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Conserved domains on  [gi|145349386|ref|XP_001419116|]
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predicted protein [Ostreococcus lucimarinus CCE9901]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12822048)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-358 2.70e-29

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 120.02  E-value: 2.70e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386   2 AALVRRQRALEDDADRARAAFPTAFGRGGGAGATARDVVDDGARATAALGARDDDDDDGGGGGGGGGGEADRGSGEEEYE 81
Cdd:COG2319   24 ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVR 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386  82 EEDAIPRAAEAVMEGFKKPATCCAVDRSGARMAAGSSDGVVRLYDFngmkRDLQPFRSIAPREGyPIHAVDWSPTGDMFv 161
Cdd:COG2319  104 LWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL----ATGKLLRTLTGHSG-AVTSVAFSPDGKLL- 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 162 aASGSWQPTVHdrdgveLGEFDKGdmyiRDLRNTKGHVAATTDVKWNPlDKETICTAGEDGALRLWDVtylgdARGSQKA 241
Cdd:COG2319  178 -ASGSDDGTVR------LWDLATG----KLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDL-----ATGKLLR 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 242 VLKPQQvkpgrVQVTSCAYSHDGDLIAGGITDGSVQIFSSKGSHHLFKGAHPAGeEVTSLSFGRDGRTLLSRCEDGTLNV 321
Cdd:COG2319  241 TLTGHS-----GSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRL 314

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 145349386 322 WDLRNvKAPLKRFEDlpTRHSETTVGWSPNDVYFFTG 358
Cdd:COG2319  315 WDLAT-GKLLRTLTG--HTGAVRSVAFSPDGKTLASG 348
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 284-435 2.88e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 2.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 284 SHHLFKGaHPAGeeVTSLSFGRDGRTLLSRCEDGTLNVWDLRNvKAPLKRFEDlptrHSE--TTVGWSPNDVYFFTGvda 361
Cdd:cd00200    1 LRRTLKG-HTGG--VTCVAFSPDGKLLATGSGDGTIKVWDLET-GELLRTLKG----HTGpvRDVAASADGTYLASG--- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 362 erdsrGGNtqGGLCFFDREKLEMVHRVST---PTNCIAatWHPrLNQIFVGCGDAKggELRV----LYDPKKSMGGITQA 434
Cdd:cd00200   70 -----SSD--KTIRLWDLETGECVRTLTGhtsYVSSVA--FSP-DGRILSSSSRDK--TIKVwdveTGKCLTTLRGHTDW 137


                 .
gi 145349386 435 V 435
Cdd:cd00200  138 V 138
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-358 2.70e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 120.02  E-value: 2.70e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386   2 AALVRRQRALEDDADRARAAFPTAFGRGGGAGATARDVVDDGARATAALGARDDDDDDGGGGGGGGGGEADRGSGEEEYE 81
Cdd:COG2319   24 ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVR 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386  82 EEDAIPRAAEAVMEGFKKPATCCAVDRSGARMAAGSSDGVVRLYDFngmkRDLQPFRSIAPREGyPIHAVDWSPTGDMFv 161
Cdd:COG2319  104 LWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL----ATGKLLRTLTGHSG-AVTSVAFSPDGKLL- 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 162 aASGSWQPTVHdrdgveLGEFDKGdmyiRDLRNTKGHVAATTDVKWNPlDKETICTAGEDGALRLWDVtylgdARGSQKA 241
Cdd:COG2319  178 -ASGSDDGTVR------LWDLATG----KLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDL-----ATGKLLR 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 242 VLKPQQvkpgrVQVTSCAYSHDGDLIAGGITDGSVQIFSSKGSHHLFKGAHPAGeEVTSLSFGRDGRTLLSRCEDGTLNV 321
Cdd:COG2319  241 TLTGHS-----GSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRL 314

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 145349386 322 WDLRNvKAPLKRFEDlpTRHSETTVGWSPNDVYFFTG 358
Cdd:COG2319  315 WDLAT-GKLLRTLTG--HTGAVRSVAFSPDGKTLASG 348
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 92-412 5.30e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.58  E-value: 5.30e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386  92 AVMEGFKKPATCCAVDRSGARMAAGSSDGVVRLYDFNGMkrdlQPFRSIAPREGyPIHAVDWSPTGDMFVAASGSWQPTV 171
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG----ELLRTLKGHTG-PVRDVAASADGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 172 HD-RDGVELGEFdkgdmyirdlrntKGHVAATTDVKWNPlDKETICTAGEDGALRLWDVtylgdARGSQKAVLKPQQvkp 250
Cdd:cd00200   78 WDlETGECVRTL-------------TGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDV-----ETGKCLTTLRGHT--- 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 251 grVQVTSCAYSHDGDLIAGGITDGSVQIFSSKGSH--HLFKGaHPagEEVTSLSFGRDGRTLLSRCEDGTLNVWDLRNvK 328
Cdd:cd00200  136 --DWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKcvATLTG-HT--GEVNSVAFSPDGEKLLSSSSDGTIKLWDLST-G 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 329 APLKRFedlpTRHSE--TTVGWSPNDVYFFtgvdaerdsrGGNTQGGLCFFDREKLEMVHRVSTPTN-CIAATWHPRLNQ 405
Cdd:cd00200  210 KCLGTL----RGHENgvNSVAFSPDGYLLA----------SGSEDGTIRVWDLRTGECVQTLSGHTNsVTSLAWSPDGKR 275


                 ....*..
gi 145349386 406 IFVGCGD 412
Cdd:cd00200  276 LASGSAD 282
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 207-331 1.09e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 1.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 207 WNPLDKETICTAGEDGALRLWDVtylgdARGSQKAVLKPQQVKPGRVQVTSCayshDGDLIAGGITDGSVQIFSSKGSHH 286
Cdd:PLN00181 540 WNSYIKSQVASSNFEGVVQVWDV-----ARSQLVTEMKEHEKRVWSIDYSSA----DPTLLASGSDDGSVKLWSINQGVS 610

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 145349386 287 LfkGAHPAGEEVTSLSFGRD-GRTLLSRCEDGTLNVWDLRNVKAPL 331
Cdd:PLN00181 611 I--GTIKTKANICCVQFPSEsGRSLAFGSADHKVYYYDLRNPKLPL 654
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 265-351 1.80e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 40.72  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386  265 DLIAGGITDGSVQIFSSKGsHHLFKGAHPA-GEEVTSLSFGRDGRTLLSRCEDGTLNVWDLRNVKaPLKRFEdlPTRHSE 343
Cdd:pfam12894   8 DLIALATEDGELLLHRLNW-QRVWTLSPDKeDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGK-IVHHFS--AGSDLI 83


                  ....*...
gi 145349386  344 TTVGWSPN 351
Cdd:pfam12894  84 TCLGWGEN 91
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 284-435 2.88e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 2.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 284 SHHLFKGaHPAGeeVTSLSFGRDGRTLLSRCEDGTLNVWDLRNvKAPLKRFEDlptrHSE--TTVGWSPNDVYFFTGvda 361
Cdd:cd00200    1 LRRTLKG-HTGG--VTCVAFSPDGKLLATGSGDGTIKVWDLET-GELLRTLKG----HTGpvRDVAASADGTYLASG--- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 362 erdsrGGNtqGGLCFFDREKLEMVHRVST---PTNCIAatWHPrLNQIFVGCGDAKggELRV----LYDPKKSMGGITQA 434
Cdd:cd00200   70 -----SSD--KTIRLWDLETGECVRTLTGhtsYVSSVA--FSP-DGRILSSSSRDK--TIKVwdveTGKCLTTLRGHTDW 137


                 .
gi 145349386 435 V 435
Cdd:cd00200  138 V 138
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 196-228 4.80e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 4.80e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 145349386   196 KGHVAATTDVKWNPlDKETICTAGEDGALRLWD 228
Cdd:smart00320   9 KGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-358 2.70e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 120.02  E-value: 2.70e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386   2 AALVRRQRALEDDADRARAAFPTAFGRGGGAGATARDVVDDGARATAALGARDDDDDDGGGGGGGGGGEADRGSGEEEYE 81
Cdd:COG2319   24 ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVR 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386  82 EEDAIPRAAEAVMEGFKKPATCCAVDRSGARMAAGSSDGVVRLYDFngmkRDLQPFRSIAPREGyPIHAVDWSPTGDMFv 161
Cdd:COG2319  104 LWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL----ATGKLLRTLTGHSG-AVTSVAFSPDGKLL- 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 162 aASGSWQPTVHdrdgveLGEFDKGdmyiRDLRNTKGHVAATTDVKWNPlDKETICTAGEDGALRLWDVtylgdARGSQKA 241
Cdd:COG2319  178 -ASGSDDGTVR------LWDLATG----KLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDL-----ATGKLLR 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 242 VLKPQQvkpgrVQVTSCAYSHDGDLIAGGITDGSVQIFSSKGSHHLFKGAHPAGeEVTSLSFGRDGRTLLSRCEDGTLNV 321
Cdd:COG2319  241 TLTGHS-----GSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRL 314

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 145349386 322 WDLRNvKAPLKRFEDlpTRHSETTVGWSPNDVYFFTG 358
Cdd:COG2319  315 WDLAT-GKLLRTLTG--HTGAVRSVAFSPDGKTLASG 348
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 92-412 5.30e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.58  E-value: 5.30e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386  92 AVMEGFKKPATCCAVDRSGARMAAGSSDGVVRLYDFNGMkrdlQPFRSIAPREGyPIHAVDWSPTGDMFVAASGSWQPTV 171
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG----ELLRTLKGHTG-PVRDVAASADGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 172 HD-RDGVELGEFdkgdmyirdlrntKGHVAATTDVKWNPlDKETICTAGEDGALRLWDVtylgdARGSQKAVLKPQQvkp 250
Cdd:cd00200   78 WDlETGECVRTL-------------TGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDV-----ETGKCLTTLRGHT--- 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 251 grVQVTSCAYSHDGDLIAGGITDGSVQIFSSKGSH--HLFKGaHPagEEVTSLSFGRDGRTLLSRCEDGTLNVWDLRNvK 328
Cdd:cd00200  136 --DWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKcvATLTG-HT--GEVNSVAFSPDGEKLLSSSSDGTIKLWDLST-G 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 329 APLKRFedlpTRHSE--TTVGWSPNDVYFFtgvdaerdsrGGNTQGGLCFFDREKLEMVHRVSTPTN-CIAATWHPRLNQ 405
Cdd:cd00200  210 KCLGTL----RGHENgvNSVAFSPDGYLLA----------SGSEDGTIRVWDLRTGECVQTLSGHTNsVTSLAWSPDGKR 275


                 ....*..
gi 145349386 406 IFVGCGD 412
Cdd:cd00200  276 LASGSAD 282
WD40 COG2319
WD40 repeat [General function prediction only];
84-358 2.12e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 114.62  E-value: 2.12e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386  84 DAIPRAAEAVMEGFKKPATCCAVDRSGARMAAGSSDGVVRLYDFngmkRDLQPFRSIAPREGyPIHAVDWSPTGDMFvaA 163
Cdd:COG2319  148 DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL----ATGKLLRTLTGHTG-AVRSVAFSPDGKLL--A 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 164 SGSWQPTVH--DRDGVELgefdkgdmyirdLRNTKGHVAATTDVKWNPlDKETICTAGEDGALRLWDVtylgdARGSQKA 241
Cdd:COG2319  221 SGSADGTVRlwDLATGKL------------LRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDL-----ATGELLR 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 242 VLKPQQVkpgrvQVTSCAYSHDGDLIAGGITDGSVQIFSSKgSHHLFKGAHPAGEEVTSLSFGRDGRTLLSRCEDGTLNV 321
Cdd:COG2319  283 TLTGHSG-----GVNSVAFSPDGKLLASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 145349386 322 WDLRNVKaPLKRFedlpTRHSE--TTVGWSPNDVYFFTG 358
Cdd:COG2319  357 WDLATGE-LLRTL----TGHTGavTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
21-421 5.11e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 5.11e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386  21 AFPTAFGRGGGAGATARDVVDDGARATAALGARDDDDDDGGGGGGGGGGEADRGSGEEEYEEEDAIPRAAEAVMEGFKKP 100
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 101 ATCCAVDRSGARMAAGSSDGVVRLYDFNGmkrdLQPFRSIAPREGyPIHAVDWSPTGDMFVAASGSWQPTVHD-RDGVEL 179
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLAT----GLLLRTLTGHTG-AVRSVAFSPDGKTLASGSADGTVRLWDlATGKLL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 180 GEFdkgdmyirdlrntKGHVAATTDVKWNPlDKETICTAGEDGALRLWDVtylgdARGSQKAVLKPQQvkpgrVQVTSCA 259
Cdd:COG2319  156 RTL-------------TGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDL-----ATGKLLRTLTGHT-----GAVRSVA 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 260 YSHDGDLIAGGITDGSVQIFSSKGSHHLFKGAHPAGeEVTSLSFGRDGRTLLSRCEDGTLNVWDLRNvKAPLKRFEDLPT 339
Cdd:COG2319  212 FSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSG-SVRSVAFSPDGRLLASGSADGTVRLWDLAT-GELLRTLTGHSG 289

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 340 RHseTTVGWSPNDVYFFTgvdaerdsrgGNTQGGLCFFDREKLEMVHRVSTPTNCI-AATWHPRLNQIFVGCGD------ 412
Cdd:COG2319  290 GV--NSVAFSPDGKLLAS----------GSDDGTVRLWDLATGKLLRTLTGHTGAVrSVAFSPDGKTLASGSDDgtvrlw 357

                        410
                 ....*....|.
gi 145349386 413 --AKGGELRVL 421
Cdd:COG2319  358 dlATGELLRTL 368
WD40 COG2319
WD40 repeat [General function prediction only];
92-326 2.91e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 2.91e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386  92 AVMEGFKKPATCCAVDRSGARMAAGSSDGVVRLYDFNGMKRdLQPFRSiaprEGYPIHAVDWSPTGDMFvaASGSWQPTV 171
Cdd:COG2319  198 RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL-LRTLTG----HSGSVRSVAFSPDGRLL--ASGSADGTV 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 172 H--DRDGVELgefdkgdmyirdLRNTKGHVAATTDVKWNPlDKETICTAGEDGALRLWDVtylgdARGSQKAVLKPQqvk 249
Cdd:COG2319  271 RlwDLATGEL------------LRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDL-----ATGKLLRTLTGH--- 329

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 145349386 250 pgRVQVTSCAYSHDGDLIAGGITDGSVQIFSSKGSHHL--FKGaHPAGeeVTSLSFGRDGRTLLSRCEDGTLNVWDLRN 326
Cdd:COG2319  330 --TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLrtLTG-HTGA--VTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-358 4.31e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 99.72  E-value: 4.31e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386  84 DAIPRAAEAVMEGFKKPATCCAVDRSGARMAAGSSDGVVRLYDFNgmkrDLQPFRSIAPREGYpIHAVDWSPtgDMFVAA 163
Cdd:cd00200   37 DLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE----TGECVRTLTGHTSY-VSSVAFSP--DGRILS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 164 SGSWQPTVHDRDgVELGEFdkgdmyirdLRNTKGHVAATTDVKWNPlDKETICTAGEDGALRLWDVTYlgdargsqkavL 243
Cdd:cd00200  110 SSSRDKTIKVWD-VETGKC---------LTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRT-----------G 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 244 KPQQVKPG-RVQVTSCAYSHDGDLIAGGITDGSVQIFSSKG--SHHLFKGaHPAGeeVTSLSFGRDGRTLLSRCEDGTLN 320
Cdd:cd00200  168 KCVATLTGhTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTgkCLGTLRG-HENG--VNSVAFSPDGYLLASGSEDGTIR 244

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 145349386 321 VWDLRNvKAPLKRFedlpTRHSE--TTVGWSPNDVYFFTG 358
Cdd:cd00200  245 VWDLRT-GECVQTL----SGHTNsvTSLAWSPDGKRLASG 279
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 92-228 1.74e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.13  E-value: 1.74e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386  92 AVMEGFKKPATCCAVDRSGARMAAGSSDGVVRLYdfngmkrDLQPFRSIAPREG--YPIHAVDWSPTGDMFVAASgswqp 169
Cdd:cd00200  171 ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW-------DLSTGKCLGTLRGheNGVNSVAFSPDGYLLASGS----- 238

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145349386 170 tvhdRDGVelgefdkgdMYIRDLRNTK------GHVAATTDVKWNPlDKETICTAGEDGALRLWD 228
Cdd:cd00200  239 ----EDGT---------IRVWDLRTGEcvqtlsGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 207-331 1.09e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 1.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 207 WNPLDKETICTAGEDGALRLWDVtylgdARGSQKAVLKPQQVKPGRVQVTSCayshDGDLIAGGITDGSVQIFSSKGSHH 286
Cdd:PLN00181 540 WNSYIKSQVASSNFEGVVQVWDV-----ARSQLVTEMKEHEKRVWSIDYSSA----DPTLLASGSDDGSVKLWSINQGVS 610

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 145349386 287 LfkGAHPAGEEVTSLSFGRD-GRTLLSRCEDGTLNVWDLRNVKAPL 331
Cdd:PLN00181 611 I--GTIKTKANICCVQFPSEsGRSLAFGSADHKVYYYDLRNPKLPL 654
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 265-351 1.80e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 40.72  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386  265 DLIAGGITDGSVQIFSSKGsHHLFKGAHPA-GEEVTSLSFGRDGRTLLSRCEDGTLNVWDLRNVKaPLKRFEdlPTRHSE 343
Cdd:pfam12894   8 DLIALATEDGELLLHRLNW-QRVWTLSPDKeDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGK-IVHHFS--AGSDLI 83


                  ....*...
gi 145349386  344 TTVGWSPN 351
Cdd:pfam12894  84 TCLGWGEN 91
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 284-435 2.88e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 2.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 284 SHHLFKGaHPAGeeVTSLSFGRDGRTLLSRCEDGTLNVWDLRNvKAPLKRFEDlptrHSE--TTVGWSPNDVYFFTGvda 361
Cdd:cd00200    1 LRRTLKG-HTGG--VTCVAFSPDGKLLATGSGDGTIKVWDLET-GELLRTLKG----HTGpvRDVAASADGTYLASG--- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386 362 erdsrGGNtqGGLCFFDREKLEMVHRVST---PTNCIAatWHPrLNQIFVGCGDAKggELRV----LYDPKKSMGGITQA 434
Cdd:cd00200   70 -----SSD--KTIRLWDLETGECVRTLTGhtsYVSSVA--FSP-DGRILSSSSRDK--TIKVwdveTGKCLTTLRGHTDW 137


                 .
gi 145349386 435 V 435
Cdd:cd00200  138 V 138
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 147-284 4.14e-04

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 41.87  E-value: 4.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386  147 PIHAVDWSPTGDMFVAASGsWQP---TVHDRDGVELGEFDKGDmyirdlRNTkghvaattdVKWNPLDKeTICTAG---E 220
Cdd:pfam08662  61 PIHDVAWSPNGKEFAVIYG-YMPakvSFFDLKGNVIHSFGEQP------RNT---------IFWSPFGR-LVLLAGfgnL 123

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145349386  221 DGALRLWDVtylgdargSQKAVLKPQQVKpgrvQVTSCAYSHDGDLIAGGIT------DGSVQIFSSKGS 284
Cdd:pfam08662 124 AGDIEFWDV--------VNKKKIATAEAS----NATLCEWSPDGRYFLTATTaprlrvDNGFKIWHYNGA 181
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 196-228 4.80e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 4.80e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 145349386   196 KGHVAATTDVKWNPlDKETICTAGEDGALRLWD 228
Cdd:smart00320   9 KGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 92-126 1.14e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.14e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 145349386    92 AVMEGFKKPATCCAVDRSGARMAAGSSDGVVRLYD 126
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
192-228 5.13e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 5.13e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 145349386  192 LRNTKGHVAATTDVKWNPlDKETICTAGEDGALRLWD 228
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 296-323 7.80e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 7.80e-03
                           10        20
                   ....*....|....*....|....*...
gi 145349386   296 EEVTSLSFGRDGRTLLSRCEDGTLNVWD 323
Cdd:smart00320  13 GPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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