|
Name |
Accession |
Description |
Interval |
E-value |
| RNR_1b_NrdE |
TIGR04170 |
ribonucleoside-diphosphate reductase, class 1b, alpha subunit; Members of this family are NrdE, ... |
6-705 |
0e+00 |
|
ribonucleoside-diphosphate reductase, class 1b, alpha subunit; Members of this family are NrdE, the alpha subunit of class 1b ribonucleotide reductase. This form uses a dimanganese moiety associated with a tyrosine radical to reduce the cellular requirement for iron.
Pssm-ID: 211905 [Multi-domain] Cd Length: 698 Bit Score: 1366.76 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 6 DYHALNAMLNLYDKAGHIQFDKDQQAIDAFFAAHVRPHSVTFASQHERLETLVREGYYDDAVLARYDRAFVLRLFEHAHA 85
Cdd:TIGR04170 1 DYHALNNELNLYDDNGKIQFDKDKEALDAYFLEHVNQNTVFFHNLKEKLDYLVENNYYEEEVLDKYSFEFVIELFEHAYA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 86 SGFRFQTFLGAWKFYTSYTLKTFDGKRYLEHFEDRVTMVALTLAQGDETLATQLTDEMLSGRFQPATPTFLNCGKQQRGE 165
Cdd:TIGR04170 81 SKFRFPSFMGAFKFYTSYALKTNDGKRYLERYEDRVCMVALTLANGDEELAKQLVDEMISQRYQPATPTFLNAGRARRGE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 166 LVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGA 245
Cdd:TIGR04170 161 LVSCFLLRVEDNMNSIGRAINSALQLSKRGGGVALNLSNLREAGAPIKGIENQSSGVIPVMKLLEDAFSYANQLGQRQGA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 246 GAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFRLAKENAQMALFSPYDVQRRYGKPFGDIAISERYDEL 325
Cdd:TIGR04170 241 GAVYLNAFHPDILRFLDTKKENADEKIRIKTLSLGVVIPDKFFELAKENKDMYLFSPYDVEREYGVPFDDIDITEKYDEM 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 326 IADPHVRKTYINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIAGRINMSNLCSEILQVNSASRYDDNLDYTHIGHDIS 405
Cdd:TIGR04170 321 VANPRIRKKKINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIIGRIKMSNLCSEILQVSEASLYNDYLEYDEIGHDIS 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 406 CNLGSLNIAHVMDSPDIGRTVETAIRGLTAVSDMSHIRSVPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFT 485
Cdd:TIGR04170 401 CNLGSLNIANVMDSPDFGRTVETAIRALTAVSDMSHIRNVPSIRKGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFT 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 486 NLYFYTITWHAVHTSMRLARERGKTFAGFAQSRYASGDYFTQYLQDDWQPKTAKVRALFarSGIMLPTREMWLKLRDDVM 565
Cdd:TIGR04170 481 NIYFMTVNYYSLRRSMEIARERGETFAGFEQSDYASGEYFDKYVSQEFAPKTEKVRELF--EGIHIPTREDWAELKDDVM 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 566 RYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIEIRKEGKTGRVYYPAPFMTNENLDMYQDAYDIGPEKIIDTYAEAT 645
Cdd:TIGR04170 559 EYGLYHQNRLAVAPTGSISYINHSTSSIHPIVSKIEIRKEGKIGRVYYPAPFLTNENLEYYQDAYDIDMEKIIDTYATAT 638
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 646 RHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIKSLYYIRLRQLALEGTEIEGCVSCAL 705
Cdd:TIGR04170 639 QHVDQGLSLTLFFKDTATTRDLNRAQIYAWHKGIKTLYYIRLRQLALEGTEIEGCVSCAL 698
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
58-696 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 753.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 58 VREGYYDDAVLarydRAFVLRLFEHAHASGFRFQTFLGAWKFYTSYTLKTFDGKrYLEHFEDRVTMVALTLAQGD----- 132
Cdd:COG0209 20 VEEGLYDERLL----EEDLEELAAAIDPERDRFFSYNALKTLYDRYLLKDEDGK-PLETPQDLFMRVAMGLAAAEkpedr 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 133 ETLATQLTDEMLSGRFQPATPTFLNCGKQqRGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPI 212
Cdd:COG0209 95 EEWAKEFYDLLSSLRFLPATPTLFNAGTP-RGQLSSCFVLPVEDSLESIFDALKDAALLSKSGGGVGFNFSRLRPKGSPI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 213 KRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFRLAK 292
Cdd:COG0209 174 KGTGGVSSGPVPFMKVFDDAAVAVNQGGKRRGANMVYLRVWHPDIEEFLDLKKNNGDERRRLHNFNISVWIPDLFMEAVE 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 293 ENAQMALFSPYDVQRRYGKPFGDiaISERYDELIADPHVRKTyINARDFFQTLAEIQFESGYPYIMFEDTVNRANPI--A 370
Cdd:COG0209 254 EDEDWTLFSPREVPDLYGLYGEE--FEEAYEEYEADGRVYKT-IKARELWRKILESAWETGEPGILFKDTINRRNPLphL 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 371 GRINMSNLCSEILQVNSASryddnldythigHDISCNLGSLNIAHVM-----DSPDIGRTVETAIRGLTAVSDMSHIrSV 445
Cdd:COG0209 331 GVIHSSNLCGEIPLLPYES------------EDASCNLGSINLAKFVkdgefDWEKLEETVRTAVRFLDNVIDINDY-PV 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 446 PSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGkTFAGFAQSRYASGDYF 525
Cdd:COG0209 398 PEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKERG-AFPAFEGSKYAKGILP 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 526 TQYLQDDWQPktakvralfarsgimlPTREMWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIEIRKE 605
Cdd:COG0209 477 FDKYLDDLLI----------------PTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSLVYVRKV 540
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 606 GKTGRVYYPAPFM------------------------------TNENLDMYQDAYDIGPEKIIDTYAEATRHVDQGLSLT 655
Cdd:COG0209 541 LDGGEFTVVNPYLvralkelglwdeelvekikedgsvqdidelPEELKELYVTAYEIDPEWHIDMQAARQKHVDQAISKT 620
|
650 660 670 680
....*....|....*....|....*....|....*....|.
gi 2791323855 656 LFFPDTATTRDINKAQIYAWRKGIKSLYYIRLRQLALEGTE 696
Cdd:COG0209 621 LNLPNDATVEDLAELYLLAWKLGLKGIYYYRDGSRTGQVLS 661
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
117-686 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 618.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 117 FEDRVTMVALTLAQGDETLATQLTDEMLSGRFQPATPTFLNCGKQqRGELVSCFLLRIEDNMESIGRAVNSALQLSKRGG 196
Cdd:cd01679 1 PQDRLMRVALGLASGDLEWAKEFYDLLSKQRFTPATPTLFNAGTP-RGQLSSCFLLTVDDSLESIYDTIKECAQLSKIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 197 GVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKT 276
Cdd:cd01679 80 GIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGGQRKGAGAVYLEIWHPDIEEFLDLKKNNGDERRRARD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 277 LSLGVVIPDITFRLAKenaqmalfspydvqrrygkpfgdiaiserydeliadphvrktyinaRDFFQTLAEIQFESGYPY 356
Cdd:cd01679 160 LFYGVWIPDLFMERVE----------------------------------------------RDLWRKILESQFETGYPY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 357 IMFEDTVNRANP--IAGRINMSNLCSEILQVNSASRyddnldyTHIGHDISCNLGSLNIAHVMDSPDIGRTVETAIRGLT 434
Cdd:cd01679 194 ILFKDTCNRKNPqkHLGTIKSSNLCTEILQPTSPSE-------DEPGEDAVCNLASINLGNFVTFEKLEEVVKLAVRALD 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 435 AVSDMSHIrSVPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGktfagf 514
Cdd:cd01679 267 NVIDLNYY-PVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG------ 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 515 aqsryasgdyftqylqddwqpktakvralfarsgimlptremwlklrddvmryGIYNQNLQAVPPTGSISYINHATSSIH 594
Cdd:cd01679 340 -----------------------------------------------------GLRNSLLLAIAPTASISQILGATPSIE 366
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 595 PIVAKIEIRKEGKtGRVYYPAPFMTNEN--LDMYQDAYDIGPEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQI 672
Cdd:cd01679 367 PITSNIYVRRVLS-GEFPVVNPHLEKDLweYGLYKTAYEIDQRWLIDLAADRQKHIDQGQSLNLFLTPPATTRDLNSLYF 445
|
570
....*....|....
gi 2791323855 673 YAWRKGIKSLYYIR 686
Cdd:cd01679 446 YAWKKGLKTLYYLR 459
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
167-685 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 590.33 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 167 VSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAG 246
Cdd:pfam02867 1 SSCFLLSVEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGGKRRGAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 247 AVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFRLAKENAQMALFSPY---DVQRRYGKPFgdiaiSERYD 323
Cdd:pfam02867 81 AVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPReapDLEDLYGEEF-----EKEYY 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 324 ELIADPHVRKTYINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIA--GRINMSNLCSEILQVNSASRYddnldythig 401
Cdd:pfam02867 156 EREENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKhlGTIKSSNLCTEIVQPTSPSEI---------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 402 hdISCNLGSLNIAHVMDSP------DIGRTVETAIRGLTAVSDMShIRSVPSIAAGNAASHAIGLGQMNLHGYLAREGIA 475
Cdd:pfam02867 226 --AVCNLASINLAKFVEFGgtfdfeKLREVVKLAVRALDNVIDIN-DYPVPEARRSNKRHRPIGLGVMGLADALAKLGIP 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 476 YGSPEALDFTNLYFYTITWHAVHTSMRLARERGkTFAGFAQSRYASG-DYFTQYLQDDWQPKTAKvralfarsgimlpTR 554
Cdd:pfam02867 303 YDSEEARDLNDKIFETMYYYALKASSELAKEKG-PFPGFEGSKYSKGiLQFDKYVKTDFAPKASK-------------TR 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 555 EMWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIEIRKEGKtgrvyypapfmtNENLDMYQDAYDIGP 634
Cdd:pfam02867 369 EDWEELREDIKKYGLRNSQLTAIAPTGSISQIAGATESIEPIFSNVYSRKVLS------------EETKEYYKTAYDIDQ 436
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 2791323855 635 EKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIKSLYYI 685
Cdd:pfam02867 437 KAHIDMAAARQPFVDQSISKTLFLPNDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| PRK09209 |
PRK09209 |
ribonucleoside-diphosphate reductase subunit alpha; |
44-704 |
6.59e-110 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181700 [Multi-domain] Cd Length: 761 Bit Score: 350.18 E-value: 6.59e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 44 SVTFASQHERLETLVREGYYDDAVLARYDRAFVLRLFEHAHASGFRFQTFLGAWKFYTSYTLKTFDGKRYlEHFEDRVTM 123
Cdd:PRK09209 109 SEKYGSFVGLQESLAERGIYSNDLLKRYSKEELIEAGKMIDPERDKLFTYIGLYLLADRYLATDSDRNVY-ELPQERWLT 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 124 VALTLAQGD-ETLATQLTDE---MLSGRFQP-ATPTFLNCGKQQrGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGV 198
Cdd:PRK09209 188 IALYLMQNEpRERRMQLVKEaywALSNLYMTvATPTLANAGKVG-GQLSSCFIDTVDDSLQGIYDSNTDVARVSKHGGGV 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 199 AFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLS 278
Cdd:PRK09209 267 GAYLGKVRSRGSDIRGFKGVSSGVIPWIKQLNNTAVSVDQLGQRKGAIAVYLDVWHKDIESFLDLRLNNGDERLRAHDVF 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 279 LGVVIPDITFRLAKENAQMALFSPYDVQRR--------YGKPFGDIAISERYDELIADPHVRKTYINARDFFQTLAEIQF 350
Cdd:PRK09209 347 TGVCIPDLFMEAVERRGDWYLFDPHEVKKVmgwyledfYDEKKGDGSFREKYEECVADERLSRKTVKAIDIMKRIMVSQL 426
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 351 ESGYPYIMFEDTVNRANP--IAGRINMSNLCSEILQVNSASRY------DDNLDYTHIGHD-ISCNLGSLNIAHVMDSPD 421
Cdd:PRK09209 427 ETGNPFMFYRDEVNRMNPnkHEGMIYSSNLCTEIMQNMSPTVMiqeiisGGQIVITKQPGDfVVCNLSSINLGRAVTADV 506
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 422 IGRTVETAIRGLTAVSDMSHIrSVPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSM 501
Cdd:PRK09209 507 LERLIPIQVRMLDNVIDLNQL-PVPQATITNQKYRAIGLGTFGWHHLLALKGIAWESEEAVQYADELYERINYLTIQASM 585
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 502 RLARERGkTFAGFAQSRYASGDYftqylqddwqpktakvralFARSGImlpTREMWLKLRDDVMRYGIYNQNLQAVPPTG 581
Cdd:PRK09209 586 ELAKEKG-AYPVFKGSDWQTGEY-------------------FERRGY---NSPQWDELAAQVAENGVRNAYLMAVAPNM 642
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 582 SISYINHATSSIHPIVAKIEIrKEGKTGRVYYPAPFMTNENLDMYQD-AYDIGPEKIIDTYAEATRHVDQGLSLTLFFPD 660
Cdd:PRK09209 643 STAQIAGSTASIDPIYSAFYY-EEKKDYRRPVTAPDLSLDTWPYYEKgAYKVDQFWSIRQNAARQRHVDQSISFNFYVPS 721
|
650 660 670 680
....*....|....*....|....*....|....*....|....
gi 2791323855 661 TATTRDINKAQIYAWRKGIKSLYYIRLRQLalegtEIEGCVSCA 704
Cdd:PRK09209 722 TIRASELLDLHMTAWKEGLKTTYYVRSTDI-----DIEECEWCS 760
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RNR_1b_NrdE |
TIGR04170 |
ribonucleoside-diphosphate reductase, class 1b, alpha subunit; Members of this family are NrdE, ... |
6-705 |
0e+00 |
|
ribonucleoside-diphosphate reductase, class 1b, alpha subunit; Members of this family are NrdE, the alpha subunit of class 1b ribonucleotide reductase. This form uses a dimanganese moiety associated with a tyrosine radical to reduce the cellular requirement for iron.
Pssm-ID: 211905 [Multi-domain] Cd Length: 698 Bit Score: 1366.76 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 6 DYHALNAMLNLYDKAGHIQFDKDQQAIDAFFAAHVRPHSVTFASQHERLETLVREGYYDDAVLARYDRAFVLRLFEHAHA 85
Cdd:TIGR04170 1 DYHALNNELNLYDDNGKIQFDKDKEALDAYFLEHVNQNTVFFHNLKEKLDYLVENNYYEEEVLDKYSFEFVIELFEHAYA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 86 SGFRFQTFLGAWKFYTSYTLKTFDGKRYLEHFEDRVTMVALTLAQGDETLATQLTDEMLSGRFQPATPTFLNCGKQQRGE 165
Cdd:TIGR04170 81 SKFRFPSFMGAFKFYTSYALKTNDGKRYLERYEDRVCMVALTLANGDEELAKQLVDEMISQRYQPATPTFLNAGRARRGE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 166 LVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGA 245
Cdd:TIGR04170 161 LVSCFLLRVEDNMNSIGRAINSALQLSKRGGGVALNLSNLREAGAPIKGIENQSSGVIPVMKLLEDAFSYANQLGQRQGA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 246 GAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFRLAKENAQMALFSPYDVQRRYGKPFGDIAISERYDEL 325
Cdd:TIGR04170 241 GAVYLNAFHPDILRFLDTKKENADEKIRIKTLSLGVVIPDKFFELAKENKDMYLFSPYDVEREYGVPFDDIDITEKYDEM 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 326 IADPHVRKTYINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIAGRINMSNLCSEILQVNSASRYDDNLDYTHIGHDIS 405
Cdd:TIGR04170 321 VANPRIRKKKINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIIGRIKMSNLCSEILQVSEASLYNDYLEYDEIGHDIS 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 406 CNLGSLNIAHVMDSPDIGRTVETAIRGLTAVSDMSHIRSVPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFT 485
Cdd:TIGR04170 401 CNLGSLNIANVMDSPDFGRTVETAIRALTAVSDMSHIRNVPSIRKGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFT 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 486 NLYFYTITWHAVHTSMRLARERGKTFAGFAQSRYASGDYFTQYLQDDWQPKTAKVRALFarSGIMLPTREMWLKLRDDVM 565
Cdd:TIGR04170 481 NIYFMTVNYYSLRRSMEIARERGETFAGFEQSDYASGEYFDKYVSQEFAPKTEKVRELF--EGIHIPTREDWAELKDDVM 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 566 RYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIEIRKEGKTGRVYYPAPFMTNENLDMYQDAYDIGPEKIIDTYAEAT 645
Cdd:TIGR04170 559 EYGLYHQNRLAVAPTGSISYINHSTSSIHPIVSKIEIRKEGKIGRVYYPAPFLTNENLEYYQDAYDIDMEKIIDTYATAT 638
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 646 RHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIKSLYYIRLRQLALEGTEIEGCVSCAL 705
Cdd:TIGR04170 639 QHVDQGLSLTLFFKDTATTRDLNRAQIYAWHKGIKTLYYIRLRQLALEGTEIEGCVSCAL 698
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
58-696 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 753.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 58 VREGYYDDAVLarydRAFVLRLFEHAHASGFRFQTFLGAWKFYTSYTLKTFDGKrYLEHFEDRVTMVALTLAQGD----- 132
Cdd:COG0209 20 VEEGLYDERLL----EEDLEELAAAIDPERDRFFSYNALKTLYDRYLLKDEDGK-PLETPQDLFMRVAMGLAAAEkpedr 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 133 ETLATQLTDEMLSGRFQPATPTFLNCGKQqRGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPI 212
Cdd:COG0209 95 EEWAKEFYDLLSSLRFLPATPTLFNAGTP-RGQLSSCFVLPVEDSLESIFDALKDAALLSKSGGGVGFNFSRLRPKGSPI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 213 KRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFRLAK 292
Cdd:COG0209 174 KGTGGVSSGPVPFMKVFDDAAVAVNQGGKRRGANMVYLRVWHPDIEEFLDLKKNNGDERRRLHNFNISVWIPDLFMEAVE 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 293 ENAQMALFSPYDVQRRYGKPFGDiaISERYDELIADPHVRKTyINARDFFQTLAEIQFESGYPYIMFEDTVNRANPI--A 370
Cdd:COG0209 254 EDEDWTLFSPREVPDLYGLYGEE--FEEAYEEYEADGRVYKT-IKARELWRKILESAWETGEPGILFKDTINRRNPLphL 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 371 GRINMSNLCSEILQVNSASryddnldythigHDISCNLGSLNIAHVM-----DSPDIGRTVETAIRGLTAVSDMSHIrSV 445
Cdd:COG0209 331 GVIHSSNLCGEIPLLPYES------------EDASCNLGSINLAKFVkdgefDWEKLEETVRTAVRFLDNVIDINDY-PV 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 446 PSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGkTFAGFAQSRYASGDYF 525
Cdd:COG0209 398 PEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKERG-AFPAFEGSKYAKGILP 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 526 TQYLQDDWQPktakvralfarsgimlPTREMWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIEIRKE 605
Cdd:COG0209 477 FDKYLDDLLI----------------PTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSLVYVRKV 540
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 606 GKTGRVYYPAPFM------------------------------TNENLDMYQDAYDIGPEKIIDTYAEATRHVDQGLSLT 655
Cdd:COG0209 541 LDGGEFTVVNPYLvralkelglwdeelvekikedgsvqdidelPEELKELYVTAYEIDPEWHIDMQAARQKHVDQAISKT 620
|
650 660 670 680
....*....|....*....|....*....|....*....|.
gi 2791323855 656 LFFPDTATTRDINKAQIYAWRKGIKSLYYIRLRQLALEGTE 696
Cdd:COG0209 621 LNLPNDATVEDLAELYLLAWKLGLKGIYYYRDGSRTGQVLS 661
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
117-686 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 618.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 117 FEDRVTMVALTLAQGDETLATQLTDEMLSGRFQPATPTFLNCGKQqRGELVSCFLLRIEDNMESIGRAVNSALQLSKRGG 196
Cdd:cd01679 1 PQDRLMRVALGLASGDLEWAKEFYDLLSKQRFTPATPTLFNAGTP-RGQLSSCFLLTVDDSLESIYDTIKECAQLSKIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 197 GVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKT 276
Cdd:cd01679 80 GIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGGQRKGAGAVYLEIWHPDIEEFLDLKKNNGDERRRARD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 277 LSLGVVIPDITFRLAKenaqmalfspydvqrrygkpfgdiaiserydeliadphvrktyinaRDFFQTLAEIQFESGYPY 356
Cdd:cd01679 160 LFYGVWIPDLFMERVE----------------------------------------------RDLWRKILESQFETGYPY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 357 IMFEDTVNRANP--IAGRINMSNLCSEILQVNSASRyddnldyTHIGHDISCNLGSLNIAHVMDSPDIGRTVETAIRGLT 434
Cdd:cd01679 194 ILFKDTCNRKNPqkHLGTIKSSNLCTEILQPTSPSE-------DEPGEDAVCNLASINLGNFVTFEKLEEVVKLAVRALD 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 435 AVSDMSHIrSVPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGktfagf 514
Cdd:cd01679 267 NVIDLNYY-PVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG------ 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 515 aqsryasgdyftqylqddwqpktakvralfarsgimlptremwlklrddvmryGIYNQNLQAVPPTGSISYINHATSSIH 594
Cdd:cd01679 340 -----------------------------------------------------GLRNSLLLAIAPTASISQILGATPSIE 366
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 595 PIVAKIEIRKEGKtGRVYYPAPFMTNEN--LDMYQDAYDIGPEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQI 672
Cdd:cd01679 367 PITSNIYVRRVLS-GEFPVVNPHLEKDLweYGLYKTAYEIDQRWLIDLAADRQKHIDQGQSLNLFLTPPATTRDLNSLYF 445
|
570
....*....|....
gi 2791323855 673 YAWRKGIKSLYYIR 686
Cdd:cd01679 446 YAWKKGLKTLYYLR 459
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
167-685 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 590.33 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 167 VSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAG 246
Cdd:pfam02867 1 SSCFLLSVEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGGKRRGAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 247 AVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFRLAKENAQMALFSPY---DVQRRYGKPFgdiaiSERYD 323
Cdd:pfam02867 81 AVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPReapDLEDLYGEEF-----EKEYY 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 324 ELIADPHVRKTYINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIA--GRINMSNLCSEILQVNSASRYddnldythig 401
Cdd:pfam02867 156 EREENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKhlGTIKSSNLCTEIVQPTSPSEI---------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 402 hdISCNLGSLNIAHVMDSP------DIGRTVETAIRGLTAVSDMShIRSVPSIAAGNAASHAIGLGQMNLHGYLAREGIA 475
Cdd:pfam02867 226 --AVCNLASINLAKFVEFGgtfdfeKLREVVKLAVRALDNVIDIN-DYPVPEARRSNKRHRPIGLGVMGLADALAKLGIP 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 476 YGSPEALDFTNLYFYTITWHAVHTSMRLARERGkTFAGFAQSRYASG-DYFTQYLQDDWQPKTAKvralfarsgimlpTR 554
Cdd:pfam02867 303 YDSEEARDLNDKIFETMYYYALKASSELAKEKG-PFPGFEGSKYSKGiLQFDKYVKTDFAPKASK-------------TR 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 555 EMWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIEIRKEGKtgrvyypapfmtNENLDMYQDAYDIGP 634
Cdd:pfam02867 369 EDWEELREDIKKYGLRNSQLTAIAPTGSISQIAGATESIEPIFSNVYSRKVLS------------EETKEYYKTAYDIDQ 436
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 2791323855 635 EKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIKSLYYI 685
Cdd:pfam02867 437 KAHIDMAAARQPFVDQSISKTLFLPNDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
93-688 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 550.83 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 93 FLGAWKFYTSYTLKTFDGKR---YLEHFEDRVTMVALTLAQGDETLA-TQLTDEMLSG-RFQPATPTFLNCGKQqRGELV 167
Cdd:TIGR02506 1 YMGLKELYNRYLLRNAATGAiyeSPQEAYMRVAMGLASLEPKDTRLAdAIRFYDLLSRlKISPATPTLFNAGTP-RGQLS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 168 SCFLLRI-EDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAG 246
Cdd:TIGR02506 80 SCFLLDVtDDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGGKRPGAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 247 AVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFRLAKENAQMALFSPYDVQRRYGKPFgdIAISERYDELI 326
Cdd:TIGR02506 160 AVYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYG--EEFEEEYERLE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 327 ADPHVRKTY--INARDFFQTLAEIQFESGYPYIMFEDTVNRANPIA---GRINMSNLCSEILQVNSASryddnldytHIG 401
Cdd:TIGR02506 238 KDVEARKKIrkVSARDLMKDILRTRVETGRPYILFKDAVNKHNPFKtggGAIKMSNLCTEITQPTDDS---------HKG 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 402 HDISCNLGSLNIA-HVMDS----PDIGRTVETAIRGLTAVSDMSHIRSVPSiAAGNAASHAIGLGQMNLHGYLAREGIAY 476
Cdd:TIGR02506 309 ETAVCNLASVNLAnFVMEDkfdfSELEDAVRIAVRFLDNVIDLQNYPTAPA-AKSNQRRRSIGIGVMGLHDVLAKLGLPY 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 477 GSPEALDFTNLYFYTITWHAVHTSMRLARERGkTFAGFAQSRYASGDYFTQYLQDDWQPKTakvralfarsgIMLPTREM 556
Cdd:TIGR02506 388 DSEEARDLNDRIFEAIYYYAIKASAELAKEKG-PFPGFSGSKYAKGWLHPDTWEKTIDPKT-----------SMAPTEED 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 557 WLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIEIRKEGK----------------------------T 608
Cdd:TIGR02506 456 WEALRERIKEYGLRNSQLTALMPTASSSQLTGVTESIEPVFSNIFTKKTLSgeflipnkylmkeleelglwdadrrgdiV 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 609 GRVYYPAPFMT--NENLDMYQDAYDIGPEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIKSLYYIR 686
Cdd:TIGR02506 536 ENVGSPQPIAAipETLKYKYKTAYELDQEALIDMAADRQKFVDQSISLNLFLTEEVTAKDLLKLLLLAWKKGLKTMYYCR 615
|
..
gi 2791323855 687 LR 688
Cdd:TIGR02506 616 SR 617
|
|
| PRK09209 |
PRK09209 |
ribonucleoside-diphosphate reductase subunit alpha; |
44-704 |
6.59e-110 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181700 [Multi-domain] Cd Length: 761 Bit Score: 350.18 E-value: 6.59e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 44 SVTFASQHERLETLVREGYYDDAVLARYDRAFVLRLFEHAHASGFRFQTFLGAWKFYTSYTLKTFDGKRYlEHFEDRVTM 123
Cdd:PRK09209 109 SEKYGSFVGLQESLAERGIYSNDLLKRYSKEELIEAGKMIDPERDKLFTYIGLYLLADRYLATDSDRNVY-ELPQERWLT 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 124 VALTLAQGD-ETLATQLTDE---MLSGRFQP-ATPTFLNCGKQQrGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGV 198
Cdd:PRK09209 188 IALYLMQNEpRERRMQLVKEaywALSNLYMTvATPTLANAGKVG-GQLSSCFIDTVDDSLQGIYDSNTDVARVSKHGGGV 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 199 AFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLS 278
Cdd:PRK09209 267 GAYLGKVRSRGSDIRGFKGVSSGVIPWIKQLNNTAVSVDQLGQRKGAIAVYLDVWHKDIESFLDLRLNNGDERLRAHDVF 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 279 LGVVIPDITFRLAKENAQMALFSPYDVQRR--------YGKPFGDIAISERYDELIADPHVRKTYINARDFFQTLAEIQF 350
Cdd:PRK09209 347 TGVCIPDLFMEAVERRGDWYLFDPHEVKKVmgwyledfYDEKKGDGSFREKYEECVADERLSRKTVKAIDIMKRIMVSQL 426
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 351 ESGYPYIMFEDTVNRANP--IAGRINMSNLCSEILQVNSASRY------DDNLDYTHIGHD-ISCNLGSLNIAHVMDSPD 421
Cdd:PRK09209 427 ETGNPFMFYRDEVNRMNPnkHEGMIYSSNLCTEIMQNMSPTVMiqeiisGGQIVITKQPGDfVVCNLSSINLGRAVTADV 506
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 422 IGRTVETAIRGLTAVSDMSHIrSVPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSM 501
Cdd:PRK09209 507 LERLIPIQVRMLDNVIDLNQL-PVPQATITNQKYRAIGLGTFGWHHLLALKGIAWESEEAVQYADELYERINYLTIQASM 585
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 502 RLARERGkTFAGFAQSRYASGDYftqylqddwqpktakvralFARSGImlpTREMWLKLRDDVMRYGIYNQNLQAVPPTG 581
Cdd:PRK09209 586 ELAKEKG-AYPVFKGSDWQTGEY-------------------FERRGY---NSPQWDELAAQVAENGVRNAYLMAVAPNM 642
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 582 SISYINHATSSIHPIVAKIEIrKEGKTGRVYYPAPFMTNENLDMYQD-AYDIGPEKIIDTYAEATRHVDQGLSLTLFFPD 660
Cdd:PRK09209 643 STAQIAGSTASIDPIYSAFYY-EEKKDYRRPVTAPDLSLDTWPYYEKgAYKVDQFWSIRQNAARQRHVDQSISFNFYVPS 721
|
650 660 670 680
....*....|....*....|....*....|....*....|....
gi 2791323855 661 TATTRDINKAQIYAWRKGIKSLYYIRLRQLalegtEIEGCVSCA 704
Cdd:PRK09209 722 TIRASELLDLHMTAWKEGLKTTYYVRSTDI-----DIEECEWCS 760
|
|
| PRK07088 |
PRK07088 |
ribonucleoside-diphosphate reductase subunit alpha; |
54-704 |
1.24e-95 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180831 [Multi-domain] Cd Length: 764 Bit Score: 312.51 E-value: 1.24e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 54 LETLVREGYYDDAVLARYDRAFVLRLFEHAHASGFRFQTFLGAWKFYTSYTLKTFDGKrYLEHFEDRVTMVALTLA--QG 131
Cdd:PRK07088 121 VKKLVEEKLYGEYLLQNYSKEEIKELEKYIKPERDFLFNYEGLKLLADRYLVKGFNRE-ILELPQERFMGIAMHLAipEG 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 132 DET---LATQLTDEMLSGRFQPATPTFLNCGKQQRgELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREA 208
Cdd:PRK07088 200 KEKrvyYAKKFYDLLSELKATVATPTLSNAGTPFY-QLSSCFISVVDDNLWSIYDVNQKFAQVSKHGGALGIYTGKIRAL 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 209 GAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITF 288
Cdd:PRK07088 279 NSEIRGFKNASGGVIPWIKLYNDTAIAVDQLGKRKGGAAITLDIWHKDIPEFLDLKTNNGDDRRKAHDIFPGVSYPDLFM 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 289 RLAKENAQMALFSPYDVQRRYGKP----FGDIAISE---RYDELIADPHVRKTYINARDFFQTLAEIQFESGYPYIMFED 361
Cdd:PRK07088 359 KRLEKRENWSLFDPHEIKKVKGYSledyYDEEDRKEftkKYLECEEDTNIPRRTVPVLDIMKKIMKSAVETGTPFIFFRD 438
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 362 TVNRANPI--AGRINMSNLCSEILQVNSASRY------DDNLDYTHI-----GHDISCNLGSLNIAHVmDSPDIGRTVET 428
Cdd:PRK07088 439 TVNKANPNkhKGMIYSSNLCHEIAQNMSESELleeeiiDENGYYEVVqkikaGDMVTCNLNSIVLGNV-DDEELEEVIPT 517
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 429 AIRGLTAVSDMSHIrSVPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERG 508
Cdd:PRK07088 518 QIRMLDNVISLNYY-PVPEAEITSDKYRAIGLGTSGYHHMLANNKIRWESDEHIKFADKIYEEIAYYAIKASMELAKEKG 596
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 509 KtFAGFAQSRYASGDYFTqylqddwqpktakvralfaRSGImlpTREMWLKLRDDVMRYGIYNQNLQAVPPTGSISYINH 588
Cdd:PRK07088 597 S-YPAFKGSEWETGKYFE-------------------RRGY---NSERWKKLKEEIKKYGMRNGYITAVAPTGSTSNIAN 653
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 589 ATSSIHPIVAK--IEIRKEGKTGRVyypAPFMTNENLDMYQDAYDIGPEKIIDTYAEATRHVDQGLSLTLFFPDTATTRD 666
Cdd:PRK07088 654 TTAGIDPVFKRffMEEKKGSFTPKT---APDLNEENFWYYKEAHTIDQQWSIKACGVRQRHIDQAQSFNLYITPEYKAKQ 730
|
650 660 670
....*....|....*....|....*....|....*...
gi 2791323855 667 INKAQIYAWRKGIKSLYYIRLRQLalegtEIEGCVSCA 704
Cdd:PRK07088 731 ILNLYIEAWKQGVKTIYYVRNKSL-----EMDECTSCS 763
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
51-704 |
1.08e-89 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 298.59 E-value: 1.08e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 51 HERLETLVREGYYDDAVLARYDRAfvlrlfEHAHASGF------RFQTFLGAWKFYTSYTLKTFDGkRYLEHFEDRVTMV 124
Cdd:PRK12364 196 YDKIKYLTEEGLYGSYILEHYSRE------EIEEAAGFidperdKLFTYSGLDLLLKRYVIRTHSH-EPLESPQEMFLGI 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 125 ALTLA--QGDETL--ATQLTDeMLSG-RFQPATPTFLNCGKQQRgELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVA 199
Cdd:PRK12364 269 ALHLAmpEKQDRMgwVKRFYD-MLSKlKVTMATPTLSNARKPFH-QLSSCFIDTVPDSLDGIYRSIDNFAQVSKFGGGMG 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 200 FLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSL 279
Cdd:PRK12364 347 LYFGKVRAVGSNIRGFQGVAGGVIRWIKLANDTAVAVDQLGMRQGAVAVYLDVWHKDIPEFLQLRTNNGDDRMKAHDVFP 426
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 280 GVVIPDITFRLAKE--NAQMALFSPYDVQRRYGKPFGDIAISE---RYDELIADPHVRKTYINARDFFQTLAEIQFESGY 354
Cdd:PRK12364 427 AVCYPDLFWKMVRDdiNQSWYLFCPHEILTVKGYALEDYYGEEwekRYLDCVNDARISKRSIPIKDLVRLILKSAVETGT 506
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 355 PYIMFEDTVNRANPIA--GRINMSNLCSEILQVNSASRY------DDNLD-----YTHIGHDISCNLGSLNIAH--VMDS 419
Cdd:PRK12364 507 PFTFNRDTVNRANPNKhkGMIYCSNLCTEIAQNMSAIETvsteieTEDGDtvvvtTTRPGDFVVCNLASLSLGNidLEDE 586
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 420 PDIGRTVETAIRGLTAVSDMSHIrSVPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHT 499
Cdd:PRK12364 587 EELEEVVRTVVRALDNVIDLNFY-PVPYAQITNKRYRSIGLGVSGYHHALAKNGIRWESEEHLEFADRVFERINYAAIKA 665
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 500 SMRLARERGKtFAGFAQSRYASGDYFTQ--YLQDDWQpktakvralfarsgimlptremwlKLRDDVMRYGIYNQNLQAV 577
Cdd:PRK12364 666 SMEIAKEKGA-YGYFEGSDWQTGAYFRKrgYTSEEWQ------------------------RLAREVAENGMRNAYLLAV 720
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 578 PPTGSISYINHATSSIHPIVAK--IEIRKEGKTGRVyypAPFMTNENLDMYQDAYDIGPEKIIDTYAEATRHVDQGLSLT 655
Cdd:PRK12364 721 APTSSTSIIAGTTAGVDPVMKRyfLEEKKGALMPRV---APELSDKTFWLYKNAHLIDQKWSIRAAGVRQRHIDQAQSVN 797
|
650 660 670 680
....*....|....*....|....*....|....*....|....*....
gi 2791323855 656 LFFPDTATTRDINKAQIYAWRKGIKSLYYIRLRQLalegtEIEGCVSCA 704
Cdd:PRK12364 798 LYITNEFTMRQVLDLYLLAWEEGVKTIYYVRSKSL-----EVEECESCS 841
|
|
| PRK09102 |
PRK09102 |
ribonucleoside-diphosphate reductase subunit alpha; |
106-703 |
8.26e-80 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236378 [Multi-domain] Cd Length: 601 Bit Score: 266.05 E-value: 8.26e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 106 KTFDGKRYL---EHFEDRVTMVALTLAQGDETLATQLTDEMLSGRFQPATPTFLNCGKQqRGELVSCFLLRIEDNMESIG 182
Cdd:PRK09102 26 KATLRDRYLlegESYQDLFARIAEAYADIDPEHAQRFYDYMSRGWFMPATPVLSNGGTD-RGLPISCFLNYVEDSLEGIV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 183 RAVNSALQLSKRGGGVAFLLSNLREAGAPIKRiENQSSGVIP---VMKMLEDAFSyanQLGARQGAGAVYLHAHHPDILR 259
Cdd:PRK09102 105 NTWNENVWLAKRGGGIGSYWGNVRSIGEPIRN-NGKSSGIIPfikVMDSLTLAIS---QGSLRRGSFAVYLDIEHPEIEE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 260 FLDTKRENADEKIRIKTLSLGVVIPDITFRLAKENAQMALFSPYDVQrrygkpfgdiaiserydeliadphVRKTyINAR 339
Cdd:PRK09102 181 FLDIRKPTGDPNRKALNLHHGVCVTDEFMEAVEDGDEWDLISPKDKS------------------------VIRT-VKAR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 340 DFFQTLAEIQFESGYPYIMFEDTVNRANP----IAG-RINMSNLCSEILQVnsaSRYDdnldytHIGHDIS--CNLGSLN 412
Cdd:PRK09102 236 DLWAKILETRIETGEPYLLFIDNVNRALPevykDLGlKVKASNLCSEITLP---TGID------HLGEDRTavCCLSSLN 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 413 IAHVMDSPDIGRTVETAIRGLTAVsdMSH-IRSVPSI--AAGNAASH--AIGLGQMNLHGYLAREGIAYGSPEALDFTNL 487
Cdd:PRK09102 307 LEYYDEWKDTDAFIEDLMRFLDNV--LQDfIDKAPDEmeRAKYSAMRerSVGLGVMGFHSYLQSKMIPFESVMAKQWNKK 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 488 YFYTITWHAVHTSMRLARERGktfagfaqsryasgdyftqylqddwQPKTAKVRALFARsgimlptremwlklrddvmry 567
Cdd:PRK09102 385 IFKHIREQADKASKELAKEKG-------------------------ECPDAAGYGVMRR--------------------- 418
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 568 giyNQNLQAVPPTGSISYINHATS-SIHPIVAKIEIRKeGKTGRVYYPAP------------------------------ 616
Cdd:PRK09102 419 ---FSTKMAIAPTASISIILGNTSpGIEPIAANYYTHK-TLKGSFTVKNKyleklleekgkdtdevwssiltnegsvqhl 494
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 617 -FMTNENLDMYQDAYDIGPEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIKSLYYIR--------- 686
Cdd:PRK09102 495 dFLSEEEKDVFKTAFEIDQRWIIELAADRQKYIDQAQSLNLFLPANVPKRDLNKLHFEAWKKGVKSLYYQRsksvqradk 574
|
650 660
....*....|....*....|....*.
gi 2791323855 687 ---------LRQLALEGTEIEGCVSC 703
Cdd:PRK09102 575 vshdvlkkrLVEKSAFNRDYDECLAC 600
|
|
| RNR_II_dimer |
cd02888 |
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the ... |
139-682 |
1.95e-79 |
|
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class II RNRs are found in bacteria that can live under both aerobic and anaerobic conditions. Many, but not all members of this class are found to be homodimers. Adenosylcobalamin interacts directly with an active site cysteine to form the reactive cysteine radical.
Pssm-ID: 153089 [Multi-domain] Cd Length: 464 Bit Score: 261.02 E-value: 1.95e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 139 LTDEMLSGRFQPATPTFLNCGKQQRGELVSCFLLRIED-NMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIEN 217
Cdd:cd02888 4 FFYLLLSQGFIPNSPTLMNAGTGELGQLSACFVLPVEDdSIEGIFDALKEAALIFKRGGGVGYNFSRLRPKGDIVKSTGG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 218 QSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKiRIKTLSLGVVIPDiTFRLAKENaqm 297
Cdd:cd02888 84 VASGPVSFMRVFDAATGVIKQGGTRRGANMGVLDVDHPDIEEFIDAKMKEEKTV-VLQNFNISVAVTD-AFMEAVEN--- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 298 alfspydvqrryGKPFGDIAISERYdeliaDPHVRKTyINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIA--GRINM 375
Cdd:cd02888 159 ------------DEPWELRNPREPD-----TGKVYRT-VPARELWDKIVEAAWDSADPGVLFIDTINRWNPLPglGRINA 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 376 SNLCSEILQvnsasryddnLDYThighdiSCNLGSLNIA---------HVMDSPDIGRTVETAIRGLTAVSDMSHIrSVP 446
Cdd:cd02888 221 TNPCGEQPL----------LPYE------SCNLGSINLSkfvknpfggASFDFERLREAVRLAVRFLDNVIDVNRY-PLP 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 447 SIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGkTFAGFAQSRYasgdyft 526
Cdd:cd02888 284 EIAEETKATRRIGLGVMGLADMLIKLGIPYDSEEARELAERIMSFIRDAAYRASAELAKERG-PFPLFDASRY------- 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 527 qylqddwqpktakvralfARSGIMLPTREMWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIvakieirkeg 606
Cdd:cd02888 356 ------------------LMLKVIVNAKELPDDVLEEIEKYGIRNAHLTTIAPTGTISLIAGTSSGIEPI---------- 407
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2791323855 607 ktgrvyypapfmtnenldmyqdaydIGPEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIKSL 682
Cdd:cd02888 408 -------------------------FSPEDHVRMQAALQPWVDGAISKTINLPNDATVEDVEAVYLLAWKLGLKGI 458
|
|
| PRK08447 |
PRK08447 |
ribonucleoside-diphosphate reductase subunit alpha; |
92-703 |
2.03e-78 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236266 [Multi-domain] Cd Length: 789 Bit Score: 266.98 E-value: 2.03e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 92 TFLGAWKFYTSYTLKTFDGKRyLEHFEDRVTMVALTLAQGD---ETLATQLTDeMLSgRFQP--ATPTFLNcGKQQRGEL 166
Cdd:PRK08447 138 NYLGIKTLYDRYLIKDRNNNP-IELPQHMFMAIAMFLAQNEldpQKWAKKFYD-VIS-KFEVmlATPTLSN-ARTTRHQL 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 167 VSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAG 246
Cdd:PRK08447 214 SSCYIGSTPDNIEGIFDSYKEMALLSKYGGGIGWDWSKVRAMGSYIDGHKNAAGGIIPFLKITNDIAIAVDQLGTRKGAI 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 247 AVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFRLAKENAQMALFSPYDVQ---RRYGKPFgdiaiSERYD 323
Cdd:PRK08447 294 AVYLEPWHMDISDFIDLRKNSGEERRRAHDLFPALWINDLFMKRVEEDAMWTLFDPYECKdltELYGEEF-----EKRYL 368
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 324 ELIADPHVRKTYINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIA--GRINMSNLCSEILQVN--------------S 387
Cdd:PRK08447 369 EYEKDEKIIKEYINAKELWKKILTNYFETGLPFLCFKDNANRANPNAhaGIIRSSNLCTEIFQNTapnhykikiefedgS 448
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 388 ASRYDDNLD------YTHIGHDIS------------------------CNLGSLNIAHVMDSPDIGRTVETAIRGLTAVS 437
Cdd:PRK08447 449 IEFFEEEELvtvdsgITKKAKKITsldslkgkkiyivekekkdgktavCNLASINLSKINTKEDIERVVPIAIRMLDNVI 528
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 438 DMSH--IRSVpsiAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGKtFAGFA 515
Cdd:PRK08447 529 DLNFypNRKV---KATNLKSRAIGLGVMGEAQMLAEHKIAWGSKEHLEKIDEIMEQISYNAIDASSNLALEKGV-YPDFE 604
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 516 QSRYASGdyftqYLQDDWQPKTAKvrALFARSGIMLPTREmWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHP 595
Cdd:PRK08447 605 GSNWSKG-----IFPIDKANEEAK--KLVERGGLFDSACD-WEGLREKVKKDGMRNGYLMAIAPTSSISILVGTTQTIEP 676
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 596 iVAKIEIRKEGKTGRVYYPAPFMTNENLDMYQDAYDIGPEKIIDTYAEATRHVDQGLSLTLFFP-DTATTRDINKAQIYA 674
Cdd:PRK08447 677 -VYKRKWFEENLSGLIPVVVPNLSPETWQYYTPAYDLDQKDLIKAAAVRQKWIDQGQSLNIFLSlDKASGKYLNEIYTLA 755
|
650 660 670
....*....|....*....|....*....|....
gi 2791323855 675 WRKGIKSLYYIR-----LRQLALEGTEIEgCVSC 703
Cdd:PRK08447 756 WKLGLKSTYYLRsespeSEEVSVADRSIE-CEGC 788
|
|
| NrdJ_Z |
TIGR02504 |
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a ... |
103-680 |
3.50e-75 |
|
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274168 [Multi-domain] Cd Length: 575 Bit Score: 253.01 E-value: 3.50e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 103 YTLKTFDGkRYLEHFEDRVTMVALTLAQGD--------ETLATQLTDEMLSGRFQPATPTFLNCGKQQRGELVSCFLLRI 174
Cdd:TIGR02504 6 YLLKDEDG-NIIESPEDLFRRVARALAAAEdkynspvwKQWYERFYDLMVNLGFIPNSPTLMNAGGTRLGQLSACFVLPV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 175 EDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHH 254
Cdd:TIGR02504 85 EDSMEDIFEALKEAALIFKRGGGVGYNFSTLRPKGDLVSGTGGVASGPVSFMRVFDSAAGVVKQGGTRRGAQMGILDVWH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 255 PDILRFLDTKRENadEKIRIKTLSLGVVipDITFRLAKENAQMALFSPYDVqrRYGKpfgdiaiserydeliadphvrkt 334
Cdd:TIGR02504 165 PDIEEFIEAKAKE--GKLQNFNISVGVT--DEFMEAVENDEEYELRNPRTG--EYKE----------------------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 335 yINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIA--GRINMSNLCSEILQvnsasryddnLDYThighdiSCNLGSLN 412
Cdd:TIGR02504 216 -VDARELWDKIVESAWKSAEPGVLFIDTINKWHTCPygGRINATNPCGEQPL----------LPYE------SCNLGSIN 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 413 IAHVMDSP-------DI---GRTVETAIRGLTAVSDMSHIrSVPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEAL 482
Cdd:TIGR02504 279 LAKFVKNDfgdeasfDFerlREVVRLATRFLDNVIDINVF-PLPEIAENTKKTRRIGLGIMGLADLLIKLGIPYDSEEAR 357
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 483 DFTNLYFYTITWHAVHTSMRLARERGkTFAGFAQSRYASGDYFTQYLQDDwqpktakvralfarsgimLPTremwlKLRD 562
Cdd:TIGR02504 358 ELAEEVMEFIADAAYRASAELAKERG-AFPLYDASKYPMGRAMGARIPSA------------------LPA-----EIRE 413
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 563 DVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIEIRKEGKTG---------------RVYYPAPFMT-NENLDMY 626
Cdd:TIGR02504 414 AIRKYGIRNAQLTTIAPTGTISLIAGTSSGIEPVFALVYFRNVTVGGellevnplvelalreLGYYSDEIVKyVDEKGTV 493
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2791323855 627 QD-------------AYDIGPEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIK 680
Cdd:TIGR02504 494 EGapgpeelpkvfvtAMDISPEDHVLMQAAIQPWVDSSISKTINMPSDATVEDVKAVYLEAWKLGLK 560
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
92-698 |
1.97e-71 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 251.40 E-value: 1.97e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 92 TFLGAWKFYTSYtLKTFDGKRyLEH---FEDRVTMvALTLAQGDETLATQLT--DEMLSGRFQPATPTFLNCGkQQRGEL 166
Cdd:PRK12365 379 SYMGVQNLYDRY-FNHHEGRR-LETpqiFWMRVSM-GLALNEGQDKTSWAITfyNLLSTFRYTPATPTLFNSG-MRHSQL 454
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 167 VSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAG 246
Cdd:PRK12365 455 SSCYLSTVQDDLVHIYKVISDNAMLSKWAGGIGNDWTAVRATGALIKGTNGKSQGVIPFIKVANDTAVAVNQGGKRKGAV 534
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 247 AVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFRLAKENAQMALFSPYDV---QRRYGKPFGdiAISERYD 323
Cdd:PRK12365 535 CVYLEVWHLDYEDFLELRKNTGDERRRTHDINTASWIPDLFFKRLQQKGTWTLFSPDDVpglHEAYGEEFE--KLYEEYE 612
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 324 ELIADPHVR-KTYINARDFFQTLAEIQFESGYPYIMFEDTVN--RANPIAGRINMSNLCSEILQVNSASRyddnldyTHI 400
Cdd:PRK12365 613 RKVDTGEIRlYKKVEAEDLWRKMLSMLYETGHPWMTFKDPSNirSAQDHKGVVRCSNLCTEILLNCSETE-------TAV 685
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 401 ghdisCNLGSLN-IAHV----MDSPDIGRTVETAIRGLTAVSDMShIRSVPSIAAGNAASHAIGLGQMNLHGYLAREGIA 475
Cdd:PRK12365 686 -----CNLGSINlVEHIvndgLDEEKLSETISIAIRILDNVIDIN-FYPTKEAKEANLAHRAIGLGVMGFQDALYKLNIS 759
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 476 YGSPEALDFTNLYFYTITWHAVHTSMRLARERGkTFAGFAQSRYASGdyftqYLQDDWQPKTAKVRalfARSGIMLPT-- 553
Cdd:PRK12365 760 YASQEAVEFADYSSELIAYYAILASSLLAKERG-TYSSYKGSKWDRG-----YLPIDTIELLKEYR---GEANLLMDTss 830
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 554 REMWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIEIrKEGKTGRVYYPAPFMTNE-------NLDMY 626
Cdd:PRK12365 831 RKDWEPVRSLIKEYGMRNSQLMAIAPTATISNIIGVTQSIEPTYKHLFV-KSNLSGEFTIPNVYLIEKlkklgiwDADML 909
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 627 QD------------------------AYDIGPEKIIDTYAEATRHVDQGLSLTLFF--PDtatTRDINKAQIYAWRKGIK 680
Cdd:PRK12365 910 DDlkyfdgslleieripdhlkkifltAFEIEPEWIIECASRRQKWIDMGQSLNLYLaePD---GKKLSNMYLTAWKKGLK 986
|
650
....*....|....*...
gi 2791323855 681 SLYYIRlrqlALEGTEIE 698
Cdd:PRK12365 987 TTYYLR----SSAATSVE 1000
|
|
| nrdA |
PHA02572 |
ribonucleoside-diphosphate reductase subunit alpha; Provisional |
52-705 |
1.12e-61 |
|
ribonucleoside-diphosphate reductase subunit alpha; Provisional
Pssm-ID: 222883 [Multi-domain] Cd Length: 753 Bit Score: 219.98 E-value: 1.12e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 52 ERLETLVREGYYDDAVLARYDRAFVLRLFEHA-HASGFRFqTFLGAWKFYTSYTLKTFDGKRYLEHFEDRVTMVALTLAQ 130
Cdd:PHA02572 102 DHISKCVNEGKYDPEILSKYSAEEITYLESFIdHDRDFEF-TYAGAMQLKEKYLVQDRSTGEIYETPQFAYMLIAMALHQ 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 131 gDETLATQLT------DEMLSGRFQPATPTFLNCGKQQRgELVSCFLLRIEDNMESIGRAVNSALQ-LSKRGGgVAFLLS 203
Cdd:PHA02572 181 -DEPKEDRLEhvirfyNAVSTRKISLPTPIMAGVRTPTR-QFSSCVVIESGDSLDSINKTAMAIVKyISKRAG-IGINAG 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 204 NLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVI 283
Cdd:PHA02572 258 MIRAEGSKIRGGEVRHTGVIPFWKHFQTAVKSCSQGGIRGGAATAYYPIWHLEVEDLLVLKNNKGVEENRIRHLDYGVQI 337
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 284 PDITFRLAKENAQMALFSPYDVQRR-YGKPFGDI-AISERYDELIADPHVRKTYINARDFFQTLAEIQFESGYPYIMFED 361
Cdd:PHA02572 338 NDLMYERFIKNDYITLFSPHDVGGElYDAYFADQdRFRELYEALEKDPSVRKKRIKAQELFLLLLKERSETGRIYIMFID 417
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 362 TVNRANPIAGRINMSNLCSEI-LQVNSASRYDDNldythiGHDISCNLGSLNIAHVMDSPDIGRTVETAIRGLTAVSDMs 440
Cdd:PHA02572 418 HCNNHSPFKDPIRQSNLCCEIaLPTKPLNHIDGE------GEIALCTLSAIVLGNFEDQDEIEELAEVAVRALDNLLDY- 490
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 441 hiRSVPSIAAGNA-ASHAIGLGQMNLHGYLAREGIAYGSPEAlDFTNLYFYTITWHAVHTSMRLARERGKTfAGFAQSRY 519
Cdd:PHA02572 491 --QDYPVPAALKAkKRRSLGVGVTNYAHYLAKNFASYEDANA-DLVHELFERLQYYLIKASNKLAKEKGAC-EYFSDTKY 566
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 520 ASGDyftqyLQDDWQPKTAKVralfarsgIMLPTREM-WLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVA 598
Cdd:PHA02572 567 SRGE-----LPIDWYKKKVDE--------LVAPKYNCdWESLREDLKKYGIRNSTLSALMPCESSSQVSNSTNGIEPPRG 633
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 599 KIEIrKEGKTGRVYYPAPfMTNENLDMYQDAYDI---GPEKIIDTYAEATRHVDQGLSL-TLFFPDTATTRDINKAQI-- 672
Cdd:PHA02572 634 PVSI-KKSKEGPFNQVVP-NVETLKDLYDLLWDLakkGNKGYLTQVAIMQKFVDQAISAnTSYDPENYPNGKVPMSVMld 711
|
650 660 670 680
....*....|....*....|....*....|....*....|..
gi 2791323855 673 ---YAWRKGIKSLYYIRLR------QLALEGTEIEGCVSCAL 705
Cdd:PHA02572 712 dllYFYYYGGKTLYYHNTRdgkgteDYEIETPKAEDCDSCKL 753
|
|
| PRK06539 |
PRK06539 |
ribonucleoside-diphosphate reductase subunit alpha; |
54-688 |
6.57e-56 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180610 [Multi-domain] Cd Length: 822 Bit Score: 204.77 E-value: 6.57e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 54 LETLVREGYYDDAVLARYDRAFVLRLFEHAHASGFRFqtfLGAWKFYTSYTLKTFDGKRyLE---HFEDRVTMvALTLAQ 130
Cdd:PRK06539 114 IEKGVAEGLLDSRLGGLFDLERLAAALDPTRDELLKY---IGVVTLNNRYGIRARNGDA-LEvpqYFWMRIAM-GLSLNE 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 131 GDET-LATQLTDEMLSGRFQPATPTFLNCGKQQrGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAG 209
Cdd:PRK06539 189 DDPTsSALAFYEKMSKLEYLAAGSTLVNAGTPY-PQLSNCFVMEMQDDIEHIAKTTRDVMWLTKGTGGIGLSVSKLRAQG 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 210 APIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFR 289
Cdd:PRK06539 268 SPIRSNNTTSTGPIPFMHTIDSVLRAVSRGGKKFGALCFYMENWHMDFPEFLDLRQNSGDPYRRTRTANTAVWISDEFMK 347
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 290 LAKENAQMALFSPY---DVQRRYGKPFgdiaiSERYDELIADPHVRK----TYINARDFFQT-LAEIQFESgYPYIMFED 361
Cdd:PRK06539 348 RVQNDEDWYLFDPLetpDLNELYGKAF-----SKRYAQYVEQAEAGRirmfKRITAREQFRAiLMSLQTTS-HPWLTWKD 421
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 362 TVN-RA-NPIAGRINMSNLCSEIlqvnSASRYDDNLDYthighdisCNLGSLNIA-HV----MDSPDIGRTVETAIRGLT 434
Cdd:PRK06539 422 TINnRAlNNNTGTIHLSNLCTEI----CLPQDRDNVSV--------CNLASINLSrHLadgeLDWAQLEESTRLAVRQLD 489
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 435 AVSDMShIRSVPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGkTFAGF 514
Cdd:PRK06539 490 NLIDIT-ASSVKEADFSNQQNRAIGLGVMGFTDMVERLGYSYESEEAYDLIDRIMEHISYAAIDESADLAAERG-AYPNF 567
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 515 AQSRYASG----DYFTQYLQDDWQPKTAKvralfaRSgimlpTREMWLKLRDDVmRYGIYNQNLQAVPPTGSISYINHAT 590
Cdd:PRK06539 568 EGSRWSRGmvpvDSIALLEADRGVPVDVN------RT-----TRLDWDALRAKV-RGGMRNATLMAIAPTASIGLVAGTT 635
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 591 SSIHP---------------------IVAKIE------------IRKEGKTGRV-YYPAPFMTNenldmYQDAYDIGPEK 636
Cdd:PRK06539 636 PGLDPqfsqifsrstssgkflevnrnLVADLKelglwetvreeiLRSQGDIQEIaAIPDEIKAL-----YRTSFQLSPYA 710
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*
gi 2791323855 637 IIDTYAEATRHVDQGLSLTLFFpdtaTTRDI-NKAQIY--AWRKGIKSLYYIRLR 688
Cdd:PRK06539 711 FLEVAARAQKWVDQAISRNMYL----ESRDIgDMMDIYtaAWEMGVKTTYYLHMK 761
|
|
| PRK08665 |
PRK08665 |
vitamin B12-dependent ribonucleotide reductase; |
111-680 |
1.98e-50 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236330 [Multi-domain] Cd Length: 752 Bit Score: 188.22 E-value: 1.98e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 111 KRYL------EHFEDRVTM---VALTLAQGD---------ETLATQLTDEMLSGRFQPATPTFLNCGKQQrGELVSCFLL 172
Cdd:PRK08665 22 KRYLkkdedgKPIETPEDMfrrVARTIAAAEliydskadvEALADRFYDLMTSLEFLPNSPTLMNAGREL-GQLSACFVL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 173 RIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHA 252
Cdd:PRK08665 101 PVGDSIEEIFDAVKHAALIHKSGGGTGFSFSRLRPKNDRVGSTGGVASGPVSFMRVFDAATEAIKQGGTRRGANMGILRV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 253 HHPDILRFLDTKRENADekirIKTLSLGVVIPDITFRLAKENAQMALFSPydvqrRYGKPFGDiaiserydeliadphvr 332
Cdd:PRK08665 181 DHPDIMEFITCKEDNGE----LTNFNISVAITEAFMEAVEADEEYDLINP-----RTGEVVGR----------------- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 333 ktyINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIA--GRINMSNLCSE--ILQvnsasrYDdnldythighdiSCNL 408
Cdd:PRK08665 235 ---LNAREVFDLIVEMAWENGEPGIVFIDRINRDNPTPhlGEIESTNPCGEqpLLP------YE------------SCNL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 409 GSLNIAHVMDSPDI-----GRTVETAIRGLTAVSDMSHIrSVPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALD 483
Cdd:PRK08665 294 GSINLSKMVKNGDVdweklREVVHLAVRFLDNVIDANKY-PLPQIEEMTKGNRKIGLGVMGWADMLIQLGIPYDSEEAVE 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 484 FTNLYFYTITWHAVHTSMRLARERGkTFAGFAQSRYAsgdyftqylqddwQPKTAKVRalfarsgimlptremwlklrdd 563
Cdd:PRK08665 373 LAEKVMKFIQDEAHAASRELAEERG-PFPNYEGSIYD-------------KDGLGPMR---------------------- 416
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 564 vmrygiyNQNLQAVPPTGSISYINHATSSIHPIVA------------KIEI--------RKEG-----------KTGRV- 611
Cdd:PRK08665 417 -------NATVTTIAPTGTISIIAGCSSGIEPLFAlsftrnvmdgerLVEVnpvfeaaaKEEGfyseelmekiaEKGSIq 489
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2791323855 612 ---YYPAP----FMTnenldmyqdAYDIGPEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIK 680
Cdd:PRK08665 490 didEVPEDvrrvFVT---------AHDISPEWHVRMQAAFQKHTDNAVSKTVNFPNEATIEDVREVYRLAYELGCK 556
|
|
| PRK07207 |
PRK07207 |
ribonucleoside-diphosphate reductase subunit alpha; |
65-696 |
6.47e-48 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 182.47 E-value: 6.47e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 65 DAVLARYDRAfvlRLFEHAHAS-GFRFqTFLGAWKFYTSYTLKTfDGKRYL--EHFEDRVTMvALTLAQGD-ETLATQLT 140
Cdd:PRK07207 273 DPKLAQFDLE---RLGAALDPErDLQF-TYLGLQTLYDRYFLHV-DGTRIElpQAFFMRVAM-GLALNEIDrEARAIEFY 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 141 DEMLSGRFQPATPTFLNCGKQqRGELVSCFLLRIEDNMESIGRAV-NSALqLSKRGGGVAFLLSNLREAGAPIKRIENQS 219
Cdd:PRK07207 347 NLLSSFDFMSSTPTLFNSGTL-RPQLSSCYLTTVPDDLDGIYEAIkDNAL-LSKFAGGLGNDWTPVRALGSHIKGTNGKS 424
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 220 SGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFRLAKENAQMAL 299
Cdd:PRK07207 425 QGVVPFLKVVNDTAVAVNQGGKRKGAVCAYLETWHLDIEEFLELRKNTGDDRRRTHDMNTANWIPDLFMKRVMEDGEWTL 504
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 300 FSPYDV---QRRYGKPFGdiAISERYDELIADPHVR--KTyINARDFFQTLAEIQFESGYPYIMFEDTVNRANPI--AGR 372
Cdd:PRK07207 505 FSPSEVpdlHDLFGKAFE--EAYTAYEAKAARGEIKlfKK-IPAVDLWRKMLSMLFETGHPWITFKDPCNLRSPQqhVGV 581
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 373 INMSNLCSEI-LQVNsasryDDnldythighDIS-CNLGSLNI-AHVMDSPDI-----GRTVETAIRGLTAVSDMSHIrS 444
Cdd:PRK07207 582 VHSSNLCTEItLNTS-----DD---------EIAvCNLGSVNLvAHIKDGAKLdheklKRTVSTAMRMLDNVIDINYY-A 646
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 445 VPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGktfagfaqsRYAS--G 522
Cdd:PRK07207 647 VPKARNSNLRHRPVGLGIMGFQDALYLLRIPYASDEAVEFADRSMEAVSYYAIWASTELAEERG---------RYSSyeG 717
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 523 DYFTQ-YLQDDWQPKTAKVRALFA---RSgimlpTREMWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHP--- 595
Cdd:PRK07207 718 SLWSRgILPIDSLKLLAEARGGYLevdRS-----STLDWDALRARIKKHGMRNSNCMAIAPTATISNIIGVSQSIEPtyq 792
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 596 -------------IVAKIEIR--KE-------------------GKTGRVyyPApfmtnENLDMYQDAYDIGPEKIIDTY 641
Cdd:PRK07207 793 nlyvksnlsgeftVVNPYLVRdlKArglwdevmvndlkyfdgslQRIDRI--PA-----DLKALYATAFEVDPRWLVEAA 865
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*..
gi 2791323855 642 AEATRHVDQGLSLTLFFpDTATTRDINkaQIY--AWRKGIKSLYYirLRQLALEGTE 696
Cdd:PRK07207 866 SRRQKWIDQAQSLNLYM-AGASGKKLD--ETYklAWLRGLKTTYY--LRTLGATHVE 917
|
|
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
102-691 |
5.97e-44 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 169.54 E-value: 5.97e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 102 SYTLKTfDGKrYLEHFEDRVTMVALTLAQGDETLATQlTDEMLSGR-FQPATPTFLNCGKQqRGELVSCFLLRI-EDNME 179
Cdd:PLN02437 154 SYLLKV-NGK-VVERPQHMLMRVSVGIHKDDIESAIK-TYHLMSQRwFTHASPTLFNAGTP-RPQLSSCFLICMkDDSIE 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 180 SIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGA-RQGAGAVYLHAHHPDIL 258
Cdd:PLN02437 230 GIYDTLKECAVISKSAGGIGLSVHNIRATGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGGkRKGAFAIYLEPWHADIF 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 259 RFLDTKRENADEKIRIKTLSLGVVIPDITFRLAKENAQMALFSPYDVQRR---YGKPFGdiAISERYDEliaDPHVRKTy 335
Cdd:PLN02437 310 EFLDLRKNHGKEEHRARDLFYALWIPDLFMERVQSNGDWSLFCPNEAPGLadcWGEEFE--RLYTKYER---EGKAKKV- 383
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 336 INARDFFQTLAEIQFESGYPYIMFEDTVNRANPIA--GRINMSNLCSEILQVNS-------------------------- 387
Cdd:PLN02437 384 VQAQQLWFAILESQIETGTPYMLFKDSCNRKSNQQnlGTIKSSNLCTEIIEYTSptetavcnlasialprfvrekgvple 463
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 388 ------------ASRYDDNLDYTHIGHDISCNLGslNIAHVMDSPdigrtVETAIRgltavSDMSHirsvpsiaagnaas 455
Cdd:PLN02437 464 shpsklvgslgsKNRYFDFEKLAEVTAVVTRNLN--KIIDVNYYP-----VETARR-----SNMRH-------------- 517
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 456 HAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERG--KTFAGFAQSRYAsgdyftqyLQDD- 532
Cdd:PLN02437 518 RPIGIGVQGLADAFILLGMPFDSPEAQQLNKDIFETIYYHALKASSELAAREGpyETYAGSPVSKGI--------LQPDm 589
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 533 WqpktakvralfarsGIMLPTREMWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIEIRKeGKTGRVY 612
Cdd:PLN02437 590 W--------------GVTPSGRWDWAALREMISKNGVRNSLLVAPMPTASTSQILGNNECFEPYTSNIYSRR-VLSGEFV 654
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 613 YPAPFMTNENLDM-------------------------------YQDAYDIGPEKIIDTYAEATRHVDQGLSLTLFFPDt 661
Cdd:PLN02437 655 VVNKHLLHDLTEMglwtptlknkiiaengsvqkipeipddlkaiYKTVWEIKQRTLVDMAADRGCYIDQSQSLNIHMDQ- 733
|
650 660 670
....*....|....*....|....*....|.
gi 2791323855 662 ATTRDINKAQIYAWRKGIKS-LYYIRLRQLA 691
Cdd:PLN02437 734 PNFGKLTSLHFYAWSKGLKTgMYYLRSRAAA 764
|
|
| PRK06406 |
PRK06406 |
vitamin B12-dependent ribonucleotide reductase; |
141-679 |
4.55e-42 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 163.87 E-value: 4.55e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 141 DEMLSGRFQPATPTFLNCGKQQrGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSS 220
Cdd:PRK06406 225 EVMSNLKFVPNSPTLMNAGTKL-GQLSACFVLPVPDSIEGIFNALKYTAMIHKSGGGTGFSFSRLRPKDDIVASTKGVAS 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 221 GVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKreNADEKIrIKTLSLGVVIPDitfrlakenaqmalf 300
Cdd:PRK06406 304 GPLSFMRIFDVTTDVIKQGGKRRGANMGILSYHHPDIMEFITSK--DSENKV-LSNFNISVAVTD--------------- 365
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 301 spydvqrrygkPFGDIAISERYDELIaDPHVRKTY--INARDFFQTLAEIQFESGYPYIMFEDTVNRANPIA--GRINMS 376
Cdd:PRK06406 366 -----------EFFDKLDNDDYYPLR-NPRNGKEVkrIKARQVWDLIITQAWKTGDPGVIFLDEINRKNPVKnlGEIEST 433
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 377 NLCSEilqvnsasryDDNLDYThighdiSCNLGSLNIAHV-----MDSPDIGRTVETAIRGLTAVSDMSHIrSVPSIAAG 451
Cdd:PRK06406 434 NPCGE----------QPLLPYE------SCNLGSINLSKFvengkIDWDRLRETVHIATRFLDNVIDANKF-PVPQIKEM 496
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 452 NAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGkTFAGFAQSryasgdyftqylqd 531
Cdd:PRK06406 497 TRMTRKIGLGVMGFADMLIKLGIPYNSEEALEIAEKVMKFINEESHRASQKLAEERG-VFPAWYGS-------------- 561
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 532 DWQPKTAKVRalfarsgimlptremwlklrddvmrygiyNQNLQAVPPTGSISYINHATSSIHPIVAKIEIRK------- 604
Cdd:PRK06406 562 EWEKKGIKMR-----------------------------NSTTTTIAPTGTISIIAGCSSSIEPLFAIAFVRHvlngqel 612
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 605 -------EGKTGRV-YYPAPFMTN-------ENLDMYQD-------AYDIGPEKIIDTYAEATRHVDQGLSLTLFFPDTA 662
Cdd:PRK06406 613 levnplfEEITRKRgLYSEELMRKvaetgnlQNIDVPEDikrifvtAHEIDPQWHVLMQATFQRYCDSGVSKTINLRYDA 692
|
570 580
....*....|....*....|
gi 2791323855 663 TTRDINKAQIYAWR---KGI 679
Cdd:PRK06406 693 TPEDIAKAYRLAKDlhcKGI 712
|
|
| RNR_N |
pfam08343 |
Ribonucleotide reductase N-terminal; This domain is found at the N-terminus of bacterial ... |
7-88 |
1.43e-33 |
|
Ribonucleotide reductase N-terminal; This domain is found at the N-terminus of bacterial ribonucleoside-diphosphate reductases (ribonucleotide reductases, RNRs) which catalyze the formation of deoxyribonucleotides. It occurs together with the RNR all-alpha domain (pfam00317) and the RNR barrel domain (pfam02867).
Pssm-ID: 429933 Cd Length: 82 Bit Score: 123.33 E-value: 1.43e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 7 YHALNAMLNLYDKAGHIQFDKDQQAIDAFFAAHVRPHSVTFASQHERLETLVREGYYDDAVLARYDRAFVLRLFEHAHAS 86
Cdd:pfam08343 1 YIALNNELNLYDENGKIQFDKDKEALEAYFKEHVNPNTVFFHSLKEKLDYLVENDYYEEEFLNKYSFEFIEELYKYAYSY 80
|
..
gi 2791323855 87 GF 88
Cdd:pfam08343 81 KF 82
|
|
| PRK09103 |
PRK09103 |
ribonucleoside-diphosphate reductase subunit alpha; |
168-684 |
4.83e-30 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181649 [Multi-domain] Cd Length: 758 Bit Score: 126.64 E-value: 4.83e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 168 SCFLLRIEDNMESIGrAVNSAL--QLSKRGG-GVAFllSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQG 244
Cdd:PRK09103 221 SCVLIECGDSLDSIN-ATSSAIvkYVSQRAGiGINA--GRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGG 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 245 AGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITF-RLAKeNAQMALFSPYDVQRRYGKPFGDIAISER-Y 322
Cdd:PRK09103 298 AATLFYPIWHLEVESLLVLKNNRGVEENRVRHMDYGVQINKLMYqRLIK-GGDITLFSPSDVPGLYDAFFADQDEFERlY 376
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 323 DELIADPHVRKTYINARDFFQTLAEIQFESGYPYIMFEDTVNRA---NPIAGRINMSNLCSEI-LQVNSASRYDDnldyt 398
Cdd:PRK09103 377 TKYEQDDSIRKKRVKAVELFSLMMQERASTGRIYIQNVDHCNTHspfDPKVAPVRQSNLCLEIaLPTKPLNDVND----- 451
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 399 HIGHDISCNLGSLNIAHVMDSPDIGRTVETAIRGLTAVSDMSHirsVPSIAAGNAA--SHAIGLGQMNLHGYLAREGIAY 476
Cdd:PRK09103 452 ENGEIALCTLSAFNLGAINSLDELEELADLAVRALDALLDYQD---YPIPAAKRGAmgRRTLGIGVINFAYYLAKNGVRY 528
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 477 GSPEALDFTNLYFYTITWHAVHTSMRLARERGKTFAgFAQSRYASG----DYFTQYLQDDWQPktakvralfarsgimlP 552
Cdd:PRK09103 529 SDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPW-FNETTYAQGilpiDTYKKDLDAICNE----------------P 591
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 553 TREMWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIEIrKEGKTGRVYYPAPfmTNENL-DMYQDAYD 631
Cdd:PRK09103 592 LHYDWETLREEIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSI-KASKDGILKQVVP--DYERLkDAYELLWE 668
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2791323855 632 IGPEkiiDTYAEAT----RHVDQGLSL------TLFFPDTATTRDINKAQIYAWRKGIKSLYY 684
Cdd:PRK09103 669 MPNN---DGYLQLVgimqKFVDQSISAntnydpSRFPSGKVPMKQLLKDLLTAYKFGVKTLYY 728
|
|
| PRK06556 |
PRK06556 |
vitamin B12-dependent ribonucleotide reductase; Validated |
139-604 |
3.41e-25 |
|
vitamin B12-dependent ribonucleotide reductase; Validated
Pssm-ID: 235828 [Multi-domain] Cd Length: 953 Bit Score: 111.60 E-value: 3.41e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 139 LTDEMLSGRFQPATPTFLNCGKQQRGELVSCFLLRIEDNMESIGR-AVNSALqLSKRGGGVAFLLSNLREAGapikriEN 217
Cdd:PRK06556 122 LTWLLLHQKFSFNSPVWFNVGTESPQQVSACFILSVDDSMESILNwYKEEGM-LFKGGSGTGTNLSRIRSSK------EL 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 218 QSSGVI---PV--MKMLeDAFSYANQLGA--RQGAGAVYLHAHHPDILRFLDTKrenADEKIRIKTL-------SLG--- 280
Cdd:PRK06556 195 LSGGGTasgPVsfMRGA-DASAGTIKSGGatRRAAKMVILDVDHPDIEEFIETK---AKEEDKIRALrdagydmDLGgea 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 281 ------------VVIPDiTFRLAKENaqmalfspydvqrryGKPFGDIAISerydeliaDPHVRKTYiNARDFFQTLAEI 348
Cdd:PRK06556 271 yssvqyqnannsVRVSD-EFMRAVEN---------------DGEFGLRART--------DGEVIETV-DAKELFRKIAEA 325
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 349 QFESGYPYIMFEDTVNR--ANPIAGRINMSNLCSEilqvnsasryddnldYTHIgHDISCNLGSLNIAHVM------DSP 420
Cdd:PRK06556 326 AWECADPGIQYDDTINDwhTCPESGRINASNPCSE---------------YMFL-DNSSCNLASLNLMKFLrddgtfDVE 389
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 421 DIGRTVETAIrglTAVSDMSHIRSVPS--IAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDF----TNLyfytITW 494
Cdd:PRK06556 390 SFRHAVELVI---TAMEISICFADFPTekIARNTRAFRQLGLGYANLGALLMATGLPYDSDGGRALaaaiTSL----MTG 462
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 495 HAVHTSMRLARERGkTFAGFAQSRyasgDYFTQYLQddwqpKTAKVRALFARSG-----IMLPTREMWlklrDDVMRYGI 569
Cdd:PRK06556 463 EAYRRSAELAGVVG-PFEGYARNA----EPHLRVMR-----KHAAANDAIRPLGevdaaLLEAAKEAW----DDALELGE 528
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 2791323855 570 YN--QNLQA--VPPTGSISY-INHATSSIHPIVAKIEIRK 604
Cdd:PRK06556 529 KNgyRNAQAsvLAPTGTIGFmMDCDTTGIEPDFALVKYKK 568
|
|
| PRK06948 |
PRK06948 |
ribonucleotide reductase-like protein; Provisional |
157-686 |
2.74e-24 |
|
ribonucleotide reductase-like protein; Provisional
Pssm-ID: 180772 [Multi-domain] Cd Length: 595 Bit Score: 107.96 E-value: 2.74e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 157 NCGKQQRGELVSCFL--LRIEDNMESIGRAVNSALQLSKR----GGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLE 230
Cdd:PRK06948 76 NAGAAPDQTMVNCFVhpIRAPAALTAVHPNLDRALDDARLtllmGGGIGYDFSAIPPADARPDADHPDSPGVCAALDRFD 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 231 DAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENAdekiRIKTLSLGVVIPDITFRLAKENAQMALFSPYDVQRRYG 310
Cdd:PRK06948 156 RICAALPFRDGRRGAQMAVLRCDHPDLLAFVAAKRGRA----RWTTFNLSVAVTDAFMQAVAQDLPWALRHRAPPRRAAG 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 311 KPfgdiaiserydelIADPHVRKTY--INARDFFQTLAEIQFESGYPYIMFEDTVNRANPIAG--RINMSNLCSEilqvN 386
Cdd:PRK06948 232 GA-------------LRGADGAWTYatVPARHLWREIVSAARDSAEPGLLFVDTIDAANPLREheRIDATNPCGE----Q 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 387 SASRYDdnldythighdiSCNLGSLNIAHVM------------DSPDIGRTVETAIRGLTAVSDMSHIrsvpSIAAGNAA 454
Cdd:PRK06948 295 PLPPYG------------SCVLGPIDLSRFVrhpfgvggeprfDFAALATAVRIQVRMLDNALDLTRW----PLAAHARE 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 455 SHA---IGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGkTFAGFAQSRYASGDYFtqylqd 531
Cdd:PRK06948 359 ARQkrrIGVGVTGLADALTMMRLRYDSPAAREMARYIASDLRHHAYAASAALAAERG-AYPLCDPAAHLDALRA------ 431
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 532 dwqpktakvralfarsGIMLPtremwLKLRDDVMRYGIYNQNLQAVPPTGSIS--YINHATSSIHPIVAKIEIRK-EGKT 608
Cdd:PRK06948 432 ----------------GPPLP-----HAVCHAIARHGLRNSHLLSFAPVGSVSlaFGDNCSPGIEPARAWIEHRPvRAGA 490
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 609 GRVyypaPFMTNENL----------------DMYQDAYDIGPEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQI 672
Cdd:PRK06948 491 GGA----RGMRAENHayrlfrslrgeraalpDYFVTAADVAPADHLAMRAALQPYVDAGISKTVTLPNHYSLAEVDALLF 566
|
570
....*....|....
gi 2791323855 673 YAWRKGIKSLYYIR 686
Cdd:PRK06948 567 QAWRAGLKGITIFR 580
|
|
| PRK08115 |
PRK08115 |
vitamin B12-dependent ribonucleotide reductase; |
138-680 |
2.05e-21 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236152 [Multi-domain] Cd Length: 858 Bit Score: 99.53 E-value: 2.05e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 138 QLTDEMLSGRFQPATPTFLNCGKQQRGELVSCFLLR-IEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIE 216
Cdd:PRK08115 158 KFYQELVNMNFVPAGRVLYGAGSKTDVTYFNCYVMPfVKDSREGISEHRKQVMEIMSRGGGVGTNGSTLRPRNTLARGVN 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 217 NQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKREN-------------------ADEKIRIKTL 277
Cdd:PRK08115 238 GKSSGSVSWLDDIAKLTHLVEQGGSRRGAQMIMLADWHPDILEFIISKMQNprilryllentedeqikrlVKEKLKFTPL 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 278 SL-------GVV----IPD----------------------------------ITFRLAKE-------NAQMALFSPyDV 305
Cdd:PRK08115 318 SEveeamyqAIVnyknIEGqggfdtkvikeaenklrtggtytvnnpefltganISVCLTKEfmeavenDEEYELRFP-DV 396
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 306 Q-------RRYGKPFGDIAISERYDELiadPHVRKTY--INARDFFQTLAEIQFESGYPYIMFEDTVN---RANPIAGRI 373
Cdd:PRK08115 397 EnyteeemEIYNEEWHEVGDVREWEKM---GYPVRTYrkIKAKELWNLINICATYSAEPGIFFIDNANemtNAKAYGQKV 473
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 374 NMSNLCSEilqvNSASRYDdnldythighdiSCNLGSLNIAH-------VMDSPDIGRTVETAIRGLTAVSDmshirSVP 446
Cdd:PRK08115 474 VATNPCGE----QPLAPYS------------VCNLAAINLANmadketkTVDYEKLKRTVEVGVRMQDNVID-----ATP 532
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 447 SIAAGNA----ASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGkTFAgfaqsryasg 522
Cdd:PRK08115 533 YFLEENKkqalGERRVGLGVMGLHDLLIYCETVYGSEEGNQLVDQIFETIATTAYRTSIELAKEKG-SFP---------- 601
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 523 dyftqYLQDDWQPKTAKVRALFARSGIMlptREMWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHP------- 595
Cdd:PRK08115 602 -----FLVGQTEEETAKLREAFINTGYM---KKMPEDIREDILKYGIRNSHLLTVAPTGSTGTMVGVSTGLEPyfsfsyy 673
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 596 --------IVAKIEIRKEGKTGrvyYPAPfMTNENLDMYQDAYDIGPEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDI 667
Cdd:PRK08115 674 rsgrlgkfIEVKADIVQEYLDK---HPEA-DENHLPEWFISAMELKPEAHADVQCIIQRWVDSSLSKTVNAPKGYTVEQV 749
|
650
....*....|...
gi 2791323855 668 NKAQIYAWRKGIK 680
Cdd:PRK08115 750 QKVYERLYRGGAK 762
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
405-699 |
4.18e-17 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 86.36 E-value: 4.18e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 405 SCNLGSLNIAHVMDSPDIGR----------TVETAIRGLTAVSDMSHIrSVPSIAAGNAASHAIGLGQMNLHGYLAREGI 474
Cdd:PRK08332 1307 SCNLASINLAKFVKYDENGKpyfdwdeyayVIQKVAKYLDNAIDVNKF-PLPEIDYNTKLTRRIGVGMMGLADALFKLGI 1385
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 475 AYGSPEALDFTNLYFYTITWHAVHTSMRLARERGkTFAGFAQSRYASGDYftqylqddwqpktaKVRALFARSGIMLPtr 554
Cdd:PRK08332 1386 PYNSEEGFKFMRKVTEYLTFYAYKYSVEAAKKRG-TFPLYEKTEYPKGEL--------------PVEGFYHPEIWNLP-- 1448
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 555 emWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIeIRKEGKTGRVYYPAP----------FMTNENLD 624
Cdd:PRK08332 1449 --WDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALV-YKKSVTVGEFYYVDPvfeaelkkrgLYSEELLK 1525
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 625 MYQDAYDI--GPEKI-----------IDTY------AEATRH--VDQGLSLTLFFPDTATTRDINKAQIYAWRKGIKSLY 683
Cdd:PRK08332 1526 KISDNYGSvqGLEEIpedmqrvfvtaLDIHwldhilAQANIQmwLTDSASKTINMINEATVEDVKAAYLIAHFLGCKGVT 1605
|
330
....*....|....*.
gi 2791323855 684 YIRLRQLALEGTEIEG 699
Cdd:PRK08332 1606 VYRDGSLSVQVYSVEG 1621
|
|
| Ribonuc_red_lgN |
pfam00317 |
Ribonucleotide reductase, all-alpha domain; |
92-160 |
2.58e-14 |
|
Ribonucleotide reductase, all-alpha domain;
Pssm-ID: 459758 [Multi-domain] Cd Length: 75 Bit Score: 68.42 E-value: 2.58e-14
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2791323855 92 TFLGAWKFYTSYTLKTFDGKRYlEHFEDRVTMVALTLAQ-----GDETLATQLTDEMLSGRFQPATPTFLNCGK 160
Cdd:pfam00317 2 TYLGAKVLEDRYLLKDEDGELL-ETPQDMFMRVALALAGaeleeDRLELAEEFYDLLSSLKFLPATPTLMNAGT 74
|
|
| PRK07562 |
PRK07562 |
vitamin B12-dependent ribonucleotide reductase; |
324-518 |
5.64e-11 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236049 [Multi-domain] Cd Length: 1220 Bit Score: 66.14 E-value: 5.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 324 ELIA--DPHVRKTyINARDFFQTLAEIQFESGYPYIMFEDTVN--RANPIAGRINMSNLCSEILqvnsasryddNLDyth 399
Cdd:PRK07562 418 NLTArtDGKVAKT-LKARDLWEKIGYAAWASADPGLQFNTTINdwHTCPASGPIRASNPCSEYM----------FLD--- 483
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 400 ighDISCNLGSLNIAHVMDsPDIGR----TVETAIRGLTAVSD----MSHIrsvPS--IAAGNAASHAIGLGQMNLHGYL 469
Cdd:PRK07562 484 ---DTACNLASLNLLTFRD-EDTKRfdveAYEHACRLWTVVLEisvlMAQF---PSkeIAELSYEFRTLGLGYANIGGLL 556
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 2791323855 470 AREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGkTFAGFAQSR 518
Cdd:PRK07562 557 MTMGIPYDSDEGRAICGALSAIMTGVAYATSAEMAKELG-PFPGYEKNA 604
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
202-379 |
6.02e-06 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 49.76 E-value: 6.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 202 LSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIrIKTLSLGV 281
Cdd:PRK08332 760 FSKLRPEGDIVGTTTGAASGPVSFMHLIDAVSDVIKQGGVRRGANMGILEIWHPDIEKFIHAKEKNIGTNV-LSNFNISV 838
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791323855 282 VIPDITFRLAKENAQMALFSPydvqrrygkpfgdiaiseRYDELIADphvrktyINARDFFQTLAEIQFESGYPYIMFED 361
Cdd:PRK08332 839 GIWEDFWEALKEGKKYPLINP------------------RTGEVVKE-------IDPKSLFEELAYMAWAKADPGVIFFD 893
|
170 180
....*....|....*....|..
gi 2791323855 362 TVNRANPI----AGRINMSNLC 379
Cdd:PRK08332 894 VINRRNVLkeakGGPIRATNPC 915
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
143-197 |
7.70e-06 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 49.38 E-value: 7.70e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 2791323855 143 MLSGRFQPATPTFLNCGKQQrGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGG 197
Cdd:PRK08332 248 MTNQIFMPNTPALINSGRPL-GMLSACFVVPIEDDMESIMKAAHDVAMIQKAGGG 301
|
|
| |
