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Conserved domains on  [gi|1376943971|ref|XP_002978577|]
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pyruvate dehydrogenase (acetyl-transferring) kinase, mitochondrial [Selaginella moellendorffii]

Protein Classification

PDK/BCKDK family protein kinase( domain architecture ID 13768654)

PDK/BCKDK family protein kinase contains a histidine kinase-like ATPase domain and catalyzes the phosphorylation of protein substrates, such as branched-chain alpha-ketoacid dehydrogenase (BCKD) kinase that catalyzes the phosphorylation and inactivation of the BCKD complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways

CATH:  3.30.565.10|1.20.140.20
EC:  2.7.11.-
Gene Ontology:  GO:0004672|GO:0005524|GO:0006468
PubMed:  10339418|10637609

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 210-375 6.62e-74

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


:

Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 227.22  E-value: 6.62e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 210 SPVLIAQNAIDDARSACMRTYGSAPEVHVYGDPNFAFAYVPTHLHQMLFELLKNSLRAVQERFMDSDQESPPIRIIVADG 289
Cdd:cd16929     1 SPKKVVEDASEEARVLCDDYYLSSPELEIEGDPSIRFPYVPSHLYYILFELLKNAMRATVESHGDDSDDLPPIKVTVAKG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 290 VEDVTVKISDEGGGIPRSGLSKIWTYLYTTAKSPLEESRHMQ---ETPNVMAGYGYGLPISRLYARYFGGDLQVISMEGY 366
Cdd:cd16929    81 DEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPSLDDFSDLisgTQPSPLAGFGYGLPMSRLYAEYFGGDLDLQSMEGY 160


                  ....*....
gi 1376943971 367 GTDAYLHLN 375
Cdd:cd16929   161 GTDVYIYLK 169
BCDHK_Adom3 pfam10436
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ...
 45-205 2.94e-71

Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.


:

Pssm-ID: 463093  Cd Length: 158  Bit Score: 220.07  E-value: 2.94e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971  45 GVSLKYMMDFGANPTEKSLLLSSQFLHKELPVRLAHRVMELDNLPYGLSEKAPVLKVRDWYVDSFKDLRTFPEIqDAADE 124
Cdd:pfam10436   1 PLSLRQLLDFGRSLSEEKLLKSANFLREELPVRLAHRIRELQNLPYILVSNPSISKVYEWYLQSFEELLSFPPP-ILEDN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 125 MKFTDLIHQIKIRHNNVTPTVAMGVQELKEELGRRggllelpEIHQFLDRFYMSRIGIRMLIGQHVALHQ----PNPAPG 200
Cdd:pfam10436  80 EKFTELLEEILDRHNDVVPTLAQGVLELKKYLSPE-------EIQSFLDRFLRSRIGIRLLAEQHIALTEqsnnPSHPPD 152


                  ....*
gi 1376943971 201 YIGLI 205
Cdd:pfam10436 153 YVGII 157
 
Name Accession Description Interval E-value
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 210-375 6.62e-74

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 227.22  E-value: 6.62e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 210 SPVLIAQNAIDDARSACMRTYGSAPEVHVYGDPNFAFAYVPTHLHQMLFELLKNSLRAVQERFMDSDQESPPIRIIVADG 289
Cdd:cd16929     1 SPKKVVEDASEEARVLCDDYYLSSPELEIEGDPSIRFPYVPSHLYYILFELLKNAMRATVESHGDDSDDLPPIKVTVAKG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 290 VEDVTVKISDEGGGIPRSGLSKIWTYLYTTAKSPLEESRHMQ---ETPNVMAGYGYGLPISRLYARYFGGDLQVISMEGY 366
Cdd:cd16929    81 DEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPSLDDFSDLisgTQPSPLAGFGYGLPMSRLYAEYFGGDLDLQSMEGY 160


                  ....*....
gi 1376943971 367 GTDAYLHLN 375
Cdd:cd16929   161 GTDVYIYLK 169
BCDHK_Adom3 pfam10436
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ...
 45-205 2.94e-71

Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.


Pssm-ID: 463093  Cd Length: 158  Bit Score: 220.07  E-value: 2.94e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971  45 GVSLKYMMDFGANPTEKSLLLSSQFLHKELPVRLAHRVMELDNLPYGLSEKAPVLKVRDWYVDSFKDLRTFPEIqDAADE 124
Cdd:pfam10436   1 PLSLRQLLDFGRSLSEEKLLKSANFLREELPVRLAHRIRELQNLPYILVSNPSISKVYEWYLQSFEELLSFPPP-ILEDN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 125 MKFTDLIHQIKIRHNNVTPTVAMGVQELKEELGRRggllelpEIHQFLDRFYMSRIGIRMLIGQHVALHQ----PNPAPG 200
Cdd:pfam10436  80 EKFTELLEEILDRHNDVVPTLAQGVLELKKYLSPE-------EIQSFLDRFLRSRIGIRLLAEQHIALTEqsnnPSHPPD 152


                  ....*
gi 1376943971 201 YIGLI 205
Cdd:pfam10436 153 YVGII 157
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 250-374 3.91e-19

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 81.93  E-value: 3.91e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971  250 PTHLHQMLFELLKNSLRAVQErfmdsdqeSPPIRIIVADGVEDVTVKISDEGGGIPRSGLSKIWTYLYTTAKspleesrh 329
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTPE--------GGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-------- 66

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1376943971  330 mqeTPNVMAGYGYGLPISRLYARYFGGDLQVISMEGYGTDAYLHL 374
Cdd:smart00387  67 ---RSRKIGGTGLGLSIVKKLVELHGGEISVESEPGGGTTFTITL 108
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 249-374 1.17e-16

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 75.10  E-value: 1.17e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 249 VPTHLHQMLFELLKNSLRAvqerfmdsDQESPPIRIIVADGvEDVTVKISDEGGGIPRSGLSKIWTylyttakspleesR 328
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKH--------AAKAGEITVTLSEG-GELTLTVEDNGIGIPPEDLPRIFE-------------P 59

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1376943971 329 HMQETPNVMAGYGYGLPISRLYARYFGGDLQVISMEGYGTDAYLHL 374
Cdd:pfam02518  60 FSTADKRGGGGTGLGLSIVRKLVELLGGTITVESEPGGGTTVTLTL 105
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
60-374 5.26e-11

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 63.39  E-value: 5.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971  60 EKSLLLSSQFLHKELPVRLAHRVMELDNLPYGLSEKAPVLKVRDWYVDSFKDLRTFPEIQDAADEMK---FTDLIHQIKi 136
Cdd:COG0642    44 LLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKsrfLANVSHELR- 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 137 rhnnvTP-TVAMG-VQELKEELGrrggllelPEIHQFLDRfyMSRIGIRM--LIGQHVALHQPNPapGYIGLISTRVSPV 212
Cdd:COG0642   123 -----TPlTAIRGyLELLLEELD--------EEQREYLET--ILRSADRLlrLINDLLDLSRLEA--GKLELEPEPVDLA 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 213 LIAQNAIDDARSACMR------TYGSAPEVHVYGDPNfafayvptHLHQMLFELLKNSLRavqerFMDSDQespPIRIIV 286
Cdd:COG0642   186 ELLEEVVELFRPLAEEkgieleLDLPDDLPTVRGDPD--------RLRQVLLNLLSNAIK-----YTPEGG---TVTVSV 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 287 ADGVEDVTVKISDEGGGIPRSGLSKIWTYLYTTAKSPLEEsrhmqetpnvmaGYGYGLPISRLYARYFGGDLQVISMEGY 366
Cdd:COG0642   250 RREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGG------------GTGLGLAIVKRIVELHGGTIEVESEPGK 317


                  ....*...
gi 1376943971 367 GTDAYLHL 374
Cdd:COG0642   318 GTTFTVTL 325
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 250-368 1.81e-05

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 46.86  E-value: 1.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 250 PTHLHQMLFELLKNSLRAVQerfmdsdQESPPIRIIvADGVEDVTVKISDEGGGIPRSGLSKIWTYLYTTAKSPleESRH 329
Cdd:PRK11091  396 GTRLRQILWNLISNAVKFTQ-------QGGVTVRVR-YEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSH--GGKP 465

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1376943971 330 mqetpnvMAGYGYGLPISRLYARYFGGDLQVISMEGYGT 368
Cdd:PRK11091  466 -------ATGTGIGLAVSKRLAQAMGGDITVTSEEGKGS 497
 
Name Accession Description Interval E-value
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 210-375 6.62e-74

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 227.22  E-value: 6.62e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 210 SPVLIAQNAIDDARSACMRTYGSAPEVHVYGDPNFAFAYVPTHLHQMLFELLKNSLRAVQERFMDSDQESPPIRIIVADG 289
Cdd:cd16929     1 SPKKVVEDASEEARVLCDDYYLSSPELEIEGDPSIRFPYVPSHLYYILFELLKNAMRATVESHGDDSDDLPPIKVTVAKG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 290 VEDVTVKISDEGGGIPRSGLSKIWTYLYTTAKSPLEESRHMQ---ETPNVMAGYGYGLPISRLYARYFGGDLQVISMEGY 366
Cdd:cd16929    81 DEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPSLDDFSDLisgTQPSPLAGFGYGLPMSRLYAEYFGGDLDLQSMEGY 160


                  ....*....
gi 1376943971 367 GTDAYLHLN 375
Cdd:cd16929   161 GTDVYIYLK 169
BCDHK_Adom3 pfam10436
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ...
 45-205 2.94e-71

Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.


Pssm-ID: 463093  Cd Length: 158  Bit Score: 220.07  E-value: 2.94e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971  45 GVSLKYMMDFGANPTEKSLLLSSQFLHKELPVRLAHRVMELDNLPYGLSEKAPVLKVRDWYVDSFKDLRTFPEIqDAADE 124
Cdd:pfam10436   1 PLSLRQLLDFGRSLSEEKLLKSANFLREELPVRLAHRIRELQNLPYILVSNPSISKVYEWYLQSFEELLSFPPP-ILEDN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 125 MKFTDLIHQIKIRHNNVTPTVAMGVQELKEELGRRggllelpEIHQFLDRFYMSRIGIRMLIGQHVALHQ----PNPAPG 200
Cdd:pfam10436  80 EKFTELLEEILDRHNDVVPTLAQGVLELKKYLSPE-------EIQSFLDRFLRSRIGIRLLAEQHIALTEqsnnPSHPPD 152


                  ....*
gi 1376943971 201 YIGLI 205
Cdd:pfam10436 153 YVGII 157
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 250-374 3.91e-19

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 81.93  E-value: 3.91e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971  250 PTHLHQMLFELLKNSLRAVQErfmdsdqeSPPIRIIVADGVEDVTVKISDEGGGIPRSGLSKIWTYLYTTAKspleesrh 329
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTPE--------GGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-------- 66

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1376943971  330 mqeTPNVMAGYGYGLPISRLYARYFGGDLQVISMEGYGTDAYLHL 374
Cdd:smart00387  67 ---RSRKIGGTGLGLSIVKKLVELHGGEISVESEPGGGTTFTITL 108
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 249-374 1.17e-16

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 75.10  E-value: 1.17e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 249 VPTHLHQMLFELLKNSLRAvqerfmdsDQESPPIRIIVADGvEDVTVKISDEGGGIPRSGLSKIWTylyttakspleesR 328
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKH--------AAKAGEITVTLSEG-GELTLTVEDNGIGIPPEDLPRIFE-------------P 59

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1376943971 329 HMQETPNVMAGYGYGLPISRLYARYFGGDLQVISMEGYGTDAYLHL 374
Cdd:pfam02518  60 FSTADKRGGGGTGLGLSIVRKLVELLGGTITVESEPGGGTTVTLTL 105
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
60-374 5.26e-11

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 63.39  E-value: 5.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971  60 EKSLLLSSQFLHKELPVRLAHRVMELDNLPYGLSEKAPVLKVRDWYVDSFKDLRTFPEIQDAADEMK---FTDLIHQIKi 136
Cdd:COG0642    44 LLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKsrfLANVSHELR- 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 137 rhnnvTP-TVAMG-VQELKEELGrrggllelPEIHQFLDRfyMSRIGIRM--LIGQHVALHQPNPapGYIGLISTRVSPV 212
Cdd:COG0642   123 -----TPlTAIRGyLELLLEELD--------EEQREYLET--ILRSADRLlrLINDLLDLSRLEA--GKLELEPEPVDLA 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 213 LIAQNAIDDARSACMR------TYGSAPEVHVYGDPNfafayvptHLHQMLFELLKNSLRavqerFMDSDQespPIRIIV 286
Cdd:COG0642   186 ELLEEVVELFRPLAEEkgieleLDLPDDLPTVRGDPD--------RLRQVLLNLLSNAIK-----YTPEGG---TVTVSV 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 287 ADGVEDVTVKISDEGGGIPRSGLSKIWTYLYTTAKSPLEEsrhmqetpnvmaGYGYGLPISRLYARYFGGDLQVISMEGY 366
Cdd:COG0642   250 RREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGG------------GTGLGLAIVKRIVELHGGTIEVESEPGK 317


                  ....*...
gi 1376943971 367 GTDAYLHL 374
Cdd:COG0642   318 GTTFTVTL 325
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
233-374 1.09e-09

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 58.38  E-value: 1.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 233 APEVHVYGDPnfafayvpTHLHQMLFELLKNSLRavqerFMDsdqESPPIRIIVADGVEDVTVKISDEGGGIPRSGLSKI 312
Cdd:COG2205   121 PELPLVYADP--------ELLEQVLANLLDNAIK-----YSP---PGGTITISARREGDGVRISVSDNGPGIPEEELERI 184

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1376943971 313 WTYLYTTAKSPLEEsrhmqetpnvmaGYGYGLPISRLYARYFGGDLQVISMEGYGTDAYLHL 374
Cdd:COG2205   185 FERFYRGDNSRGEG------------GTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 250-368 1.29e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 55.12  E-value: 1.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 250 PTHLHQMLFELLKNSLRAVQERfmdsdqesPPIRIIVADGVEDVTVKISDEGGGIPRSGLSKIWTYLYTTAKspleesrh 329
Cdd:cd16943     1 PSQLNQVLLNLLVNAAQAMEGR--------GRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKP-------- 64

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1376943971 330 mqetpnVMAGYGYGLPISRLYARYFGGDLQVISMEGYGT 368
Cdd:cd16943    65 ------VGEGTGLGLSLSYRIIQKHGGTIRVASVPGGGT 97
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 250-368 3.60e-09

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 57.89  E-value: 3.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 250 PTHLHQMLFELLKNSLRAVQERfmdsdqESPPIRIIVADGVEDVTVKISDEGGGIPRSGLSKIWTYLYTTaKSPLEesrh 329
Cdd:COG4191   254 PGQLEQVLLNLLINAIDAMEEG------EGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTT-KPVGK---- 322

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1376943971 330 mqetpnvmaGYGYGLPISRLYARYFGGDLQVISMEGYGT 368
Cdd:COG4191   323 ---------GTGLGLSISYGIVEKHGGRIEVESEPGGGT 352
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 233-381 1.63e-08

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 56.12  E-value: 1.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 233 APEVHVYGDPnfafayvpTHLHQMLFELLKNSLRAVQERfmdsdqesPPIRIIVADGVEDVTVKISDEGGGIPRSGLSKI 312
Cdd:COG5000   306 PDLPEVLADR--------DQLEQVLINLLKNAIEAIEEG--------GEIEVSTRREDGRVRIEVSDNGPGIPEEVLERI 369

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1376943971 313 WTYLYTTAKSpleesrhmqetpnvmaGYGYGLPISRLYARYFGGDLQVISMEGYGTDAYLHLNRLGNEQ 381
Cdd:COG5000   370 FEPFFTTKPK----------------GTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 238-374 8.03e-08

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 53.83  E-value: 8.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 238 VYGDPNfafayvptHLHQMLFELLKNSLRAvqerfMDSDQEsppirIIVADGVED---VTVKISDEGGGIPRSGLSKIWT 314
Cdd:COG5809   373 ILGDEN--------QLKQVFINLLKNAIEA-----MPEGGN-----ITIETKAEDddkVVISVTDEGCGIPEERLKKLGE 434

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 315 YLYTTaKsplEEsrhmqetpnvmaGYGYGLPISRLYARYFGGDLQVISMEGYGTDAYLHL 374
Cdd:COG5809   435 PFYTT-K---EK------------GTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITL 478
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 238-368 1.16e-07

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 53.58  E-value: 1.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 238 VYGDPNfafayvptHLHQMLFELLKNSLRAvqerfMDSDQEsppIRIIVADGVEDVTVKISDEGGGIPRSGLSKIWTYLY 317
Cdd:COG5805   389 IYCDEN--------QIKQVFINLIKNAIEA-----MPNGGT---ITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFF 452

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1376943971 318 TTAKSpleesrhmqetpnvmaGYGYGLPISRLYARYFGGDLQVISMEGYGT 368
Cdd:COG5805   453 TTKEK----------------GTGLGLMVSYKIIENHNGTIDIDSKVGKGT 487
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 253-367 2.22e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 48.61  E-value: 2.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 253 LHQMLFELLKNSLRAVqerfmdSDQESPPIRIIVADGVEDVTVKISDEGGGIPRSGLSKIWTYLYTTAKspleesrhmqe 332
Cdd:cd16976     1 IQQVLMNLLQNALDAM------GKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKP----------- 63

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1376943971 333 tpnVMAGYGYGLPISRLYARYFGGDLQVISMEGYG 367
Cdd:cd16976    64 ---VGKGTGLGLSISYGIVEEHGGRLSVANEEGAG 95
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
207-374 3.60e-07

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 51.86  E-value: 3.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 207 TRVSPVLIAQNAIDDARSAC------MRTYGSAPEVHVYGDPNfafayvptHLHQMLFELLKNSLRavqerFMDSDQEsp 280
Cdd:COG5002   238 EPVDLAELLEEVVEELRPLAeekgieLELDLPEDPLLVLGDPD--------RLEQVLTNLLDNAIK-----YTPEGGT-- 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 281 pIRIIVADGVEDVTVKISDEGGGIPRSGLSKIWTYLYTTAKSpleESRHMQetpnvmaGYGYGLPISRLYARYFGGDLQV 360
Cdd:COG5002   303 -ITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKS---RSRETG-------GTGLGLAIVKHIVEAHGGRIWV 371

                         170
                  ....*....|....
gi 1376943971 361 ISMEGYGTDAYLHL 374
Cdd:COG5002   372 ESEPGKGTTFTITL 385
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 253-368 5.11e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 44.69  E-value: 5.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 253 LHQMLFELLKNSLRAVQERFMDSDQESppIRIIVADGVEdVTVKISDEGGGIPRSGLSKIWTYLYTTAKSpleesrhmqe 332
Cdd:cd16920     1 IQQVLINLVRNGIEAMSEGGCERRELT--IRTSPADDRA-VTISVKDTGPGIAEEVAGQLFDPFYTTKSE---------- 67

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1376943971 333 tpnvmaGYGYGLPISRLYARYFGGDLQVISMEGYGT 368
Cdd:cd16920    68 ------GLGMGLSICRSIIEAHGGRLSVESPAGGGA 97
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 250-368 1.81e-05

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 46.86  E-value: 1.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 250 PTHLHQMLFELLKNSLRAVQerfmdsdQESPPIRIIvADGVEDVTVKISDEGGGIPRSGLSKIWTYLYTTAKSPleESRH 329
Cdd:PRK11091  396 GTRLRQILWNLISNAVKFTQ-------QGGVTVRVR-YEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSH--GGKP 465

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1376943971 330 mqetpnvMAGYGYGLPISRLYARYFGGDLQVISMEGYGT 368
Cdd:PRK11091  466 -------ATGTGIGLAVSKRLAQAMGGDITVTSEEGKGS 497
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 251-367 7.98e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 41.37  E-value: 7.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 251 THLHQMLFELLKNSLRAVQERFMDSdqesPPIRIIV-ADGVEDVTVKISDEGGGIPRSGLSKIwTYLYTTAKSpleesrh 329
Cdd:cd16944     3 TQISQVLTNILKNAAEAIEGRPSDV----GEVRIRVeADQDGRIVLIVCDNGKGFPREMRHRA-TEPYVTTRP------- 70

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1376943971 330 mqetpnvmAGYGYGLPISRLYARYFGGDLQVISMEGYG 367
Cdd:cd16944    71 --------KGTGLGLAIVKKIMEEHGGRISLSNREAGG 100
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
250-382 9.00e-05

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 44.57  E-value: 9.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 250 PTHLHQMLFELLKNSLRAVQERfmdsdqesppIRIIVADGVE---DVTVKISDEGGGIPRSGLSKIWTYLYTTAKSplee 326
Cdd:PRK11360  498 PELLKQVLLNILINAVQAISAR----------GKIRIRTWQYsdgQVAVSIEDNGCGIDPELLKKIFDPFFTTKAK---- 563

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1376943971 327 srhmqetpnvmaGYGYGLPISRLYARYFGGDLQVISMEGYGTDAYLHLNRLGNEQE 382
Cdd:PRK11360  564 ------------GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQGNQ 607
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 260-368 1.31e-04

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 43.68  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 260 LLKNSLRAVQErfmdSDQESPPIRIIVADGVEDVTVKISDEGGGIPRSGLSKIWTYLYTTaksPLEESRhmqetpnvmag 339
Cdd:COG3290   289 LLDNAIEAVEK----LPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFST---KLGEGR----------- 350

                          90       100
                  ....*....|....*....|....*....
gi 1376943971 340 yGYGLPISRLYARYFGGDLQVISMEGYGT 368
Cdd:COG3290   351 -GLGLALVKQIVEKYGGTIEVESEEGEGT 378
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 250-362 2.43e-04

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 43.14  E-value: 2.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 250 PTHLHQMLFELLKNSLRAVQERfmdsdqesPPIRIIVADGVEDVTVKISDEGGGIPRSGlsKIWTYLYTTaKSpleesrh 329
Cdd:COG4192   541 QVLLEQVLVNLLVNALDAVATQ--------PQISVDLLSNAENLRVAISDNGNGWPLVD--KLFTPFTTT-KE------- 602

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1376943971 330 mqetpnvmAGYGYGLPISRLYARYFGGDLQVIS 362
Cdd:COG4192   603 --------VGLGLGLSICRSIMQQFGGDLYLAS 627
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 232-378 2.84e-04

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 42.91  E-value: 2.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 232 SAPEVHVYGDPNFafayvpthLHQMLFELLKNSLRavqerFmdsdqeSPP---IRIIVADGVEDVTVKISDEGGGIPRSG 308
Cdd:PRK11100  356 RPDDARVLGDPFL--------LRQALGNLLDNAID-----F------SPEggtITLSAEVDGEQVALSVEDQGPGIPDYA 416

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 309 LSKIWTYLYTTAKSPLEESrhmqetpnvmaGYGYGLPISRLYARYFGGDLQVISMEGYGTDAYLHLNRLG 378
Cdd:PRK11100  417 LPRIFERFYSLPRPANGRK-----------STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRHF 475
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 250-374 3.28e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 39.75  E-value: 3.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 250 PTHLHQMLFELLKNSLravqerfmDSDQESPPIRIIVADGVEDVTVKISDEGGGIPRSGLSKIWTYLYTTAKSpleesrH 329
Cdd:cd16945     2 PFLLRQAINNLLDNAI--------DFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRP------H 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1376943971 330 MQETPNvmagyGYGLPISRLYARYFGGDLQVISMEGyGTDAYLHL 374
Cdd:cd16945    68 SGQKST-----GLGLAFVQEVAQLHGGRITLRNRPD-GVLAFLTL 106
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
238-374 1.01e-03

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 40.99  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 238 VYGDPNfafayvptHLHQMLFELLKNSLRAVQER-------FMDSDQESPPIRiiVADGVEdvtVKISDEGGGIPRSGLS 310
Cdd:COG3852   238 VLGDPD--------QLIQVLLNLVRNAAEAMPEGgtitirtRVERQVTLGGLR--PRLYVR---IEVIDNGPGIPEEILD 304

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1376943971 311 KIWTYLYTTAKSpleesrhmqetpnvmaGYGYGLPISRLYARYFGGDLQVISMEGYGTDAYLHL 374
Cdd:COG3852   305 RIFEPFFTTKEK----------------GTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYL 352
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 260-368 1.36e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 38.04  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 260 LLKNSLRAVQerfmDSDQESPPIRIIVADGVEDVTVKISDEGGGIPRSGLSKIWTYLYTTAksplEESRHmqetpnvmag 339
Cdd:cd16915     8 LIDNALDALA----ATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTK----GQGER---------- 69

                          90       100
                  ....*....|....*....|....*....
gi 1376943971 340 yGYGLPISRLYARYFGGDLQVISMEGYGT 368
Cdd:cd16915    70 -GIGLALVRQSVERLGGSITVESEPGGGT 97
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 293-362 3.13e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 37.49  E-value: 3.13e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376943971 293 VTVKISDEGGGIPRSGLSKIWTYLYTtakspLEESRHmqetpNVMAGYGYGLPISRLYARYFGGDLQVIS 362
Cdd:cd16947    53 VYIDIWDKGKGISETEKDHVFERLYT-----LEDSRN-----SAKQGNGLGLTITKRLAESMGGSIYVNS 112
PTZ00109 PTZ00109
DNA gyrase subunit b; Provisional
 253-321 3.87e-03

DNA gyrase subunit b; Provisional


Pssm-ID: 240272 [Multi-domain]  Cd Length: 903  Bit Score: 39.48  E-value: 3.87e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1376943971 253 LHQMLFELLKNSlraVQERfmdSDQESPPIRIIVadgVEDVTVKISDEGGGIP--------RSGLSKIWTYLYTTAK 321
Cdd:PTZ00109  130 LHQLLFEILDNS---VDEY---LAGECNKITVVL---HKDGSVEISDNGRGIPcdvsektgKSGLETVLTVLHSGGK 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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