NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|109107993|ref|XP_001088039|]
View 

transforming growth factor beta activator LRRC32 [Macaca mulatta]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 18077502)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 19-277 1.02e-39

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd00116:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 319  Bit Score: 148.27  E-value: 1.02e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993  19 QHQDKVACkMVDKKVSCQGLG---LLQVPLVL--PPDTETLDLSGNQLRSI---LASPLGFYTA---LRHLDLSTNEINF 87
Cdd:cd00116   17 ELLPKLLC-LQVLRLEGNTLGeeaAKALASALrpQPSLKELCLSLNETGRIprgLQSLLQGLTKgcgLQELDLSDNALGP 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993  88 LQPGAFQALTH---LEHLSLAHNRLA-MATALSAGGLGPL-PRVTSLDLSGNSLYSGLLERLLGEAP---SLHTLSLAEN 159
Cdd:cd00116   96 DGCGVLESLLRsssLQELKLNNNGLGdRGLRLLAKGLKDLpPALEKLVLGRNRLEGASCEALAKALRanrDLKELNLANN 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 160 SLT-RLTRHTFRDMPA---LEQLDLHSNVLMDIEDGAFEG----LPHLTHLNLSRNSLT--CISDFSLQ------QLRVL 223
Cdd:cd00116  176 GIGdAGIRALAEGLKAncnLEVLDLNNNGLTDEGASALAEtlasLKSLEVLNLGDNNLTdaGAAALASAllspniSLLTL 255

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 109107993 224 DLSCNSIE--AFQTASQPQAEF-QLTWLDLRENKL------LHFPDLAAL-PRLIYLNLSNNLI 277
Cdd:cd00116  256 SLSCNDITddGAKDLAEVLAEKeSLLELDLRGNKFgeegaqLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
290-574 5.41e-18

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.91  E-value: 5.41e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 290 IHAPSEGWSALPLSTPNGNVSARPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRSGSLPCLMLLD 369
Cdd:COG4886   23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 370 LSHNALETlelgarALGSLRTLLLQGNALRDLPPyTFANLASLQRLNLQGNRVSPCGGPnepgpascvaFSGIASLRSLS 449
Cdd:COG4886  103 LSGNEELS------NLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEP----------LGNLTNLKSLD 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 450 LVDNEIELLRAGAFLHTPLTELDLSSNPgLEVATGALTGLEaSLEVLALQGNGLTVLQVDLPCFICLKRLNLAENRLSHL 529
Cdd:COG4886  166 LSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 109107993 530 PAWTQAVSLEVLDLRNNSFSLLPGSamGGLeTSLRRLYLQGNPLS 574
Cdd:COG4886  244 PELGNLTNLEELDLSNNQLTDLPPL--ANL-TNLKTLDLSNNQLT 285
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 19-277 1.02e-39

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 148.27  E-value: 1.02e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993  19 QHQDKVACkMVDKKVSCQGLG---LLQVPLVL--PPDTETLDLSGNQLRSI---LASPLGFYTA---LRHLDLSTNEINF 87
Cdd:cd00116   17 ELLPKLLC-LQVLRLEGNTLGeeaAKALASALrpQPSLKELCLSLNETGRIprgLQSLLQGLTKgcgLQELDLSDNALGP 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993  88 LQPGAFQALTH---LEHLSLAHNRLA-MATALSAGGLGPL-PRVTSLDLSGNSLYSGLLERLLGEAP---SLHTLSLAEN 159
Cdd:cd00116   96 DGCGVLESLLRsssLQELKLNNNGLGdRGLRLLAKGLKDLpPALEKLVLGRNRLEGASCEALAKALRanrDLKELNLANN 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 160 SLT-RLTRHTFRDMPA---LEQLDLHSNVLMDIEDGAFEG----LPHLTHLNLSRNSLT--CISDFSLQ------QLRVL 223
Cdd:cd00116  176 GIGdAGIRALAEGLKAncnLEVLDLNNNGLTDEGASALAEtlasLKSLEVLNLGDNNLTdaGAAALASAllspniSLLTL 255

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 109107993 224 DLSCNSIE--AFQTASQPQAEF-QLTWLDLRENKL------LHFPDLAAL-PRLIYLNLSNNLI 277
Cdd:cd00116  256 SLSCNDITddGAKDLAEVLAEKeSLLELDLRGNKFgeegaqLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-278 6.40e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.61  E-value: 6.40e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993  38 LGLLQVPLVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEINFLQPGAFQALTHLEHLSLAHNRlamatalsa 117
Cdd:COG4886   37 LLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE--------- 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 118 gGLGPLPRVTSLDLSGNSLYSglLERLLGEAPSLHTLSLAENSLTRLTRhTFRDMPALEQLDLHSNVLMDIeDGAFEGLP 197
Cdd:COG4886  108 -ELSNLTNLESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLT 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 198 HLTHLNLSRNSLTCISD--FSLQQLRVLDLSCNSIEAFqtaSQPQAEF-QLTWLDLRENKLLHFPDLAALPRLIYLNLSN 274
Cdd:COG4886  183 NLKELDLSNNQITDLPEplGNLTNLEELDLSGNQLTDL---PEPLANLtNLETLDLSNNQLTDLPELGNLTNLEELDLSN 259


                 ....
gi 109107993 275 NLIR 278
Cdd:COG4886  260 NQLT 263
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
290-574 5.41e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.91  E-value: 5.41e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 290 IHAPSEGWSALPLSTPNGNVSARPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRSGSLPCLMLLD 369
Cdd:COG4886   23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 370 LSHNALETlelgarALGSLRTLLLQGNALRDLPPyTFANLASLQRLNLQGNRVSPCGGPnepgpascvaFSGIASLRSLS 449
Cdd:COG4886  103 LSGNEELS------NLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEP----------LGNLTNLKSLD 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 450 LVDNEIELLRAGAFLHTPLTELDLSSNPgLEVATGALTGLEaSLEVLALQGNGLTVLQVDLPCFICLKRLNLAENRLSHL 529
Cdd:COG4886  166 LSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 109107993 530 PAWTQAVSLEVLDLRNNSFSLLPGSamGGLeTSLRRLYLQGNPLS 574
Cdd:COG4886  244 PELGNLTNLEELDLSNNQLTDLPPL--ANL-TNLKTLDLSNNQLT 285
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 49-476 1.04e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 81.05  E-value: 1.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993  49 PDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEINFLQPGAFQALTHLEHLSLAHNRLamaTALSAGGLGPLPRVTS 128
Cdd:PLN00113 140 PNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQL---VGQIPRELGQMKSLKW 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 129 LDLSGNSLySGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPHLTHLNLSRNS 208
Cdd:PLN00113 217 IYLGYNNL-SGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNS 295

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 209 LTC-ISDF--SLQQLRVLDLSCNSIeafqTASQPQAefqltwldlrenkllhfpdLAALPRLIYLNLSNNliRLPTGPPQ 285
Cdd:PLN00113 296 LSGeIPELviQLQNLEILHLFSNNF----TGKIPVA-------------------LTSLPRLQVLQLWSN--KFSGEIPK 350

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 286 DsKGIHapsEGWSALPLST-------PNGNVSARPLSQL--------------LNLDLSYNEIELIPDSFLEHLTS---- 340
Cdd:PLN00113 351 N-LGKH---NNLTVLDLSTnnltgeiPEGLCSSGNLFKLilfsnslegeipksLGACRSLRRVRLQDNSFSGELPSeftk 426

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 341 ---LCFLNLSRNCLRTFEARRSGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNL 417
Cdd:PLN00113 427 lplVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKL 506

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 109107993 418 QGNRVSpcgG--PNEpgpascvaFSGIASLRSLSLVDNEIELLRAGAFLHTP-LTELDLSSN 476
Cdd:PLN00113 507 SENKLS---GeiPDE--------LSSCKKLVSLDLSHNQLSGQIPASFSEMPvLSQLDLSQN 557
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 199-423 1.15e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.50  E-value: 1.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 199 LTHLNLSRNSLTCISDFSL-QQLRVLDLscnsieafqtasqpqaefqltwldlRENKLLHFPDLAALPRLIYLNLSNNLI 277
Cdd:cd21340    4 ITHLYLNDKNITKIDNLSLcKNLKVLYL-------------------------YDNKITKIENLEFLTNLTHLYLQNNQI 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 278 RlptgppqdskgihapsegwSALPLSTpngnvsarpLSQLLNLDLSYNEIELIpdSFLEHLTSLCFLNLSRNCLR----- 352
Cdd:cd21340   59 E-------------------KIENLEN---------LVNLKKLYLGGNRISVV--EGLENLTNLEELHIENQRLPpgekl 108

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 109107993 353 TFEARRSGSL-PCLMLLDLSHNALETLElGARALGSLRTLLLQGNALRDLPP--YTFANLASLQRLNLQGNRVS 423
Cdd:cd21340  109 TFDPRSLAALsNSLRVLNISGNNIDSLE-PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVC 181
LRR_8 pfam13855
Leucine rich repeat;
149-209 5.82e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 5.82e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 109107993  149 PSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPHLTHLNLSRNSL 209
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 125-574 1.62e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.57  E-value: 1.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 125 RVTSLDLSGNSLySGllerllgeapslhtlslaensltRLTRHTFRdMPALEQLDLHSNVLM-DIEDGAFEGLPHLTHLN 203
Cdd:PLN00113  70 RVVSIDLSGKNI-SG-----------------------KISSAIFR-LPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLN 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 204 LSRNSLT-CISDFSLQQLRVLDLSCNSIeafqTASQPQ---AEFQLTWLDLRENKLL-HFP-DLAALPRLIYLNLSNNli 277
Cdd:PLN00113 125 LSNNNFTgSIPRGSIPNLETLDLSNNML----SGEIPNdigSFSSLKVLDLGGNVLVgKIPnSLTNLTSLEFLTLASN-- 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 278 RLPTGPPQDSKGIHapSEGWSALPLSTPNGNVSAR--PLSQLLNLDLSYNEIE-LIPDSfLEHLTSLCFLNLSRNCLRTF 354
Cdd:PLN00113 199 QLVGQIPRELGQMK--SLKWIYLGYNNLSGEIPYEigGLTSLNHLDLVYNNLTgPIPSS-LGNLKNLQYLFLYQNKLSGP 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 355 EARRSGSLPCLMLLDLSHNAL--ETLELGARaLGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSpcGG-PNEP 431
Cdd:PLN00113 276 IPPSIFSLQKLISLDLSDNSLsgEIPELVIQ-LQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFS--GEiPKNL 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 432 GPAScvafsgiaSLRSLSLVDNEIE------LLRAGAflhtpLTELDLSSNpGLEVATGALTGLEASLEVLALQGNGL-- 503
Cdd:PLN00113 353 GKHN--------NLTVLDLSTNNLTgeipegLCSSGN-----LFKLILFSN-SLEGEIPKSLGACRSLRRVRLQDNSFsg 418

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 504 ------TVLQV--------------------DLPcfiCLKRLNLAENRLS-HLPAWTQAVSLEVLDLRNNSFSLLPGSAM 556
Cdd:PLN00113 419 elpsefTKLPLvyfldisnnnlqgrinsrkwDMP---SLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPRKL 495

                        490
                 ....*....|....*...
gi 109107993 557 GGLeTSLRRLYLQGNPLS 574
Cdd:PLN00113 496 GSL-SELMQLKLSENKLS 512
LRR_8 pfam13855
Leucine rich repeat;
315-375 3.41e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 3.41e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 109107993  315 SQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRSGSLPCLMLLDLSHNAL 375
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
21-52 2.09e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.53  E-value: 2.09e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 109107993    21 QDKVACKMVDKKVSCQGLGLLQVPLVLPPDTE 52
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 19-277 1.02e-39

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 148.27  E-value: 1.02e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993  19 QHQDKVACkMVDKKVSCQGLG---LLQVPLVL--PPDTETLDLSGNQLRSI---LASPLGFYTA---LRHLDLSTNEINF 87
Cdd:cd00116   17 ELLPKLLC-LQVLRLEGNTLGeeaAKALASALrpQPSLKELCLSLNETGRIprgLQSLLQGLTKgcgLQELDLSDNALGP 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993  88 LQPGAFQALTH---LEHLSLAHNRLA-MATALSAGGLGPL-PRVTSLDLSGNSLYSGLLERLLGEAP---SLHTLSLAEN 159
Cdd:cd00116   96 DGCGVLESLLRsssLQELKLNNNGLGdRGLRLLAKGLKDLpPALEKLVLGRNRLEGASCEALAKALRanrDLKELNLANN 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 160 SLT-RLTRHTFRDMPA---LEQLDLHSNVLMDIEDGAFEG----LPHLTHLNLSRNSLT--CISDFSLQ------QLRVL 223
Cdd:cd00116  176 GIGdAGIRALAEGLKAncnLEVLDLNNNGLTDEGASALAEtlasLKSLEVLNLGDNNLTdaGAAALASAllspniSLLTL 255

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 109107993 224 DLSCNSIE--AFQTASQPQAEF-QLTWLDLRENKL------LHFPDLAAL-PRLIYLNLSNNLI 277
Cdd:cd00116  256 SLSCNDITddGAKDLAEVLAEKeSLLELDLRGNKFgeegaqLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-278 6.40e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.61  E-value: 6.40e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993  38 LGLLQVPLVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEINFLQPGAFQALTHLEHLSLAHNRlamatalsa 117
Cdd:COG4886   37 LLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE--------- 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 118 gGLGPLPRVTSLDLSGNSLYSglLERLLGEAPSLHTLSLAENSLTRLTRhTFRDMPALEQLDLHSNVLMDIeDGAFEGLP 197
Cdd:COG4886  108 -ELSNLTNLESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLT 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 198 HLTHLNLSRNSLTCISD--FSLQQLRVLDLSCNSIEAFqtaSQPQAEF-QLTWLDLRENKLLHFPDLAALPRLIYLNLSN 274
Cdd:COG4886  183 NLKELDLSNNQITDLPEplGNLTNLEELDLSGNQLTDL---PEPLANLtNLETLDLSNNQLTDLPELGNLTNLEELDLSN 259


                 ....
gi 109107993 275 NLIR 278
Cdd:COG4886  260 NQLT 263
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
290-574 5.41e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.91  E-value: 5.41e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 290 IHAPSEGWSALPLSTPNGNVSARPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRSGSLPCLMLLD 369
Cdd:COG4886   23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 370 LSHNALETlelgarALGSLRTLLLQGNALRDLPPyTFANLASLQRLNLQGNRVSPCGGPnepgpascvaFSGIASLRSLS 449
Cdd:COG4886  103 LSGNEELS------NLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEP----------LGNLTNLKSLD 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 450 LVDNEIELLRAGAFLHTPLTELDLSSNPgLEVATGALTGLEaSLEVLALQGNGLTVLQVDLPCFICLKRLNLAENRLSHL 529
Cdd:COG4886  166 LSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 109107993 530 PAWTQAVSLEVLDLRNNSFSLLPGSamGGLeTSLRRLYLQGNPLS 574
Cdd:COG4886  244 PELGNLTNLEELDLSNNQLTDLPPL--ANL-TNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-393 1.31e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 1.31e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993  37 GLGLLQVPLVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEINFLQPGAFQALTHLEHLSLAHNRLAMATALS 116
Cdd:COG4886    9 TLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 117 AGGLGPLPRVTSLDLSGNslysglleRLLGEAPSLHTLSLAENSLTRLTRHtFRDMPALEQLDLHSNVLMDIEDgAFEGL 196
Cdd:COG4886   89 LTDLGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE-PLGNL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 197 PHLTHLNLSRNSLTCISDF--SLQQLRVLDLSCNSIEAFQTA-SQPQaefQLTWLDLRENKLLHFPD-LAALPRLIYLNL 272
Cdd:COG4886  159 TNLKSLDLSNNQLTDLPEElgNLTNLKELDLSNNQITDLPEPlGNLT---NLEELDLSGNQLTDLPEpLANLTNLETLDL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 273 SNNLIrlptgppqdskgihapsegwSALPlstpngnvSARPLSQLLNLDLSYNEIELIPDSFleHLTSLCFLNLSRNCLR 352
Cdd:COG4886  236 SNNQL--------------------TDLP--------ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLT 285

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 109107993 353 TFEARRSGSLPCLMLLDLSHNALETLELGARALGSLRTLLL 393
Cdd:COG4886  286 DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
245-551 6.06e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.36  E-value: 6.06e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 245 LTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSTPNGNVSARPLSQLLNLDLSY 324
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 325 NEIELIPDSFLEHLTSLCFLNLSRNclrtfeaRRSGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPy 404
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 405 TFANLASLQRLNLQGNRVSPCGGPnepgpascvaFSGIASLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPgLEVATG 484
Cdd:COG4886  154 PLGNLTNLKSLDLSNNQLTDLPEE----------LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQ-LTDLPE 222

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 109107993 485 ALTGLEaSLEVLALQGNGLTVLQvDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRNNSFSLL 551
Cdd:COG4886  223 PLANLT-NLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL 287
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 49-476 1.04e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 81.05  E-value: 1.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993  49 PDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEINFLQPGAFQALTHLEHLSLAHNRLamaTALSAGGLGPLPRVTS 128
Cdd:PLN00113 140 PNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQL---VGQIPRELGQMKSLKW 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 129 LDLSGNSLySGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPHLTHLNLSRNS 208
Cdd:PLN00113 217 IYLGYNNL-SGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNS 295

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 209 LTC-ISDF--SLQQLRVLDLSCNSIeafqTASQPQAefqltwldlrenkllhfpdLAALPRLIYLNLSNNliRLPTGPPQ 285
Cdd:PLN00113 296 LSGeIPELviQLQNLEILHLFSNNF----TGKIPVA-------------------LTSLPRLQVLQLWSN--KFSGEIPK 350

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 286 DsKGIHapsEGWSALPLST-------PNGNVSARPLSQL--------------LNLDLSYNEIELIPDSFLEHLTS---- 340
Cdd:PLN00113 351 N-LGKH---NNLTVLDLSTnnltgeiPEGLCSSGNLFKLilfsnslegeipksLGACRSLRRVRLQDNSFSGELPSeftk 426

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 341 ---LCFLNLSRNCLRTFEARRSGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNL 417
Cdd:PLN00113 427 lplVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKL 506

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 109107993 418 QGNRVSpcgG--PNEpgpascvaFSGIASLRSLSLVDNEIELLRAGAFLHTP-LTELDLSSN 476
Cdd:PLN00113 507 SENKLS---GeiPDE--------LSSCKKLVSLDLSHNQLSGQIPASFSEMPvLSQLDLSQN 557
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
199-529 3.99e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.97  E-value: 3.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 199 LTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKllhfpDLAALPRLIYLNLSNNLIr 278
Cdd:COG4886   52 LLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQL- 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 279 lptgppqdskgihapsegwSALPLSTPNgnvsarpLSQLLNLDLSYNEIELIPDSfLEHLTSLCFLNLSRNCLRTFEARr 358
Cdd:COG4886  126 -------------------TDLPEELAN-------LTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEE- 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 359 SGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPyTFANLASLQRLNLQGNRVSpcggpnepgpaSCVA 438
Cdd:COG4886  178 LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLT-----------DLPE 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 439 FSGIASLRSLSLVDNEIELLRAGAFLhTPLTELDLSSNP--GLEVATGALTGLEASLEVLALQGNGLTVLQVDLPCFICL 516
Cdd:COG4886  246 LGNLTNLEELDLSNNQLTDLPPLANL-TNLKTLDLSNNQltDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324

                        330
                 ....*....|...
gi 109107993 517 KRLNLAENRLSHL 529
Cdd:COG4886  325 LLLLLLKGLLVTL 337
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
119-422 4.79e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 72.42  E-value: 4.79e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 119 GLGPLP-----RVTSLDLSGNSLYSgLLERLLGeapSLHTLSLAENSLTRLTRhTFRDmpALEQLDLHSNVLMDIEdgaf 193
Cdd:PRK15370 189 GLTTIPacipeQITTLILDNNELKS-LPENLQG---NIKTLYANSNQLTSIPA-TLPD--TIQEMELSINRITELP---- 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 194 EGLPH-LTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFqtasqPQaefqltwldlrenkllHFPDlaalpRLIYLNL 272
Cdd:PRK15370 258 ERLPSaLQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTL-----PA----------------HLPS-----GITHLNV 311

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 273 -SNNLIRLPTGPPQDSKGIHAPSEGWSALPLSTPngnvsarplSQLLNLDLSYNEIELIPDSFLEHLTSlcfLNLSRNCL 351
Cdd:PRK15370 312 qSNSLTALPETLPPGLKTLEAGENALTSLPASLP---------PELQVLDVSKNQITVLPETLPPTITT---LDVSRNAL 379

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 352 RTFEArrsgSLP-CLMLLDLSHNALetlelgARALGSLRTLLLQG----NALRDLPPYTFANLASLQRL----NLQGNRV 422
Cdd:PRK15370 380 TNLPE----NLPaALQIMQASRNNL------VRLPESLPHFRGEGpqptRIIVEYNPFSERTIQNMQRLmssvGYQGPRV 449
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 199-423 1.15e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.50  E-value: 1.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 199 LTHLNLSRNSLTCISDFSL-QQLRVLDLscnsieafqtasqpqaefqltwldlRENKLLHFPDLAALPRLIYLNLSNNLI 277
Cdd:cd21340    4 ITHLYLNDKNITKIDNLSLcKNLKVLYL-------------------------YDNKITKIENLEFLTNLTHLYLQNNQI 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 278 RlptgppqdskgihapsegwSALPLSTpngnvsarpLSQLLNLDLSYNEIELIpdSFLEHLTSLCFLNLSRNCLR----- 352
Cdd:cd21340   59 E-------------------KIENLEN---------LVNLKKLYLGGNRISVV--EGLENLTNLEELHIENQRLPpgekl 108

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 109107993 353 TFEARRSGSL-PCLMLLDLSHNALETLElGARALGSLRTLLLQGNALRDLPP--YTFANLASLQRLNLQGNRVS 423
Cdd:cd21340  109 TFDPRSLAALsNSLRVLNISGNNIDSLE-PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVC 181
LRR_8 pfam13855
Leucine rich repeat;
149-209 5.82e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 5.82e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 109107993  149 PSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPHLTHLNLSRNSL 209
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
38-296 7.36e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 68.57  E-value: 7.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993  38 LGLLQVPLVLPPDTETLDLSGNQLRSIlasPLGFYTALRHLDLSTNEINFLqPGAFQalTHLEHLSLAHNRLamaTALSA 117
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSL---PENLQGNIKTLYANSNQLTSI-PATLP--DTIQEMELSINRI---TELPE 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 118 gglgPLPR-VTSLDLSGNSLySGLLERLLGEapsLHTLSLAENSLTRLTRHtfrdMPA-LEQLDLHSNVLMDIEdgafEG 195
Cdd:PRK15370 259 ----RLPSaLQSLDLFHNKI-SCLPENLPEE---LRYLSVYDNSIRTLPAH----LPSgITHLNVQSNSLTALP----ET 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 196 LP-HLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPqaefQLTWLDLRENKLLHFPDlaALP-RLIYLNLS 273
Cdd:PRK15370 323 LPpGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPETLPP----TITTLDVSRNALTNLPE--NLPaALQIMQAS 396

                        250       260
                 ....*....|....*....|....
gi 109107993 274 -NNLIRLPTGPPqdskgiHAPSEG 296
Cdd:PRK15370 397 rNNLVRLPESLP------HFRGEG 414
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 52-210 9.88e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.81  E-value: 9.88e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993  52 ETLDLSGNQLRSIlaSPLGFYTALRHLDLSTNEINFLQPgaFQALTHLEHLSLAHNRLAMATalsagGLGPLPRVTSLDL 131
Cdd:cd21340   27 KVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE-----GLENLTNLEELHI 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 132 SGNSLYSGLL-----ERLLGEAPSLHTLSLAENSLTRLTrhTFRDMPALEQLDLHSNVLMDIED--GAFEGLPHLTHLNL 204
Cdd:cd21340   98 ENQRLPPGEKltfdpRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDL 175


                 ....*.
gi 109107993 205 SRNSLT 210
Cdd:cd21340  176 TGNPVC 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 125-574 1.62e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.57  E-value: 1.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 125 RVTSLDLSGNSLySGllerllgeapslhtlslaensltRLTRHTFRdMPALEQLDLHSNVLM-DIEDGAFEGLPHLTHLN 203
Cdd:PLN00113  70 RVVSIDLSGKNI-SG-----------------------KISSAIFR-LPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLN 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 204 LSRNSLT-CISDFSLQQLRVLDLSCNSIeafqTASQPQ---AEFQLTWLDLRENKLL-HFP-DLAALPRLIYLNLSNNli 277
Cdd:PLN00113 125 LSNNNFTgSIPRGSIPNLETLDLSNNML----SGEIPNdigSFSSLKVLDLGGNVLVgKIPnSLTNLTSLEFLTLASN-- 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 278 RLPTGPPQDSKGIHapSEGWSALPLSTPNGNVSAR--PLSQLLNLDLSYNEIE-LIPDSfLEHLTSLCFLNLSRNCLRTF 354
Cdd:PLN00113 199 QLVGQIPRELGQMK--SLKWIYLGYNNLSGEIPYEigGLTSLNHLDLVYNNLTgPIPSS-LGNLKNLQYLFLYQNKLSGP 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 355 EARRSGSLPCLMLLDLSHNAL--ETLELGARaLGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSpcGG-PNEP 431
Cdd:PLN00113 276 IPPSIFSLQKLISLDLSDNSLsgEIPELVIQ-LQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFS--GEiPKNL 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 432 GPAScvafsgiaSLRSLSLVDNEIE------LLRAGAflhtpLTELDLSSNpGLEVATGALTGLEASLEVLALQGNGL-- 503
Cdd:PLN00113 353 GKHN--------NLTVLDLSTNNLTgeipegLCSSGN-----LFKLILFSN-SLEGEIPKSLGACRSLRRVRLQDNSFsg 418

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 504 ------TVLQV--------------------DLPcfiCLKRLNLAENRLS-HLPAWTQAVSLEVLDLRNNSFSLLPGSAM 556
Cdd:PLN00113 419 elpsefTKLPLvyfldisnnnlqgrinsrkwDMP---SLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPRKL 495

                        490
                 ....*....|....*...
gi 109107993 557 GGLeTSLRRLYLQGNPLS 574
Cdd:PLN00113 496 GSL-SELMQLKLSENKLS 512
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
202-551 3.68e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 3.68e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 202 LNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPT 281
Cdd:COG4886    3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 282 GPPQDSKGIHAPSEGWSALPLStpnGNVSARPLSQLLNLDLSYNEIELIPDSfLEHLTSLCFLNLSRNCLRTFEARrSGS 361
Cdd:COG4886   83 SLLLLGLTDLGDLTNLTELDLS---GNEELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEP-LGN 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 362 LPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPyTFANLASLQRLNLQGNRVSpcggpNEPGPascvaFSG 441
Cdd:COG4886  158 LTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLT-----DLPEP-----LAN 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 442 IASLRSLSLVDNEIELLRAGAFLhTPLTELDLSSNPglevatgaLTGLEASLEVLALQgngltvlqvdlpcficlkRLNL 521
Cdd:COG4886  227 LTNLETLDLSNNQLTDLPELGNL-TNLEELDLSNNQ--------LTDLPPLANLTNLK------------------TLDL 279

                        330       340       350
                 ....*....|....*....|....*....|
gi 109107993 522 AENRLSHLPAWTQAVSLEVLDLRNNSFSLL 551
Cdd:COG4886  280 SNNQLTDLKLKELELLLGLNSLLLLLLLLN 309
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 54-253 5.49e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.88  E-value: 5.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993  54 LDLSGNQLRSIlaSPLGFYTALRHLDLSTNEINFLQpgAFQALTHLEHLSLAHNRLamataLSAGGLGPLPRVTSLDLSG 133
Cdd:cd21340    7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQI-----EKIENLENLVNLKKLYLGG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 134 NSLysgllERLLGeapsLHTLSlaenSLTRLTrhtfrdmpaLEQLDLHSNVLMDIEDGAFEGL-PHLTHLNLSRNSLTCI 212
Cdd:cd21340   78 NRI-----SVVEG----LENLT----NLEELH---------IENQRLPPGEKLTFDPRSLAALsNSLRVLNISGNNIDSL 135

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 109107993 213 SDFS-LQQLRVLDLSCNSIEAFQTASQP-QAEFQLTWLDLREN 253
Cdd:cd21340  136 EPLApLRNLEQLDASNNQISDLEELLDLlSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 39-277 4.99e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.94  E-value: 4.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993  39 GLLQVPLVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEINFLQPGAFQALTHLEHLSLAHNRL--AMATALS 116
Cdd:PLN00113 322 GKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLegEIPKSLG 401

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 117 A-------------------GGLGPLPRVTSLDLSGNSLySGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDmPALEQ 177
Cdd:PLN00113 402 AcrslrrvrlqdnsfsgelpSEFTKLPLVYFLDISNNNL-QGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGS-KRLEN 479

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 178 LDLHSNVLMDIEDGAFEGLPHLTHLNLSRNSLT-CISD--FSLQQLRVLDLSCNSIEAFQTASqpQAEFQ-LTWLDLREN 253
Cdd:PLN00113 480 LDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDelSSCKKLVSLDLSHNQLSGQIPAS--FSEMPvLSQLDLSQN 557

                        250       260
                 ....*....|....*....|....*.
gi 109107993 254 KLLHF--PDLAALPRLIYLNLSNNLI 277
Cdd:PLN00113 558 QLSGEipKNLGNVESLVQVNISHNHL 583
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 28-199 2.12e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 60.19  E-value: 2.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993  28 MVDKKVSCQGLGLLQVPLVLPPDTETLDLSGNQLRS----ILASPLGFYTALRHLDLSTNEINFlqPGAFQALTHLEH-- 101
Cdd:COG5238  243 LSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAegaiALAKALQGNTTLTSLDLSVNRIGD--EGAIALAEGLQGnk 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 102 ----LSLAHNRL------AMATALSAGglgplPRVTSLDLSGNSLY---SGLLERLLGEAPSLHTLSLAENSLTRLTRHT 168
Cdd:COG5238  321 tlhtLNLAYNGIgaqgaiALAKALQEN-----TTLHSLDLSDNQIGdegAIALAKYLEGNTTLRELNLGKNNIGKQGAEA 395

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 109107993 169 FRDM---PALEQLDLHSNVL-MDIEDGAFEGLPHL 199
Cdd:COG5238  396 LIDAlqtNRLHTLILDGNLIgAEAQQRLEQLLERI 430
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 36-232 3.56e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 59.42  E-value: 3.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993  36 QGLGLLQVPLVLPPDTETLDLSGNQL----RSILASPLGFYTALRHLDLSTNEINflQPGA---FQALTH---LEHLSLA 105
Cdd:COG5238  195 EGIEELAEALTQNTTVTTLWLKRNPIgdegAEILAEALKGNKSLTTLDLSNNQIG--DEGVialAEALKNnttVETLYLS 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 106 HNRLAMATALS-AGGLGPLPRVTSLDLSGNSL----YSGLLERLLGEAPsLHTLSLAENSLT----RLTRHTFRDMPALE 176
Cdd:COG5238  273 GNQIGAEGAIAlAKALQGNTTLTSLDLSVNRIgdegAIALAEGLQGNKT-LHTLNLAYNGIGaqgaIALAKALQENTTLH 351

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 109107993 177 QLDLHSNVLMDIEDGAF----EGLPHLTHLNLSRNSLT------CISDFSLQQLRVLDLSCNSIEA 232
Cdd:COG5238  352 SLDLSDNQIGDEGAIALakylEGNTTLRELNLGKNNIGkqgaeaLIDALQTNRLHTLILDGNLIGA 417
LRR_8 pfam13855
Leucine rich repeat;
75-136 6.33e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 6.33e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 109107993   75 LRHLDLSTNEINFLQPGAFQALTHLEHLSLAHNRLamaTALSAGGLGPLPRVTSLDLSGNSL 136
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL---TTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 150-277 1.39e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.56  E-value: 1.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 150 SLHTLSLAENSLTRLTRhtFRDMPALEQLDLHSNVLMDIEDgaFEGLPHLTHLNLSRNSLTCISDF-SLQQLRVLDLSCN 228
Cdd:cd21340    3 RITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIENLeNLVNLKKLYLGGN 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 109107993 229 SI---EAFQTAS----------QPQAEFQLTW--------------LDLRENKLLHFPDLAALPRLIYLNLSNNLI 277
Cdd:cd21340   79 RIsvvEGLENLTnleelhienqRLPPGEKLTFdprslaalsnslrvLNISGNNIDSLEPLAPLRNLEQLDASNNQI 154
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 387-552 2.41e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 2.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 387 SLRTLLLQGNALRDLPPytFANLASLQRLNLQGNRVSPCGGpnepgpascvaFSGIASLRSLSLVDNEIELLrAGafLH- 465
Cdd:cd21340   25 NLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN-----------LENLVNLKKLYLGGNRISVV-EG--LEn 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 466 -TPLTELDLS-----SNPGLEVATGALTGLEASLEVLALQGNGLTVLQvDLPCFICLKRLNLAENRLSHLPAWTQAVS-- 537
Cdd:cd21340   89 lTNLEELHIEnqrlpPGEKLTFDPRSLAALSNSLRVLNISGNNIDSLE-PLAPLRNLEQLDASNNQISDLEELLDLLSsw 167

                        170
                 ....*....|....*..
gi 109107993 538 --LEVLDLRNNSFSLLP 552
Cdd:cd21340  168 psLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
173-230 3.44e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 3.44e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 109107993  173 PALEQLDLHSNVLMDIEDGAFEGLPHLTHLNLSRNSLTCISDFSLQ---QLRVLDLSCNSI 230
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSglpSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
31-230 7.66e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 55.86  E-value: 7.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993  31 KKVSCQGLGLLQVPLVLPPDTETLDLSGNQlrsILASPLGFYTALRHLDLSTNEINFLqPGAFQalTHLEHLSLAHNRLa 110
Cdd:PRK15370 223 KTLYANSNQLTSIPATLPDTIQEMELSINR---ITELPERLPSALQSLDLFHNKISCL-PENLP--EELRYLSVYDNSI- 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 111 maTALSAGglgpLPR-VTSLDLSGNSLySGLLERLlgeAPSLHTLSLAENSLTRLTRHTfrdMPALEQLDLHSNVLMDIE 189
Cdd:PRK15370 296 --RTLPAH----LPSgITHLNVQSNSL-TALPETL---PPGLKTLEAGENALTSLPASL---PPELQVLDVSKNQITVLP 362

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 109107993 190 dgafEGL-PHLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSI 230
Cdd:PRK15370 363 ----ETLpPTITTLDVSRNALTNLPENLPAALQIMQASRNNL 400
LRR_8 pfam13855
Leucine rich repeat;
52-109 3.38e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 3.38e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 109107993   52 ETLDLSGNQLRSILASPLGFYTALRHLDLSTNEINFLQPGAFQALTHLEHLSLAHNRL 109
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
315-375 3.41e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 3.41e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 109107993  315 SQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRSGSLPCLMLLDLSHNAL 375
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
365-422 1.01e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 1.01e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 109107993  365 LMLLDLSHNALETLELGA-RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRV 422
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
39-358 5.98e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 49.39  E-value: 5.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993  39 GLLQVPLVLPPDTETLDLSGNQLRSILASPlgfyTALRHLDLSTNEIN---FLQPGafqalthLEHLSLAHNRLAMATAL 115
Cdd:PRK15387 212 GLTTLPDCLPAHITTLVIPDNNLTSLPALP----PELRTLEVSGNQLTslpVLPPG-------LLELSIFSNPLTHLPAL 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 116 SAGglgplprVTSLDLSGNSLYSgllerLLGEAPSLHTLSLAENSLTRLtrhtfrdmPALEQldlhsnvlmdiedgafeg 195
Cdd:PRK15387 281 PSG-------LCKLWIFGNQLTS-----LPVLPPGLQELSVSDNQLASL--------PALPS------------------ 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 196 lpHLTHLNLSRNSLTCISDF--SLQQLRVLDlscnsieaFQTASQPQAEFQLTWLDLRENKLLHFPDL-AALPRLIYlnL 272
Cdd:PRK15387 323 --ELCKLWAYNNQLTSLPTLpsGLQELSVSD--------NQLASLPTLPSELYKLWAYNNRLTSLPALpSGLKELIV--S 390

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 273 SNNLIRLPTgPPQDSKGIHAPSEGWSALPLsTPNGnvsarplsqLLNLDLSYNEIELIPDSFLeHLTSLCFLNLSRNCL- 351
Cdd:PRK15387 391 GNRLTSLPV-LPSELKELMVSGNRLTSLPM-LPSG---------LLSLSVYRNQLTRLPESLI-HLSSETTVNLEGNPLs 458


                 ....*...
gi 109107993 352 -RTFEARR 358
Cdd:PRK15387 459 eRTLQALR 466
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
296-573 7.79e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 49.31  E-value: 7.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 296 GWSALPLSTPngnvsarplSQLLNLDLSYNEIELIPDSFLEHLTSLcflNLSRNCLRTFEArrsgSLP-CLMLLDLSHNA 374
Cdd:PRK15370 189 GLTTIPACIP---------EQITTLILDNNELKSLPENLQGNIKTL---YANSNQLTSIPA----TLPdTIQEMELSINR 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 375 LetLELGARALGSLRTLLLQGNALRDLPPytfanlaslqrlNLqgnrvspcggPNEpgpascvafsgiasLRSLSLVDNE 454
Cdd:PRK15370 253 I--TELPERLPSALQSLDLFHNKISCLPE------------NL----------PEE--------------LRYLSVYDNS 294

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 455 IELLRAgaflHTPlteldlssnpglevatgaltgleASLEVLALQGNGLTVLQVDLPcfICLKRLNLAENRLSHLPAwTQ 534
Cdd:PRK15370 295 IRTLPA----HLP-----------------------SGITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPA-SL 344

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 109107993 535 AVSLEVLDLRNNSFSLLPGSamggLETSLRRLYLQGNPL 573
Cdd:PRK15370 345 PPELQVLDVSKNQITVLPET----LPPTITTLDVSRNAL 379
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 361-577 1.52e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 47.35  E-value: 1.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 361 SLPCLMLLDLSHNALEtlELGARALG-------SLRTLLLQGNALRDLPPYT------FANLASLQRLNLQGNRVSPcgg 427
Cdd:cd00116   21 KLLCLQVLRLEGNTLG--EEAAKALAsalrpqpSLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLSDNALGP--- 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 428 pnePGPASCVAFSGIASLRSLSLVDNEIELlRAGAFLHT-------PLTELDLS----SNPGLEVATGALTGLeASLEVL 496
Cdd:cd00116   96 ---DGCGVLESLLRSSSLQELKLNNNGLGD-RGLRLLAKglkdlppALEKLVLGrnrlEGASCEALAKALRAN-RDLKEL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 497 -----ALQGNGLTVLQVDLPCFICLKRLNLAENRLSHL------PAWTQAVSLEVLDLRNNSFSLLP----GSAMGGLET 561
Cdd:cd00116  171 nlannGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEgasalaETLASLKSLEVLNLGDNNLTDAGaaalASALLSPNI 250

                        250
                 ....*....|....*.
gi 109107993 562 SLRRLYLQGNPLSCCG 577
Cdd:cd00116  251 SLLTLSLSCNDITDDG 266
LRRNT smart00013
Leucine rich repeat N-terminal domain;
21-52 2.09e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.53  E-value: 2.09e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 109107993    21 QDKVACKMVDKKVSCQGLGLLQVPLVLPPDTE 52
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 100-386 2.46e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.09  E-value: 2.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 100 EHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERL---LGEAPSLHTLSLAENSLTRLTRHTFRDM---- 172
Cdd:COG5238  156 VHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELaeaLTQNTTVTTLWLKRNPIGDEGAEILAEAlkgn 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 173 PALEQLDLHSNvlmDIEDGAFEGLphLTHLNLSRnsltcisdfslqQLRVLDLSCNSIE---AFQTASQPQAEFQLTWLD 249
Cdd:COG5238  236 KSLTTLDLSNN---QIGDEGVIAL--AEALKNNT------------TVETLYLSGNQIGaegAIALAKALQGNTTLTSLD 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 250 LRENKLlHFPDLAAL-------PRLIYLNLSNNLIRlptgppqdskgihapSEGWSALplstpngnVSAR-PLSQLLNLD 321
Cdd:COG5238  299 LSVNRI-GDEGAIALaeglqgnKTLHTLNLAYNGIG---------------AQGAIAL--------AKALqENTTLHSLD 354

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 109107993 322 LSYNEI------ELIpdSFLEHLTSLCFLNLSRNCLrtfearrsGSLPCLMLLD-LSHNALETLELGARALG 386
Cdd:COG5238  355 LSDNQIgdegaiALA--KYLEGNTTLRELNLGKNNI--------GKQGAEALIDaLQTNRLHTLILDGNLIG 416
LRR_8 pfam13855
Leucine rich repeat;
387-455 2.58e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 2.58e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 109107993  387 SLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNR---VSPcggpnepgpascVAFSGIASLRSLSLVDNEI 455
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLlttLSP------------GAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
516-573 5.09e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 5.09e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993  516 LKRLNLAENRLSHLP--AWTQAVSLEVLDLRNNSFSLLPGSAMGGLeTSLRRLYLQGNPL 573
Cdd:pfam13855   3 LRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 52-135 6.98e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 45.96  E-value: 6.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993  52 ETLDLSGNQLRSILASPLGFYTALRHLDLSTNEINFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLgPLPRvTSLDL 131
Cdd:PLN03150 445 QSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGGR-LLHR-ASFNF 522


                 ....
gi 109107993 132 SGNS 135
Cdd:PLN03150 523 TDNA 526
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 310-549 9.15e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.04  E-value: 9.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 310 SARPLSQLLNLDLSYNEIELIPD------SFLEHLTSLCFLNLSRNCL-----RTFEARRSGSlpCLMLLDLSHNALET- 377
Cdd:cd00116   46 ALRPQPSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDNALgpdgcGVLESLLRSS--SLQELKLNNNGLGDr 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 378 -LELGARALGS----LRTLLLQGNALRDLPPYTFANLA----SLQRLNLQGNRVspcggpNEPG-PASCVAFSGIASLRS 447
Cdd:cd00116  124 gLRLLAKGLKDlppaLEKLVLGRNRLEGASCEALAKALranrDLKELNLANNGI------GDAGiRALAEGLKANCNLEV 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 448 LSLVDNEIELLRAGAFLHTP-----LTELDLSSNPGLEVatGALTGLEASLEVLalqgngltvlqvdlpcfICLKRLNLA 522
Cdd:cd00116  198 LDLNNNGLTDEGASALAETLaslksLEVLNLGDNNLTDA--GAAALASALLSPN-----------------ISLLTLSLS 258

                        250       260       270
                 ....*....|....*....|....*....|...
gi 109107993 523 ENRLSHLPAWTQA------VSLEVLDLRNNSFS 549
Cdd:cd00116  259 CNDITDDGAKDLAevlaekESLLELDLRGNKFG 291
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 54-179 1.33e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.62  E-value: 1.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993  54 LDLSGNQLRSIlaSPLGFYTALRHLDLSTNEINFLQpgAFQALTHLEHLSLAHNRLA----------MATALSA------ 117
Cdd:cd21340   51 LYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPpgekltfdprSLAALSNslrvln 126

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 109107993 118 ---------GGLGPLPRVTSLDLSGNSLYSGL-LERLLGEAPSLHTLSLAENSLTRLTRhtFRD-----MPALEQLD 179
Cdd:cd21340  127 isgnnidslEPLAPLRNLEQLDASNNQISDLEeLLDLLSSWPSLRELDLTGNPVCKKPK--YRDkiilaSKSLEVLD 201
PLN03150 PLN03150
hypothetical protein; Provisional
 330-423 1.52e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.81  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 330 IPD--SFLEHLTSLcflNLSRNCLRTFEARRSGSLPCLMLLDLSHNALEtlelgaralGSLrtlllqgnalrdlpPYTFA 407
Cdd:PLN03150 434 IPNdiSKLRHLQSI---NLSGNSIRGNIPPSLGSITSLEVLDLSYNSFN---------GSI--------------PESLG 487

                         90
                 ....*....|....*.
gi 109107993 408 NLASLQRLNLQGNRVS 423
Cdd:PLN03150 488 QLTSLRILNLNGNSLS 503
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 21-48 2.84e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 38.38  E-value: 2.84e-04
                          10        20
                  ....*....|....*....|....*...
gi 109107993   21 QDKVACKMVDKKVSCQGLGLLQVPLVLP 48
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
PLN03150 PLN03150
hypothetical protein; Provisional
 496-574 3.25e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.04  E-value: 3.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 496 LALQGNGLT-VLQVDLPCFICLKRLNLAENRLSHL--PAWTQAVSLEVLDLRNNSFS-LLPGSAmgGLETSLRRLYLQGN 571
Cdd:PLN03150 423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRGNipPSLGSITSLEVLDLSYNSFNgSIPESL--GQLTSLRILNLNGN 500


                 ...
gi 109107993 572 PLS 574
Cdd:PLN03150 501 SLS 503
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 215-476 4.03e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.11  E-value: 4.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 215 FSLQQLRVLDLSCNSI---EAFQTASQPQAEFQLTWLDLRENKLLHFPD--------LAALPRLIYLNLSNNLIrLPTGP 283
Cdd:cd00116   20 PKLLCLQVLRLEGNTLgeeAAKALASALRPQPSLKELCLSLNETGRIPRglqsllqgLTKGCGLQELDLSDNAL-GPDGC 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 284 PqdskgihapseGWSALPLSTPngnvsarplsqLLNLDLSYNEIE-----LIPDSFLEHLTSLCFLNLSRNCLRTFEARR 358
Cdd:cd00116   99 G-----------VLESLLRSSS-----------LQELKLNNNGLGdrglrLLAKGLKDLPPALEKLVLGRNRLEGASCEA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 359 SGSL----PCLMLLDLSHNAL-----ETLELGARALGSLRTLLLQGNALRDLP----PYTFANLASLQRLNLQGNRVSpc 425
Cdd:cd00116  157 LAKAlranRDLKELNLANNGIgdagiRALAEGLKANCNLEVLDLNNNGLTDEGasalAETLASLKSLEVLNLGDNNLT-- 234

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 109107993 426 ggpNEPGPASCVAF-SGIASLRSLSLVDNEIELLRAGAFLH-----TPLTELDLSSN 476
Cdd:cd00116  235 ---DAGAAALASALlSPNISLLTLSLSCNDITDDGAKDLAEvlaekESLLELDLRGN 288
PLN03150 PLN03150
hypothetical protein; Provisional
 54-152 8.71e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.50  E-value: 8.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993  54 LDLSGNQLRSILASPLgfyTALRHL---DLSTNEINFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRvtsLD 130
Cdd:PLN03150 423 LGLDNQGLRGFIPNDI---SKLRHLqsiNLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRI---LN 496

                         90       100
                 ....*....|....*....|..
gi 109107993 131 LSGNSLySGLLERLLGEAPsLH 152
Cdd:PLN03150 497 LNGNSL-SGRVPAALGGRL-LH 516
PLN03150 PLN03150
hypothetical protein; Provisional
 260-363 1.23e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.11  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109107993 260 DLAALPRLIYLNLSNNLIRlptgppqdskgihapsegwSALPLSTpnGNVSArplsqLLNLDLSYNEIE-LIPDSfLEHL 338
Cdd:PLN03150 437 DISKLRHLQSINLSGNSIR-------------------GNIPPSL--GSITS-----LEVLDLSYNSFNgSIPES-LGQL 489

                         90       100
                 ....*....|....*....|....*
gi 109107993 339 TSLCFLNLSRNCLrtfearrSGSLP 363
Cdd:PLN03150 490 TSLRILNLNGNSL-------SGRVP 507
LRR_8 pfam13855
Leucine rich repeat;
197-255 2.60e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 2.60e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 109107993  197 PHLTHLNLSRNSLTCISD---FSLQQLRVLDLSCNSIEAFqtasqPQAEFQ----LTWLDLRENKL 255
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgafKGLSNLKVLDLSNNLLTTL-----SPGAFSglpsLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH