Thermus thermophilus TTHA0104 and related proteins, cupin domain; This family contains bacterial proteins including TTHA0104 (also called TT1209), a putative antibiotic synthesis protein from Thermus thermophilus. TTHA0104 is a cupin-like protein. The cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin (cupa is the Latin term for small barrel).

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2786578307   6 VEDQRQQLVAGRLVVILADVPHSIKNNGEQRARFL 40
Cdd:cd06122    63 VGDEERELGAGEAVLAPAGVPHGVRNTGAERLVLL 97

Thermus thermophilus TTHA0104 and related proteins, cupin domain; This family contains bacterial proteins including TTHA0104 (also called TT1209), a putative antibiotic synthesis protein from Thermus thermophilus. TTHA0104 is a cupin-like protein. The cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin (cupa is the Latin term for small barrel).

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2786578307   6 VEDQRQQLVAGRLVVILADVPHSIKNNGEQRARFL 40
Cdd:cd06122    63 VGDEERELGAGEAVLAPAGVPHGVRNTGAERLVLL 97

Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2786578307   5 VVEDQRQQLVAGRLVVILADVPHSIKNNGEQRARFLALF 43
Cdd:COG0662    62 TIGDEEVELKAGDSVYIPAGVPHRLRNPGDEPLELLEVQ 100

Uncharacterized conserved protein, cupin superfamily [Function unknown];

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2786578307   5 VVEDQRQQLVAGRLVVILADVPHSIKNNGEQRARFLA 41
Cdd:COG3837    64 RIGGEEYVLEPGDSVGFPAGVPHRLRNRGDEPARYLV 100

RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP (deoxythymidine diphosphates)-4-dehydrorhamnose 3,5-epimerase)-like cupins. RmlC is a dTDP-sugar isomerase involved in the synthesis of L-rhamnose, a saccharide required for the virulence of some pathogenic bacteria. Cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin ('cupa' is the Latin term for small barrel). The active site of members of this superfamily is generally located at the center of a conserved barrel and usually includes a metal ion. The different functional classes in this superfamily include single domain bacterial isomerases and epimerases involved in the modification of cell wall carbohydrates, two domain bicupins such as the desiccation-tolerant seed storage globulins, and multidomain nuclear transcription factors involved in legume root nodulation.

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 2786578307  5 VVEDQRQQLVAGRLVVILADVPHSIKNNGEQRARFLALF 43
Cdd:cd02208   35 LDDGETVELKAGDIVLIPPGVPHSFVNTSDEPAVFLVVS 73

uncharacterized Methanocaldococcus jannaschii Moth_1897 and related proteins, cupin domain; This family includes archaeal and bacterial proteins homologous to Moth_1897, a Methanocaldococcus jannaschii protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.

                         10        20        30
                 ....*....|....*....|....*....|...
gi 2786578307  8 DQRQQLVAGRLVVILADVPHSIKNNGEQRARFL 40
Cdd:cd06984   48 EEKQEVEADTLIESPANIPHCLYNESDADLRVL 80

Thermotoga maritima TM1459 and related proteins, cupin domain; This family includes bacterial and archaeal proteins homologous to Thermotoga maritima TM1459, a manganese-containing cupin that has been shown to cleave C=C bonds in the presence of alkylperoxide as oxidant in vitro. Its biological function is still unknown. This family also includes Halorhodospira halophila Hhal_0468. Structures of these proteins show a cupin fold with a conserved "jelly roll-like" beta-barrel fold that form a homodimer.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 2786578307  4 AVVEDQRQQLVAGRLVVILADVPHSIKNNGEQRARFLALFPS 45
Cdd:cd02222   50 VVIGGEEYPVKPGDVVYIPPNEPHQFRNTGDEPLGFLCIVPK 91