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Conserved domains on  [gi|2796929195|gb|XFE25564|]
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helix-turn-helix domain-containing protein [Streptococcus pneumoniae]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 11443570)

helix-turn-helix domain-containing protein such as an XRE (Xenobiotic Response Element) family transcriptional regulator

Gene Ontology:  GO:0003677
PubMed:  37972151

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
8-49 5.02e-10

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


:

Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 49.22  E-value: 5.02e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 2796929195  8 DVGKRIKELRISSNLTQDKIAEYLSLNQSMIAKMEKGERNIT 49
Cdd:COG1396    7 ALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPS 48
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
8-49 5.02e-10

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 49.22  E-value: 5.02e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 2796929195  8 DVGKRIKELRISSNLTQDKIAEYLSLNQSMIAKMEKGERNIT 49
Cdd:COG1396    7 ALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPS 48
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 10-49 1.00e-08

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 45.24  E-value: 1.00e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 2796929195 10 GKRIKELRISSNLTQDKIAEYLSLNQSMIAKMEKGERNIT 49
Cdd:cd00093    1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPS 40
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
12-49 1.51e-07

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 42.51  E-value: 1.51e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2796929195  12 RIKELRISSNLTQDKIAEYLSLNQSMIAKMEKGERNIT 49
Cdd:smart00530  1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPS 38
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 13-49 2.17e-06

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 39.45  E-value: 2.17e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 2796929195 13 IKELRISSNLTQDKIAEYLSLNQSMIAKMEKGERNIT 49
Cdd:pfam01381  1 LKELREELGLSQEELAEKLGVSRSTISKIENGKREPS 37
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
8-49 5.02e-10

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 49.22  E-value: 5.02e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 2796929195  8 DVGKRIKELRISSNLTQDKIAEYLSLNQSMIAKMEKGERNIT 49
Cdd:COG1396    7 ALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPS 48
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 10-49 1.00e-08

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 45.24  E-value: 1.00e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 2796929195 10 GKRIKELRISSNLTQDKIAEYLSLNQSMIAKMEKGERNIT 49
Cdd:cd00093    1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPS 40
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 6-49 4.62e-08

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 44.16  E-value: 4.62e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 2796929195  6 VCDVGKRIKELRISSNLTQDKIAEYLSLNQSMIAKMEKGERNIT 49
Cdd:COG1813   10 VEDYGERIREAREARGLSQEELAEKLGVSESTIRRIERGEATPS 53
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
12-49 1.51e-07

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 42.51  E-value: 1.51e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2796929195  12 RIKELRISSNLTQDKIAEYLSLNQSMIAKMEKGERNIT 49
Cdd:smart00530  1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPS 38
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
1-49 4.33e-07

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 41.37  E-value: 4.33e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 2796929195  1 MNMInvcdVGKRIKELRISSNLTQDKIAEYLSLNQSMIAKMEKGERNIT 49
Cdd:COG1476    1 MKKK----LGNRLKELRKERGLTQEELAELLGVSRQTISAIENGKYNPS 45
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 13-49 2.17e-06

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 39.45  E-value: 2.17e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 2796929195 13 IKELRISSNLTQDKIAEYLSLNQSMIAKMEKGERNIT 49
Cdd:pfam01381  1 LKELREELGLSQEELAEKLGVSRSTISKIENGKREPS 37
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 10-49 5.33e-06

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 38.81  E-value: 5.33e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 2796929195 10 GKRIKELRISSNLTQDKIAEYLSLNQSMIAKMEKGERNIT 49
Cdd:pfam12844  1 GERLRKAREERGLTQEELAERLGISRSQLSAIENGKSVPP 40
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 9-49 7.77e-06

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 38.85  E-value: 7.77e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 2796929195  9 VGKRIKELRISSNLTQDKIAEYLSLNQSMIAKMEKGERNIT 49
Cdd:COG3620   18 LGEALRLMRKELGLSQLPVAELVGVSQSDILRIESGKRDPT 58
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 9-47 1.70e-05

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 37.48  E-value: 1.70e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 2796929195  9 VGKRIKELRISSNLTQDKIAEYLSLNQSMIAKMEKGERN 47
Cdd:COG1426    6 IGELLRQAREAKGLSLEDVAERTKISVSYLEAIEEGDFD 44
YiaG COG2944
DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];
10-49 2.68e-05

DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];


Pssm-ID: 442187 [Multi-domain]  Cd Length: 64  Bit Score: 36.84  E-value: 2.68e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 2796929195 10 GKRIKELRISSNLTQDKIAEYLSLNQSMIAKMEKGERNIT 49
Cdd:COG2944    8 PEEIRALRERLGLSQAEFAALLGVSVSTVRRWEQGRRKPS 47
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 8-46 3.15e-03

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 31.73  E-value: 3.15e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 2796929195  8 DVGKRIKELRISSNLTQDKIAEYLSLNQSMIAKMEKGER 46
Cdd:pfam13560  1 ELGARLRRLRERAGLSQEALARRLGVSRSTLSRLETGRR 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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