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Conserved domains on  [gi|2796469736|ref|WP_373179697|]
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aldo/keto reductase family protein [Bacteroides uniformis]

Protein Classification

aldo/keto reductase family protein( domain architecture ID 14442260)

aldo/keto reductase family protein is an oxidoreductase that may catalyze the reduction of aldehydes and/or ketones to their corresponding primary and secondary alcohols

EC:  1.-.-.-
Gene Ontology:  GO:0016491
PubMed:  12604248|9307009|16970545|25304492

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
 1-144 7.47e-69

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


:

Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 210.03  E-value: 7.47e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   1 MWEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSHfrsvePR 80
Cdd:cd19071   112 TWRALEELVDEGLVRSIGVSNFNVEHLEELLAAARIKPAVNQIELHPYLQQKELVEFCKEHGIVVQAYSPLGR-----GR 186

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2796469736  81 LEIIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEI 144
Cdd:cd19071   187 RPLLDDPVLKEIAKKYGKTPAQVLLRWALQRGVVVIPKSSNPERIKENLDVFDFELSEEDMAAI 250
 
Name Accession Description Interval E-value
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
 1-144 7.47e-69

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 210.03  E-value: 7.47e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   1 MWEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSHfrsvePR 80
Cdd:cd19071   112 TWRALEELVDEGLVRSIGVSNFNVEHLEELLAAARIKPAVNQIELHPYLQQKELVEFCKEHGIVVQAYSPLGR-----GR 186

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2796469736  81 LEIIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEI 144
Cdd:cd19071   187 RPLLDDPVLKEIAKKYGKTPAQVLLRWALQRGVVVIPKSSNPERIKENLDVFDFELSEEDMAAI 250
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 2-157 2.65e-68

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 209.14  E-value: 2.65e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFShfrsvepRL 81
Cdd:COG0656   110 WRALEELYEEGLIRAIGVSNFDPEHLEELLAETGVKPAVNQVELHPYLQQRELLAFCREHGIVVEAYSPLG-------RG 182

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2796469736  82 EIIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLNKGRYLNYNP 157
Cdd:COG0656   183 KLLDDPVLAEIAEKHGKTPAQVVLRWHLQRGVVVIPKSVTPERIRENLDAFDFELSDEDMAAIDALDRGERLGPDP 258
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
2-157 6.76e-35

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 124.03  E-value: 6.76e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSHFRSveprl 81
Cdd:PRK11565  120 WKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGGK----- 194

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2796469736  82 EIIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLNKGRYLNYNP 157
Cdd:PRK11565  195 GVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVFDFRLDKDELGEIAKLDQGKRLGPDP 270
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 2-148 2.30e-28

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 107.40  E-value: 2.30e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIE--LTKYCQDRGIAVEAMSTFSH------ 73
Cdd:pfam00248 120 WDALEELKKEGKIRAIGVSNFDAEQIEKALTKGKIPIVAVQVEYNLLRRRQEeeLLEYCKKNGIPLIAYSPLGGglltgk 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  74 -------FRSVEPRLEIIEHPLIL-------AIAKKHGKSTVQIVLRWLVQ--RGIIVIPKTWNMVHLKENISILDFELS 137
Cdd:pfam00248 200 ytrdpdkGPGERRRLLKKGTPLNLealealeEIAKEHGVSPAQVALRWALSkpGVTIPIPGASNPEQLEDNLGALEFPLS 279

                         170
                  ....*....|.
gi 2796469736 138 VDEMAEITSLN 148
Cdd:pfam00248 280 DEEVARIDELL 290
 
Name Accession Description Interval E-value
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
 1-144 7.47e-69

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 210.03  E-value: 7.47e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   1 MWEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSHfrsvePR 80
Cdd:cd19071   112 TWRALEELVDEGLVRSIGVSNFNVEHLEELLAAARIKPAVNQIELHPYLQQKELVEFCKEHGIVVQAYSPLGR-----GR 186

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2796469736  81 LEIIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEI 144
Cdd:cd19071   187 RPLLDDPVLKEIAKKYGKTPAQVLLRWALQRGVVVIPKSSNPERIKENLDVFDFELSEEDMAAI 250
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 2-157 2.65e-68

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 209.14  E-value: 2.65e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFShfrsvepRL 81
Cdd:COG0656   110 WRALEELYEEGLIRAIGVSNFDPEHLEELLAETGVKPAVNQVELHPYLQQRELLAFCREHGIVVEAYSPLG-------RG 182

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2796469736  82 EIIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLNKGRYLNYNP 157
Cdd:COG0656   183 KLLDDPVLAEIAEKHGKTPAQVVLRWHLQRGVVVIPKSVTPERIRENLDAFDFELSDEDMAAIDALDRGERLGPDP 258
AKR_AKR5F1 cd19133
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ...
 2-148 1.07e-58

the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381359 [Multi-domain]  Cd Length: 255  Bit Score: 184.32  E-value: 1.07e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSHFRSveprl 81
Cdd:cd19133   114 WRAMEELYKEGKIRAIGVSNFYPDRLVDLILHNEVKPAVNQIETHPFNQQIEAVEFLKKYGVQIEAWGPFAEGRN----- 188

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2796469736  82 EIIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLN 148
Cdd:cd19133   189 NLFENPVLTEIAEKYGKSVAQVILRWLIQRGIVVIPKSVRPERIAENFDIFDFELSDEDMEAIAALD 255
AKR_DrGR-like cd19136
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ...
 2-147 5.86e-57

Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).


Pssm-ID: 381362 [Multi-domain]  Cd Length: 262  Bit Score: 180.14  E-value: 5.86e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFShfrsvEPRL 81
Cdd:cd19136   122 WRALEDLYKEGKLRAIGVSNYTVRHLEELLKYCEVPPAVNQVEFHPHLVQKELLKFCKDHGIHLQAYSSLG-----SGDL 196

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2796469736  82 EIIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSL 147
Cdd:cd19136   197 RLLEDPTVLAIAKKYGRTPAQVLLRWALQQGIGVIPKSTNPERIAENIKVFDFELSEEDMAELNAL 262
AKR_AKR5G1-3 cd19157
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ...
 2-157 2.15e-53

AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381383 [Multi-domain]  Cd Length: 265  Bit Score: 171.42  E-value: 2.15e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMStfshfrsvePRL 81
Cdd:cd19157   116 WKALEKLYKDGRVRAIGVSNFQVHHLEDLLADAEIVPMVNQVEFHPRLTQKELRDYCKKQGIQLEAWS---------PLM 186

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2796469736  82 --EIIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLNKGRYLNYNP 157
Cdd:cd19157   187 qgQLLDNPVLKEIAEKYNKSVAQVILRWDLQNGVVTIPKSIKEHRIIENADVFDFELSQEDMDKIDALNENLRVGPDP 264
AKR_AKR5A_5G cd19126
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ...
 2-148 5.10e-52

AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381352 [Multi-domain]  Cd Length: 254  Bit Score: 167.61  E-value: 5.10e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFShfrsvepRL 81
Cdd:cd19126   115 WKALEKLYASGKVKAIGVSNFQEHHLEELLAHADVVPAVNQVEFHPYLTQKELRGYCKSKGIVVEAWSPLG-------QG 187

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2796469736  82 EIIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLN 148
Cdd:cd19126   188 GLLSNPVLAAIGEKYGKSAAQVVLRWDIQHGVVTIPKSVHASRIKENADIFDFELSEDDMTAIDALN 254
AKR_AKR2E1-5 cd19116
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ...
 2-151 7.86e-51

AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.


Pssm-ID: 381342 [Multi-domain]  Cd Length: 292  Bit Score: 165.53  E-value: 7.86e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAmstFSHFRSVEPRL 81
Cdd:cd19116   138 WRGMEDLVKLGLTRSIGVSNFNSEQINRLLSNCNIKPAVNQIEVHPTLTQEKLVAYCQSNGIVVMA---YSPFGRLVPRG 214

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2796469736  82 E-----IIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLNKGR 151
Cdd:cd19116   215 QtnpppRLDDPTLVAIAKKYGKTTAQIVLRYLIDRGVVPIPKSSNKKRIKENIDIFDFQLTPEEVAALNSFNTNQ 289
AKR_AKR5B1 cd19127
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ...
 2-148 7.43e-50

AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.


Pssm-ID: 381353 [Multi-domain]  Cd Length: 268  Bit Score: 162.19  E-value: 7.43e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSHFRSVEP-- 79
Cdd:cd19127   117 YKALEKLLAEGRVRAIGVSNFTPEHLERLIDATTVVPAVNQVELHPYFSQKDLRAFHRRLGIVTQAWSPIGGVMRYGAsg 196

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2796469736  80 ---RLEIIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLN 148
Cdd:cd19127   197 ptgPGDVLQDPTITGLAEKYGKTPAQIVLRWHLQNGVSAIPKSVHPERIAENIDIFDFALSAEDMAAIDALD 268
AKR_CeZK1290-like cd19135
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ...
 2-147 1.14e-47

Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381361 [Multi-domain]  Cd Length: 265  Bit Score: 156.72  E-value: 1.14e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFShfrsvepRL 81
Cdd:cd19135   126 WRALEELYDEGLCRAIGVSNFLIEHLEQLLEDCSVVPHVNQVEFHPFQNPVELIEYCRDNNIVFEGYCPLA-------KG 198

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2796469736  82 EIIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSL 147
Cdd:cd19135   199 KALEEPTVTELAKKYQKTPAQILIRWSIQNGVVTIPKSTKEERIKENCQVFDFSLSEEDMATLDSL 264
AKR_AKR5A1_2 cd19156
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ...
 2-157 4.80e-47

AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.


Pssm-ID: 381382 [Multi-domain]  Cd Length: 266  Bit Score: 154.98  E-value: 4.80e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSHFrsveprl 81
Cdd:cd19156   115 WKAFEKLYKEKKVRAIGVSNFHEHHLEELLKSCKVAPMVNQIELHPLLTQEPLRKFCKEKNIAVEAWSPLGQG------- 187

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2796469736  82 EIIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLNKGRYLNYNP 157
Cdd:cd19156   188 KLLSNPVLKAIGKKYGKSAAQVIIRWDIQHGIITIPKSVHEERIQENFDVFDFELTAEEIRQIDGLNTDHRYGPDP 263
AKR_AKR5D1_E1 cd19132
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ...
 2-148 1.07e-46

AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381358 [Multi-domain]  Cd Length: 255  Bit Score: 153.97  E-value: 1.07e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFShfrsvePRL 81
Cdd:cd19132   114 WQALIEAREEGLVRSIGVSNFLPEHLDRLIDETGVTPAVNQIELHPYFPQAEQRAYHREHGIVTQSWSPLG------RGS 187

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2796469736  82 EIIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLN 148
Cdd:cd19132   188 GLLDEPVIKAIAEKHGKTPAQVVLRWHVQLGVVPIPKSANPERQRENLAIFDFELSDEDMAAIAALD 254
AKR_AKR5C2 cd19131
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ...
 2-148 6.65e-46

Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.


Pssm-ID: 381357 [Multi-domain]  Cd Length: 256  Bit Score: 151.76  E-value: 6.65e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSHFRsveprl 81
Cdd:cd19131   117 WKALIELKKEGRVKSIGVSNFTIEHLQRLIDETGVVPVVNQIELHPRFQQRELRAFHAKHGIQTESWSPLGQGG------ 190

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2796469736  82 eIIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLN 148
Cdd:cd19131   191 -LLSDPVIGEIAEKHGKTPAQVVIRWHLQNGLVVIPKSVTPSRIAENFDVFDFELDADDMQAIAGLD 256
AKR_AKR3F2_3 cd19073
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ...
 5-144 1.28e-44

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381299 [Multi-domain]  Cd Length: 243  Bit Score: 148.19  E-value: 1.28e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   5 LEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFShfrsvepRLEII 84
Cdd:cd19073   110 LKELKEAGKVKSIGVSNFTIELLEEALDISPLPIAVNQVEFHPFLYQAELLEYCRENDIVITAYSPLA-------RGEVL 182

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  85 EHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEI 144
Cdd:cd19073   183 RDPVIQEIAEKYDKTPAQVALRWLVQKGIVVIPKASSEDHLKENLAIFDWELTSEDVAKI 242
AKR_AKR3G1 cd19123
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ...
 2-153 2.56e-43

AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.


Pssm-ID: 381349 [Multi-domain]  Cd Length: 297  Bit Score: 146.40  E-value: 2.56e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTF------SHFR 75
Cdd:cd19123   140 WRAMEELVDKGLCRHIGVSNFSVKKLEDLLATARIKPAVNQVELHPYLQQPELLAFCRDNGIHLTAYSPLgsgdrpAAMK 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  76 SV-EPRLeiIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLNKG-RYL 153
Cdd:cd19123   220 AEgEPVL--LEDPVINKIAEKHGASPAQVLIAWAIQRGTVVIPKSVNPERIQQNLEAAEVELDASDMATIAALDRHhRYV 297
AKR_AKR1A1-4 cd19106
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ...
 2-152 9.26e-43

AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.


Pssm-ID: 381332 [Multi-domain]  Cd Length: 305  Bit Score: 145.22  E-value: 9.26e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSH-----FRS 76
Cdd:cd19106   137 WKAMEKLVDKGLVKAIGLSNFNSRQIDDILSVARIKPAVLQVECHPYLAQNELIAHCKARGLVVTAYSPLGSpdrpwAKP 216

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2796469736  77 VEPRLeiIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLNKG-RY 152
Cdd:cd19106   217 DEPVL--LEEPKVKALAKKYNKSPAQILLRWQVQRGVVVIPKSVTPSRIKQNIQVFDFTLSPEEMKQLDALNRNwRY 291
AKR_AKR3C2-3 cd19120
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ...
 1-152 1.94e-42

Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.


Pssm-ID: 381346 [Multi-domain]  Cd Length: 269  Bit Score: 143.14  E-value: 1.94e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   1 MWEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNA--QIELTKYCQDRGIAVEAMSTFSHFRSVE 78
Cdd:cd19120   118 AWAELEALKDAGLVRSIGVSNFRIEDLEELLDTAKIKPAVNQIEFHPYLYpqQPALLEYCREHGIVVSAYSPLSPLTRDA 197

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2796469736  79 PRLeiIEHPLiLAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLNKGRY 152
Cdd:cd19120   198 GGP--LDPVL-EKIAEKYGVTPAQVLLRWALQKGIVVVTTSSKEERMKEYLEAFDFELTEEEVEEIDKAGKQKH 268
AKR_AKR4C1-15 cd19125
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ...
 2-154 5.60e-42

AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.


Pssm-ID: 381351 [Multi-domain]  Cd Length: 287  Bit Score: 142.48  E-value: 5.60e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSHFRSVEPRL 81
Cdd:cd19125   135 WKAMEKLVDSGKVRAIGVSNFSVKKLEDLLAVARVPPAVNQVECHPGWQQDKLHEFCKSKGIHLSAYSPLGSPGTTWVKK 214

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2796469736  82 EIIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLNKGRYLN 154
Cdd:cd19125   215 NVLKDPIVTKVAEKLGKTPAQVALRWGLQRGTSVLPKSTNEERIKENIDVFDWSIPEEDFAKFSSIEQQRRVL 287
AKR_AKR5C1 cd19130
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ...
 2-148 1.32e-40

Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.


Pssm-ID: 381356 [Multi-domain]  Cd Length: 256  Bit Score: 138.12  E-value: 1.32e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSHFRsveprl 81
Cdd:cd19130   117 WEAMIELRAAGRTRSIGVSNFLPPHLERIVAATGVVPAVNQIELHPAYQQRTIRDWAQAHDVKIEAWSPLGQGK------ 190

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2796469736  82 eIIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLN 148
Cdd:cd19130   191 -LLGDPPVGAIAAAHGKTPAQIVLRWHLQKGHVVFPKSVRRERMEDNLDVFDFDLTDTEIAAIDALD 256
AKR_AKR1G1_CeAKR cd19154
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ...
 2-150 1.93e-40

Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381380 [Multi-domain]  Cd Length: 303  Bit Score: 139.08  E-value: 1.93e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTF---------- 71
Cdd:cd19154   141 WRGMEKVYDEGLTKAIGVSNFNNDQIQRILDNARVKPHNNQVECHLYFPQKELVEFCKKHNISVTSYATLgspgranftk 220

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2796469736  72 SHFRSVEPRLeiIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLNKG 150
Cdd:cd19154   221 STGVSPAPNL--LQDPIVKAIAEKHGKTPAQVLLRYLLQRGIAVIPKSATPSRIKENFNIFDFSLSEEDMATLEEIEKS 297
AKR_AKR3A1-2 cd19117
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ...
 2-149 1.42e-39

AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.


Pssm-ID: 381343 [Multi-domain]  Cd Length: 284  Bit Score: 136.47  E-value: 1.42e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEAL--SEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSHFRSvep 79
Cdd:cd19117   139 WELMQKLPATGKVKAIGVSNFSIKNLEKLlaSPSAKIVPAVNQIELHPLLPQPKLVDFCKSKGIHATAYSPLGSTNA--- 215

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  80 rlEIIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISIldFELSVDEMAEITSLNK 149
Cdd:cd19117   216 --PLLKEPVIIKIAKKHGKTPAQVIISWGLQRGYSVLPKSVTPSRIESNFKL--FTLSDEEFKEIDELHK 281
AKR_AKR2D1 cd19115
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ...
 2-157 1.64e-38

AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.


Pssm-ID: 381341 [Multi-domain]  Cd Length: 311  Bit Score: 134.47  E-value: 1.64e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSHFRSVEPRL 81
Cdd:cd19115   147 WTAMEKLVDKGLARSIGVSNFSAQLLMDLLRYARIRPATLQIEHHPYLTQPRLVKYAQKEGIAVTAYSSFGPQSFLELDL 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  82 E-------IIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLNKGRYLN 154
Cdd:cd19115   227 PgakdtppLFEHDVIKSIAEKHGKTPAQVLLRWATQRGIAVIPKSNNPKRLAQNLDVTGFDLEAEEIKAISALDIGLRFN 306


                  ...
gi 2796469736 155 yNP 157
Cdd:cd19115   307 -NP 308
AKR_AKR3F3 cd19140
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ...
 5-147 5.61e-38

Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381366 [Multi-domain]  Cd Length: 253  Bit Score: 131.23  E-value: 5.61e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   5 LEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFShfrsvepRLEII 84
Cdd:cd19140   117 LNEAQEAGLARHIGVSNFTVALLREAVELSEAPLFTNQVEYHPYLDQRKLLDAAREHGIALTAYSPLA-------RGEVL 189

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2796469736  85 EHPLILAIAKKHGKSTVQIVLRWLVQR-GIIVIPKTWNMVHLKENISILDFELSVDEMAEITSL 147
Cdd:cd19140   190 KDPVLQEIGRKHGKTPAQVALRWLLQQeGVAAIPKATNPERLEENLDIFDFTLSDEEMARIAAL 253
AKR_AKR2A1-2 cd19112
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ...
 2-156 3.22e-37

AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.


Pssm-ID: 381338 [Multi-domain]  Cd Length: 308  Bit Score: 131.07  E-value: 3.22e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSN---FLQPHIEALSEISdvvPAVNQIEISPLNAQIELTKYCQDRGIAVEA-------MSTF 71
Cdd:cd19112   142 WHAMEKLVSAGLVRSIGISNydiFLTRDCLAYSKIK---PAVNQIETHPYFQRDSLVKFCQKHGISVTAhtplggaAANA 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  72 SHFRSVEPrleiIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLNkgR 151
Cdd:cd19112   219 EWFGSVSP----LDDPVLKDLAKKYGKSAAQIVLRWGIQRNTAVIPKSSKPERLKENIDVFDFQLSKEDMKLIKSLD--R 292


                  ....*
gi 2796469736 152 YLNYN 156
Cdd:cd19112   293 KYRTN 297
AKR_AKR3B1-3 cd19118
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ...
 2-147 1.67e-36

AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.


Pssm-ID: 381344 [Multi-domain]  Cd Length: 283  Bit Score: 128.30  E-value: 1.67e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSHFRSVEPRL 81
Cdd:cd19118   142 WKAMVELKKTGKVKSIGVSNFSIDHLQAIIEETGVVPAVNQIEAHPLLLQDELVDYCKSKNIHITAYSPLGNNLAGLPLL 221

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2796469736  82 eiIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISilDFELSVDEMAEITSL 147
Cdd:cd19118   222 --VQHPEVKAIAAKLGKTPAQVLIAWGIQRGHSVIPKSVTPSRIRSNFE--QVELSDDEFNAVTAL 283
AKR_AKR5H1 cd19134
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ...
 2-150 3.64e-36

AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.


Pssm-ID: 381360 [Multi-domain]  Cd Length: 263  Bit Score: 126.89  E-value: 3.64e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSHFRsveprl 81
Cdd:cd19134   118 WGGLMKLREEGLARSIGVSNFTAEHLENLIDLTFFTPAVNQIELHPLLNQAELRKVNAQHGIVTQAYSPLGVGR------ 191

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2796469736  82 eIIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLNKG 150
Cdd:cd19134   192 -LLDNPAVTAIAAAHGRTPAQVLLRWSLQLGNVVISRSSNPERIASNLDVFDFELTADHMDALDGLDDG 259
AKR_AKR2B1-10 cd19113
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ...
 2-154 2.23e-35

AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.


Pssm-ID: 381339 [Multi-domain]  Cd Length: 310  Bit Score: 126.02  E-value: 2.23e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSHFRSVEPRL 81
Cdd:cd19113   146 WKALEKLVDAGKIKSIGVSNFPGALILDLLRGATIKPAVLQIEHHPYLQQPKLIEYAQKAGITITAYSSFGPQSFVELNQ 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  82 E-------IIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLNKGRYLN 154
Cdd:cd19113   226 GralntptLFEHDTIKSIAAKHNKTPAQVLLRWATQRGIAVIPKSNLPERLLQNLSVNDFDLTKEDFEEIAKLDIGLRFN 305
AKR_AKR1G1_1I cd19111
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ...
 1-150 3.16e-35

Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381337 [Multi-domain]  Cd Length: 286  Bit Score: 125.30  E-value: 3.16e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   1 MWEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTF-----SHFR 75
Cdd:cd19111   126 VWRAMEALVSEGKVKSIGLSNFNPRQINKILAYAKVKPSNLQLECHAYLQQRELRKFCNKKNIVVTAYAPLgspgrANQS 205

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2796469736  76 SVEPRLEIIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLNKG 150
Cdd:cd19111   206 LWPDQPDLLEDPTVLAIAKELDKTPAQVLLRFVLQRGTGVLPKSTNKERIEENFEVFDFELTEEHFKKLKTLDRN 280
AKR_AKR1E1-2 cd19110
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ...
 2-157 6.36e-35

AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.


Pssm-ID: 381336 [Multi-domain]  Cd Length: 301  Bit Score: 124.69  E-value: 6.36e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISD--VVPAVNQIEISPLNAQIELTKYCQDRGIAVEAmstfshFRSVEP 79
Cdd:cd19110   133 WEAMEDLVIEGLVKNIGVSNFNHEQLERLLNKPGlrVKPVTNQIECHPYLTQKKLISFCQSRNVSVTA------YRPLGG 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  80 RLE---IIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLNKGRYLNYN 156
Cdd:cd19110   207 SCEgvdLIDDPVIQRIAKKHGKSPAQILIRFQIQRNVIVIPKSVTPSRIKENIQVFDFELTEHDMDNLLSLDRNLRLATF 286


                  .
gi 2796469736 157 P 157
Cdd:cd19110   287 P 287
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
2-157 6.76e-35

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 124.03  E-value: 6.76e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSHFRSveprl 81
Cdd:PRK11565  120 WKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGGK----- 194

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2796469736  82 EIIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLNKGRYLNYNP 157
Cdd:PRK11565  195 GVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVFDFRLDKDELGEIAKLDQGKRLGPDP 270
AKR_AKR1B1-19 cd19107
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ...
 2-150 7.47e-35

AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.


Pssm-ID: 381333 [Multi-domain]  Cd Length: 307  Bit Score: 124.84  E-value: 7.47e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVV--PAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSH-----F 74
Cdd:cd19107   133 WEAMEELVDEGLVKAIGVSNFNHLQIERILNKPGLKykPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSpdrpwA 212

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2796469736  75 RSVEPRLeiIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLNKG 150
Cdd:cd19107   213 KPEDPSL--LEDPKIKEIAAKHNKTTAQVLIRFPIQRNLVVIPKSVTPERIAENFKVFDFELSSEDMATILSFNRN 286
AKR_AKR4A_4B cd19124
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ...
 2-147 7.52e-35

AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.


Pssm-ID: 381350 [Multi-domain]  Cd Length: 281  Bit Score: 123.92  E-value: 7.52e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSHFRSVEPRL 81
Cdd:cd19124   134 WEAMEECQRLGLTKAIGVSNFSCKKLQELLSFATIPPAVNQVEMNPAWQQKKLREFCKANGIHVTAYSPLGAPGTKWGSN 213

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2796469736  82 EIIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSL 147
Cdd:cd19124   214 AVMESDVLKEIAAAKGKTVAQVSLRWVYEQGVSLVVKSFNKERMKQNLDIFDWELTEEDLEKISEI 279
AKR_AKR1I_CgAKR1 cd19155
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ...
 1-150 4.35e-34

Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381381 [Multi-domain]  Cd Length: 307  Bit Score: 122.63  E-value: 4.35e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   1 MWEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMS--------TFS 72
Cdd:cd19155   142 IWKAMEAQVDQGLTRSIGLSNFNREQMARILKNARIKPANLQVELHVYLQQKDLVDFCSTHSITVTAYAplgspgaaHFS 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  73 HFRSVEPR--LEIIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLNKG 150
Cdd:cd19155   222 PGTGSPSGssPDLLQDPVVKAIAERHGKSPAQVLLRWLMQRGVVVIPKSTNAARIKENFQVFDFELTEADMAKLSSLDKN 301
AKR_AKR3D1 cd19121
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ...
 2-135 6.95e-32

AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.


Pssm-ID: 381347 [Multi-domain]  Cd Length: 279  Bit Score: 116.48  E-value: 6.95e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSHFRSveprl 81
Cdd:cd19121   141 WKQMEKVLKTGKTKAIGVSNYSIPYLEELLKHATVVPAVNQVENHPYLPQQELVDFCKEKGILIEAYSPLGSTGS----- 215

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2796469736  82 EIIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFE 135
Cdd:cd19121   216 PLISDEPVVEIAKKHNVGPGTVLISYQVARGAVVLPKSVTPDRIKSNLEIIDLD 269
AKR_AKR3C1 cd19119
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ...
 1-131 1.43e-31

Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).


Pssm-ID: 381345 [Multi-domain]  Cd Length: 294  Bit Score: 115.67  E-value: 1.43e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   1 MWEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSHFRSvepr 80
Cdd:cd19119   146 TYKQLEKIYLDGRAKAIGVSNYSIVYLERLIKECKVVPAVNQVELHPHLPQMDLRDFCFKHGILVTAYSPLGSHGA---- 221

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2796469736  81 lEIIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISI 131
Cdd:cd19119   222 -PNLKNPLVKKIAEKYNVSTGDILISYHVRQGVIVLPKSLKPVRIVSNGKI 271
AKR_AKR1D1-3 cd19109
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ...
 2-152 1.55e-31

AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.


Pssm-ID: 381335 [Multi-domain]  Cd Length: 308  Bit Score: 116.05  E-value: 1.55e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVV--PAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSHFR---- 75
Cdd:cd19109   137 WEALEACKDAGLVKSIGVSNFNRRQLELILNKPGLKhkPVSNQVECHPYFTQPKLLEFCQQHDIVIVAYSPLGTCRdpiw 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  76 ---SVEPRLEiieHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLNKG-R 151
Cdd:cd19109   217 vnvSSPPLLE---DPLLNSIGKKYNKTAAQVVLRFNIQRGVVVIPKSFNPERIKENFQIFDFSLTEEEMKDIEALNKNvR 293


                  .
gi 2796469736 152 Y 152
Cdd:cd19109   294 Y 294
AKR_AKR3F1-like cd19072
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ...
 2-144 6.48e-31

Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381298 [Multi-domain]  Cd Length: 263  Bit Score: 113.48  E-value: 6.48e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPH-IEALSEISDVVPAVNQIEISPLNAQIE--LTKYCQDRGIAVEAMSTFSH-FRSV 77
Cdd:cd19072   120 LRAMEELVEEGKIRYIGVSNFSLEElEEAQSYLKKGPIVANQVEYNLFDREEEsgLLPYCQKNGIAIIAYSPLEKgKLSN 199

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2796469736  78 EPRLEIIEHplilaIAKKHGKSTVQIVLRWLVQR-GIIVIPKTWNMVHLKENISILDFELSVDEMAEI 144
Cdd:cd19072   200 AKGSPLLDE-----IAKKYGKTPAQIALNWLISKpNVIAIPKASNIEHLEENAGALGWELSEEDLQRL 262
AKR_AKR3F2 cd19139
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ...
 9-147 2.19e-30

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381365 [Multi-domain]  Cd Length: 248  Bit Score: 111.68  E-value: 2.19e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   9 YKEGRIRAIGVSNFLQPHI-EALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSHFRsveprleIIEHP 87
Cdd:cd19139   116 KEQGLTRHIGVSNFTIALLdEAIAVVGAGAIATNQIELSPYLQNRKLVAHCKQHGIHVTSYMTLAYGK-------VLDDP 188

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  88 LILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSL 147
Cdd:cd19139   189 VLAAIAERHGATPAQIALAWAMARGYAVIPSSTKREHLRSNLLALDLTLDADDMAAIAAL 248
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 2-148 2.30e-28

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 107.40  E-value: 2.30e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIE--LTKYCQDRGIAVEAMSTFSH------ 73
Cdd:pfam00248 120 WDALEELKKEGKIRAIGVSNFDAEQIEKALTKGKIPIVAVQVEYNLLRRRQEeeLLEYCKKNGIPLIAYSPLGGglltgk 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  74 -------FRSVEPRLEIIEHPLIL-------AIAKKHGKSTVQIVLRWLVQ--RGIIVIPKTWNMVHLKENISILDFELS 137
Cdd:pfam00248 200 ytrdpdkGPGERRRLLKKGTPLNLealealeEIAKEHGVSPAQVALRWALSkpGVTIPIPGASNPEQLEDNLGALEFPLS 279

                         170
                  ....*....|.
gi 2796469736 138 VDEMAEITSLN 148
Cdd:pfam00248 280 DEEVARIDELL 290
AKR_AKR2C1 cd19114
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ...
 2-154 7.01e-28

AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.


Pssm-ID: 381340 [Multi-domain]  Cd Length: 302  Bit Score: 106.49  E-value: 7.01e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTF---------- 71
Cdd:cd19114   139 WREMEKLVDAGLVRNIGIANFNVQLILDLLTYAKIKPAVLQIEHHPYLQQKRLIDWAKKQGIQITAYSSFgnavytkvtk 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  72 --SHFRSveprleIIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLNK 149
Cdd:cd19114   219 hlKHFTN------LLEHPVVKKLADKHKRDTGQVLLRWAVQRNITVIPKSVNVERMKTNLDITSYKLDEEDMEALYELEA 292


                  ....*
gi 2796469736 150 GRYLN 154
Cdd:cd19114   293 NARFN 297
AKR_YeaE cd19138
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ...
 3-144 9.72e-28

Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381364 [Multi-domain]  Cd Length: 266  Bit Score: 105.02  E-value: 9.72e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   3 EVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVP-AVNQIE--ISPLNAQIELTKYCQDRGIAVEAMSTFSHFRsvEP 79
Cdd:cd19138   122 AAMEELKKEGKIRAWGVSNFDTDDMEELWAVPGGGNcAANQVLynLGSRGIEYDLLPWCREHGVPVMAYSPLAQGG--LL 199

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2796469736  80 RLEIIEHPLILAIAKKHGKSTVQIVLRWLV-QRGIIVIPKTWNMVHLKENISILDFELSVDEMAEI 144
Cdd:cd19138   200 RRGLLENPTLKEIAARHGATPAQVALAWVLrDGNVIAIPKSGSPEHARENAAAADLELTEEDLAEL 265
AKR_BaDH-like cd19129
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ...
 2-165 1.57e-26

Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.


Pssm-ID: 381355 [Multi-domain]  Cd Length: 295  Bit Score: 102.54  E-value: 1.57e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFlqpHIEALSEISDVV---PAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSHfrSVE 78
Cdd:cd19129   136 WRAMERLVDEGRCKAIGLSDV---SLEKLREIFEAArikPAVVQVESHPYLPEWELLDFCKNHGIVLQAFAPLGH--GME 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  79 PRLeiIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENisildFELSV---DEMAEITSLNKGRYlNY 155
Cdd:cd19129   211 PKL--LEDPVITAIARRVNKTPAQVLLAWAIQRGTALLTTSKTPSRIREN-----FDISTlpeDAMREINEGIKTRY-RF 282

                         170
                  ....*....|
gi 2796469736 156 NPfVAQRGLP 165
Cdd:cd19129   283 NS-VVETGVP 291
AKR_AKR1C1-35 cd19108
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ...
 2-153 7.88e-26

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.


Pssm-ID: 381334 [Multi-domain]  Cd Length: 303  Bit Score: 100.77  E-value: 7.88e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVV--PAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTF-SHF--RS 76
Cdd:cd19108   143 WEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKykPVCNQVECHPYLNQSKLLDFCKSKDIVLVAYSALgSQRdkEW 222

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2796469736  77 VEPRLEII-EHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLNKG-RYL 153
Cdd:cd19108   223 VDQNSPVLlEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSFNEKRIKENLQVFEFQLTSEDMKALDGLNRNlRYL 301
dkgB PRK11172
2,5-didehydrogluconate reductase DkgB;
10-150 2.00e-25

2,5-didehydrogluconate reductase DkgB;


Pssm-ID: 183012 [Multi-domain]  Cd Length: 267  Bit Score: 98.94  E-value: 2.00e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  10 KEGRIRAIGVSNF----LQPHIEAL--SEIsdvvpAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSHFRsveprleI 83
Cdd:PRK11172  119 KQGLTREIGISNFtialMKQAIAAVgaENI-----ATNQIELSPYLQNRKVVAFAKEHGIHVTSYMTLAYGK-------V 186

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2796469736  84 IEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISILDFELSVDEMAEITSLNKG 150
Cdd:PRK11172  187 LKDPVIARIAAKHNATPAQVILAWAMQLGYSVIPSSTKRENLASNLLAQDLQLDAEDMAAIAALDRN 253
AKR_AKR3E1 cd19122
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ...
 2-143 1.47e-24

AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.


Pssm-ID: 381348 [Multi-domain]  Cd Length: 291  Bit Score: 97.31  E-value: 1.47e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSHFRSVEPRL 81
Cdd:cd19122   145 WRAMEEIYESGKAKAIGVSNWTIPGLKKLLSFAKVKPHVNQIEIHPFLPNEELVDYCFSNDILPEAYSPLGSQNQVPSTG 224

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2796469736  82 E-IIEHPLILAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENISIL-----DFElSVDEMAE 143
Cdd:cd19122   225 ErVSENPTLNEVAEKGGYSLAQVLIAWGLRRGYVVLPKSSTPSRIESNFKSIelsdeDFE-AINQVAK 291
AKR_AKR11B1-like cd19084
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ...
 2-144 2.60e-23

AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381310 [Multi-domain]  Cd Length: 296  Bit Score: 94.13  E-value: 2.60e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVpaVNQIEISPLNAQIE--LTKYCQDRGIAVEAMSTFSH------ 73
Cdd:cd19084   127 AEALEKLKKEGKIRYIGVSNFSVEQLEEARKYGPIV--SLQPPYSMLEREIEeeLLPYCRENGIGVLPYGPLAQglltgk 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  74 -----------FRSVEPR---------LEIIEHplILAIAKKHGKSTVQIVLRWLVQR--GIIVIPKTWNMVHLKENISI 131
Cdd:cd19084   205 ykkeptfppddRRSRFPFfrgenfeknLEIVDK--LKEIAEKYGKSLAQLAIAWTLAQpgVTSAIVGAKNPEQLEENAGA 282

                         170
                  ....*....|...
gi 2796469736 132 LDFELSVDEMAEI 144
Cdd:cd19084   283 LDWELTEEELKEI 295
AKR_GlAR-like cd19128
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ...
 2-147 3.81e-23

Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.


Pssm-ID: 381354 [Multi-domain]  Cd Length: 277  Bit Score: 93.36  E-value: 3.81e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFSHfRSVEPRL 81
Cdd:cd19128   130 WRAMEQCVDEKLTKNIGVSNYSTKLLTDLLNYCKIKPFMNQIECHPYFQNDKLIKFCIENNIHVTAYRPLGG-SYGDGNL 208

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2796469736  82 EIIEHPLILAIAKKHGKSTVQIVLRWLVQR---GIIVIPKTWNMVHLKENISILDFELSVDEMAEITSL 147
Cdd:cd19128   209 TFLNDSELKALATKYNTTPPQVIIAWHLQKwpkNYSVIPKSANKSRCQQNFDINDLALTKEDMDAINTL 277
AKR_AtPLR-like cd19093
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ...
 2-144 4.87e-23

Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.


Pssm-ID: 381319 [Multi-domain]  Cd Length: 293  Bit Score: 93.06  E-value: 4.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNF----LQPHIEALSEiSDVVPAVNQIEISPLN---AQIELTKYCQDRGIAVEAMS----- 69
Cdd:cd19093   124 MDGLADAVEEGLVRAVGVSNYsadqLRRAHKALKE-RGVPLASNQVEYSLLYrdpEQNGLLPACDELGITLIAYSplaqg 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  70 --------------------TFSHFRSVEPRLEIIEhplilAIAKKHGKSTVQIVLRWLVQRGIIVIPKTWNMVHLKENI 129
Cdd:cd19093   203 lltgkyspenpppggrrrlfGRKNLEKVQPLLDALE-----EIAEKYGKTPAQVALNWLIAKGVVPIPGAKNAEQAEENA 277

                         170
                  ....*....|....*
gi 2796469736 130 SILDFELSVDEMAEI 144
Cdd:cd19093   278 GALGWRLSEEEVAEL 292
PdxI COG0667
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ...
 2-147 3.90e-21

Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440431 [Multi-domain]  Cd Length: 316  Bit Score: 88.31  E-value: 3.90e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVP--AVNQIEISPLNAQIE--LTKYCQDRGIAVEAMSTF------ 71
Cdd:COG0667   135 LGALDELVREGKIRYIGVSNYSAEQLRRALAIAEGLPpiVAVQNEYSLLDRSAEeeLLPAARELGVGVLAYSPLaggllt 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  72 ----------------SHFRSVEPRLEIIEH-PLILAIAKKHGKSTVQIVLRWLVQRG--IIVIPKTWNMVHLKENISIL 132
Cdd:COG0667   215 gkyrrgatfpegdraaTNFVQGYLTERNLALvDALRAIAAEHGVTPAQLALAWLLAQPgvTSVIPGARSPEQLEENLAAA 294

                         170
                  ....*....|....*
gi 2796469736 133 DFELSVDEMAEITSL 147
Cdd:COG0667   295 DLELSAEDLAALDAA 309
AKR_AKR3F1 cd19137
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ...
 5-141 7.98e-21

Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381363 [Multi-domain]  Cd Length: 260  Bit Score: 86.86  E-value: 7.98e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   5 LEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQIE---LTKYCQDRGIAVEAMSTFShfRSVEPRL 81
Cdd:cd19137   123 MAEGVRQGLIRYIGVSNFNRRLLEEAISKSQTPIVCNQVKYNLEDRDPErdgLLEYCQKNGITVVAYSPLR--RGLEKTN 200

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2796469736  82 EIIEHplilaIAKKHGKSTVQIVLRWLVQR-GIIVIPKTWNMVHLKENISILDFELSVDEM 141
Cdd:cd19137   201 RTLEE-----IAKNYGKTIAQIALAWLIQKpNVVAIPKAGRVEHLKENLKATEIKLSEEEM 256
AKR_AKR11B3 cd19085
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ...
 3-146 1.52e-18

Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.


Pssm-ID: 381311 [Multi-domain]  Cd Length: 292  Bit Score: 81.09  E-value: 1.52e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   3 EVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVpaVNQIEISPLNAQIE--LTKYCQDRGIAVEAMSTFS-------- 72
Cdd:cd19085   117 EALEKLKEEGKIRAIGVSNFGPAQLEEALDAGRID--SNQLPYNLLWRAIEyeILPFCREHGIGVLAYSPLAqglltgkf 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  73 --------------HFRSVEPRLEIIEHPLILA---IAKKHGKSTVQIVLRWLVQRGII--VIPKTWNMVHLKENISILD 133
Cdd:cd19085   195 ssaedfppgdartrLFRHFEPGAEEETFEALEKlkeIADELGVTMAQLALAWVLQQPGVtsVIVGARNPEQLEENAAAVD 274

                         170
                  ....*....|...
gi 2796469736 134 FELSVDEMAEITS 146
Cdd:cd19085   275 LELSPSVLERLDE 287
AKR_AKR13B1 cd19088
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ...
 3-137 5.96e-18

AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.


Pssm-ID: 381314 [Multi-domain]  Cd Length: 256  Bit Score: 78.80  E-value: 5.96e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   3 EVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVpAVnQIEISPLNAQIE-LTKYCQDRGIAVEAMSTFSHFRSVEPRl 81
Cdd:cd19088   127 GALAELQDEGLIRHIGLSNVTVAQIEEARAIVRIV-SV-QNRYNLANRDDEgVLDYCEAAGIAFIPWFPLGGGDLAQPG- 203

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2796469736  82 eiiehPLILAIAKKHGKSTVQIVLRWLVQRG--IIVIPKTWNMVHLKENISILDFELS 137
Cdd:cd19088   204 -----GLLAEVAARLGATPAQVALAWLLARSpvMLPIPGTSSVEHLEENLAAAGLRLS 256
AKR_AKR8A1-2 cd19077
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ...
 3-144 2.46e-16

AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).


Pssm-ID: 381303 [Multi-domain]  Cd Length: 302  Bit Score: 75.35  E-value: 2.46e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   3 EVLEKFYKEGRIRAIGVSnflQPHIEALSEISDVVP-AVNQIEISPLNAQIE---LTKYCQDRGIAVEAMSTFSH----- 73
Cdd:cd19077   132 KALKELVKEGKIRGIGLS---EVSAETIRRAHAVHPiAAVEVEYSLFSREIEengVLETCAELGIPIIAYSPLGRglltg 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  74 ------------FRSVEPRL--EIIEHPLILA-----IAKKHGKSTVQIVLRWLVQRG---IIVIPKTWNMVHLKENISI 131
Cdd:cd19077   209 riksladipegdFRRHLDRFngENFEKNLKLVdalqeLAEKKGCTPAQLALAWILAQSgpkIIPIPGSTTLERVEENLKA 288

                         170
                  ....*....|...
gi 2796469736 132 LDFELSVDEMAEI 144
Cdd:cd19077   289 ANVELTDEELKEI 301
AKR_AKR13A1 cd19144
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ...
 5-144 2.90e-16

AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.


Pssm-ID: 381370 [Multi-domain]  Cd Length: 323  Bit Score: 75.17  E-value: 2.90e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   5 LEKFYKEGRIRAIGVSnflQPHIEALSEISDVVP--AVnQIEISPL-----NAQIELTKYCQDRGIAVEAMSTFSH---- 73
Cdd:cd19144   141 MAELVQEGKIKHIGLS---ECSAETLRRAHAVHPiaAV-QIEYSPFsldieRPEIGVLDTCRELGVAIVAYSPLGRgflt 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  74 -------------FRSVEPR---------LEIIEHplILAIAKKHGKSTVQIVLRWLVQRG--IIVIPKTWNMVHLKENI 129
Cdd:cd19144   217 gairspddfeegdFRRMAPRfqaenfpknLELVDK--IKAIAKKKNVTAGQLTLAWLLAQGddIIPIPGTTKLKRLEENL 294

                         170
                  ....*....|....*
gi 2796469736 130 SILDFELSVDEMAEI 144
Cdd:cd19144   295 GALKVKLTEEEEKEI 309
AKR_BsYcsN_EcYdhF-like cd19092
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ...
 3-144 1.37e-14

Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.


Pssm-ID: 381318 [Multi-domain]  Cd Length: 287  Bit Score: 70.28  E-value: 1.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   3 EVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIEISPLNAQI---ELTKYCQDRGIAVEAMST------FSH 73
Cdd:cd19092   134 EAFDELVKSGKVRYFGVSNFTPSQIELLQSYLDQPLVTNQIELSLLHTEAiddGTLDYCQLLDITPMAWSPlgggrlFGG 213

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2796469736  74 FRSVEPRLeiieHPLILAIAKKHGKSTVQIVLRWLVQR--GIIVIPKTWNMVHLKENISILDFELSVDEMAEI 144
Cdd:cd19092   214 FDERFQRL----RAALEELAEEYGVTIEAIALAWLLRHpaRIQPILGTTNPERIRSAVKALDIELTREEWYEI 282
AKR_AKR13A_13D cd19076
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ...
 2-144 8.54e-14

AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381302 [Multi-domain]  Cd Length: 303  Bit Score: 68.01  E-value: 8.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGvsnflqphieaLSEISD--------VVP--AVnQIEISPL--NAQIELTKYCQDRGIAVEAMS 69
Cdd:cd19076   135 VGAMAELVEEGKVRYIG-----------LSEASAdtirrahaVHPitAV-QSEYSLWtrDIEDEVLPTCRELGIGFVAYS 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  70 TFSH-----------------FRSVEPR---------LEIIEHplILAIAKKHGKSTVQIVLRWLVQRG--IIVIPKTWN 121
Cdd:cd19076   203 PLGRgfltgaikspedlpeddFRRNNPRfqgenfdknLKLVEK--LEAIAAEKGCTPAQLALAWVLAQGddIVPIPGTKR 280

                         170       180
                  ....*....|....*....|...
gi 2796469736 122 MVHLKENISILDFELSVDEMAEI 144
Cdd:cd19076   281 IKYLEENVGALDVVLTPEELAEI 303
AKR_SF cd06660
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
 2-130 2.03e-13

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


Pssm-ID: 381296 [Multi-domain]  Cd Length: 232  Bit Score: 66.39  E-value: 2.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISD----VVPAVNQIEISPLNAQI---ELTKYCQDRGIAVEAMStfshf 74
Cdd:cd06660   120 LEALNELVREGKIRYIGVSNWSAERLAEALAYAKahglPGFAAVQPQYSLLDRSPmeeELLDWAEENGLPLLAYS----- 194

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2796469736  75 rsveprleiiehPLilaiakkhGKSTVQIVLRWLVQR--GIIVIPKTWNMVHLKENIS 130
Cdd:cd06660   195 ------------PL--------ARGPAQLALAWLLSQpfVTVPIVGARSPEQLEENLA 232
AKR_AKR11B2 cd19149
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ...
 2-146 3.14e-13

Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381375 [Multi-domain]  Cd Length: 315  Bit Score: 66.53  E-value: 3.14e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVvpAVNQIEISPLNAQIE--LTKYCQDRGIAVEAMS---------- 69
Cdd:cd19149   145 MEALEELKRQGKIRAIGASNVSVEQIKEYVKAGQL--DIIQEKYSMLDRGIEkeLLPYCKKNNIAFQAYSpleqglltgk 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  70 -----TFSH--FRSVEPRLEIIEHPLILA-------IAKKHGKSTVQIVLRW-LVQRGII-VIPKTWNMVHLKENISILD 133
Cdd:cd19149   223 itpdrEFDAgdARSGIPWFSPENREKVLAllekwkpLCEKYGCTLAQLVIAWtLAQPGITsALCGARKPEQAEENAKAGD 302

                         170
                  ....*....|...
gi 2796469736 134 FELSVDEMAEITS 146
Cdd:cd19149   303 IRLSAEDIATMRS 315
AKR_unchar cd19102
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 2-147 9.95e-12

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381328 [Multi-domain]  Cd Length: 302  Bit Score: 62.31  E-value: 9.95e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVvpAVNQIEISPLNAQIE--LTKYCQDRGIAVEAMS---------- 69
Cdd:cd19102   128 WGALAELKEEGKVRAIGVSNFSVDQMKRCQAIHPI--ASLQPPYSLLRRGIEaeILPFCAEHGIGVIVYSpmqsglltgk 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  70 ---------------TFSHFRSvEPR----LEIIEHplILAIAKKHGKSTVQIVLRWLVQRGII--VIPKTWNMVHLKEN 128
Cdd:cd19102   206 mtpervaslpaddwrRRSPFFQ-EPNlarnLALVDA--LRPIAERHGRTVAQLAIAWVLRRPEVtsAIVGARRPDQIDET 282

                         170
                  ....*....|....*....
gi 2796469736 129 ISILDFELSVDEMAEITSL 147
Cdd:cd19102   283 VGAADLRLTPEELAEIEAL 301
AKR_AKR13C1_2 cd19078
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ...
 3-146 2.59e-11

AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.


Pssm-ID: 381304 [Multi-domain]  Cd Length: 301  Bit Score: 61.09  E-value: 2.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   3 EVLEKFYKEGRIRAIGvsnflqphieaLSEISdvvpaVNQI----EISPLNA------------QIELTKYCQDRGI--- 63
Cdd:cd19078   130 GTMKELIKEGKIRHWG-----------LSEAG-----VETIrrahAVCPVTAvqseysmmwrepEKEVLPTLEELGIgfv 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  64 ------------AVEAMSTF--SHFRSVEPR---------LEIIEhpLILAIAKKHGKSTVQIVLRWLV-QRGIIV-IPK 118
Cdd:cd19078   194 pfsplgkgfltgKIDENTKFdeGDDRASLPRftpealeanQALVD--LLKEFAEEKGATPAQIALAWLLaKKPWIVpIPG 271

                         170       180
                  ....*....|....*....|....*...
gi 2796469736 119 TWNMVHLKENISILDFELSVDEMAEITS 146
Cdd:cd19078   272 TTKLSRLEENIGAADIELTPEELREIED 299
AKR_PA4992-like cd19095
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ...
 3-129 2.74e-11

Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381321 [Multi-domain]  Cd Length: 253  Bit Score: 60.71  E-value: 2.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   3 EVLEKFYKEGRIRAIGVSNFLQPHIEAL-SEISDVVpavnQIEISPLN-AQIELTKYCQDRGIAVEAMSTFSH---FRSV 77
Cdd:cd19095   121 ETLEDLKAAGKVRYIGVSGDGEELEAAIaSGVFDVV----QLPYNVLDrEEEELLPLAAEAGLGVIVNRPLANgrlRRRV 196

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2796469736  78 EPRLEIIEHPLILAIAKKHG-KSTVQIVLRWLV-QRGI-IVIPKTWNMVHLKENI 129
Cdd:cd19095   197 RRRPLYADYARRPEFAAEIGgATWAQAALRFVLsHPGVsSAIVGTTNPEHLEENL 251
AKR_AKR13D1 cd19145
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ...
 5-144 3.91e-10

AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381371 [Multi-domain]  Cd Length: 304  Bit Score: 57.83  E-value: 3.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   5 LEKFYKEGRIRAIGVSnflqphiEALSEISDVVPAVN-----QIEISPLNAQIE--LTKYCQDRGIAVEAMSTF------ 71
Cdd:cd19145   139 LKKLVEEGKIKYIGLS-------EASADTIRRAHAVHpitavQLEWSLWTRDIEeeIIPTCRELGIGIVPYSPLgrgffa 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  72 -----------SHFRSVEPRL--EIIEHPLIL-----AIAKKHGKSTVQIVLRWLVQRG--IIVIPKTWNMVHLKENISI 131
Cdd:cd19145   212 gkakleellenSDVRKSHPRFqgENLEKNKVLyerveALAKKKGCTPAQLALAWVLHQGedVVPIPGTTKIKNLNQNIGA 291

                         170
                  ....*....|...
gi 2796469736 132 LDFELSVDEMAEI 144
Cdd:cd19145   292 LSVKLTKEDLKEI 304
AKR_unchar cd19101
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 10-146 1.45e-09

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381327 [Multi-domain]  Cd Length: 304  Bit Score: 56.06  E-value: 1.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  10 KEGRIRAIGVSNFLQPHieaLSEISDVVPAV--NQIEISPLN--AQIELTKYCQDRGIAVEAMSTFS------HFRSV-E 78
Cdd:cd19101   133 EEGKIRHLGLTNFDTER---LREILDAGVPIvsNQVQYSLLDrrPENGMAALCEDHGIKLLAYGTLAggllseKYLGVpE 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  79 PRLEIIEHP-----------------------LILAIAKKHGKSTVQIVLRWLVQR----GIIVipKTWNMVHLKENISI 131
Cdd:cd19101   210 PTGPALETRslqkyklmidewggwdlfqellrTLKAIADKHGVSIANVAVRWVLDQpgvaGVIV--GARNSEHIDDNVRA 287

                         170
                  ....*....|....*
gi 2796469736 132 LDFELSVDEMAEITS 146
Cdd:cd19101   288 FSFRLDDEDRAAIDA 302
AKR_AKR11A1_11D1 cd19083
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ...
 5-147 4.19e-09

AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).


Pssm-ID: 381309 [Multi-domain]  Cd Length: 307  Bit Score: 54.73  E-value: 4.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   5 LEKFYKEGRIRAIGVSNFlqpHIEALSEIS-----DVVpavnQIEISPLNAQIE--LTKYCQDRGIAV------------ 65
Cdd:cd19083   138 LQELKDEGKIRAIGVSNF---SLEQLKEANkdgyvDVL----QGEYNLLQREAEedILPYCVENNISFipyfplasglla 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  66 ---EAMSTFS--HFRSVEPRL--EIIEHPL-----ILAIAKKHGKSTVQIVLRWLVQRGII--VIPKTWNMVHLKENISI 131
Cdd:cd19083   211 gkyTKDTKFPdnDLRNDKPLFkgERFSENLdkvdkLKSIADEKGVTVAHLALAWYLTRPAIdvVIPGAKRAEQVIDNLKA 290

                         170
                  ....*....|....*.
gi 2796469736 132 LDFELSVDEMAEITSL 147
Cdd:cd19083   291 LDVTLTEEEIAFIDAL 306
AKR_Tas-like cd19094
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ...
 3-144 5.61e-09

Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.


Pssm-ID: 381320 [Multi-domain]  Cd Length: 328  Bit Score: 54.49  E-value: 5.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   3 EVLEKFYKEGRIRAIGVSN--------FLQ-------PHI---------------EALSEISdvvpAVNQIEI---SPLn 49
Cdd:cd19094   151 EALGELVKAGKIRHIGLSNetpwgvmkFLElaeqlglPRIvsiqnpysllnrnfeEGLAEAC----HRENVGLlaySPL- 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  50 AQIELT-KYCQDRGIAVEA-MSTFSHF-------RSVEPRLEIIEhplilaIAKKHGKSTVQIVLRWLVQR---GIIVIP 117
Cdd:cd19094   226 AGGVLTgKYLDGAARPEGGrLNLFPGYmaryrspQALEAVAEYVK------LARKHGLSPAQLALAWVRSRpfvTSTIIG 299

                         170       180
                  ....*....|....*....|....*..
gi 2796469736 118 KTwNMVHLKENISILDFELSVDEMAEI 144
Cdd:cd19094   300 AT-TLEQLKENIDAFDVPLSDELLAEI 325
AKR_PsAKR cd19091
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ...
 3-147 6.54e-09

Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.


Pssm-ID: 381317 [Multi-domain]  Cd Length: 319  Bit Score: 54.16  E-value: 6.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   3 EVLEKFYKEGRIRAIGVSNFLQPHIEALSEISD----VVPAVNQIEISPLNAQIE--LTKYCQDRGIAVEAMSTFS---- 72
Cdd:cd19091   141 RALDDLVRQGKVRYIGVSNFSAWQIMKALGISErrglARFVALQAYYSLLGRDLEheLMPLALDQGVGLLVWSPLAggll 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  73 --HFRSVEPRLE---------------------IIEhpLILAIAKKHGKSTVQIVLRWLVQRGII--VIPKTWNMVHLKE 127
Cdd:cd19091   221 sgKYRRGQPAPEgsrlrrtgfdfppvdrergydVVD--ALREIAKETGATPAQVALAWLLSRPTVssVIIGARNEEQLED 298

                         170       180
                  ....*....|....*....|
gi 2796469736 128 NISILDFELSVDEMAEITSL 147
Cdd:cd19091   299 NLGAAGLSLTPEEIARLDKV 318
AKR_AKR11B1 cd19148
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ...
 3-144 2.17e-08

Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381374 [Multi-domain]  Cd Length: 302  Bit Score: 52.69  E-value: 2.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   3 EVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVvpAVNQieiSPLN---AQIE--LTKYCQDRGIAVEA---------- 67
Cdd:cd19148   130 EALKELLDEGKIRAIGVSNFSPEQMETFRKVAPL--HTVQ---PPYNlfeREIEkdVLPYARKHNIVTLAygalcrglls 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  68 --MSTFSHF-----RSVEPR---------LEIIEHplILAIAKKH-GKSTVQIVLRWLVQRGIIVIpKTWNM---VHLKE 127
Cdd:cd19148   205 gkMTKDTKFegddlRRTDPKfqeprfsqyLAAVEE--LDKLAQERyGKSVIHLAVRWLLDQPGVSI-ALWGArkpEQLDA 281

                         170
                  ....*....|....*..
gi 2796469736 128 NISILDFELSVDEMAEI 144
Cdd:cd19148   282 VDEVFGWSLNDEDMKEI 298
AKR_EcYajO-like cd19079
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ...
 3-144 4.38e-08

Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381305 [Multi-domain]  Cd Length: 312  Bit Score: 51.82  E-value: 4.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   3 EVLEKFYKEGRIRAIGVSNFLQPHIEALSEISD------VVPAVNQieispLNA-----QIELTKYCQDRGIAVEAMS-- 69
Cdd:cd19079   139 EALHDVVKSGKVRYIGASSMYAWQFAKALHLAEkngwtkFVSMQNH-----YNLlyreeEREMIPLCEEEGIGVIPWSpl 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  70 ----------------------TFSHFRSVEPR-LEIIEHplILAIAKKHGKSTVQIVLRWLVQRGIIVIP-----Ktwn 121
Cdd:cd19079   214 argrlarpwgdtterrrsttdtAKLKYDYFTEAdKEIVDR--VEEVAKERGVSMAQVALAWLLSKPGVTAPivgatK--- 288

                         170       180
                  ....*....|....*....|...
gi 2796469736 122 MVHLKENISILDFELSVDEMAEI 144
Cdd:cd19079   289 LEHLEDAVAALDIKLSEEEIKYL 311
AKR_AKR9A_9B cd19080
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ...
 12-144 2.65e-07

AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.


Pssm-ID: 381306 [Multi-domain]  Cd Length: 307  Bit Score: 49.53  E-value: 2.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  12 GRIRAIGVSNFlqP-----HIEALSEISDVVPAVN-QIEISPLNAQIE--LTKYCQDRGIAVEAMSTFS-------HFRS 76
Cdd:cd19080   143 GKVLYVGISDT--PawvvaRANTLAELRGWSPFVAlQIEYSLLERTPEreLLPMARALGLGVTPWSPLGgglltgkYQRG 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  77 VEPRL-----------EIIEHPL-----ILAIAKKHGKSTVQIVLRWLVQRGIIVIP----KTwnMVHLKENISILDFEL 136
Cdd:cd19080   221 EEGRAgeakgvtvgfgKLTERNWaivdvVAAVAEELGRSAAQVALAWVRQKPGVVIPiigaRT--LEQLKDNLGALDLTL 298


                  ....*...
gi 2796469736 137 SVDEMAEI 144
Cdd:cd19080   299 SPEQLARL 306
AKR_unchar cd19105
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 3-132 1.34e-06

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381331 [Multi-domain]  Cd Length: 250  Bit Score: 47.19  E-value: 1.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   3 EVLEKFYKEGRIRAIGVS------NFLQPHIEalSEISDVVpavnQIEISPLNAQIELT---KYCQDRGIAVEAMSTFSH 73
Cdd:cd19105   125 EALEKLKKEGKVRFIGFSthdnmaEVLQAAIE--SGWFDVI----MVAYNFLNQPAELEealAAAAEKGIGVVAMKTLAG 198

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2796469736  74 frsveprleIIEHPLILAIAKKHGKSTVQIVLRWLVQRGII--VIPKTWNMVHLKENISIL 132
Cdd:cd19105   199 ---------GYLQPALLSVLKAKGFSLPQAALKWVLSNPRVdtVVPGMRNFAELEENLAAA 250
PRK10376 PRK10376
putative oxidoreductase; Provisional
 3-148 1.77e-06

putative oxidoreductase; Provisional


Pssm-ID: 236676 [Multi-domain]  Cd Length: 290  Bit Score: 46.89  E-value: 1.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   3 EVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVVPAVNQIE---------ISPLNAQieltkycqdrGIAVEA---MST 70
Cdd:PRK10376  148 TVLAELQRQGLVRHIGLSNVTPTQVAEARKIAEIVCVQNHYNlahraddalIDALARD----------GIAYVPffpLGG 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  71 FSHFRSVEprleiiehplILAIAKKHGKSTVQIVLRWLVQRG--IIVIPKTWNMVHLKENISILDFELSVDEMAEITSLN 148
Cdd:PRK10376  218 FTPLQSST----------LSDVAASLGATPMQVALAWLLQRSpnILLIPGTSSVAHLRENLAAAELVLSEEVLAELDGIA 287
AKR_AKR11C1 cd19086
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ...
 2-65 3.96e-06

AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.


Pssm-ID: 381312 [Multi-domain]  Cd Length: 238  Bit Score: 45.93  E-value: 3.96e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSnfLQPHIEALSEISDVVPAVNQIEISPLN--AQIELTKYCQDRGIAV 65
Cdd:cd19086   127 FEALEKLKQEGKIRAYGVS--VGDPEEALAALRRGGIDVVQVIYNLLDqrPEEELFPLAEEHGVGV 190
AKR_Fe-S_oxidoreductase cd19096
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ...
 1-133 1.26e-05

Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381322 [Multi-domain]  Cd Length: 255  Bit Score: 44.47  E-value: 1.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   1 MWEVLEKFYKEGRIRAIGVSNFLQPhiEALSEISDVVP-AVNQIEISPLN----AQIELTKYCQDRGIAVEAMstfshfr 75
Cdd:cd19096   120 LLEFLEKAKKEGLIRHIGFSFHDSP--ELLKEILDSYDfDFVQLQYNYLDqenqAGRPGIEYAAKKGMGVIIM------- 190

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2796469736  76 svEP-----RLEIIEHplILAIAKKHGKSTVQIVLRWLV-QRGIIVI---PKtwNMVHLKENISILD 133
Cdd:cd19096   191 --EPlkgggLANNPPE--ALAILCGAPLSPAEWALRFLLsHPEVTTVlsgMS--TPEQLDENIAAAD 251
AKR_AKR10A1_2 cd19082
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ...
 3-133 1.52e-05

AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.


Pssm-ID: 381308 [Multi-domain]  Cd Length: 291  Bit Score: 44.47  E-value: 1.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   3 EVLEKFYKEGRIRAIGVSNFLQPHIEALSEISDVV----PAVNQIEIS-------PLNAQI------ELTKYCQDRGIAV 65
Cdd:cd19082   125 DTLNELVRAGKIRAFGASNWSTERIAEANAYAKAHglpgFAASSPQWSlarpnepPWPGPTlvamdeEMRAWHEENQLPV 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  66 EAMST-----FSHFRSVEP-----------------RLEIIEhplilAIAKKHGKSTVQIVLRWLVQRGIIVIP--KTWN 121
Cdd:cd19082   205 FAYSSqargfFSKRAAGGAeddselrrvyyseenfeRLERAK-----ELAEEKGVSPTQIALAYVLNQPFPTVPiiGPRT 279

                         170
                  ....*....|..
gi 2796469736 122 MVHLKENISILD 133
Cdd:cd19082   280 PEQLRDSLAAAD 291
AKR_AKR9C1 cd19081
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ...
 10-145 1.59e-05

AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).


Pssm-ID: 381307 [Multi-domain]  Cd Length: 308  Bit Score: 44.13  E-value: 1.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  10 KEGRIRAIGVSNF----------------------LQPHIEALSEIS---DVVPAVNQIEI-----SPLnAQIELT-KYC 58
Cdd:cd19081   142 RQGKVRYIGASNYsawrlqealelsrqhglpryvsLQPEYNLVDRESfegELLPLCREEGIgvipySPL-AGGFLTgKYR 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736  59 QDRGIA-VEAMSTFSHFRSVEPRLEIIEhpLILAIAKKHGKSTVQIVLRWLVQRGII--VIPKTWNMVHLKENISILDFE 135
Cdd:cd19081   221 SEADLPgSTRRGEAAKRYLNERGLRILD--ALDEVAAEHGATPAQVALAWLLARPGVtaPIAGARTVEQLEDLLAAAGLR 298

                         170
                  ....*....|
gi 2796469736 136 LSVDEMAEIT 145
Cdd:cd19081   299 LTDEEVARLD 308
AKR_unchar cd19097
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 1-133 1.78e-05

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381323 [Multi-domain]  Cd Length: 267  Bit Score: 44.06  E-value: 1.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796469736   1 MWEVLEKFYKEGRIRAIGVSNFLQPHIEALSEIS--DVVpavnQIEISPLNAQIELTKYC---QDRGIAVEAMSTF---- 71
Cdd:cd19097   120 LVEALLELKKEGLIRKIGVSVYSPEELEKALESFkiDII----QLPFNILDQRFLKSGLLaklKKKGIEIHARSVFlqgl 195

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2796469736  72 ---------SHFRSVEPRLEIIEhplilAIAKKHGKSTVQIVLRWLVQRGII--VIPKTWNMVHLKENISILD 133
Cdd:cd19097   196 llmepdklpAKFAPAKPLLKKLH-----ELAKKLGLSPLELALGFVLSLPEIdkIVVGVDSLEQLKEIIAAFK 263
AKR_unchar cd19100
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 2-72 5.22e-05

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381326 [Multi-domain]  Cd Length: 238  Bit Score: 42.47  E-value: 5.22e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2796469736   2 WEVLEKFYKEGRIRAIGVSN-FLQPHIEAL-SEISDVV-PAVNQIEISPLNAQIELTKYCQDRGIAVEAMSTFS 72
Cdd:cd19100   122 LEALLEAKEEGKIRFIGISGhSPEVLLRALeTGEFDVVlFPINPAGDHIDSFREELLPLAREKGVGVIAMKVLA 195
AKR_AKR9A1-2 cd19146
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ...
 73-146 8.42e-03

Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.


Pssm-ID: 381372 [Multi-domain]  Cd Length: 326  Bit Score: 36.25  E-value: 8.42e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2796469736  73 HFRSVEPRLEIIehplilaiAKKHGKSTVQIVLRWLVQRGIIVIP-----KTwnmVHLKENISILDFELSVDEMAEITS 146
Cdd:cd19146   246 KERKVSEKLEKV--------AEEKGTAITSVALAYVMHKAPYVFPivggrKV---EHLKGNIEALGISLSDEEIQEIED 313
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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