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Conserved domains on  [gi|2796580527|ref|WP_373247590|]
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PD-(D/E)XK nuclease family protein [Parabacteroides distasonis]

Protein Classification

PD-(D/E)XK nuclease family protein( domain architecture ID 11467507)

PD-(D/E)XK nuclease family protein similar to ATP-dependent helicase/deoxyribonuclease subunit B (AddB), part of a heterodimer that acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AddB COG3857
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];
117-958 2.65e-71

ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];


:

Pssm-ID: 443066 [Multi-domain]  Cd Length: 1019  Bit Score: 255.83  E-value: 2.65e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  117 RMLFSNVtdLREIENDFDFLSDEQ-----IAAIRSFWSSFYPRGDTPNQ-QQFLAVW----QVLYDLYEEFRATLAAEGK 186
Cdd:COG3857     87 RMLLRKI--LEEHKDELKVFARAAdkpgfIEQLAELITELKRYGITPEDlEEAAELLkeklRDLALIYEAYEEKLAGRYI 164
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  187 GYEgMIFREVVESMErgESPDLPYEQIVFVGLNALSVSEEHFLAQLQKR----------EIADFYWDYVSDKV------- 249
Cdd:COG3857    165 DSE-DLLRLLAEKLE--KSEFLEGAEIYIDGFTDFTPQELELLEALLKKakevtitltlDPDELDLFSATGETyerllel 241
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  250 -TDPDNKASYFVSRNLKSFPSSMKLPPEEKVKTEIEVIGIPSGIGQAKHVYTLLSDWCKEAEMSSEEalrTAVILPDEHL 328
Cdd:COG3857    242 aKENGVEVEFKKSPELAHLERNLFAYPPEEEPEGIEIIEAANRRAEVEAVAREIRRLVREEGYRYRD---IAVVVRDLEA 318
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  329 LIPVLNAIPEQIR-RINVTMGYPLAGTPvasLIEYILALqknVRYIDRNplFYFRDVLPVLNHRYILSTSPEIISSLVKE 407
Cdd:COG3857    319 YAPLIERVFAEYGiPYFIDEKRPLSHHP---LVELILSL---LELVRSN--FRYEDVFRLLKTGLLRPLSREEIDRLENY 390
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  408 ITENN-------------KIYISHTELEKTPLLEILFTPVTG--------------VEAFSDYLIKVLEELNKVMSALSD 460
Cdd:COG3857    391 VLAYGirgrrwleryleeEEELTDEEEEDLERLNELRDRLLEpllplrerlkkaktVREWAEALYEFLEELGVPEKLEEW 470
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  461 EEEEDAPQRTNDLEQEFIFHYFTTV-NRMKEVMKDAriEMKIDTFFRLLKRVTDTITIPFHGEPLSGLQIMGVLETRALD 539
Cdd:COG3857    471 REAEEAGDLEEAREHEQAWNALIELlDELVEVLGDE--KLSLEEFLRILESGLEELTFGLIPPSLDQVQVGGLDRARGLD 548
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  540 FDRLIILSMNEGIFPQRKAANSFIPYNLRR-----GFGL-PTYEHQDSVWAYHFYRLIERAS-HVSLLYDTRSNGLQTGE 612
Cdd:COG3857    549 FKAVFVLGLNEGVFPARPREDGLLSDEERErlnelGLELpPTSRERLLEERFLFYRALTRASeRLYLSYPLADEEGKALL 628
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  613 VSRFVHQLHYHYEVPMRDKLVVYNVSSSKTP-------PLAVPKREDVMRRLDAYRkgGSKAISASAINTYLDCPLKFYF 685
Cdd:COG3857    629 PSPLIDRLRELFPELEERSLLEEELEYIGTPesalselAAALRQLELAPLWWDVYK--WLLKLSVSRLETYAACPFQFFL 706
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  686 SVVEGIReeEEVSETIESDVFGSILHKVMEELYKPFQGKMVTVDLLKAIRKDtALLTGAIARAFASEFFKtevVRSLTGQ 765
Cdd:COG3857    707 RYGLKLK--EREEYELDAPDRGTLFHAVLERFYKELKEEGLDWADLSDEELE-ELLEEAVEELAPELQNG---ILLSSAR 780
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  766 NYLIGEMIRKYV---EKILERDGKLTPFVYIESERKI---NGL----ISLSDHSEIRLKGFIDRVDEVLDA---IRIIDY 832
Cdd:COG3857    781 YRYLLERLKRLLkraRRWLEEEARRSGFEPVALELSFgpeGGLppleLELPNGRKIRLRGRIDRIDRLESDgryLRIIDY 860
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  833 KSGSgtTTFsSIESLFNKEEkdrakavMQVFMYcwMYAHLTENKGKTIQP-GIYYVR-------------------SLFA 892
Cdd:COG3857    861 KSGS--KKF-DLDDVYYGLA-------LQLPLY--LDAALENLEGKEAEPaGALYFHlknpklkakkplkklkmkgLLLD 928
                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2796580527  893 DPFDPSVYHRIERG--KSEKV---EDFSGYAQAFEEGLRGCLDEIFNPEI---PFtQTPTGKACSYCPFKGICG 958
Cdd:COG3857    929 DPEVLEIIPLKKDGsfKNSKVlseEEFEELLDHVRELLKEAGEEILAGDFainPY-RTKDRTACQYCPYKSICR 1001
 
Name Accession Description Interval E-value
AddB COG3857
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];
117-958 2.65e-71

ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];


Pssm-ID: 443066 [Multi-domain]  Cd Length: 1019  Bit Score: 255.83  E-value: 2.65e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  117 RMLFSNVtdLREIENDFDFLSDEQ-----IAAIRSFWSSFYPRGDTPNQ-QQFLAVW----QVLYDLYEEFRATLAAEGK 186
Cdd:COG3857     87 RMLLRKI--LEEHKDELKVFARAAdkpgfIEQLAELITELKRYGITPEDlEEAAELLkeklRDLALIYEAYEEKLAGRYI 164
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  187 GYEgMIFREVVESMErgESPDLPYEQIVFVGLNALSVSEEHFLAQLQKR----------EIADFYWDYVSDKV------- 249
Cdd:COG3857    165 DSE-DLLRLLAEKLE--KSEFLEGAEIYIDGFTDFTPQELELLEALLKKakevtitltlDPDELDLFSATGETyerllel 241
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  250 -TDPDNKASYFVSRNLKSFPSSMKLPPEEKVKTEIEVIGIPSGIGQAKHVYTLLSDWCKEAEMSSEEalrTAVILPDEHL 328
Cdd:COG3857    242 aKENGVEVEFKKSPELAHLERNLFAYPPEEEPEGIEIIEAANRRAEVEAVAREIRRLVREEGYRYRD---IAVVVRDLEA 318
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  329 LIPVLNAIPEQIR-RINVTMGYPLAGTPvasLIEYILALqknVRYIDRNplFYFRDVLPVLNHRYILSTSPEIISSLVKE 407
Cdd:COG3857    319 YAPLIERVFAEYGiPYFIDEKRPLSHHP---LVELILSL---LELVRSN--FRYEDVFRLLKTGLLRPLSREEIDRLENY 390
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  408 ITENN-------------KIYISHTELEKTPLLEILFTPVTG--------------VEAFSDYLIKVLEELNKVMSALSD 460
Cdd:COG3857    391 VLAYGirgrrwleryleeEEELTDEEEEDLERLNELRDRLLEpllplrerlkkaktVREWAEALYEFLEELGVPEKLEEW 470
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  461 EEEEDAPQRTNDLEQEFIFHYFTTV-NRMKEVMKDAriEMKIDTFFRLLKRVTDTITIPFHGEPLSGLQIMGVLETRALD 539
Cdd:COG3857    471 REAEEAGDLEEAREHEQAWNALIELlDELVEVLGDE--KLSLEEFLRILESGLEELTFGLIPPSLDQVQVGGLDRARGLD 548
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  540 FDRLIILSMNEGIFPQRKAANSFIPYNLRR-----GFGL-PTYEHQDSVWAYHFYRLIERAS-HVSLLYDTRSNGLQTGE 612
Cdd:COG3857    549 FKAVFVLGLNEGVFPARPREDGLLSDEERErlnelGLELpPTSRERLLEERFLFYRALTRASeRLYLSYPLADEEGKALL 628
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  613 VSRFVHQLHYHYEVPMRDKLVVYNVSSSKTP-------PLAVPKREDVMRRLDAYRkgGSKAISASAINTYLDCPLKFYF 685
Cdd:COG3857    629 PSPLIDRLRELFPELEERSLLEEELEYIGTPesalselAAALRQLELAPLWWDVYK--WLLKLSVSRLETYAACPFQFFL 706
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  686 SVVEGIReeEEVSETIESDVFGSILHKVMEELYKPFQGKMVTVDLLKAIRKDtALLTGAIARAFASEFFKtevVRSLTGQ 765
Cdd:COG3857    707 RYGLKLK--EREEYELDAPDRGTLFHAVLERFYKELKEEGLDWADLSDEELE-ELLEEAVEELAPELQNG---ILLSSAR 780
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  766 NYLIGEMIRKYV---EKILERDGKLTPFVYIESERKI---NGL----ISLSDHSEIRLKGFIDRVDEVLDA---IRIIDY 832
Cdd:COG3857    781 YRYLLERLKRLLkraRRWLEEEARRSGFEPVALELSFgpeGGLppleLELPNGRKIRLRGRIDRIDRLESDgryLRIIDY 860
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  833 KSGSgtTTFsSIESLFNKEEkdrakavMQVFMYcwMYAHLTENKGKTIQP-GIYYVR-------------------SLFA 892
Cdd:COG3857    861 KSGS--KKF-DLDDVYYGLA-------LQLPLY--LDAALENLEGKEAEPaGALYFHlknpklkakkplkklkmkgLLLD 928
                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2796580527  893 DPFDPSVYHRIERG--KSEKV---EDFSGYAQAFEEGLRGCLDEIFNPEI---PFtQTPTGKACSYCPFKGICG 958
Cdd:COG3857    929 DPEVLEIIPLKKDGsfKNSKVlseEEFEELLDHVRELLKEAGEEILAGDFainPY-RTKDRTACQYCPYKSICR 1001
PDDEXK_1 pfam12705
PD-(D/E)XK nuclease superfamily; Members of this family belong to the PD-(D/E)XK nuclease ...
667-957 8.48e-40

PD-(D/E)XK nuclease superfamily; Members of this family belong to the PD-(D/E)XK nuclease superfamily


Pssm-ID: 432731 [Multi-domain]  Cd Length: 250  Bit Score: 147.68  E-value: 8.48e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 667 AISASAINTYLDCPLKFYFSVVEGIReeeeVSETIESDVFGSILHKVMEELYKPfqgkmvtVDLLKAirKDTALLTGAIA 746
Cdd:pfam12705   1 RLSPSRLETYLTCPLRFFLRYLLGLR----EDEELDAPDLGTLVHAALERFYRW-------GRLPEE--DLEELLQALLE 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 747 RAFASEFFKTEVvrsLTGQNYLIG---EMIRKYVEKILERDGKLTPFVYIESERKINGlislsdhSEIRLKGFIDRVD-E 822
Cdd:pfam12705  68 ELWPELGLQSEI---LPRLPWLAGrlrRRLERMLRRLAEWLRARRGFRPVAVELGFGG-------TTVRLVGRIDRVDlD 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 823 VLDAIRIIDYKSGSGTTtfssieslfnKEEKDRAKAVMQVFMYCWMYAHLTENKGKTIqpGIYYVRSLFADPFDPSVYHR 902
Cdd:pfam12705 138 GEGYLRIIDYKTGSAPP----------QSEDLDLYEGLQLLLYLLALAAGEKALGGPA--GALYLRLDDPLKKDEEVVEP 205
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2796580527 903 IErgksEKVEDFsgyaQAFEEGLRGCLDEIFNPEIPFTQtptGKACSYCPFKGIC 957
Cdd:pfam12705 206 MV----LTEDEF----DALLQELRELAEEILAGEFPARP---GKKCRYCPYRSIC 249
TIGR03623 TIGR03623
probable DNA repair protein; Members of this protein family are bacterial proteins of about ...
482-839 2.72e-17

probable DNA repair protein; Members of this protein family are bacterial proteins of about 900 amino acids in length. Members show extended homology to proteins in TIGR02786, the AddB protein of double-strand break repair via homologous recombination. Members of this family, therefore, may be DNA repair proteins.


Pssm-ID: 274682 [Multi-domain]  Cd Length: 874  Bit Score: 87.02  E-value: 2.72e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 482 FTTVNRMKEVMKD-ARIE-----MKIDTFFRLLKR-VTDTITIPFHGEplSGLQIMGVLETRALDFDRLIILSMNEGIFP 554
Cdd:TIGR03623 409 YQAVKAWEELLAEfAALDlvspaLTFSEALRLLRQlAAETLFQPETPE--APIQVLGLLEAAGLQFDALWVMGLTDEQWP 486
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 555 QRKAANSFIPYNLRRGFGLPtyeHQDSV----WAYHFY-RLIERASHVSLLYdTRSNGLQTGEVSRFVHQLHYHYEV--- 626
Cdd:TIGR03623 487 APPRPNPFLPLALQRAVGMP---HASAEreldYARQVTqRLLKSAPEVVFSY-PRRDGDRELRPSPLIAHLPLKAEEdae 562
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 627 ---PMRDKLVVYNVSS------SKTPPLAVPKRedvMRrldayrkGGSKAISASAIntyldCPLKFYFSVVEGIREEEEV 697
Cdd:TIGR03623 563 ladYQDLAAAVAAGSRlevlddAQAPPLAAGER---IS-------GGTGLLKAQAA-----CPFRAFAQHRLGARALEEP 627
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 698 SETIESDVFGSILHKVMEELYKPFQGKmvtvDLLKAIRKDT--ALLTGAIARAFASEFFKTEvvRSLTGQnYLIGEMIR- 774
Cdd:TIGR03623 628 VDGLDALERGTLVHRVLELFWERLKNQ----EALNALDEAEleQLIAEAIEEALAEERARHS--QTFPER-FLELEQERl 700
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2796580527 775 -KYVEKILERDGKLTPFVYIESER----KINGLislsdhseiRLKGFIDRVDEVLDAIR-IIDYKSGSGTT 839
Cdd:TIGR03623 701 lQLLLEWLELERKRPPFEVVATEQnhsiEIGGL---------ELKLRIDRIDRLADGSRlIIDYKTGAPSV 762
 
Name Accession Description Interval E-value
AddB COG3857
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];
117-958 2.65e-71

ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];


Pssm-ID: 443066 [Multi-domain]  Cd Length: 1019  Bit Score: 255.83  E-value: 2.65e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  117 RMLFSNVtdLREIENDFDFLSDEQ-----IAAIRSFWSSFYPRGDTPNQ-QQFLAVW----QVLYDLYEEFRATLAAEGK 186
Cdd:COG3857     87 RMLLRKI--LEEHKDELKVFARAAdkpgfIEQLAELITELKRYGITPEDlEEAAELLkeklRDLALIYEAYEEKLAGRYI 164
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  187 GYEgMIFREVVESMErgESPDLPYEQIVFVGLNALSVSEEHFLAQLQKR----------EIADFYWDYVSDKV------- 249
Cdd:COG3857    165 DSE-DLLRLLAEKLE--KSEFLEGAEIYIDGFTDFTPQELELLEALLKKakevtitltlDPDELDLFSATGETyerllel 241
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  250 -TDPDNKASYFVSRNLKSFPSSMKLPPEEKVKTEIEVIGIPSGIGQAKHVYTLLSDWCKEAEMSSEEalrTAVILPDEHL 328
Cdd:COG3857    242 aKENGVEVEFKKSPELAHLERNLFAYPPEEEPEGIEIIEAANRRAEVEAVAREIRRLVREEGYRYRD---IAVVVRDLEA 318
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  329 LIPVLNAIPEQIR-RINVTMGYPLAGTPvasLIEYILALqknVRYIDRNplFYFRDVLPVLNHRYILSTSPEIISSLVKE 407
Cdd:COG3857    319 YAPLIERVFAEYGiPYFIDEKRPLSHHP---LVELILSL---LELVRSN--FRYEDVFRLLKTGLLRPLSREEIDRLENY 390
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  408 ITENN-------------KIYISHTELEKTPLLEILFTPVTG--------------VEAFSDYLIKVLEELNKVMSALSD 460
Cdd:COG3857    391 VLAYGirgrrwleryleeEEELTDEEEEDLERLNELRDRLLEpllplrerlkkaktVREWAEALYEFLEELGVPEKLEEW 470
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  461 EEEEDAPQRTNDLEQEFIFHYFTTV-NRMKEVMKDAriEMKIDTFFRLLKRVTDTITIPFHGEPLSGLQIMGVLETRALD 539
Cdd:COG3857    471 REAEEAGDLEEAREHEQAWNALIELlDELVEVLGDE--KLSLEEFLRILESGLEELTFGLIPPSLDQVQVGGLDRARGLD 548
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  540 FDRLIILSMNEGIFPQRKAANSFIPYNLRR-----GFGL-PTYEHQDSVWAYHFYRLIERAS-HVSLLYDTRSNGLQTGE 612
Cdd:COG3857    549 FKAVFVLGLNEGVFPARPREDGLLSDEERErlnelGLELpPTSRERLLEERFLFYRALTRASeRLYLSYPLADEEGKALL 628
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  613 VSRFVHQLHYHYEVPMRDKLVVYNVSSSKTP-------PLAVPKREDVMRRLDAYRkgGSKAISASAINTYLDCPLKFYF 685
Cdd:COG3857    629 PSPLIDRLRELFPELEERSLLEEELEYIGTPesalselAAALRQLELAPLWWDVYK--WLLKLSVSRLETYAACPFQFFL 706
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  686 SVVEGIReeEEVSETIESDVFGSILHKVMEELYKPFQGKMVTVDLLKAIRKDtALLTGAIARAFASEFFKtevVRSLTGQ 765
Cdd:COG3857    707 RYGLKLK--EREEYELDAPDRGTLFHAVLERFYKELKEEGLDWADLSDEELE-ELLEEAVEELAPELQNG---ILLSSAR 780
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  766 NYLIGEMIRKYV---EKILERDGKLTPFVYIESERKI---NGL----ISLSDHSEIRLKGFIDRVDEVLDA---IRIIDY 832
Cdd:COG3857    781 YRYLLERLKRLLkraRRWLEEEARRSGFEPVALELSFgpeGGLppleLELPNGRKIRLRGRIDRIDRLESDgryLRIIDY 860
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  833 KSGSgtTTFsSIESLFNKEEkdrakavMQVFMYcwMYAHLTENKGKTIQP-GIYYVR-------------------SLFA 892
Cdd:COG3857    861 KSGS--KKF-DLDDVYYGLA-------LQLPLY--LDAALENLEGKEAEPaGALYFHlknpklkakkplkklkmkgLLLD 928
                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2796580527  893 DPFDPSVYHRIERG--KSEKV---EDFSGYAQAFEEGLRGCLDEIFNPEI---PFtQTPTGKACSYCPFKGICG 958
Cdd:COG3857    929 DPEVLEIIPLKKDGsfKNSKVlseEEFEELLDHVRELLKEAGEEILAGDFainPY-RTKDRTACQYCPYKSICR 1001
COG3893 COG3893
Inactivated superfamily I helicase [Replication, recombination and repair];
1-840 1.22e-61

Inactivated superfamily I helicase [Replication, recombination and repair];


Pssm-ID: 443100 [Multi-domain]  Cd Length: 965  Bit Score: 226.98  E-value: 1.22e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527   1 MKPFLYQVASLFYEKWGA---EVSRLAFVFPNRRTGLFFQKYLSEVADTPLFSPTILTINDLFIQLSGKQ---SADRISM 74
Cdd:COG3893     9 GAPFLDALAAGLLARLAGdplALARVTILLPTRRAARALREAFLRLLGRALLLPRIRPLGDLDEDELLLDlppAISPLER 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527  75 LFTLYDIYIR--QSGSTETFDEFLYWGEMLLNDFDDIDKYMANARMLFSNVTDlreiendfDFLSDEQIAairsfwssfy 152
Cdd:COG3893    89 RLLLARLVRRwaDALVPASPADALDLADSLARLMDELETEGVDLEALADLVPD--------DLAGHWQRT---------- 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 153 prgdtpnqQQFLAVwqvlydLYEEFRATLAAEGKGYEGMIFREVVEsMERGESPDLPYEQIVFVGLNALSVSEEHFLAQL 232
Cdd:COG3893   151 --------LDFLKI------VTEAWPAILAERGLIDPAARRRALLE-ALAARWRAAPAGPVIAAGSTGSTPATARLLAAV 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 233 QKREIADFYWDYVsDKVTDPDNKASYFVSR---NLKSFPSSMKLPPEEkvkteIEVIGIPSG-------IGQAKHVYTLL 302
Cdd:COG3893   216 ARLPQGAVVLPGL-DLDLDEAAWAALAEDHpqyGLKRLLDRLGVTRED-----VRPWGATPAlpararlLSEALRPAETT 289
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 303 SDWCK------------EAEMSSEEAL---------------RTAVILPDEHLLIPVLNAIPEQIRRINVTMGYPLAGTP 355
Cdd:COG3893   290 DAWRDlgaaalagltliEAADPEEEALaialalrealeepgrTAALVTPDRALARRVAAELERWGIEVDDSAGWPLSTTP 369
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 356 VASLIEYILALQknvryidRNPlFYFRDVLPVLNHRYILSTSP-----------EI-----------ISSLVKEITENNK 413
Cdd:COG3893   370 AGALLRLLLELA-------AEP-LAPVALLALLKHPLVRLGLGrgdhrravralELalrrggrpapgLAGLRAALARARP 441
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 414 IYISHTE-----LEK--TPLLEILFTPVTGVEAFSDYLIKVLEELnkvmsALSDEEEEDAPQRTNDLEQefifhYFTTVN 486
Cdd:COG3893   442 DDAEAAAalldrLEAalAPLLALFAAGKRPLADWLAALRALLEAL-----GADEEGGEDALWAGEAGEA-----LLELLA 511
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 487 RMKEVmKDARIEMKIDTFFRLLKRVTDTITIPFHGEPLSGLQIMGVLETRALDFDRLIILSMNEGIFPQRKAANSFIPYN 566
Cdd:COG3893   512 ELAAA-AGAGGPLSAAEYPALLRALLEGTTVRPPGGPHPRVQILGLLEARLQRFDAVILGGLNEGVWPPAPRPDPWLSRP 590
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 567 LRRGFGLPTYEHQDSVWAYHFYRLIeRASHVSLLYDTRSNGlQTGEVSRFVHQL----HYHYEVPMRDKLVVYNVS---S 639
Cdd:COG3893   591 MRRALGLPTPERRIGLAAHDFAQAL-GAPEVVLSRARRSDG-APTVPSRWLQRLeallGGAALAAMGARWLAWARAldrP 668
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 640 SKTPPLAVPK-REDVMRRLdayrkggsKAISASAINTYLDCPLKFYFSVVEGIREEEEVSETIESDVFGSILHKVMEELY 718
Cdd:COG3893   669 APVAPAARPApKPPVARRP--------RLSSVTIETLLRDPPYAYYARRLLLLLLLPPLADPPAAARGGLLHHALLEFFE 740
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 719 KPFQGkmvtvdllkAIRKDTALLTGAIARAFASEFFKTEVVRSLTGQNYLIGEMIRKYVEKilERDGKLTPFVYIESERk 798
Cdd:COG3893   741 REPPA---------LPADAAAALLLALAEALLALAAAPAAAAAWWARRLRRAAAFAAAEEE--RRRALAREEAEEEGGR- 808
                         890       900       910       920
                  ....*....|....*....|....*....|....*....|..
gi 2796580527 799 ingLISLSDHSEIRLKGFIDRVDEVLDAIRIIDYKSGSGTTT 840
Cdd:COG3893   809 ---LALLEGGLLLLLRRRDRDDDDGDGDGGDDDKTTTTGPPA 847
PDDEXK_1 pfam12705
PD-(D/E)XK nuclease superfamily; Members of this family belong to the PD-(D/E)XK nuclease ...
667-957 8.48e-40

PD-(D/E)XK nuclease superfamily; Members of this family belong to the PD-(D/E)XK nuclease superfamily


Pssm-ID: 432731 [Multi-domain]  Cd Length: 250  Bit Score: 147.68  E-value: 8.48e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 667 AISASAINTYLDCPLKFYFSVVEGIReeeeVSETIESDVFGSILHKVMEELYKPfqgkmvtVDLLKAirKDTALLTGAIA 746
Cdd:pfam12705   1 RLSPSRLETYLTCPLRFFLRYLLGLR----EDEELDAPDLGTLVHAALERFYRW-------GRLPEE--DLEELLQALLE 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 747 RAFASEFFKTEVvrsLTGQNYLIG---EMIRKYVEKILERDGKLTPFVYIESERKINGlislsdhSEIRLKGFIDRVD-E 822
Cdd:pfam12705  68 ELWPELGLQSEI---LPRLPWLAGrlrRRLERMLRRLAEWLRARRGFRPVAVELGFGG-------TTVRLVGRIDRVDlD 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 823 VLDAIRIIDYKSGSGTTtfssieslfnKEEKDRAKAVMQVFMYCWMYAHLTENKGKTIqpGIYYVRSLFADPFDPSVYHR 902
Cdd:pfam12705 138 GEGYLRIIDYKTGSAPP----------QSEDLDLYEGLQLLLYLLALAAGEKALGGPA--GALYLRLDDPLKKDEEVVEP 205
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2796580527 903 IErgksEKVEDFsgyaQAFEEGLRGCLDEIFNPEIPFTQtptGKACSYCPFKGIC 957
Cdd:pfam12705 206 MV----LTEDEF----DALLQELRELAEEILAGEFPARP---GKKCRYCPYRSIC 249
Slr0479 COG2887
RecB family exonuclease [Replication, recombination and repair];
666-957 2.08e-39

RecB family exonuclease [Replication, recombination and repair];


Pssm-ID: 442133 [Multi-domain]  Cd Length: 248  Bit Score: 146.72  E-value: 2.08e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 666 KAISASAINTYLDCPLKFYFSVVEGIREEEEVSETIEsdVFGSILHKVMEELYKPFQGKMvtvdllkairkDTALLTGAI 745
Cdd:COG2887     1 RRLSPSRIETLLRCPLRYYARYILGLRDPLEPPPDAA--DRGTLVHAVLERFYKLPADEL-----------PAEELLALL 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 746 ARAFASEFFKTEVVRSLtgqnYLigEMIRKYVEKILERDGKLTPFVYIESERKINGLISlsdhSEIRLKGFIDRVDEVLD 825
Cdd:COG2887    68 EEAWAELGFEDPWAAAL----WL--ERAERLLEAFLEWERAPAGLEPVAVEVEFELELP----GGVRLRGRIDRIDRLPD 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 826 -AIRIIDYKSGSgtttfssieslfNKEEKDRAKAVMQVFMYCWMYAHLTENKGKTiQPGIYYVRSLfadpfdpsvyhrie 904
Cdd:COG2887   138 gRLVVVDYKTGK------------APSTKDEAGEDPQLALYALALERGFEGLVPA-GARLVYLGDL-------------- 190
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2796580527 905 rGKSEKVEDFSGYAQAFEEGLRGCLDEIFNPEIPFTQTPTGKACSYCPFKGIC 957
Cdd:COG2887   191 -GKKKVLDPLEEELEEAEERLEELAAAIADPEGPFPARPNPPLCRYCDYRHLC 242
TIGR03623 TIGR03623
probable DNA repair protein; Members of this protein family are bacterial proteins of about ...
482-839 2.72e-17

probable DNA repair protein; Members of this protein family are bacterial proteins of about 900 amino acids in length. Members show extended homology to proteins in TIGR02786, the AddB protein of double-strand break repair via homologous recombination. Members of this family, therefore, may be DNA repair proteins.


Pssm-ID: 274682 [Multi-domain]  Cd Length: 874  Bit Score: 87.02  E-value: 2.72e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 482 FTTVNRMKEVMKD-ARIE-----MKIDTFFRLLKR-VTDTITIPFHGEplSGLQIMGVLETRALDFDRLIILSMNEGIFP 554
Cdd:TIGR03623 409 YQAVKAWEELLAEfAALDlvspaLTFSEALRLLRQlAAETLFQPETPE--APIQVLGLLEAAGLQFDALWVMGLTDEQWP 486
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 555 QRKAANSFIPYNLRRGFGLPtyeHQDSV----WAYHFY-RLIERASHVSLLYdTRSNGLQTGEVSRFVHQLHYHYEV--- 626
Cdd:TIGR03623 487 APPRPNPFLPLALQRAVGMP---HASAEreldYARQVTqRLLKSAPEVVFSY-PRRDGDRELRPSPLIAHLPLKAEEdae 562
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 627 ---PMRDKLVVYNVSS------SKTPPLAVPKRedvMRrldayrkGGSKAISASAIntyldCPLKFYFSVVEGIREEEEV 697
Cdd:TIGR03623 563 ladYQDLAAAVAAGSRlevlddAQAPPLAAGER---IS-------GGTGLLKAQAA-----CPFRAFAQHRLGARALEEP 627
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 698 SETIESDVFGSILHKVMEELYKPFQGKmvtvDLLKAIRKDT--ALLTGAIARAFASEFFKTEvvRSLTGQnYLIGEMIR- 774
Cdd:TIGR03623 628 VDGLDALERGTLVHRVLELFWERLKNQ----EALNALDEAEleQLIAEAIEEALAEERARHS--QTFPER-FLELEQERl 700
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2796580527 775 -KYVEKILERDGKLTPFVYIESER----KINGLislsdhseiRLKGFIDRVDEVLDAIR-IIDYKSGSGTT 839
Cdd:TIGR03623 701 lQLLLEWLELERKRPPFEVVATEQnhsiEIGGL---------ELKLRIDRIDRLADGSRlIIDYKTGAPSV 762
RecB COG1074
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, ...
706-888 7.70e-04

3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];


Pssm-ID: 440692 [Multi-domain]  Cd Length: 866  Bit Score: 43.41  E-value: 7.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 706 FGSILHKVMEELykPFQGkmvTVDLLKAIRKdtALLTGAIARAFASE-------FFKTEVVRSLTGQNYLIGEMirkyve 778
Cdd:COG1074   714 RGTLVHRLLEHL--DFSA---PAELRAALAR--LLARGGLDEEEAEAlaeallaFLATPLLAELFAAAEVLREV------ 780
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 779 kilerdgkltPFVYIESERKINGLIslsdhseirlKGFIDRVDEVLDAIRIIDYKSGSGTTTFssieslfnkEEKDRAKA 858
Cdd:COG1074   781 ----------PFLLPDLYRGLGGLL----------KGRIDLVFEDDGRVYIVDYKTNRLGPDD---------EEYLPERY 831
                         170       180       190
                  ....*....|....*....|....*....|
gi 2796580527 859 VMQVFMYCWMYAHLTenKGKTIQPGIYYVR 888
Cdd:COG1074   832 RLQLALYALALERLL--PGRPVRAGLYFTD 859
VWA pfam00092
von Willebrand factor type A domain;
761-859 9.35e-03

von Willebrand factor type A domain;


Pssm-ID: 459670 [Multi-domain]  Cd Length: 174  Bit Score: 38.02  E-value: 9.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796580527 761 SLTGQNYligEMIRKYVEKILERdgkltpfvYIESERKIN-GLISLSDHS--EIRLKGFIDRvDEVLDAIRIIDYKSGSG 837
Cdd:pfam00092  11 SIGGDNF---EKVKEFLKKLVES--------LDIGPDGTRvGLVQYSSDVrtEFPLNDYSSK-EELLSAVDNLRYLGGGT 78
                          90       100
                  ....*....|....*....|....*.
gi 2796580527 838 TTTFSSI----ESLFNKEEKDRAKAV 859
Cdd:pfam00092  79 TNTGKALkyalENLFSSAAGARPGAP 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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