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Conserved domains on  [gi|1622869999|ref|XP_002799978|]
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sarcosine dehydrogenase, mitochondrial isoform X2 [Macaca mulatta]

Protein Classification

FAD-dependent oxidoreductase( domain architecture ID 11429831)

FAD-dependent oxidoreductase containing a GcvT (glycine cleavage system T) domain such as sarcosine dehydrogenase and dimethylglycine dehydrogenase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 480-916 4.34e-106

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


:

Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 333.20  E-value: 4.34e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 480 GRNMRRDPLHEELLGQGCVFQERHGWERPGWFHpqgpapvleydyygaygsrphedyayrrlladeytfdfpphhDTIKK 559
Cdd:COG0404     1 FRPLRRTPLHDRHVALGAKFVDFGGWEMPVQYP------------------------------------------GGVIA 38

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 560 ECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADVSR-PPGSTVYTCMLNHRGGTESDLTVSRLAPshqasplapa 638
Cdd:COG0404    39 EHLAVREAVGLFDVSHMGKIEVTGPDAAAFLDRLVTNDVSKlKPGRARYTLMLNEDGGIIDDLTVYRLGE---------- 108

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 639 fegDGYYLAVGGAVAQHNWSHITTVLQDQkFQCQLIDSSEDLGMVSIQGPASRAILQEVLDADLSneAFPFSTHKLLRAA 718
Cdd:COG0404   109 ---DRFLLVVNAANAAKDLAWLEEHLPPD-FDVTITDVTDDWALLAVQGPKAREVLAKLTDADLS--ALPFMSFREGTVA 182

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 719 GHLVRAMRLSFVGELGWELHIPKVSCVPVYRAVMAAGAKHGLVNAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFT 798
Cdd:COG0404   183 GVPVRVSRTGYTGEDGFEIYVPAEDAEALWDALLEAGEEFGVKPCGLGARDTLRLEAGYPLYGHELDETTTPLEAGLGWA 262

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 799 CKLKSPvPFLGREALEQQRAAGLRRRLVCFTVEDKVPMFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYIHDpsggpv 878
Cdd:COG0404   263 VKLDKG-DFIGKEALLRQKEEGPRRKLVGLELDGRGVPRAGAPVLADGEVVGEVTSGTFSPTLGKSIALAYVPA------ 335

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1622869999 879 slDFVKSGD-YALERMGVTYGARAHLKSPFDPDNKRVKG 916
Cdd:COG0404   336 --GLARPGTeLEVEIRGKRVPAEVVKPPFYDPEGERLRG 372
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
66-444 5.86e-85

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


:

Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 276.79  E-value: 5.86e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999  66 TANVVVIGGGSLGCQTLYHLAKLGMSgAVLLERERLTSGTTWHTAGLLWQLRPSDVEVELLAHTRRVVS--RELEEETGL 143
Cdd:COG0665     2 TADVVVIGGGIAGLSTAYHLARRGLD-VTVLERGRPGSGASGRNAGQLRPGLAALADRALVRLAREALDlwRELAAELGI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 144 HTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCSTLARA 223
Cdd:COG0665    81 DCDFRRTGVLYLARTEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLYDPDDGHVDPAKLVRALARA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 224 ASARGAQVIENCPVTGIRVwTDDfgvrRVAGVETPHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTERIEG 303
Cdd:COG0665   161 ARAAGVRIREGTPVTGLER-EGG----RVTGVRTERGTVRADAVVLAAGAWSARLLPMLGLRLPLRPVRGYVLVTEPLPD 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 304 IQNMPNVRDHDasVYLRLQGD-ALSVGGyeanpifweevSDKFAFGLFDLDWEVFTQHIEGAINRVPVLEKTGIKSTVCG 382
Cdd:COG0665   236 LPLRPVLDDTG--VYLRPTADgRLLVGG-----------TAEPAGFDRAPTPERLEALLRRLRRLFPALADAEIVRAWAG 302

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622869999 383 PESFTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRR 444
Cdd:COG0665   303 LRPMTPDGLPIIGRLPGAPGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPDR 364
FAO_M pfam16350
FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent ...
 430-485 2.99e-21

FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent oxidoreductases: Sarcosine dehydrogenase, Dimethylglycine dehydrogenase and Dimethylglycine dehydrogenase. It is situated between the DAO domain (pfam01266) and the GCV_T domain (pfam01571).


:

Pssm-ID: 465100  Cd Length: 56  Bit Score: 87.51  E-value: 2.99e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622869999 430 HGRPEKDMHGYDIRRFHHsLTDHPRWIRERSHESYAKNYSVVFPHDEPLAGRNMRR 485
Cdd:pfam16350   1 DGEPPIDLWECDIRRFGP-HQNNREYLRERVAENYGEVYDIHHPNEEREAGRPLRT 55
 
Name Accession Description Interval E-value
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 480-916 4.34e-106

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 333.20  E-value: 4.34e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 480 GRNMRRDPLHEELLGQGCVFQERHGWERPGWFHpqgpapvleydyygaygsrphedyayrrlladeytfdfpphhDTIKK 559
Cdd:COG0404     1 FRPLRRTPLHDRHVALGAKFVDFGGWEMPVQYP------------------------------------------GGVIA 38

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 560 ECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADVSR-PPGSTVYTCMLNHRGGTESDLTVSRLAPshqasplapa 638
Cdd:COG0404    39 EHLAVREAVGLFDVSHMGKIEVTGPDAAAFLDRLVTNDVSKlKPGRARYTLMLNEDGGIIDDLTVYRLGE---------- 108

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 639 fegDGYYLAVGGAVAQHNWSHITTVLQDQkFQCQLIDSSEDLGMVSIQGPASRAILQEVLDADLSneAFPFSTHKLLRAA 718
Cdd:COG0404   109 ---DRFLLVVNAANAAKDLAWLEEHLPPD-FDVTITDVTDDWALLAVQGPKAREVLAKLTDADLS--ALPFMSFREGTVA 182

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 719 GHLVRAMRLSFVGELGWELHIPKVSCVPVYRAVMAAGAKHGLVNAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFT 798
Cdd:COG0404   183 GVPVRVSRTGYTGEDGFEIYVPAEDAEALWDALLEAGEEFGVKPCGLGARDTLRLEAGYPLYGHELDETTTPLEAGLGWA 262

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 799 CKLKSPvPFLGREALEQQRAAGLRRRLVCFTVEDKVPMFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYIHDpsggpv 878
Cdd:COG0404   263 VKLDKG-DFIGKEALLRQKEEGPRRKLVGLELDGRGVPRAGAPVLADGEVVGEVTSGTFSPTLGKSIALAYVPA------ 335

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1622869999 879 slDFVKSGD-YALERMGVTYGARAHLKSPFDPDNKRVKG 916
Cdd:COG0404   336 --GLARPGTeLEVEIRGKRVPAEVVKPPFYDPEGERLRG 372
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
66-444 5.86e-85

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 276.79  E-value: 5.86e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999  66 TANVVVIGGGSLGCQTLYHLAKLGMSgAVLLERERLTSGTTWHTAGLLWQLRPSDVEVELLAHTRRVVS--RELEEETGL 143
Cdd:COG0665     2 TADVVVIGGGIAGLSTAYHLARRGLD-VTVLERGRPGSGASGRNAGQLRPGLAALADRALVRLAREALDlwRELAAELGI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 144 HTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCSTLARA 223
Cdd:COG0665    81 DCDFRRTGVLYLARTEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLYDPDDGHVDPAKLVRALARA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 224 ASARGAQVIENCPVTGIRVwTDDfgvrRVAGVETPHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTERIEG 303
Cdd:COG0665   161 ARAAGVRIREGTPVTGLER-EGG----RVTGVRTERGTVRADAVVLAAGAWSARLLPMLGLRLPLRPVRGYVLVTEPLPD 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 304 IQNMPNVRDHDasVYLRLQGD-ALSVGGyeanpifweevSDKFAFGLFDLDWEVFTQHIEGAINRVPVLEKTGIKSTVCG 382
Cdd:COG0665   236 LPLRPVLDDTG--VYLRPTADgRLLVGG-----------TAEPAGFDRAPTPERLEALLRRLRRLFPALADAEIVRAWAG 302

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622869999 383 PESFTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRR 444
Cdd:COG0665   303 LRPMTPDGLPIIGRLPGAPGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPDR 364
GCV_T pfam01571
Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, ...
 489-798 7.70e-69

Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 460255  Cd Length: 254  Bit Score: 229.40  E-value: 7.70e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 489 HEELLGQGCVFQERHGWERPGWFHPQGpapvleydyygaygsrphedyayrrlladeytfdfpphhdtIKKECLACRGAA 568
Cdd:pfam01571   1 YDRHVALGAKFVEFAGWEMPVQYGSNG-----------------------------------------ILAEHRAVREAA 39

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 569 AVFDMSYFGKFYLVGLDARKAADWLFSADVSR-PPGSTVYTCMLNHRGGTESDLTVSRLAPSHqasplapafegdgYYLA 647
Cdd:pfam01571  40 GLFDVSHMGKIEVSGPDAAAFLQRLTTNDVSKlKPGRATYTLMLNERGGVIDDLTVYRLGDDH-------------FLLV 106

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 648 VGGAVAQHNWSHITTVLQdqKFQCQLIDSSEDLGMVSIQGPASRAILQEVLDADLsNEAFPFSTHKLLRAAGHLVRAMRL 727
Cdd:pfam01571 107 VNAANREKDLAWLRKHAE--KLDVVVVDVTDDYALLALQGPKAREVLEKLTDGDL-LEALPFFSFREIEIGGVPVRVSRT 183

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622869999 728 SFVGELGWELHIPKVSCVPVYRAVMAAGAKHGLVNAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFT 798
Cdd:pfam01571 184 GYTGEDGFEIYVPAEDAVELWEALLEAGAELGLRPAGLGARDSLRLEAGLPLYGHDLDEETTPLEAGLGWA 254
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 69-427 8.82e-60

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 207.64  E-value: 8.82e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999  69 VVVIGGGSLGCQTLYHLAKLGMSgAVLLERE-RLTSGTTWHTAGLLWQLR---PSDVEVELLAHTRRVVsRELEEETGLH 144
Cdd:pfam01266   2 VVVIGGGIVGLSTAYELARRGLS-VTLLERGdDPGSGASGRNAGLIHPGLrylEPSELARLALEALDLW-EELEEELGID 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 145 TGWIQNGGLFIASNrQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPLmnVDDLYGTLYVPHDGTMDPAGTCSTLARAA 224
Cdd:pfam01266  80 CGFRRCGVLVLARD-EEEEALEKLLAALRRLGVPAELLDAEELRELEPL--LPGLRGGLFYPDGGHVDPARLLRALARAA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 225 SARGAQVIENCPVTGIRVWTDDFGVRRVAGVEtphgsiqtpCVVNCAGVWASAVgRMAGVKVPLVAMHHAYVVTERIEGI 304
Cdd:pfam01266 157 EALGVRIIEGTEVTGIEEEGGVWGVVTTGEAD---------AVVNAAGAWADLL-ALPGLRLPVRPVRGQVLVLEPLPEA 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 305 QN---MPNVRDHDASVYLRLQGD-ALSVGGYEanpifweevsDKFAFGLFDLDWEVFTQHIEGAINRVPVLEKtgIKSTV 380
Cdd:pfam01266 227 LLilpVPITVDPGRGVYLRPRADgRLLLGGTD----------EEDGFDDPTPDPEEIEELLEAARRLFPALAD--IERAW 294

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1622869999 381 CGPESfTPDHKPLMGEaPELRGFFLGCGFNSAGMMLGGGCGQELAHW 427
Cdd:pfam01266 295 AGLRP-LPDGLPIIGR-PGSPGLYLATGHGGHGLTLAPGIGKLLAEL 339
gcvT PRK00389
glycine cleavage system aminomethyltransferase GcvT;
549-881 1.19e-49

glycine cleavage system aminomethyltransferase GcvT;


Pssm-ID: 234742 [Multi-domain]  Cd Length: 359  Bit Score: 179.54  E-value: 1.19e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 549 DFPPHHDTIKKECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADVSR-PPGSTVYTCMLNHRGGTESDLTVSRLA 627
Cdd:PRK00389   25 EMPVQYGSIIEEHHAVRTDAGLFDVSHMGEVDVTGPDALAFLQYLLANDVSKlKPGKAQYTCMLNEDGGVIDDLIVYKLS 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 628 PshqasplapafegDGYYLAVGGAVAQHNWSHITTVLQDqkFQCQLIDSSEDLGMVSIQGPASRAILQEVLDADLSnEAF 707
Cdd:PRK00389  105 E-------------DEYLLVVNAANREKDLAWIKSHAAG--FGVEVTDRSDDLAMIAVQGPKAREKLQKLTDADLS-ELK 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 708 PFSTHKLLRAAGHLVRAMRLSFVGELGWELHIPKVSCVPVYRAVMAAGAKH-GLvnaGYRaiDSLSIEKGYR-HWHaDLR 785
Cdd:PRK00389  169 PFFGAQGAEVGGGDVLVARTGYTGEDGFEIYLPAEDAEALWDALLEAGVKPcGL---GAR--DTLRLEAGMPlYGQ-DMD 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 786 PDDSPLEAGLAFTCKLKSPVPFLGREALEQQRAAGLRRRLVCFTVEDK-VPMFGLEaIWRNGQVVGHVRRADFGFAIDKT 864
Cdd:PRK00389  243 ETITPLEAGLGWTVKLEEKRDFIGREALEAQKEAGVERKLVGLELEERgIPRHGYP-VLADGEEIGEVTSGTFSPTLGKS 321

                         330
                  ....*....|....*..
gi 1622869999 865 IAYGYIHDPSGGPVSLD 881
Cdd:PRK00389  322 IALAYVPAGVGDEVEVE 338
FAO_M pfam16350
FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent ...
 430-485 2.99e-21

FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent oxidoreductases: Sarcosine dehydrogenase, Dimethylglycine dehydrogenase and Dimethylglycine dehydrogenase. It is situated between the DAO domain (pfam01266) and the GCV_T domain (pfam01571).


Pssm-ID: 465100  Cd Length: 56  Bit Score: 87.51  E-value: 2.99e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622869999 430 HGRPEKDMHGYDIRRFHHsLTDHPRWIRERSHESYAKNYSVVFPHDEPLAGRNMRR 485
Cdd:pfam16350   1 DGEPPIDLWECDIRRFGP-HQNNREYLRERVAENYGEVYDIHHPNEEREAGRPLRT 55
glpA PRK11101
anaerobic glycerol-3-phosphate dehydrogenase subunit A;
64-286 5.01e-16

anaerobic glycerol-3-phosphate dehydrogenase subunit A;


Pssm-ID: 236847 [Multi-domain]  Cd Length: 546  Bit Score: 82.37  E-value: 5.01e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999  64 PSTANVVVIGGGSLGCQTLYHLAKLGMSgAVLLERERLTSGTTWHTAGLL-----WQLRPSDVEVELLAHTR--RVVSRE 136
Cdd:PRK11101    4 SQETDVIIIGGGATGAGIARDCALRGLR-CILVERHDIATGATGRNHGLLhsgarYAVTDAESARECISENQilKRIARH 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 137 LEEETGlhtgwiqngGLFIASNRQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPLMNvDDLYGTLYVPhDGTMDPAGT 216
Cdd:PRK11101   83 CVEPTD---------GLFITLPEDDLAFQATFIRACEEAGIEAEAIDPQQALILEPAVN-PALIGAVKVP-DGTVDPFRL 151

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622869999 217 CSTLARAASARGAQVIENCPVTG-IRVWTDDFGVRRVAGVETPHGSIQTPCVVNCAGVWASAVGRMAGVKV 286
Cdd:PRK11101  152 TAANMLDAKEHGAQILTYHEVTGlIREGDTVCGVRVRDHLTGETQEIHAPVVVNAAGIWGQHIAEYADLRI 222
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 68-445 3.61e-13

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 72.17  E-value: 3.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999  68 NVVVIGGGSLGCQTLYHLAKLGMSgAVLLERERL--TSGTTWHTAGLLWQLRPSDVEVELLAHTRRVVSrELEEETG--L 143
Cdd:TIGR01377   2 DVIVVGAGIMGCFAAYHLAKHGKK-TLLLEQFDLphSRGSSHGQSRIIRKAYPEDFYTPMMLECYQLWA-QLEKEAGtkL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 144 HTgwiQNGGLFIASNRQRldEYKRLMSLGKAYGVESHVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCSTLARA 223
Cdd:TIGR01377  80 HR---QTGLLLLGPKENQ--FLKTIQATLSRHGLEHELLSSKQLKQRFPNIRVPRNEVGLLDPNGGVLYAEKALRALQEL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 224 ASARGAQVIENCPVTGIRVWTDdfgvrrVAGVETPHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTERIEG 303
Cdd:TIGR01377 155 AEAHGATVRDGTKVVEIEPTEL------LVTVKTTKGSYQANKLVVTAGAWTSKLLSPLGIEIPLQPLRINVCYWREKEP 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 304 -----IQNMPNVRDHDASVYL----RLQGDALSV----GGYEANP--IFWEevsdkfaFGLFDLDWEVFTQHIEgaiNRV 368
Cdd:TIGR01377 229 gsygvSQAFPCFLVLGLNPHIyglpSFEYPGLMKvyyhHGQQIDPdeRDCP-------FGADIEDVQILRKFVR---DHL 298

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622869999 369 PVLEKTGIKSTVCgPESFTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRF 445
Cdd:TIGR01377 299 PGLNGEPKKGEVC-MYTNTPDEHFVIDLHPKYDNVVIGAGFSGHGFKLAPVVGKILAELAMKLKPSYDLAIFSLNRF 374
 
Name Accession Description Interval E-value
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 480-916 4.34e-106

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 333.20  E-value: 4.34e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 480 GRNMRRDPLHEELLGQGCVFQERHGWERPGWFHpqgpapvleydyygaygsrphedyayrrlladeytfdfpphhDTIKK 559
Cdd:COG0404     1 FRPLRRTPLHDRHVALGAKFVDFGGWEMPVQYP------------------------------------------GGVIA 38

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 560 ECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADVSR-PPGSTVYTCMLNHRGGTESDLTVSRLAPshqasplapa 638
Cdd:COG0404    39 EHLAVREAVGLFDVSHMGKIEVTGPDAAAFLDRLVTNDVSKlKPGRARYTLMLNEDGGIIDDLTVYRLGE---------- 108

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 639 fegDGYYLAVGGAVAQHNWSHITTVLQDQkFQCQLIDSSEDLGMVSIQGPASRAILQEVLDADLSneAFPFSTHKLLRAA 718
Cdd:COG0404   109 ---DRFLLVVNAANAAKDLAWLEEHLPPD-FDVTITDVTDDWALLAVQGPKAREVLAKLTDADLS--ALPFMSFREGTVA 182

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 719 GHLVRAMRLSFVGELGWELHIPKVSCVPVYRAVMAAGAKHGLVNAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFT 798
Cdd:COG0404   183 GVPVRVSRTGYTGEDGFEIYVPAEDAEALWDALLEAGEEFGVKPCGLGARDTLRLEAGYPLYGHELDETTTPLEAGLGWA 262

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 799 CKLKSPvPFLGREALEQQRAAGLRRRLVCFTVEDKVPMFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYIHDpsggpv 878
Cdd:COG0404   263 VKLDKG-DFIGKEALLRQKEEGPRRKLVGLELDGRGVPRAGAPVLADGEVVGEVTSGTFSPTLGKSIALAYVPA------ 335

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1622869999 879 slDFVKSGD-YALERMGVTYGARAHLKSPFDPDNKRVKG 916
Cdd:COG0404   336 --GLARPGTeLEVEIRGKRVPAEVVKPPFYDPEGERLRG 372
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
66-444 5.86e-85

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 276.79  E-value: 5.86e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999  66 TANVVVIGGGSLGCQTLYHLAKLGMSgAVLLERERLTSGTTWHTAGLLWQLRPSDVEVELLAHTRRVVS--RELEEETGL 143
Cdd:COG0665     2 TADVVVIGGGIAGLSTAYHLARRGLD-VTVLERGRPGSGASGRNAGQLRPGLAALADRALVRLAREALDlwRELAAELGI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 144 HTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCSTLARA 223
Cdd:COG0665    81 DCDFRRTGVLYLARTEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLYDPDDGHVDPAKLVRALARA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 224 ASARGAQVIENCPVTGIRVwTDDfgvrRVAGVETPHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTERIEG 303
Cdd:COG0665   161 ARAAGVRIREGTPVTGLER-EGG----RVTGVRTERGTVRADAVVLAAGAWSARLLPMLGLRLPLRPVRGYVLVTEPLPD 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 304 IQNMPNVRDHDasVYLRLQGD-ALSVGGyeanpifweevSDKFAFGLFDLDWEVFTQHIEGAINRVPVLEKTGIKSTVCG 382
Cdd:COG0665   236 LPLRPVLDDTG--VYLRPTADgRLLVGG-----------TAEPAGFDRAPTPERLEALLRRLRRLFPALADAEIVRAWAG 302

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622869999 383 PESFTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRR 444
Cdd:COG0665   303 LRPMTPDGLPIIGRLPGAPGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPDR 364
GCV_T pfam01571
Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, ...
 489-798 7.70e-69

Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 460255  Cd Length: 254  Bit Score: 229.40  E-value: 7.70e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 489 HEELLGQGCVFQERHGWERPGWFHPQGpapvleydyygaygsrphedyayrrlladeytfdfpphhdtIKKECLACRGAA 568
Cdd:pfam01571   1 YDRHVALGAKFVEFAGWEMPVQYGSNG-----------------------------------------ILAEHRAVREAA 39

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 569 AVFDMSYFGKFYLVGLDARKAADWLFSADVSR-PPGSTVYTCMLNHRGGTESDLTVSRLAPSHqasplapafegdgYYLA 647
Cdd:pfam01571  40 GLFDVSHMGKIEVSGPDAAAFLQRLTTNDVSKlKPGRATYTLMLNERGGVIDDLTVYRLGDDH-------------FLLV 106

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 648 VGGAVAQHNWSHITTVLQdqKFQCQLIDSSEDLGMVSIQGPASRAILQEVLDADLsNEAFPFSTHKLLRAAGHLVRAMRL 727
Cdd:pfam01571 107 VNAANREKDLAWLRKHAE--KLDVVVVDVTDDYALLALQGPKAREVLEKLTDGDL-LEALPFFSFREIEIGGVPVRVSRT 183

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622869999 728 SFVGELGWELHIPKVSCVPVYRAVMAAGAKHGLVNAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFT 798
Cdd:pfam01571 184 GYTGEDGFEIYVPAEDAVELWEALLEAGAELGLRPAGLGARDSLRLEAGLPLYGHDLDEETTPLEAGLGWA 254
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 69-427 8.82e-60

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 207.64  E-value: 8.82e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999  69 VVVIGGGSLGCQTLYHLAKLGMSgAVLLERE-RLTSGTTWHTAGLLWQLR---PSDVEVELLAHTRRVVsRELEEETGLH 144
Cdd:pfam01266   2 VVVIGGGIVGLSTAYELARRGLS-VTLLERGdDPGSGASGRNAGLIHPGLrylEPSELARLALEALDLW-EELEEELGID 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 145 TGWIQNGGLFIASNrQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPLmnVDDLYGTLYVPHDGTMDPAGTCSTLARAA 224
Cdd:pfam01266  80 CGFRRCGVLVLARD-EEEEALEKLLAALRRLGVPAELLDAEELRELEPL--LPGLRGGLFYPDGGHVDPARLLRALARAA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 225 SARGAQVIENCPVTGIRVWTDDFGVRRVAGVEtphgsiqtpCVVNCAGVWASAVgRMAGVKVPLVAMHHAYVVTERIEGI 304
Cdd:pfam01266 157 EALGVRIIEGTEVTGIEEEGGVWGVVTTGEAD---------AVVNAAGAWADLL-ALPGLRLPVRPVRGQVLVLEPLPEA 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 305 QN---MPNVRDHDASVYLRLQGD-ALSVGGYEanpifweevsDKFAFGLFDLDWEVFTQHIEGAINRVPVLEKtgIKSTV 380
Cdd:pfam01266 227 LLilpVPITVDPGRGVYLRPRADgRLLLGGTD----------EEDGFDDPTPDPEEIEELLEAARRLFPALAD--IERAW 294

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1622869999 381 CGPESfTPDHKPLMGEaPELRGFFLGCGFNSAGMMLGGGCGQELAHW 427
Cdd:pfam01266 295 AGLRP-LPDGLPIIGR-PGSPGLYLATGHGGHGLTLAPGIGKLLAEL 339
gcvT PRK00389
glycine cleavage system aminomethyltransferase GcvT;
549-881 1.19e-49

glycine cleavage system aminomethyltransferase GcvT;


Pssm-ID: 234742 [Multi-domain]  Cd Length: 359  Bit Score: 179.54  E-value: 1.19e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 549 DFPPHHDTIKKECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADVSR-PPGSTVYTCMLNHRGGTESDLTVSRLA 627
Cdd:PRK00389   25 EMPVQYGSIIEEHHAVRTDAGLFDVSHMGEVDVTGPDALAFLQYLLANDVSKlKPGKAQYTCMLNEDGGVIDDLIVYKLS 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 628 PshqasplapafegDGYYLAVGGAVAQHNWSHITTVLQDqkFQCQLIDSSEDLGMVSIQGPASRAILQEVLDADLSnEAF 707
Cdd:PRK00389  105 E-------------DEYLLVVNAANREKDLAWIKSHAAG--FGVEVTDRSDDLAMIAVQGPKAREKLQKLTDADLS-ELK 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 708 PFSTHKLLRAAGHLVRAMRLSFVGELGWELHIPKVSCVPVYRAVMAAGAKH-GLvnaGYRaiDSLSIEKGYR-HWHaDLR 785
Cdd:PRK00389  169 PFFGAQGAEVGGGDVLVARTGYTGEDGFEIYLPAEDAEALWDALLEAGVKPcGL---GAR--DTLRLEAGMPlYGQ-DMD 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 786 PDDSPLEAGLAFTCKLKSPVPFLGREALEQQRAAGLRRRLVCFTVEDK-VPMFGLEaIWRNGQVVGHVRRADFGFAIDKT 864
Cdd:PRK00389  243 ETITPLEAGLGWTVKLEEKRDFIGREALEAQKEAGVERKLVGLELEERgIPRHGYP-VLADGEEIGEVTSGTFSPTLGKS 321

                         330
                  ....*....|....*..
gi 1622869999 865 IAYGYIHDPSGGPVSLD 881
Cdd:PRK00389  322 IALAYVPAGVGDEVEVE 338
PLN02319 PLN02319
aminomethyltransferase
 555-870 6.57e-26

aminomethyltransferase


Pssm-ID: 177953 [Multi-domain]  Cd Length: 404  Bit Score: 111.35  E-value: 6.57e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 555 DTIKKECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADV-SRPPGSTVYTCMLNHRGGTESDLTVSRLapshqas 633
Cdd:PLN02319   62 DSIMDSTLNCRQNGSLFDVSHMCGLSLKGKDAIPFLETLVVADIaGLKDGTGTLSVFTNEKGGIIDDTVITKV------- 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 634 plapafEGDGYYLAVGGAVAQHNWSHITTVLqdQKFQCQLIDSSE----DLGMVSIQGPASRAILQEVLDADLSneAFPF 709
Cdd:PLN02319  135 ------TDDHIYLVVNAGCRDKDLAHIEEHM--KAFKAKGGDVSWhvhdERSLLALQGPLAAPVLQHLTKEDLS--KMYF 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 710 STHKLLRAAGHLVRAMRLSFVGELGWELHIPKVSCVPVYRAVMAagAKHGLVN-AGYRAIDSLSIEKGYRHWHADLRPDD 788
Cdd:PLN02319  205 GDFRITDINGADCFLTRTGYTGEDGFEISVPSEHAVDLAKALLE--KSEGKVRlTGLGARDSLRLEAGLCLYGNDLEEHI 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 789 SPLEAGLAFTC--KLKSPVPFLGREALEQQRAAGLRRRLVCFTVEDKVPMFGLEAIWRNGQVVGHVRRADFGFAIDKTIA 866
Cdd:PLN02319  283 TPVEAGLAWTIgkRRRAEGGFLGADVILKQLKEGVSRRRVGFISSGAPARSHSEILDESGEKIGEVTSGGFSPCLKKNIA 362


                  ....
gi 1622869999 867 YGYI 870
Cdd:PLN02319  363 MGYV 366
FAO_M pfam16350
FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent ...
 430-485 2.99e-21

FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent oxidoreductases: Sarcosine dehydrogenase, Dimethylglycine dehydrogenase and Dimethylglycine dehydrogenase. It is situated between the DAO domain (pfam01266) and the GCV_T domain (pfam01571).


Pssm-ID: 465100  Cd Length: 56  Bit Score: 87.51  E-value: 2.99e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622869999 430 HGRPEKDMHGYDIRRFHHsLTDHPRWIRERSHESYAKNYSVVFPHDEPLAGRNMRR 485
Cdd:pfam16350   1 DGEPPIDLWECDIRRFGP-HQNNREYLRERVAENYGEVYDIHHPNEEREAGRPLRT 55
LhgO COG0579
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
69-284 2.34e-19

L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];


Pssm-ID: 440344 [Multi-domain]  Cd Length: 418  Bit Score: 91.75  E-value: 2.34e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999  69 VVVIGGGSLGCQTLYHLAKLgmSGA--VLLERE-RLTSGTTWHTAGLLwqlrpsdvevellaHT-----------RRVVS 134
Cdd:COG0579     7 VVIIGAGIVGLALARELSRY--EDLkvLVLEKEdDVAQESSGNNSGVI--------------HAglyytpgslkaRLCVE 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 135 -----RELEEETGLhtGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVES-HVLSPAETKTLYPLMNVDDLYGtLYVPHD 208
Cdd:COG0579    71 gnelfYELCRELGI--PFKRCGKLVVATGEEEVAFLEKLYERGKANGVPGlEILDREELRELEPLLSDEGVAA-LYSPST 147

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622869999 209 GTMDPAGTCSTLARAASARGAQVIENCPVTGIRVWTDDFGVrrvagvETPHGSIQTPCVVNCAGVWASAVGRMAGV 284
Cdd:COG0579   148 GIVDPGALTRALAENAEANGVELLLNTEVTGIEREGDGWEV------TTNGGTIRARFVINAAGLYADRLAQMAGI 217
glpA PRK11101
anaerobic glycerol-3-phosphate dehydrogenase subunit A;
64-286 5.01e-16

anaerobic glycerol-3-phosphate dehydrogenase subunit A;


Pssm-ID: 236847 [Multi-domain]  Cd Length: 546  Bit Score: 82.37  E-value: 5.01e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999  64 PSTANVVVIGGGSLGCQTLYHLAKLGMSgAVLLERERLTSGTTWHTAGLL-----WQLRPSDVEVELLAHTR--RVVSRE 136
Cdd:PRK11101    4 SQETDVIIIGGGATGAGIARDCALRGLR-CILVERHDIATGATGRNHGLLhsgarYAVTDAESARECISENQilKRIARH 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 137 LEEETGlhtgwiqngGLFIASNRQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPLMNvDDLYGTLYVPhDGTMDPAGT 216
Cdd:PRK11101   83 CVEPTD---------GLFITLPEDDLAFQATFIRACEEAGIEAEAIDPQQALILEPAVN-PALIGAVKVP-DGTVDPFRL 151

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622869999 217 CSTLARAASARGAQVIENCPVTG-IRVWTDDFGVRRVAGVETPHGSIQTPCVVNCAGVWASAVGRMAGVKV 286
Cdd:PRK11101  152 TAANMLDAKEHGAQILTYHEVTGlIREGDTVCGVRVRDHLTGETQEIHAPVVVNAAGIWGQHIAEYADLRI 222
GCV_T_C pfam08669
Glycine cleavage T-protein C-terminal barrel domain; This is a family of glycine cleavage ...
 823-908 1.90e-15

Glycine cleavage T-protein C-terminal barrel domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 462554 [Multi-domain]  Cd Length: 80  Bit Score: 72.12  E-value: 1.90e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 823 RRLVCFTVED-KVPMFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYIHDpsggpvslDFVKSG-DYALERMGVTYGAR 900
Cdd:pfam08669   1 RRLVGLELDDgDPLLRGGEPVLRDGEVVGYVTSGAYSPTLGKSIALAYVDA--------ELAKPGtEVEVEIRGKRVPAT 72


                  ....*...
gi 1622869999 901 AHLKSPFD 908
Cdd:pfam08669  73 VVKLPFYD 80
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 68-445 3.61e-13

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 72.17  E-value: 3.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999  68 NVVVIGGGSLGCQTLYHLAKLGMSgAVLLERERL--TSGTTWHTAGLLWQLRPSDVEVELLAHTRRVVSrELEEETG--L 143
Cdd:TIGR01377   2 DVIVVGAGIMGCFAAYHLAKHGKK-TLLLEQFDLphSRGSSHGQSRIIRKAYPEDFYTPMMLECYQLWA-QLEKEAGtkL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 144 HTgwiQNGGLFIASNRQRldEYKRLMSLGKAYGVESHVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCSTLARA 223
Cdd:TIGR01377  80 HR---QTGLLLLGPKENQ--FLKTIQATLSRHGLEHELLSSKQLKQRFPNIRVPRNEVGLLDPNGGVLYAEKALRALQEL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 224 ASARGAQVIENCPVTGIRVWTDdfgvrrVAGVETPHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTERIEG 303
Cdd:TIGR01377 155 AEAHGATVRDGTKVVEIEPTEL------LVTVKTTKGSYQANKLVVTAGAWTSKLLSPLGIEIPLQPLRINVCYWREKEP 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 304 -----IQNMPNVRDHDASVYL----RLQGDALSV----GGYEANP--IFWEevsdkfaFGLFDLDWEVFTQHIEgaiNRV 368
Cdd:TIGR01377 229 gsygvSQAFPCFLVLGLNPHIyglpSFEYPGLMKvyyhHGQQIDPdeRDCP-------FGADIEDVQILRKFVR---DHL 298

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622869999 369 PVLEKTGIKSTVCgPESFTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRF 445
Cdd:TIGR01377 299 PGLNGEPKKGEVC-MYTNTPDEHFVIDLHPKYDNVVIGAGFSGHGFKLAPVVGKILAELAMKLKPSYDLAIFSLNRF 374
PRK00711 PRK00711
D-amino acid dehydrogenase;
126-288 9.15e-12

D-amino acid dehydrogenase;


Pssm-ID: 234819 [Multi-domain]  Cd Length: 416  Bit Score: 68.29  E-value: 9.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 126 LAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYP-LMNV-DDLYGTL 203
Cdd:PRK00711  111 LAEYSRDCLKALRAETGIQYEGRQGGTLQLFRTQQQLDAAAKDIAVLEEAGVPYELLDRDELAAVEPaLAGVrHKLVGGL 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 204 YVPHDGTMDPAGTCSTLARAASARGAQVIENCPVTGIRVWTDdfgvrRVAGVETPHGSIQTPCVVNCAGVWASAVGRMAG 283
Cdd:PRK00711  191 RLPNDETGDCQLFTQRLAAMAEQLGVKFRFNTPVDGLLVEGG-----RITGVQTGGGVITADAYVVALGSYSTALLKPLG 265


                  ....*
gi 1622869999 284 VKVPL 288
Cdd:PRK00711  266 VDIPV 270
PRK12409 PRK12409
D-amino acid dehydrogenase small subunit; Provisional
 68-286 2.69e-11

D-amino acid dehydrogenase small subunit; Provisional


Pssm-ID: 237093 [Multi-domain]  Cd Length: 410  Bit Score: 66.59  E-value: 2.69e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999  68 NVVVIGGGSLGCQTLYHLAKLGMSGAVLlERERL----TS-----------------------GTTWHT---AGLLWQLR 117
Cdd:PRK12409    3 HIAVIGAGITGVTTAYALAQRGYQVTVF-DRHRYaameTSfanggqlsasnaevwnhwatvlkGLKWMLrkdAPLLLNPK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 118 PS----DVEVELLAHTRR------------VVSRE----LEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGV 177
Cdd:PRK12409   82 PSwhkySWLAEFLAHIPNyrantietvrlaIAARKhlfdIAEREGIDFDLERRGILHIYHDKAGFDHAKRVNALLAEGGL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 178 ESHVLSPAETKTLYPLMNvDDLYGTLYVPHDGTMDPAGTCSTLARAASARGAQVIENCPVTGIRVWTDDFGVRRVAGVET 257
Cdd:PRK12409  162 ERRAVTPEEMRAIEPTLT-GEYYGGYYTPSDSTGDIHKFTTGLAAACARLGVQFRYGQEVTSIKTDGGGVVLTVQPSAEH 240

                         250       260
                  ....*....|....*....|....*....
gi 1622869999 258 PHGSIQTPCVVNCAGVWASAVGRMAGVKV 286
Cdd:PRK12409  241 PSRTLEFDGVVVCAGVGSRALAAMLGDRV 269
solA PRK11259
N-methyl-L-tryptophan oxidase;
69-276 6.55e-11

N-methyl-L-tryptophan oxidase;


Pssm-ID: 236887 [Multi-domain]  Cd Length: 376  Bit Score: 65.24  E-value: 6.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999  69 VVVIGGGSLGCQTLYHLAKLGMSgaVL-LER-------------ERLTsgttwhtagllwqlR------PSDVEVELLAH 128
Cdd:PRK11259    6 VIVIGLGSMGSAAGYYLARRGLR--VLgLDRfmpphqqgsshgdTRII--------------RhaygegPAYVPLVLRAQ 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 129 TrrvVSRELEEETG---LHtgwiQNGGLFIASNRQRLdeYKRLMSLGKAYGVESHVLSPAETKTLYPLMNVDDLYGTLYV 205
Cdd:PRK11259   70 E---LWRELERESGeplFV----RTGVLNLGPADSDF--LANSIRSARQHGLPHEVLDAAEIRRRFPQFRLPDGYIALFE 140

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622869999 206 PHDGTMDPAGTCSTLARAASARGAQVIENCPVTGIRvwTDDFGVRrvagVETPHGSIQTPCVVNCAGVWAS 276
Cdd:PRK11259  141 PDGGFLRPELAIKAHLRLAREAGAELLFNEPVTAIE--ADGDGVT----VTTADGTYEAKKLVVSAGAWVK 205
PRK11728 PRK11728
L-2-hydroxyglutarate oxidase;
151-286 7.30e-11

L-2-hydroxyglutarate oxidase;


Pssm-ID: 183292 [Multi-domain]  Cd Length: 393  Bit Score: 65.23  E-value: 7.30e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 151 GGLFIASNRQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPlmNVDDLyGTLYVPHDGTMDPAGTCSTLARAASARGAQ 230
Cdd:PRK11728   89 GKLLVATSELELERMEALYERARANGIEVERLDAEELREREP--NIRGL-GAIFVPSTGIVDYRAVAEAMAELIQARGGE 165

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622869999 231 VIENCPVTGIRvwTDDFGVRrvagVETPHGSIQTPCVVNCAGVWASAVGRMAGVKV 286
Cdd:PRK11728  166 IRLGAEVTALD--EHANGVV----VRTTQGEYEARTLINCAGLMSDRLAKMAGLEP 215
GlpA COG0578
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 171-287 1.75e-09

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440343 [Multi-domain]  Cd Length: 501  Bit Score: 61.30  E-value: 1.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 171 LGKAYGVESH-VLSPAETKTLYPLMNVDDL-YGTLYvpHDGTMDPAGTCSTLARAASARGAQVIENCPVTGI-----RVW 243
Cdd:COG0578    93 LAGRKGLPRHrRLSRAEALALAPLLRPDGLrGGFEY--YDAQVDDARLVLELARTAAERGAVVLNYTRVTGLlrdggRVW 170

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1622869999 244 tddfGVR---RVAGVETphgSIQTPCVVNCAGVWASAVGRMAGVKVP 287
Cdd:COG0578   171 ----GVTvrdRLTGEEF---TVRARVVVNATGPWVDELRALDGPKAP 210
dmdA PRK12486
dimethylsulfoniopropionate demethylase;
551-870 1.53e-07

dimethylsulfoniopropionate demethylase;


Pssm-ID: 237113 [Multi-domain]  Cd Length: 368  Bit Score: 54.37  E-value: 1.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 551 PPHHDTIKKECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADVSR-PPGSTVYTCMLNHRGGTESDLTVSRLAPS 629
Cdd:PRK12486   37 PTVFESVEDDYAHLKEHVQVWDVAVERQVEIRGPDAARLVQMLTPRDLRGmKPGQCYYVPIVDETGGMLNDPVALKLAED 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 630 HQASPLApafEGDGYYLAVGGAVAqhnwsHITTVLQDQKfqcqlidsseDLGMVSIQGPASRAILQEVLDADLSN----- 704
Cdd:PRK12486  117 RWWISIA---DSDLLLWVKGLANG-----RKLDVLVVEP----------DVSPLAVQGPKADALMARVFGEAIRDlrffr 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 705 -EAFPFSTHKLLRAaghlvramRLSFVGELGWELHIPKV-SCVPVYRAVMAAGAKHGlVNAGY-RAIDSlsIEKGYRHWH 781
Cdd:PRK12486  179 fGYFDFEGTDLVIA--------RSGYSKQGGFEIYVEGSdLGMPLWDALFEAGKDLN-VRAGCpNLIER--IEGGLLSYG 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 782 ADLRPDDSPLEAGLAFTCKLKSPVPFLGREALEQQRAAGLRRRLVCFTVE-DKVPMFGleAIWR---NGQVVGHVRRADF 857
Cdd:PRK12486  248 NDMTRDNTPHECGLGRFCNTQTDIGCIGKDALLRVAKEGPQKQIRGIKIGgERIPPCD--RAWPllaGDNRVGQVTSAAY 325

                         330
                  ....*....|...
gi 1622869999 858 GFAIDKTIAYGYI 870
Cdd:PRK12486  326 SPDFQTNVAIGMV 338
PLN02464 PLN02464
glycerol-3-phosphate dehydrogenase
 1-287 8.89e-03

glycerol-3-phosphate dehydrogenase


Pssm-ID: 215257 [Multi-domain]  Cd Length: 627  Bit Score: 39.76  E-value: 8.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999   1 MASLSRALRVAAAC-----------PRQSPTRGLGPCNLSSASGPTAEKSVPYQRTlkegQGTSVVAQGPSRPLpstaNV 69
Cdd:PLN02464    3 LARLRRLAAGAAATaaggavylspqPASSDKGGGPALDSLRDRIADPNASVPSRSA----QESALIGATAAEPL----DV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999  70 VVIGGGSLGCQTLYHLAKLGMSGAvLLERERLTSGTTWHTAGLLWQ-LRPSDVEV-ELLAHTRRVVSRELEEETGLhtgw 147
Cdd:PLN02464   75 LVVGGGATGAGVALDAATRGLRVG-LVEREDFSSGTSSRSTKLIHGgVRYLEKAVfQLDYGQLKLVFHALEERKQL---- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 148 IQNG-----GLFIASNRQRLDEYKRLMSLGKAY----GVESHVLS----PAETKTLYPLMNVDDLYGTL---YVPHDGTM 211
Cdd:PLN02464  150 IENAphlchALPIMTPCYDWFEVPYYWAGLKAYdlvaGPRLLHLSryysAKESLELFPTLAKKGKDGSLkgtVVYYDGQM 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622869999 212 DPAGTCSTLARAASARGAQVIENCPVTGIrvwTDDFGVRRVAGV---ETPHGS---IQTPCVVNCAGVWASAVGRMAGVK 285
Cdd:PLN02464  230 NDSRLNVALACTAALAGAAVLNYAEVVSL---IKDESTGRIVGArvrDNLTGKefdVYAKVVVNAAGPFCDEVRKMADGK 306


                  ..
gi 1622869999 286 VP 287
Cdd:PLN02464  307 AK 308
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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