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Conserved domains on  [gi|1622947204|ref|XP_001112630|]
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GDNF family receptor alpha-3 [Macaca mulatta]

Protein Classification

GDNF family receptor alpha( domain architecture ID 10658249)

glial cell line-derived neurotrophic factor (GDNF) family receptor alpha is a glycosylphosphatidylinositol-linked cell surface receptor for GDNF, the glial cell line-derived neurotrophic factor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 253-345 1.73e-21

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 460537  Cd Length: 87  Bit Score: 87.97  E-value: 1.73e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947204 253 CLELRRLCFSDPLCRSRLVDFQAHCHPMDILGTCATEQSRCLRAYlgligtAMTPNFVSNVNTSVALSCTCRGSGNLQEE 332
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCPNPARCLRAY------RMTPNYVDNLGTSLLLWCTCKGSGNQDEE 74

                          90
                  ....*....|...
gi 1622947204 333 CEQLEGFFSHNPC 345
Cdd:pfam02351  75 CEEFRRNFTVNSC 87
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 167-244 6.19e-08

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 460537  Cd Length: 87  Bit Score: 49.84  E-value: 6.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947204 167 CLKFAMLCTLNDKCDRLRKAYGEAC--SGPHCQRHV----CLRQLLTFFEKAAEPHAQGLLLCPCA---PNDRGCGERRR 237
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCqpSPESCSGCPnparCLRAYRMTPNYVDNLGTSLLLWCTCKgsgNQDEECEEFRR 80


                  ....*..
gi 1622947204 238 NTIAPSC 244
Cdd:pfam02351  81 NFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 49-129 2.67e-07

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 197975  Cd Length: 86  Bit Score: 48.02  E-value: 2.67e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947204   49 CLQARRKCQADPIC-SAAYHHLDSCTSSISTPLPSEepsVPADCLEAAQQLRNSSLIG--------CMCHRrmKNQVACL 119
Cdd:smart00907   1 CLEALKACELDPVCrSRLADYLSACSPSPSSSCPGE---NSEACLRAYCGLALRPFYDdnssvllfCTCAG--NRDEECL 75

                           90
                   ....*....|
gi 1622947204  120 DIYWTVHRAR 129
Cdd:smart00907  76 EFRRLFHSNP 85
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 253-345 1.73e-21

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 87.97  E-value: 1.73e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947204 253 CLELRRLCFSDPLCRSRLVDFQAHCHPMDILGTCATEQSRCLRAYlgligtAMTPNFVSNVNTSVALSCTCRGSGNLQEE 332
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCPNPARCLRAY------RMTPNYVDNLGTSLLLWCTCKGSGNQDEE 74

                          90
                  ....*....|...
gi 1622947204 333 CEQLEGFFSHNPC 345
Cdd:pfam02351  75 CEEFRRNFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 253-345 2.49e-14

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 68.05  E-value: 2.49e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947204  253 CLELRRLCFSDPLCRSRLVDFQAHCHPMDILGTCATEQSRCLRAYlglIGTAMTPNFVSnvNTSVALSCTCRgsGNLQEE 332
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSSCPGENSEACLRAY---CGLALRPFYDD--NSSVLLFCTCA--GNRDEE 73

                           90
                   ....*....|...
gi 1622947204  333 CEQLEGFFSHNPC 345
Cdd:smart00907  74 CLEFRRLFHSNPC 86
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 167-244 6.19e-08

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 49.84  E-value: 6.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947204 167 CLKFAMLCTLNDKCDRLRKAYGEAC--SGPHCQRHV----CLRQLLTFFEKAAEPHAQGLLLCPCA---PNDRGCGERRR 237
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCqpSPESCSGCPnparCLRAYRMTPNYVDNLGTSLLLWCTCKgsgNQDEECEEFRR 80


                  ....*..
gi 1622947204 238 NTIAPSC 244
Cdd:pfam02351  81 NFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 167-244 1.40e-07

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 48.79  E-value: 1.40e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947204  167 CLKFAMLCTLNDKCDRLRKAYGEACSG-----------PHCQRHVCLRQLLTFFekaaEPHAQGLLLCPCAPNDR-GCGE 234
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPspssscpgensEACLRAYCGLALRPFY----DDNSSVLLFCTCAGNRDeECLE 76

                           90
                   ....*....|
gi 1622947204  235 RRRNTIAPSC 244
Cdd:smart00907  77 FRRLFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 49-129 2.67e-07

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 48.02  E-value: 2.67e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947204   49 CLQARRKCQADPIC-SAAYHHLDSCTSSISTPLPSEepsVPADCLEAAQQLRNSSLIG--------CMCHRrmKNQVACL 119
Cdd:smart00907   1 CLEALKACELDPVCrSRLADYLSACSPSPSSSCPGE---NSEACLRAYCGLALRPFYDdnssvllfCTCAG--NRDEECL 75

                           90
                   ....*....|
gi 1622947204  120 DIYWTVHRAR 129
Cdd:smart00907  76 EFRRLFHSNP 85
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 49-127 2.61e-03

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 36.74  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947204  49 CLQARRKCQADPICSAAYH-HLDSCTSSISTPLPSEEpsvPADCLEAAQQLRN-------SSLIGCMCHRRMKNQVACLD 120
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLAdFQSNCQPSPESCSGCPN---PARCLRAYRMTPNyvdnlgtSLLLWCTCKGSGNQDEECEE 77


                  ....*..
gi 1622947204 121 IYWTVHR 127
Cdd:pfam02351  78 FRRNFTV 84
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 253-345 1.73e-21

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 87.97  E-value: 1.73e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947204 253 CLELRRLCFSDPLCRSRLVDFQAHCHPMDILGTCATEQSRCLRAYlgligtAMTPNFVSNVNTSVALSCTCRGSGNLQEE 332
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCPNPARCLRAY------RMTPNYVDNLGTSLLLWCTCKGSGNQDEE 74

                          90
                  ....*....|...
gi 1622947204 333 CEQLEGFFSHNPC 345
Cdd:pfam02351  75 CEEFRRNFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 253-345 2.49e-14

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 68.05  E-value: 2.49e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947204  253 CLELRRLCFSDPLCRSRLVDFQAHCHPMDILGTCATEQSRCLRAYlglIGTAMTPNFVSnvNTSVALSCTCRgsGNLQEE 332
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSSCPGENSEACLRAY---CGLALRPFYDD--NSSVLLFCTCA--GNRDEE 73

                           90
                   ....*....|...
gi 1622947204  333 CEQLEGFFSHNPC 345
Cdd:smart00907  74 CLEFRRLFHSNPC 86
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 167-244 6.19e-08

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 49.84  E-value: 6.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947204 167 CLKFAMLCTLNDKCDRLRKAYGEAC--SGPHCQRHV----CLRQLLTFFEKAAEPHAQGLLLCPCA---PNDRGCGERRR 237
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCqpSPESCSGCPnparCLRAYRMTPNYVDNLGTSLLLWCTCKgsgNQDEECEEFRR 80


                  ....*..
gi 1622947204 238 NTIAPSC 244
Cdd:pfam02351  81 NFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 167-244 1.40e-07

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 48.79  E-value: 1.40e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947204  167 CLKFAMLCTLNDKCDRLRKAYGEACSG-----------PHCQRHVCLRQLLTFFekaaEPHAQGLLLCPCAPNDR-GCGE 234
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPspssscpgensEACLRAYCGLALRPFY----DDNSSVLLFCTCAGNRDeECLE 76

                           90
                   ....*....|
gi 1622947204  235 RRRNTIAPSC 244
Cdd:smart00907  77 FRRLFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 49-129 2.67e-07

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 48.02  E-value: 2.67e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947204   49 CLQARRKCQADPIC-SAAYHHLDSCTSSISTPLPSEepsVPADCLEAAQQLRNSSLIG--------CMCHRrmKNQVACL 119
Cdd:smart00907   1 CLEALKACELDPVCrSRLADYLSACSPSPSSSCPGE---NSEACLRAYCGLALRPFYDdnssvllfCTCAG--NRDEECL 75

                           90
                   ....*....|
gi 1622947204  120 DIYWTVHRAR 129
Cdd:smart00907  76 EFRRLFHSNP 85
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 49-127 2.61e-03

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 36.74  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947204  49 CLQARRKCQADPICSAAYH-HLDSCTSSISTPLPSEEpsvPADCLEAAQQLRN-------SSLIGCMCHRRMKNQVACLD 120
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLAdFQSNCQPSPESCSGCPN---PARCLRAYRMTPNyvdnlgtSLLLWCTCKGSGNQDEECEE 77


                  ....*..
gi 1622947204 121 IYWTVHR 127
Cdd:pfam02351  78 FRRNFTV 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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