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Conserved domains on  [gi|2767011338|ref|WP_364017666|]
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MarR family transcriptional regulator [Amycolatopsis mediterranei]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
4-143 5.89e-21

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 82.71  E-value: 5.89e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2767011338   4 SRQHDAAWRGFLRSSALLLRVLDAELRAaHGMSHRTYDALVQLSEAParRLHMKDLADALVHSRSGLTRLVDGLESAGYA 83
Cdd:COG1846     6 DPAEERLGLLLRRLARALRRALDRALAE-LGLTPAQFRVLAALAEAG--GLTQSELAERLGLTKSTVSRLLDRLEEKGLV 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2767011338  84 RREPDPVNRRSTLVVLTDEGLAALEAAWPTHVRGVQRHFADrMTGEQARMLAEVFRGISA 143
Cdd:COG1846    83 EREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAG-LSEEELEALLRLLRRLAE 141
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
4-143 5.89e-21

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 82.71  E-value: 5.89e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2767011338   4 SRQHDAAWRGFLRSSALLLRVLDAELRAaHGMSHRTYDALVQLSEAParRLHMKDLADALVHSRSGLTRLVDGLESAGYA 83
Cdd:COG1846     6 DPAEERLGLLLRRLARALRRALDRALAE-LGLTPAQFRVLAALAEAG--GLTQSELAERLGLTKSTVSRLLDRLEEKGLV 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2767011338  84 RREPDPVNRRSTLVVLTDEGLAALEAAWPTHVRGVQRHFADrMTGEQARMLAEVFRGISA 143
Cdd:COG1846    83 EREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAG-LSEEELEALLRLLRRLAE 141
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
31-144 1.89e-16

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 69.93  E-value: 1.89e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2767011338   31 AAHGMSHRTYDALVQLSEAParRLHMKDLADALVHSRSGLTRLVDGLESAGYARREPDPVNRRSTLVVLTDEGlaaleaa 110
Cdd:smart00347   4 KPLGLTPTQFLVLRILYEEG--PLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEG------- 74

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2767011338  111 wpthvrgvqRHFADRMTGEQARMLAEVFRGISAE 144
Cdd:smart00347  75 ---------RELIEQLLEARSETLAELLAGLTAE 99
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 33-94 1.00e-07

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 46.04  E-value: 1.00e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2767011338  33 HGMSHRTYDALVQLSEAPArrLHMKDLADALVHSRSGLTRLVDGLESAGYARREPDPVNRRS 94
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPG--LTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
70-108 4.32e-04

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 38.34  E-value: 4.32e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2767011338  70 LTRLVDGLESAGYARREPDPVNRRSTLVVLTDEGLAALE 108
Cdd:PRK11512   71 LTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTSGAAICE 109
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
4-143 5.89e-21

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 82.71  E-value: 5.89e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2767011338   4 SRQHDAAWRGFLRSSALLLRVLDAELRAaHGMSHRTYDALVQLSEAParRLHMKDLADALVHSRSGLTRLVDGLESAGYA 83
Cdd:COG1846     6 DPAEERLGLLLRRLARALRRALDRALAE-LGLTPAQFRVLAALAEAG--GLTQSELAERLGLTKSTVSRLLDRLEEKGLV 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2767011338  84 RREPDPVNRRSTLVVLTDEGLAALEAAWPTHVRGVQRHFADrMTGEQARMLAEVFRGISA 143
Cdd:COG1846    83 EREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAG-LSEEELEALLRLLRRLAE 141
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
31-144 1.89e-16

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 69.93  E-value: 1.89e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2767011338   31 AAHGMSHRTYDALVQLSEAParRLHMKDLADALVHSRSGLTRLVDGLESAGYARREPDPVNRRSTLVVLTDEGlaaleaa 110
Cdd:smart00347   4 KPLGLTPTQFLVLRILYEEG--PLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEG------- 74

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2767011338  111 wpthvrgvqRHFADRMTGEQARMLAEVFRGISAE 144
Cdd:smart00347  75 ---------RELIEQLLEARSETLAELLAGLTAE 99
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 33-94 1.00e-07

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 46.04  E-value: 1.00e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2767011338  33 HGMSHRTYDALVQLSEAPArrLHMKDLADALVHSRSGLTRLVDGLESAGYARREPDPVNRRS 94
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPG--LTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 40-95 9.85e-06

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 40.61  E-value: 9.85e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2767011338  40 YDALVQLSEAPArrLHMKDLADALVHSRSGLTRLVDGLESAGYARREPDPVNRRST 95
Cdd:pfam01047   6 FHILRILYEHGP--LTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
70-108 4.32e-04

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 38.34  E-value: 4.32e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2767011338  70 LTRLVDGLESAGYARREPDPVNRRSTLVVLTDEGLAALE 108
Cdd:PRK11512   71 LTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTSGAAICE 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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