NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|223996875|ref|XP_002288111|]
View 

predicted protein, partial [Thalassiosira pseudonana CCMP1335]

Protein Classification

PLP-dependent aminotransferase family protein( domain architecture ID 139552)

PLP-dependent aminotransferase family protein may combine pyridoxal phosphate with an alpha-amino acid to form a Schiff base or aldimine intermediate, which then acts as the substrate in a reaction such as a transamination, racemization, or decarboxylation

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AAT_I super family cl18945
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 1-372 0e+00

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


The actual alignment was detected with superfamily member PLN02452:

Pssm-ID: 450240  Cd Length: 365  Bit Score: 562.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875   1 KVLNFSPGPTNLPPAVEAAIKQRCFpSPEEKRLGSMALSHRSPEFGTILRRTLALTRKVMKIPDEYEVLFMQGGGHGQFA 80
Cdd:PLN02452   7 RVFNFSAGPATLPANVLAKAQAELY-NWEGSGMSVMEMSHRGKEFLSIIQKAEADLRELLDIPDNYEVLFLQGGASTQFA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875  81 AVPMNLCSNGsEKATYIINGTWSARAVEEAKKYCDPTVISSvNNDGTYTAFPSVERIEneMDPNSKFLYLCSNETVNGIE 160
Cdd:PLN02452  86 AIPLNLCKPG-DKADFVVTGSWSKKAAKEAKKYCKTNVIAS-GKDEKYTKIPSVSEWE--LTPDAKFVHICANETIHGVE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875 161 LHSLPRFS-VPLVVDASSDFSSKPITwyESNIGILFACASKNIGHPGVTIVVIRKDLLGNANPFTPGIFNYETNVLAENV 239
Cdd:PLN02452 162 FKDYPDVGnVPLVADMSSNFLSKPVD--VSKYGVIYAGAQKNVGPSGVTIVIIRKDLIGNARPITPGMLDYKIHAENDSL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875 240 WNTIPTFNVDVIGIVMEWLLENGGMNAMESLSIAKSDLLYDLIDNSNGFYSTPVarESGYRSRMNIPFNIGGGseELTDL 319
Cdd:PLN02452 240 YNTPPCFGIYMCGLVFEDLLAQGGLKAMEKRNIRKADLLYDAIDESNGFYVCPV--EKSVRSLMNVPFTLGGS--ELEAE 315

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 223996875 320 FLVECWNRGIVGLRTVTPFAKsmfLRASLYHGVAYDEVVVLAQFMKSFAAKHS 372
Cdd:PLN02452 316 FVKEAAKAGMVQLKGHRSVGG---MRASIYNAMPLAGVEKLVAFMKDFQAKHA 365
 
Name Accession Description Interval E-value
PLN02452 PLN02452
phosphoserine transaminase
 1-372 0e+00

phosphoserine transaminase


Pssm-ID: 178071  Cd Length: 365  Bit Score: 562.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875   1 KVLNFSPGPTNLPPAVEAAIKQRCFpSPEEKRLGSMALSHRSPEFGTILRRTLALTRKVMKIPDEYEVLFMQGGGHGQFA 80
Cdd:PLN02452   7 RVFNFSAGPATLPANVLAKAQAELY-NWEGSGMSVMEMSHRGKEFLSIIQKAEADLRELLDIPDNYEVLFLQGGASTQFA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875  81 AVPMNLCSNGsEKATYIINGTWSARAVEEAKKYCDPTVISSvNNDGTYTAFPSVERIEneMDPNSKFLYLCSNETVNGIE 160
Cdd:PLN02452  86 AIPLNLCKPG-DKADFVVTGSWSKKAAKEAKKYCKTNVIAS-GKDEKYTKIPSVSEWE--LTPDAKFVHICANETIHGVE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875 161 LHSLPRFS-VPLVVDASSDFSSKPITwyESNIGILFACASKNIGHPGVTIVVIRKDLLGNANPFTPGIFNYETNVLAENV 239
Cdd:PLN02452 162 FKDYPDVGnVPLVADMSSNFLSKPVD--VSKYGVIYAGAQKNVGPSGVTIVIIRKDLIGNARPITPGMLDYKIHAENDSL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875 240 WNTIPTFNVDVIGIVMEWLLENGGMNAMESLSIAKSDLLYDLIDNSNGFYSTPVarESGYRSRMNIPFNIGGGseELTDL 319
Cdd:PLN02452 240 YNTPPCFGIYMCGLVFEDLLAQGGLKAMEKRNIRKADLLYDAIDESNGFYVCPV--EKSVRSLMNVPFTLGGS--ELEAE 315

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 223996875 320 FLVECWNRGIVGLRTVTPFAKsmfLRASLYHGVAYDEVVVLAQFMKSFAAKHS 372
Cdd:PLN02452 316 FVKEAAKAGMVQLKGHRSVGG---MRASIYNAMPLAGVEKLVAFMKDFQAKHA 365
SerC COG1932
Phosphoserine aminotransferase [Coenzyme transport and metabolism, Amino acid transport and ...
 1-371 1.08e-137

Phosphoserine aminotransferase [Coenzyme transport and metabolism, Amino acid transport and metabolism]; Phosphoserine aminotransferase is part of the Pathway/BioSystem: Serine biosynthesis


Pssm-ID: 441535  Cd Length: 358  Bit Score: 395.98  E-value: 1.08e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875   1 KVLNFSPGPTNLPPAVEAAIKQRcFPSPEEKRLGSMALSHRSPEFGTILRRTLALTRKVMKIPDEYEVLFMQGGGHGQFA 80
Cdd:COG1932    2 RVYNFSAGPAKLPEEVLEQAQAE-LLDWNGSGMSVMEMSHRSKPFKAIVEEAEADLRELLGIPDGYEVLFLQGGATAQFA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875  81 AVPMNLCsNGSEKATYIINGTWSARAVEEAKKYCDPTVISSvNNDGTYTAFPSVEriENEMDPNSKFLYLCSNETVNGIE 160
Cdd:COG1932   81 MVPMNLL-RGGKKADYLVTGEWSKKAIKEAKKYGEVNVVAS-SEDDNFGYIPKPE--EWQLSPDADYVHYTSNETITGVE 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875 161 LHSLPRF-SVPLVVDASSDFSSKPITWyeSNIGILFACASKNIGHPGVTIVVIRKDLLGNANPFTPGIFNYETNVLAENV 239
Cdd:COG1932  157 FHELPDVgDVPLVADMSSDILSRPVDV--SKFGLIYAGAQKNIGPAGLTVVIVRPDLLGRAERAIPSMLDYKTHADNDSM 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875 240 WNTIPTFNVDVIGIVMEWLLENGGMNAMESLSIAKSDLLYDLIDNSNgFYSTPVAREsgYRSRMNIPFNIggGSEELTDL 319
Cdd:COG1932  235 YNTPPTFAIYLAGLVLKWLKEQGGLAAMEKRNAEKAALLYDWIDASD-FYTNPVDPE--DRSRMNVTFDL--ADEELDAA 309

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 223996875 320 FLVECWNRGIVGL---RTVTPfaksmfLRASLYHGVAYDEVVVLAQFMKSFAAKH 371
Cdd:COG1932  310 FLAEAKAAGLVGLkghRSVGG------MRASIYNAMPLEGVEALVDFMDEFERRH 358
PSAT_like cd00611
Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP) ...
 4-368 1.22e-129

Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as a dimer and catalyzes the conversion of phosphohydroxypyruvate to phosphoserine.


Pssm-ID: 99736 [Multi-domain]  Cd Length: 355  Bit Score: 375.48  E-value: 1.22e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875   4 NFSPGPTNLPPAV--EAAIKQRCFpspEEKRLGSMALSHRSPEFGTILRRTLALTRKVMKIPDEYEVLFMQGGGHGQFAA 81
Cdd:cd00611    2 NFSAGPAALPEEVleQAQKELLDF---NGLGMSVMEMSHRSKDFEAIVNEAESDLRELLNIPDNYKVLFLQGGATGQFAA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875  82 VPMNLCSnGSEKATYIINGTWSARAVEEAKKYCDPTVISSVNNDGTYTAFPSVERIEneMDPNSKFLYLCSNETVNGIEL 161
Cdd:cd00611   79 VPLNLLG-DKGTADYVVTGAWSAKAAKEAKRYGGVVVIVAAKEEGKYTKIPDVETWD--LAPDAAYVHYCSNETIHGVEF 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875 162 HSLPRF-SVPLVVDASSDFSSKPITWyeSNIGILFACASKNIGHPGVTIVVIRKDLLGNANPFTPGIFNYETNVLAENVW 240
Cdd:cd00611  156 DEVPDTgGVPLVADMSSNILSRPIDV--SKFGVIYAGAQKNLGPAGVTVVIVRKDLLGKARKITPSMLNYKTHADNNSLY 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875 241 NTIPTFNVDVIGIVMEWLLENGGMNAMESLSIAKSDLLYDLIDNSNGFYSTPVARESgyRSRMNIPFNIggGSEELTDLF 320
Cdd:cd00611  234 NTPPTFAIYMMGLVLKWLKEQGGVEAMEKRNRQKAQLLYDTIDNSNGFYRGPVDKRA--RSRMNVPFRL--GKEELEKEF 309

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 223996875 321 LVECWNRGIVGL---RTVTPFaksmflRASLYHGVAYDEVVVLAQFMKSFA 368
Cdd:cd00611  310 LKEAEAAGMIGLkghRSVGGI------RASIYNALSLEGVQALADFMKEFQ 354
serC_1 TIGR01364
phosphoserine aminotransferase; This model represents the common form of the phosphoserine ...
 33-371 1.87e-125

phosphoserine aminotransferase; This model represents the common form of the phosphoserine aminotransferase SerC. The phosphoserine aminotransferase of the archaeon Methanosarcina barkeri and putative phosphoserine aminotransferase of Mycobacterium tuberculosis are represented by separate models. All are members of the class V aminotransferases (pfam00266). [Amino acid biosynthesis, Serine family]


Pssm-ID: 130431  Cd Length: 349  Bit Score: 364.68  E-value: 1.87e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875   33 LGSMALSHRSPEFGTILRRTLALTRKVMKIPDEYEVLFMQGGGHGQFAAVPMNLCSNGsEKATYIINGTWSARAVEEAKK 112
Cdd:TIGR01364  23 MSVMEISHRSKEFEAVANEAESDLRELLNIPDNYEVLFLQGGATGQFAAVPLNLLAEG-KVADYIVTGAWSKKAAKEAKK 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875  113 YCDPTVISSvNNDGTYTAFPSVERIenEMDPNSKFLYLCSNETVNGIELHSLPRFS-VPLVVDASSDFSSKPITWyeSNI 191
Cdd:TIGR01364 102 YGVVNVVAS-GKEGNYTKIPDPSTW--EISEDAAYVHYCANETIHGVEFRELPDVKnAPLVADMSSNILSRPIDV--SKF 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875  192 GILFACASKNIGHPGVTIVVIRKDLLGNANPFTPGIFNYETNVLAENVWNTIPTFNVDVIGIVMEWLLENGGMNAMESLS 271
Cdd:TIGR01364 177 GLIYAGAQKNIGPAGLTVVIVRKDLLGRASRITPSMLNYKIHAENDSMYNTPPTFAIYVSGLVFKWLKEQGGVKAIEKRN 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875  272 IAKSDLLYDLIDNSNGFYSTPVAREsgYRSRMNIPFNIggGSEELTDLFLVECWNRGIVGL---RTVTPFaksmflRASL 348
Cdd:TIGR01364 257 QAKAQLLYDTIDNSNGFYRNPVDPR--NRSRMNVVFTL--GNEELEKRFLKEAEERGLVSLkghRSVGGM------RASI 326

                         330       340
                  ....*....|....*....|...
gi 223996875  349 YHGVAYDEVVVLAQFMKSFAAKH 371
Cdd:TIGR01364 327 YNAMPLEGVQALVDFMKEFQKKH 349
Aminotran_5 pfam00266
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ...
 2-350 4.18e-35

Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.


Pssm-ID: 425567 [Multi-domain]  Cd Length: 368  Bit Score: 131.99  E-value: 4.18e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875    2 VLNFSPGPTNLPPAVEAAIKQRcfpSPEEKRLGSMALSHRSPEFGTILRRTLALTRKVMKIPDEYEVLFMQGGGHgQFAA 81
Cdd:pfam00266   1 IYLDSAATTQKPQEVLDAIQEY---YTDYNGNVHRGVHTLGKEATQAYEEAREKVAEFINAPSNDEIIFTSGTTE-AINL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875   82 VPMNLCSNGSEKATYII--NGTWSAR-AVEEAKKYCDPTV-ISSVNNDGTYTafpsVERIENEMDPNSKFLYLCSNETVN 157
Cdd:pfam00266  77 VALSLGRSLKPGDEIVIteMEHHANLvPWQELAKRTGARVrVLPLDEDGLLD----LDELEKLITPKTKLVAITHVSNVT 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875  158 GIEL------HSLPRFSVPLVVDASSDFSSKPItwYESNIGILFACAS--KNIGHPGVTIVVIRKDLLGNANPFTPGIFN 229
Cdd:pfam00266 153 GTIQpvpeigKLAHQYGALVLVDAAQAIGHRPI--DVQKLGVDFLAFSghKLYGPTGIGVLYGRRDLLEKMPPLLGGGGM 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875  230 YETNVLAENVWNTIP------TFNV-DVIGI--VMEWlLENGGMNAMESLSIAKSDLLYDLIDNSNGFYstpVARESGYR 300
Cdd:pfam00266 231 IETVSLQESTFADAPwkfeagTPNIaGIIGLgaALEY-LSEIGLEAIEKHEHELAQYLYERLLSLPGIR---LYGPERRA 306

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 223996875  301 SRMNIPFNIGGGSEELTdlFLVEcwnRGI---VGLRTVTP----FAKSMFLRASLYH 350
Cdd:pfam00266 307 SIISFNFKGVHPHDVAT--LLDE---SGIavrSGHHCAQPlmvrLGLGGTVRASFYI 358
 
Name Accession Description Interval E-value
PLN02452 PLN02452
phosphoserine transaminase
 1-372 0e+00

phosphoserine transaminase


Pssm-ID: 178071  Cd Length: 365  Bit Score: 562.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875   1 KVLNFSPGPTNLPPAVEAAIKQRCFpSPEEKRLGSMALSHRSPEFGTILRRTLALTRKVMKIPDEYEVLFMQGGGHGQFA 80
Cdd:PLN02452   7 RVFNFSAGPATLPANVLAKAQAELY-NWEGSGMSVMEMSHRGKEFLSIIQKAEADLRELLDIPDNYEVLFLQGGASTQFA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875  81 AVPMNLCSNGsEKATYIINGTWSARAVEEAKKYCDPTVISSvNNDGTYTAFPSVERIEneMDPNSKFLYLCSNETVNGIE 160
Cdd:PLN02452  86 AIPLNLCKPG-DKADFVVTGSWSKKAAKEAKKYCKTNVIAS-GKDEKYTKIPSVSEWE--LTPDAKFVHICANETIHGVE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875 161 LHSLPRFS-VPLVVDASSDFSSKPITwyESNIGILFACASKNIGHPGVTIVVIRKDLLGNANPFTPGIFNYETNVLAENV 239
Cdd:PLN02452 162 FKDYPDVGnVPLVADMSSNFLSKPVD--VSKYGVIYAGAQKNVGPSGVTIVIIRKDLIGNARPITPGMLDYKIHAENDSL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875 240 WNTIPTFNVDVIGIVMEWLLENGGMNAMESLSIAKSDLLYDLIDNSNGFYSTPVarESGYRSRMNIPFNIGGGseELTDL 319
Cdd:PLN02452 240 YNTPPCFGIYMCGLVFEDLLAQGGLKAMEKRNIRKADLLYDAIDESNGFYVCPV--EKSVRSLMNVPFTLGGS--ELEAE 315

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 223996875 320 FLVECWNRGIVGLRTVTPFAKsmfLRASLYHGVAYDEVVVLAQFMKSFAAKHS 372
Cdd:PLN02452 316 FVKEAAKAGMVQLKGHRSVGG---MRASIYNAMPLAGVEKLVAFMKDFQAKHA 365
SerC COG1932
Phosphoserine aminotransferase [Coenzyme transport and metabolism, Amino acid transport and ...
 1-371 1.08e-137

Phosphoserine aminotransferase [Coenzyme transport and metabolism, Amino acid transport and metabolism]; Phosphoserine aminotransferase is part of the Pathway/BioSystem: Serine biosynthesis


Pssm-ID: 441535  Cd Length: 358  Bit Score: 395.98  E-value: 1.08e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875   1 KVLNFSPGPTNLPPAVEAAIKQRcFPSPEEKRLGSMALSHRSPEFGTILRRTLALTRKVMKIPDEYEVLFMQGGGHGQFA 80
Cdd:COG1932    2 RVYNFSAGPAKLPEEVLEQAQAE-LLDWNGSGMSVMEMSHRSKPFKAIVEEAEADLRELLGIPDGYEVLFLQGGATAQFA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875  81 AVPMNLCsNGSEKATYIINGTWSARAVEEAKKYCDPTVISSvNNDGTYTAFPSVEriENEMDPNSKFLYLCSNETVNGIE 160
Cdd:COG1932   81 MVPMNLL-RGGKKADYLVTGEWSKKAIKEAKKYGEVNVVAS-SEDDNFGYIPKPE--EWQLSPDADYVHYTSNETITGVE 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875 161 LHSLPRF-SVPLVVDASSDFSSKPITWyeSNIGILFACASKNIGHPGVTIVVIRKDLLGNANPFTPGIFNYETNVLAENV 239
Cdd:COG1932  157 FHELPDVgDVPLVADMSSDILSRPVDV--SKFGLIYAGAQKNIGPAGLTVVIVRPDLLGRAERAIPSMLDYKTHADNDSM 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875 240 WNTIPTFNVDVIGIVMEWLLENGGMNAMESLSIAKSDLLYDLIDNSNgFYSTPVAREsgYRSRMNIPFNIggGSEELTDL 319
Cdd:COG1932  235 YNTPPTFAIYLAGLVLKWLKEQGGLAAMEKRNAEKAALLYDWIDASD-FYTNPVDPE--DRSRMNVTFDL--ADEELDAA 309

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 223996875 320 FLVECWNRGIVGL---RTVTPfaksmfLRASLYHGVAYDEVVVLAQFMKSFAAKH 371
Cdd:COG1932  310 FLAEAKAAGLVGLkghRSVGG------MRASIYNAMPLEGVEALVDFMDEFERRH 358
PRK05355 PRK05355
3-phosphoserine/phosphohydroxythreonine transaminase;
1-372 4.81e-135

3-phosphoserine/phosphohydroxythreonine transaminase;


Pssm-ID: 235428  Cd Length: 360  Bit Score: 389.46  E-value: 4.81e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875   1 KVLNFSPGPTNLPPAV--EAaikQRCFPSPEEKRLGSMALSHRSPEFGTILRRTLALTRKVMKIPDEYEVLFMQGGGHGQ 78
Cdd:PRK05355   3 RVYNFSAGPAMLPEEVleQA---QQELLDWNGSGMSVMEISHRSKEFEAVAEEAEADLRELLNIPDNYKVLFLQGGASLQ 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875  79 FAAVPMNLcSNGSEKATYIINGTWSARAVEEAKKYCDPTVISSVNNDGtYTAFPSVEriENEMDPNSKFLYLCSNETVNG 158
Cdd:PRK05355  80 FAMVPMNL-LGGGKKADYVDTGSWSKKAIKEAKKYGEVNVAASSEDDG-FTYIPPLD--EWQLSDDAAYVHYTSNETIDG 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875 159 IELHSLPRFS-VPLVVDASSDFSSKPITWyeSNIGILFACASKNIGHPGVTIVVIRKDLLGNANPFTPGIFNYETNVLAE 237
Cdd:PRK05355 156 TEFHELPDTGdVPLVADMSSDILSRPIDV--SKFGLIYAGAQKNIGPAGLTIVIVREDLLGRALPSIPSMLDYKTHADND 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875 238 NVWNTIPTFNVDVIGIVMEWLLENGGMNAMESLSIAKSDLLYDLIDNSNgFYSTPVAREsgYRSRMNIPFNIggGSEELT 317
Cdd:PRK05355 234 SMYNTPPTFAIYLAGLVFKWLKEQGGVAAMEKRNQEKAALLYDAIDSSD-FYRNPVAPE--DRSRMNVPFTL--ADEELD 308

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 223996875 318 DLFLVECWNRGIVGL---RTVTPFaksmflRASLYHGVAYDEVVVLAQFMKSFAAKHS 372
Cdd:PRK05355 309 KKFLAEAKAAGLVGLkghRSVGGM------RASIYNAMPLEGVQALVDFMKEFERRHG 360
PSAT_like cd00611
Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP) ...
 4-368 1.22e-129

Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as a dimer and catalyzes the conversion of phosphohydroxypyruvate to phosphoserine.


Pssm-ID: 99736 [Multi-domain]  Cd Length: 355  Bit Score: 375.48  E-value: 1.22e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875   4 NFSPGPTNLPPAV--EAAIKQRCFpspEEKRLGSMALSHRSPEFGTILRRTLALTRKVMKIPDEYEVLFMQGGGHGQFAA 81
Cdd:cd00611    2 NFSAGPAALPEEVleQAQKELLDF---NGLGMSVMEMSHRSKDFEAIVNEAESDLRELLNIPDNYKVLFLQGGATGQFAA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875  82 VPMNLCSnGSEKATYIINGTWSARAVEEAKKYCDPTVISSVNNDGTYTAFPSVERIEneMDPNSKFLYLCSNETVNGIEL 161
Cdd:cd00611   79 VPLNLLG-DKGTADYVVTGAWSAKAAKEAKRYGGVVVIVAAKEEGKYTKIPDVETWD--LAPDAAYVHYCSNETIHGVEF 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875 162 HSLPRF-SVPLVVDASSDFSSKPITWyeSNIGILFACASKNIGHPGVTIVVIRKDLLGNANPFTPGIFNYETNVLAENVW 240
Cdd:cd00611  156 DEVPDTgGVPLVADMSSNILSRPIDV--SKFGVIYAGAQKNLGPAGVTVVIVRKDLLGKARKITPSMLNYKTHADNNSLY 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875 241 NTIPTFNVDVIGIVMEWLLENGGMNAMESLSIAKSDLLYDLIDNSNGFYSTPVARESgyRSRMNIPFNIggGSEELTDLF 320
Cdd:cd00611  234 NTPPTFAIYMMGLVLKWLKEQGGVEAMEKRNRQKAQLLYDTIDNSNGFYRGPVDKRA--RSRMNVPFRL--GKEELEKEF 309

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 223996875 321 LVECWNRGIVGL---RTVTPFaksmflRASLYHGVAYDEVVVLAQFMKSFA 368
Cdd:cd00611  310 LKEAEAAGMIGLkghRSVGGI------RASIYNALSLEGVQALADFMKEFQ 354
serC_1 TIGR01364
phosphoserine aminotransferase; This model represents the common form of the phosphoserine ...
 33-371 1.87e-125

phosphoserine aminotransferase; This model represents the common form of the phosphoserine aminotransferase SerC. The phosphoserine aminotransferase of the archaeon Methanosarcina barkeri and putative phosphoserine aminotransferase of Mycobacterium tuberculosis are represented by separate models. All are members of the class V aminotransferases (pfam00266). [Amino acid biosynthesis, Serine family]


Pssm-ID: 130431  Cd Length: 349  Bit Score: 364.68  E-value: 1.87e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875   33 LGSMALSHRSPEFGTILRRTLALTRKVMKIPDEYEVLFMQGGGHGQFAAVPMNLCSNGsEKATYIINGTWSARAVEEAKK 112
Cdd:TIGR01364  23 MSVMEISHRSKEFEAVANEAESDLRELLNIPDNYEVLFLQGGATGQFAAVPLNLLAEG-KVADYIVTGAWSKKAAKEAKK 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875  113 YCDPTVISSvNNDGTYTAFPSVERIenEMDPNSKFLYLCSNETVNGIELHSLPRFS-VPLVVDASSDFSSKPITWyeSNI 191
Cdd:TIGR01364 102 YGVVNVVAS-GKEGNYTKIPDPSTW--EISEDAAYVHYCANETIHGVEFRELPDVKnAPLVADMSSNILSRPIDV--SKF 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875  192 GILFACASKNIGHPGVTIVVIRKDLLGNANPFTPGIFNYETNVLAENVWNTIPTFNVDVIGIVMEWLLENGGMNAMESLS 271
Cdd:TIGR01364 177 GLIYAGAQKNIGPAGLTVVIVRKDLLGRASRITPSMLNYKIHAENDSMYNTPPTFAIYVSGLVFKWLKEQGGVKAIEKRN 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875  272 IAKSDLLYDLIDNSNGFYSTPVAREsgYRSRMNIPFNIggGSEELTDLFLVECWNRGIVGL---RTVTPFaksmflRASL 348
Cdd:TIGR01364 257 QAKAQLLYDTIDNSNGFYRNPVDPR--NRSRMNVVFTL--GNEELEKRFLKEAEERGLVSLkghRSVGGM------RASI 326

                         330       340
                  ....*....|....*....|...
gi 223996875  349 YHGVAYDEVVVLAQFMKSFAAKH 371
Cdd:TIGR01364 327 YNAMPLEGVQALVDFMKEFQKKH 349
PRK12462 PRK12462
phosphoserine aminotransferase; Provisional
 3-372 5.46e-86

phosphoserine aminotransferase; Provisional


Pssm-ID: 183540  Cd Length: 364  Bit Score: 264.75  E-value: 5.46e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875   3 LNFSPGPTNLPPAVEAAIKQRCFPSPEEKrLGSMALSHRSPEFGTILRRTLALTRKVMKIPDEYEVLFMQGGGHGQFAAV 82
Cdd:PRK12462   6 LNFSGGPGALPDTVLEQVRQAVVELPETG-LSVLGMSHRSSWFSSLLAQAEADLRDLLGIPDEYGVVFLQGGSSLQFSMI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875  83 PMNLCSNGSEKATYIINGTWSARAVEEAKKYCDPTVISSVNNDGtYTAFPSVEriENEMDPNSKFLYLCSNETVNGIELH 162
Cdd:PRK12462  85 PMNFSRPGAAAPEYVTTGYWSRKAIGEASRVAAMRVVWDGAASG-YRTLPSLA--ELDWDARAPFRHYVSNETVEGLQFP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875 163 SLP-RFSVPLVVDASSDFSSKPITwyESNIGILFACASKNIGHPGVTIVVIRKDLLGNANPFTPGIFNYETNVLAENVWN 241
Cdd:PRK12462 162 DAAgLPDSPLIADMSSDFMSRPFD--VEAYGMVYAHAQKNLGPAGVTVAIIRRALLERVPDTLPPMLDFRTHVEHRSNYN 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875 242 TIPTFNVDVIGIVMEWLLEN-GGMNAMESLSIAKSDLLYDLIDNSNGFYSTPVARESgyRSRMNIPFNIggGSEELTDLF 320
Cdd:PRK12462 240 TPPVFAIYVMALVLRWIRDEiGGVHAMRDINARKAAMLYATLDALNEVIDCHAHRAA--RSTMNVAFRF--RQPRLDTLF 315

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 223996875 321 LVECWNRGIVGL---RTVTPfaksmfLRASLYHGVAYDEVVVLAQFMKSFAAKHS 372
Cdd:PRK12462 316 KEQSTEAGFCGLsghRSIGG------IRASLYNAVSEQAVSRLCAFLKDFAIRHA 364
Aminotran_5 pfam00266
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ...
 2-350 4.18e-35

Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.


Pssm-ID: 425567 [Multi-domain]  Cd Length: 368  Bit Score: 131.99  E-value: 4.18e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875    2 VLNFSPGPTNLPPAVEAAIKQRcfpSPEEKRLGSMALSHRSPEFGTILRRTLALTRKVMKIPDEYEVLFMQGGGHgQFAA 81
Cdd:pfam00266   1 IYLDSAATTQKPQEVLDAIQEY---YTDYNGNVHRGVHTLGKEATQAYEEAREKVAEFINAPSNDEIIFTSGTTE-AINL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875   82 VPMNLCSNGSEKATYII--NGTWSAR-AVEEAKKYCDPTV-ISSVNNDGTYTafpsVERIENEMDPNSKFLYLCSNETVN 157
Cdd:pfam00266  77 VALSLGRSLKPGDEIVIteMEHHANLvPWQELAKRTGARVrVLPLDEDGLLD----LDELEKLITPKTKLVAITHVSNVT 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875  158 GIEL------HSLPRFSVPLVVDASSDFSSKPItwYESNIGILFACAS--KNIGHPGVTIVVIRKDLLGNANPFTPGIFN 229
Cdd:pfam00266 153 GTIQpvpeigKLAHQYGALVLVDAAQAIGHRPI--DVQKLGVDFLAFSghKLYGPTGIGVLYGRRDLLEKMPPLLGGGGM 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875  230 YETNVLAENVWNTIP------TFNV-DVIGI--VMEWlLENGGMNAMESLSIAKSDLLYDLIDNSNGFYstpVARESGYR 300
Cdd:pfam00266 231 IETVSLQESTFADAPwkfeagTPNIaGIIGLgaALEY-LSEIGLEAIEKHEHELAQYLYERLLSLPGIR---LYGPERRA 306

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 223996875  301 SRMNIPFNIGGGSEELTdlFLVEcwnRGI---VGLRTVTP----FAKSMFLRASLYH 350
Cdd:pfam00266 307 SIISFNFKGVHPHDVAT--LLDE---SGIavrSGHHCAQPlmvrLGLGGTVRASFYI 358
PucG COG0075
Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism ...
 3-217 3.45e-15

Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism protein PucG [Amino acid transport and metabolism, Nucleotide transport and metabolism]; Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism protein PucG is part of the Pathway/BioSystem: Serine biosynthesis


Pssm-ID: 439845 [Multi-domain]  Cd Length: 376  Bit Score: 75.90  E-value: 3.45e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875   3 LNFSPGPTNLPPAVEAAIKQRcfpspeekrlgsmALSHRSPEFGTILRRTLALTRKVMKipDEYEVLFMQGGGHGQFAAV 82
Cdd:COG0075    2 LLLTPGPTPVPPRVLRAMARP-------------MIGHRDPEFVELMDEVRELLKKVFG--TENDVVILTGSGTGAMEAA 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875  83 PMNLCSNGsEKATYIINGTWSARAVEEAKKY-CDPTVIssvnnDGTYTAFPSVERIENEM--DPNSKFLYLCSNETVNGI 159
Cdd:COG0075   67 LANLVSPG-DKVLVLVNGAFGERWAEIAERYgAEVVVL-----EVPWGEAVDPEEVEEALaaDPDIKAVAVVHNETSTGV 140

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 223996875 160 eLHSLP-------RFSVPLVVDASSDFSSKPI---TWyesNIGILFACASKNI-GHPGVTIVVIRKDLL 217
Cdd:COG0075  141 -LNPLEeigalakEHGALLIVDAVSSLGGVPLdmdEW---GIDVVVSGSQKCLmLPPGLAFVAVSERAL 205
AGAT_like cd06451
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate ...
 5-212 1.56e-13

Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-glyoxylate aminotransferase (SGAT), and 3-hydroxykynurenine transaminase (HKT). AGAT is a homodimeric protein, which catalyses the transamination of glyoxylate to glycine, and SGAT converts serine and glyoxylate to hydroxypyruvate and glycine. HKT catalyzes the PLP-dependent transamination of 3-hydroxykynurenine, a potentially toxic metabolite of the kynurenine pathway.


Pssm-ID: 99744 [Multi-domain]  Cd Length: 356  Bit Score: 70.78  E-value: 1.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875   5 FSPGPTNLPPAVEAAIKQrcfpspeekrlgSMaLSHRSPEFGTILRRTLALTRKVMKiPDEYEVLFMQGGGHGQFAAVPM 84
Cdd:cd06451    3 LIPGPSNVPPRVLKAMNR------------PM-LGHRSPEFLALMDEILEGLRYVFQ-TENGLTFLLSGSGTGAMEAALS 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875  85 NLCSNGsEKATYIINGTWSARAVEEAKKY-CDPTVISSVNNDGTytafpSVERIENEMDPNS-KFLYLCSNETVNGIeLH 162
Cdd:cd06451   69 NLLEPG-DKVLVGVNGVFGDRWADMAERYgADVDVVEKPWGEAV-----SPEEIAEALEQHDiKAVTLTHNETSTGV-LN 141

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 223996875 163 SLPRFS-------VPLVVDASSDFSSKPITWYESNIGILFACASKNIGHP-GVTIVVI 212
Cdd:cd06451  142 PLEGIGalakkhdALLIVDAVSSLGGEPFRMDEWGVDVAYTGSQKALGAPpGLGPIAF 199
AAT_I cd01494
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 63-213 3.35e-07

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


Pssm-ID: 99742 [Multi-domain]  Cd Length: 170  Bit Score: 49.69  E-value: 3.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875  63 PDEYEVLFmQGGGHGQFAAVPMNLCSNGSEkATYIINGTWSARAVEEAKKYCDPTVIssVNNDGTYTAFPSVERIENEMD 142
Cdd:cd01494   15 PGNDKAVF-VPSGTGANEAALLALLGPGDE-VIVDANGHGSRYWVAAELAGAKPVPV--PVDDAGYGGLDVAILEELKAK 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875 143 PNSKFLYLCSNETVNGI-----ELHSLP-RFSVPLVVDASSDFSSKPITWY---ESNIGILFACASKNIGHPGVTIVVIR 213
Cdd:cd01494   91 PNVALIVITPNTTSGGVlvplkEIRKIAkEYGILLLVDAASAGGASPAPGVlipEGGADVVTFSLHKNLGGEGGGVVIVK 170
PLN02409 PLN02409
serine--glyoxylate aminotransaminase
 5-159 2.34e-05

serine--glyoxylate aminotransaminase


Pssm-ID: 178031 [Multi-domain]  Cd Length: 401  Bit Score: 45.90  E-value: 2.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875   5 FSPGPTNLPPAVEAAIKQrcfpsPEEkrlgsmalSHRSPEFGTILRRTLALTRKVMKIPDEYEVLFmQGGGHGQFAAVPM 84
Cdd:PLN02409  13 FVPGPVNIPERVLRAMNR-----PNE--------DHRSPAFPALTKELLEDVKYIFKTKSGTPFIF-PTTGTGAWESALT 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 223996875  85 NLCSNGSEKATYIInGTWSARAVEEAKKY-CDPTVISSVNNDG-TYTAFPSVERIENEMDPnsKFLYLCSNETVNGI 159
Cdd:PLN02409  79 NTLSPGDKVVSFRI-GQFSLLWIDQMQRLnFDVDVVESPWGQGaDLDILKSKLRQDTNHKI--KAVCVVHNETSTGV 152
PRK03080 PRK03080
phosphoserine transaminase;
4-121 4.25e-04

phosphoserine transaminase;


Pssm-ID: 235103  Cd Length: 378  Bit Score: 42.10  E-value: 4.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875   4 NFSPGPTNLPPAveaaikqrcfPSPEEKRLGSMALSHRSPEFGTILRRTLALTRKVMKIPDEYEVLFMQGGGHGqfaAVP 83
Cdd:PRK03080  15 RFSSGPCKKRPG----------WQLEALADALLGRSHRQKPVKALLKRVIEGTRELLSLPEGYEVGIVPGSDTG---AWE 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 223996875  84 MNLCSN-GSEKATYIINGTWS---ARAVEEAKKYCDPTVISS 121
Cdd:PRK03080  82 MALWSLlGARRVDHLAWESFGskwATDVVKQLKLEDPRVLEA 123
PRK13479 PRK13479
2-aminoethylphosphonate--pyruvate transaminase; Provisional
 64-220 4.75e-03

2-aminoethylphosphonate--pyruvate transaminase; Provisional


Pssm-ID: 184076 [Multi-domain]  Cd Length: 368  Bit Score: 38.74  E-value: 4.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875  64 DEYEVLFMQGGGhgQFA-------AVPMNlcsngsEKATYIINGTWSARAVEEAKKYCDPTVISSVNNDgtytAFPSVER 136
Cdd:PRK13479  54 EGYTCVPLQGSG--TFSveaaigsLVPRD------GKVLVPDNGAYGARIAQIAEYLGIAHVVLDTGED----EPPDAAE 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223996875 137 IEN--EMDPNSKFLYLCSNETVNGIeLHSLP-------RFSVPLVVDASSDFSSKPITWYESNIGILFACASKNI-GHPG 206
Cdd:PRK13479 122 VEAalAADPRITHVALVHCETTTGI-LNPLDeiaavakRHGKRLIVDAMSSFGAIPIDIAELGIDALISSANKCIeGVPG 200

                        170
                 ....*....|....*...
gi 223996875 207 VTIVVIRKDLL----GNA 220
Cdd:PRK13479 201 FGFVIARRSELeackGNS 218
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH