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Conserved domains on  [gi|146091875|ref|XP_001470146|]
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conserved hypothetical protein [Leishmania infantum JPCM5]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK07206 super family cl25872
hypothetical protein; Provisional
228-638 3.13e-37

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PRK07206:

Pssm-ID: 180883 [Multi-domain]  Cd Length: 416  Bit Score: 144.79  E-value: 3.13e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 228 AFGNNPATSrSSRQDKGHAQQVLKEAGLAYVRSYVTTRADEAVA-KVEDGTLLLPVVVKPNSGAGSEFVTLCHTVDDIRV 306
Cdd:PRK07206  95 QYSNDPALS-SARRNKAEMINALAEAGLPAARQINTADWEEAEAwLRENGLIDRPVVIKPLESAGSDGVFICPAKGDWKH 173
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 307 AFSMVKGvRTSQ-GTDAAQLVVEEYIEGPEYVVNTVSYQGVHVVTDVwesWKYPepvvttglTRSAEEAlrtagierqkq 385
Cdd:PRK07206 174 AFNAILG-KANKlGLVNETVLVQEYLIGTEYVVNFVSLDGNHLVTEI---VRYH--------KTSLNSG----------- 230
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 386 rkiSILYDRQTLITnlADLPATHSarrIVEYTLKCLDALGLQNGCGHSEVrldtrktarelrhheqrrlktnnplgkvkd 465
Cdd:PRK07206 231 ---STVYDYDEFLD--YSEPEYQE---LVDYTKQALDALGIKNGPAHAEV------------------------------ 272
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 466 eRLDEGEPILIELNSRMQGdIPRstdvigydqysllvyiseaVNVFGAATAASTALPFRVDSSRPQRVGEIPWPPVPRLY 545
Cdd:PRK07206 273 -MLTADGPRLIEIGARLDG-GLH-------------------PDVARLATGDSQLDATVESLADPDVFRETLREGYRLKA 331
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 546 RARPstgppmattvLFLATKEECILNGV-ALRTLTELGTFQRFTRTIfkpnQPGFVTPlrHTVDLFSSP-TSCVMQGPAA 623
Cdd:PRK07206 332 HVFN----------VFLISPAAGVFSNVeFLEEIQKLPSFKKSHIYV----KEGDYVP--QTVDLFSQPgTVYLVHKDKE 395
                        410
                 ....*....|....*
gi 146091875 624 EVEADCAAIRSMESA 638
Cdd:PRK07206 396 QLWQDYEKIRKMESK 410
PRK02224 super family cl32023
DNA double-strand break repair Rad50 ATPase;
645-757 1.56e-03

DNA double-strand break repair Rad50 ATPase;


The actual alignment was detected with superfamily member PRK02224:

Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 41.95  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 645 KAALFKLTSTIHETERLRENA----RIIDGRLRTMTEAYRHASAQAG--SSTDETADERREkdeqDTENDSCSSQHDLEA 718
Cdd:PRK02224 257 EAEIEDLRETIAETEREREELaeevRDLRERLEELEEERDDLLAEAGldDADAEAVEARRE----ELEDRDEELRDRLEE 332
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 146091875 719 LRSSISSLQSELTWVTNNLAADDRQAQLLRTEfAKALAS 757
Cdd:PRK02224 333 CRVAAQAHNEEAESLREDADDLEERAEELREE-AAELES 370
 
Name Accession Description Interval E-value
PRK07206 PRK07206
hypothetical protein; Provisional
228-638 3.13e-37

hypothetical protein; Provisional


Pssm-ID: 180883 [Multi-domain]  Cd Length: 416  Bit Score: 144.79  E-value: 3.13e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 228 AFGNNPATSrSSRQDKGHAQQVLKEAGLAYVRSYVTTRADEAVA-KVEDGTLLLPVVVKPNSGAGSEFVTLCHTVDDIRV 306
Cdd:PRK07206  95 QYSNDPALS-SARRNKAEMINALAEAGLPAARQINTADWEEAEAwLRENGLIDRPVVIKPLESAGSDGVFICPAKGDWKH 173
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 307 AFSMVKGvRTSQ-GTDAAQLVVEEYIEGPEYVVNTVSYQGVHVVTDVwesWKYPepvvttglTRSAEEAlrtagierqkq 385
Cdd:PRK07206 174 AFNAILG-KANKlGLVNETVLVQEYLIGTEYVVNFVSLDGNHLVTEI---VRYH--------KTSLNSG----------- 230
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 386 rkiSILYDRQTLITnlADLPATHSarrIVEYTLKCLDALGLQNGCGHSEVrldtrktarelrhheqrrlktnnplgkvkd 465
Cdd:PRK07206 231 ---STVYDYDEFLD--YSEPEYQE---LVDYTKQALDALGIKNGPAHAEV------------------------------ 272
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 466 eRLDEGEPILIELNSRMQGdIPRstdvigydqysllvyiseaVNVFGAATAASTALPFRVDSSRPQRVGEIPWPPVPRLY 545
Cdd:PRK07206 273 -MLTADGPRLIEIGARLDG-GLH-------------------PDVARLATGDSQLDATVESLADPDVFRETLREGYRLKA 331
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 546 RARPstgppmattvLFLATKEECILNGV-ALRTLTELGTFQRFTRTIfkpnQPGFVTPlrHTVDLFSSP-TSCVMQGPAA 623
Cdd:PRK07206 332 HVFN----------VFLISPAAGVFSNVeFLEEIQKLPSFKKSHIYV----KEGDYVP--QTVDLFSQPgTVYLVHKDKE 395
                        410
                 ....*....|....*
gi 146091875 624 EVEADCAAIRSMESA 638
Cdd:PRK07206 396 QLWQDYEKIRKMESK 410
AccC COG0439
Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway ...
230-502 1.29e-36

Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440208 [Multi-domain]  Cd Length: 263  Bit Score: 138.47  E-value: 1.29e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 230 GNNPATSRSSRqDKGHAQQVLKEAGLAYVRSYVTTRADEAVAKVEDgtLLLPVVVKPNSGAGSEFVTLCHTVDDIRVAFS 309
Cdd:COG0439   43 GPSPEAIRAMR-DKVLMREALAAAGVPVPGFALVDSPEEALAFAEE--IGYPVVVKPADGAGSRGVRVVRDEEELEAALA 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 310 MVKGVRTSQGTDAaQLVVEEYIEGPEYVVNTVSYQGVHVVTDVWESWKYPEPVVTTGLTrsaeealrtagierqkqrkis 389
Cdd:COG0439  120 EARAEAKAGSPNG-EVLVEEFLEGREYSVEGLVRDGEVVVCSITRKHQKPPYFVELGHE--------------------- 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 390 ilydrqtlitnladLPATHSA---RRIVEYTLKCLDALGLQNGCGHSEVRLDtrktarelrhheqrrlktnnplgkvkde 466
Cdd:COG0439  178 --------------APSPLPEelrAEIGELVARALRALGYRRGAFHTEFLLT---------------------------- 215
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 146091875 467 rlDEGEPILIELNSRMQGD-IPRSTDVI-GYDQYSLLV 502
Cdd:COG0439  216 --PDGEPYLIEINARLGGEhIPPLTELAtGVDLVREQI 251
ATP-grasp_4 pfam13535
ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent ...
280-438 3.78e-06

ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.


Pssm-ID: 316093 [Multi-domain]  Cd Length: 160  Bit Score: 47.66  E-value: 3.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875  280 LPVVVKPNSGAGSEFVTLCHTVDDIRVAFSMVKGVRTSQ-------GTDAAQLVVEEYIEGPEYVVNT-VSYQGVHVVTD 351
Cdd:pfam13535   3 YPCVIKPSVGFFSVGVYKINNREEWKAAFAAIREEIEQWkemypeaVVDGGSFLVEEYIEGEEFAVDAyFDENGEPVILN 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875  352 VWESWKYPEP-VVTTGLTRSAEealrtagIERQKQrkisilydrqtlitnladlpathsaRRIVEYTLKCLDALGLQNGC 430
Cdd:pfam13535  83 ILKHDFASSEdVSDRIYVTSAS-------IIRETQ-------------------------AAFTEFLKRINALLGLKNFP 130

                  ....*...
gi 146091875  431 GHSEVRLD 438
Cdd:pfam13535 131 VHIELRVD 138
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
645-757 1.56e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 41.95  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 645 KAALFKLTSTIHETERLRENA----RIIDGRLRTMTEAYRHASAQAG--SSTDETADERREkdeqDTENDSCSSQHDLEA 718
Cdd:PRK02224 257 EAEIEDLRETIAETEREREELaeevRDLRERLEELEEERDDLLAEAGldDADAEAVEARRE----ELEDRDEELRDRLEE 332
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 146091875 719 LRSSISSLQSELTWVTNNLAADDRQAQLLRTEfAKALAS 757
Cdd:PRK02224 333 CRVAAQAHNEEAESLREDADDLEERAEELREE-AAELES 370
 
Name Accession Description Interval E-value
PRK07206 PRK07206
hypothetical protein; Provisional
228-638 3.13e-37

hypothetical protein; Provisional


Pssm-ID: 180883 [Multi-domain]  Cd Length: 416  Bit Score: 144.79  E-value: 3.13e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 228 AFGNNPATSrSSRQDKGHAQQVLKEAGLAYVRSYVTTRADEAVA-KVEDGTLLLPVVVKPNSGAGSEFVTLCHTVDDIRV 306
Cdd:PRK07206  95 QYSNDPALS-SARRNKAEMINALAEAGLPAARQINTADWEEAEAwLRENGLIDRPVVIKPLESAGSDGVFICPAKGDWKH 173
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 307 AFSMVKGvRTSQ-GTDAAQLVVEEYIEGPEYVVNTVSYQGVHVVTDVwesWKYPepvvttglTRSAEEAlrtagierqkq 385
Cdd:PRK07206 174 AFNAILG-KANKlGLVNETVLVQEYLIGTEYVVNFVSLDGNHLVTEI---VRYH--------KTSLNSG----------- 230
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 386 rkiSILYDRQTLITnlADLPATHSarrIVEYTLKCLDALGLQNGCGHSEVrldtrktarelrhheqrrlktnnplgkvkd 465
Cdd:PRK07206 231 ---STVYDYDEFLD--YSEPEYQE---LVDYTKQALDALGIKNGPAHAEV------------------------------ 272
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 466 eRLDEGEPILIELNSRMQGdIPRstdvigydqysllvyiseaVNVFGAATAASTALPFRVDSSRPQRVGEIPWPPVPRLY 545
Cdd:PRK07206 273 -MLTADGPRLIEIGARLDG-GLH-------------------PDVARLATGDSQLDATVESLADPDVFRETLREGYRLKA 331
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 546 RARPstgppmattvLFLATKEECILNGV-ALRTLTELGTFQRFTRTIfkpnQPGFVTPlrHTVDLFSSP-TSCVMQGPAA 623
Cdd:PRK07206 332 HVFN----------VFLISPAAGVFSNVeFLEEIQKLPSFKKSHIYV----KEGDYVP--QTVDLFSQPgTVYLVHKDKE 395
                        410
                 ....*....|....*
gi 146091875 624 EVEADCAAIRSMESA 638
Cdd:PRK07206 396 QLWQDYEKIRKMESK 410
AccC COG0439
Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway ...
230-502 1.29e-36

Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440208 [Multi-domain]  Cd Length: 263  Bit Score: 138.47  E-value: 1.29e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 230 GNNPATSRSSRqDKGHAQQVLKEAGLAYVRSYVTTRADEAVAKVEDgtLLLPVVVKPNSGAGSEFVTLCHTVDDIRVAFS 309
Cdd:COG0439   43 GPSPEAIRAMR-DKVLMREALAAAGVPVPGFALVDSPEEALAFAEE--IGYPVVVKPADGAGSRGVRVVRDEEELEAALA 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 310 MVKGVRTSQGTDAaQLVVEEYIEGPEYVVNTVSYQGVHVVTDVWESWKYPEPVVTTGLTrsaeealrtagierqkqrkis 389
Cdd:COG0439  120 EARAEAKAGSPNG-EVLVEEFLEGREYSVEGLVRDGEVVVCSITRKHQKPPYFVELGHE--------------------- 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 390 ilydrqtlitnladLPATHSA---RRIVEYTLKCLDALGLQNGCGHSEVRLDtrktarelrhheqrrlktnnplgkvkde 466
Cdd:COG0439  178 --------------APSPLPEelrAEIGELVARALRALGYRRGAFHTEFLLT---------------------------- 215
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 146091875 467 rlDEGEPILIELNSRMQGD-IPRSTDVI-GYDQYSLLV 502
Cdd:COG0439  216 --PDGEPYLIEINARLGGEhIPPLTELAtGVDLVREQI 251
PRK02186 PRK02186
argininosuccinate lyase; Provisional
205-553 4.78e-15

argininosuccinate lyase; Provisional


Pssm-ID: 235010 [Multi-domain]  Cd Length: 887  Bit Score: 79.51  E-value: 4.78e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 205 EDVVEALDGLEA---------EVPTCVYTRVNAFGNNPATSRSSRqDKGHAQQVLKEAGLAYVRSYVTTrADEAVAKVED 275
Cdd:PRK02186  62 HRFVSSLDGVAGimssseyfiEVASEVARRLGLPAANTEAIRTCR-DKKRLARTLRDHGIDVPRTHALA-LRAVALDALD 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 276 GtLLLPVVVKPNSGAGSEFVTLCHTVDDIRVAFSMVKGVRTSqgtdaaQLVVEEYIEGPEYVVNTVSYQGVHVVTDVWES 355
Cdd:PRK02186 140 G-LTYPVVVKPRMGSGSVGVRLCASVAEAAAHCAALRRAGTR------AALVQAYVEGDEYSVETLTVARGHQVLGITRK 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 356 WKYPEP-VVTTGltrsaeealrtagierqkqrkisilydrqtlitnlADLPATHSA---RRIVEYTLKCLDALGLQNGCG 431
Cdd:PRK02186 213 HLGPPPhFVEIG-----------------------------------HDFPAPLSApqrERIVRTVLRALDAVGYAFGPA 257
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 432 HSEVrldtrktarelrhheqrrlktnnplgkvkdeRLDEGEPILIELNSRMQGD-IPRSTD-VIGYDQYSLLVYISEAVN 509
Cdd:PRK02186 258 HTEL-------------------------------RVRGDTVVIIEINPRLAGGmIPVLLEeAFGVDLLDHVIDLHLGVA 306
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 146091875 510 VFGAATAA-STALPFRVdSSRPQRVGEIPWPPVPRLYRARPSTGP 553
Cdd:PRK02186 307 AFADPTAKrYGAIRFVL-PARSGVLRGLLFLPDDIAARPELRFHP 350
DdlA COG1181
D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, ...
173-342 1.95e-10

D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, General function prediction only]; D-alanine-D-alanine ligase or related ATP-grasp enzyme is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440794 [Multi-domain]  Cd Length: 303  Bit Score: 62.82  E-value: 1.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 173 ASGDGVVPALD--YVNARLCGESVQSLAQR---MGFD-----------ED-VVEALdgLE-AEVPtcvYTrvnafGNNPA 234
Cdd:COG1181   19 KSGRAVAAALDkaGYDVVPIGIDVEDLPAAlkeLKPDvvfpalhgrggEDgTIQGL--LElLGIP---YT-----GSGVL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 235 TSRSSRqDKGHAQQVLKEAGLAYVRSYVTTRADEAVAKVEDGTLLLPVVVKPNSGaGSEF-VTLCHTVDDIRVAFSmvkg 313
Cdd:COG1181   89 ASALAM-DKALTKRVLAAAGLPTPPYVVLRRGELADLEAIEEELGLPLFVKPARE-GSSVgVSKVKNAEELAAALE---- 162
                        170       180       190
                 ....*....|....*....|....*....|...
gi 146091875 314 vrtsqgtDAAQ----LVVEEYIEGPEYvvnTVS 342
Cdd:COG1181  163 -------EAFKyddkVLVEEFIDGREV---TVG 185
ddl PRK01372
D-alanine--D-alanine ligase; Reviewed
242-338 6.21e-10

D-alanine--D-alanine ligase; Reviewed


Pssm-ID: 234948 [Multi-domain]  Cd Length: 304  Bit Score: 61.28  E-value: 6.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 242 DKGHAQQVLKEAGLAYVRSYVTTRADEAVAKVEDgtLLLPVVVKPNSGaGSEF-VTLCHTVDDIRVAFSmvkgvrtsqgt 320
Cdd:PRK01372  98 DKLRTKLVWQAAGLPTPPWIVLTREEDLLAAIDK--LGLPLVVKPARE-GSSVgVSKVKEEDELQAALE----------- 163
                         90       100
                 ....*....|....*....|..
gi 146091875 321 DAA----QLVVEEYIEGPEYVV 338
Cdd:PRK01372 164 LAFkyddEVLVEKYIKGRELTV 185
PRK12767 PRK12767
carbamoyl phosphate synthase-like protein; Provisional
241-342 2.13e-09

carbamoyl phosphate synthase-like protein; Provisional


Pssm-ID: 237195 [Multi-domain]  Cd Length: 326  Bit Score: 59.90  E-value: 2.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 241 QDKGHAQQVLKEAGLAYVRSYVTTRADEAVAKVEDGTLLLPVVVKPNSGAGSEFVTLCHTVDDIRVAFSMVKGvrtsqgt 320
Cdd:PRK12767 110 NDKWLTYEFLKENGIPTPKSYLPESLEDFKAALAKGELQFPLFVKPRDGSASIGVFKVNDKEELEFLLEYVPN------- 182
                         90       100
                 ....*....|....*....|..
gi 146091875 321 daaqLVVEEYIEGPEYVVNTVS 342
Cdd:PRK12767 183 ----LIIQEFIEGQEYTVDVLC 200
LysX COG0189
Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport ...
231-339 1.55e-08

Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport and metabolism, Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis, Secondary metabolites biosynthesis, transport and catabolism]; Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 439959 [Multi-domain]  Cd Length: 289  Bit Score: 56.87  E-value: 1.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 231 NNPATSRSSRqDKGHAQQVLKEAGLAYVRSYVTTRADEAVAKVEDgtLLLPVVVKPNSGAGSEFVTLCHTVDDIRVAfsm 310
Cdd:COG0189   86 NDPEAIRRAR-DKLFTLQLLARAGIPVPPTLVTRDPDDLRAFLEE--LGGPVVLKPLDGSGGRGVFLVEDEDALESI--- 159
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 146091875 311 vkgVRTSQGTDAAQLVVEEYIEGPE------YVVN 339
Cdd:COG0189  160 ---LEALTELGSEPVLVQEFIPEEDgrdirvLVVG 191
ATP-grasp_4 pfam13535
ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent ...
280-438 3.78e-06

ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.


Pssm-ID: 316093 [Multi-domain]  Cd Length: 160  Bit Score: 47.66  E-value: 3.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875  280 LPVVVKPNSGAGSEFVTLCHTVDDIRVAFSMVKGVRTSQ-------GTDAAQLVVEEYIEGPEYVVNT-VSYQGVHVVTD 351
Cdd:pfam13535   3 YPCVIKPSVGFFSVGVYKINNREEWKAAFAAIREEIEQWkemypeaVVDGGSFLVEEYIEGEEFAVDAyFDENGEPVILN 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875  352 VWESWKYPEP-VVTTGLTRSAEealrtagIERQKQrkisilydrqtlitnladlpathsaRRIVEYTLKCLDALGLQNGC 430
Cdd:pfam13535  83 ILKHDFASSEdVSDRIYVTSAS-------IIRETQ-------------------------AAFTEFLKRINALLGLKNFP 130

                  ....*...
gi 146091875  431 GHSEVRLD 438
Cdd:pfam13535 131 VHIELRVD 138
PRK14016 PRK14016
cyanophycin synthetase; Provisional
241-339 4.12e-05

cyanophycin synthetase; Provisional


Pssm-ID: 237586 [Multi-domain]  Cd Length: 727  Bit Score: 47.07  E-value: 4.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 241 QDKGHAQQVLKEAGLAYVRSYVTTRADEAVAKVEDgtLLLPVVVKP---NSGAGsefVTL-CHTVDDIRVAFSmvkgVRT 316
Cdd:PRK14016 213 CDKELTKRLLAAAGVPVPEGRVVTSAEDAWEAAEE--IGYPVVVKPldgNHGRG---VTVnITTREEIEAAYA----VAS 283
                         90       100
                 ....*....|....*....|....*.
gi 146091875 317 SQGTDAaqlVVEEYIEGPEY---VVN 339
Cdd:PRK14016 284 KESSDV---IVERYIPGKDHrllVVG 306
ATP-grasp_3 pfam02655
ATP-grasp domain; No functional information or experimental verification of function is known ...
242-342 1.83e-04

ATP-grasp domain; No functional information or experimental verification of function is known in this family. This family appears to be an ATP-grasp domain (Pers. obs. A Bateman).


Pssm-ID: 396979 [Multi-domain]  Cd Length: 160  Bit Score: 42.76  E-value: 1.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875  242 DKGHAQQVLKEAGlayVRSYVTTRADEAVAKVEdgtlllPVVVKPNSGAGSEFVTLchtVDDIRVAFSMVKGVrtsqgtd 321
Cdd:pfam02655   3 DKLKTYKALKNAG---VPTPETLQAEELLREEK------KYVVKPRDGCGGEGVRK---VENGREDEAFIENV------- 63
                          90       100
                  ....*....|....*....|.
gi 146091875  322 aaqlVVEEYIEGPEYVVNTVS 342
Cdd:pfam02655  64 ----LVQEFIEGEPLSVSLLS 80
ddl PRK01966
D-alanine--D-alanine ligase;
242-336 4.58e-04

D-alanine--D-alanine ligase;


Pssm-ID: 234993 [Multi-domain]  Cd Length: 333  Bit Score: 43.19  E-value: 4.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 242 DKGHAQQVLKEAGLAYVRSYVTTRADEAVAKVED--GTLLLPVVVKPNSgAGSEF-VTLCHTVDDIRVAFsmvkgvrtsq 318
Cdd:PRK01966 123 DKILTKRLLAAAGIPVAPYVVLTRGDWEEASLAEieAKLGLPVFVKPAN-LGSSVgISKVKNEEELAAAL---------- 191
                         90       100
                 ....*....|....*....|...
gi 146091875 319 gtDAA-----QLVVEEYIEGPEY 336
Cdd:PRK01966 192 --DLAfeydrKVLVEQGIKGREI 212
PurD COG0151
Phosphoribosylamine-glycine ligase [Nucleotide transport and metabolism]; ...
243-351 8.11e-04

Phosphoribosylamine-glycine ligase [Nucleotide transport and metabolism]; Phosphoribosylamine-glycine ligase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439921 [Multi-domain]  Cd Length: 422  Bit Score: 42.69  E-value: 8.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 243 KGHAQQVLKEAG---LAYVrsyVTTRADEAVAKVEdgTLLLPVVVKPN---SGAGsefVTLCHTVDDIRVAFS--MVKGV 314
Cdd:COG0151  103 KAFAKEFMARYGiptAAYR---VFTDLEEALAYLE--EQGAPIVVKADglaAGKG---VVVAETLEEALAAVDdmLADGK 174
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 146091875 315 RTSQGtdaAQLVVEEYIEGPEyvvntVSyqgVHVVTD 351
Cdd:COG0151  175 FGDAG---ARVVIEEFLEGEE-----AS---LFALTD 200
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
645-757 1.56e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 41.95  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 645 KAALFKLTSTIHETERLRENA----RIIDGRLRTMTEAYRHASAQAG--SSTDETADERREkdeqDTENDSCSSQHDLEA 718
Cdd:PRK02224 257 EAEIEDLRETIAETEREREELaeevRDLRERLEELEEERDDLLAEAGldDADAEAVEARRE----ELEDRDEELRDRLEE 332
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 146091875 719 LRSSISSLQSELTWVTNNLAADDRQAQLLRTEfAKALAS 757
Cdd:PRK02224 333 CRVAAQAHNEEAESLREDADDLEERAEELREE-AAELES 370
COG3919 COG3919
Predicted ATP-dependent carboligase, ATP-grasp superfamily [General function prediction only];
241-340 2.04e-03

Predicted ATP-dependent carboligase, ATP-grasp superfamily [General function prediction only];


Pssm-ID: 443124 [Multi-domain]  Cd Length: 382  Bit Score: 41.07  E-value: 2.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875 241 QDKGHAQQVLKEAGLAYVRSYVTTRADEAVAKVEDgtLLLPVVVKPNSGAGSEFVTLC-----HTVDDIRVAFSMVKGVR 315
Cdd:COG3919  116 LDKERFYELAEELGVPVPKTVVLDSADDLDALAED--LGFPVVVKPADSVGYDELSFPgkkkvFYVDDREELLALLRRIA 193
                         90       100
                 ....*....|....*....|....*...
gi 146091875 316 TSQGTdaaqLVVEEYIEGP---EYVVNT 340
Cdd:COG3919  194 AAGYE----LIVQEYIPGDdgeMRGLTA 217
Dala_Dala_lig_C pfam07478
D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the ...
249-335 5.50e-03

D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF).


Pssm-ID: 429483 [Multi-domain]  Cd Length: 204  Bit Score: 38.84  E-value: 5.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146091875  249 VLKEAGLAYVRSYVTTRAD------EAVAKVEdGTLLLPVVVKPnSGAGSEF-VTLCHTVDDIRVAFSmvkgvrtsqgtD 321
Cdd:pfam07478   1 LLKAAGLPVVPFVTFTRADwklnpkEWCAQVE-EALGYPVFVKP-ARLGSSVgVSKVESREELQAAIE-----------E 67
                          90
                  ....*....|....*...
gi 146091875  322 AAQ----LVVEEYIEGPE 335
Cdd:pfam07478  68 AFQydekVLVEEGIEGRE 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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