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Conserved domains on  [gi|302756467|ref|XP_002961657|]
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sugar transporter ERD6-like 4 [Selaginella moellendorffii]

Protein Classification

sugar porter family MFS transporter( domain architecture ID 13024188)

sugar porter family major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of sugar or polyol substrates such as glucose, galactose, trehalose, and arabinose, among others

CATH:  1.20.1250.20
SCOP:  3000310
TCDB:  2.A.1.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
46-479 1.86e-175

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 499.79  E-value: 1.86e-175
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  46 VFCTIVVALGPITFGFSVGYSSPTQQKLTED----LGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIP 121
Cdd:cd17358    1 LLATFVANLGSFSFGIAVGWSSPALPSLMSDnslsLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 122 HIAGWILNALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSYLGGLVLPWRTLAL 201
Cdd:cd17358   81 CILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLPWRTLAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 202 VGVAPCSVLLVGLFFIPESPRWLAKMGIEDTLITSLQALRGKDSDISSEVSEIKDAVDISYKQEANVRMSDLCKKTIFLP 281
Cdd:cd17358  161 IGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLRGKDADISKEAAEIQEELAELEKEAKESSFSDLFQRKYLKP 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 282 LTITIGLLLLQQISGINAILFYSSAIFHSAG-FSSSNLASLSLALLQVVMTGVAAVLMDRAGRRLLLMVSGAGMAVSCFL 360
Cdd:cd17358  241 LVIGLGLMLFQQLSGINAVIFYASSIFDEAGsGLDPNTATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGLLA 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 361 VGFAFYLQQHmdatSHFAPFVGNLALISLLVYITSFALGMGPIPWIIMSEVLPAHIKGLGGSVATLVNWTFSWLVTMSFN 440
Cdd:cd17358  321 LGLYFYLQEH----GALLSSVSWLPLVGLVIYIISFSIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFP 396
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 302756467 441 FL-LNWSSTGSFALFAGMCAFTVLFVAVLVPETRGRTLEE 479
Cdd:cd17358  397 FLtLAWGASGTFWIFAGICGLALVFVLLFVPETKGKSLEE 436
 
Name Accession Description Interval E-value
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
46-479 1.86e-175

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 499.79  E-value: 1.86e-175
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  46 VFCTIVVALGPITFGFSVGYSSPTQQKLTED----LGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIP 121
Cdd:cd17358    1 LLATFVANLGSFSFGIAVGWSSPALPSLMSDnslsLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 122 HIAGWILNALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSYLGGLVLPWRTLAL 201
Cdd:cd17358   81 CILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLPWRTLAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 202 VGVAPCSVLLVGLFFIPESPRWLAKMGIEDTLITSLQALRGKDSDISSEVSEIKDAVDISYKQEANVRMSDLCKKTIFLP 281
Cdd:cd17358  161 IGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLRGKDADISKEAAEIQEELAELEKEAKESSFSDLFQRKYLKP 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 282 LTITIGLLLLQQISGINAILFYSSAIFHSAG-FSSSNLASLSLALLQVVMTGVAAVLMDRAGRRLLLMVSGAGMAVSCFL 360
Cdd:cd17358  241 LVIGLGLMLFQQLSGINAVIFYASSIFDEAGsGLDPNTATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGLLA 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 361 VGFAFYLQQHmdatSHFAPFVGNLALISLLVYITSFALGMGPIPWIIMSEVLPAHIKGLGGSVATLVNWTFSWLVTMSFN 440
Cdd:cd17358  321 LGLYFYLQEH----GALLSSVSWLPLVGLVIYIISFSIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFP 396
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 302756467 441 FL-LNWSSTGSFALFAGMCAFTVLFVAVLVPETRGRTLEE 479
Cdd:cd17358  397 FLtLAWGASGTFWIFAGICGLALVFVLLFVPETKGKSLEE 436
Sugar_tr pfam00083
Sugar (and other) transporter;
48-484 2.09e-87

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 275.30  E-value: 2.09e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467   48 CTIVVALGPITFGFSVGYSS-----------PTQQKLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALV 116
Cdd:pfam00083   1 VALVAALGGFLFGYDTGVIGafltlidffknFGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  117 IASIPHIAGWILNALAMNVASLY---IARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSYLGGLV 193
Cdd:pfam00083  81 IANVLFVIGAVLQGAAKGKWSVYqliVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  194 L-------PWRTLALVGVAPCSVLLVGLFFIPESPRWLAKMGIEDTLITSLQALRGkDSDISSEVSEIKDAVDISYKQEA 266
Cdd:pfam00083 161 LnktsnsdGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRG-VPDVDRELDEIKDSLEAGQEAEK 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  267 NVRMSDLCKKTIFLPLTITIGLLLLQQISGINAILFYSSAIFHSAGFSSSNLASLSLALLQVVMTGVAAVLMDRAGRRLL 346
Cdd:pfam00083 240 ASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPL 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  347 LMVSGAGMAVSCFLVGFAFYLQQHMDatshfaPFVGNLALISLLVYITSFALGMGPIPWIIMSEVLPAHIKGLGGSVATL 426
Cdd:pfam00083 320 LLLGAAGMAICFVILGIVALLGVSKS------DWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATA 393
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 302756467  427 VNWTFSWLVTMSFNFLLNWSSTG-SFALFAGMCAFTVLFVAVLVPETRGRTLEEIEALF 484
Cdd:pfam00083 394 ANWLANFLIGFLFPIITDAIGLGyTFFIFAGLLVLFIIFVFFFVPETKGRTLEEIDELF 452
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
44-480 1.15e-82

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 263.82  E-value: 1.15e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467   44 YTVFCTIVVALGPITFGFSVGYSS------PTQQKLTEDL--GLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGAL 115
Cdd:TIGR00879  25 KVALLSLIAAIGGLMFGYDTGVIGgalalpAFEFKFTSANsdSYSSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSL 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  116 VIASIPHIAGWILNAL---AMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSY---- 188
Cdd:TIGR00879 105 LIIALLFVIGAILMGLaafALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYgfgs 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  189 ---LGGLVLPWRTLALVGVAPCSVLLVGLFFIPESPRWLAKMGIEDTLITSLQALRGkDSDISSEVSEIKDAVDISYKQE 265
Cdd:TIGR00879 185 gkvSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRG-TSGEDKELLDELELIDIKRSIE 263
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  266 ANVRMSDL-----CKKTIFLPLTITIGLLLLQQISGINAILFYSSAIFHSAGFSSSNLASLSLALLQVVM--TGVAAVLM 338
Cdd:TIGR00879 264 KRSVQPSWgslfsSTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTDHAFLVSIIVGAVNFafTFVAIFLV 343
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  339 DRAGRRLLLMVSGAGMAVSCFLVGFAFYLQQHMDATShfapfVGNLALISLLVYITSFALGMGPIPWIIMSEVLPAHIKG 418
Cdd:TIGR00879 344 DRFGRRPLLLIGAAGMAICLFVLGILGASFVTGSSKS-----SGNVAIVFILLFIAFFAMGWGPVPWVIVSEIFPLSLRP 418
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 302756467  419 LGGSVATLVNWTFSWLVTMSFNFLLNWSSTG-SFALFAGMCAFTVLFVAVLVPETRGRTLEEI 480
Cdd:TIGR00879 419 KGISIAVAANWLANFIVGFLFPTMLESIGVGgVFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
xylE PRK10077
D-xylose transporter XylE; Provisional
40-486 1.19e-57

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 197.99  E-value: 1.19e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  40 GSVLYTVFCTIVVALGPITFGFSVGYSSPTQ----------QKLTEDLGLSLSEFSMYGSLVnaGAMAGAILSGRIADRF 109
Cdd:PRK10077   5 YNSSYIFSITLVATLGGLLFGYDTAVISGTVeslntvfvapQNLSESAANSLLGFCVASALI--GCIIGGALGGYCSNRF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 110 GRKGALVIASI-----------PHIAGWILNALAMN-VASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQ 177
Cdd:PRK10077  83 GRRDSLKIAAVlffisalgsawPEFGFTSIGPDNTGyVPEFVIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQ 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 178 LSVTTGIFLSY------LGGLVLP------WRTLALVGVAPCSVLLVGLFFIPESPRWLAKMGIEDTLITSLQALRGKdS 245
Cdd:PRK10077 163 FAIIFGQLVVYfvnyfiARSGDASwlntdgWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGN-T 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 246 DISSEVSEIKDAvdISYKQEANVRMSDLCKKTIFLpltiTIGLLLLQQISGINAILFYSSAIFHSAGFSSSNLASLSLA- 324
Cdd:PRK10077 242 LATQALQEIKHS--LDHGRKTGGKLLMFGVGVIVI----GVMLSVFQQFVGINVVLYYAPEIFKTLGASTDIALLQTIIv 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 325 -LLQVVMTGVAAVLMDRAGRRLLLMVSGAGMAVSCFLVGFAFYLQqhmdatshfapFVGNLALISLLVYITSFALGMGPI 403
Cdd:PRK10077 316 gVINLTFTVLAIMTVDKFGRKPLQIIGALGMAIGMFSLGTAFYTQ-----------APGIVALLSMLFYVAAFAMSWGPV 384
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 404 PWIIMSEVLPAHIKGLGGSVATLVNWTFSWLVTMSFNFLLNWSSTG-------SFALFAGMCAFTVLFVAVLVPETRGRT 476
Cdd:PRK10077 385 CWVLLSEIFPNAIRGKALAIAVAAQWIANYFVSWTFPMMDKNSWLVahfhngfSYWIYGCMGVLAALFMWKFVPETKGKT 464
                        490
                 ....*....|
gi 302756467 477 LEEIEALFQE 486
Cdd:PRK10077 465 LEEMEALWEP 474
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
50-432 2.57e-19

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 88.88  E-value: 2.57e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  50 IVVALGPITFGFSVGYSSPTQQKLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILN 129
Cdd:COG2814   13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 130 ALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSYLGGLVL----PWRTLALVGVA 205
Cdd:COG2814   93 ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLadlfGWRWVFLVNAV 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 206 PCSV-LLVGLFFIPESPRwlakmgiedtlitslqalrgkdsdissevseikdavdiSYKQEANVRMSDLCKKTIFLPLTI 284
Cdd:COG2814  173 LALLaLLLLLRLLPESRP--------------------------------------AARARLRGSLRELLRRPRLLLLLL 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 285 TIGLLLLQQISGINAILFYSSAIFHsAGFSSSNLASLSLALLQVVMTGVAAVLMDRAGRRLLLMVSGAGMAVSCFLVGFA 364
Cdd:COG2814  215 LAFLLGFGFFALFTYLPLYLQEVLG-LSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALA 293
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 302756467 365 fylqqhmdatshfapfvGNLALISLLVYITSFALGM-GPIPWIIMSEVLPAHIKGLGGSVATLVNWTFS 432
Cdd:COG2814  294 -----------------GSLWLLLLALFLLGFGFGLlFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
 
Name Accession Description Interval E-value
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
46-479 1.86e-175

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 499.79  E-value: 1.86e-175
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  46 VFCTIVVALGPITFGFSVGYSSPTQQKLTED----LGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIP 121
Cdd:cd17358    1 LLATFVANLGSFSFGIAVGWSSPALPSLMSDnslsLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 122 HIAGWILNALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSYLGGLVLPWRTLAL 201
Cdd:cd17358   81 CILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLPWRTLAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 202 VGVAPCSVLLVGLFFIPESPRWLAKMGIEDTLITSLQALRGKDSDISSEVSEIKDAVDISYKQEANVRMSDLCKKTIFLP 281
Cdd:cd17358  161 IGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLRGKDADISKEAAEIQEELAELEKEAKESSFSDLFQRKYLKP 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 282 LTITIGLLLLQQISGINAILFYSSAIFHSAG-FSSSNLASLSLALLQVVMTGVAAVLMDRAGRRLLLMVSGAGMAVSCFL 360
Cdd:cd17358  241 LVIGLGLMLFQQLSGINAVIFYASSIFDEAGsGLDPNTATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGLLA 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 361 VGFAFYLQQHmdatSHFAPFVGNLALISLLVYITSFALGMGPIPWIIMSEVLPAHIKGLGGSVATLVNWTFSWLVTMSFN 440
Cdd:cd17358  321 LGLYFYLQEH----GALLSSVSWLPLVGLVIYIISFSIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFP 396
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 302756467 441 FL-LNWSSTGSFALFAGMCAFTVLFVAVLVPETRGRTLEE 479
Cdd:cd17358  397 FLtLAWGASGTFWIFAGICGLALVFVLLFVPETKGKSLEE 436
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
49-479 5.81e-100

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 306.42  E-value: 5.81e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  49 TIVVALGPITFGFSVGYSSPTQQKLTE----DLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIA 124
Cdd:cd17433    4 TFAAVLGPLSFGFVLGYSSPAIPSLQRiadpALRLDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVPFIA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 125 GWILNALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSYLGGLVLPWRTLALVGV 204
Cdd:cd17433   84 GFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLGSCVQLMVVIGIMGAYLAGLVLDWRWLAVLGS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 205 APCSVLLVGLFFIPESPRWLAKMGIEDTLITSLQALRGKDSDISSEVSEIKDAvdiSYKQEANVRMSDLCKKTIFLPLTI 284
Cdd:cd17433  164 IPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLRGPDQGWEWECIGIEQS---FHLEEQSFSLALLKQPGIYKPLII 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 285 TIGLLLLQQISGINAILFYSSAIFHSAGFSSSNLASLSLALLQVVMTGVAAVLMDRAGRRLLLMVSGAGMAVScflvgfa 364
Cdd:cd17433  241 GVSLMAFQQLTGINAVMFYAETIFEEAKFKDSSVASVIVAAIQVLFTAVAALIMDRAGRKVLLVLSGVVMVFS------- 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 365 fylqqhmdaTSHFapfvGNLALISLLVYITSFALGMGPIPWIIMSEVLPAHIKGLGGSVATLVNWTFSWLVTMSFNFLLN 444
Cdd:cd17433  314 ---------TAAF----GWLAVGSMGFFIAGFAVGWGPIPWLVMSEIFPLHVRGVASGICVLTNWLMAFLVTKEFSSLME 380
                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 302756467 445 -WSSTGSFALFAGMCAFTVLFVAVLVPETRGRTLEE 479
Cdd:cd17433  381 vLSSYGTFWLFSAFCAFSVLFTLFCVPETKGKTLEQ 416
Sugar_tr pfam00083
Sugar (and other) transporter;
48-484 2.09e-87

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 275.30  E-value: 2.09e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467   48 CTIVVALGPITFGFSVGYSS-----------PTQQKLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALV 116
Cdd:pfam00083   1 VALVAALGGFLFGYDTGVIGafltlidffknFGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  117 IASIPHIAGWILNALAMNVASLY---IARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSYLGGLV 193
Cdd:pfam00083  81 IANVLFVIGAVLQGAAKGKWSVYqliVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  194 L-------PWRTLALVGVAPCSVLLVGLFFIPESPRWLAKMGIEDTLITSLQALRGkDSDISSEVSEIKDAVDISYKQEA 266
Cdd:pfam00083 161 LnktsnsdGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRG-VPDVDRELDEIKDSLEAGQEAEK 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  267 NVRMSDLCKKTIFLPLTITIGLLLLQQISGINAILFYSSAIFHSAGFSSSNLASLSLALLQVVMTGVAAVLMDRAGRRLL 346
Cdd:pfam00083 240 ASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPL 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  347 LMVSGAGMAVSCFLVGFAFYLQQHMDatshfaPFVGNLALISLLVYITSFALGMGPIPWIIMSEVLPAHIKGLGGSVATL 426
Cdd:pfam00083 320 LLLGAAGMAICFVILGIVALLGVSKS------DWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATA 393
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 302756467  427 VNWTFSWLVTMSFNFLLNWSSTG-SFALFAGMCAFTVLFVAVLVPETRGRTLEEIEALF 484
Cdd:pfam00083 394 ANWLANFLIGFLFPIITDAIGLGyTFFIFAGLLVLFIIFVFFFVPETKGRTLEEIDELF 452
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
44-480 1.15e-82

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 263.82  E-value: 1.15e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467   44 YTVFCTIVVALGPITFGFSVGYSS------PTQQKLTEDL--GLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGAL 115
Cdd:TIGR00879  25 KVALLSLIAAIGGLMFGYDTGVIGgalalpAFEFKFTSANsdSYSSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSL 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  116 VIASIPHIAGWILNAL---AMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSY---- 188
Cdd:TIGR00879 105 LIIALLFVIGAILMGLaafALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYgfgs 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  189 ---LGGLVLPWRTLALVGVAPCSVLLVGLFFIPESPRWLAKMGIEDTLITSLQALRGkDSDISSEVSEIKDAVDISYKQE 265
Cdd:TIGR00879 185 gkvSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRG-TSGEDKELLDELELIDIKRSIE 263
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  266 ANVRMSDL-----CKKTIFLPLTITIGLLLLQQISGINAILFYSSAIFHSAGFSSSNLASLSLALLQVVM--TGVAAVLM 338
Cdd:TIGR00879 264 KRSVQPSWgslfsSTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTDHAFLVSIIVGAVNFafTFVAIFLV 343
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  339 DRAGRRLLLMVSGAGMAVSCFLVGFAFYLQQHMDATShfapfVGNLALISLLVYITSFALGMGPIPWIIMSEVLPAHIKG 418
Cdd:TIGR00879 344 DRFGRRPLLLIGAAGMAICLFVLGILGASFVTGSSKS-----SGNVAIVFILLFIAFFAMGWGPVPWVIVSEIFPLSLRP 418
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 302756467  419 LGGSVATLVNWTFSWLVTMSFNFLLNWSSTG-SFALFAGMCAFTVLFVAVLVPETRGRTLEEI 480
Cdd:TIGR00879 419 KGISIAVAANWLANFIVGFLFPTMLESIGVGgVFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
51-471 1.50e-81

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 257.12  E-value: 1.50e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  51 VVALGPITFGFSVGYSSPTQQKLTEDLGLSLSEF--SMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWIL 128
Cdd:cd17315    1 VAALGGLLFGYDLGVINGALLYIAKDLGFGLSTSlqGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 129 NALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSYLGGLVLP------WRTLALV 202
Cdd:cd17315   81 SALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSlsppgwWRLMFAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 203 GVAPCSVLLVGLFFIPESPRWLAKMGiedtlitsLQALrgkdsdissevseikdavdisykqeanvrmsdlckktiflpl 282
Cdd:cd17315  161 AAVPALLQLLLMFFLPESRALLVGVG--------LQLL------------------------------------------ 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 283 titigllllQQISGINAILFYSSAIFHSAG-FSSSNLASLSLALLQVVMTGVAAVLMDRAGRRLLLMVSGAGMAVSCFLV 361
Cdd:cd17315  191 ---------QQLTGINAVMYYAPTIFKSAGgGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLLIGFAGMAASLLLL 261
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 362 GFAFYLqqhmdatSHFAPFVGNLALISLLVYITSFALGMGPIPWIIMSEVLPAHIKGLGGSVATLVNWTFSWLVTMSFNF 441
Cdd:cd17315  262 AIAFLL-------PALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLI 334
                        410       420       430
                 ....*....|....*....|....*....|.
gi 302756467 442 LLN-WSSTGSFALFAGMCAFTVLFVAVLVPE 471
Cdd:cd17315  335 MVStIGLAGVFIFFAAVCLLALVFVFFFVPE 365
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
48-475 2.82e-74

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 241.01  E-value: 2.82e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  48 CTIVVALGPITFGFSVGYSSPTQQKLTE----------DLGLSLSEFSMYGSLVNA----GAMAGAILSGRIADRFGRKG 113
Cdd:cd17357    1 AVIVAFGGSFQFGYNIGVVNAPQEVFKEfindtlvdryGLNLSDSELDLLWSLIVSiffiGGAIGSFISAFLANRFGRKN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 114 ALVIASIPHIAGWILNALAMNVAS---LYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLS--- 187
Cdd:cd17357   81 GLLISNALLVVSSLLMFLSKSAKSpelLIFGRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILLGqvf 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 188 ---YLGGLVLPWRTLALVGVAPCSVLLVGLFFIPESPRWLA-KMGIEDTLITSLQALRGKDSDISSEVSEIKDAVDISYK 263
Cdd:cd17357  161 glpSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLiSKGDEEEAEKSLKFLRGIEDDVDQELEEIKKESEQMGD 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 264 QEANVRMSDLCKKTIFLPLTITIGLLLLQQISGINAILFYSSAIFHSAGFSSSNLAS--LSLALLQVVMTGVAAVLMDRA 341
Cdd:cd17357  241 QKQVSLMQLLRDPSLRLPLLLVLVVSASQQFSGINAIFFYSTFIFENAGFSPQLAEWanLGIGIVNVLSTIVGPFLIEKV 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 342 GRRLLLMVSGAGMAVSCFLVGFAFYLQqhmdatsHFAPFVGNLALISLLVYITSFALGMGPIPWIIMSEVLPAHIKGLGG 421
Cdd:cd17357  321 GRRPLLLISLSVCAVALLLMSVFLFLS-------EQNSWMSYGCIVAIFLFIFFFAIGLGPIPWFIGAELFPQAPRSAAQ 393
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 302756467 422 SVATLVNWTFSWLVTMSFNFLLNWSSTGSFALFAGMCAFTVLFVAVLVPETRGR 475
Cdd:cd17357  394 SLGSSVNWTSNFIVGMAFPPLQSIGGGFVFIIFAIPCALFLLYLYRYLPETKGR 447
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
49-471 1.40e-73

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 237.08  E-value: 1.40e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  49 TIVVALGPITFGFSVGYSSPTQQKLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWIL 128
Cdd:cd17359    3 SLVAALGGLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 129 NALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSYLGGLVLP------------W 196
Cdd:cd17359   83 SAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIAnaggadwlgaegW 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 197 RTLALVGVAPCSVLLVGLFFIPESPRWLAKMGiedtlitslqalrgkdsdissevseikdavdisykqeanvrmsdlcKK 276
Cdd:cd17359  163 RWMLGLEAIPAILFLLGMLFIPESPRWLVSKG----------------------------------------------KP 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 277 TIFLpltiTIGLLLLQQISGINAILFYSSAIFHSAGFSSSNLASLSLA--LLQVVMTGVAAVLMDRAGRRLLLMVSGAGM 354
Cdd:cd17359  197 ILII----GIGLAIFQQFVGINVIFYYGPEIFQNAGFSENAALLQTIGigVVNVIFTIIAILLVDKVGRKPLLLIGSIGM 272
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 355 AVSCFLVGFAFYLQQHMDATshfapfvGNLALISLLVYITSFALGMGPIPWIIMSEVLPAHIKGLGGSVATLVNWTFSWL 434
Cdd:cd17359  273 AISLLLIGTAFYFAPGSQAS-------GIVALVLILLFVAFFAMSWGPVTWVLLSEIFPNRIRGLAMGIAVFFLWIANFL 345
                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 302756467 435 VTMSFNFLLN-WSSTGSFALFAGMCAFTVLFVAVLVPE 471
Cdd:cd17359  346 VSLTFPILLAaFGLAFTFLIFAVICVLAFLFVWKFVPE 383
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
54-479 2.36e-69

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 227.41  E-value: 2.36e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  54 LGPITFGFSVGYSSPT----QQKLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILN 129
Cdd:cd17434    9 LGNFSFGYALVYTSPVipalEQGDDPRLHLNVHQISWFGSVFTLGAAAGGLSAMFLNDRLGRKLSIMFSAVPSALGYLLM 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 130 ALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSYLGGLVLPWRTLALVGVAPCSV 209
Cdd:cd17434   89 GSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISHPGVRGALGACPQIMAVFGSLALYALGLLLPWRWLAVAGEVPVVI 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 210 LLVGLFFIPESPRWLAKMGIEDTLITSLQALRGKDSDISSEVSEIKDAVdisYKQEANVRMSDLCKKTIFLPLTITIGLL 289
Cdd:cd17434  169 MILLLCFMPNSPRFLISKGKDEKALKALAWLRGPNTDYMTEFEQIKDNI---RKQSSRLSWAELKTPSYYKPILIAVVMR 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 290 LLQQISGINAILFYSSAIFHSAGFSSSNLA-SLSLALLQVVMTGVAAVLMDRAGRRLLLMVSGAGMAVSCFLVGFafylq 368
Cdd:cd17434  246 FLQQLTGITPILVYLEPIFHLTAVILEPKYdAALVGAVRLLSVAIAASLMDKAGRKILLFTSAFLMFAANLSMGL----- 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 369 qhmdatshfapfvgnLALISLLVYITSFALGMGPIPWIIMSEVLPAHIKGLGGSVATLVNWTFSWLVTMSFNFLLN-WSS 447
Cdd:cd17434  321 ---------------IPLIAAMLFIMGYAMGWGPITWLLMSEILPLKARGVASGLCVVVSWITAFVLTQLFLPVVVtFGL 385
                        410       420       430
                 ....*....|....*....|....*....|..
gi 302756467 448 TGSFALFAGMCAFTVLFVAVLVPETRGRTLEE 479
Cdd:cd17434  386 QVPFLFFAAVCAVSIIFTACCVPETKGRTLEQ 417
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
53-471 1.01e-66

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 218.68  E-value: 1.01e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  53 ALGPITFGFSVGYSSPTQQKLTEDLGLSLSEFSMYGSLVN---AGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILN 129
Cdd:cd17360    3 GIGGFLFGYDTGVISGALLYIKDDLGEVVLSTGWQELIVSstvAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 130 ALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSYLGGLVLP-----WRTLALVGV 204
Cdd:cd17360   83 AAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSylpggWRWMLGLAA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 205 APCSVLLVGLFFIPESPRWlakmgiedtlitslqalrgkdsdissevseikdavdisykqeanvrmsdlckKTIFLPLTI 284
Cdd:cd17360  163 VPAVLQFIGLLFLPESPRW----------------------------------------------------PSTRRALIV 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 285 TIGLLLLQQISGINAILFYSSAIFHSAGF---SSSNLASLSLALLQVVMTGVAAVLMDRAGRRLLLMVSGAGMAVSCFLV 361
Cdd:cd17360  191 GCGLQAFQQFSGINTVMYYSATILQMAGFkdnQNAIWLSLIVAGTNFIFTIVGMYLIDKFGRRKLLLISLFGVIVALVVL 270
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 362 GfafylqqhmdatshfapfvGNLALISLLVYITSFALGMGPIPWIIMSEVLPAHIKGLGGSVATLVNWTFSWLVTMSFNF 441
Cdd:cd17360  271 A-------------------VWLALVGLILYLAFFAPGMGPVPWTVNSEIYPLWARGTGGGCAAAVNWVFNLLVSQTFLT 331
                        410       420       430
                 ....*....|....*....|....*....|.
gi 302756467 442 LLNW-SSTGSFALFAGMCAFTVLFVAVLVPE 471
Cdd:cd17360  332 LTQAiGPYGTFLLFAGLAVLGLIFIYFCVPE 362
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
47-475 1.24e-64

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 215.66  E-value: 1.24e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  47 FCTIVVALGPITFGFSVGY---------------------SSPTQQKLTEDLGLSLSEFSMygslvnaGAMAGAILSGRI 105
Cdd:cd17431    1 FAVFVAVLGSLQFGYNTGVinapqkvieefynktlgdrygEPISPETLTTLWSLSVAIFSV-------GGMIGSFSVGLF 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 106 ADRFGRKGALVIASIPHIAGWILNALAMNVAS---LYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTT 182
Cdd:cd17431   74 VNRFGRRNSMLYNNLLAFAGAALMGLSKLAKSyemLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVV 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 183 GIFLSYLGGLVL------PWRTLALVGVAPCSVLLVGLFFIPESPRWL-AKMGIEDTLITSLQALRGkDSDISSEVSEIK 255
Cdd:cd17431  154 GILISQIFGLEFilgteeLWPLLLGFTIVPAILQLALLPFCPESPRYLlINRNEEEEAKSVLKKLRG-TTDVSEDIQEMK 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 256 DAVDISYKQEANVRMSDLCKKTIFLPLTITIGLLLLQQISGINAILFYSSAIFHSAGFSSSNLASLSLALLQVVMTGVAA 335
Cdd:cd17431  233 EESRQMMREKKVTILELFRSSSYRQPIIIAIVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGAGVVNTIFTVVSL 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 336 VLMDRAGRRLLLMVSGAGMAVSCFLVGFAFYLQQHMDATSHfapfvgnLALISLLVYITSFALGMGPIPWIIMSEVLPAH 415
Cdd:cd17431  313 FLVERAGRRTLHLIGLGGMAICAILMTIALLLLEGYPWMSY-------VSIVAIFGFVAFFEIGPGPIPWFIVAELFSQG 385
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 416 IKGLGGSVATLVNWTFSWLVTMSFNFLLNWSSTGSFALFAGMCAFTVLFVAVLVPETRGR 475
Cdd:cd17431  386 PRPAAMAVAGFSNWTSNFIVGMCFQYIANLCGPYVFIIFTVFLLTFFIFTYFKVPETKGK 445
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
53-480 3.25e-60

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 202.58  E-value: 3.25e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  53 ALGPITFGFSVGYSSPTQQKLTEDL-------GLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAG 125
Cdd:cd17362    3 ALGGLLFGYDIGATSGALLSITSPAlsgtdwyNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 126 WILNALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSYL-----GGLVLPWRTLA 200
Cdd:cd17362   83 SLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVsgyafADVVGGWRYMY 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 201 LVGVAPCSVLLVGLFFIPESPRWLAKMGIEDTLITSLQALrgkdsdissevseikdavdisykqeanvrmsdlckktifl 280
Cdd:cd17362  163 GLAAPPALLLGIGMWFLPPSPRWQGNYRKPLIIGLGLVLF---------------------------------------- 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 281 pltitigllllQQISGINAILFYSSAIFHSAGFSSSNLASLSLA---LLQVVMTGVAAVLMDRAGRRLLLMVSGAGMAVS 357
Cdd:cd17362  203 -----------QQITGQPSVLYYAATIFKSAGFSAASDATLVSVglgVFKLLMTIVAVLLVDKLGRRPLLLGGVSGMVVS 271
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 358 CFLVGfAFYLQQHMDATshfapFVGNLALISLLVYITSFALGMGPIPWIIMSEVLPAHIKGLGGSVATLVNWTFSWLVTM 437
Cdd:cd17362  272 LFLLA-AYNLFVQMGPA-----GLAWLSLVALLLYVGAYQISFGPISWLMVSEIFPLRVRGRAIALAVLVNFGSNALVSL 345
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 302756467 438 SFNFLLNWSST-GSFALFAGMCAFTVLFVAVLVPETRGRTLEEI 480
Cdd:cd17362  346 AFLPLQELIGLpGTFLGFGVIGVLALLFIYFTVPETKGLSLEEI 389
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
47-484 2.90e-59

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 200.17  E-value: 2.90e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  47 FCTIVVALGPITFGFSVGY-----SSPTQQKLTEDL----GLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVI 117
Cdd:cd17356    1 LLCAFVSLGGFLFGYDTGSisgilNMKSFQKYFADNtgtyYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 118 ASIPHIAGWILNALAMNVASLYIA-RLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSY-------- 188
Cdd:cd17356   81 GCVIYIIGAIIQVAAIGKWYQLIVgRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYcinygthk 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 189 LGGLVlPWRTLALVGVAPCSVLLVGLFFIPESPRWLAKMgiedTLITSLQALrgkdsdissevseikdavdisykqeanv 268
Cdd:cd17356  161 LDGSA-QWRIPLGLQIVWGLLLLIGMFFLPESPRWLYRT----ILGIMLQLF---------------------------- 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 269 rmsdlckktiflpltitigllllQQISGINAILFYSSAIFHSAGFSSSN--LASLSLALLQVVMTGVAAVLMDRAGRRLL 346
Cdd:cd17356  208 -----------------------QQLTGINYFFYYGTTIFQSTGLTGSSplLTSIILYIVNFVSTIPGLFFVDKFGRRTC 264
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 347 LMVSGAGMAVSCFLVGF--AFYLQQH--MDATSHFApfvGNLALISLLVYITSFALGMGPIPWIIMSEVLPAHIKGLGGS 422
Cdd:cd17356  265 LLIGAAGMSICLFIYAAvgVRYLIPNpqSGTSNKSA---GNGMIVFICLFIFSFATTWGPIAWVYVAEVFPLRVRSKGMA 341
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 302756467 423 VATLVNWTFSWLVTMSFNFLLNWSSTGSFALFAGMCAFTVLFVAVLVPETRGRTLEEIEALF 484
Cdd:cd17356  342 LATAFNWLWNFLISFFTPFIIGSIGFKYYYIFAGCNLLAFIVVFFFVPETKGLTLEEIDELF 403
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
94-480 3.01e-58

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 198.99  E-value: 3.01e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  94 GAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVAS---LYIARLLVGFGVGVISFTVPMYIAEISPKNLRG 170
Cdd:cd17432   62 GGLFGSLLVGPLVIRLGRKGTLLLNNIFAIVAAILMGLSKIAKSfemIIVGRFLVGINAGISLNVVPMYLGESAPKNLRG 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 171 SLGAINQLSVTTGIFLSYLGGL--VL------PWrTLALVGVaPCSVLLVGLFFIPESPRW-LAKMGIEDTLITSLQALR 241
Cdd:cd17432  142 AVGLVPAIFITLGILLGQVLGLreLLgneegwPL-LLALTGV-PALLQLLTLPFFPESPRYlLIEKGDEEAARKALQRLR 219
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 242 GKDsDISSEVSEIKdAVDISYKQEANVRMSDLCK-KTIFLPLTITIGLLLLQQISGINAILFYSSAIFHSAGFSSSNL-- 318
Cdd:cd17432  220 GKE-DVDDEMEEML-EEQRAEKGVGTVSVLELFRdRSVRWQLISIIVLMAGQQLCGINAIYFYADSIFLEAGIPEDKIqy 297
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 319 ASLSLALLQVVMTGVAAVLMDRAGRRLLLMVSGAGMAVSCFLVGFAFYLQQHmdatshfAPFVGNLALISLLVYITSFAL 398
Cdd:cd17432  298 VTVGTGACEVLATITCVLVIERLGRRPLLIGGFGLMAVWCAVLTVALSLQNT-------VSWMPYLSIVCIFAYIASFGI 370
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 399 GMGPIPWIIMSEVLPAHIKGLGGSVATLVNWTFSWLVTMSFNFLLNWSSTGSFALFAGMCAFTVLFVAVLVPETRGRTLE 478
Cdd:cd17432  371 GPAGVPFILTTEIFDQSSRPAAFMVAGSLNWLSNFLVGLLFPFIQEGLGAYCFLVFAVICLLTAIYIFFVLPETKGKTFL 450

                 ..
gi 302756467 479 EI 480
Cdd:cd17432  451 EI 452
xylE PRK10077
D-xylose transporter XylE; Provisional
40-486 1.19e-57

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 197.99  E-value: 1.19e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  40 GSVLYTVFCTIVVALGPITFGFSVGYSSPTQ----------QKLTEDLGLSLSEFSMYGSLVnaGAMAGAILSGRIADRF 109
Cdd:PRK10077   5 YNSSYIFSITLVATLGGLLFGYDTAVISGTVeslntvfvapQNLSESAANSLLGFCVASALI--GCIIGGALGGYCSNRF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 110 GRKGALVIASI-----------PHIAGWILNALAMN-VASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQ 177
Cdd:PRK10077  83 GRRDSLKIAAVlffisalgsawPEFGFTSIGPDNTGyVPEFVIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQ 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 178 LSVTTGIFLSY------LGGLVLP------WRTLALVGVAPCSVLLVGLFFIPESPRWLAKMGIEDTLITSLQALRGKdS 245
Cdd:PRK10077 163 FAIIFGQLVVYfvnyfiARSGDASwlntdgWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGN-T 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 246 DISSEVSEIKDAvdISYKQEANVRMSDLCKKTIFLpltiTIGLLLLQQISGINAILFYSSAIFHSAGFSSSNLASLSLA- 324
Cdd:PRK10077 242 LATQALQEIKHS--LDHGRKTGGKLLMFGVGVIVI----GVMLSVFQQFVGINVVLYYAPEIFKTLGASTDIALLQTIIv 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 325 -LLQVVMTGVAAVLMDRAGRRLLLMVSGAGMAVSCFLVGFAFYLQqhmdatshfapFVGNLALISLLVYITSFALGMGPI 403
Cdd:PRK10077 316 gVINLTFTVLAIMTVDKFGRKPLQIIGALGMAIGMFSLGTAFYTQ-----------APGIVALLSMLFYVAAFAMSWGPV 384
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 404 PWIIMSEVLPAHIKGLGGSVATLVNWTFSWLVTMSFNFLLNWSSTG-------SFALFAGMCAFTVLFVAVLVPETRGRT 476
Cdd:PRK10077 385 CWVLLSEIFPNAIRGKALAIAVAAQWIANYFVSWTFPMMDKNSWLVahfhngfSYWIYGCMGVLAALFMWKFVPETKGKT 464
                        490
                 ....*....|
gi 302756467 477 LEEIEALFQE 486
Cdd:PRK10077 465 LEEMEALWEP 474
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
51-480 1.40e-54

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 187.61  E-value: 1.40e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  51 VVALGPITFGFSVGYSSPTQQKLTEDLGLS-LSEFSMYGSLvNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILN 129
Cdd:cd17437    1 LASLNSILLGYDIGVMSGAVIFIKEDLKISdVQEEVLIGSL-NIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLM 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 130 ALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSYLGGLV-------LPWRTLALV 202
Cdd:cd17437   80 GVAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYVSNYAfsglplhVGWRLMLGV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 203 GVAPCSVLLVGLFFIPESPRWLAkmGIEDTLITslqalrgkdsdissevseikdAVDISYkqeanvrmsdlckktiflpl 282
Cdd:cd17437  160 GAVPSLFLAIGVLAMPESPRWTP--AVRRMLIA---------------------ALGIHF-------------------- 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 283 titiglllLQQISGINAILFYSSAIFHSAGFSSSNLASLSLALLQVVMTG---VAAVLMDRAGRRLLLMVSGAGMAVSCF 359
Cdd:cd17437  197 --------FQQASGIDAVVLYSPRIFKKAGIKSKDKLLLATVAVGVTKTLfilVATFLLDKVGRRPLLLTSTGGMTLSLT 268
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 360 LVGFAFYLQQHMDATSHFAPFvgnLALISLLVYITSFALGMGPIPWIIMSEVLPAHIKGLGGSVATLVNWTFSWLVTMSF 439
Cdd:cd17437  269 ALATSLTFIDRNGGGLTWALV---LAITAVCSFVAFFSIGAGPITWVYSSEIFPLRLRAQGASLGVVVNRLMSGTVSMTF 345
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 302756467 440 NFLLNWSST-GSFALFAGMCAFTVLFVAVLVPETRGRTLEEI 480
Cdd:cd17437  346 LSMSKAITTgGTFFLFAGVAAAAWVFFYFFLPETKGKSLEEI 387
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
85-471 1.21e-46

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 166.27  E-value: 1.21e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  85 SMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVISFTVPMYIAEIS 164
Cdd:cd17361   54 QLFTSSLYLAGLVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMA 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 165 PKNLRGSLGAINQLSVTTGIF----LSYLGGLVLP--WR-TLALVGVaPCSVLLVGLFFIPESPRwlakmgiEDTLITSL 237
Cdd:cd17361  134 PAKLRGALNIGFQLAITIGILianlINYGTSKIKPngWRlSLGLAAV-PALILLLGSLFLPETPN-------SPQLVIAI 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 238 qalrgkdsdissevseikdavdisykqeanvrmsdlckktiflpltitiGLLLLQQISGINAILFYSSAIFHSAGFSSSN 317
Cdd:cd17361  206 -------------------------------------------------LIPFFQQLTGINVIMFYAPVLFQTLGFGSDA 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 318 --LASLSLALLQVVMTGVAAVLMDRAGRRLLLMVSGAGMAVSCFLVG--FAFYLQQHMDATSHFAPFVgnlaLISLLVYI 393
Cdd:cd17361  237 slISAVITGAVNVVSTLVSIYLVDRFGRRFLLLEGGVQMLASQVAIGilLAVKFGDGGELPKAYAIAV----VVLICLYV 312
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 302756467 394 TSFALGMGPIPWIIMSEVLPAHIKGLGGSVATLVNWTFSWLVTMSFNFLLNWSSTGSFALFAGMCAFTVLFVAVLVPE 471
Cdd:cd17361  313 AAFAWSWGPLGWLVPSEIFPLETRSAGQSLTVAVNFLFTFVIAQAFLSMLCAMKFGIFLFFAGWVVVMSLFVYFLLPE 390
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
49-480 1.80e-34

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 133.00  E-value: 1.80e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  49 TIVVALGPITFGFSVGYSSPTQQKLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWIL 128
Cdd:cd17435    3 SVTAAVSGLLVGYELGIISGALLQLRTLLALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 129 NALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSYL-----GGLVLPWRTLALVG 203
Cdd:cd17435   83 LVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYIsnyafANVSNGWKYMFGLV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 204 VAPCSVLLVGLFFIPESPRWLAkmgiedtlitslqalrgkdsdissevseIKDavdisykqeaNVRMSDLCKKTIFLplt 283
Cdd:cd17435  163 IPLAALQAIAMYFLPPSPRFLV----------------------------MKD----------NMRARLLIGLTLVF--- 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 284 itiglllLQQISGINAILFYSSAIFHSAGFSSSNLASLSLA---LLQVVMTGVAAVLMDRAGRRLLLMVSGAGMAVSCFL 360
Cdd:cd17435  202 -------FVQITGQPNILFYASTVLKSVGFQSNEAASLASTgvgVVKVVSTIPAIFLVDKVGSKTFLCIGSSVMAVSLVT 274
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 361 VGFAfylqqhmdatshfapfvgnLALISLLVYITSFALGMGPIPWIIMSEVLPAHIKGLGGSVATLVNWTFSWLVTMSFN 440
Cdd:cd17435  275 MGLW-------------------LSLASLLVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFL 335
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*
gi 302756467 441 FL-----LNWSSTGsfalFAGMCAFTVLFVAVLVPETRGRTLEEI 480
Cdd:cd17435  336 TVteligLPWVCFI----YTAMSLASLVFVIMFVPETKGCSLEQI 376
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
48-480 2.13e-31

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 124.53  E-value: 2.13e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  48 CTIVVALGPITFGFSVGYSSPTQQKLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWI 127
Cdd:cd17436    2 TATVSLLGGLTFGYELGIISGALLQLQTDFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 128 LNALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSY-----LGGLVLPWRTLALV 202
Cdd:cd17436   82 ILTLAGSFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYalnyfFSNVLTGWRYMFGL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 203 GVAPCSVLLVGLFFIPESPrwlakmgiedtlitslqalrgkdsdissEVSEIKDavdisykqeaNVRMSDLCKKTIFLpl 282
Cdd:cd17436  162 AIIPAAIQFASILLLPKKP----------------------------EVLNIKD----------NMRRRTLVGLGLVL-- 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 283 titiglllLQQISGINAILFYSSAIFHSAGFSSSNLASLSLA---LLQVVMTGVAAVLMDRAGRRLLLMVSGAGMAVSCF 359
Cdd:cd17436  202 --------FQQFTGQPNVLCYASTIFRSVGFQSNSSAVLASVglgVVKVIATLLAMLFADRAGRRSLLIAGCSVMAVSVS 273
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 360 LVGFAfylqqhmdatshfapfvgnLALISLLVYITSFALGMGPIPWIIMSEVLPAHIKGLGGSVATLVNWTFSWLVTMSF 439
Cdd:cd17436  274 GIGLW-------------------ITLLCLMAFVSAFSIGFGPMTWLVLSEIYPADIRGRAFSFCNSFNWAANLLITLSF 334
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 302756467 440 NFLLN-WSSTGSFALFAGMCAFTVLFVAVLVPETRGRTLEEI 480
Cdd:cd17436  335 LDLIDvIGLSWTFLLYGVVGVAGVVFIYLFVPETKGQSLEEI 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
50-432 2.57e-19

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 88.88  E-value: 2.57e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  50 IVVALGPITFGFSVGYSSPTQQKLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILN 129
Cdd:COG2814   13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 130 ALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSYLGGLVL----PWRTLALVGVA 205
Cdd:COG2814   93 ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLadlfGWRWVFLVNAV 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 206 PCSV-LLVGLFFIPESPRwlakmgiedtlitslqalrgkdsdissevseikdavdiSYKQEANVRMSDLCKKTIFLPLTI 284
Cdd:COG2814  173 LALLaLLLLLRLLPESRP--------------------------------------AARARLRGSLRELLRRPRLLLLLL 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 285 TIGLLLLQQISGINAILFYSSAIFHsAGFSSSNLASLSLALLQVVMTGVAAVLMDRAGRRLLLMVSGAGMAVSCFLVGFA 364
Cdd:COG2814  215 LAFLLGFGFFALFTYLPLYLQEVLG-LSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALA 293
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 302756467 365 fylqqhmdatshfapfvGNLALISLLVYITSFALGM-GPIPWIIMSEVLPAHIKGLGGSVATLVNWTFS 432
Cdd:COG2814  294 -----------------GSLWLLLLALFLLGFGFGLlFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
89-479 3.31e-19

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 90.08  E-value: 3.31e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467   89 SLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNL 168
Cdd:TIGR00898 134 SCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQ 213
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  169 RGSLGAINQLSVTTG-IFLSYLGGLVLPWRTLALVGVAPCSVLLVGLFFIPESPRWLAKMGIEDTLITSLQALRGKDS-D 246
Cdd:TIGR00898 214 RAIVGTLIQVFFSLGlVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGkK 293
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  247 ISSEVSEIKDAVDISYKQEA-----NVRMSDLCKKTIFLPLtitigllllqqISGINAILFYSSAIFHSAGFSSSNLASL 321
Cdd:TIGR00898 294 LPAEVLSLSLEKDLSSSKKQysfldLFRTPNLRKTTLCLMM-----------LWFTTAFSYYGLVLDLGNLGGNIYLDLF 362
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  322 SLALLQVVMTGVAAVLMDRAGRRLLLMVSGAGMAVSCFLVGFafylqqhmdaTSHFAPFVgnlaLISLLVYITSFALGMG 401
Cdd:TIGR00898 363 ISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLF----------VPVDLYFL----RTALAVLGKFGITSAF 428
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  402 PIPWIIMSEVLPAHIKGLG---GSVATLVNWTFSWLVTMSFNFLLNWSstgsFALFaGMCAFTVLFVAVLVPETRGRTLE 478
Cdd:TIGR00898 429 QMVYLYTAELYPTVVRNLGvgvCSTMARVGSIISPFLVYLGEKWLFLP----LVLF-GGLALLAGILTLFLPETKGVPLP 503

                  .
gi 302756467  479 E 479
Cdd:TIGR00898 504 E 504
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
49-225 1.26e-16

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 80.24  E-value: 1.26e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  49 TIVVALGPITFGFSVGYSSPTQQKLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWIL 128
Cdd:COG0477   16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 129 NALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSYLGGLVL----PWRTLALVGV 204
Cdd:COG0477   96 CGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLvaalGWRWIFLINA 175
                        170       180
                 ....*....|....*....|.
gi 302756467 205 APCSVLLVGLFFIPESPRWLA 225
Cdd:COG0477  176 PLGLLALVLRLRLPESRGLLL 196
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
64-260 1.60e-16

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 81.25  E-value: 1.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467   64 GYSSPTqqkLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARL 143
Cdd:TIGR00895  37 GFAAPA---ISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRF 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  144 LVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFL-SYLGGLVLP---WRTLALVG-VAPCSVLLVGLFFIP 218
Cdd:TIGR00895 114 LAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVgGFLAGWLIPvfgWRSLFYVGgIAPLLLLLLLMRFLP 193
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 302756467  219 ESPRWLAKMGIEDTLITSLQALRGKDSDISSEVSEIKDAVDI 260
Cdd:TIGR00895 194 ESIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGT 235
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
61-231 4.35e-16

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 81.18  E-value: 4.35e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467   61 FSVGYSSPTQQKlteDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYI 140
Cdd:TIGR01299 184 FVVGFVLPSAEK---DLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLF 260
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  141 ARLLVGFGVGVISFTVPMYIAEISPKNLRGS-LGAINQLSVTTGIFLSYLGGLVLP----------------WRTLALVG 203
Cdd:TIGR01299 261 CRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEhLSWLCMFWMIGGIYAAAMAWAIIPhygwsfqmgsayqfhsWRVFVIVC 340
                         170       180
                  ....*....|....*....|....*...
gi 302756467  204 VAPCSVLLVGLFFIPESPRWLAKMGIED 231
Cdd:TIGR01299 341 AFPCVFAIGALTFMPESPRFFLENGKHD 368
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
61-231 6.24e-16

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 79.84  E-value: 6.24e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  61 FSVGYSSPTQQKlteDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYI 140
Cdd:cd17363   16 FVVGFVLPSAEK---DMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLF 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 141 ARLLVGFGVGVISFTVPMYIAEISPKNLRGS-LGAINQLSVTTGIFLSYLGGLVLP----------------WRTLALVG 203
Cdd:cd17363   93 CRLLSGIGIGGSIPIVFSYFAEFLAREKRGEhLSWLCMFWMIGGLYASAMAWAIIPhygwgfsmgtayqfhsWRVFVIVC 172
                        170       180
                 ....*....|....*....|....*...
gi 302756467 204 VAPCSVLLVGLFFIPESPRWLAKMGIED 231
Cdd:cd17363  173 ALPSVASVVALTFMPESPRFLLEVGKHD 200
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
61-231 7.91e-16

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 79.58  E-value: 7.91e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  61 FSVGYSSPTQQKlteDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYI 140
Cdd:cd17438   16 FVVGFVLPSAEK---DMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLF 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 141 ARLLVGFGVGVISFTVPMYIAEISPKNLRGS-LGAINQLSVTTGIFLSYLGGLVLP----------------WRTLALVG 203
Cdd:cd17438   93 CRLISGFGIGGSLPIVFAYFSEFLAREKRGEhLSWLCMFWMIGGLYASAMAWSIIPhygwgfsmgtnyhfhsWRVFVIIC 172
                        170       180
                 ....*....|....*....|....*...
gi 302756467 204 VAPCSVLLVGLFFIPESPRWLAKMGIED 231
Cdd:cd17438  173 ALPCIASIIALKFMPESPRFLLEMGKHD 200
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
52-468 4.61e-14

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 73.61  E-value: 4.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  52 VALGPITFGFSVGYSSPTQQKLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNAL 131
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 132 AMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSYLGGLVL------PWRTLALVGVA 205
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILasslgfGWRAVFLIAAA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 206 PCSVLLVGLFFIPESPRWLAKMGIEDTLITSLQALRGKDsdissevseikdavdisykqeanvrmsdLCKKTIFLPLTIT 285
Cdd:cd06174  161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRV----------------------------LKNPGLWLLLLAI 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 286 IGLLLLQQIsgINAILFYSSAIFHSAGFSSSNLASLSLALLQVVMTGVAAVLMDR-AGRRLLLMVSGAGMAVSCFLVGFA 364
Cdd:cd06174  213 FLVNLAYYS--FSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLA 290
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 365 FYLQqhmdatshfapfvgnlALISLLVYITSFALGMGPIPWIIMSEVLPAHIKGLGGSVATLVNWTFSWLVTMSFNFLLN 444
Cdd:cd06174  291 PSLL----------------LLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLA 354
                        410       420
                 ....*....|....*....|....
gi 302756467 445 WSSTGSFALFAGMCAFTVLFVAVL 468
Cdd:cd06174  355 ATFGLTGAFLVLAVLLLLAAILLL 378
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
61-467 5.90e-14

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 73.02  E-value: 5.90e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  61 FSVGYSSPTQQKLtEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYI 140
Cdd:cd17316   16 FLIGFVAPVLAAE-FSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLV 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 141 ARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSYLGGLVLP--------WRTLALVGVAPCsvlLV 212
Cdd:cd17316   95 LRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIpllsgdwgWRILFLIGALPA---LL 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 213 GLFFIPESPRWLAKMGIEDTLITSLqalrgkdsdissevseikdavdisykqeanvrmsdlckkTIFLPltitiglLLLQ 292
Cdd:cd17316  172 ALLLRRRTLLLILLWFFISFGYYGL---------------------------------------TTFLP-------TYLQ 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 293 QISGINAILFYSSAIFHSAGFsssnlaslslallqVVMTGVAAVLMDRAGRRLLLMVSGAGMAVSCFLVGFAFYLqqhmd 372
Cdd:cd17316  206 TVLGLSPATSSLYLLLISLGA--------------LVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSG----- 266
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 373 atshfapfvGNLALISLLVYITSFALGMGPIPWIIMSEVLPAHIK----GLGGSVATLVNWTFSWLVTMsfnFLLNWSST 448
Cdd:cd17316  267 ---------SPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRatgvGLSYNLGRLGGGGAPPLIAL---LLASTGGT 334
                        410
                 ....*....|....*....
gi 302756467 449 GSFALFAGMCAFTVLFVAV 467
Cdd:cd17316  335 GVPALILALLAIVALIVAL 353
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
73-229 1.15e-13

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 72.33  E-value: 1.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  73 LTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVi 152
Cdd:cd17371   25 LIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGG- 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 153 SFTVPMY-IAEISPKNLRGSLGAINQLSVTTGIFL-SYLGGLVLP-------WRTLALVGVAPCSVLLVGLFFIPESPRW 223
Cdd:cd17371  104 EWAAGAAlMAEYVPARHRGKALGYVQSGWAVGWLLaTLLAALLFPllppeiaWRVLFLLGALPALLVLFIRRFVKEPPQW 183

                 ....*.
gi 302756467 224 LAKMGI 229
Cdd:cd17371  184 QAARAA 189
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
57-475 2.76e-13

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 71.45  E-value: 2.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  57 ITFGFSVGYS-SPTQQKLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNV 135
Cdd:COG2223   14 FFLAFGVWYLwSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSY 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 136 ASLYIARLLVGFGVGvISFTVPM-YIAEISPKNLRGSLGAINQLSVTTGIFLSYLGGLVLP----WRTLALVGVAPCSVL 210
Cdd:COG2223   94 WLLLLLGLLLGIGGG-GSFAVGIaLVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIaafgWRNAFLILGILLLVV 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 211 LVGLFFIPESPRWLAKMGIEDTLITSLQALRGKDsdissevseikdavdisykqeanvrmsdlckkTIFLPLTITIGlll 290
Cdd:COG2223  173 AVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPR--------------------------------FWLLSLLYFGT--- 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 291 lqqISGINAILFYSSAIFHSAgFSSSNLASLSLALLQVVMTGVAAVLM----DRAGRRLLLMVSGAGMAVSCFLVGFAfy 366
Cdd:COG2223  218 ---FGSFIGFSSWLPPYLVDQ-FGLSAATAGLLAALFALLGALGRPLGgwlsDRIGGRRVLLIVFALMALGLLLLALA-- 291
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 367 lqqhmdatshFAPFVgnLALISLLVYITSFALGMGPIPWIImSEVLPAHIKGLGGSVATLVNWTFSWLVTMSFNFLLNW- 445
Cdd:COG2223  292 ----------LGSLW--LFLVLFLLLGLALGGGNGAVFALV-PDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAt 358
                        410       420       430
                 ....*....|....*....|....*....|.
gi 302756467 446 -SSTGSFALFAGMCAFTVLFVAVLVPETRGR 475
Cdd:COG2223  359 gSYTAAFLVFAVLALVALVLTLLLYRRPRRA 389
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
61-231 2.96e-12

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 68.40  E-value: 2.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  61 FSVGYSSPTQQKlteDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYI 140
Cdd:cd17440   16 FVVGFVLPSAET---DMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFLF 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 141 ARLLVGFGVGVISFTVPMYIAEISPKNLRGS-LGAINQLSVTTGIFLSYLGGLVLP----------------WRTLALVG 203
Cdd:cd17440   93 CRLLSGFGIGGAVPTVFSYFAEVLAREKRGEhLSWLCMFWMIGGIYASAMAWAIIPhygwsfsmgsayqfhsWRVFVIVC 172
                        170       180
                 ....*....|....*....|....*...
gi 302756467 204 VAPCSVLLVGLFFIPESPRWLAKMGIED 231
Cdd:cd17440  173 ALPCVSSVVALTFMPESPRFLLEVGKHD 200
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
73-215 3.03e-12

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 67.61  E-value: 3.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  73 LTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVI 152
Cdd:cd17365   25 LAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAA 104
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 302756467 153 SFTVPMYIAEISPKNLRGSLGAINQLSVTTG-IFLSYLGGLVLP---WRTLALVGVAPCSVLLVGLF 215
Cdd:cd17365  105 MPNAITLVSEYAPARRRSLAVTLMFCGYPLGaALGGFLAAALIPafgWRSVFLLGGVPPLILLPLLR 171
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
73-212 4.15e-12

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 67.59  E-value: 4.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  73 LTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVI 152
Cdd:COG2271   36 LQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGF 115
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 302756467 153 SFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSYLGGLVL----PWRTLALVGVAPCSVLLV 212
Cdd:COG2271  116 FPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLlaafGWRAAFLILGLPGLLLAL 179
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
79-218 2.51e-10

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 62.17  E-value: 2.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  79 LSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVISFTVPM 158
Cdd:cd17372   31 LSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGGGPQLASW 110
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 302756467 159 YiAEISPKNLRGSLGAINQLSVTTG-IFLSYLGGLVLP---WRTLALVGVAPCSVLLVGLFFIP 218
Cdd:cd17372  111 Y-LEFLPAKSRGTWMVLFSVFWTVGtIFEASLAWLVMPrlgWRWLLAFSSVPSSLLLVFYRWTP 173
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
73-222 2.57e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 61.81  E-value: 2.57e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  73 LTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKG--ALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVG 150
Cdd:COG2271  207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLG 286
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 302756467 151 VISFTVPMYIAEISPKNLRGS-LGAINQLSVTTGIFLSYLGGLVL----PWRTLALVGVAPCSVLLVGLFFIPESPR 222
Cdd:COG2271  287 GAFGLLWALAAELFPKKARGTaSGLVNTFGFLGGALGPLLVGYLLdatgYQAAFLLLAALALLAALLALLLLRETRK 363
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
62-243 5.63e-10

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 61.13  E-value: 5.63e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  62 SVGYSSPtqqKLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIA 141
Cdd:PRK11551  33 SAGVAAP---RMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVA 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 142 RLLVGFGVGVisfTVPMYIA---EISPKNLRGSLGAINQLSVTTGIFLSYLGGLVLP----WRTLALV-GVAPCSVLLVG 213
Cdd:PRK11551 110 RLLTGVGLGG---ALPNLIAltsEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAgdaaWRHIFYVgGVGPLLLVPLL 186
                        170       180       190
                 ....*....|....*....|....*....|
gi 302756467 214 LFFIPESPRWLAKMGIEDTLITSLQALRGK 243
Cdd:PRK11551 187 MRWLPESRAFAQAAGAGKQRAPVLRALFGE 216
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
30-187 6.12e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 60.76  E-value: 6.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  30 RGKRREKRVRGSVLYTVFCTIVVALGPITFGFsVGYSSPTQQKLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRF 109
Cdd:COG2814  192 ARARLRGSLRELLRRPRLLLLLLLAFLLGFGF-FALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF 270
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 302756467 110 GRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLS 187
Cdd:COG2814  271 GRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
61-231 1.02e-09

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 60.43  E-value: 1.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  61 FSVGYSSPTQQKlteDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYI 140
Cdd:cd17439   16 FVVGFVLPSAEK---DMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLF 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 141 ARLLVGFGVGVISFTVPMYIAEISPKNLRGS-LGAINQLSVTTGIFLSYLGGLVLP----------------WRTLALVG 203
Cdd:cd17439   93 CRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEhLSWLCMFWMIGGIYASAMAWAIIPhygwsfqmgsayqfhsWRVFVLVC 172
                        170       180
                 ....*....|....*....|....*...
gi 302756467 204 VAPCSVLLVGLFFIPESPRWLAKMGIED 231
Cdd:cd17439  173 AFPSVFAIGALTTMPESPRFFLENGKHD 200
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
67-463 2.96e-09

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 58.89  E-value: 2.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467   67 SPTQQKLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIAsiphIAGW----ILNALAMNVASLYIAR 142
Cdd:TIGR00893  14 SFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVF----IVIWgvftGLQAFAGAYVSLYILR 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  143 LLVGFGVGVISFTVPMYIAEISPKNLRGSLGAI-NQLSVTTGIFLSYLGGLVL---PWRTLALVGVAPCSVLLVGLFFI- 217
Cdd:TIGR00893  90 VLLGAAEAPFFPGIILIVASWFPASERATAVSIfNSAQGLGGIIGGPLVGWILihfSWQWAFIIEGVLGIIWGVLWLKFi 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  218 ---PESPRWLAKmgiEDTLITSLQALRGKDSDISSEVS--EIKDAVdisykqeANVRMSdlckkTIFLPLtitigllllq 292
Cdd:TIGR00893 170 pdpPQKAKWLTE---EEKYIVVGGLLAEQQGKGPSTPKkyQIKELL-------KDRRVW-----GLALGQ---------- 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  293 qiSGINAIL-----FYSSAIFHSAGFSSSNLASLSLALLQVVMTGVA--AVLMDRAGRRLLLMVSGAGMAVSCFLVgfaf 365
Cdd:TIGR00893 225 --FLVNIGLgffltWFPTYLVQERGLSILEAGFMASLPGIVGFIGMIlgGRLSDLLLRRGKSLVFARKTAIIAGLV---- 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  366 ylqqhmdatSHFAPFVGNLALISL----LVYITSFALGMGPIPWIIMSEVLPAHIKGLGGSVATLVNW--------TFSW 433
Cdd:TIGR00893 299 ---------LSLLMFATNYVNIPYaalaLVALGFFGLGAGAIGWALISDNAPGNIAGLTGGLINSLGNlggivgpiVIGA 369
                         410       420       430
                  ....*....|....*....|....*....|
gi 302756467  434 LVTMSFNFLLNWSSTGSFALFAGMCAFTVL 463
Cdd:TIGR00893 370 IAATTGSFAGALMVVAALALIGALSYLLLV 399
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
49-218 2.98e-09

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 58.71  E-value: 2.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  49 TIVVALGPITFGFSVGYSSPTQQKLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWIL 128
Cdd:COG0738   10 LIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 129 NALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLR---GSLGAINQLSVTTGIFLSYL---GGLVLPWRTLALV 202
Cdd:COG0738   90 FALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAAsrlNLLHAFFSLGALLGPLLGGLlilLGLSLSWHLPYLI 169
                        170
                 ....*....|....*.
gi 302756467 203 GVAPCSVLLVGLFFIP 218
Cdd:COG0738  170 LAVLLLLLALLFLRSK 185
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
45-217 4.15e-09

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 58.00  E-value: 4.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  45 TVFCTIVVALGPITFgfsVGYSSPTQQKLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIA 124
Cdd:cd17316  179 TLLLILLWFFISFGY---YGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 125 GWIL--NALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGS-LGAINQLSVTTGIFLSYLGGLVLPWR-TLA 200
Cdd:cd17316  256 LALPlfYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATgVGLSYNLGRLGGGGAPPLIALLLASTgGTG 335
                        170
                 ....*....|....*..
gi 302756467 201 LVGVAPCSVLLVGLFFI 217
Cdd:cd17316  336 VPALILALLAIVALIVA 352
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
85-218 9.71e-09

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 56.82  E-value: 9.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  85 SMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVISFTVPMYIAEIS 164
Cdd:cd17317   28 ALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIV 107
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 302756467 165 PKNLRGSLGAINQLSVTTG-IFLSYLGGLVLPWRTLALVGVAPCSVLLVGLFFIP 218
Cdd:cd17317  108 GPKYRSFVGILFGLFWALGyMLLALLAYLIRDWRWLQLAISLPGLLFLLLLWWLP 162
MFS_1 pfam07690
Major Facilitator Superfamily;
73-428 1.28e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 56.66  E-value: 1.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467   73 LTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVI 152
Cdd:pfam07690  23 LAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGAL 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  153 SFTVPMYIAEISPKNLRGS----LGAINQLSVTTGIFLSYLGGLVLPWRTLALVGVAPCSVLLVGLFFIPESPRwlakmg 228
Cdd:pfam07690 103 FPAALALIADWFPPEERGRalglVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPE------ 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  229 iedtlitslqalrgkdsdissevseikdaVDISYKQEANVRMSDLCKKTIFLPLTITIGLLLLQQISGINAILFYSSAIF 308
Cdd:pfam07690 177 -----------------------------SKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  309 HSAGF--SSSNLASLSLALLQVVMTGVAAVLMDRAGRRLLLMVSGAGMAVSCFLVGFafylqqhmdatshFAPFVGNLAL 386
Cdd:pfam07690 228 EVLGLsaLLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLL-------------LSLTLSSLWL 294
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 302756467  387 ISLLVYITSFALGMGPIPWIIMSEVLPAHIKGLGGSVATLVN 428
Cdd:pfam07690 295 LLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAG 336
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
77-194 1.96e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 56.45  E-value: 1.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  77 LGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALA--MNVASLYIARLLVGFGVGVISF 154
Cdd:COG2211  259 LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILV 338
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 302756467 155 TVPMYIAEISP-------KNLRGSLGAINQLSVTTGIFLS-YLGGLVL 194
Cdd:COG2211  339 LPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAgALAGLLL 386
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
86-218 2.06e-08

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 55.82  E-value: 2.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  86 MYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISP 165
Cdd:cd17379   37 LFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVG 116
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 302756467 166 KNLRGSLGAINQLSVTTGIFLSYLGGLVLP-WRTLALVGVAPCSVLLVGLFFIP 218
Cdd:cd17379  117 SKYRRTVGIVYQMFFTLGLLILPGIAYFIPhWRWLQLAVTLPNFLFLLYYWFIP 170
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
75-247 2.06e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 56.05  E-value: 2.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  75 EDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVISF 154
Cdd:cd17325   24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 155 TVPMYIAEISPKNLRGSLGAINQLSVTTGIFLS-YLGGLVLPWR----TLALVGVAPCSVLLVGLFFIPESPRWLAKMGI 229
Cdd:cd17325  104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGpLLGGLLADALgyraPFLVCAALALLALVLALLLLPEPRPPPNKRAV 183
                        170
                 ....*....|....*...
gi 302756467 230 EDTLITSLQALRGKDSDI 247
Cdd:cd17325  184 SAARLRSGLRLLLRDRRL 201
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
73-222 2.44e-08

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 55.63  E-value: 2.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  73 LTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVI 152
Cdd:cd17324   25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGF 104
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 302756467 153 SFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSY-LGGLV---LPWR-TLALVGVAPCSVLLVGLFFIPESPR 222
Cdd:cd17324  105 WAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRpLGGLLgqlLGWRaAFLAIAVLALLAALLLWRLLPSLPP 179
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
75-222 6.07e-08

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 54.88  E-value: 6.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  75 EDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVISF 154
Cdd:COG2807   46 ADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNV 125
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 302756467 155 TVPMYIAEISPKNlRGSLGAINQLSVTTGIFLSylGGLVLP------WR-TLALVGVAPCSVLLVGLFFIPESPR 222
Cdd:COG2807  126 LLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALA--AGLTVPlaaalgWRgALAVWALLALLALLLWLPLLRRRPA 197
2_A_01_02 TIGR00880
Multidrug resistance protein;
85-220 6.58e-08

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 51.50  E-value: 6.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467   85 SMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVISFTVPMYIAEIS 164
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 302756467  165 PKNLRG-SLGAINQLSVTTGIFLSYLGGLV---LPWR-TLALVGVAPCSVLLVGLFFIPES 220
Cdd:TIGR00880  81 PPEERGvALGLMSAGIALGPLLGPPLGGVLaqfLGWRaPFLFLAILALAAFILLAFLLPET 141
PRK03893 PRK03893
putative sialic acid transporter; Provisional
89-240 6.63e-08

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 54.70  E-value: 6.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  89 SLVNAGAMA---GAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISP 165
Cdd:PRK03893  59 SLISAAFISrwfGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWP 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 166 KNLRG--SLGAINQLSVTTGIfLSYLGGLVLP---WRTLALVGVAPCSVLLVGLFFIPESPRWLAKMGIEDTLITSLQAL 240
Cdd:PRK03893 139 KHLRNkaSGFLISGFSIGAVV-AAQVYSLVVPvwgWRALFFIGILPIIFALWLRKNLPEAEDWKEKHAGKAPVRTMVDIL 217
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
89-224 9.66e-08

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 54.05  E-value: 9.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  89 SLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVISFTVPMYiAEISPKNL 168
Cdd:cd17441   41 SVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGGVPQSVTLY-AEFLPMKS 119
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 169 RGSLGAINQLSVTTG-IFLSYLGGLVLP---WRTLALVGVAPCSVLLVGLFFIPESPRWL 224
Cdd:cd17441  120 RAKCILLIEVFWALGtVFEVLLAVFVMPtlgWRWLLILSALPLLIFAVLCFWLPESARYW 179
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
76-221 2.44e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 52.60  E-value: 2.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  76 DLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVISFT 155
Cdd:cd17489   25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 156 VPMYIAEISPKNLRGSLGAINQLSVTTGIFL-SYLGGLVLPW---RTLALVGVAPCSVLLVGLFFIPESP 221
Cdd:cd17489  105 AATLVADIIPPSRRGEGIGYYGLATTLAMALgPALGLFLYQHlgfAVLFIVAAVLALLALLLVFLVKDPP 174
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
93-218 4.12e-07

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 52.04  E-value: 4.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  93 AGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGF---GVGVISFTVPMYIAEISPKNLR 169
Cdd:cd17447   46 AGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFaltGFSIISMVLCVEWVDIEHRTVA 125
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 302756467 170 GSLGAinqLSVTTG-IFLSYLGGLVLPWRTLALVGVAPCSVLLVGLFFIP 218
Cdd:cd17447  126 GVLIS---LFWTVGnMLLALVAYLIRDWRWLILAVTLPCAPGIITWWWVP 172
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
83-218 4.51e-07

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 51.70  E-value: 4.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  83 EFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVISFTVPMYIAE 162
Cdd:cd17377   40 KVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMSLVAFVLLNE 119
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 302756467 163 ISPKNLRGSLGAINQLSVTTGI-FLSYLGGLVLPWRTLALVGVAPCSVLLVGLFFIP 218
Cdd:cd17377  120 CVGKSYWALAGSLGGLFFAVGIaQYALLGYFIRSWRTLAVVVNLQGTLVFLLSLFIP 176
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
94-222 5.56e-07

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 51.85  E-value: 5.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  94 GAMAGAILSGRIADRFGRKGALVIAsiphIAGW----ILNALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLR 169
Cdd:cd17328   46 SYMVLSPIFGYLGDRYNRKWILAVG----ILIWsaatLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKR 121
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 170 GSLGAINQLSVTTGIFLSYLGG-----LVLPWRtLALVGVAPCSVLLVGL--FFIPESPR 222
Cdd:cd17328  122 TRALGVFYFAIPLGSGLGYVVGglvaqATGGWR-WAFRVTGVLGVLLAILllLFVREPPR 180
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
72-222 1.28e-06

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 50.27  E-value: 1.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  72 KLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGV 151
Cdd:cd17330   24 REFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGN 103
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 302756467 152 ISfTVPMYIAEISPKNLR----GSLGAINQLSVTTG----IFLSYLGGLVLPwrtLALVGVAPCSVLLVGLFFIPESPR 222
Cdd:cd17330  104 VS-VAQAYIADITDEEERakafGIISAAFGLGFILGpalgGFLSTPYGYALP---FLVAAALALLNLVLVLFFLPPLRR 178
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
50-187 1.66e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 50.26  E-value: 1.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  50 IVVALGPITFGFSVGYSSPTQ--QKLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWI 127
Cdd:cd17473  199 VLPIYFLAFLAMLLFYVIPIQlpFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFL 278
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 128 LNALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLS 187
Cdd:cd17473  279 LLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLS 338
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
85-227 2.79e-06

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 49.21  E-value: 2.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  85 SMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVISFTVPMYIAEIS 164
Cdd:cd17374   38 SVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWT 117
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 302756467 165 PKNLRGSLGAINQLSVTTGIFLsyLGGL---VLPWRTLALVGVAPCsvllvGLFFIpeSPRWLAKM 227
Cdd:cd17374  118 TPRHRALAITLTSCFFSIGQML--LAGLayaIRDWRLLQLVVSVPF-----FLFFL--YSWWLPKR 174
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
73-217 3.55e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 49.11  E-value: 3.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  73 LTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVI 152
Cdd:cd17325  226 AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLV 305
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 302756467 153 SFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFL-SYLGGLVLPWRTLALVGVAPCSVLLVGLFFI 217
Cdd:cd17325  306 FPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLgPLLGGFLYDAFGFATPFLAAAALLLLAAVLF 371
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
98-194 4.46e-06

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 48.83  E-value: 4.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  98 GAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVAS--------LYIARLLVGFGVGVISFTVPMYIAEISPKNLR 169
Cdd:cd17367   56 GGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATigiwapiiLLLARLLQGLSVGGEYGTSATYLSEVAPPGRR 135
                         90       100
                 ....*....|....*....|....*
gi 302756467 170 GSLGAINQLSVTTGIFLSYLGGLVL 194
Cdd:cd17367  136 GFYSSFQYVTLIGGQLLALGVLLVL 160
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
52-218 4.62e-06

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 48.71  E-value: 4.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  52 VALGPITFGFSVGYSSPTQQKLTEDLGLSLSE----FSMYgSLVNAGAMagaILSGRIADRFGRKGALVIASIPHIAGWI 127
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQlqwvVNAY-LLAFAALL---LLAGRLGDRFGRKRVFLIGLALFGLASL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 128 LNALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFL-SYLGGLVLP---WRTLALVG 203
Cdd:cd17321   77 LCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALgPLLGGLLLElfgWRWIFLIN 156
                        170
                 ....*....|....*
gi 302756467 204 VApcsVLLVGLFFIP 218
Cdd:cd17321  157 VP---IGLVALLLAR 168
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
86-218 4.65e-06

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 48.57  E-value: 4.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  86 MYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISP 165
Cdd:cd17446   37 LAQSIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMP 116
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 302756467 166 KNLRGSLGAINQLSVTTGIF-LSYLGGLVLPWRTLALVGVAPCSVLLVGLFFIP 218
Cdd:cd17446  117 TRVRAVVGTLLGYCYTLGQLiLAGVAYAIRDWRWLQLAVSLPFFIFFLYSWWFP 170
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
73-217 7.96e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 47.93  E-value: 7.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  73 LTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVI 152
Cdd:cd17324  225 LTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAA 304
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 302756467 153 SFTVPMYIAEISPKNlRGSLGAINQLSVTTGIFL-SYLGGLVLPWRTLALVGVAPCSVLLVGLFFI 217
Cdd:cd17324  305 HSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALgAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
MFS_SLC37A4 cd17343
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ...
51-216 9.59e-06

Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340901 [Multi-domain]  Cd Length: 409  Bit Score: 47.71  E-value: 9.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  51 VVALG-PITFGFSVGYSSPTQQKLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIaGWILN 129
Cdd:cd17343  220 LLSLGyLVVFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSSSRGNPRM-PLALV 298
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 130 ALAMNVASLYIAR------------LLVGFGVGVISF-TVPMY--IA-EISPKNLRGSLGAINQLSVTTGIFL-----SY 188
Cdd:cd17343  299 FMAGLTVSLHLFRvhitsdsselfiLLLGFLIGFSLYgPIAIFgvIAnESAPSHLCGTSHAIVALAANVGGVLaglpfSY 378
                        170       180
                 ....*....|....*....|....*...
gi 302756467 189 LGGLvLPWRTLALVGVAPCSVLLVGLFF 216
Cdd:cd17343  379 IAKH-YDWRTAFLLLEILCAITVVILFL 405
PRK12307 PRK12307
MFS transporter;
76-223 9.99e-06

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 48.00  E-value: 9.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  76 DLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVISFT 155
Cdd:PRK12307  47 DLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYAC 126
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 302756467 156 VPMYIAEISPKNLRGSLGA--INQLSVTTGIFLSYLGGL--VLPWRTLALVGVAPCSVLLVGLFFIPESPRW 223
Cdd:PRK12307 127 ASTYAVESWPKHLKSKASAflVSGFGIGNIIAAYFMPSFaeAYGWRAAFFVGLLPVLLVIYIRARAPESKEW 198
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
52-152 1.50e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 47.19  E-value: 1.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  52 VALGPITFGFSVGYSSPTQQKLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNAL 131
Cdd:cd17504    1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
                         90       100
                 ....*....|....*....|.
gi 302756467 132 AMNVASLYIARLLVGFGVGVI 152
Cdd:cd17504   81 APNLPVLIAGRALQGIGGAVF 101
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
74-217 2.52e-05

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 46.68  E-value: 2.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  74 TEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIAsiphIAGWILNALAMNVAS----LYIARLLVGFGV 149
Cdd:COG2270  266 AGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVS----LVIWIVVCLAAYFLTtalaFWILGLLIGLVM 341
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 302756467 150 GVI---SFTvpmYIAEISPKNLRGSLGAINQLSVTTGIFlsyLGGLVLPWrTLALVGVAPCSVLLVGLFFI 217
Cdd:COG2270  342 GGIqalSRS---LLARLIPPGREAEFFGLYALSGKAASF---LGPLLFGL-VTQLTGSQRLGILSLIVFFV 405
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
98-424 2.85e-05

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 46.21  E-value: 2.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  98 GAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVAS--------LYIARLLVGFGVGVISFTVPMYIAEISPKNLR 169
Cdd:cd17368   56 GAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYATigiaapllVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRR 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 170 GSLG----AINQLSVTTGIFLSYLGGLVLP--------WRTLALVGVAPCSVLLVGLFFIPESPRWLAKMgiedtlitsl 237
Cdd:cd17368  136 GFYTswqsASQQVAIVAGALVGYLLSLTLTaealaewgWRIPFFIGLLIIPLGLWLRRSLEETEAFLERK---------- 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 238 qalrgKDSDISSEVSEIKDAvdisykqeanvrmsdlcKKTIFLPLTITIGLLLLQQISGINAILFYSSAIFHSAGFSSSN 317
Cdd:cd17368  206 -----ARPTRRELFALLANN-----------------RRIILLGMLLVAGSTVTFYFTTVYTPTYAKTVLGLSARDSFLV 263
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 318 LASLSLALLQVVMtgVAAVLMDRAGRRLLLMVSGAGMAVScflvgfAFYLQQHMDATSHFAPFVGNLALISLLvyitsFA 397
Cdd:cd17368  264 TLLAGVANFIWAP--LGGALSDRIGRRPVLLVITLAALVT------LYPVFAWLTAAPSFGRLLLVLLVLSFF-----FG 330
                        330       340
                 ....*....|....*....|....*..
gi 302756467 398 LGMGPIPwIIMSEVLPAHIKGLGGSVA 424
Cdd:cd17368  331 MYGGAMV-VALVELFPVRVRSTGFSLV 356
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
57-221 3.38e-05

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 46.16  E-value: 3.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  57 ITFGFSVGYSSPTQQKLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVA 136
Cdd:cd17333    6 FSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 137 SLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSYLGGLVLPWR---TLALVGVAPCSVLLVG 213
Cdd:cd17333   86 LFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSElswSWAYLIIGLIYLLLAI 165

                 ....*...
gi 302756467 214 LFFIPESP 221
Cdd:cd17333  166 LILLTLFP 173
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
75-243 3.83e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 45.64  E-value: 3.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  75 EDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVISF 154
Cdd:cd17474   27 EALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGP 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 155 TVPMYIAEISPKNLRGSLGAINQLSVTTGIFLS-YLGGLV--LPWRTLALVGVAPCSVLLVGLFFIPESPRWLAKMGIED 231
Cdd:cd17474  107 LALTLIGDLFEGGERAKAMGLYEAALGLGIAVGpLLGGLLaaISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSAT 186
                        170
                 ....*....|..
gi 302756467 232 TLITSLQALRGK 243
Cdd:cd17474  187 KLRDLKKALRGR 198
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
72-212 4.28e-05

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 45.65  E-value: 4.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  72 KLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVAS-LYIARLLVGFGVG 150
Cdd:cd17365  196 KLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVlLYVLVFLAGACVN 275
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 302756467 151 VISFTVPMYIAEISPKNLRGS-LGAINQLSVTTGIFLSYLGGLVL------PWRTLALVGVAPCSVLLV 212
Cdd:cd17365  276 GAQVGLYALAARFYPTEVRATgVGWALGVGRLGAILGPLLGGLLLaaglgpESVFLALAIPAALGALAV 344
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
73-219 4.58e-05

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 45.76  E-value: 4.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  73 LTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNA-LAMNVASLYIARLLVGFGVGV 151
Cdd:cd17371  236 LTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFfLPLSPTLILILGFPLGFFASG 315
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 302756467 152 ISFTVPMYIAEISPKNLRGS-LGAINQLSVTTGIFLSYLGGLVLPWRTL----ALVGVAPCSVLLVGLFFIPE 219
Cdd:cd17371  316 PFSGMGAYLTELFPTAVRATaQGFCYNVGRIIGALFPFLVGFLATSGSLgtaiAVFAAVYYIAGLVLALLLPE 388
MFS_1 pfam07690
Major Facilitator Superfamily;
46-187 5.01e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 45.49  E-value: 5.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467   46 VFCTIVVALGPITFGFSVGYSSPTqqkLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHI-- 123
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPL---YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLIla 278
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 302756467  124 -AGWILNALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLS 187
Cdd:pfam07690 279 aLGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
73-220 5.49e-05

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 45.45  E-value: 5.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467   73 LTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVI 152
Cdd:TIGR00710  31 IAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAG 110
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 302756467  153 SFTVPMYIAEISPKN-LRGSLGAINQLSVTTGIFLSYLGGLVLPW-------RTLALVGVApcsVLLVGLFFIPES 220
Cdd:TIGR00710 111 SVISQALVRDIYPGEeLSRIYSILMPVLALAPAVAPLLGGYILVWlswhaifAFLSLAGIL---LSALIFFILPET 183
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
90-216 9.55e-05

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 44.92  E-value: 9.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  90 LVNAGAMAGAILS---GRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGvISFTVPMYIAEISPK 166
Cdd:cd06179   37 ISTAWSLAQAVLGpivGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAG-TQGLGAAVASELVPN 115
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 302756467 167 NLRGS-LGAINQLSVTTGIFLSYLGGLVLP-----WRTLALVGVAPCSVLLVGLFF 216
Cdd:cd06179  116 KYRGLvQGVVNLVASPGSALGPLIAGALVEanaagWRWIFYINAIFNALALILLFF 171
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
75-217 1.02e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 44.53  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  75 EDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVISF 154
Cdd:cd06173  237 EVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNV 316
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 302756467 155 TVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSY-LGGLVLPWRTLALVGVAPCSVLLVGLFFI 217
Cdd:cd06173  317 PLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGAlLAGLLADALGLSAVFLLAGALLLLAALLL 380
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
92-472 1.31e-04

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 44.19  E-value: 1.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  92 NAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMN------VASLYIARLLVGFGVGVISFTVPMYIAEISP 165
Cdd:cd17364   49 LVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGstplgvMGWLIFFRFLLGIGIGGDYPLSATIMSEYAN 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 166 KNLRGSL----------GAINQLSVT---TGIFLSYLGGLVLP-----WRTLALVG-VAPCSVLLVGLFFIPESPRWLAk 226
Cdd:cd17364  129 KKRRGALiaavfamqgfGILAGAIVTlilSAIFEHPLPAGTYHhadlvWRIVLGLGaIPALSVLYFRKHLLGTAGTWFL- 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 227 mgiedtlitslqalrgkdsdissevseikdaVDISYKQeanvrmSDLCKKTIFlpltitigllllqqisgiNAILFYSSA 306
Cdd:cd17364  208 -------------------------------LDIAFYG------QNLFQSTII------------------SAIGFSKTM 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 307 IFHSAGFSSSNLASLSLALLQVVMTGVAAVLMDRAGRRLLLMVSGAGMAVscFLVGFAFYLQQhmdatshfapFVGNLAL 386
Cdd:cd17364  233 NAYQELFNIAVGQLIIALAGTVPGYWFTVFLIDRIGRKKIQMMGFFGMTI--FLLILAGPYDH----------WKISTIG 300
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 387 ISLLVYITSFALGMGP--IPWIIMSEVLPAHIKGLGGSVATLVNWTFSWLVTMSFNFLLNWSSTGSFALFAGMCAFTVLF 464
Cdd:cd17364  301 FFVLYGLTFFFSNFGPntTTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFLSLTQNIGVRNVLIILAGVALLGII 380

                 ....*...
gi 302756467 465 VAVLVPET 472
Cdd:cd17364  381 LTLLFPEE 388
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
73-222 1.44e-04

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 44.13  E-value: 1.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  73 LTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVI 152
Cdd:cd17331   26 LTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLPSVFMHAMQ 105
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 302756467 153 SFTvpMYIAEISPKNLR-GSLGAINqLSVTTGIFL-SYLGGLV---LPWRTLALVGVAPCSVLLVGLF-FIPESPR 222
Cdd:cd17331  106 AAQ--MVVTDLTDPGERaAALGRLG-LSYGIGMVVgSFLGGLLtkkFGEQAAALVAAVGSLLSIVLVIlLIPSNTK 178
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
101-218 2.01e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 43.72  E-value: 2.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 101 LSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSV 180
Cdd:cd17503   50 LSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVI 129
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 302756467 181 TTGIFLS-YLGGLV---LPWRTLALVGVAPCSVLLVGLFFIP 218
Cdd:cd17503  130 LLAPAIGpTLGGWLtdnLSWRWIFYINLPIGILALLLAPLLD 171
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
73-241 2.28e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 43.37  E-value: 2.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  73 LTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVI 152
Cdd:cd17329   26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 153 SFTVPMYIAEISP----KNLRGSLGAINQLSVTTGIFL-SYLGGLVLPWRTLALVGVAPCSVLLVgLFFIPESPRWLAKM 227
Cdd:cd17329  106 EPASEAMIADVTTpenrTRAFSLLYWAINLGVAIGPLLgGLLLLYSFRLLFLAAAVLFLLAALVL-LFLLPETRPKRRAA 184
                        170
                 ....*....|....
gi 302756467 228 GIEDTLITSLQALR 241
Cdd:cd17329  185 EKTEILRGYKIVLR 198
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
75-196 2.63e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 42.94  E-value: 2.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  75 EDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIAsiphIAGW----ILNALAMNVASLYIARLLVGFGVG 150
Cdd:cd17319   31 KDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVS----MLLWslftALTGFATSLTSLYVLRFLLGVAEA 106
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 302756467 151 VISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFlsyLGGLVLPW 196
Cdd:cd17319  107 GFFPGAIKALAEWFPARERGRATGLFNSGAPLGAA---IGPPLSGW 149
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
73-205 2.76e-04

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 43.00  E-value: 2.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  73 LTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFG---RKGALVIASIphIAGWILNALAMNVAS---LYIARLLVG 146
Cdd:cd17475  225 LHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFggrRRPVLVITAA--IAAAALLVLSLLSPGtplWLLVLLLIL 302
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 147 FGVGVISFTVPMY--IAEISPKNLRGSL----GAINQLSVTT-----GIFLSYLGGLVLPWRTLALVGVA 205
Cdd:cd17475  303 LGLFAIGWNGLYLtlVAESAGPEQAGTAlglaNTINFIGIAIgpplfGLLVDATHSYAPAWLALALLLVL 372
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
6-224 3.64e-04

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 43.12  E-value: 3.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467    6 EVGRNGERQP---LLAGKSSKSTGSSSRGKRREKRVRGSvlYTVFCTIVVAlgpiTFgFSVGYSSPTQQKLTEDLGLSLS 82
Cdd:pfam06609   7 EEGLDLESQPddrLRAKALATSAAELPDGYYRSPRIIAS--FAAFSLNVCA----TY-FVLQASASALPNILQDIGQSEN 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467   83 EfSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVISfTVPMYIAE 162
Cdd:pfam06609  80 Q-GLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGVAAGPAG-ASPLFIGE 157
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 302756467  163 I-SPKNLRGSLGAINQLSVTTGIFLSYLG---GLVLPWRTLALVGV--APCSVLLVGLFFIPESPRWL 224
Cdd:pfam06609 158 LmSNKTKFLGLLIVSAPTIAMNGAGPYFGqrlAIQGNWRWIFYIYIimSAIAVLLIIIWYHPPSFAQL 225
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
89-222 3.68e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 42.56  E-value: 3.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  89 SLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNL 168
Cdd:cd17473   42 TLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEE 121
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 302756467 169 RGS-LGAINQLSVTTGIFLSYLGGLV--LPWRTLALVGVAPCSVLLVGLFFIPESPR 222
Cdd:cd17473  122 RAKmLGLQSAAMSLGGVVFLLLGGALaeIGWRAPFLVYLLALPVLILVLLFLPEPAR 178
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
50-221 4.13e-04

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 42.64  E-value: 4.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  50 IVVALGPITFGFSVG---YSSPTQQKLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGW 126
Cdd:cd17355    3 VVLAVTFLILILSWGiryYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 127 ILNALAMNVASLYIAR-LLVGFGVGVISFTVPMYIAEISPKNLRG-SLGAINQLSVTTGIFLSYLGGLVL---PWRT--L 199
Cdd:cd17355   83 VLLALATSLWQLYLLWgLLGGGGAGTLAAVAFATVAAWWFERRRGlALGILTAGGGLGSLVFLPLGAALIeafGWRTalL 162
                        170       180
                 ....*....|....*....|..
gi 302756467 200 ALVGVAPCSVLLVGLFFIPESP 221
Cdd:cd17355  163 VLALLALLVLVPVLLLLRRRPA 184
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
75-219 4.29e-04

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 42.64  E-value: 4.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  75 EDLGL-SLSEFSMY-GSLVNAGAMAGAILS---GRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGV 149
Cdd:cd17391   24 EQLGVtSGGLVELWsGLAFSSTFLVSAIFSpiwGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFS 103
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 302756467 150 GVISFTVPMyIAEISPKNLRG-SLGAINQLSVTTGIFLSYLGGLVLPW----RTLALVGVAPCSVLLVGLFFIPE 219
Cdd:cd17391  104 GYVPNATAL-IASQTPKEKSGwALGTLSTGVVAGTLIGPLLGGFLADLfgirNVFFITGGLLFLAFLLTLFFVKE 177
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
73-217 4.57e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 42.56  E-value: 4.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  73 LTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIP---HIAGWILNALAMNVASLYIARLLVGFGV 149
Cdd:cd17319  206 LKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGlllAAVGLLLAYLTTSPVVAVILLSLAGFGI 285
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 302756467 150 GVISFTVPMYIAEISPKNLRGS-LGAINQLSVTTGIFLSYLGGLVLPWR---TLALVGVAPCSVLLVGLFFI 217
Cdd:cd17319  286 GAASPVFWSLPADLLPGEAAATaGGLINSGGNLGGFVAPLLIGYLVDATgsyTAAFLFLAAVALLAALLVLL 357
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
73-196 4.69e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.53  E-value: 4.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  73 LTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVI 152
Cdd:COG0738  237 LKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLM 316
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 302756467 153 SFTVPMYIAEISPKNLRGSLGAInqlsvttgIFLSYLGGLVLPW 196
Cdd:COG0738  317 FPTIFSLALDGLGKRTAAAVSAV--------LIMGIVGGAIGPP 352
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
94-211 4.88e-04

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 42.12  E-value: 4.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  94 GAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVISFTVpmYIAEIS----PKNLR 169
Cdd:cd17373   37 GLIFGYLILGCIADRFGRRPVLLFSLILILIFGLTVALAVSVTMFSTLRFLEGFCLAGIILTL--YLLRLElcdpGKRLM 114
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 302756467 170 GSLGAiNQLSVTTGIFLSYLGGLVLPWRTLALVGVAPCSVLL 211
Cdd:cd17373  115 ITMVA-SLVAVAGQFLMPGLAALCRDWRVLQALIICPFLLML 155
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
73-242 6.45e-04

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 41.84  E-value: 6.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  73 LTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVI 152
Cdd:cd17475   22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSV 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 153 SFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFlsyLGGLVLP-------WRT-LALVGVAPCSVLLVGLFFIPESPRWL 224
Cdd:cd17475  102 QPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGA---LAAALLPplalhygWRAaFVVAGLVSILAAVLFWLFYREPPAAS 178
                        170
                 ....*....|....*...
gi 302756467 225 AKMGIEDTLITSLQALRG 242
Cdd:cd17475  179 AATESASTLLRSLKEVLR 196
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
98-464 7.17e-04

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 41.74  E-value: 7.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  98 GAILSGRIADRFGRKGALVI------------------ASIPHIAgWILnalamnvasLYIARLLVGFGVGVISFTVPMY 159
Cdd:cd17369   60 GGVVFGHFGDRIGRKKTLVLtlllmgiatfligllptyAQIGILA-PIL---------LVLLRLLQGLALGGEWGGAVLM 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 160 IAEISPKNLRGSLGAINQLSVTTGIFLSYLGGLVLP------------WRTLALVGVApcsVLLVGLFF---IPESPrwl 224
Cdd:cd17369  130 AVEHAPPKRRGFYGSFPQLGAPVGLLLATGVFLLLSallsdeaflswgWRIPFLLSAV---LVAVGLYIrlrLEETP--- 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 225 akmgiedtlitslqalrgkdsdissEVSEIKDAVDISYKQEANVRMSDlcKKTIFLPLTITIGLLLLQQISGINAILFYS 304
Cdd:cd17369  204 -------------------------VFRRAKEAGQVVRAPLVEVLRRH--WRALLLAIGLRLAENVLFYLFTTFALSYAT 256
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 305 SAIFHSAgfSSSNLASLSLALLQVVMTGVAAVLMDRAGRRLLLMVSGAGMAVSCFlvgFAFYLqqhMDATSHFAPFVGNL 384
Cdd:cd17369  257 QTLGVDR--STVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAF---PFFWL---LDTGSTWLIVLAAV 328
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 385 ALISLLVyitsfALGMGPIPwIIMSEVLPAHIK------------GLGGSVAT-----LVNWTFSWlvtmsfnfllnWSS 447
Cdd:cd17369  329 VVLGVLH-----GMMYGPQA-AFLAELFPTRVRytgaslgyqlgaILGGGFAPliataLVAATGSW-----------WPV 391
                        410
                 ....*....|....*..
gi 302756467 448 TGSFALFAGMCAFTVLF 464
Cdd:cd17369  392 ALYLAALAVISLVAALF 408
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
72-170 8.05e-04

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 41.40  E-value: 8.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  72 KLTEDLGlSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGV 151
Cdd:cd17502   21 TIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGG 99
                         90       100
                 ....*....|....*....|..
gi 302756467 152 I---SFTVpmyIAEISPKNLRG 170
Cdd:cd17502  100 LmslAFII---IADLVPPRERG 118
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
89-216 8.32e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.43  E-value: 8.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  89 SLVNAGAMAGA-ILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKN 167
Cdd:cd17489  233 FTVYAIALLLSrPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPH 312
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 302756467 168 LRGSLGAINQLSVTTGIFL-SYLGGLVLPWRTLALVGVAPCSVLLVGLFF 216
Cdd:cd17489  313 RRGAANGTFFIFFDLGIGLgGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
73-221 1.17e-03

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 41.02  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  73 LTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVI 152
Cdd:cd17320   25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAG 104
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 302756467 153 SFTVPMYIAEI-SPKNLRGSLGAINQLSVTTGIFLSYLGGLVL---PWR----TLALVGVApcsVLLVGLFFIPESP 221
Cdd:cd17320  105 SVVARAIVRDLySGAELAKIFSLLMMILAIAPALAPLLGGLLLlffGWRaifvFLALLGLL---LLLLVLLFLPETL 178
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
59-222 1.46e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 40.62  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  59 FGFSVGYSSPTQQKLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASL 138
Cdd:cd17477    8 LGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVW 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 139 YIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSYLGGLVL---PWRTLALVGVAPCSVLLVGLF 215
Cdd:cd17477   88 FLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVgtaGALPFLIAAVLLLLALVPLLL 167

                 ....*..
gi 302756467 216 FIPESPR 222
Cdd:cd17477  168 TRRAAPE 174
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
73-219 2.04e-03

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 40.44  E-value: 2.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467   73 LTEDLGLSLSEfsmyGSLVNAGAM-AGAI---LSGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFG 148
Cdd:TIGR00711  28 IAGDLGSSLSQ----VQWVITSYMlANAIsipLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFG 103
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 302756467  149 VGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTG-IFLSYLGGLV---LPWRTLALVGVAP-CSVLLVGLFFIPE 219
Cdd:TIGR00711 104 GGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVApALGPTLGGWIienYHWRWIFLINVPIgIIVVVVAFFILPR 179
2A0111 TIGR00890
oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator ...
89-152 2.69e-03

oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator family. Members include the oxalate/formate antiporter of Oxalobacter formigenes, where one substrate is decarboxylated in the cytosol into the other to consume a proton and drive an ion gradient. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273323 [Multi-domain]  Cd Length: 377  Bit Score: 40.12  E-value: 2.69e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 302756467   89 SLVNAGAMAGAilsGRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVI 152
Cdd:TIGR00890  48 LIGLAMSMPVG---GLLADKFGPRAVAMLGGILYGLGFTFYAIADSLAALYLTYGLASAGVGIA 108
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
47-211 2.80e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 39.90  E-value: 2.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  47 FCTIVVALGPITFGFSVGYSSPTQQkLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGW 126
Cdd:cd17329  202 FLLFLLASFLISLIYFQLESTLPVY-VVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGF 280
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 127 ILNALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKNLRGSLGAINQLSVTTGIFLSYLGGLVL--------PWRT 198
Cdd:cd17329  281 AVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLldllgpglPWLI 360
                        170
                 ....*....|...
gi 302756467 199 LALVGVAPCSVLL 211
Cdd:cd17329  361 LAALGLIAAALLL 373
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
49-170 3.46e-03

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 39.66  E-value: 3.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  49 TIVVALGPITFGFSVGYsspTQQKLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGwIL 128
Cdd:cd17368  228 MLLVAGSTVTFYFTTVY---TPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVT-LY 303
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 302756467 129 NALAMNVASLYIARLLVGFGV-----GVISFTVPMYIAEISPKNLRG 170
Cdd:cd17368  304 PVFAWLTAAPSFGRLLLVLLVlsfffGMYGGAMVVALVELFPVRVRS 350
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
82-163 4.19e-03

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 39.60  E-value: 4.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467   82 SEFSMYGSLVNAGAMAGAILSGRIADRFGRKGALVIASIPHIAGWILN--ALAMNVASLYIARLLVGFGVGVISFTVPMY 159
Cdd:pfam13347 259 FAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALAllLGPNNTLLFLVLYIIIGFGYGSSFFLPWSM 338

                  ....
gi 302756467  160 IAEI 163
Cdd:pfam13347 339 LADV 342
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
72-220 4.47e-03

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 39.16  E-value: 4.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  72 KLTEDLGLSLSEFSM-YGSLVNAGAMAGAILS---GRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGF 147
Cdd:cd17388   24 TLLREFVGDSADAAThYGVLLALYALMQFIFApilGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGI 103
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 302756467 148 GVGviSFTVPM-YIAEISPKNLR----GSLGAINQLSVTTGIFLSYLGGLVLPwRTLALVGVAPCSV-LLVGLFFIPES 220
Cdd:cd17388  104 TGA--TGAVAAaYIADVTPPEQRarnfGLLGAAFGLGFIAGPALGGLLGEISP-RAPFLVAAGLNGLnFLLGLFVLPES 179
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
89-229 5.15e-03

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 38.88  E-value: 5.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  89 SLVNAGAMAGAILSGRIAD-RFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISPKN 167
Cdd:cd17378   40 SSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLATEPVGPK 119
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 302756467 168 LRGSLGAINQLSVTTGIF----LSYLGGlvLPWRTLALVGVAPCSVLLVGLFFIPEspRWLAKMGI 229
Cdd:cd17378  120 WRGQVGMSTFFFFVLGFMslpgIAYLNG--SSWRVLYFWTSIPALIYCILVYLFAR--RLLAVMVI 181
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
50-222 7.23e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 38.74  E-value: 7.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  50 IVVALgpitFGFSVGYSSPTQQKLTEDLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFG-RKGALVIASIPHIAGWIL 128
Cdd:cd17490    3 IIVFL----FWFSQYVYVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467 129 NALAMNVASLYIARLLVGFGVGV-ISFTVpMYIAEISPKNLRGSLGAINQLSVTTGIFLSYLGGLV---LPWRTLALVGV 204
Cdd:cd17490   79 MILFPSPWGLLIARFLSGIAAATwVSFTV-LYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIaehFGMRAPFLLAA 157
                        170
                 ....*....|....*...
gi 302756467 205 APCSVLLVGLFFIPESPR 222
Cdd:cd17490  158 LAGVLGFILSLFIKEERR 175
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
76-220 7.35e-03

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 38.46  E-value: 7.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  76 DLGLSLSEFSMYGSLVNAGAMAGAILSGRIADRFGRKG-ALVIASIPHIAGWiLNALAMNVASLYIARLLVGFGVG---V 151
Cdd:PRK10473  32 DLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPvAIPGAALFIIASL-LCSLAETSSLFLAGRFLQGIGAGccyV 110
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 302756467 152 ISFTVPMYIaeISPKNLRGSLGAINQLSVTTGIFLSYLGGLVL---PWR----TLALVGVApcsVLLVGLFFIPES 220
Cdd:PRK10473 111 VAFAILRDT--LDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMlkfPWQslfyTMAAMGIL---VLLLSLFILKET 181
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
90-217 7.36e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 38.78  E-value: 7.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302756467  90 LVNAGAMAGAILS----GRIADRFGRKGALVIASIPHIAGWILNALAMNVASLYIARLLVGFGVGVISFTVPMYIAEISP 165
Cdd:cd17391  244 LVFSATGVSSLLSaprlGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITP 323
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 302756467 166 KNLRGSLGAINQLSVTTGIFL-SYLGGLVLPWRTLALVGVAPCSVLLVGLFFI 217
Cdd:cd17391  324 KEVAGRIFGYNQSFQYLGNVAgPLLGSAIAAHFGYRAVFVVTALLVLLNAIWS 376
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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