NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2241020369|ref|XP_002526388|]
View 

TLC domain-containing protein 4-B isoform X1 [Ricinus communis]

Protein Classification

TLC domain-containing protein( domain architecture ID 10653905)

TLC (TRAM, LAG1 and CLN8) domain-containing protein may possess one of multiple functions such as lipid trafficking, metabolism, or sensing

PubMed:  12151215

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
TLC smart00724
TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane ...
58-260 8.64e-31

TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. The family may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additional homeobox domains.


:

Pssm-ID: 214789  Cd Length: 205  Bit Score: 113.54  E-value: 8.64e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241020369   58 KIEWNNRGFSTFHAIVVASASFYLLmlSGLFDEDSHDelIINRSSDISNSVLGVSIGYFLADLAMILWYFPALG--GLEY 135
Cdd:smart00724   3 FNESSNRLVSYLHSVIAGLYALYSE--PWLSDPKSLY--PIQGMSPLAKFYYLFSLGYFIHDLVALLLFQDLKRkdFKEM 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241020369  136 VLHHGLSVYSIILALLSGQAQIYILMILFSESTTPFVNLRWYLDVAGQKSSKLYVSNGVLLFLGWLVARIILFICFFTHM 215
Cdd:smart00724  79 LVHHIATLLLISLSYVLNFTRLGLLLLLLHELSDPFLHLRKLLNYAGRKKSLLYDVNFVLFAVVFFVFRLILFPFLILTV 158
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 2241020369  216 FIHFDQVKKVF--PLGFYSLLSVPPVLGVMNVVWFWKIARGLIKTLS 260
Cdd:smart00724 159 TVHYAQAESGLfpPLLYLLFLLLLLCLQLLNIYWFFLILRMARKLLS 205
 
Name Accession Description Interval E-value
TLC smart00724
TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane ...
58-260 8.64e-31

TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. The family may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additional homeobox domains.


Pssm-ID: 214789  Cd Length: 205  Bit Score: 113.54  E-value: 8.64e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241020369   58 KIEWNNRGFSTFHAIVVASASFYLLmlSGLFDEDSHDelIINRSSDISNSVLGVSIGYFLADLAMILWYFPALG--GLEY 135
Cdd:smart00724   3 FNESSNRLVSYLHSVIAGLYALYSE--PWLSDPKSLY--PIQGMSPLAKFYYLFSLGYFIHDLVALLLFQDLKRkdFKEM 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241020369  136 VLHHGLSVYSIILALLSGQAQIYILMILFSESTTPFVNLRWYLDVAGQKSSKLYVSNGVLLFLGWLVARIILFICFFTHM 215
Cdd:smart00724  79 LVHHIATLLLISLSYVLNFTRLGLLLLLLHELSDPFLHLRKLLNYAGRKKSLLYDVNFVLFAVVFFVFRLILFPFLILTV 158
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 2241020369  216 FIHFDQVKKVF--PLGFYSLLSVPPVLGVMNVVWFWKIARGLIKTLS 260
Cdd:smart00724 159 TVHYAQAESGLfpPLLYLLFLLLLLCLQLLNIYWFFLILRMARKLLS 205
TRAM_LAG1_CLN8 pfam03798
TLC domain;
60-253 1.25e-23

TLC domain;


Pssm-ID: 461055  Cd Length: 200  Bit Score: 94.65  E-value: 1.25e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241020369  60 EWNNRGFSTFHAIVVASASFYLLMLSGLFDEDS-----HDELIINRSSDISNSVLGVSIGYFLADLAMILWYFPALGG-L 133
Cdd:pfam03798   1 KFSESGVSLVYYLVSTILGLYVLSSEPWFWNPTelwydYPNRVLGYTSWLVKFYYLIQLGYFIWDLLVLLFYEKRRKDfW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241020369 134 EYVLHHGLSVYSIILALLSGQAQIYILMILFSESTTPFVNLRWYLDVAGQKSSKLYVSngVLLFLGWLVARIILFICFFT 213
Cdd:pfam03798  81 EMLLHHVITLVLIVLSYFRNFTRVGLLVLLLHELSDPFLNLAKILNYLGKGTSCDVLF--VLFLVSFFVTRLVLGPFWIL 158
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2241020369 214 HMFIHFDQ--VKKVFPLGFYSLLSVPPVLGVMNVVWFWKIAR 253
Cdd:pfam03798 159 LSILDYAGldVPTGPFLLYYIFLILLLVLQLLNIYWFYLIIR 200
 
Name Accession Description Interval E-value
TLC smart00724
TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane ...
58-260 8.64e-31

TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. The family may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additional homeobox domains.


Pssm-ID: 214789  Cd Length: 205  Bit Score: 113.54  E-value: 8.64e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241020369   58 KIEWNNRGFSTFHAIVVASASFYLLmlSGLFDEDSHDelIINRSSDISNSVLGVSIGYFLADLAMILWYFPALG--GLEY 135
Cdd:smart00724   3 FNESSNRLVSYLHSVIAGLYALYSE--PWLSDPKSLY--PIQGMSPLAKFYYLFSLGYFIHDLVALLLFQDLKRkdFKEM 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241020369  136 VLHHGLSVYSIILALLSGQAQIYILMILFSESTTPFVNLRWYLDVAGQKSSKLYVSNGVLLFLGWLVARIILFICFFTHM 215
Cdd:smart00724  79 LVHHIATLLLISLSYVLNFTRLGLLLLLLHELSDPFLHLRKLLNYAGRKKSLLYDVNFVLFAVVFFVFRLILFPFLILTV 158
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 2241020369  216 FIHFDQVKKVF--PLGFYSLLSVPPVLGVMNVVWFWKIARGLIKTLS 260
Cdd:smart00724 159 TVHYAQAESGLfpPLLYLLFLLLLLCLQLLNIYWFFLILRMARKLLS 205
TRAM_LAG1_CLN8 pfam03798
TLC domain;
60-253 1.25e-23

TLC domain;


Pssm-ID: 461055  Cd Length: 200  Bit Score: 94.65  E-value: 1.25e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241020369  60 EWNNRGFSTFHAIVVASASFYLLMLSGLFDEDS-----HDELIINRSSDISNSVLGVSIGYFLADLAMILWYFPALGG-L 133
Cdd:pfam03798   1 KFSESGVSLVYYLVSTILGLYVLSSEPWFWNPTelwydYPNRVLGYTSWLVKFYYLIQLGYFIWDLLVLLFYEKRRKDfW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241020369 134 EYVLHHGLSVYSIILALLSGQAQIYILMILFSESTTPFVNLRWYLDVAGQKSSKLYVSngVLLFLGWLVARIILFICFFT 213
Cdd:pfam03798  81 EMLLHHVITLVLIVLSYFRNFTRVGLLVLLLHELSDPFLNLAKILNYLGKGTSCDVLF--VLFLVSFFVTRLVLGPFWIL 158
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2241020369 214 HMFIHFDQ--VKKVFPLGFYSLLSVPPVLGVMNVVWFWKIAR 253
Cdd:pfam03798 159 LSILDYAGldVPTGPFLLYYIFLILLLVLQLLNIYWFYLIIR 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH