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Conserved domains on  [gi|145537728|ref|XP_001454575|]
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uncharacterized protein GSPATT00020831001 [Paramecium tetraurelia]

Protein Classification

dynein light chain( domain architecture ID 16901482)

dynein light chain is a non-catalytic accessory component of the cytoplasmic dynein complex and is thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function

CATH:  3.30.740.10
Gene Ontology:  GO:0045505|GO:0007017|GO:0030286
PubMed:  17546040|19805907|36861883
SCOP:  3000821

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DLC-like_DYNLL1_DYNLL2 cd21452
dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) ...
 7-90 3.96e-52

dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family; The cytoplasmic dynein light chain 1 (DYNLL1) family includes DYNLL1 and DYNLL2. DYNLL1, also called protein inhibitor of neuronal nitric oxide synthase (PIN), or 8 kDa dynein light chain (DLC8), or dynein light chain LC8-type 1 (DLC1), acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. It may play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Both DYNLL1 and DYNLL2 (also called 8 kDa dynein light chain b, or DLC8b, or dynein light chain LC8-type 2, or DLC2) are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. The model corresponds to the dynein light chain (DLC)-like domain of DYNLL1 and DYNLL2.


:

Pssm-ID: 412000  Cd Length: 84  Bit Score: 157.65  E-value: 3.96e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145537728  7 QPVIKQIDMSDEMQREVIEVSRQAIDKSSTDQQIASYIKDELRAKYHGTWHCIVGRNFGSYVTHETKHYIYFYIGQLAIM 86
Cdd:cd21452   1 KAVIKNADMPEEMQQDAIELATQALEKYNIEKDIAAYIKKEFDKKYGPTWHCIVGRNFGSYVTHETKHFIYFYIGQVAIL 80


                ....
gi 145537728 87 LFKT 90
Cdd:cd21452  81 LFKS 84
 
Name Accession Description Interval E-value
DLC-like_DYNLL1_DYNLL2 cd21452
dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) ...
 7-90 3.96e-52

dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family; The cytoplasmic dynein light chain 1 (DYNLL1) family includes DYNLL1 and DYNLL2. DYNLL1, also called protein inhibitor of neuronal nitric oxide synthase (PIN), or 8 kDa dynein light chain (DLC8), or dynein light chain LC8-type 1 (DLC1), acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. It may play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Both DYNLL1 and DYNLL2 (also called 8 kDa dynein light chain b, or DLC8b, or dynein light chain LC8-type 2, or DLC2) are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. The model corresponds to the dynein light chain (DLC)-like domain of DYNLL1 and DYNLL2.


Pssm-ID: 412000  Cd Length: 84  Bit Score: 157.65  E-value: 3.96e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145537728  7 QPVIKQIDMSDEMQREVIEVSRQAIDKSSTDQQIASYIKDELRAKYHGTWHCIVGRNFGSYVTHETKHYIYFYIGQLAIM 86
Cdd:cd21452   1 KAVIKNADMPEEMQQDAIELATQALEKYNIEKDIAAYIKKEFDKKYGPTWHCIVGRNFGSYVTHETKHFIYFYIGQVAIL 80


                ....
gi 145537728 87 LFKT 90
Cdd:cd21452  81 LFKS 84
Dynein_light pfam01221
Dynein light chain type 1;
7-89 1.36e-43

Dynein light chain type 1;


Pssm-ID: 460119  Cd Length: 83  Bit Score: 135.74  E-value: 1.36e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145537728   7 QPVIKQIDMSDEMQREVIEVSRQAIDKSSTDQQIASYIKDELRAKYHGTWHCIVGRNFGSYVTHETKHYIYFYIGQLAIM 86
Cdd:pfam01221  1 KAVIKASDMPEEMQQEAIEIAQEALEKYNIEKDIAAYIKKEFDKKYGPTWHCIVGKNFGSYVTHETGHFIYFYIGNLAIL 80


                 ...
gi 145537728  87 LFK 89
Cdd:pfam01221 81 LFK 83
PTZ00059 PTZ00059
dynein light chain; Provisional
 9-91 9.99e-41

dynein light chain; Provisional


Pssm-ID: 185421  Cd Length: 90  Bit Score: 129.16  E-value: 9.99e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145537728  9 VIKQIDMSDEMQREVIEVSRQAIDKSSTDQQIASYIKDELRAKYHGTWHCIVGRNFGSYVTHETKHYIYFYIGQLAIMLF 88
Cdd:PTZ00059  8 VVKNADMSEDMQQDAIDCANQALEKFNIEKDIAAYIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLF 87


                ...
gi 145537728 89 KTG 91
Cdd:PTZ00059 88 KSG 90
 
Name Accession Description Interval E-value
DLC-like_DYNLL1_DYNLL2 cd21452
dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) ...
 7-90 3.96e-52

dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family; The cytoplasmic dynein light chain 1 (DYNLL1) family includes DYNLL1 and DYNLL2. DYNLL1, also called protein inhibitor of neuronal nitric oxide synthase (PIN), or 8 kDa dynein light chain (DLC8), or dynein light chain LC8-type 1 (DLC1), acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. It may play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Both DYNLL1 and DYNLL2 (also called 8 kDa dynein light chain b, or DLC8b, or dynein light chain LC8-type 2, or DLC2) are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. The model corresponds to the dynein light chain (DLC)-like domain of DYNLL1 and DYNLL2.


Pssm-ID: 412000  Cd Length: 84  Bit Score: 157.65  E-value: 3.96e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145537728  7 QPVIKQIDMSDEMQREVIEVSRQAIDKSSTDQQIASYIKDELRAKYHGTWHCIVGRNFGSYVTHETKHYIYFYIGQLAIM 86
Cdd:cd21452   1 KAVIKNADMPEEMQQDAIELATQALEKYNIEKDIAAYIKKEFDKKYGPTWHCIVGRNFGSYVTHETKHFIYFYIGQVAIL 80


                ....
gi 145537728 87 LFKT 90
Cdd:cd21452  81 LFKS 84
Dynein_light pfam01221
Dynein light chain type 1;
7-89 1.36e-43

Dynein light chain type 1;


Pssm-ID: 460119  Cd Length: 83  Bit Score: 135.74  E-value: 1.36e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145537728   7 QPVIKQIDMSDEMQREVIEVSRQAIDKSSTDQQIASYIKDELRAKYHGTWHCIVGRNFGSYVTHETKHYIYFYIGQLAIM 86
Cdd:pfam01221  1 KAVIKASDMPEEMQQEAIEIAQEALEKYNIEKDIAAYIKKEFDKKYGPTWHCIVGKNFGSYVTHETGHFIYFYIGNLAIL 80


                 ...
gi 145537728  87 LFK 89
Cdd:pfam01221 81 LFK 83
PTZ00059 PTZ00059
dynein light chain; Provisional
 9-91 9.99e-41

dynein light chain; Provisional


Pssm-ID: 185421  Cd Length: 90  Bit Score: 129.16  E-value: 9.99e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145537728  9 VIKQIDMSDEMQREVIEVSRQAIDKSSTDQQIASYIKDELRAKYHGTWHCIVGRNFGSYVTHETKHYIYFYIGQLAIMLF 88
Cdd:PTZ00059  8 VVKNADMSEDMQQDAIDCANQALEKFNIEKDIAAYIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLF 87


                ...
gi 145537728 89 KTG 91
Cdd:PTZ00059 88 KSG 90
DLC-like_DYNLL1-like cd21450
dynein light chain (DLC)-like domain found in cytoplasmic dynein light chain 1 (DYNLL1), ...
 22-89 2.50e-30

dynein light chain (DLC)-like domain found in cytoplasmic dynein light chain 1 (DYNLL1), axonemal dynein light chain 4 (DNAL4), tegumental-allergen-like proteins (TALs) and similar proteins; The family includes cytoplasmic dynein light chain 1 (DYNLL1), DYNLL2, axonemal dynein light chain 4 (DNAL4), and tegumental-allergen-like proteins (TALs). DYNLL1, also called protein inhibitor of neuronal nitric oxide synthase (PIN), or 8 kDa dynein light chain (DLC8), or dynein light chain LC8-type 1 (DLC1), is one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. It acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. It may play a role in changing or maintaining the spatial distribution of cytoskeletal structures. DYNLL2, also called cytoplasmic dynein light chain 2, or 8 kDa dynein light chain b (DLC8b), or dynein light chain LC8-type 2 (DLC2), is one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. DNAL4 is a force generating protein of respiratory cilia. It produces force towards the minus ends of microtubules. TALs, also called tegument antigens, are characterized by two N-terminal EF-hand motifs and a C-terminal region resembling a dynein light chain (DLC)-like domain. They were mainly found in parasitic platyhelminth species. TALs are strongly associated with the tegument, a syncytial structure that forms the outer layer of the organism. They may be involved in the transport of vesicles within the tegumental cytoplasm, probably within dynein motor complexes.


Pssm-ID: 411998  Cd Length: 68  Bit Score: 101.84  E-value: 2.50e-30
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145537728 22 EVIEVSRQAIDKSSTDQQIASYIKDELRAKYHGTWHCIVGRNFGSYVTHETKHYIYFYIGQLAIMLFK 89
Cdd:cd21450   1 DAVEIAAEALEKYKSEKDIAKYIKKELDKKYGPTWHCIVGKSFGSSVTHEPGTFIYFKVGDLAVLLFK 68
DLC-like_DNAL4 cd21453
dynein light chain (DLC)-like domain found in axonemal dynein light chain 4 (DNAL4) and ...
 9-89 2.24e-24

dynein light chain (DLC)-like domain found in axonemal dynein light chain 4 (DNAL4) and similar proteins; Axonemal dynein light chain 4 (DNAL4) is a force generating protein of respiratory cilia. It produces force towards the minus ends of microtubules. The model corresponds to the dynein light chain (DLC)-like domain of DNAL4.


Pssm-ID: 412001  Cd Length: 83  Bit Score: 87.19  E-value: 2.24e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145537728  9 VIKQIDMSDEMQREVIEVSRQAIDKSSTD-QQIASYIKDELRAKYHGTWHCIVGRNFGSYVTHETKHYIY-FYIGQLAIM 86
Cdd:cd21453   1 LVKHSDMPEEMRTEAVEICVTACEKFSNNnELAAKMIKETLDKKFGPSWHVVVGEGFGFEITYEVKNLLYmFFGGNLAIL 80


                ...
gi 145537728 87 LFK 89
Cdd:cd21453  81 VWK 83
PLN03058 PLN03058
dynein light chain type 1 family protein; Provisional
 4-90 5.16e-18

dynein light chain type 1 family protein; Provisional


Pssm-ID: 166697 [Multi-domain]  Cd Length: 128  Bit Score: 72.72  E-value: 5.16e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145537728   4 DKLQPVIKQIDMSDEMQREVIEVSRQAIDKSS---TDQQIASYIKDELRAKYHGTWHCIVGRNFGSYVTHETKHYIYFYI 80
Cdd:PLN03058  32 DELNVRVRASDMPLVLQNRAFSCARDILDAMPgklDSKRLALALKKEFDSAYGPAWHCIVGTSFGSYVTHSTGGFLYFSI 111

                         90
                 ....*....|
gi 145537728  81 GQLAIMLFKT 90
Cdd:PLN03058 112 DKVYILLFKT 121
DLC-like_TAL cd21454
dynein light chain (DLC)-like domain found in the family of tegumental-allergen-like proteins ...
 14-90 1.15e-11

dynein light chain (DLC)-like domain found in the family of tegumental-allergen-like proteins (TALs); Tegumental-allergen-like proteins (TALs), also called tegument antigens, are characterized by two N-terminal EF-hand motifs and a C-terminal region resembling a dynein light chain (DLC)-like domain. They were mainly found in parasitic platyhelminth species. TALs are strongly associated with the tegument, a syncytial structure that forms the outer layer of the organism. They may be involved in the transport of vesicles within the tegumental cytoplasm, probably within dynein motor complexes. The model corresponds to the dynein light chain (DLC)-like domain of TAL.


Pssm-ID: 412002  Cd Length: 87  Bit Score: 55.28  E-value: 1.15e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145537728 14 DMSDEMQREVIEVSRQAIDKSSTD--QQIASYIKDELRAKYHGTWHCIVGRN-FGSYVTHETKHYIYFYIGQLAIMLFKT 90
Cdd:cd21454   8 DMPLEMQVKILEKVRELLRESKKKnlKELVQELKRYLDERYGRLWHVVIVRGsYWASYSHEPGTSFHFRLGDYIYLVWRT 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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