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Conserved domains on  [gi|156356437|ref|XP_001623930|]
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neuralized-like protein 2 [Nematostella vectensis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 3-194 1.92e-57

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 179.63  E-value: 1.92e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156356437   3 RFHPKHGSHITLSPCQTVATRCK-SFANAVVFSNRPLSTSETFVFEIYEQEQGWSGHVRCGVTTHNPNFIKVPPyLLPDL 81
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATRVKaSFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPP-SATDL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156356437  82 AQmgTTWVFAlkPSNNKPLGDEQLRECGHNYQRLPqedevdntiycgekaatnsnirptdEGSRIGIRVSYAGNLYFYIN 161
Cdd:cd12887   80 KS--GTWILS--GSSVFKNGNKIRENYGPDLDRLR-------------------------VGDRVGVMRTSDGTLHFYVN 130

                        170       180       190
                 ....*....|....*....|....*....|...
gi 156356437 162 GKKFGPCATDLPSDseLFVTLDVYGSTKAVKII 194
Cdd:cd12887  131 GEDQGVAASNVPQP--VYAVVDLYGQCEQVSIV 161
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 199-235 9.52e-06

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239641  Cd Length: 41  Bit Score: 41.69  E-value: 9.52e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 156356437 199 VPSLLNLCCSKIRILT---LEGSIKSLPIPKLLKQYILSF 235
Cdd:cd03587    2 PRSLQHLCRLAIRRCLgkrRLDLIDKLPLPPRLKDYLLYK 41
 
Name Accession Description Interval E-value
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 3-194 1.92e-57

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 179.63  E-value: 1.92e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156356437   3 RFHPKHGSHITLSPCQTVATRCK-SFANAVVFSNRPLSTSETFVFEIYEQEQGWSGHVRCGVTTHNPNFIKVPPyLLPDL 81
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATRVKaSFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPP-SATDL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156356437  82 AQmgTTWVFAlkPSNNKPLGDEQLRECGHNYQRLPqedevdntiycgekaatnsnirptdEGSRIGIRVSYAGNLYFYIN 161
Cdd:cd12887   80 KS--GTWILS--GSSVFKNGNKIRENYGPDLDRLR-------------------------VGDRVGVMRTSDGTLHFYVN 130

                        170       180       190
                 ....*....|....*....|....*....|...
gi 156356437 162 GKKFGPCATDLPSDseLFVTLDVYGSTKAVKII 194
Cdd:cd12887  131 GEDQGVAASNVPQP--VYAVVDLYGQCEQVSIV 161
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 4-194 1.14e-41

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 138.82  E-value: 1.14e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156356437    4 FHPKHGSHITLSPCQTVATRCKSFANAVVFSNRPLSTSETFVFEIYEQEQGWSGHVRCGVTTHNPNfiKVPPYLLPDLAQ 83
Cdd:pfam07177   1 FHPVHGKNVRLSNDGRTARRTNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPA--TLRPKALPDLAT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156356437   84 --MGTTWVfalkpsnnKPLGDEQLRecghnyqrlpqedevdntiycgekaatnsnirptdEGSRIGIRVSYAGNLYFYIN 161
Cdd:pfam07177  79 dlRPGYWV--------VALSGSYLQ-----------------------------------EGDRLGFWVTSDGELHFSVN 115

                         170       180       190
                  ....*....|....*....|....*....|...
gi 156356437  162 GKKFGPCATDLPSDSELFVTLDVYGSTKAVKII 194
Cdd:pfam07177 116 GEDQGVALSGVPDSQPLWAVFDLYGQTTQVSIL 148
NEUZ smart00588
domain in neuralized proteins;
3-92 1.04e-25

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 97.00  E-value: 1.04e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156356437     3 RFHPKHGSHITLSPCQTVATRCKS-FANAVVFSNRPLSTSETFVFEIYEQEQGWSGHVRCGVTTHNPNFIKVPP---YLL 78
Cdd:smart00588   4 RFHHRHGSNIRLSDSGRVARRSASdFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASlptNAC 83

                           90
                   ....*....|....
gi 156356437    79 PDLAQMGTTWVFAL 92
Cdd:smart00588  84 PDLVDMSGFWAKAL 97
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 199-235 9.52e-06

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 41.69  E-value: 9.52e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 156356437 199 VPSLLNLCCSKIRILT---LEGSIKSLPIPKLLKQYILSF 235
Cdd:cd03587    2 PRSLQHLCRLAIRRCLgkrRLDLIDKLPLPPRLKDYLLYK 41
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 199-233 1.28e-05

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 41.00  E-value: 1.28e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 156356437  199 VPSLLNLCCSKIRILT---LEGSIKSLPIPKLLKQYIL 233
Cdd:pfam07525   2 PRSLQHLCRLAIRRALgkrRLGAIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 200-235 2.66e-05

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 40.08  E-value: 2.66e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 156356437   200 PSLLNLCCSKIRilTLEGSIKSLPIPKLLKQYILSF 235
Cdd:smart00969   1 RSLQHLCRLAIR--RSLGGIDKLPLPPRLKDYLLYY 34
 
Name Accession Description Interval E-value
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 3-194 1.92e-57

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 179.63  E-value: 1.92e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156356437   3 RFHPKHGSHITLSPCQTVATRCK-SFANAVVFSNRPLSTSETFVFEIYEQEQGWSGHVRCGVTTHNPNFIKVPPyLLPDL 81
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATRVKaSFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPP-SATDL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156356437  82 AQmgTTWVFAlkPSNNKPLGDEQLRECGHNYQRLPqedevdntiycgekaatnsnirptdEGSRIGIRVSYAGNLYFYIN 161
Cdd:cd12887   80 KS--GTWILS--GSSVFKNGNKIRENYGPDLDRLR-------------------------VGDRVGVMRTSDGTLHFYVN 130

                        170       180       190
                 ....*....|....*....|....*....|...
gi 156356437 162 GKKFGPCATDLPSDseLFVTLDVYGSTKAVKII 194
Cdd:cd12887  131 GEDQGVAASNVPQP--VYAVVDLYGQCEQVSIV 161
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 4-194 1.14e-41

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 138.82  E-value: 1.14e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156356437    4 FHPKHGSHITLSPCQTVATRCKSFANAVVFSNRPLSTSETFVFEIYEQEQGWSGHVRCGVTTHNPNfiKVPPYLLPDLAQ 83
Cdd:pfam07177   1 FHPVHGKNVRLSNDGRTARRTNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPA--TLRPKALPDLAT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156356437   84 --MGTTWVfalkpsnnKPLGDEQLRecghnyqrlpqedevdntiycgekaatnsnirptdEGSRIGIRVSYAGNLYFYIN 161
Cdd:pfam07177  79 dlRPGYWV--------VALSGSYLQ-----------------------------------EGDRLGFWVTSDGELHFSVN 115

                         170       180       190
                  ....*....|....*....|....*....|...
gi 156356437  162 GKKFGPCATDLPSDSELFVTLDVYGSTKAVKII 194
Cdd:pfam07177 116 GEDQGVALSGVPDSQPLWAVFDLYGQTTQVSIL 148
NEUZ smart00588
domain in neuralized proteins;
3-92 1.04e-25

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 97.00  E-value: 1.04e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156356437     3 RFHPKHGSHITLSPCQTVATRCKS-FANAVVFSNRPLSTSETFVFEIYEQEQGWSGHVRCGVTTHNPNFIKVPP---YLL 78
Cdd:smart00588   4 RFHHRHGSNIRLSDSGRVARRSASdFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASlptNAC 83

                           90
                   ....*....|....
gi 156356437    79 PDLAQMGTTWVFAL 92
Cdd:smart00588  84 PDLVDMSGFWAKAL 97
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 199-235 9.52e-06

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 41.69  E-value: 9.52e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 156356437 199 VPSLLNLCCSKIRILT---LEGSIKSLPIPKLLKQYILSF 235
Cdd:cd03587    2 PRSLQHLCRLAIRRCLgkrRLDLIDKLPLPPRLKDYLLYK 41
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 199-233 1.28e-05

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 41.00  E-value: 1.28e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 156356437  199 VPSLLNLCCSKIRILT---LEGSIKSLPIPKLLKQYIL 233
Cdd:pfam07525   2 PRSLQHLCRLAIRRALgkrRLGAIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 200-235 2.66e-05

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 40.08  E-value: 2.66e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 156356437   200 PSLLNLCCSKIRilTLEGSIKSLPIPKLLKQYILSF 235
Cdd:smart00969   1 RSLQHLCRLAIR--RSLGGIDKLPLPPRLKDYLLYY 34
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 199-235 2.77e-05

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 40.27  E-value: 2.77e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 156356437 199 VPSLLNLCCSKIRILTLEGSIKSLPIPKLLKQYILSF 235
Cdd:cd03717    3 VRSLQHLCRFVIRQCTRRDLIDQLPLPRRLKDYLKEY 39
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 199-235 2.86e-04

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 37.66  E-value: 2.86e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 156356437   199 VPSLLNLCCSKIRILTLEGSIKSLPIPKLLKQYILSF 235
Cdd:smart00253   7 VPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSYY 43
SPRY_SOCS3 cd12876
SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family; The SPRY ...
 142-211 2.97e-04

SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family; The SPRY domain-containing SOCS box protein family (SPSB1-4, also known as SSB-1 to -4) is composed of a central SPRY protein interaction domain and a C-terminal SOCS box. All four SPSB proteins interact with c-Met, the hepatocyte growth factor receptor, but SOCS3 regulates cellular response to a variety of cytokines such as leukemia inhibitory factor (LIF) and interleukin 6. SOCS3, along with SOCS1, are expressed by immune cells and cells of the central nervous system (CNS) and have the potential to impact immune processes within the CNS. In non-small cell lung cancer (NSCLC), SOCS3 is silenced and proline-rich tyrosine kinase 2 (Pyk2) is over-expressed; it has been suggested that SOCS3 could be an effective way to prevent the progression of NSCLC due to its role in regulating Pyk2 expression.


Pssm-ID: 293936  Cd Length: 185  Bit Score: 40.22  E-value: 2.97e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 156356437 142 EGSRIGIRVS-YAGNLYFYINGKKFGPCATDLPSDSELF--VTldvygSTKA---VKIIQCGAVP-SLLNLCCSKIR 211
Cdd:cd12876  114 QGTIIGVHLDmWRGTLTFYKNGKPLGVAFTGLNGVKPLYpmVS-----STAAkseMKLINSRSFPvSLQDRCCAALR 185
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 199-233 6.30e-04

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 36.32  E-value: 6.30e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 156356437 199 VPSLLNLCCSKIRIL---TLEGSIKSLPIPKLLKQYIL 233
Cdd:cd03716    3 PRSLQHLCRLAIRRClgrRRLELIKKLPLPPRLKDYLL 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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