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Conserved domains on  [gi|301117212|ref|XP_002906334|]
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uncharacterized protein PITG_03259 [Phytophthora infestans T30-4]

Protein Classification

WW domain-containing protein( domain architecture ID 10449603)

WW domain-containing protein; the WW domain mediates protein-protein interaction via proline-rich motifs, such as PPxY

CATH:  2.20.70.10
Gene Ontology:  GO:0005515
PubMed:  22201747|9029943|7641887

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 237-263 5.27e-06

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


:

Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 42.49  E-value: 5.27e-06
                          10        20
                  ....*....|....*....|....*..
gi 301117212  237 WQQHVDAQtQRYYYHNVVTGVTQWNKP 263
Cdd:pfam00397   5 WEERWDPD-GRVYYYNHETGETQWEKP 30
PRP40 super family cl34905
Splicing factor [RNA processing and modification];
12-116 9.59e-05

Splicing factor [RNA processing and modification];


The actual alignment was detected with superfamily member COG5104:

Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 44.30  E-value: 9.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301117212  12 AEWEKhVDEATGSMDYYNARTDESSWEVPAGFNSPQKEDASQDkapKWLEFVDDEsGATYYFDKMSGTSRWDKPDDFIPE 91
Cdd:COG5104   15 SEWEE-LKAPDGRIYYYNKRTGKSSWEKPKELLKGSEEDLDVD---PWKECRTAD-GKVYYYNSITRESRWKIPPERKKV 89

                         90       100
                 ....*....|....*....|....*
gi 301117212  92 QESRDQEKYKKTEKQEEDDEKKTKD 116
Cdd:COG5104   90 EPIAEQKHDERSMIGGNGNDMAITD 114
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 130-156 2.83e-04

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


:

Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 37.87  E-value: 2.83e-04
                          10        20
                  ....*....|....*....|....*..
gi 301117212  130 WVKYVDAaSNKPYFHDASTGKTQWEEP 156
Cdd:pfam00397   5 WEERWDP-DGRVYYYNHETGETQWEKP 30
 
Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 237-263 5.27e-06

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 42.49  E-value: 5.27e-06
                          10        20
                  ....*....|....*....|....*..
gi 301117212  237 WQQHVDAQtQRYYYHNVVTGVTQWNKP 263
Cdd:pfam00397   5 WEERWDPD-GRVYYYNHETGETQWEKP 30
PRP40 COG5104
Splicing factor [RNA processing and modification];
12-116 9.59e-05

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 44.30  E-value: 9.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301117212  12 AEWEKhVDEATGSMDYYNARTDESSWEVPAGFNSPQKEDASQDkapKWLEFVDDEsGATYYFDKMSGTSRWDKPDDFIPE 91
Cdd:COG5104   15 SEWEE-LKAPDGRIYYYNKRTGKSSWEKPKELLKGSEEDLDVD---PWKECRTAD-GKVYYYNSITRESRWKIPPERKKV 89

                         90       100
                 ....*....|....*....|....*
gi 301117212  92 QESRDQEKYKKTEKQEEDDEKKTKD 116
Cdd:COG5104   90 EPIAEQKHDERSMIGGNGNDMAITD 114
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 130-156 2.83e-04

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 37.87  E-value: 2.83e-04
                          10        20
                  ....*....|....*....|....*..
gi 301117212  130 WVKYVDAaSNKPYFHDASTGKTQWEEP 156
Cdd:pfam00397   5 WEERWDP-DGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 130-158 1.11e-03

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 35.97  E-value: 1.11e-03
                         10        20
                 ....*....|....*....|....*....
gi 301117212 130 WVKYVDAaSNKPYFHDASTGKTQWEEPED 158
Cdd:cd00201    4 WEERWDP-DGRVYYYNHNTKETQWEDPRE 31
PLN02381 PLN02381
valyl-tRNA synthetase
 80-167 1.61e-03

valyl-tRNA synthetase


Pssm-ID: 215214 [Multi-domain]  Cd Length: 1066  Bit Score: 40.65  E-value: 1.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301117212   80 SRWDKPDDFIPEQESRDQEKYKKTEKQEEDDEKKTKDAleDNAADAKAQHWVKYVDAASNKPYFHDASTGKTQWEEPEDF 159
Cdd:PLN02381    2 SRTESEAEKKILTEEELERKKKKEEKAKEKELKKLKAA--QKEAKAKLQAQQASDGTNVPKKSEKKSRKRDVEDENPEDF 79


                  ....*...
gi 301117212  160 EEPATPVG 167
Cdd:PLN02381   80 IDPDTPFG 87
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 57-85 1.71e-03

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 35.56  E-value: 1.71e-03
                          10        20
                  ....*....|....*....|....*....
gi 301117212   57 PKWLEFVDDEsGATYYFDKMSGTSRWDKP 85
Cdd:pfam00397   3 PGWEERWDPD-GRVYYYNHETGETQWEKP 30
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 130-158 2.35e-03

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 35.27  E-value: 2.35e-03
                           10        20
                   ....*....|....*....|....*....
gi 301117212   130 WVKYVDAaSNKPYFHDASTGKTQWEEPED 158
Cdd:smart00456   6 WEERKDP-DGRPYYYNHETKETQWEKPRE 33
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 57-87 5.78e-03

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 34.04  E-value: 5.78e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 301117212  57 PKWLEFVDdESGATYYFDKMSGTSRWDKPDD 87
Cdd:cd00201    2 PGWEERWD-PDGRVYYYNHNTKETQWEDPRE 31
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 237-263 6.77e-03

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 34.04  E-value: 6.77e-03
                         10        20
                 ....*....|....*....|....*..
gi 301117212 237 WQQHVDAQtQRYYYHNVVTGVTQWNKP 263
Cdd:cd00201    4 WEERWDPD-GRVYYYNHNTKETQWEDP 29
 
Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 237-263 5.27e-06

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 42.49  E-value: 5.27e-06
                          10        20
                  ....*....|....*....|....*..
gi 301117212  237 WQQHVDAQtQRYYYHNVVTGVTQWNKP 263
Cdd:pfam00397   5 WEERWDPD-GRVYYYNHETGETQWEKP 30
PRP40 COG5104
Splicing factor [RNA processing and modification];
12-116 9.59e-05

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 44.30  E-value: 9.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301117212  12 AEWEKhVDEATGSMDYYNARTDESSWEVPAGFNSPQKEDASQDkapKWLEFVDDEsGATYYFDKMSGTSRWDKPDDFIPE 91
Cdd:COG5104   15 SEWEE-LKAPDGRIYYYNKRTGKSSWEKPKELLKGSEEDLDVD---PWKECRTAD-GKVYYYNSITRESRWKIPPERKKV 89

                         90       100
                 ....*....|....*....|....*
gi 301117212  92 QESRDQEKYKKTEKQEEDDEKKTKD 116
Cdd:COG5104   90 EPIAEQKHDERSMIGGNGNDMAITD 114
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 130-156 2.83e-04

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 37.87  E-value: 2.83e-04
                          10        20
                  ....*....|....*....|....*..
gi 301117212  130 WVKYVDAaSNKPYFHDASTGKTQWEEP 156
Cdd:pfam00397   5 WEERWDP-DGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 130-158 1.11e-03

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 35.97  E-value: 1.11e-03
                         10        20
                 ....*....|....*....|....*....
gi 301117212 130 WVKYVDAaSNKPYFHDASTGKTQWEEPED 158
Cdd:cd00201    4 WEERWDP-DGRVYYYNHNTKETQWEDPRE 31
PLN02381 PLN02381
valyl-tRNA synthetase
 80-167 1.61e-03

valyl-tRNA synthetase


Pssm-ID: 215214 [Multi-domain]  Cd Length: 1066  Bit Score: 40.65  E-value: 1.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301117212   80 SRWDKPDDFIPEQESRDQEKYKKTEKQEEDDEKKTKDAleDNAADAKAQHWVKYVDAASNKPYFHDASTGKTQWEEPEDF 159
Cdd:PLN02381    2 SRTESEAEKKILTEEELERKKKKEEKAKEKELKKLKAA--QKEAKAKLQAQQASDGTNVPKKSEKKSRKRDVEDENPEDF 79


                  ....*...
gi 301117212  160 EEPATPVG 167
Cdd:PLN02381   80 IDPDTPFG 87
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 57-85 1.71e-03

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 35.56  E-value: 1.71e-03
                          10        20
                  ....*....|....*....|....*....
gi 301117212   57 PKWLEFVDDEsGATYYFDKMSGTSRWDKP 85
Cdd:pfam00397   3 PGWEERWDPD-GRVYYYNHETGETQWEKP 30
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 130-158 2.35e-03

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 35.27  E-value: 2.35e-03
                           10        20
                   ....*....|....*....|....*....
gi 301117212   130 WVKYVDAaSNKPYFHDASTGKTQWEEPED 158
Cdd:smart00456   6 WEERKDP-DGRPYYYNHETKETQWEKPRE 33
PRP40 COG5104
Splicing factor [RNA processing and modification];
51-206 5.33e-03

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 38.91  E-value: 5.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301117212  51 ASQDKAPKWLEfVDDESGATYYFDKMSGTSRWDKPDDFIpeqesrdqekykkteKQEEDDekktkdaLEDNAadakaqhW 130
Cdd:COG5104    9 ASGEARSEWEE-LKAPDGRIYYYNKRTGKSSWEKPKELL---------------KGSEED-------LDVDP-------W 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301117212 131 VKYvDAASNKPYFHDASTGKTQWEEPeDFEEPATPVGTQVSAEY--------HAHLKRMQTEHLARVTQQVLDPSGNLSK 202
Cdd:COG5104   59 KEC-RTADGKVYYYNSITRESRWKIP-PERKKVEPIAEQKHDERsmiggngnDMAITDHETSEPKYLLGRLMSQYGITST 136


                 ....
gi 301117212 203 LNAI 206
Cdd:COG5104  137 KDAV 140
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 57-87 5.78e-03

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 34.04  E-value: 5.78e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 301117212  57 PKWLEFVDdESGATYYFDKMSGTSRWDKPDD 87
Cdd:cd00201    2 PGWEERWD-PDGRVYYYNHNTKETQWEDPRE 31
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 237-263 6.77e-03

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 34.04  E-value: 6.77e-03
                         10        20
                 ....*....|....*....|....*..
gi 301117212 237 WQQHVDAQtQRYYYHNVVTGVTQWNKP 263
Cdd:cd00201    4 WEERWDPD-GRVYYYNHNTKETQWEDP 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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