NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|109099149|ref|XP_001100820|]
View 

cyclin-dependent kinase 2-associated protein 1 isoform X3 [Macaca mulatta]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CDK2AP super family cl10779
Cyclin-dependent kinase 2-associated protein; Members of this family of proteins are ...
 37-131 1.47e-21

Cyclin-dependent kinase 2-associated protein; Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. An association between mutations in the gene coding for this protein and oral cancer has been described.


The actual alignment was detected with superfamily member pfam09806:

Pssm-ID: 430840  Cd Length: 211  Bit Score: 85.33  E-value: 1.47e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109099149   37 AGSVHSPSTSMASSQYRQLLSDYG-PPSLGYTQGTGNSQvpqSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHA 115
Cdd:pfam09806 119 AANGATGGRGLDSGLYGLAGAAISlDNNSGGSNSTANIV---DKYSNLLAVIAEMQRNLGPTAMGLRAPKERLLRDIAHA 195

                          90
                  ....*....|....*.
gi 109099149  116 RGLVRECLAETERNAR 131
Cdd:pfam09806 196 RVLVRECLLLLERDQR 211
 
Name Accession Description Interval E-value
CDK2AP pfam09806
Cyclin-dependent kinase 2-associated protein; Members of this family of proteins are ...
 37-131 1.47e-21

Cyclin-dependent kinase 2-associated protein; Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. An association between mutations in the gene coding for this protein and oral cancer has been described.


Pssm-ID: 430840  Cd Length: 211  Bit Score: 85.33  E-value: 1.47e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109099149   37 AGSVHSPSTSMASSQYRQLLSDYG-PPSLGYTQGTGNSQvpqSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHA 115
Cdd:pfam09806 119 AANGATGGRGLDSGLYGLAGAAISlDNNSGGSNSTANIV---DKYSNLLAVIAEMQRNLGPTAMGLRAPKERLLRDIAHA 195

                          90
                  ....*....|....*.
gi 109099149  116 RGLVRECLAETERNAR 131
Cdd:pfam09806 196 RVLVRECLLLLERDQR 211
 
Name Accession Description Interval E-value
CDK2AP pfam09806
Cyclin-dependent kinase 2-associated protein; Members of this family of proteins are ...
 37-131 1.47e-21

Cyclin-dependent kinase 2-associated protein; Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. An association between mutations in the gene coding for this protein and oral cancer has been described.


Pssm-ID: 430840  Cd Length: 211  Bit Score: 85.33  E-value: 1.47e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109099149   37 AGSVHSPSTSMASSQYRQLLSDYG-PPSLGYTQGTGNSQvpqSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHA 115
Cdd:pfam09806 119 AANGATGGRGLDSGLYGLAGAAISlDNNSGGSNSTANIV---DKYSNLLAVIAEMQRNLGPTAMGLRAPKERLLRDIAHA 195

                          90
                  ....*....|....*.
gi 109099149  116 RGLVRECLAETERNAR 131
Cdd:pfam09806 196 RVLVRECLLLLERDQR 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH