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Conserved domains on  [gi|1622863354|ref|XP_001111210|]
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zinc finger protein 408 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 53-176 1.26e-49

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


:

Pssm-ID: 380918  Cd Length: 121  Bit Score: 169.52  E-value: 1.26e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354  53 ALKSLPRGLALGPSLAKEQRLGVWCVGEPLQPGLLWGPLEEESVSKEKGEGVKPRQEEnlsLGPWGDMCACEQSSGWTGL 132
Cdd:cd10520     1 ALRSLPPGLALGPSLAQEERLGVWCVGDALQKGTFLGPLEEELESHDLTEGGSPRQEE---SGQSGDVLACEQSSKWMRF 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1622863354 133 VQRGRLESEGNVAPVRISERLHLQVYQLVLPGFELLLWPWPSSE 176
Cdd:cd10520    78 ACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELLLWPEENGA 121
zf-H2C2_2 pfam13465
Zinc-finger double domain;
481-506 1.90e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.67  E-value: 1.90e-06
                          10        20
                  ....*....|....*....|....*.
gi 1622863354 481 SLRNHMRLHTGEKPFLCPHCGRAFRQ 506
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
221-628 2.66e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 2.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354 221 SHSPPGIQAESMVSPGLKFP---TQDQLSKDSQPLGPLLQDGNMDEEYPPQAQMPPelqSNSATQQDPDGSGASFSSARG 297
Cdd:COG5048    57 TGEKPSQCSYSGCDKSFSRPlelSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS---SSSNSNDNNLLSSHSLPPSSR 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354 298 TQLRGYLVKKLHSPNDQCPP--RAKAPEPGAqqpgfptLSRSPPGPAGSSPKQGRRYRCGECGKAFLQ--LCHLKKHAFV 373
Cdd:COG5048   134 DPQLPDLLSISNLRNNPLPGnnSSSVNTPQS-------NSLHPPLPANSLSKDPSSNLSLLISSNVSTsiPSSSENSPLS 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354 374 HTGHKPFLCTECGKSYSSEeSFKAHVLGHRGVRPFPCPQcdkaygtQRDLKEHQVVHSGARPFACDQCGKAFARRPSLRL 453
Cdd:COG5048   207 SSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQS-------PSSLSSSDSSSSASESPRSSLPTASSQSSSPNES 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354 454 HRKTHQVPTAPAPCPCpvCGRPLANQGSLRNHMR--LHTGE--KPFLCPH--CGRAFRQRGNLRGHLRLHTGERPYRCPh 527
Cdd:COG5048   279 DSSSEKGFSLPIKSKQ--CNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK- 355

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354 528 cadafpqlpeLRRHLISHTGEAHLCPVcgkALRDPHTLRAHERLHSGERPFPCPQCGRAYTLATKLRRHLKShlEDKPYR 607
Cdd:COG5048   356 ----------LLNSSSKFSPLLNNEPP---QSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSF--RPYNCK 420

                         410       420
                  ....*....|....*....|.
gi 1622863354 608 CPTCGMGYTLPQSLRRHQLSH 628
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIH 441
 
Name Accession Description Interval E-value
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 53-176 1.26e-49

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 169.52  E-value: 1.26e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354  53 ALKSLPRGLALGPSLAKEQRLGVWCVGEPLQPGLLWGPLEEESVSKEKGEGVKPRQEEnlsLGPWGDMCACEQSSGWTGL 132
Cdd:cd10520     1 ALRSLPPGLALGPSLAQEERLGVWCVGDALQKGTFLGPLEEELESHDLTEGGSPRQEE---SGQSGDVLACEQSSKWMRF 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1622863354 133 VQRGRLESEGNVAPVRISERLHLQVYQLVLPGFELLLWPWPSSE 176
Cdd:cd10520    78 ACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELLLWPEENGA 121
zf-H2C2_2 pfam13465
Zinc-finger double domain;
481-506 1.90e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.67  E-value: 1.90e-06
                          10        20
                  ....*....|....*....|....*.
gi 1622863354 481 SLRNHMRLHTGEKPFLCPHCGRAFRQ 506
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
221-628 2.66e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 2.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354 221 SHSPPGIQAESMVSPGLKFP---TQDQLSKDSQPLGPLLQDGNMDEEYPPQAQMPPelqSNSATQQDPDGSGASFSSARG 297
Cdd:COG5048    57 TGEKPSQCSYSGCDKSFSRPlelSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS---SSSNSNDNNLLSSHSLPPSSR 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354 298 TQLRGYLVKKLHSPNDQCPP--RAKAPEPGAqqpgfptLSRSPPGPAGSSPKQGRRYRCGECGKAFLQ--LCHLKKHAFV 373
Cdd:COG5048   134 DPQLPDLLSISNLRNNPLPGnnSSSVNTPQS-------NSLHPPLPANSLSKDPSSNLSLLISSNVSTsiPSSSENSPLS 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354 374 HTGHKPFLCTECGKSYSSEeSFKAHVLGHRGVRPFPCPQcdkaygtQRDLKEHQVVHSGARPFACDQCGKAFARRPSLRL 453
Cdd:COG5048   207 SSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQS-------PSSLSSSDSSSSASESPRSSLPTASSQSSSPNES 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354 454 HRKTHQVPTAPAPCPCpvCGRPLANQGSLRNHMR--LHTGE--KPFLCPH--CGRAFRQRGNLRGHLRLHTGERPYRCPh 527
Cdd:COG5048   279 DSSSEKGFSLPIKSKQ--CNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK- 355

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354 528 cadafpqlpeLRRHLISHTGEAHLCPVcgkALRDPHTLRAHERLHSGERPFPCPQCGRAYTLATKLRRHLKShlEDKPYR 607
Cdd:COG5048   356 ----------LLNSSSKFSPLLNNEPP---QSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSF--RPYNCK 420

                         410       420
                  ....*....|....*....|.
gi 1622863354 608 CPTCGMGYTLPQSLRRHQLSH 628
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
509-532 1.79e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.79e-04
                          10        20
                  ....*....|....*....|....
gi 1622863354 509 NLRGHLRLHTGERPYRCPHCADAF 532
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
PHA00733 PHA00733
hypothetical protein
 522-568 4.00e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.93  E-value: 4.00e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1622863354 522 PYRCPHCADAFPQLPELRRHlISHTGEAHLCPVCGKALRDPHTLRAH 568
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQH-IRYTEHSKVCPVCGKEFRNTDSTLDH 118
 
Name Accession Description Interval E-value
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 53-176 1.26e-49

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 169.52  E-value: 1.26e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354  53 ALKSLPRGLALGPSLAKEQRLGVWCVGEPLQPGLLWGPLEEESVSKEKGEGVKPRQEEnlsLGPWGDMCACEQSSGWTGL 132
Cdd:cd10520     1 ALRSLPPGLALGPSLAQEERLGVWCVGDALQKGTFLGPLEEELESHDLTEGGSPRQEE---SGQSGDVLACEQSSKWMRF 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1622863354 133 VQRGRLESEGNVAPVRISERLHLQVYQLVLPGFELLLWPWPSSE 176
Cdd:cd10520    78 ACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELLLWPEENGA 121
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 57-170 3.82e-13

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 65.30  E-value: 3.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354  57 LPRGLALGPSLAKEQRLGVWCVgEPLQPGLLWGPLEeesvskekgegvkprqeenlslGPWGdmcaceqssgWTGLVQRG 136
Cdd:cd10534     1 LPAGLELVLSSIPEGGLGVFAR-RTIPAGTRFGPLE----------------------GVVN----------WMRFVRPA 47

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1622863354 137 RLESEGNVAPVRISERLHLQVYQLVLPGFELLLW 170
Cdd:cd10534    48 RNEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVW 81
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 54-170 1.55e-06

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 47.82  E-value: 1.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354  54 LKSLPRGLALGPSLAKEQRLGVWCVgEPLQPGLLWGPLEEEsvSKEKGEGVKPRQEENLSLGPWGDMC--ACEQSSG-WT 130
Cdd:cd19188     1 LMGLPEELELKPSAVDKTRIGVWAK-KSIPKGRKFGPFVGE--KKKRSQVKNNVYMWEIYGPKRGWMCvdASDPTKGnWL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1622863354 131 GLVQRGRLESEGNVAPVRISERLHLQVYQLVLPGFELLLW 170
Cdd:cd19188    78 RYVNWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCW 117
zf-H2C2_2 pfam13465
Zinc-finger double domain;
481-506 1.90e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.67  E-value: 1.90e-06
                          10        20
                  ....*....|....*....|....*.
gi 1622863354 481 SLRNHMRLHTGEKPFLCPHCGRAFRQ 506
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
221-628 2.66e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 2.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354 221 SHSPPGIQAESMVSPGLKFP---TQDQLSKDSQPLGPLLQDGNMDEEYPPQAQMPPelqSNSATQQDPDGSGASFSSARG 297
Cdd:COG5048    57 TGEKPSQCSYSGCDKSFSRPlelSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS---SSSNSNDNNLLSSHSLPPSSR 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354 298 TQLRGYLVKKLHSPNDQCPP--RAKAPEPGAqqpgfptLSRSPPGPAGSSPKQGRRYRCGECGKAFLQ--LCHLKKHAFV 373
Cdd:COG5048   134 DPQLPDLLSISNLRNNPLPGnnSSSVNTPQS-------NSLHPPLPANSLSKDPSSNLSLLISSNVSTsiPSSSENSPLS 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354 374 HTGHKPFLCTECGKSYSSEeSFKAHVLGHRGVRPFPCPQcdkaygtQRDLKEHQVVHSGARPFACDQCGKAFARRPSLRL 453
Cdd:COG5048   207 SSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQS-------PSSLSSSDSSSSASESPRSSLPTASSQSSSPNES 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354 454 HRKTHQVPTAPAPCPCpvCGRPLANQGSLRNHMR--LHTGE--KPFLCPH--CGRAFRQRGNLRGHLRLHTGERPYRCPh 527
Cdd:COG5048   279 DSSSEKGFSLPIKSKQ--CNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK- 355

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354 528 cadafpqlpeLRRHLISHTGEAHLCPVcgkALRDPHTLRAHERLHSGERPFPCPQCGRAYTLATKLRRHLKShlEDKPYR 607
Cdd:COG5048   356 ----------LLNSSSKFSPLLNNEPP---QSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSF--RPYNCK 420

                         410       420
                  ....*....|....*....|.
gi 1622863354 608 CPTCGMGYTLPQSLRRHQLSH 628
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-515 5.90e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 5.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354 265 YPPQAQMPPELQSNSATQQDPDGSGASFSSARGTQLRGYLVKKlHSPNDQCPP--RAKAPEPGAQQPGFPTLSRSPPGPA 342
Cdd:COG5048   200 SENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLS-QSPSSLSSSdsSSSASESPRSSLPTASSQSSSPNES 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354 343 GSSPKQGR--RYRCGECGKAFLQLCHLKKH--AFVHTG--HKPFLCTE--CGKSYSSEESFKAHVLGHRGVRPFPCP--- 411
Cdd:COG5048   279 DSSSEKGFslPIKSKQCNISFSRSSPLTRHlrSVNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKlln 358

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354 412 ------QCDKAYGTQRDLKEHQVVHSgaRPFACD--QCGKAFARRPSLRLHRKTHqVPTAPAPCPCPVCGRPLANQGSLR 483
Cdd:COG5048   359 ssskfsPLLNNEPPQSLQQYKDLKND--KKSETLsnSCIRNFKRDSNLSLHIITH-LSFRPYNCKNPPCSKSFNRHYNLI 435

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1622863354 484 NHMRLHTgEKPFLCPHCGRAFRQRGNLRGHLR 515
Cdd:COG5048   436 PHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
509-532 1.79e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.79e-04
                          10        20
                  ....*....|....*....|....
gi 1622863354 509 NLRGHLRLHTGERPYRCPHCADAF 532
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 376-456 6.62e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 6.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354 376 GHKPFLC--TECGKSYSSEESFKAHVL-GHRGVRPFPCPQCDKaygtqrdlkeHQVVHSGARPFACDQCGKAFARRPSLR 452
Cdd:COG5189   346 DGKPYKCpvEGCNKKYKNQNGLKYHMLhGHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....
gi 1622863354 453 LHRK 456
Cdd:COG5189   416 YHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
593-616 6.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.95e-04
                          10        20
                  ....*....|....*....|....
gi 1622863354 593 LRRHLKSHLEDKPYRCPTCGMGYT 616
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
366-391 7.44e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.44e-04
                          10        20
                  ....*....|....*....|....*.
gi 1622863354 366 HLKKHAFVHTGHKPFLCTECGKSYSS 391
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 495-517 1.16e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 1.16e-03
                          10        20
                  ....*....|....*....|...
gi 1622863354 495 FLCPHCGRAFRQRGNLRGHLRLH 517
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 574-624 1.60e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.60e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622863354 574 GERPFPCP--QCGRAYTLATKLRRH-LKSH------------------LEDKPYRCPTCGMGYTLPQSLRRH 624
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHmLHGHqnqklhenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH 417
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 436-458 2.99e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.99e-03
                          10        20
                  ....*....|....*....|...
gi 1622863354 436 FACDQCGKAFARRPSLRLHRKTH 458
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 522-568 4.00e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.93  E-value: 4.00e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1622863354 522 PYRCPHCADAFPQLPELRRHlISHTGEAHLCPVCGKALRDPHTLRAH 568
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQH-IRYTEHSKVCPVCGKEFRNTDSTLDH 118
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 80-176 6.73e-03

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 37.32  E-value: 6.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354  80 EPLQPGLLWGP----LEEESVSKEKGEGVKPRqeeNLSLGPWGDMCACEqSSGWTGLVQRGRLESEGNVAPVRISERLHL 155
Cdd:cd19201    26 QPLPEGTRFGPypgkLVKEPLDPSYEWKVEAQ---GSKGGEGLLLLTED-SGTWLKLVRSADDEDEANLILYFKGGQIWC 101

                          90       100
                  ....*....|....*....|.
gi 1622863354 156 QVYQLVLPGFELLLWPWPSSE 176
Cdd:cd19201   102 EVTKDIPPGEELILVLREPLL 122
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
171-350 9.46e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.47  E-value: 9.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354 171 PWPSSEGPSLTHPRLDKEAAVEVVTEVGSAVQQEVASHGEDAAEPCTDPGShSPPGIQAESMVSPGLKFPTQDQLSKDSQ 250
Cdd:PRK12323  406 PAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAA-APAAAARPAAAGPRPVAAAAAAAPARAA 484

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863354 251 PLGpllQDGNMDEEYPPQAQMPPELQSNSATQQDPDGSGASFSSARGTQLRgylvkklhspnDQCPPRAKAPEPGAQQPG 330
Cdd:PRK12323  485 PAA---APAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATA-----------DPDDAFETLAPAPAAAPA 550

                         170       180
                  ....*....|....*....|
gi 1622863354 331 FPTLSRSPPGPAGSSPKQGR 350
Cdd:PRK12323  551 PRAAAATEPVVAPRPPRASA 570
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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