSTNQSTTLTTTSAPITTTAILSTNTTTVTS--TGTTVTP 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713 599 RAASSGPATPSSSTSKAAAVVNNPTPILGTVPSVTATNSSQPFSTppeTPMSSHSATNSISGSVLGKRDLSTVSESEKED 678
Cdd:PHA03255  91 VPTTSNASTINVTTKVTAQNITATEAGTGTSTGVTSNVTTRSSST---TSATTRITNATTLAPTLSSKGTSNATKTTAEL 167


                 ....*..
gi 315041713 679 SHDKDEE 685
Cdd:PHA03255 168 PTVPDER 174
PHA03247 PHA03247
large tegument protein UL36; Provisional
 412-657 1.47e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  412 SSSAEEAFPPLP-DSVISQPAMEPPLSAPPSATSETPRPF-PQSGANESDTGS----------QNSPIPPVFALPYRmvy 479
Cdd:PHA03247 2590 DAPPQSARPRAPvDDRGDPRGPAPPSPLPPDTHAPDPPPPsPSPAANEPDPHPpptvppperpRDDPAPGRVSRPRR--- 2666

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  480 aVATQDAVLVYDTQQQTPLCVVNNLHFATFTDLSWSHDGLTLIMSSSDGFCSSLSFSPGELGQIHTIEKP--HPISSNVG 557
Cdd:PHA03247 2667 -ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALpaAPAPPAVP 2745

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  558 TPSTAPAVQSPILSSPRKNSAGKASLAAIGTPAPTPTAVPARAASSGPATPSSSTSKAAAVVnnPTPILGTVPSVTATNS 637
Cdd:PHA03247 2746 AGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP--PAAVLAPAAALPPAAS 2823

                         250       260
                  ....*....|....*....|
gi 315041713  638 SQPFSTPPETPMSSHSATNS 657
Cdd:PHA03247 2824 PAGPLPPPTSAQPTAPPPPP 2843
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 120-206 2.41e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 39.27  E-value: 2.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713 120 SSGAEIYDLAWSPDGVFII-TGSMDNIARIY--NAQTGQmVRQIAEHSHYVQGVAWDPLNEYVA-TQSSDRSVHIYALKT 195
Cdd:COG0823   28 NSPGIDTSPAWSPDGRRIAfTSDRGGGPQIYvvDADGGE-PRRLTFGGGYNASPSWSPDGKRLAfVSRSDGRFDIYVLDL 106

                         90
                 ....*....|.
gi 315041713 196 KDGQFTLTTHG 206
Cdd:COG0823  107 DGGAPRRLTDG 117
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 397-725 4.56e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 4.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  397 TLRQGTKPTRQIFLDSSSAEEAFPPLPDSVISQPAMEPPLSAPPSATSETPRPFPQSganeSDTGSQNSPIPPVFALPYR 476
Cdd:PHA03307   64 RFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPT----PPPASPPPSPAPDLSEMLR 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  477 MVYAVATQDavlvydtqQQTPLCVVNNLHFATFTDLSWSHDGLTLIMSSSDGFCSSlsfSPGELGQIHTIEKPHPISSNV 556
Cdd:PHA03307  140 PVGSPGPPP--------AASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPS---SPPAEPPPSTPPAAASPRPPR 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  557 GTPSTAPAVQSPILSSPRKNSAGKASLAAIGTPAPTP---TAVPARAASSGPATPSSSTSKAAAVV-NNPTPILGTVPSV 632
Cdd:PHA03307  209 RSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSgcgWGPENECPLPRPAPITLPTRIWEASGwNGPSSRPGPASSS 288

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  633 TATNSSQPFSTPPETPMSSHSATNSISGSVLGKRDLStvSESEKEDSHDKDEEDQTGNKTAHREPKRKRIAPTLI--SPA 710
Cdd:PHA03307  289 SSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESS--SSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADpsSPR 366

                         330
                  ....*....|....*
gi 315041713  711 SSGMPNSEDSSKPSS 725
Cdd:PHA03307  367 KRPRPSRAPSSPAAS 381
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 557-647 5.77e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.08  E-value: 5.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713 557 GTPSTAPAVQSPILSSPRKNSAGKASLAAIGTPAPTPTAVPARAASSGPATPSSSTSKAAAVVNNPTPILGTVPSVTATN 636
Cdd:PRK14951 369 AAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALA 448

                         90
                 ....*....|.
gi 315041713 637 SSQPFSTPPET 647
Cdd:PRK14951 449 PAPPAQAAPET 459
WD40 pfam00400
WD domain, G-beta repeat;
154-191 6.12e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 6.12e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 315041713  154 GQMVRQIAEHSHYVQGVAWDPLNEYVATQSSDRSVHIY 191
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 551-658 6.82e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.90  E-value: 6.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  551 PISSNVGTPSTAPAVQSPILSSPRKNS---AGKASLAAIGTPAPTP-------TAVPARAASSGPATPSSSTSKAAAVVN 620
Cdd:pfam05109 449 PSSTHVPTNLTAPASTGPTVSTADVTSptpAGTTSGASPVTPSPSPrdngtesKAPDMTSPTSAVTTPTPNATSPTPAVT 528

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 315041713  621 NPT-----PILGTVPSVTATNSSQPFSTPPETPMSSHSATNSI 658
Cdd:pfam05109 529 TPTpnatsPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATI 571
PHA03247 PHA03247
large tegument protein UL36; Provisional
 216-459 6.88e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 6.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  216 KRVASSSPVPdfGGNRVQSTsgnPMTVSSPGASTPGTPLTAPLPMDPP----PVSLSRRSS-------FGSSPSIrrSAS 284
Cdd:PHA03247  240 RRVVISHPLR--GDIAAPAP---PPVVGEGADRAPETARGATGPPPPPeaaaPNGAAAPPDgvwgaalAGAPLAL--PAP 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  285 PAPSMPLPAVKPLEAAspGLFGGIGVKNASIYANETFNSFF---RRLTFAPDGSLlftpagqykvslagqndkvvEDIin 361
Cdd:PHA03247  313 PDPPPPAPAGDAEEED--DEDGAMEVVSPLPRPRQHYPLGFpkrRRPTWTPPSSL--------------------EDL-- 368

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315041713  362 tvyvytRAGFNKPPIAHLPGHKKPSVAVKCSPVYYTLRQGTKPTRQIFLDSSSAEEAFPPLPDSVISQPAMEPPLSAPPS 441
Cdd:PHA03247  369 ------SAGRHHPKRASLPTRKRRSARHAATPFARGPGGDDQTRPAAPVPASVPTPAPTPVPASAPPPPATPLPSAEPGS 442

                         250
                  ....*....|....*...
gi 315041713  442 ATSETPRPFPQSGANESD 459
Cdd:PHA03247  443 DDGPAPPPERQPPAPATE 460
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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