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Conserved domains on  [gi|2770181927|ref|WP_366567441|]
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ROK family transcriptional regulator [Actinacidiphila alni]

Protein Classification

ROK family transcriptional regulator( domain architecture ID 12122468)

NagC/ROK (Repressor, ORF, Kinase) family transcriptional regulator is involved in carbohydrate-dependent transcriptional control; contains a DNA-binding helix-turn-helix (HTH) domain

CATH:  3.30.420.40|1.10.10.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0005524|GO:0003677
PubMed:  20512568|17979299|7952186|15808743|2644244|8831795|7781919|8800467
SCOP:  3000034|4000330|3000092

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 74-377 1.09e-95

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


:

Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 287.95  E-value: 1.09e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  74 VPSAGYAIGADIGHQHVRVILCDLFGEVLWEHWVAKDVDRAPDETLDLVAVLVGRALQETGVGRERVLGIGAGIASPVEI 153
Cdd:COG1940     1 NPDAGYVIGIDIGGTKIKAALVDLDGEVLARERIPTPAGAGPEAVLEAIAELIEELLAEAGISRGRILGIGIGVPGPVDP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 154 GSGALGAEGIMPGWVGLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGAR 233
Cdd:COG1940    81 ETGVVLNAPNLPGWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGAN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 234 GLAGEIGHLPLITDGLICRCGNRGCLETVASPVAIARLLSESWG-QTVAPRDLPALIRERNSGALRAVRDAGDAVGRALA 312
Cdd:COG1940   161 GNAGEIGHMPVDPDGPLCGCGNRGCLETYASGPALLRRARELGGaEKLTAEELFAAARAGDPLALEVLDEAARYLGIGLA 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2770181927 313 ALVTLLNPSLVVVGGDLAAAGADILEPMRAGVLRHTLPSAAESVEIVTGGLGDGAEVRGAAGLVL 377
Cdd:COG1940   241 NLINLLDPEVIVLGGGVSAAGDLLLEPIREALAKYALPPAREDPRIVPASLGDDAGLLGAAALAL 305
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 9-57 1.33e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


:

Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 39.49  E-value: 1.33e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2770181927   9 LRVLEALHTSPRSSRPELVRVTGLSRATVSSLIADLITVGLVTEDESPE 57
Cdd:pfam12802   8 FRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPA 56
 
Name Accession Description Interval E-value
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 74-377 1.09e-95

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 287.95  E-value: 1.09e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  74 VPSAGYAIGADIGHQHVRVILCDLFGEVLWEHWVAKDVDRAPDETLDLVAVLVGRALQETGVGRERVLGIGAGIASPVEI 153
Cdd:COG1940     1 NPDAGYVIGIDIGGTKIKAALVDLDGEVLARERIPTPAGAGPEAVLEAIAELIEELLAEAGISRGRILGIGIGVPGPVDP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 154 GSGALGAEGIMPGWVGLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGAR 233
Cdd:COG1940    81 ETGVVLNAPNLPGWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGAN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 234 GLAGEIGHLPLITDGLICRCGNRGCLETVASPVAIARLLSESWG-QTVAPRDLPALIRERNSGALRAVRDAGDAVGRALA 312
Cdd:COG1940   161 GNAGEIGHMPVDPDGPLCGCGNRGCLETYASGPALLRRARELGGaEKLTAEELFAAARAGDPLALEVLDEAARYLGIGLA 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2770181927 313 ALVTLLNPSLVVVGGDLAAAGADILEPMRAGVLRHTLPSAAESVEIVTGGLGDGAEVRGAAGLVL 377
Cdd:COG1940   241 NLINLLDPEVIVLGGGVSAAGDLLLEPIREALAKYALPPAREDPRIVPASLGDDAGLLGAAALAL 305
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 78-379 1.02e-84

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 259.80  E-value: 1.02e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  78 GYAIGADIGHQHVRVILCDLFGEVLWEHWVAKDVDRAPDETLDLVAVLVGRALQETGVGRERVLGIGAGIASPVEIGSGA 157
Cdd:cd24076     1 GAVIGVELGVDYITVVVTDLAGEVLWRREVPLPASDDPDEVLAQLAALIREALAAAPDSPLGILGIGVGVPGLVDSEDGV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 158 LGaegIMP--GWVGLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGARGL 235
Cdd:cd24076    81 VL---LAPnlGWRDVPLRDLLEEALGVPVFVDNEANAAALAEKRFGAGRGVSDLVYLSAGVGIGAGIILDGELYRGASGF 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 236 AGEIGHLPLITDGLICRCGNRGCLETVASPVAIARLLSESwGQTVAPRDLPALI---RERNSGALRAVRDAGDAVGRALA 312
Cdd:cd24076   158 AGEIGHMTVDPDGPPCSCGNRGCWETYASERALLRAAGRL-GAGGEPLSLAELVeaaRAGDPAALAALEEVGEYLGIGLA 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2770181927 313 ALVTLLNPSLVVVGGDLAAAGADILEPMRAGVLRHTLPSAAESVEIVTGGLGDGAEVRGAAGLVLAD 379
Cdd:cd24076   237 NLVNTFNPELVVLGGALAPLGPWLLPPLRAEVARRALPAPARDVRIVVSRLGEDAAALGAAALAIDH 303
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 81-378 4.55e-57

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 188.32  E-value: 4.55e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  81 IGADIGHQHVRVILCDLFGEVLWEHWVAKDVDRAPDETLDLVAVLVGRALQetgVGRERvlgIGAGIASPVEIGSGALGA 160
Cdd:pfam00480   1 IGIDIGGTKIAAALFDEEGEILARERVPTPTTTTEETLVDAIAFFVDSAQR---KFGEL---IAVGIGSPGLISPKYGYI 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 161 EGI-MPGWVGLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGARGLAGEI 239
Cdd:pfam00480  75 TNTpNIGWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGEI 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 240 GHLPLITDGLICRCGNRGCLETVASPVAIARlLSESWGQTVAPRDLPALIRERNSGALRAVRDAGDAVGRALAALVTLLN 319
Cdd:pfam00480 155 GHIQLDPNGPKCGCGNHGCLETIASGRALEK-RYQQKGEDLEGKDIIVLAEQGDEVAEEAVERLARYLAKAIANLINLFD 233

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 320 PSLVVVGGDLAAAGaDILEPMRAGVLRHTLPSAAES-VEIVTGGLGDGAEVRGAAGLVLA 378
Cdd:pfam00480 234 PQAIVLGGGVSNAD-GLLEAIRSLVKKYLNGYLPVPpVIIVAASLGDNAGALGAAALAKQ 292
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 172-327 6.58e-25

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 103.07  E-value: 6.58e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 172 LTDELRRRTSLPVRVTNDANAGALAErmYGAGRQAG-DMVYVRLSAGIGAGIVSNGRLLLGARGLAGEIGHLPLITDGLI 250
Cdd:PRK05082   88 LVQTLEQLTDLPTIALNDAQAAAWAE--YQALPDDIrNMVFITVSTGVGGGIVLNGKLLTGPGGLAGHIGHTLADPHGPV 165

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2770181927 251 CRCGNRGCLETVASPVAIARlLSESWGQTVAPRDLPALIRERNSGALRAVRDAGDAVGRALAALVTLLNPSLVVVGG 327
Cdd:PRK05082  166 CGCGRRGCVEAIASGRAIAA-AAQGWLAGCDAKTIFERAGQGDEQAQALINRSAQAIARLIADLKATLDCQCVVLGG 241
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 9-57 1.33e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 39.49  E-value: 1.33e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2770181927   9 LRVLEALHTSPRSSRPELVRVTGLSRATVSSLIADLITVGLVTEDESPE 57
Cdd:pfam12802   8 FRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPA 56
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
8-55 2.38e-04

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 42.57  E-value: 2.38e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2770181927   8 RLRVLEALHTSPRSsRPELVRVTGLSRATVSSLIADLITVGLVTEDES 55
Cdd:COG4742    18 RKNILLLLAEGPKT-RSELAESLDVSRSTILRQLKELEERGLIERDDG 64
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 8-52 4.22e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 35.74  E-value: 4.22e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2770181927   8 RLRVLEALHTSPRSSRpELVRVTGLSRATVSSLIADLITVGLVTE 52
Cdd:cd00090     9 RLRILRLLLEGPLTVS-ELAERLGLSQSTVSRHLKKLEEAGLVES 52
 
Name Accession Description Interval E-value
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 74-377 1.09e-95

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 287.95  E-value: 1.09e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  74 VPSAGYAIGADIGHQHVRVILCDLFGEVLWEHWVAKDVDRAPDETLDLVAVLVGRALQETGVGRERVLGIGAGIASPVEI 153
Cdd:COG1940     1 NPDAGYVIGIDIGGTKIKAALVDLDGEVLARERIPTPAGAGPEAVLEAIAELIEELLAEAGISRGRILGIGIGVPGPVDP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 154 GSGALGAEGIMPGWVGLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGAR 233
Cdd:COG1940    81 ETGVVLNAPNLPGWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGAN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 234 GLAGEIGHLPLITDGLICRCGNRGCLETVASPVAIARLLSESWG-QTVAPRDLPALIRERNSGALRAVRDAGDAVGRALA 312
Cdd:COG1940   161 GNAGEIGHMPVDPDGPLCGCGNRGCLETYASGPALLRRARELGGaEKLTAEELFAAARAGDPLALEVLDEAARYLGIGLA 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2770181927 313 ALVTLLNPSLVVVGGDLAAAGADILEPMRAGVLRHTLPSAAESVEIVTGGLGDGAEVRGAAGLVL 377
Cdd:COG1940   241 NLINLLDPEVIVLGGGVSAAGDLLLEPIREALAKYALPPAREDPRIVPASLGDDAGLLGAAALAL 305
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 78-379 1.02e-84

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 259.80  E-value: 1.02e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  78 GYAIGADIGHQHVRVILCDLFGEVLWEHWVAKDVDRAPDETLDLVAVLVGRALQETGVGRERVLGIGAGIASPVEIGSGA 157
Cdd:cd24076     1 GAVIGVELGVDYITVVVTDLAGEVLWRREVPLPASDDPDEVLAQLAALIREALAAAPDSPLGILGIGVGVPGLVDSEDGV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 158 LGaegIMP--GWVGLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGARGL 235
Cdd:cd24076    81 VL---LAPnlGWRDVPLRDLLEEALGVPVFVDNEANAAALAEKRFGAGRGVSDLVYLSAGVGIGAGIILDGELYRGASGF 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 236 AGEIGHLPLITDGLICRCGNRGCLETVASPVAIARLLSESwGQTVAPRDLPALI---RERNSGALRAVRDAGDAVGRALA 312
Cdd:cd24076   158 AGEIGHMTVDPDGPPCSCGNRGCWETYASERALLRAAGRL-GAGGEPLSLAELVeaaRAGDPAALAALEEVGEYLGIGLA 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2770181927 313 ALVTLLNPSLVVVGGDLAAAGADILEPMRAGVLRHTLPSAAESVEIVTGGLGDGAEVRGAAGLVLAD 379
Cdd:cd24076   237 NLVNTFNPELVVLGGALAPLGPWLLPPLRAEVARRALPAPARDVRIVVSRLGEDAAALGAAALAIDH 303
ASKHA_NBD_ROK_TM1224-like cd24059
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ...
 79-377 5.52e-73

nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466909 [Multi-domain]  Cd Length: 305  Bit Score: 229.78  E-value: 5.52e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  79 YAIGADIGHQHVRVILCDLFGEVLWEHWVAKDVDRAPDETLDLVAVLVGRALQETGVGReRVLGIGAGIASPVEIGSGAL 158
Cdd:cd24059     2 YVIGVEIGRDLLSAVLCDLSGNILAREKYPLDEKENPEEVLEKLYELIDRLLEKENIKS-KILGIGIGAPGPLDVEKGII 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 159 GAEGIMPGWVGLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGARGLAGE 238
Cdd:cd24059    81 LNPPNFPGWENIPLVELLEEKFGIPVYLDNDANAAALAEKWYGKGKNYDNFIYILADEGIGAGIIINGKLYRGVDGYAGE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 239 IGHLPLITDGLICRCGNRGCLETVASPVAIARLLSESWGQtvaPRDLPALIRER----NSGALRAVRDAGDAVGRALAAL 314
Cdd:cd24059   161 IGHTSIDINGPRCSCGNRGCLELYASIPAIEKKARSALGS---GRSFQLDIVEAlqkgDPIADEVIEEAAKYLGIGLVNL 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2770181927 315 VTLLNPSLVVVGGDLAAAGADILEPMRAGVLRHTLPSAAESVEIVTGGLGDGAEVRGAAGLVL 377
Cdd:cd24059   238 INLLNPEAIIIGGELIYLGERYLEPIEKEVNSRLFGRNAREVRILKSSLGEDAPLLGAAALVL 300
ASKHA_ATPase_ROK_CYANR cd24073
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ...
 78-378 1.37e-65

ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466923 [Multi-domain]  Cd Length: 304  Bit Score: 210.87  E-value: 1.37e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  78 GYAIGADIGHQHVRVILCDLFGEVLWEHWVAKDvDRAPDETLDLVAVLVGRALQETGVGRERVLGIGAGIASPVEIGSGA 157
Cdd:cd24073     1 AYVVGVKLTEDRITAVLTDLRGNVLASHTLPLD-SGDPEAVAEAIAEAVAELLAQAGLSPDRLLGIGVGLPGLVDAETGI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 158 LGAEGIMpGWVGLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGARGLAG 237
Cdd:cd24073    80 CRWSPLL-GWRDVPLAELLEERLGLPVYVENDVNALALAEHWFGAGRGLDNFAVVTIGRGIGCGLVVDGRLYRGAHGGAG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 238 EIGHLPLITDGLICRCGNRGCLETVASPVAIARLLSESWGQTVAPR--DLPALIRERNSGALRAVRDAGDAVGRALAALV 315
Cdd:cd24073   159 EIGHTTVDPDGPPCRCGKRGCLEAYASDPAILRQAREAGLRGEPLTieDLLAAARAGDPAARAILRRAGRALGLALANLV 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2770181927 316 TLLNPSLVVVGGDLAAAGADILEPMRAGVLRHTLPSAAESVEIVTGGLGDGAEVRGAAGLVLA 378
Cdd:cd24073   239 NLLDPELIIISGEGVRAGDLLFEPMREALRAHVFPGLASDLELVIHPWGDEAWARGAAALALQ 301
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 81-375 8.91e-64

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 203.85  E-value: 8.91e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  81 IGADIGHQHVRVILCDLFGEVLWEHWVAKDVDRAPDETLDLVAVLVGRALQETGVgRERVLGIGAGIASPVEIGSGALGA 160
Cdd:cd23763     1 IGIDIGGTKIRAALVDLDGEILARERVPTPAEEGPEAVLDRIAELIEELLAEAGV-RERILGIGIGVPGPVDPETGIVLF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 161 EGIMPGWVGLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGARGLAGEIG 240
Cdd:cd23763    80 APNLPWWKNVPLRELLEERLGLPVVVENDANAAALGEAWFGAGRGVRNFVYITLGTGIGGGIIIDGKLYRGANGAAGEIG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 241 HLPLitdglicrcgnrgcletvaspvaiarllseswgqtvaprdlpalirernsgalraVRDAGDAVGRALAALVTLLNP 320
Cdd:cd23763   160 HITV-------------------------------------------------------LEEAARYLGIGLANLINLLNP 184

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2770181927 321 SLVVVGGDLAAAGADILEPMRAGVLRHTLPSAAESVEIVTGGLGDGAEVRGAAGL 375
Cdd:cd23763   185 ELIVLGGGVAEAGDLLLEPIREAVRRRALPPLRRRVRIVPSELGDDAGLLGAAAL 239
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 81-378 4.55e-57

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 188.32  E-value: 4.55e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  81 IGADIGHQHVRVILCDLFGEVLWEHWVAKDVDRAPDETLDLVAVLVGRALQetgVGRERvlgIGAGIASPVEIGSGALGA 160
Cdd:pfam00480   1 IGIDIGGTKIAAALFDEEGEILARERVPTPTTTTEETLVDAIAFFVDSAQR---KFGEL---IAVGIGSPGLISPKYGYI 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 161 EGI-MPGWVGLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGARGLAGEI 239
Cdd:pfam00480  75 TNTpNIGWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGEI 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 240 GHLPLITDGLICRCGNRGCLETVASPVAIARlLSESWGQTVAPRDLPALIRERNSGALRAVRDAGDAVGRALAALVTLLN 319
Cdd:pfam00480 155 GHIQLDPNGPKCGCGNHGCLETIASGRALEK-RYQQKGEDLEGKDIIVLAEQGDEVAEEAVERLARYLAKAIANLINLFD 233

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 320 PSLVVVGGDLAAAGaDILEPMRAGVLRHTLPSAAES-VEIVTGGLGDGAEVRGAAGLVLA 378
Cdd:pfam00480 234 PQAIVLGGGVSNAD-GLLEAIRSLVKKYLNGYLPVPpVIIVAASLGDNAGALGAAALAKQ 292
ASKHA_NBD_ROK_FnNanK-like cd24068
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ...
 79-373 1.43e-55

nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466918 [Multi-domain]  Cd Length: 294  Bit Score: 184.30  E-value: 1.43e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  79 YAIGADIGHQHVRVILCDLFGEVLWEHWVAKDVDRAPDETLDLVAVLVgRALQEtgvgRERVLGIGAGIASPVEIGSGA- 157
Cdd:cd24068     1 KILGIDIGGTKIKYGLVDADGEILEKDSVPTPASKGGDAILERLLEII-AELKE----KYDIEGIGISSAGQVDPKTGEv 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 158 LGAEGIMPGWVGLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGARGLAG 237
Cdd:cd24068    76 IYATDNLPGWTGTNLKEELEERFGLPVAVENDVNCAALAEKWLGAAKGLDDFLCLTLGTGIGGAIILDGRLYRGANGSAG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 238 EIGHLPLITDGLICRCGNRGCLETVASPVAIARLLSESWGQTVA-PRDLPALIRERNSGALRAVRDAGDAVGRALAALVT 316
Cdd:cd24068   156 ELGHMVVDPGGRPCCCGGKGCLEQYASGTALVRRVAEALGEPGIdGREIFDLADAGDPLAKEVVEEFAEDLATGLANLVH 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2770181927 317 LLNPSLVVVGGDLAAAGADILEPMRAGVLRHTLPSAAESVEIVTGGLGDGAEVRGAA 373
Cdd:cd24068   236 IFDPEVIVIGGGISAQGELFLEELREELRKLLMPPLLDATKIEPAKLGNDAGLLGAA 292
ASKHA_NBD_ROK_BsGLK-like cd24062
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ...
 79-375 4.51e-54

nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466912 [Multi-domain]  Cd Length: 311  Bit Score: 180.95  E-value: 4.51e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  79 YAIGADIGHQHVRVILCDLFGEVLWEHWVAKDVDRAPDETLDLVAVLVGRALQETGVGRERVLGIGAGIASPVEIGSGAL 158
Cdd:cd24062     1 WIVGIDVGGTTIKMAFLTQEGEIVQKWEIPTNKLEGGENIITDIAESIQQLLEELGYSKEDLIGIGVGVPGPVDVETGTV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 159 gAEGIMPGWVGLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGARGLAGE 238
Cdd:cd24062    81 -EVAVNLGWKNFPLKDKLEALTGIPVVIDNDANAAALGEMWKGAGQGAKDLVFITLGTGVGGGVIANGKIVHGANGAAGE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 239 IGHLPLITDGLI-CRCGNRGCLETVASPVAIARL----LSES----------WGQTVAPRDLPALIRERNSGALRAVRDA 303
Cdd:cd24062   160 IGHITVNPEGGApCNCGKTGCLETVASATGIVRIareeLEEGkgssalrilaLGGELTAKDVFEAAKAGDELALAVVDTV 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2770181927 304 GDAVGRALAALVTLLNPSLVVVGGDLAAAGADILEPMRAGVLRHTLPSAAESVEIVTGGLGDGAEVRGAAGL 375
Cdd:cd24062   240 ARYLGLALANLANTLNPEKIVIGGGVSAAGEFLLSPVKEYFDRFTFPRVRQDTEIVLATLGNDAGVIGAAWL 311
ASKHA_NBD_ROK_ApGLK-like cd24063
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ...
 79-375 4.56e-50

nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466913 [Multi-domain]  Cd Length: 308  Bit Score: 170.60  E-value: 4.56e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  79 YAIGADIGHQHVRVILCDLFGEVLWEHWVAKDVDRAPDETLDLVAVLVGRALQETGvgRERVLGIGAGIASPVEIGSGAL 158
Cdd:cd24063     1 YYVAVDIGGTWIRAGLVDEDGRILLKIRQPTPKTGDPGTVSEQVLGLIETLLSKAG--KDSIEGIGVSSAGPLDLRKGTI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 159 GAEGIMPGWVgLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGARGLAGE 238
Cdd:cd24063    79 VNSPNIKGKE-IPLVEPLKEEFNIPVALLNDAVAAALGEHLFGAGRGTSNLVYITISTGIGGGVIVDGRLLLGKNGNAAE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 239 IGHLPL-ITDGLICRCGNRGCLETVASPVAIARLLSE---------------SWGQTVAPRDLPALIRERNSGALRAVRD 302
Cdd:cd24063   158 VGHLVVdTESGLKCGCGGYGHWEAFASGRGIPRFAREwaegfssrtslklrnPGGEGITAKEVFSAARKGDPLALKIIEK 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2770181927 303 AGDAVGRALAALVTLLNPSLVVVGGDLAAAGADILEPMRAGVLRHTLPSAAesVEIVTGGLGDGAEVRGAAGL 375
Cdd:cd24063   238 LARYNGRGIANVINAYDPELIVIGGSVFNNNKDILDPLIEYLEKNPAISKG--PEIVLSELGDDVGLIGALAL 308
ASKHA_NBD_ROK_TtHK-like cd24065
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ...
 115-373 1.47e-49

nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466915 [Multi-domain]  Cd Length: 289  Bit Score: 168.66  E-value: 1.47e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 115 PDETLDLVAVLVGRALQETGVGRERVLGIGAGIASPVEIGSGALGAEGIMPGWVGLRLTDELRRRTSLPVRVTNDANAGA 194
Cdd:cd24065    31 PREGGEAVLDALARAVEALQAEAPGVEAVGLGVPGPLDFRRGRVRFAPNIPGLTDFPIRRGLAERLGLPVVLENDANAAA 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 195 LAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGARGLAGEIGHLPLITDGLICRCGNRGCLETVASPVAIARLLSE 274
Cdd:cd24065   111 LAEHHYGAARGTESSVYVTISTGIGGGLVLGGRVLRGRHGQAGEIGHTTVLPGGPMCGCGLVGCLEALASGRALARDASF 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 275 SWGQTVAPRDLPALIRERNSGALRAVRDAGDAVGRALAALVTLLNPSLVVVGGDLAAAGADILEPMRAGVLRHTlpSAAE 354
Cdd:cd24065   191 AYGRPMSTAELFELAQQGEPKALRIVEQAAAHLGIGLANLQKALDPEVFVLGGGVAQVGDYYLLPVQEAARRYT--EGWH 268

                         250
                  ....*....|....*....
gi 2770181927 355 SVEIVTGGLGDGAEVRGAA 373
Cdd:cd24065   269 APPLRLAHLGTDAGVIGAA 287
ASKHA_NBD_ROK_SgGLK-like cd24061
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ...
 80-377 1.24e-47

nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466911 [Multi-domain]  Cd Length: 306  Bit Score: 164.06  E-value: 1.24e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  80 AIGADIGHQHVRVILCDLFGEVLWEHWVAKDVDraPDETLDLVAVLVGRAlqetgVGRERVLGIGAGIASPVE-IGSGAL 158
Cdd:cd24061     1 TIGVDIGGTKIAAGVVDEEGEILATERVPTPPT--ADGIVDAIVEAVEEL-----REGHDVSAVGVAAAGFVDaDRATVL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 159 GAEGImpGWVGLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGARGLAGE 238
Cdd:cd24061    74 FAPNI--AWRNEPLKDLLEARIGLPVVIENDANAAAWAEYRFGAGRGTDDMVMITVGTGLGGGIVIGGKLLRGAFGIAGE 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 239 IGHLPLITDGLICRCGNRGCLETVASPVAIAR---------------LLSESWGQTVAPRDLPALIRERNSGALRAVRDA 303
Cdd:cd24061   152 FGHIRVVPDGLLCGCGSRGCWEQYASGRALVRyakeaanatpegaavLLADGSVDGITGKHISEAARAGDPVALDALREL 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2770181927 304 GDAVGRALAALVTLLNPSLVVVGGDLAAAGADILEPMRAGVLRHTLPSAAESV-EIVTGGLGDGAEVRGAAGLVL 377
Cdd:cd24061   232 ARWLGAGLASLAALLDPELFVIGGGVSDAGDLLLDPIREAFERWLPGRGWRPIpRLRTAQLGNDAGLIGAADLAR 306
ASKHA_ATPase_ROK_Lmo0178-like cd24071
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ...
 78-377 6.78e-47

ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466921 [Multi-domain]  Cd Length: 312  Bit Score: 162.45  E-value: 6.78e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  78 GYAIGADIGHQHVRVILCDLFGEVLWEHWVAKDVDRAPDETLDLVAVLVGRALQETGVgRERVLGIGAGIASPVEIGSGA 157
Cdd:cd24071     1 GYIIGVKIEEGYLVLALTDLKGKILEKTRIPFDHETDPEKVIELIAENIKKLIKNKHV-EKKLLGIGIAVSGLVDSKKGI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 158 LGAEGIMpGWVGLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGARGLAG 237
Cdd:cd24071    80 VIRSTIL-GWENVELKKILKEKFKIPVFIDNDVNSFALAELWKGKGKGYSNFICVTVGAGIGSSLVIDGKLYTGNFGGAG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 238 EIGHLPLITDGLICRCGNRGCLETVASPVAIARLLSESWGQTVAPRDL------PALIR----ERNSGALRAVRDAGDAV 307
Cdd:cd24071   159 EIGHMTIQPDGRKCYCGQKGCLEAYASFEALVNEIKELTESYPLSLLKeledfeIEKVReaaeEGDSVATELFKKAGEYL 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 308 GRALAALVTLLNPSLVVVGGDLAAAGADILEPMRAGVLRHTLPSAAESVEIVTGGLGDGAEVRGAAGLVL 377
Cdd:cd24071   239 GIGIKNLINIFNPEAIIIGGEGLEFKDYFLPKIIEIAKENFFGKAGRNVIILVDSLGEDAWVLGAALLVI 308
ASKHA_NBD_ROK_TmGLK-like cd24064
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ...
 80-373 1.90e-42

nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466914 [Multi-domain]  Cd Length: 301  Bit Score: 150.34  E-value: 1.90e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  80 AIGADIGHQHVRVILCDLFGEVLWEHWVAKDVDRAPDETLDLVAVLVGRALQETGVgrervLGIGAGIASPVEIGSGALG 159
Cdd:cd24064     1 VIGIDLGGTDTKIGIVDENGDILKKKTIDTKVENGKEDVINRIAETVNELIEEMEL-----LGIGIGSPGSIDRENGIVR 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 160 AEGIMPGWVGLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGARGLAGEI 239
Cdd:cd24064    76 FSPNFPDWRNFPLVPLIEERTGIKVFLENDANAFALGEWWFGNAKGSNHIIGLTLGTGVGSGVICHGQLLTGYDGIAAEL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 240 GHLPLITDGLICRCGNRGCLETVASPVAIARLLSESWGQTvaPRDLPALIRERNSG------------ALRAVRDAGDAV 307
Cdd:cd24064   156 GHVIVEPNGPICGCGNRGCVEAFASATAIIRYARESRKRY--PDSLAGESEKINAKhvfdaarkndplATMVFRRVVDAL 233

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2770181927 308 GRALAALVTLLNPSLVVVGGDLAAAGADILEPMRAGVLRHTLPSAAESVEIVTGGLGDGAEVRGAA 373
Cdd:cd24064   234 AIAIGGFVHIFNPEIIIIGGGISRAGSFLLDPIREKTKKYVMLSFQDTYSIELSNLVEDAGILGAA 299
ASKHA_ATPase_ROK_SaXylR-like cd24077
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ...
 78-377 6.13e-39

ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466927 [Multi-domain]  Cd Length: 295  Bit Score: 140.75  E-value: 6.13e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  78 GYAIGADIGHQHVRVILCDLFGEVLWEHWVaKDVDRAPDETLDLVAVLVGRALQETGVGRERVLGIGAGIaspveigSGA 157
Cdd:cd24077     1 GYSIGIDLGYNYISLMLTYLDGEIISSKQI-KLLDISFENILEILKSIIQELISQAPKTPYGLVGIGIGI-------HGI 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 158 LGAEGIM--PG--WVGLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQagDMVYVRLSAGIGAGIVSNGRLLLGAR 233
Cdd:cd24077    73 VDENEIIftPYydLEDIDLKEKLEEKFNVPVYLENEANLSALAERTFSEDYD--NLISISIHSGIGAGIIINNQLYRGYN 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 234 GLAGEIGHLPLITDGLICRCGNRGCLETVASPVAIARLLSESWG-QTVAPRDLPALIRERNSGALRAVRDAGDAVGRALA 312
Cdd:cd24077   151 GFAGEIGHMIIVPNGKPCPCGNKGCLEQYASEKALLKELSEKKGlETLTFDDLIQLYNEGDPEALELIDQFIKYLAIGIN 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2770181927 313 ALVTLLNPSLVVVGGDLAAAGADILEpmragVLRHTLPS-AAESVEIVTGGLGDGAEVRGAAGLVL 377
Cdd:cd24077   231 NIINTFNPEIIIINSSLINEIPELLE-----KIKEQLSSsFNKYVEILISTLGKNATLLGGAAVAI 291
ASKHA_ATPase_ROK_NagC cd24075
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ...
 79-376 5.99e-38

ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466925 [Multi-domain]  Cd Length: 315  Bit Score: 138.65  E-value: 5.99e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  79 YAIGADIGHQHVRVILCDLFGEVLWEHWV---AKDVDRAPDETLDLVAVLVGRALQETgvgrERVLGIG---AGIASPVE 152
Cdd:cd24075     2 HILAVRLGRHDLTLGLYDLSGELLAEHTVpltALNQEALLSQLIEEIAQFLKSHRRKT----QRLIAISitlPGLINPKT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 153 igsgalgaeGIMP--------GWvglRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVS 224
Cdd:cd24075    78 ---------GVVHymphiqvkSW---PIVEELEQRFNVPCFIGNDIRSLALAEHYFGASKDCKDSILVRIHHGIGAGIII 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 225 NGRLLLGARGLAGEIGHLPLITDGLICRCGNRGCLETVASPVAI---ARLLSESWGQTVAPRDLP---ALIRERNSG--- 295
Cdd:cd24075   146 DGKLFLGQNGNAGEIGHIQIEPLGERCHCGNFGCLETVASNAAIeqrVKKLLKQGYASQLTLQDCtikDICQAALNGdql 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 296 ALRAVRDAGDAVGRALAALVTLLNPSLVVVGGDLAAAGADILEPMRAGVLRHTLPSAAESVEIVTGGLgDGAEVRGAAGL 375
Cdd:cd24075   226 AQDVIKRAGRYLGKVIAILINLLNPQKIIIAGEITQADKVLLPVIKKCIQSQALPDFRQELKIVASQL-DHNSAIGAFAL 304


                  .
gi 2770181927 376 V 376
Cdd:cd24075   305 V 305
ASKHA_NBD_ROK_GNE cd24060
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ...
 80-375 6.72e-37

nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.


Pssm-ID: 466910 [Multi-domain]  Cd Length: 305  Bit Score: 135.62  E-value: 6.72e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  80 AIGADIGHQHVRVILCDLFGEVLweHWVAKDVDRAPDETLDLVAVLVGRALQETGVGRERVLGIGAGIASPVEIGSG-AL 158
Cdd:cd24060     2 ALAVDLGGTNLRVAIVSMKGEIV--KKYTQPNPKTYEERIDLILQMCVEAASEAVKLNCRILGVGISTGGRVNPREGiVL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 159 GAEGIMPGWVGLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGARGLAGE 238
Cdd:cd24060    80 HSTKLIQEWSSVDLRTPISDALHLPVWVDNDGNCAALAERKFGHGKGVENFVTVITGTGIGGGIILNHELIHGSSFCAAE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 239 IGHLPLITDGLICRCGNRGCLETVASPVAIARLLSESW--------------GQTVAPRDLPALIRERNSGALRAVRDAG 304
Cdd:cd24060   160 LGHIVVSLDGPDCMCGSHGCVEAYASGMALQREAKKLHdedlllvegmsvtnDEEVTAKHLIQAAKLGNAKAQKILRTAG 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2770181927 305 DAVGRALAALVTLLNPSLVVVGGDLAAAGADILEPMragVLRHTLPSAAEsVEIVTGGLGDGAeVRGAAGL 375
Cdd:cd24060   240 TALGLGIVNILHTLNPSLVILSGVLASHYENIVKDV---IAQRALPSVQN-VDVVVSDLVDPA-LLGAASM 305
ASKHA_ATPase_ROK_YphH-like cd24072
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ...
 90-339 6.36e-36

ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466922 [Multi-domain]  Cd Length: 308  Bit Score: 133.31  E-value: 6.36e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  90 VRVILCDLFGEVLWEHWVAKDVDRAPDETLDLVAVLVGRALQETgvgRERVLGIG---AGIASPVEigsgalGAEGIMPG 166
Cdd:cd24072    13 LRAQVGNACGELLGEFEYRVITLETPEALIDEIIDCIDRLLKLW---KDRVKGIAlaiQGLVDSHK------GVSLWSPG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 167 --WVGLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGARGLAGEIGHLPL 244
Cdd:cd24072    84 apWRNIEIKYLLEERYGIPVFVENDCNMLALAEKWQGELRQSRDFCVINLDYGIGSAIVIDNKLYIGASSGSGEIGHTKV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 245 ITDGLICRCGNRGCLETVASPVAI---ARLLSESWGQTVAPRD-----LPALIRERNSGALRAVRDAGDAVGRALAALVT 316
Cdd:cd24072   164 NPDGARCDCGRRGCLETVASNSALkrnARVTLKLGPVSADPEKltmeqLIEALEEGEPIATQIFDRAANAIGRSLANILN 243

                         250       260
                  ....*....|....*....|...
gi 2770181927 317 LLNPSLVVVGGDLAAAGaDILEP 339
Cdd:cd24072   244 LLNPEQVLLYGRGCRAG-DLLLP 265
ASKHA_NBD_ROK_EcNanK-like cd24069
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ...
 146-327 4.35e-35

nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466919 [Multi-domain]  Cd Length: 283  Bit Score: 130.48  E-value: 4.35e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 146 GIASPVEIGSGALGA--EGIMPGWVGLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIV 223
Cdd:cd24069    56 AVASTGIIRDGVLTAlnPKNLGGLSGFPLADALQQLLGVPVVLLNDAQAAAWGEYQAGDGEGVGNLVFITVSTGVGGGLV 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 224 SNGRLLLGARGLAGEIGHLPLITDGLICRCGNRGCLETVASPVAIARLLSESWGQTVAPRDLPALIRERNSGALRAVRDA 303
Cdd:cd24069   136 LNGQLLTGPNGLAGHIGHTLADPPGPVCGCGRRGCVEAIASGTAIAAAASEILGEPVDAKDVFERARSGDEEAARLIDRA 215

                         170       180
                  ....*....|....*....|....
gi 2770181927 304 GDAVGRALAALVTLLNPSLVVVGG 327
Cdd:cd24069   216 ARALADLIADLKATLDLDCVVIGG 239
ASKHA_ATPase_ROK_Mlc cd24074
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ...
 85-359 1.47e-34

ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466924 [Multi-domain]  Cd Length: 322  Bit Score: 129.74  E-value: 1.47e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  85 IGHQHVRVILCDLFGEVLWEHWVAKDVDrAPDETLDLVAVLVGRALQETGVGRERVLGIGagIASPVEIGSgalgAEGI- 163
Cdd:cd24074     9 IGRGYITLALRDLNGRLLAEERYPLPAK-DNDPFLDRLLESISEFFSRHQKKLERLTAIA--ITLPGIIDP----ESGIv 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 164 --MPGW--VGLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGARGLAGEI 239
Cdd:cd24074    82 hrLPFYdiKNLPLGEALEQHTGLPVYVQHDISAWTLAERFFGAAKGAKNIIQIVIDDDIGAGVITDGQLLHAGSSRLGEL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 240 GHLPLITDGLICRCGNRGCLETVASPVAIARLLSES---------WGQTVAPRDLPALIRERNSGALRAVRDAGDAVGRA 310
Cdd:cd24074   162 GHTQIDPYGKRCYCGNHGCLETVASIPAILEQANQLleqspdsmlHGQPISIESLCQAALAGDPLAQDIIIQVGRHLGRI 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2770181927 311 LAALVTLLNPSLVVVGGDLAAAgADILEPM-RAGVLRHTLPSAAESVEIV 359
Cdd:cd24074   242 LAILVNLFNPEKILIGSPLNNA-AEILFPAlSQSIRQQSLPAYSQHLQIE 290
ASKHA_NBD_ROK_NAGK cd24057
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ...
 80-373 2.13e-34

nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466907 [Multi-domain]  Cd Length: 298  Bit Score: 128.89  E-value: 2.13e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  80 AIGADIGHQHVRVILCDLFGEVLWEHWVAKDVDrAPDETLDLVAVLVGRALQETGVgRERVlgiGAGIASPVEIGSGALG 159
Cdd:cd24057     2 YYGFDIGGTKIEFAVFDEALQLVWTKRVPTPTD-DYAAFLAAIAELVAEADARFGV-KGPV---GIGIPGVIDPEDGTLI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 160 AEGImPGWVGLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGARGLAGEI 239
Cdd:cd24057    77 TANI-PAAKGRPLRADLSARLGRPVRIDNDANCFALSEAWDGAGRGYPSVFGLILGTGVGGGLVVNGRLVGGRSGIAGEW 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 240 GHLPLITDGLI---------CRCGNRGCLETVASPVAIARLLSESWGQTVAPRDLPALIRERNSGALRAVRDAGDAVGRA 310
Cdd:cd24057   156 GHGPLPADALLlgydlpvlrCGCGQTGCLETYLSGRGLERLYAHLYGEELDAPEIIAAWAAGDPQAVAHVDRWLDLLAGC 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2770181927 311 LAALVTLLNPSLVVVGGDLAAAGAdILEPMRAGVLRHTLPSAAESvEIVTGGLGDGAEVRGAA 373
Cdd:cd24057   236 LANILTALDPDVVVLGGGLSNFPA-LIAELPAALPAHLLSGARTP-RIVPARHGDAGGVRGAA 296
ASKHA_NBD_ROK_EcFRK-like cd24066
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ...
 81-375 6.01e-34

nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466916 [Multi-domain]  Cd Length: 294  Bit Score: 127.71  E-value: 6.01e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  81 IGADIGHQHVRVILCDLFGEVLWEHWVAKDVDrAPDETLDLVAVLVGRALQETGvgRERVLGIGA-GIASPveigsgalg 159
Cdd:cd24066     2 IGIDLGGTKIEGIALDRAGRELLRRRVPTPRG-DYEATLDAIADLVEEAEEELG--APATVGIGTpGSISP--------- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 160 AEGIMPG----WV-GLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGARG 234
Cdd:cd24066    70 RTGLVKNanstWLnGKPLKADLEARLGRPVRIENDANCFALSEATDGAGAGAGVVFGVILGTGVGGGIVVNGRVLTGANG 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 235 LAGEIGHLPLI------TDGLICRCGNRGCLETVASPVAIARLLSESWGQTVAPRDLPALIRERNSGALRAVRDAGDAVG 308
Cdd:cd24066   150 IAGEWGHNPLPwpdedeLPGPPCYCGKRGCVETFLSGPALERDYARLTGKTLSAEEIVALARAGDAAAVATLDRFLDRLG 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2770181927 309 RALAALVTLLNPSLVVVGGDLAAAgADILEPMRAGVLRHTLPSAAESvEIVTGGLGDGAEVRGAAGL 375
Cdd:cd24066   230 RALANVINILDPDVIVLGGGLSNI-DELYTEGPAALARYVFSDEVET-PIVKNKHGDSSGVRGAAWL 294
ASKHA_NBD_ROK_AlsK cd24070
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ...
 79-373 6.99e-29

nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466920 [Multi-domain]  Cd Length: 293  Bit Score: 113.80  E-value: 6.99e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  79 YAIGADIGHQHVRVILCDLFGEVLWEHWV-AKDVDRAPDeTLDLVAVLVGRALQETGVgreRVLGIGAGIASPVEIGSGA 157
Cdd:cd24070     2 YVLGIDIGGTNIRIGLVDEDGKLLDFEKVpSKDLLRAGD-PVEVLADLIREYIEEAGL---KPAAIVIGVPGTVDKDRRT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 158 LGAEGIMPGWVGLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGARGLAG 237
Cdd:cd24070    78 VISTPNIPGLDGVNLADILENKLGIPVILERDVNLLLLYDMRAGNLDDEGVVLGFYIGTGIGNAILINGKPLRGKNGVAG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 238 EIGHLPLITDGLICRCGNRGCLETVASPVAIARLLSESwGQTVAPRDLPAlirerNSGALRAVRDAGDAVGRALAALVTL 317
Cdd:cd24070   158 ELGHIPVYGNGKPCGCGNTGCLETYASGRALEEIAEEH-YPDTPILDIFV-----DHGDEPELDEFVEDLALAIATEINI 231

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2770181927 318 LNPSLVVVGGDLAAAGA---DILEPMRAGVLRHTLPsaAESVEIVTGGLGDGAEVRGAA 373
Cdd:cd24070   232 LDPDAVILGGGVIDMKGfprETLEEYIRKHLRKPYP--ADNLKIIYAELGPEAGVIGAA 288
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 172-327 6.58e-25

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 103.07  E-value: 6.58e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 172 LTDELRRRTSLPVRVTNDANAGALAErmYGAGRQAG-DMVYVRLSAGIGAGIVSNGRLLLGARGLAGEIGHLPLITDGLI 250
Cdd:PRK05082   88 LVQTLEQLTDLPTIALNDAQAAAWAE--YQALPDDIrNMVFITVSTGVGGGIVLNGKLLTGPGGLAGHIGHTLADPHGPV 165

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2770181927 251 CRCGNRGCLETVASPVAIARlLSESWGQTVAPRDLPALIRERNSGALRAVRDAGDAVGRALAALVTLLNPSLVVVGG 327
Cdd:PRK05082  166 CGCGRRGCVEAIASGRAIAA-AAQGWLAGCDAKTIFERAGQGDEQAQALINRSAQAIARLIADLKATLDCQCVVLGG 241
PRK09557 PRK09557
fructokinase; Reviewed
 81-375 9.80e-24

fructokinase; Reviewed


Pssm-ID: 236565 [Multi-domain]  Cd Length: 301  Bit Score: 99.71  E-value: 9.80e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  81 IGADIGHQHVRVILCDLFGEVLWEHWVAKDVDRAPDeTLDLVAVLVGRAlqETGVGRERVLGIG-AGIASPVeigSGAL- 158
Cdd:PRK09557    3 IGIDLGGTKIEVIALDDAGEELFRKRLPTPRDDYQQ-TIEAIATLVDMA--EQATGQRGTVGVGiPGSISPY---TGLVk 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 159 GAEGImpgWV-GLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGARGLAG 237
Cdd:PRK09557   77 NANST---WLnGQPLDKDLSARLNREVRLANDANCLAVSEAVDGAAAGKQTVFAVIIGTGCGAGVAINGRVHIGGNGIAG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 238 EIGHLPL---------ITDGLICRCGNRGCLETVASPVAIARLLSESWGQTVAPRDLPALIRERNSGALRAVRDAGDAVG 308
Cdd:PRK09557  154 EWGHNPLpwmdedelrYRNEVPCYCGKQGCIETFISGTGFATDYRRLSGKALKGSEIIRLVEEGDPVAELAFRRYEDRLA 233

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2770181927 309 RALAALVTLLNPSLVVVGGDLaaAGADILEPMRAGVLRHTLPSAAESVEIVTGGLGDGAEVRGAAGL 375
Cdd:PRK09557  234 KSLAHVINILDPDVIVLGGGM--SNVDRLYPTLPALLKQYVFGGECETPVRKALHGDSSGVRGAAWL 298
PRK13310 PRK13310
N-acetyl-D-glucosamine kinase; Provisional
 116-379 1.49e-21

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 183967 [Multi-domain]  Cd Length: 303  Bit Score: 93.90  E-value: 1.49e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 116 DETLDLVAVLVGRALQETGVGRErvlgIGAGIASPVEIGSGALGAEGImPGWVGLRLTDELRRRTSLPVRVTNDANAGAL 195
Cdd:PRK13310   37 DAFLDAVCELVAEADQRFGCKGS----VGIGIPGMPETEDGTLYAANV-PAASGKPLRADLSARLGRDVRLDNDANCFAL 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 196 AERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGARGLAGEIGHLPLITDGLI----------CRCGNRGCLETVASP 265
Cdd:PRK13310  112 SEAWDDEFTQYPLVMGLILGTGVGGGLVFNGKPISGRSYITGEFGHMRLPVDALTllgwdaplrrCGCGQKGCIENYLSG 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 266 VAIARLLSESWGQTVAPRDLPALIRERNSGALRAVRDAGDAVGRALAALVTLLNPSLVVVGGDLAAAGAdILEPMRAGVL 345
Cdd:PRK13310  192 RGFEWLYQHYYGEPLQAPEIIALYYQGDEQAVAHVERYLDLLAICLGNILTIVDPHLVVLGGGLSNFDA-IYEQLPKRLP 270

                         250       260       270
                  ....*....|....*....|....*....|....
gi 2770181927 346 RHTLPSAAESVeIVTGGLGDGAEVRGAAGLVLAD 379
Cdd:PRK13310  271 RHLLPVARVPR-IEKARHGDAGGVRGAAFLHLTD 303
ASKHA_NBD_ROK_BsFRK-like cd24067
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ...
 115-375 6.61e-19

nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466917 [Multi-domain]  Cd Length: 285  Bit Score: 86.06  E-value: 6.61e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 115 PDETLDLVAvlvgRALQETgvgRERVLGIGagIAS--PVEI--GSGALGaeGIM----PGWVGLRLTDELRRRTSLPVRV 186
Cdd:cd24067    33 PEETLQAVI----DFFREQ---EEPIDAIG--IASfgPIDLnpTSPTYG--YITttpkPGWRNFDILGALKRAFPVPVGF 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 187 TNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGArgLAGEIGHLPLITD------GLICRCGNrGCLE 260
Cdd:cd24067   102 DTDVNAAALAEYRWGAAKGLDSLAYITVGTGIGVGLVVNGKPVHGL--LHPEMGHIRVPRHpdddgfPGVCPFHG-DCLE 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 261 TVASPVAIArllsESWGqtVAPRDLPAlirernsgALRAVRDAGDAVGRALAALVTLLNPSLVVVGGDLaAAGADILEPM 340
Cdd:cd24067   179 GLASGPAIA----ARWG--IPAEELPD--------DHPAWDLEAYYLAQACANLTLTLSPERIVLGGGV-MQRPGLFPRI 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2770181927 341 RAGVLR-----HTLPSAAESVE--IVTGGLGDGAEVRGAAGL 375
Cdd:cd24067   244 REKFRKllngyLEVPRLLPDIDeyIVPPALGNDAGILGALAL 285
PRK09698 PRK09698
D-allose kinase; Provisional
 79-373 1.44e-16

D-allose kinase; Provisional


Pssm-ID: 182034 [Multi-domain]  Cd Length: 302  Bit Score: 79.64  E-value: 1.44e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  79 YAIGADIGHQHVRVILCDLFGEVLWEHWVAKDVDRAPDETLDLVAVLVGRALQEtgvgRERVLGIGAGIASPVEIGSGAL 158
Cdd:PRK09698    5 VVLGIDMGGTHIRFCLVDAEGEILHCEKKRTAEVIAPDLVSGLGEMIDEYLRRF----NARCHGIVMGFPALVSKDRRTV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 159 GAEGIMPGWVG--LRLTDELRRRTSLPVRVTNDANAGALAERMygAGRQAGDMVY-VRLSAGIGAGIVSNGRLLLGARGL 235
Cdd:PRK09698   81 ISTPNLPLTALdlYDLADKLENTLNCPVFFSRDVNLQLLWDVK--ENNLTQQLVLgAYLGTGMGFAVWMNGAPWTGAHGV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 236 AGEIGHLPLITDGLICRCGNRGCLETVASPVAIARLLSESwgqtvaPRDLP---ALIRERNSgalRAVRDAGDAVGRALA 312
Cdd:PRK09698  159 AGELGHIPLGDMTQHCGCGNPGCLETNCSGMALRRWYEQQ------PRDYPlsdLFVHAGDH---PFIQSLLENLARAIA 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2770181927 313 ALVTLLNPSLVVVGGDLAAAGADILEPMRAGVLRHTL-PSAAESVEIVTGGLGDGAEVRGAA 373
Cdd:PRK09698  230 TSINLFDPDAIILGGGVMDMPAFPRETLIAMIQKYLRkPLPYEVVRFIYASSSDFNGAQGAA 291
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 84-327 1.32e-14

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 73.37  E-value: 1.32e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  84 DIGHQHVRVILCDLFGEVLwehwvAKDVDRAPDETLD-LVAVLVGRALQEtgvgRERVLGIG---AGIASPVE---IGSG 156
Cdd:cd24152     6 DIGGTFIKYALVDENGNII-----KKGKIPTPKDSLEeFLDYIKKIIKRY----DEEIDGIAisaPGVIDPETgiiYGGG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 157 ALgaegimPGWVGLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGARGLA 236
Cdd:cd24152    77 AL------PYLKGFNLKEELEERCNLPVSIENDAKCAALAELWLGSLKGIKNGAVIVLGTGIGGAIIIDGKLYRGSHFFA 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 237 GEIGHLPLITDGlicrcGNRGCLETVASPVAIARLLSESWGQTVAP-RDLPALIRERNSGALRAVRDAGDAVGRALAALV 315
Cdd:cd24152   151 GEFSYLLTDDDD-----KDLLFFSGLASMFGLVKRYNKAKGLEPLDgEEIFEKYAKGDEAAKKILDEYIRNLAKLIYNIQ 225

                         250
                  ....*....|..
gi 2770181927 316 TLLNPSLVVVGG 327
Cdd:cd24152   226 YILDPEVIVIGG 237
PRK13311 PRK13311
N-acetyl-D-glucosamine kinase; Provisional
 164-318 2.74e-12

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 106271 [Multi-domain]  Cd Length: 256  Bit Score: 66.21  E-value: 2.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 164 MPGWVGLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGRQAGDMVYVRLSAGIGAGIVSNGRLLLGARGLAGEIGHLP 243
Cdd:PRK13311   80 VPSAMGQPLQADLSRLIQREVRIDNDANCFALSEAWDPEFRTYPTVLGLILGTGVGGGLIVNGSIVSGRNHITGEFGHFR 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 244 LITDGL----------ICRCGNRGCLETVASPVAIARLLSESWGQTVAPRDLPALIRERNSGALRAVRDAGDAVGRALAA 313
Cdd:PRK13311  160 LPVDALdilgadiprvPCGCGHRGCIENYISGRGFEWMYSHFYQHTLPATDIIAHYAAGEPKAVAHVERFMDVLAVCLGN 239


                  ....*
gi 2770181927 314 LVTLL 318
Cdd:PRK13311  240 LLTML 244
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 143-327 4.90e-10

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 59.12  E-value: 4.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 143 IGAGIASPVEIGSgALGAEGIMPGWVGLRLTDELRRRTSLPVRVTNDANAGALAERMYGAGR-QAGDMVYVRLSAGIGAG 221
Cdd:cd24058    58 VGVGFPGVVRRGV-VRTAANLDKSWIGFDAAKLLSKRLGRPVRVLNDADAAGLAEMKGGAGKgEKGVVLVLTLGTGIGSA 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927 222 IVSNGRLLLGArglagEIGHLPLitdglicrcgNRGCLETVASpVAIARLLSESWgQTVAPRdlpalirernsgalravr 301
Cdd:cd24058   137 LFVDGHLVPNT-----ELGHLEI----------RGKDAEERAS-LGVRAREDLGW-KRWAKR------------------ 181

                         170       180
                  ....*....|....*....|....*.
gi 2770181927 302 dagdaVGRALAALVTLLNPSLVVVGG 327
Cdd:cd24058   182 -----VNKYLQYLERLFNPDLFIIGG 202
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 9-57 1.33e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 39.49  E-value: 1.33e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2770181927   9 LRVLEALHTSPRSSRPELVRVTGLSRATVSSLIADLITVGLVTEDESPE 57
Cdd:pfam12802   8 FRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPA 56
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
8-55 2.38e-04

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 42.57  E-value: 2.38e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2770181927   8 RLRVLEALHTSPRSsRPELVRVTGLSRATVSSLIADLITVGLVTEDES 55
Cdd:COG4742    18 RKNILLLLAEGPKT-RSELAESLDVSRSTILRQLKELEERGLIERDDG 64
ASKHA_NBD_FGGY_L-RBK cd07781
nucleotide-binding domain (NBD) of ribulokinase (RBK) and similar proteins; RBK (EC 2.7.1.16; ...
 79-145 5.18e-04

nucleotide-binding domain (NBD) of ribulokinase (RBK) and similar proteins; RBK (EC 2.7.1.16; also known as L-ribulokinase) catalyzes the MgATP-dependent phosphorylation of L(or D)-ribulose to produce L(or D)-ribulose 5-phosphate and ADP, which is the second step in arabinose catabolism. It also phosphorylates a variety of other sugar substrates including ribitol and arabitol. Members of this subfamily belong to the FGGY family of carbohydrate kinases, the monomers of which contain two large domains, which are separated by a deep cleft that forms the active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain.


Pssm-ID: 466799 [Multi-domain]  Cd Length: 504  Bit Score: 42.14  E-value: 5.18e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2770181927  79 YAIGADIGHQHVRVILCDL-------FGEVLWEHWV-AKDVDRA---PDETLDLVAVLVGRALQETGVGRERVLGIGA 145
Cdd:cd07781     1 YVIGIDFGTQSVRAGLVDLadgeelaSAVVPYPTGYiPPRPGWAeqnPADYWEALEEAVRGALAEAGVDPEDVVGIGV 78
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
4-53 1.09e-03

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 39.48  E-value: 1.09e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2770181927   4 REVGRlRVLEALHTSPRSSRPELVRVTGLSRATVSSLIADLITVGLVTED 53
Cdd:COG3398    96 RETPR-RILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERE 144
ASKHA_NBD_FGGY_YoaC-like cd07798
nucleotide-binding domain (NBD) of Bacillus subtilis sugar kinase YoaC and similar proteins; ...
 79-145 1.72e-03

nucleotide-binding domain (NBD) of Bacillus subtilis sugar kinase YoaC and similar proteins; The subfamily includes a group of uncharacterized proteins with similarity to Bacillus subtilis sugar kinase YoaC. It is part of the yoaDCB operon and induced by sulfate. Members of this subfamily belong to the FGGY family of carbohydrate kinases, the monomers of which contain two large domains, which are separated by a deep cleft that forms the active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain.


Pssm-ID: 466804 [Multi-domain]  Cd Length: 448  Bit Score: 40.28  E-value: 1.72e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2770181927  79 YAIGADIGHQHVRVILCDLFGEVL------WEHWVAKDVDRA----PDETLDLVAVLVGRALQETGVGRERVLGIGA 145
Cdd:cd07798     1 YYLVIDIGTGGGRCALVDSEGKIVaiayreWEYYTDDDYPDAkefdPEELWEKICEAIREALKKAGISPEDISAVSS 77
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 8-52 4.22e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 35.74  E-value: 4.22e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2770181927   8 RLRVLEALHTSPRSSRpELVRVTGLSRATVSSLIADLITVGLVTE 52
Cdd:cd00090     9 RLRILRLLLEGPLTVS-ELAERLGLSQSTVSRHLKKLEEAGLVES 52
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
8-179 7.29e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 37.60  E-value: 7.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927   8 RLRVLEALHTSPRSSRPELVRVTGLSRATVSSLIADLITVGLVTedespEEQEPRRTGRPAQSLSLVPSAgyaiGADIGH 87
Cdd:COG2345    15 RRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVE-----RETERRGRGRPAKLYRLTEAG----RARFPR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770181927  88 QHvrvilcDLFGEVLWEHWvakdVDRAPDETLDLVAVLVGRALQETgvgRERVLGIGAGIASPVEIGSGALGAEGIMPGW 167
Cdd:COG2345    86 AY------DDLAVALLDAL----RELLGEDAVERLARARGRRLAAR---YRPALAGAGSLEERLEALAELLSEEGYMAEV 152

                         170
                  ....*....|..
gi 2770181927 168 VGLRLTDELRRR 179
Cdd:COG2345   153 EEEDDGFQLCEH 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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