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Conserved domains on  [gi|242040065|ref|XP_002467427|]
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probable inactive shikimate kinase like 2, chloroplastic [Sorghum bicolor]

Protein Classification

Hsp20/alpha crystallin family protein; Hsp20 family protein( domain architecture ID 12950391)

Hsp20/alpha crystallin family protein is a small, stress-induced protein, between 12-43 kDa, which functions as an ATP-independent chaperone that prevents aggregation and protects against cell stress, induced by heat, osmotic, or acid shock| small heat shock (Hsp20) family protein is a molecular chaperone that suppresses protein aggregation and protects against cell stress

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
p23_like cd06463
Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) ...
 84-170 5.49e-10

Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis. Both p23 and Sba1p can regulate telomerase activity. This group includes domains similar to the C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1). Sgt1 interacts with multiple protein complexes and has the features of a co-chaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has been shown to bind Hsp90 through its CS domain. Saccharomyces cerevisiae (Sc) Sgt1 is a subunit of both core kinetochore and SCF (Skp1-Cul1-F-box) ubiquitin ligase complexes. Sgt1 is required for pathogen resistance in plants. This group also includes the p23_like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR). hB-ind1 plays a role in the signaling pathway mediated by the small GTPase Rac1, NUDC is needed for nuclear movement, Melusin interacts with two splice variants of beta1 integrin, and NCB5OR plays a part in maintaining viable pancreatic beta cells.


:

Pssm-ID: 107220  Cd Length: 84  Bit Score: 55.37  E-value: 5.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242040065  84 FTDGNGEVELRLDIQKLgieSARDVFVDVDDTSLLIRAKSDGTLRTLMNVQtLFDRIKSSETIWFIDEDQLVVNLKKVEQ 163
Cdd:cd06463    1 WYQTLDEVTITIPLKDV---TKKDVKVEFTPKSLTVSVKGGGGKEYLLEGE-LFGPIDPEESKWTVEDRKIEITLKKKEP 76


                 ....*..
gi 242040065 164 ELKWPDI 170
Cdd:cd06463   77 GEWWPRL 83
PLN02199 super family cl31839
shikimate kinase
 150-290 8.94e-07

shikimate kinase


The actual alignment was detected with superfamily member PLN02199:

Pssm-ID: 177850 [Multi-domain]  Cd Length: 303  Bit Score: 50.08  E-value: 8.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242040065 150 DEDQLvvnlKKVEQELKwpdideswesltsgitQLLTGISVHIVGDSTHINEAVAKEIAEGIGYLPVCTSELLESATQ-K 228
Cdd:PLN02199  85 DEDIL----KRKAEEVK----------------PYLNGRSMYLVGMMGSGKTTVGKLMSKVLGYTFFDCDTLIEQAMNgT 144

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 242040065 229 SIDTWVASEGADSVAEAESVVLESLSSHVRTVVATLGGkqgAASRFDRWQYLHSGFTVWLSV 290
Cdd:PLN02199 145 SVAEIFVHHGENFFRGKETDALKKLSSRYQVVVSTGGG---AVIRPINWKYMHKGISIWLDV 203
 
Name Accession Description Interval E-value
p23_like cd06463
Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) ...
 84-170 5.49e-10

Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis. Both p23 and Sba1p can regulate telomerase activity. This group includes domains similar to the C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1). Sgt1 interacts with multiple protein complexes and has the features of a co-chaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has been shown to bind Hsp90 through its CS domain. Saccharomyces cerevisiae (Sc) Sgt1 is a subunit of both core kinetochore and SCF (Skp1-Cul1-F-box) ubiquitin ligase complexes. Sgt1 is required for pathogen resistance in plants. This group also includes the p23_like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR). hB-ind1 plays a role in the signaling pathway mediated by the small GTPase Rac1, NUDC is needed for nuclear movement, Melusin interacts with two splice variants of beta1 integrin, and NCB5OR plays a part in maintaining viable pancreatic beta cells.


Pssm-ID: 107220  Cd Length: 84  Bit Score: 55.37  E-value: 5.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242040065  84 FTDGNGEVELRLDIQKLgieSARDVFVDVDDTSLLIRAKSDGTLRTLMNVQtLFDRIKSSETIWFIDEDQLVVNLKKVEQ 163
Cdd:cd06463    1 WYQTLDEVTITIPLKDV---TKKDVKVEFTPKSLTVSVKGGGGKEYLLEGE-LFGPIDPEESKWTVEDRKIEITLKKKEP 76


                 ....*..
gi 242040065 164 ELKWPDI 170
Cdd:cd06463   77 GEWWPRL 83
PLN02199 PLN02199
shikimate kinase
 150-290 8.94e-07

shikimate kinase


Pssm-ID: 177850 [Multi-domain]  Cd Length: 303  Bit Score: 50.08  E-value: 8.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242040065 150 DEDQLvvnlKKVEQELKwpdideswesltsgitQLLTGISVHIVGDSTHINEAVAKEIAEGIGYLPVCTSELLESATQ-K 228
Cdd:PLN02199  85 DEDIL----KRKAEEVK----------------PYLNGRSMYLVGMMGSGKTTVGKLMSKVLGYTFFDCDTLIEQAMNgT 144

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 242040065 229 SIDTWVASEGADSVAEAESVVLESLSSHVRTVVATLGGkqgAASRFDRWQYLHSGFTVWLSV 290
Cdd:PLN02199 145 SVAEIFVHHGENFFRGKETDALKKLSSRYQVVVSTGGG---AVIRPINWKYMHKGISIWLDV 203
AroK COG0703
Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the ...
 203-291 1.34e-06

Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440467 [Multi-domain]  Cd Length: 165  Bit Score: 47.82  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242040065 203 VAKEIAEGIGYLPVCTSELLESATQKSIDTWVASEGADSVAEAESVVLESLSSHVRTVVATlGGkqGAASRFDRWQYLHS 282
Cdd:COG0703   14 VGRLLAKRLGLPFVDTDAEIEERAGMSIPEIFAEEGEAGFRELEREVLAELLEEENAVIAT-GG--GAVLSPENRELLKE 90

                         90
                 ....*....|
gi 242040065 283 -GFTVWLSVS 291
Cdd:COG0703   91 hGTVVYLDAS 100
SKI pfam01202
Shikimate kinase;
193-291 2.12e-06

Shikimate kinase;


Pssm-ID: 426122 [Multi-domain]  Cd Length: 159  Bit Score: 47.19  E-value: 2.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242040065  193 VGDSThineaVAKEIAEGIGYLPVCTSELLESATQKSIDTWVASEGADSVAEAESVVLESLSSHVRTVVATlGGkqGAAS 272
Cdd:pfam01202   3 AGKST-----IGRLLAKALGLPFIDTDEEIEKRTGMSIAEIFEEEGEEGFRRLESEVLKELLAEHGLVIAT-GG--GAVL 74

                          90       100
                  ....*....|....*....|
gi 242040065  273 RFDRWQYLHS-GFTVWLSVS 291
Cdd:pfam01202  75 SEENRDLLKErGIVIYLDAP 94
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 193-291 1.08e-05

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 45.24  E-value: 1.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242040065 193 VGDSThineaVAKEIAEGIGYLPVCTSELLESATQKSIDTWVASEGADSVAEAESVVLESLSSHVRTVVATlGGkqGAAS 272
Cdd:cd00464   10 AGKTT-----VGRLLAKALGLPFVDLDELIEQRAGMSIPEIFAEEGEEGFRELEREVLLLLLTKENAVIAT-GG--GAVL 81

                         90       100
                 ....*....|....*....|
gi 242040065 273 RFD-RWQYLHSGFTVWLSVS 291
Cdd:cd00464   82 REEnRRLLLENGIVVWLDAS 101
 
Name Accession Description Interval E-value
p23_like cd06463
Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) ...
 84-170 5.49e-10

Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis. Both p23 and Sba1p can regulate telomerase activity. This group includes domains similar to the C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1). Sgt1 interacts with multiple protein complexes and has the features of a co-chaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has been shown to bind Hsp90 through its CS domain. Saccharomyces cerevisiae (Sc) Sgt1 is a subunit of both core kinetochore and SCF (Skp1-Cul1-F-box) ubiquitin ligase complexes. Sgt1 is required for pathogen resistance in plants. This group also includes the p23_like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR). hB-ind1 plays a role in the signaling pathway mediated by the small GTPase Rac1, NUDC is needed for nuclear movement, Melusin interacts with two splice variants of beta1 integrin, and NCB5OR plays a part in maintaining viable pancreatic beta cells.


Pssm-ID: 107220  Cd Length: 84  Bit Score: 55.37  E-value: 5.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242040065  84 FTDGNGEVELRLDIQKLgieSARDVFVDVDDTSLLIRAKSDGTLRTLMNVQtLFDRIKSSETIWFIDEDQLVVNLKKVEQ 163
Cdd:cd06463    1 WYQTLDEVTITIPLKDV---TKKDVKVEFTPKSLTVSVKGGGGKEYLLEGE-LFGPIDPEESKWTVEDRKIEITLKKKEP 76


                 ....*..
gi 242040065 164 ELKWPDI 170
Cdd:cd06463   77 GEWWPRL 83
p23_NUDC_like cd06467
p23_like domain of NUD (nuclear distribution) C and similar proteins. Aspergillus nidulas (An) ...
 82-170 9.91e-10

p23_like domain of NUD (nuclear distribution) C and similar proteins. Aspergillus nidulas (An) NUDC is needed for nuclear movement. AnNUDC is localized at the hyphal cortex, and binds NUDF at spindle pole bodies (SPBs) and in the cytoplasm at different stages in the cell cycle. At the SPBs it is part of the dynein molecular motor/NUDF complex that regulates microtubule dynamics. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) complex, through binding mNUDF, the regulatory beta subunit of PAF-AH(I). mNUDC is important for cell proliferation both in normal and tumor tissues. Its expression is elevated in various cell types undergoing mitosis or stimulated to proliferate, with high expression levels observed in leukemic cells and tumors. For a leukemic cell line, human NUDC was shown to activate the thrombopoietin (TPO) receptor (Mpl) by binding to its extracellular domain, and promoting cell proliferation and differentiation. This group also includes the human broadly immunogenic tumor associated antigen, CML66, which is highly expressed in a variety of solid tumors and in leukemias. In normal tissues high expression of CML66 is limited to testis and heart.


Pssm-ID: 107224  Cd Length: 85  Bit Score: 54.86  E-value: 9.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242040065  82 YEFTDGNGEVELRLDIQKlGIeSARDVFVDVDDTSLLIRAKSDgtlRTLMNVQtLFDRIKSSETIWFI-DEDQLVVNLKK 160
Cdd:cd06467    1 YSWTQTLDEVTVTIPLPE-GT-KSKDVKVEITPKHLKVGVKGG---EPLLDGE-LYAKVKVDESTWTLeDGKLLEITLEK 74

                         90
                 ....*....|
gi 242040065 161 VEQELKWPDI 170
Cdd:cd06467   75 RNEGEWWPSL 84
PLN02199 PLN02199
shikimate kinase
 150-290 8.94e-07

shikimate kinase


Pssm-ID: 177850 [Multi-domain]  Cd Length: 303  Bit Score: 50.08  E-value: 8.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242040065 150 DEDQLvvnlKKVEQELKwpdideswesltsgitQLLTGISVHIVGDSTHINEAVAKEIAEGIGYLPVCTSELLESATQ-K 228
Cdd:PLN02199  85 DEDIL----KRKAEEVK----------------PYLNGRSMYLVGMMGSGKTTVGKLMSKVLGYTFFDCDTLIEQAMNgT 144

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 242040065 229 SIDTWVASEGADSVAEAESVVLESLSSHVRTVVATLGGkqgAASRFDRWQYLHSGFTVWLSV 290
Cdd:PLN02199 145 SVAEIFVHHGENFFRGKETDALKKLSSRYQVVVSTGGG---AVIRPINWKYMHKGISIWLDV 203
AroK COG0703
Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the ...
 203-291 1.34e-06

Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440467 [Multi-domain]  Cd Length: 165  Bit Score: 47.82  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242040065 203 VAKEIAEGIGYLPVCTSELLESATQKSIDTWVASEGADSVAEAESVVLESLSSHVRTVVATlGGkqGAASRFDRWQYLHS 282
Cdd:COG0703   14 VGRLLAKRLGLPFVDTDAEIEERAGMSIPEIFAEEGEAGFRELEREVLAELLEEENAVIAT-GG--GAVLSPENRELLKE 90

                         90
                 ....*....|
gi 242040065 283 -GFTVWLSVS 291
Cdd:COG0703   91 hGTVVYLDAS 100
SKI pfam01202
Shikimate kinase;
193-291 2.12e-06

Shikimate kinase;


Pssm-ID: 426122 [Multi-domain]  Cd Length: 159  Bit Score: 47.19  E-value: 2.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242040065  193 VGDSThineaVAKEIAEGIGYLPVCTSELLESATQKSIDTWVASEGADSVAEAESVVLESLSSHVRTVVATlGGkqGAAS 272
Cdd:pfam01202   3 AGKST-----IGRLLAKALGLPFIDTDEEIEKRTGMSIAEIFEEEGEEGFRRLESEVLKELLAEHGLVIAT-GG--GAVL 74

                          90       100
                  ....*....|....*....|
gi 242040065  273 RFDRWQYLHS-GFTVWLSVS 291
Cdd:pfam01202  75 SEENRDLLKErGIVIYLDAP 94
aroK PRK00131
shikimate kinase; Reviewed
 193-291 1.07e-05

shikimate kinase; Reviewed


Pssm-ID: 234654 [Multi-domain]  Cd Length: 175  Bit Score: 45.57  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242040065 193 VGDSThineaVAKEIAEGIGYLPVCTSELLESATQKSIDTWVASEGADSVAEAESVVLESLSSHVRTVVATlGGkqGAAS 272
Cdd:PRK00131  15 AGKST-----IGRLLAKRLGYDFIDTDHLIEARAGKSIPEIFEEEGEAAFRELEEEVLAELLARHNLVIST-GG--GAVL 86

                         90       100
                 ....*....|....*....|
gi 242040065 273 RFDRWQYL-HSGFTVWLSVS 291
Cdd:PRK00131  87 REENRALLrERGTVVYLDAS 106
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 193-291 1.08e-05

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 45.24  E-value: 1.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242040065 193 VGDSThineaVAKEIAEGIGYLPVCTSELLESATQKSIDTWVASEGADSVAEAESVVLESLSSHVRTVVATlGGkqGAAS 272
Cdd:cd00464   10 AGKTT-----VGRLLAKALGLPFVDLDELIEQRAGMSIPEIFAEEGEEGFRELEREVLLLLLTKENAVIAT-GG--GAVL 81

                         90       100
                 ....*....|....*....|
gi 242040065 273 RFD-RWQYLHSGFTVWLSVS 291
Cdd:cd00464   82 REEnRRLLLENGIVVWLDAS 101
p23_CacyBP cd06468
p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP) ...
 80-170 2.21e-03

p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP)/Siah-1-interacting protein (SIP). CacyBP/SIP interacts with S100A6 (calcyclin), with some other members of the S100 family, with tubulin, and with Siah-1 and Skp-1. The latter two are components of the ubiquitin ligase that regulates beta-catenin degradation. The beta-catenin gene is an oncogene participating in tumorigenesis in many different cancers. Overexpression of CacyBP/SIP, in part through its effect on the expression of beta-catenin, inhibits the proliferation, tumorigenicity, and invasion of gastric cancer cells. CacyBP/SIP is abundant in neurons and neuroblastoma NB2a cells. An extensive re-organization of microtubules accompanies the differentiation of NB2a cells. CacyBP/SIP may contribute to NB2a cell differentiation through binding to and increasing the oligomerization of tubulin. CacyBP/SIP is also implicated in differentiation of erythroid cells, rat neonatal cardiomyocytes, in mouse endometrial events, and in thymocyte development.


Pssm-ID: 107225  Cd Length: 92  Bit Score: 36.86  E-value: 2.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242040065  80 KDYEFTDGNGEVELRLDIQKLGIESARDVFVDVDDTSLLIRAKSDGTLRTLMNVQTLFDRIKSSETIWFIDEDQLVVNLK 159
Cdd:cd06468    2 TKYAWDQSDKFVKIYITLKGVHQLPKENIQVEFTERSFELKVHDLNGKNYRFTINRLLKKIDPEKSSFKVKTDRIVITLA 81

                         90
                 ....*....|.
gi 242040065 160 KVEqELKWPDI 170
Cdd:cd06468   82 KKK-EKKWESL 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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