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Conserved domains on  [gi|1622944739|ref|XP_001082072|]
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DNA excision repair protein ERCC-8 isoform X1 [Macaca mulatta]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 40-361 1.42e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 132.07  E-value: 1.42e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739  40 RIHGGGINTLDIEPVeGRYMLSGGSDGVIVLYDLENSSRQSYYTckavcsigrdhpdVHRYSVETVQWYPHDTGMFtSSS 119
Cdd:cd00200     6 KGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLK-------------GHTGPVRDVAASADGTYLA-SGS 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 120 FDKTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRH 198
Cdd:cd00200    71 SDKTIRLWDLETGECVRTLTgHTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 199 DYIlATASADSRVKLWDVRRASgCLITLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE 278
Cdd:cd00200   148 TFV-ASSSQDGTIKLWDLRTGK-CVATL---------------TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 279 NTLVNYGKvcNNSKKGLKFTVS----CGCSSEfvfvpygSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSR 354
Cdd:cd00200   211 CLGTLRGH--ENGVNSVAFSPDgyllASGSED-------GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA 281


                  ....*..
gi 1622944739 355 DCNILAW 361
Cdd:cd00200   282 DGTIRIW 288
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 40-361 1.42e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 132.07  E-value: 1.42e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739  40 RIHGGGINTLDIEPVeGRYMLSGGSDGVIVLYDLENSSRQSYYTckavcsigrdhpdVHRYSVETVQWYPHDTGMFtSSS 119
Cdd:cd00200     6 KGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLK-------------GHTGPVRDVAASADGTYLA-SGS 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 120 FDKTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRH 198
Cdd:cd00200    71 SDKTIRLWDLETGECVRTLTgHTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 199 DYIlATASADSRVKLWDVRRASgCLITLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE 278
Cdd:cd00200   148 TFV-ASSSQDGTIKLWDLRTGK-CVATL---------------TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 279 NTLVNYGKvcNNSKKGLKFTVS----CGCSSEfvfvpygSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSR 354
Cdd:cd00200   211 CLGTLRGH--ENGVNSVAFSPDgyllASGSED-------GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA 281


                  ....*..
gi 1622944739 355 DCNILAW 361
Cdd:cd00200   282 DGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
16-361 2.41e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.27  E-value: 2.41e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739  16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPvEGRYMLSGGSDGVIVLYDLENSSRQSyytckavcsigrdHP 95
Cdd:COG2319    51 LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLR-------------TL 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739  96 DVHRYSVETVQWYPhDTGMFTSSSFDKTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLK 174
Cdd:COG2319   117 TGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGK---LLASGSDDGTVRLWDLA 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 175 SGSCSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWDVRRASgCLITLdqhngkksqavesanTAHNGKVNGLCFT 254
Cdd:COG2319   193 TGKLLRTLTGHTGAVRSVAFSPDGKL-LASGSADGTVRLWDLATGK-LLRTL---------------TGHSGSVRSVAFS 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 255 SDGLHLLTVGTDNRMRLWNSSNGEntlvnygkvCNNSKKGLKFTVSCgcsseFVFVPYGSTIA---------VYTVYSGE 325
Cdd:COG2319   256 PDGRLLASGSADGTVRLWDLATGE---------LLRTLTGHSGGVNS-----VAFSPDGKLLAsgsddgtvrLWDLATGK 321

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1622944739 326 QITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361
Cdd:COG2319   322 LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 175-215 9.63e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 9.63e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1622944739  175 SGSCSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWD 215
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
176-215 1.83e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 1.83e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622944739 176 GSCSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWD 215
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 172-282 4.32e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.79  E-value: 4.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 172 DLKSGSCshILQGHRQEILAVSWSPRHDYILATASADSRVKLWDV---RRA---------------------SGCLITLD 227
Cdd:PTZ00420  113 EIKDPQC--ILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIeneKRAfqinmpkklsslkwnikgnllSGTCVGKH 190

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622944739 228 QH-NGKKSQAVESANTAHNGKVNGLCFTSDGL-----HLLTVG-TDNRMR---LWNSSNGENTLV 282
Cdd:PTZ00420  191 MHiIDPRKQEIASSFHIHDGGKNTKNIWIDGLggddnYILSTGfSKNNMRemkLWDLKNTTSALV 255
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 40-361 1.42e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 132.07  E-value: 1.42e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739  40 RIHGGGINTLDIEPVeGRYMLSGGSDGVIVLYDLENSSRQSYYTckavcsigrdhpdVHRYSVETVQWYPHDTGMFtSSS 119
Cdd:cd00200     6 KGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLK-------------GHTGPVRDVAASADGTYLA-SGS 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 120 FDKTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRH 198
Cdd:cd00200    71 SDKTIRLWDLETGECVRTLTgHTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 199 DYIlATASADSRVKLWDVRRASgCLITLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE 278
Cdd:cd00200   148 TFV-ASSSQDGTIKLWDLRTGK-CVATL---------------TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 279 NTLVNYGKvcNNSKKGLKFTVS----CGCSSEfvfvpygSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSR 354
Cdd:cd00200   211 CLGTLRGH--ENGVNSVAFSPDgyllASGSED-------GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA 281


                  ....*..
gi 1622944739 355 DCNILAW 361
Cdd:cd00200   282 DGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
16-361 2.41e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.27  E-value: 2.41e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739  16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPvEGRYMLSGGSDGVIVLYDLENSSRQSyytckavcsigrdHP 95
Cdd:COG2319    51 LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLR-------------TL 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739  96 DVHRYSVETVQWYPhDTGMFTSSSFDKTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLK 174
Cdd:COG2319   117 TGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGK---LLASGSDDGTVRLWDLA 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 175 SGSCSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWDVRRASgCLITLdqhngkksqavesanTAHNGKVNGLCFT 254
Cdd:COG2319   193 TGKLLRTLTGHTGAVRSVAFSPDGKL-LASGSADGTVRLWDLATGK-LLRTL---------------TGHSGSVRSVAFS 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 255 SDGLHLLTVGTDNRMRLWNSSNGEntlvnygkvCNNSKKGLKFTVSCgcsseFVFVPYGSTIA---------VYTVYSGE 325
Cdd:COG2319   256 PDGRLLASGSADGTVRLWDLATGE---------LLRTLTGHSGGVNS-----VAFSPDGKLLAsgsddgtvrLWDLATGK 321

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1622944739 326 QITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361
Cdd:COG2319   322 LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
14-361 3.40e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.88  E-value: 3.40e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739  14 DPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPvEGRYMLSGGSDGVIVLYDLEnssrqsyyTCKAVCSIGRd 93
Cdd:COG2319    91 RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLA--------TGKLLRTLTG- 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739  94 hpdvHRYSVETVQWYPhDTGMFTSSSFDKTLKVWDTNTLQTADVFnfeetvySHHMSPV-----STKHCLVAVGTRGPKV 168
Cdd:COG2319   161 ----HSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL-------TGHTGAVrsvafSPDGKLLASGSADGTV 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 169 QLCDLKSGSCSHILQGHRQEILAVSWSPrHDYILATASADSRVKLWDVRRASgCLITLdqhngkksqavesanTAHNGKV 248
Cdd:COG2319   229 RLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGE-LLRTL---------------TGHSGGV 291

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 249 NGLCFTSDGLHLLTVGTDNRMRLWNSSNGE--NTLvnygkvcnnskKGLKFTVSCgcsseFVFVPYGSTIA--------- 317
Cdd:COG2319   292 NSVAFSPDGKLLASGSDDGTVRLWDLATGKllRTL-----------TGHTGAVRS-----VAFSPDGKTLAsgsddgtvr 355

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1622944739 318 VYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361
Cdd:COG2319   356 LWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
42-273 5.95e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 119.25  E-value: 5.95e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739  42 HGGGINTLDIEPvEGRYMLSGGSDGVIVLYDLEnssrqsyyTCKAVCSIGRdhpdvHRYSVETVQWYPhDTGMFTSSSFD 121
Cdd:COG2319   203 HTGAVRSVAFSP-DGKLLASGSADGTVRLWDLA--------TGKLLRTLTG-----HSGSVRSVAFSP-DGRLLASGSAD 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 122 KTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRHDY 200
Cdd:COG2319   268 GTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGK---LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKT 344

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622944739 201 iLATASADSRVKLWDVRrASGCLITLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273
Cdd:COG2319   345 -LASGSDDGTVRLWDLA-TGELLRTL---------------TGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 42-273 9.95e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.89  E-value: 9.95e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739  42 HGGGINTLDIEPvEGRYMLSGGSDGVIVLYDLENssrqsyYTCKAVCsigRDHPDvhrySVETVQWyPHDTGMFTSSSFD 121
Cdd:cd00200    92 HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVET------GKCLTTL---RGHTD----WVNSVAF-SPDGTFVASSSQD 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 122 KTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTKHClvaVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPrHDY 200
Cdd:cd00200   157 GTIKLWDLRTGKCVATLTgHTGEVNSVAFSPDGEKLL---SSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGY 232

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622944739 201 ILATASADSRVKLWDVRRASgCLITLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273
Cdd:cd00200   233 LLASGSEDGTIRVWDLRTGE-CVQTL---------------SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
98-361 1.14e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.83  E-value: 1.14e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739  98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGS 177
Cdd:COG2319    35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR---LLASASADGTVRLWDLATGL 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 178 CSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWDVrrASG-CLITLdqhngkksqavesanTAHNGKVNGLCFTSD 256
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSPDGKT-LASGSADGTVRLWDL--ATGkLLRTL---------------TGHSGAVTSVAFSPD 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 257 GLHLLTVGTDNRMRLWNSSNGE--NTLvnygkvcnnskKGLKFTVSCgcsseFVFVPYGSTIA---------VYTVYSGE 325
Cdd:COG2319   174 GKLLASGSDDGTVRLWDLATGKllRTL-----------TGHTGAVRS-----VAFSPDGKLLAsgsadgtvrLWDLATGK 237

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1622944739 326 QITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361
Cdd:COG2319   238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
42-217 1.14e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.67  E-value: 1.14e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739  42 HGGGINTLDIEPvEGRYMLSGGSDGVIVLYDLENSSRQSYYTckavcsigrdhpdVHRYSVETVQWYPhDTGMFTSSSFD 121
Cdd:COG2319   245 HSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLT-------------GHSGGVNSVAFSP-DGKLLASGSDD 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 122 KTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRHDY 200
Cdd:COG2319   310 GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGK---TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRT 386

                         170
                  ....*....|....*..
gi 1622944739 201 iLATASADSRVKLWDVR 217
Cdd:COG2319   387 -LASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 178-361 8.94e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.07  E-value: 8.94e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 178 CSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWDVrrasgclitldqhngkKSQAVESANTAHNGKVNGLCFTSDG 257
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDL----------------ETGELLRTLKGHTGPVRDVAASADG 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 258 LHLLTVGTDNRMRLWNSSNGEntlvnygkvCNNSKKGLKFTVSCgcsseFVFVPYGS---------TIAVYTVYSGEQIT 328
Cdd:cd00200    64 TYLASGSSDKTIRLWDLETGE---------CVRTLTGHTSYVSS-----VAFSPDGRilssssrdkTIKVWDVETGKCLT 129

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1622944739 329 MLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361
Cdd:cd00200   130 TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 175-215 9.63e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 9.63e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1622944739  175 SGSCSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWD 215
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
176-215 1.83e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 1.83e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622944739 176 GSCSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWD 215
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 172-282 4.32e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.79  E-value: 4.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 172 DLKSGSCshILQGHRQEILAVSWSPRHDYILATASADSRVKLWDV---RRA---------------------SGCLITLD 227
Cdd:PTZ00420  113 EIKDPQC--ILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIeneKRAfqinmpkklsslkwnikgnllSGTCVGKH 190

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622944739 228 QH-NGKKSQAVESANTAHNGKVNGLCFTSDGL-----HLLTVG-TDNRMR---LWNSSNGENTLV 282
Cdd:PTZ00420  191 MHiIDPRKQEIASSFHIHDGGKNTKNIWIDGLggddnYILSTGfSKNNMRemkLWDLKNTTSALV 255
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 82-275 1.13e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.39  E-value: 1.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739  82 YTCKAVCSIGRD--HPDVH---RYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQ-TADVFNFEETVYSHHMSpvSTK 155
Cdd:PLN00181  510 FECESIIKDGRDihYPVVElasRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQlVTEMKEHEKRVWSIDYS--SAD 587

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 156 HCLVAVGTRGPKVQLCDLKSGSCSHILQGhRQEILAVSWSPRHDYILATASADSRVKLWDVRRASGCLITLdqhngkksq 235
Cdd:PLN00181  588 PTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTM--------- 657

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1622944739 236 avesanTAHNGKVNGLCFTsDGLHLLTVGTDNRMRLWNSS 275
Cdd:PLN00181  658 ------IGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLS 690
WD40 COG2319
WD40 repeat [General function prediction only];
42-131 6.76e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.52  E-value: 6.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739  42 HGGGINTLDIEPvEGRYMLSGGSDGVIVLYDLENSSRQSYYTckavcsigrdhpdVHRYSVETVQWYPhDTGMFTSSSFD 121
Cdd:COG2319   329 HTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLT-------------GHTGAVTSVAFSP-DGRTLASGSAD 393

                          90
                  ....*....|
gi 1622944739 122 KTLKVWDTNT 131
Cdd:COG2319   394 GTVRLWDLAT 403
PTZ00421 PTZ00421
coronin; Provisional
 173-277 1.71e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 43.73  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 173 LKSGSCSHI--LQGHRQEILAVSWSPRHDYILATASADSRVKLWDVRRasgclitldqhnGKKSQAVESantaHNGKVNG 250
Cdd:PTZ00421  110 LTQNISDPIvhLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER------------GKAVEVIKC----HSDQITS 173

                          90       100
                  ....*....|....*....|....*..
gi 1622944739 251 LCFTSDGLHLLTVGTDNRMRLWNSSNG 277
Cdd:PTZ00421  174 LEWNLDGSLLCTTSKDKKLNIIDPRDG 200
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 242-273 4.05e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 4.05e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1622944739  242 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 192-278 1.70e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.26  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944739 192 VSWSPRHDyILATASADSRVklwDVRRASGclitldqhngkksQAVESANT-AHNGKVNGLCFTSDGlHLLTVGT-DNRM 269
Cdd:pfam12894   1 MSWCPTMD-LIALATEDGEL---LLHRLNW-------------QRVWTLSPdKEDLEVTSLAWRPDG-KLLAVGYsDGTV 62


                  ....*....
gi 1622944739 270 RLWNSSNGE 278
Cdd:pfam12894  63 RLLDAENGK 71
WD40 pfam00400
WD domain, G-beta repeat;
242-273 3.22e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 3.22e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1622944739 242 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 323-361 5.14e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 5.14e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1622944739  323 SGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
324-361 5.75e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 5.75e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1622944739 324 GEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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