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Conserved domains on  [gi|2767011454|ref|WP_364017770|]
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ArsR family transcriptional regulator [Amycolatopsis mediterranei]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
177-242 6.53e-10

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 54.51  E-value: 6.53e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2767011454 177 SDALAVLVGATRAAVLRALAQ-PSTTSGIAGHVGISVSSASEHTTALRNAGLVTSHRLGQAVHHHLT 242
Cdd:COG0640    11 AELFKALADPTRLRILRLLAEgELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLA 77
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
177-242 6.53e-10

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 54.51  E-value: 6.53e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2767011454 177 SDALAVLVGATRAAVLRALAQ-PSTTSGIAGHVGISVSSASEHTTALRNAGLVTSHRLGQAVHHHLT 242
Cdd:COG0640    11 AELFKALADPTRLRILRLLAEgELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLA 77
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 177-241 4.59e-08

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 49.00  E-value: 4.59e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2767011454 177 SDALAVLVGATRAAVLRALAQ-PSTTSGIAGHVGISVSSASEHTTALRNAGLVTSHRLGQAVHHHL 241
Cdd:NF033788    2 AELFKALADPTRLRILELLAEgELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRL 67
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 187-243 3.10e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 46.91  E-value: 3.10e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2767011454 187 TRAAVLRALAQ-PSTTSGIAGHVGISVSSASEHTTALRNAGLVTSHRLGQAVHHHLTH 243
Cdd:cd00090     8 TRLRILRLLLEgPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTD 65
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
191-243 1.44e-06

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 44.51  E-value: 1.44e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2767011454  191 VLRALAQPS-TTSGIAGHVGISVSSASEHTTALRNAGLVTSHRLGQAVHHHLTH 243
Cdd:smart00418   2 ILKLLAEGElCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTD 55
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 187-228 2.78e-06

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 43.20  E-value: 2.78e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2767011454 187 TRAAVLRALA-QPSTTSGIAGHVGISVSSASEHTTALRNAGLV 228
Cdd:pfam01022   3 TRLKILKLLAeGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
177-242 6.53e-10

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 54.51  E-value: 6.53e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2767011454 177 SDALAVLVGATRAAVLRALAQ-PSTTSGIAGHVGISVSSASEHTTALRNAGLVTSHRLGQAVHHHLT 242
Cdd:COG0640    11 AELFKALADPTRLRILRLLAEgELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLA 77
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 177-241 4.59e-08

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 49.00  E-value: 4.59e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2767011454 177 SDALAVLVGATRAAVLRALAQ-PSTTSGIAGHVGISVSSASEHTTALRNAGLVTSHRLGQAVHHHL 241
Cdd:NF033788    2 AELFKALADPTRLRILELLAEgELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRL 67
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 187-243 3.10e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 46.91  E-value: 3.10e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2767011454 187 TRAAVLRALAQ-PSTTSGIAGHVGISVSSASEHTTALRNAGLVTSHRLGQAVHHHLTH 243
Cdd:cd00090     8 TRLRILRLLLEgPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTD 65
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
191-243 1.44e-06

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 44.51  E-value: 1.44e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2767011454  191 VLRALAQPS-TTSGIAGHVGISVSSASEHTTALRNAGLVTSHRLGQAVHHHLTH 243
Cdd:smart00418   2 ILKLLAEGElCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTD 55
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
178-232 1.68e-06

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 45.80  E-value: 1.68e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2767011454 178 DALAVLVGATRAAVLRALAQ-PSTTSGIAGHVGISVSSASEHTTALRNAGLVTSHR 232
Cdd:COG1777     9 RLLDALGNPTRRRILALLSEePAYVSELARELGVSRQAVYKHLRKLEEAGLVESYR 64
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 187-228 2.78e-06

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 43.20  E-value: 2.78e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2767011454 187 TRAAVLRALA-QPSTTSGIAGHVGISVSSASEHTTALRNAGLV 228
Cdd:pfam01022   3 TRLKILKLLAeGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
157-243 3.70e-05

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 42.94  E-value: 3.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2767011454 157 YVLIYPARTNHGAIESTtgtsdALAVLVGATRAAVLRALAQ--PSTTSGIAGHVGISVSSASEHTTALRNAGLVTSHRLG 234
Cdd:COG3398    73 RTRYFPNSGTYSEEEKK-----ILAYLRRETPRRILLYLLEnpGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDG 147


                  ....*....
gi 2767011454 235 QAVHHHLTH 243
Cdd:COG3398   148 RNVRYYLNP 156
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 178-235 9.35e-05

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 39.44  E-value: 9.35e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2767011454 178 DALAVLVGATRAAVLRALA--QPSTTSGIAGHVGISVSSASEHTTALRNAGLVTSHRLGQ 235
Cdd:pfam12840   2 DVAEALADPTRLRILRALVgdEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
176-232 6.21e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 39.91  E-value: 6.21e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2767011454 176 TSDALAVLVGATRAAVLRALAQ--PSTTSGIAGHVGISVSSASEHTTALRNAGLVTSHR 232
Cdd:COG2345     3 DTPALAALADPTRRRILELLKRagPVTAAELAEALGLTPNAVRRHLDALEEEGLVERET 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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