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Conserved domains on  [gi|297792523|ref|XP_002864146|]
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traB domain-containing protein isoform X3 [Arabidopsis lyrata subsp. lyrata]

Protein Classification

TraB domain-containing protein( domain architecture ID 12999407)

TraB domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TraB_PrgY-like cd14726
TraB/PryY confer plasmid-borne pheromone resistance; TraB/PrgY proteins, identified in gut ...
95-340 6.81e-51

TraB/PryY confer plasmid-borne pheromone resistance; TraB/PrgY proteins, identified in gut bacterium Enterococcus faecalis, are plasmid-borne homologs that are induced by pheromones. Induction rends the host bacterium insensitive to self-induction by its own pheromones, and prevents the transfer of the pheromone-inducible conjugative plasmids to bacteria that already contain it. Based on homology to Tiki activity, it has been proposed that TraB acts as a protease in the inactivation of mating pheromone, cleaving at the amino-terminus. The pheromones are small peptides (7-8 residues) encoded by the bacterial genome, and are specific for particular plasmids, or class of plasmids, which may contain several virulence factors and disseminate rapidly. Plasmid-borne antibiotic resistance and virulence determinants make these elements important contributors to medical problems. Trab/PrygY is a member of a Tiki-like superfamily. Tiki is a membrane-associated metalloprotease (MEROPS family M96) that inhibits Wnt via the cleavage of its amino terminus. Wnt is essential in animal development and homeostasis. In Xenopus, Tiki is critical in head development. In human cells, Tiki inhibits Wnt-signaling. Tiki proteins are also related to erythromycin esterase, gumN plant pathogens, RtxA containing toxins, and Campylobacter Jejuni ChaN heme-binding protein.


:

Pssm-ID: 350608  Cd Length: 177  Bit Score: 168.91  E-value: 6.81e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523  95 IWLVGTSHISPESASVVERVVRTVKPDNVAVELCRSRkvhffiqlklgAGIMytssVGGEVDQNLKSGVLSLTGTGFLGA 174
Cdd:cd14726    1 VYLVGTAHVSKESAEEVREVIREVKPDVVAVELCESR-----------YEAL----LDPERWKNTDIKKVIKEKKGFLLL 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523 175 VGRSLdlggqtalalrlllAVFSSKLSSVADRPFGDEFRAARKASEEVGAQLVLGDRPIEITLQRAWNSLKWgekfnlvm 254
Cdd:cd14726   66 ANLLL--------------SSFQKKIGKELGVKPGAEFRAAIEEAEEVGAPVVLGDRDIQITLKRAWDVLEE-------- 123
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523 255 avtraitsssgisaaelkeqetdesngslqLYERLSFSYPSLLLPLIHERDTYLAWSLKRSKAvnGCKTVVGVIGKGHMN 334
Cdd:cd14726  124 ------------------------------LLSELAEEFPELKEVLIDERDQYLAHSLRRAAA--GGKKVVAVVGAGHVP 171

                 ....*.
gi 297792523 335 GVIYAL 340
Cdd:cd14726  172 GIERLL 177
 
Name Accession Description Interval E-value
TraB_PrgY-like cd14726
TraB/PryY confer plasmid-borne pheromone resistance; TraB/PrgY proteins, identified in gut ...
95-340 6.81e-51

TraB/PryY confer plasmid-borne pheromone resistance; TraB/PrgY proteins, identified in gut bacterium Enterococcus faecalis, are plasmid-borne homologs that are induced by pheromones. Induction rends the host bacterium insensitive to self-induction by its own pheromones, and prevents the transfer of the pheromone-inducible conjugative plasmids to bacteria that already contain it. Based on homology to Tiki activity, it has been proposed that TraB acts as a protease in the inactivation of mating pheromone, cleaving at the amino-terminus. The pheromones are small peptides (7-8 residues) encoded by the bacterial genome, and are specific for particular plasmids, or class of plasmids, which may contain several virulence factors and disseminate rapidly. Plasmid-borne antibiotic resistance and virulence determinants make these elements important contributors to medical problems. Trab/PrygY is a member of a Tiki-like superfamily. Tiki is a membrane-associated metalloprotease (MEROPS family M96) that inhibits Wnt via the cleavage of its amino terminus. Wnt is essential in animal development and homeostasis. In Xenopus, Tiki is critical in head development. In human cells, Tiki inhibits Wnt-signaling. Tiki proteins are also related to erythromycin esterase, gumN plant pathogens, RtxA containing toxins, and Campylobacter Jejuni ChaN heme-binding protein.


Pssm-ID: 350608  Cd Length: 177  Bit Score: 168.91  E-value: 6.81e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523  95 IWLVGTSHISPESASVVERVVRTVKPDNVAVELCRSRkvhffiqlklgAGIMytssVGGEVDQNLKSGVLSLTGTGFLGA 174
Cdd:cd14726    1 VYLVGTAHVSKESAEEVREVIREVKPDVVAVELCESR-----------YEAL----LDPERWKNTDIKKVIKEKKGFLLL 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523 175 VGRSLdlggqtalalrlllAVFSSKLSSVADRPFGDEFRAARKASEEVGAQLVLGDRPIEITLQRAWNSLKWgekfnlvm 254
Cdd:cd14726   66 ANLLL--------------SSFQKKIGKELGVKPGAEFRAAIEEAEEVGAPVVLGDRDIQITLKRAWDVLEE-------- 123
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523 255 avtraitsssgisaaelkeqetdesngslqLYERLSFSYPSLLLPLIHERDTYLAWSLKRSKAvnGCKTVVGVIGKGHMN 334
Cdd:cd14726  124 ------------------------------LLSELAEEFPELKEVLIDERDQYLAHSLRRAAA--GGKKVVAVVGAGHVP 171

                 ....*.
gi 297792523 335 GVIYAL 340
Cdd:cd14726  172 GIERLL 177
COG1916 COG1916
Pheromone shutdown protein TraB, contains GTxH motif (function unknown) [Function unknown];
95-353 1.04e-39

Pheromone shutdown protein TraB, contains GTxH motif (function unknown) [Function unknown];


Pssm-ID: 441520  Cd Length: 392  Bit Score: 145.71  E-value: 1.04e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523  95 IWLVGTSHISPESASVVERVVRTVKPDNVAVELCRSRkvhffiqlklgagimYTSSVGGEVDQN------LKSG-VLSLT 167
Cdd:COG1916   16 IILLGTAHVSQESVEEVREVIEEEKPDAVAVELDESR---------------YQALKDPDAWKDldifkvIKEGkAGLLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523 168 GTGFLGAVGRSLdlGGQTALalrlllavfssklssvadRPfGDEFRAARKASEEVGAQLVLGDRPIEITLQRAWNSLKWG 247
Cdd:COG1916   81 ANLALSAFQKRL--GEQFGI------------------EP-GAEMKAAIEAAEERGAPVALIDRDIQITLKRAWRNMGFW 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523 248 EKFNLVMAVTRAITSSSGISAAE---LKEQETDESngslqLYERLSFSYPSLLLPLIHERDTYLAWSLKRskAVNGCKTV 324
Cdd:COG1916  140 EKLKLLAGLIASLFSREEISEEEiekLKEGDVLEA-----LFEEFAEFSPKLKEVLIDERDAYLAHKLRE--APARGKKV 212
                        250       260
                 ....*....|....*....|....*....
gi 297792523 325 VGVIGKGHMNGVIYALVSDSGDLRFKDLV 353
Cdd:COG1916  213 VAVVGAGHLPGIERYLEEPETLPDLAELE 241
traB TIGR00261
pheromone shutdown-related protein TraB; traB is a plasmid encoded gene that functions in the ...
90-340 8.80e-18

pheromone shutdown-related protein TraB; traB is a plasmid encoded gene that functions in the shutdown of the peptide sex pheromone cPD1 which is produced by the plasmid free recipient cell prior to conjugative transfer in Enterococcus faecalis. Once the recipient acquires the plasmid, production of cPD1 is shut down. The gene product may play another role in the other species in the family. [Unknown function, General]


Pssm-ID: 129363  Cd Length: 380  Bit Score: 84.13  E-value: 8.80e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523   90 VEPEAIWLVGTSHISPESASVVERVVRTVKPDNVAVELCRSRkvhFFiqlklgaGIMYTSSVGGEVDQNLKSG-----VL 164
Cdd:TIGR00261   1 IHEKTIYILGTAHVSKKSSEEVANLIEILKPDYIAVELDERR---YH-------SLLNTKWRNLDIDKVLKQGnafflII 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523  165 SLTGTGFLGAVGRSLDLggqtalalrlllavfssklssvadRPfGDEFRAARKASEEVGAQLVLGDRPIEITLQRAWNSL 244
Cdd:TIGR00261  71 NLILANFQKKLGEEQGI------------------------KP-GSEMKTAIEKAKKHGIPLILIDRDIETTLKRAWISI 125
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523  245 KWGEKFNLVMAVTRAITSSSGISAAELKEQETDEsngslQLYERLSFSYPSLLLPLIHERDTYLAWSLkrSKAVNGCKTV 324
Cdd:TIGR00261 126 TFFEKAKIISSLFSSTDAKIEDEIEKLLEQDALS-----KIMKELSKISPKVKKVLIDERDEFMANKL--LEGEGNKNII 198
                         250
                  ....*....|....*.
gi 297792523  325 VGVIGKGHMNGVIYAL 340
Cdd:TIGR00261 199 VAVVGAGHVSGIMRTL 214
TraB_PrgY_gumN pfam01963
TraB/PrgY/gumN family; This entry includes Tiki1/2 from humans, TraB/PrgY from the gut flora ...
91-335 3.38e-14

TraB/PrgY/gumN family; This entry includes Tiki1/2 from humans, TraB/PrgY from the gut flora Enterococcusfaecalis and gumN from the plant pathogen Xanthomonas. Tiki1 is homologous to TraB/PrgY. They have a pair of widely spaced GX2H motifs and a conserved glutamate. From the structural study, this group of proteins have been identified as an ancient metalloprotease clan with a common protein architecture (cobbled from the folds of the EreA/ChaN/PMT group) that mediates proteolytic activities. Tiki1 is a membrane-associated protease that inhibits Wnt via the cleavage of its amino terminus, diminishing Wnt's binding to receptors. TraB/PrgY is an inhibitor peptide that may act as a protease to inactivate the mating pheromone.


Pssm-ID: 426534  Cd Length: 262  Bit Score: 72.00  E-value: 3.38e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523   91 EPEAIWLVGTSHISPESASVVERVVRTV--KPDNVAVELCRSRKVHFFIQLKLGAGIMYTSsvGGEVDQNLKSGVLSLtg 168
Cdd:pfam01963   8 GGTTVYLLGTIHVLPPSVYPLPPAIEEAleAADTVVVELDLSRYTDPATQAALPKLGLLPD--GKTLSDLLSPELYAR-- 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523  169 tgfLGAVGRSLDLGGQTALALrlllavfssklssvadRPF--GDEFRAARKASEEVGAQLVLGDRPIEITLQRAWNSLKW 246
Cdd:pfam01963  84 ---LQKALAKRGLPLAALDRM----------------KPWlaALLLSLAELAKQKAGLDPDLVDRYLAKTAKRAGKPVGG 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523  247 GEKFNLVMAVtraITSSSGISAAELKE--QETDESN---------------GSLQLYERLSFSYPSLLLPLIHERDTYLA 309
Cdd:pfam01963 145 LETVEEQLAL---LSLPDEEQLEMLEEtlDELEKGEdlletlveawaegdlEALELEAELKEAYPELYEVLLDERNRYWA 221
                         250       260
                  ....*....|....*....|....*.
gi 297792523  310 WSLKrsKAVNGCKTVVGVIGKGHMNG 335
Cdd:pfam01963 222 EKIE--ALLKEGGTVFVAVGAGHLPG 245
 
Name Accession Description Interval E-value
TraB_PrgY-like cd14726
TraB/PryY confer plasmid-borne pheromone resistance; TraB/PrgY proteins, identified in gut ...
95-340 6.81e-51

TraB/PryY confer plasmid-borne pheromone resistance; TraB/PrgY proteins, identified in gut bacterium Enterococcus faecalis, are plasmid-borne homologs that are induced by pheromones. Induction rends the host bacterium insensitive to self-induction by its own pheromones, and prevents the transfer of the pheromone-inducible conjugative plasmids to bacteria that already contain it. Based on homology to Tiki activity, it has been proposed that TraB acts as a protease in the inactivation of mating pheromone, cleaving at the amino-terminus. The pheromones are small peptides (7-8 residues) encoded by the bacterial genome, and are specific for particular plasmids, or class of plasmids, which may contain several virulence factors and disseminate rapidly. Plasmid-borne antibiotic resistance and virulence determinants make these elements important contributors to medical problems. Trab/PrygY is a member of a Tiki-like superfamily. Tiki is a membrane-associated metalloprotease (MEROPS family M96) that inhibits Wnt via the cleavage of its amino terminus. Wnt is essential in animal development and homeostasis. In Xenopus, Tiki is critical in head development. In human cells, Tiki inhibits Wnt-signaling. Tiki proteins are also related to erythromycin esterase, gumN plant pathogens, RtxA containing toxins, and Campylobacter Jejuni ChaN heme-binding protein.


Pssm-ID: 350608  Cd Length: 177  Bit Score: 168.91  E-value: 6.81e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523  95 IWLVGTSHISPESASVVERVVRTVKPDNVAVELCRSRkvhffiqlklgAGIMytssVGGEVDQNLKSGVLSLTGTGFLGA 174
Cdd:cd14726    1 VYLVGTAHVSKESAEEVREVIREVKPDVVAVELCESR-----------YEAL----LDPERWKNTDIKKVIKEKKGFLLL 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523 175 VGRSLdlggqtalalrlllAVFSSKLSSVADRPFGDEFRAARKASEEVGAQLVLGDRPIEITLQRAWNSLKWgekfnlvm 254
Cdd:cd14726   66 ANLLL--------------SSFQKKIGKELGVKPGAEFRAAIEEAEEVGAPVVLGDRDIQITLKRAWDVLEE-------- 123
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523 255 avtraitsssgisaaelkeqetdesngslqLYERLSFSYPSLLLPLIHERDTYLAWSLKRSKAvnGCKTVVGVIGKGHMN 334
Cdd:cd14726  124 ------------------------------LLSELAEEFPELKEVLIDERDQYLAHSLRRAAA--GGKKVVAVVGAGHVP 171

                 ....*.
gi 297792523 335 GVIYAL 340
Cdd:cd14726  172 GIERLL 177
COG1916 COG1916
Pheromone shutdown protein TraB, contains GTxH motif (function unknown) [Function unknown];
95-353 1.04e-39

Pheromone shutdown protein TraB, contains GTxH motif (function unknown) [Function unknown];


Pssm-ID: 441520  Cd Length: 392  Bit Score: 145.71  E-value: 1.04e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523  95 IWLVGTSHISPESASVVERVVRTVKPDNVAVELCRSRkvhffiqlklgagimYTSSVGGEVDQN------LKSG-VLSLT 167
Cdd:COG1916   16 IILLGTAHVSQESVEEVREVIEEEKPDAVAVELDESR---------------YQALKDPDAWKDldifkvIKEGkAGLLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523 168 GTGFLGAVGRSLdlGGQTALalrlllavfssklssvadRPfGDEFRAARKASEEVGAQLVLGDRPIEITLQRAWNSLKWG 247
Cdd:COG1916   81 ANLALSAFQKRL--GEQFGI------------------EP-GAEMKAAIEAAEERGAPVALIDRDIQITLKRAWRNMGFW 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523 248 EKFNLVMAVTRAITSSSGISAAE---LKEQETDESngslqLYERLSFSYPSLLLPLIHERDTYLAWSLKRskAVNGCKTV 324
Cdd:COG1916  140 EKLKLLAGLIASLFSREEISEEEiekLKEGDVLEA-----LFEEFAEFSPKLKEVLIDERDAYLAHKLRE--APARGKKV 212
                        250       260
                 ....*....|....*....|....*....
gi 297792523 325 VGVIGKGHMNGVIYALVSDSGDLRFKDLV 353
Cdd:COG1916  213 VAVVGAGHLPGIERYLEEPETLPDLAELE 241
traB TIGR00261
pheromone shutdown-related protein TraB; traB is a plasmid encoded gene that functions in the ...
90-340 8.80e-18

pheromone shutdown-related protein TraB; traB is a plasmid encoded gene that functions in the shutdown of the peptide sex pheromone cPD1 which is produced by the plasmid free recipient cell prior to conjugative transfer in Enterococcus faecalis. Once the recipient acquires the plasmid, production of cPD1 is shut down. The gene product may play another role in the other species in the family. [Unknown function, General]


Pssm-ID: 129363  Cd Length: 380  Bit Score: 84.13  E-value: 8.80e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523   90 VEPEAIWLVGTSHISPESASVVERVVRTVKPDNVAVELCRSRkvhFFiqlklgaGIMYTSSVGGEVDQNLKSG-----VL 164
Cdd:TIGR00261   1 IHEKTIYILGTAHVSKKSSEEVANLIEILKPDYIAVELDERR---YH-------SLLNTKWRNLDIDKVLKQGnafflII 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523  165 SLTGTGFLGAVGRSLDLggqtalalrlllavfssklssvadRPfGDEFRAARKASEEVGAQLVLGDRPIEITLQRAWNSL 244
Cdd:TIGR00261  71 NLILANFQKKLGEEQGI------------------------KP-GSEMKTAIEKAKKHGIPLILIDRDIETTLKRAWISI 125
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523  245 KWGEKFNLVMAVTRAITSSSGISAAELKEQETDEsngslQLYERLSFSYPSLLLPLIHERDTYLAWSLkrSKAVNGCKTV 324
Cdd:TIGR00261 126 TFFEKAKIISSLFSSTDAKIEDEIEKLLEQDALS-----KIMKELSKISPKVKKVLIDERDEFMANKL--LEGEGNKNII 198
                         250
                  ....*....|....*.
gi 297792523  325 VGVIGKGHMNGVIYAL 340
Cdd:TIGR00261 199 VAVVGAGHVSGIMRTL 214
TraB_PrgY_gumN pfam01963
TraB/PrgY/gumN family; This entry includes Tiki1/2 from humans, TraB/PrgY from the gut flora ...
91-335 3.38e-14

TraB/PrgY/gumN family; This entry includes Tiki1/2 from humans, TraB/PrgY from the gut flora Enterococcusfaecalis and gumN from the plant pathogen Xanthomonas. Tiki1 is homologous to TraB/PrgY. They have a pair of widely spaced GX2H motifs and a conserved glutamate. From the structural study, this group of proteins have been identified as an ancient metalloprotease clan with a common protein architecture (cobbled from the folds of the EreA/ChaN/PMT group) that mediates proteolytic activities. Tiki1 is a membrane-associated protease that inhibits Wnt via the cleavage of its amino terminus, diminishing Wnt's binding to receptors. TraB/PrgY is an inhibitor peptide that may act as a protease to inactivate the mating pheromone.


Pssm-ID: 426534  Cd Length: 262  Bit Score: 72.00  E-value: 3.38e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523   91 EPEAIWLVGTSHISPESASVVERVVRTV--KPDNVAVELCRSRKVHFFIQLKLGAGIMYTSsvGGEVDQNLKSGVLSLtg 168
Cdd:pfam01963   8 GGTTVYLLGTIHVLPPSVYPLPPAIEEAleAADTVVVELDLSRYTDPATQAALPKLGLLPD--GKTLSDLLSPELYAR-- 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523  169 tgfLGAVGRSLDLGGQTALALrlllavfssklssvadRPF--GDEFRAARKASEEVGAQLVLGDRPIEITLQRAWNSLKW 246
Cdd:pfam01963  84 ---LQKALAKRGLPLAALDRM----------------KPWlaALLLSLAELAKQKAGLDPDLVDRYLAKTAKRAGKPVGG 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297792523  247 GEKFNLVMAVtraITSSSGISAAELKE--QETDESN---------------GSLQLYERLSFSYPSLLLPLIHERDTYLA 309
Cdd:pfam01963 145 LETVEEQLAL---LSLPDEEQLEMLEEtlDELEKGEdlletlveawaegdlEALELEAELKEAYPELYEVLLDERNRYWA 221
                         250       260
                  ....*....|....*....|....*.
gi 297792523  310 WSLKrsKAVNGCKTVVGVIGKGHMNG 335
Cdd:pfam01963 222 EKIE--ALLKEGGTVFVAVGAGHLPG 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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