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Conserved domains on  [gi|2773514301|ref|WP_367361449|]
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lytic transglycosylase domain-containing protein [Syntrophus sp. (in: bacteria)]

Protein Classification

lytic transglycosylase domain-containing protein( domain architecture ID 11432856)

lytic transglycosylase domain-containing protein similar to Bacillus subtilis bifunctional muramidase/lytic transglycosylase CwlQ that cleaves the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine (MurNAc-GlcNAc) in peptidoglycan, producing both N-acetylmuramic acid and 1,6-anhydro-N-acetylmuramic acid

Gene Ontology:  GO:0016787|GO:0000270|GO:0008933|GO:0071555
PubMed:  8765311|7479697|9723170

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 1-199 2.10e-54

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 173.64  E-value: 2.10e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301   1 MPQRTGQVHPAGQTVLSSMAGSAADLYMFRDGDAPAGYAPVSDSKRRLSSMKGFYPGKNSFAVPKGAGSAVRSSDYGKAI 80
Cdd:COG0741    28 AAAAAAALAAAAAALAAAAAAAAGAAAAAASAAAGGPALAAALAAADALAAFAAIAALAAELLALAALLLRRPLPYLPLI 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301  81 KSACRRYTVDPALVRAVIMAESNFNPAAVSPKGAMGLMQLMPDTAREMGV--------SNPFDPVENIHGGVGYLSRLLK 152
Cdd:COG0741   108 EEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPATARRLGLklglgpspDDLFDPETNIRAGAAYLRELLD 187

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2773514301 153 SLNGDLFLALAAYNAGPERVKSY--------KGIPPFQETWLYIKRVLDYYQFYK 199
Cdd:COG0741   188 RFDGDLVLALAAYNAGPGRVRRWlrrngdrdGEIIPYAETRNYVKKVLANYAIYR 242
 
Name Accession Description Interval E-value
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 1-199 2.10e-54

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 173.64  E-value: 2.10e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301   1 MPQRTGQVHPAGQTVLSSMAGSAADLYMFRDGDAPAGYAPVSDSKRRLSSMKGFYPGKNSFAVPKGAGSAVRSSDYGKAI 80
Cdd:COG0741    28 AAAAAAALAAAAAALAAAAAAAAGAAAAAASAAAGGPALAAALAAADALAAFAAIAALAAELLALAALLLRRPLPYLPLI 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301  81 KSACRRYTVDPALVRAVIMAESNFNPAAVSPKGAMGLMQLMPDTAREMGV--------SNPFDPVENIHGGVGYLSRLLK 152
Cdd:COG0741   108 EEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPATARRLGLklglgpspDDLFDPETNIRAGAAYLRELLD 187

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2773514301 153 SLNGDLFLALAAYNAGPERVKSY--------KGIPPFQETWLYIKRVLDYYQFYK 199
Cdd:COG0741   188 RFDGDLVLALAAYNAGPGRVRRWlrrngdrdGEIIPYAETRNYVKKVLANYAIYR 242
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 91-196 1.03e-51

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 162.00  E-value: 1.03e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301  91 PALVRAVIMAESNFNPAAVSPKGAMGLMQLMPDTAREMG---VSNPFDPVENIHGGVGYLSRLLKSLNGDLFLALAAYNA 167
Cdd:cd00254     1 PALVLAVIRVESGFNPRAVSPAGARGLMQLMPGTARDLGrrgVDDLFDPEENIRAGARYLRELLDRFGGDLELALAAYNA 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2773514301 168 GPERVKSYKG--IPPFQETWLYIKRVLDYYQ 196
Cdd:cd00254    81 GPGAVDRWGGgeVPPYKETRNYVQRVLAYYQ 111
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 80-187 4.92e-38

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 127.42  E-value: 4.92e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301  80 IKSACRRYTVDPALVRAVIMAESNFNPAAVSPKGAMGLMQLMPDTAREMG------VSNPFDPVENIHGGVGYLSRLLKS 153
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLGlrvnpgVDDLFDPEKNIKAGTKYLKELYKQ 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2773514301 154 LNGDLFLALAAYNAGPERVKSYKGIPPFQETWLY 187
Cdd:pfam01464  81 YGGDLWLALAAYNAGPGRVRKWIKNAGAKDKKLL 114
PRK11619 PRK11619
lytic murein transglycosylase; Provisional
 85-199 6.97e-25

lytic murein transglycosylase; Provisional


Pssm-ID: 183236 [Multi-domain]  Cd Length: 644  Bit Score: 101.29  E-value: 6.97e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301  85 RRYTVDPALVRAVIMA----ESNFNPAAVSPKGAMGLMQLMPDTAR---EM----GVSNP---FDPVENIHGGVGYLSRL 150
Cdd:PRK11619  484 RRYTSGKGIPQSYAMAiarqESAWNPKARSPVGASGLMQIMPGTAThtvKMfsipGYSSSsqlLDPETNINIGTSYLEYV 563

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2773514301 151 LKSLNGDLFLALAAYNAGPERVKSYKG--------------IpPFQETWLYIKRVLDYYQFYK 199
Cdd:PRK11619  564 YQQFGNNRILASAAYNAGPGRVRTWLGnsagridavafvesI-PFSETRGYVKNVLAYDAYYR 625
 
Name Accession Description Interval E-value
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 1-199 2.10e-54

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 173.64  E-value: 2.10e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301   1 MPQRTGQVHPAGQTVLSSMAGSAADLYMFRDGDAPAGYAPVSDSKRRLSSMKGFYPGKNSFAVPKGAGSAVRSSDYGKAI 80
Cdd:COG0741    28 AAAAAAALAAAAAALAAAAAAAAGAAAAAASAAAGGPALAAALAAADALAAFAAIAALAAELLALAALLLRRPLPYLPLI 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301  81 KSACRRYTVDPALVRAVIMAESNFNPAAVSPKGAMGLMQLMPDTAREMGV--------SNPFDPVENIHGGVGYLSRLLK 152
Cdd:COG0741   108 EEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPATARRLGLklglgpspDDLFDPETNIRAGAAYLRELLD 187

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2773514301 153 SLNGDLFLALAAYNAGPERVKSY--------KGIPPFQETWLYIKRVLDYYQFYK 199
Cdd:COG0741   188 RFDGDLVLALAAYNAGPGRVRRWlrrngdrdGEIIPYAETRNYVKKVLANYAIYR 242
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 91-196 1.03e-51

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 162.00  E-value: 1.03e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301  91 PALVRAVIMAESNFNPAAVSPKGAMGLMQLMPDTAREMG---VSNPFDPVENIHGGVGYLSRLLKSLNGDLFLALAAYNA 167
Cdd:cd00254     1 PALVLAVIRVESGFNPRAVSPAGARGLMQLMPGTARDLGrrgVDDLFDPEENIRAGARYLRELLDRFGGDLELALAAYNA 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2773514301 168 GPERVKSYKG--IPPFQETWLYIKRVLDYYQ 196
Cdd:cd00254    81 GPGAVDRWGGgeVPPYKETRNYVQRVLAYYQ 111
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 76-196 2.32e-47

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 152.28  E-value: 2.32e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301  76 YGKAIKSACRRYTVDPALVRAVIMAESNFNPAAVSPKGAMGLMQLMPDTAR----EMGVSNP-----FDPVENIHGGVGY 146
Cdd:cd16896     4 YREYIEKYAKEYGVDPLLVAAVIKVESNFNPNAVSSKGAIGLMQIMPETAEwiaeKLGLEDFseddlYDPETNIRLGTWY 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2773514301 147 LSRLLKSLNGDLFLALAAYNAGPERVK--------SYKGIP----PFQETWLYIKRVLDYYQ 196
Cdd:cd16896    84 LSYLLKEFDGNLVLALAAYNAGPGNVDkwlkdggwSGDGKTldqiPFPETRHYVKKVLKNYK 145
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 76-199 2.14e-46

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 149.93  E-value: 2.14e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301  76 YGKAIKSACRRYTVDPALVRAVIMAESNFNPAAVSPKGAMGLMQLMPDTAREM----GVSNP-----FDPVENIHGGVGY 146
Cdd:cd13401     6 YRDLVERAAKKNGLDPALVYAIIRQESAFDPDAVSPAGALGLMQLMPATAKDVakklGLPYYsprdlFDPEYNIRLGSAY 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2773514301 147 LSRLLKSLNGDLFLALAAYNAGPERV----KSYKGIP--------PFQETWLYIKRVLDYYQFYK 199
Cdd:cd13401    86 LAELLDRFDGNPVLALAAYNAGPGRVrrwlKRRGDLDpdlwietiPFSETRNYVKRVLENYVVYR 150
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 80-187 4.92e-38

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 127.42  E-value: 4.92e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301  80 IKSACRRYTVDPALVRAVIMAESNFNPAAVSPKGAMGLMQLMPDTAREMG------VSNPFDPVENIHGGVGYLSRLLKS 153
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLGlrvnpgVDDLFDPEKNIKAGTKYLKELYKQ 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2773514301 154 LNGDLFLALAAYNAGPERVKSYKGIPPFQETWLY 187
Cdd:pfam01464  81 YGGDLWLALAAYNAGPGRVRKWIKNAGAKDKKLL 114
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 80-199 6.33e-37

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 126.11  E-value: 6.33e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301  80 IKSACRRYTVDPALVRAVIMAESNFNPAAVSPKGAMGLMQLMPDTAREMGVSNPFDPVENIHGGVGYLSRLLKSLNGD-- 157
Cdd:cd13403     1 FKKYAEKYGFDWRLLAAQAYQESRFNPNARSPAGARGLMQLMPSTARELGVNDRLDPEQNIHAGAKYLRYLRDRFPPDid 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301 158 ----LFLALAAYNAGPERV-------KSYKGIP---------------PF------------QETWLYIKRVLDYYQFYK 199
Cdd:cd13403    81 epdrLKFALAAYNAGPGHVrdarrlaKKYGLNPnvwfdnvevlpllksPYydpvvkygyargRETVNYVRNIRKYYDAYK 160
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 72-200 1.20e-36

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 132.11  E-value: 1.20e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301  72 RSSDYGKAIKSACRRYTVDPALVRAVIMAESNFNPAAVSPKGAMGLMQLMPDTAREMGVSNPFDPVENIHGGVGYLSRLL 151
Cdd:COG4623   260 RLPPYDPLFEKYAEEYGLDWRLLAALAYQESHWNPRARSPTGARGLMQLMPATAKELGVDDRLDPEQSIRAGAKYLRWLY 339

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301 152 KSLN------GDLFLALAAYNAGPERV-------KSYKGIPPF-------------------QETWLYIKRVLDYYQFYK 199
Cdd:COG4623   340 DRFPeaidepDRWWFALAAYNAGPGHVqdarrlaKKQGLDPDRwfdveksqpkyydtgyargRETVNYVPNIRAYYDIYK 419


                  .
gi 2773514301 200 G 200
Cdd:COG4623   420 R 420
PRK11619 PRK11619
lytic murein transglycosylase; Provisional
 85-199 6.97e-25

lytic murein transglycosylase; Provisional


Pssm-ID: 183236 [Multi-domain]  Cd Length: 644  Bit Score: 101.29  E-value: 6.97e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301  85 RRYTVDPALVRAVIMA----ESNFNPAAVSPKGAMGLMQLMPDTAR---EM----GVSNP---FDPVENIHGGVGYLSRL 150
Cdd:PRK11619  484 RRYTSGKGIPQSYAMAiarqESAWNPKARSPVGASGLMQIMPGTAThtvKMfsipGYSSSsqlLDPETNINIGTSYLEYV 563

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2773514301 151 LKSLNGDLFLALAAYNAGPERVKSYKG--------------IpPFQETWLYIKRVLDYYQFYK 199
Cdd:PRK11619  564 YQQFGNNRILASAAYNAGPGRVRTWLGnsagridavafvesI-PFSETRGYVKNVLAYDAYYR 625
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 79-196 1.70e-24

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 94.16  E-value: 1.70e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301  79 AIKSACRRYTVDPALVRAVIMAESNFNPAAVSPKGAMGLMQLMPDTA------------REMGVSNPFDPVENIHGGVGY 146
Cdd:cd16893     2 IVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAgrdvyrllggkgGLPSKSYLFDPENNIDIGTAY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301 147 LS----RLLKSLNGD---LFLALAAYNAGPERV-KSYKGIP-----------------------PFQETWLYIKRVLDYY 195
Cdd:cd16893    82 LHilqnRYLKGIKNPksrEYCAIAAYNGGAGNVlRTFSSDRkkaiskinrlspdevyqhltkklPAAETRNYLKKVLKAK 161


                  .
gi 2773514301 196 Q 196
Cdd:cd16893   162 K 162
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 87-169 1.84e-21

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 84.67  E-value: 1.84e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301  87 YTVDPALVRAVIMAESNFNPAAV-SPKGAMGLMQLMPDTAREMGVS-------NPFDPVENIHGGVGYLSRLLKSLN--- 155
Cdd:cd13399     1 YGVPPGILAAILGVESGFGPNAGgSPAGAQGIAQFMPSTWKAYGVDgngdgkaDPFNPEDAIASAANYLCRHGWDLNafl 80

                          90
                  ....*....|....*
gi 2773514301 156 -GDLFLALAAYNAGP 169
Cdd:cd13399    81 gEDNFLALAAYNAGP 95
MltD-like cd16894
Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases ...
 99-175 6.14e-21

Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases (LT) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc). Membrane-bound lytic murein transglycosylase D protein (MltD) family members may have one or more small LysM domains, which may contribute to peptidoglycan binding. Unlike the similar "goose-type" lysozymes, LTs also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381615 [Multi-domain]  Cd Length: 129  Bit Score: 83.72  E-value: 6.14e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301  99 MAESNFNPAAVSPKGAMGLMQLMPDTAREMGVSNP------FDPVENIHGGVGYLSRlLKSLNGDLFLALAAYNAGPERV 172
Cdd:cd16894    15 LVESGFNPDAVSSAGAAGLWQFMPATAREYGLRVDswvderRDPEKSTRAAARYLKD-LYKRFGDWLLALAAYNAGEGRV 93


                  ...
gi 2773514301 173 KSY 175
Cdd:cd16894    94 RRA 96
PRK10859 PRK10859
membrane-bound lytic murein transglycosylase MltF;
75-168 2.15e-18

membrane-bound lytic murein transglycosylase MltF;


Pssm-ID: 236778 [Multi-domain]  Cd Length: 482  Bit Score: 82.23  E-value: 2.15e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301  75 DYGKAIKSACRryTVDPALVRAVIMAESNFNPAAVSPKGAMGLMQLMPDTAREMGVSNPFDPVENIHGGVGYLSRLLK-- 152
Cdd:PRK10859  289 KYQPLFEKYAG--ELDWRLLAAIAYQESHWNPQATSPTGVRGLMMLTRNTAQSMGVTDRLDPEQSIRGGARYLQDLMErl 366

                          90       100
                  ....*....|....*....|
gi 2773514301 153 --SLNGD--LFLALAAYNAG 168
Cdd:PRK10859  367 peSIPEPerIWFALAAYNIG 386
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
71-168 1.02e-15

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 73.93  E-value: 1.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301  71 VRSSDYGKAIKSACRRYTVDPALVRAVIMAESNFNPAAVSPKGAMGLMQLMPDTA-----REMGVS-NP-----FDPVEN 139
Cdd:PRK11671  187 KRAHKYLPMVRKASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTAgkdvfRMKGKSgQPsrsylFDPANN 266

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2773514301 140 IHGGVGYLSRLLKSLNGDL-------FLALAAYNAG 168
Cdd:PRK11671  267 IDTGTAYLAILQNVYLGGItnptsrrYAVITAYNGG 302
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 87-196 1.98e-13

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 63.70  E-value: 1.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301  87 YTVDPALVRAVIMAESNFNPAAVSPKG----AMGLMQL----MPDTAReMGVSNP---FDPVENIHGGVGYLSRLLKSLn 155
Cdd:cd13400     1 YGVPPRLLRAIAKVESGFNPNAINRNKngsyDIGLMQInsiwLPELAR-YGITREellNDPCTNIYVGAWILARNIKRY- 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2773514301 156 GDLFLALAAYNAGPervksykgiPPFQETwlYIKRVLDYYQ 196
Cdd:cd13400    79 GNTWKAVGAYNSGT---------PKKNDK--YARKVYRIYR 108
PHA00368 PHA00368
internal virion protein D
 74-173 4.05e-11

internal virion protein D


Pssm-ID: 222785 [Multi-domain]  Cd Length: 1315  Bit Score: 61.34  E-value: 4.05e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301   74 SDYGKAIKSACRRYTVDPALVRAVIMAESNFNPAAVSPKGAMGLMQLMPDTAREMGV----SNPFDPVENIHGGVGYLSR 149
Cdd:PHA00368     9 SEYDGLFQKAADAHGVSYDLLRKVGWDESRFNPTAKSPTGPKGLMQFTKATAKALGLivddDDRLDPELAIDAGARYLAD 88

                           90       100
                   ....*....|....*....|....
gi 2773514301  150 LLKSLNGDLFLALAAYNAGPERVK 173
Cdd:PHA00368    89 LVGKYDGDELKAALAYNQGEGRLG 112
mltD PRK10783
membrane-bound lytic murein transglycosylase D; Provisional
 101-192 1.37e-09

membrane-bound lytic murein transglycosylase D; Provisional


Pssm-ID: 182727 [Multi-domain]  Cd Length: 456  Bit Score: 56.67  E-value: 1.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301 101 ESNFNPAAVSPKGAMGLMQLMPDTAREMGVSNP------FDPVENIHGGVGYLSRLLKSLNGDLFLALAAYNAGPERV-- 172
Cdd:PRK10783  128 ESAFDPHATSGANAAGIWQIIPSTGRNYGLKQTrwydarRDVVASTTAALDMMQRLNKMFDGDWLLTVAAYNSGEGRVmk 207

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2773514301 173 -----KSyKGIP--------PfQETWLYIKRVL 192
Cdd:PRK10783  208 aikanKA-KGKPtdfwslslP-RETKIYVPKML 238
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
87-150 1.86e-09

membrane-bound lytic murein transglycosylase EmtA;


Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 54.97  E-value: 1.86e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2773514301  87 YTVDPALVRAVIMAESNFNPAAVSPKGAMGLMQLMPDTA-----REMG------VSNPFDPVENIHGGVGYLSRL 150
Cdd:PRK15470   50 WGVDPQLITAIIAIESGGNPNAVSKSNAIGLMQLKASTSgrdvyRRMGwsgeptTSELKNPERNISMGAAYLNIL 124
GEWL cd01021
Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; ...
 80-178 1.39e-08

Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; GEWL) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc). Mammals have two lysozymes. This family corresponds to human and mouse lysozyme G-like protein 2.


Pssm-ID: 381601 [Multi-domain]  Cd Length: 174  Bit Score: 52.22  E-value: 1.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301  80 IKSACRRYTVDPALVRAVIMAESNFNpAAVSPKG------AMGLMQLmpDTaREMGVSNPFDPVENIHGGVGYLSRLLK- 152
Cdd:cd01021    41 IKQVGKKLCIDPALIAAIISRESRAG-AALDKNGwgdhgnGFGLMQV--DK-RYHPPKGAWDSEEHIEQATGILIDFIKt 116

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2773514301 153 --------SLNGDLFLALAAYNAGPERVKSYKGI 178
Cdd:cd01021   117 vqrkhpswSPEQQLKGGIAAYNAGVGNVQSYAGM 150
PHA00658 PHA00658
putative lysin
 110-174 2.93e-08

putative lysin


Pssm-ID: 106967 [Multi-domain]  Cd Length: 720  Bit Score: 52.90  E-value: 2.93e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2773514301 110 SPKGAMGLMQLMPDTAREMG--VSNPFD-------PVENIHGGVGYLSRLLKSLNGDLFLALAAYNAGPERVKS 174
Cdd:PHA00658  326 SPKGAVGIAQVMPDTAPEAAklAGLPWDenryrndAAYNRALGMAYFQKQLRDFGGDLPKAYAAYNAGPGALQS 399
Lyz-like cd00442
lysozyme-like domains; This family contains several members, including soluble lytic ...
 96-140 5.70e-07

lysozyme-like domains; This family contains several members, including soluble lytic transglycosylases (SLT), goose egg-white lysozymes (GEWL), hen egg-white lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, chitosanases, and pesticin. Typical members are involved in the hydrolysis of beta-1,4- linked polysaccharides.


Pssm-ID: 381596 [Multi-domain]  Cd Length: 59  Bit Score: 45.09  E-value: 5.70e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2773514301  96 AVIMAESNFNP--AAVSPKGAMGLMQLMPDTAREMGVSNP---FDPVENI 140
Cdd:cd00442     4 AIIGQESGGNKpaNAGSGSGAAGLFQFMPGTWKAYGKNSSsdlNDPEASI 53
PRK15328 PRK15328
type III secretion system invasion protein IagB;
83-201 1.04e-03

type III secretion system invasion protein IagB;


Pssm-ID: 185228 [Multi-domain]  Cd Length: 160  Bit Score: 38.31  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301  83 ACRRYTVDPALVRAVIMAESNFNPAAV--SPKGA--MGLMQL----MPDTaREMGVSNP---FDPVENIHGGVGYLSRLL 151
Cdd:PRK15328   25 AEKMFNIESELLYAIAQQESAMKPGAIghNRDGStdLGLMQInsfhMKRL-KKMGISEKqllQDPCISVIVGASILSDMM 103

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2773514301 152 KsLNGDLFLALAAYNAG--PERVKSYKgippfqetwLYIKRVLDYYQFYKGM 201
Cdd:PRK15328  104 K-IYGYSWEAVGAYNAGtsPKRSDIRK---------RYAKKIWENYRKLKGM 145
PRK13722 PRK13722
lytic transglycosylase; Provisional
 83-168 3.96e-03

lytic transglycosylase; Provisional


Pssm-ID: 184274 [Multi-domain]  Cd Length: 169  Bit Score: 36.60  E-value: 3.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2773514301  83 ACRRYTVDPALVRAVIMAESNF--NPAAVSPKGAM--GLMQLMPDTAREM---GVSNPF---DPVENIHGGVGYLSRLLK 152
Cdd:PRK13722   26 AGRDYKIDPDLLRAISWKESRYrvNAIGINPVTGYgsGLMQVDSQHFNELaryGIKPEHlttDPCMNIYTGAYYLAIAFK 105

                          90
                  ....*....|....*.
gi 2773514301 153 SLnGDLFLALAAYNAG 168
Cdd:PRK13722  106 KW-GVSWEAVGAYNAG 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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